Peregrine Ventures

Lutris Pharma is a biopharmaceutical company based in Tel Aviv-Yafo, Israel, founded in 2015. The company focuses on developing therapeutic drugs aimed at enhancing the effectiveness of anti-cancer therapies. Its lead product, LUT014, is a proprietary small molecule B-Raf inhibitor designed to facilitate the administration of epidermal growth factor receptor (EGFR) inhibitors. This innovative approach helps mitigate the common cutaneous side effects associated with EGFR treatments, thereby improving the overall quality of life for patients undergoing cancer therapy.

BioProtect Ltd. is an international medical device startup focused on developing and commercializing biodegradable balloon spacers designed to protect normal tissue during cancer radiation therapy. The company's flagship product, the ProSpace balloon spacer, has demonstrated superior efficacy and safety in safeguarding the rectum during radiation treatment for prostate cancer. This innovative technology significantly reduces the risk of serious and chronic side effects associated with radiation, while enhancing tumor control. Founded in 2004 and headquartered in Israel, BioProtect also operates subsidiaries in Germany and the United States, aiming to address unmet clinical needs in the growing radiotherapy spacers market with its platform of biodegradable implantable balloons.

Althea Medical, established in 2020 in Tel Aviv, Israel, focuses on developing catheter devices for the treatment of patients suffering from pulmonary embolism (PE), including both massive and sub-massive cases. The company's innovative catheter-based solution combines the effectiveness of large bore thrombectomy with a user-friendly delivery mechanism that reduces patient risks. This mechanical clot removal system is designed to efficiently capture and eliminate thrombus, allowing physicians to swiftly access blocked areas and alleviate clot burden, thereby enhancing hemodynamic stability in affected patients.

Nectin Therapeutics Ltd., founded in 2017 and based in Jerusalem, Israel, specializes in the development of monoclonal antibodies targeting members of the Nectin family of receptors and ligands. These antibodies are designed to address immune checkpoint mechanisms that play a crucial role in cancer immunotherapy. By focusing on both solid and hematological malignancies, Nectin Therapeutics aims to create therapies that can overcome the inhibitory pathways utilized by tumors, thereby enhancing the ability of immune cells to eradicate cancer cells. The company's innovative approach seeks to improve patient outcomes in cancer treatment.

Cordio Medical LTD. is a company based in Or Yehuda, Israel, founded in 2013, that specializes in developing a mobile application aimed at monitoring patients with congestive heart failure. The application utilizes advanced speech processing technology to analyze a patient's voice, allowing for near real-time monitoring and early detection of health deterioration. By transcribing patients' speech, the platform assists healthcare providers in identifying potential issues, enabling them to intervene before conditions worsen and prevent unnecessary hospitalizations. This innovative approach emphasizes patient well-being and aims to facilitate care management while allowing patients to remain at home.

BrainQ is a company founded in 2016 and headquartered in Jerusalem, Israel, that focuses on developing precision neurology therapies for individuals with neuro disorders. The company operates a neuro recovery platform that employs a brain-computer interface (BCI) approach to target damaged neuronal networks. By integrating machine learning algorithms with neuroscience, BrainQ extracts biological insights that inform the creation of tailored therapies. These innovations aim to facilitate neuro recovery and enhance the quality of life for patients, enabling them to live more independent and fulfilling lives.

Aleph Farms Limited, based in Ashdod, Israel, is a food technology company focused on sustainable animal product innovation through cellular agriculture. Founded in 2017, Aleph Farms has pioneered the development of lab-cultured meat, notably unveiling the world’s first cultivated thin-cut steak in 2018 and the first cultivated ribeye steak in 2021. The company utilizes proprietary three-dimensional bioprinting technology to grow animal products directly from non-genetically modified cells, thereby eliminating the need for animal slaughter. Under its product brand, Aleph Cuts, Aleph Farms is set to launch the Petit Steak, which is produced from premium Angus cow cells. The company has been recognized for its commitment to climate leadership and sustainability, receiving accolades from the World Economic Forum and the United Nations for its net zero commitment made in 2020.

Aleph Farms Limited, based in Ashdod, Israel, is a food technology company focused on sustainable animal product innovation through cellular agriculture. Founded in 2017, Aleph Farms has pioneered the development of lab-cultured meat, notably unveiling the world’s first cultivated thin-cut steak in 2018 and the first cultivated ribeye steak in 2021. The company utilizes proprietary three-dimensional bioprinting technology to grow animal products directly from non-genetically modified cells, thereby eliminating the need for animal slaughter. Under its product brand, Aleph Cuts, Aleph Farms is set to launch the Petit Steak, which is produced from premium Angus cow cells. The company has been recognized for its commitment to climate leadership and sustainability, receiving accolades from the World Economic Forum and the United Nations for its net zero commitment made in 2020.

BioProtect Ltd. is an international medical device startup focused on developing and commercializing biodegradable balloon spacers designed to protect normal tissue during cancer radiation therapy. The company's flagship product, the ProSpace balloon spacer, has demonstrated superior efficacy and safety in safeguarding the rectum during radiation treatment for prostate cancer. This innovative technology significantly reduces the risk of serious and chronic side effects associated with radiation, while enhancing tumor control. Founded in 2004 and headquartered in Israel, BioProtect also operates subsidiaries in Germany and the United States, aiming to address unmet clinical needs in the growing radiotherapy spacers market with its platform of biodegradable implantable balloons.

Hairstetics Ltd. is an innovative medical device company based in Omer, Israel, founded in 2010. The company specializes in the development, manufacturing, and marketing of advanced hair restoration devices. Hairstetics offers a range of solutions, including surgical hair transplantation and non-surgical methods, alongside customizable hair implantation services that allow for various colors, styles, and lengths. Their products are designed to simplify the hair implantation procedure, reduce recovery time, and deliver enhanced aesthetic results at a more affordable cost compared to traditional techniques. Through these offerings, Hairstetics aims to provide effective solutions for individuals experiencing hair loss.

SinuSafe Medical, founded in 2014 and based in Tel Aviv, Israel, focuses on developing a nano-debrider device aimed at treating sinus-related issues without the need for surgical intervention. This innovative device allows for sinus irrigation and aspiration by implanting bone between the lining and the maxillary sinus, providing a non-invasive solution for patients suffering from chronic sinusitis. By enabling sinus lavage in a physician's office, SinuSafe Medical offers ear, nose, and throat (ENT) specialists a means to deliver immediate relief to their patients, thereby improving their quality of life.

Restore Medical is a medical device company focused on treating congestive heart failure, specifically targeting patients with left ventricle failure. Founded in 2016 and based in Or Yehuda, Israel, the company offers ContraBand, a catheter-delivered implant designed for placement in the pulmonary arteries. This innovative device aims to enhance left ventricle ejection fraction, decrease mitral regurgitation, and restore favorable ventricular geometry. By improving patient outcomes, Restore Medical's solutions contribute to a better quality of life and aim to reduce the rates of hospital readmission among affected individuals.

Raziel Health, established in 2012 and headquartered in Rehovot, Israel, is a pharmaceutical company with a dual focus. Firstly, it develops injectable treatments, notably RZL-012, a novel synthetic small molecule designed to reduce fat tissue by causing fat cell death at the injection site. This drug is currently in clinical trials for various fat tissue indications and aesthetics. Secondly, Raziel Health offers a patient monitoring platform that uses artificial intelligence and machine learning to support remote patient care, enabling healthcare providers to improve patient outcomes across a wide range of conditions. The company's mission is to provide world-class, affordable healthcare in the comfort of patients' homes.

Raziel Health, established in 2012 and headquartered in Rehovot, Israel, is a pharmaceutical company with a dual focus. Firstly, it develops injectable treatments, notably RZL-012, a novel synthetic small molecule designed to reduce fat tissue by causing fat cell death at the injection site. This drug is currently in clinical trials for various fat tissue indications and aesthetics. Secondly, Raziel Health offers a patient monitoring platform that uses artificial intelligence and machine learning to support remote patient care, enabling healthcare providers to improve patient outcomes across a wide range of conditions. The company's mission is to provide world-class, affordable healthcare in the comfort of patients' homes.

Aleph Farms Limited, based in Ashdod, Israel, is a food technology company focused on sustainable animal product innovation through cellular agriculture. Founded in 2017, Aleph Farms has pioneered the development of lab-cultured meat, notably unveiling the world’s first cultivated thin-cut steak in 2018 and the first cultivated ribeye steak in 2021. The company utilizes proprietary three-dimensional bioprinting technology to grow animal products directly from non-genetically modified cells, thereby eliminating the need for animal slaughter. Under its product brand, Aleph Cuts, Aleph Farms is set to launch the Petit Steak, which is produced from premium Angus cow cells. The company has been recognized for its commitment to climate leadership and sustainability, receiving accolades from the World Economic Forum and the United Nations for its net zero commitment made in 2020.

Magnisity is a technology company founded in 2018 in Or Yehuda, Israel, by Benny Greenburg and Ron Barak. It specializes in developing innovative solutions for minimally invasive surgeries through a unique platform that integrates hardware design, software development, precise mechanics, and engineering. By leveraging advanced algorithms, Magnisity aims to enhance the capabilities of medical devices, enabling surgeons to address complex challenges in endoluminal interventions effectively. The company's focus on creating tools for both surgeons and patients positions it as a key player in the evolution of minimally invasive medicine.

Hairstetics Ltd. is an innovative medical device company based in Omer, Israel, founded in 2010. The company specializes in the development, manufacturing, and marketing of advanced hair restoration devices. Hairstetics offers a range of solutions, including surgical hair transplantation and non-surgical methods, alongside customizable hair implantation services that allow for various colors, styles, and lengths. Their products are designed to simplify the hair implantation procedure, reduce recovery time, and deliver enhanced aesthetic results at a more affordable cost compared to traditional techniques. Through these offerings, Hairstetics aims to provide effective solutions for individuals experiencing hair loss.

CliClap LTD is a content marketing utility based in Kfar Saba, Israel, founded in 2016. The company offers an AI-powered platform designed to enhance audience engagement and brand visibility by tracking and optimizing shared content. Its solution supports businesses in generating leads and increasing traffic through effective content marketing strategies. By guiding visitors through personalized content journeys, CliClap helps nurture qualified leads without requiring extensive management. The platform integrates seamlessly with existing marketing automation, CRM, and social media management tools, allowing marketing teams to operate more efficiently and significantly boost conversion rates. Overall, CliClap aims to drive business goals by providing actionable insights and enhancing user interaction with content.

CliClap LTD is a content marketing utility based in Kfar Saba, Israel, founded in 2016. The company offers an AI-powered platform designed to enhance audience engagement and brand visibility by tracking and optimizing shared content. Its solution supports businesses in generating leads and increasing traffic through effective content marketing strategies. By guiding visitors through personalized content journeys, CliClap helps nurture qualified leads without requiring extensive management. The platform integrates seamlessly with existing marketing automation, CRM, and social media management tools, allowing marketing teams to operate more efficiently and significantly boost conversion rates. Overall, CliClap aims to drive business goals by providing actionable insights and enhancing user interaction with content.

Cordio Medical LTD. is a company based in Or Yehuda, Israel, founded in 2013, that specializes in developing a mobile application aimed at monitoring patients with congestive heart failure. The application utilizes advanced speech processing technology to analyze a patient's voice, allowing for near real-time monitoring and early detection of health deterioration. By transcribing patients' speech, the platform assists healthcare providers in identifying potential issues, enabling them to intervene before conditions worsen and prevent unnecessary hospitalizations. This innovative approach emphasizes patient well-being and aims to facilitate care management while allowing patients to remain at home.

Cordio Medical LTD. is a company based in Or Yehuda, Israel, founded in 2013, that specializes in developing a mobile application aimed at monitoring patients with congestive heart failure. The application utilizes advanced speech processing technology to analyze a patient's voice, allowing for near real-time monitoring and early detection of health deterioration. By transcribing patients' speech, the platform assists healthcare providers in identifying potential issues, enabling them to intervene before conditions worsen and prevent unnecessary hospitalizations. This innovative approach emphasizes patient well-being and aims to facilitate care management while allowing patients to remain at home.

NeuroApplied Ltd. is a marketing research company based in Hadera, Israel, founded in June 2016. The firm specializes in customer-focused marketing by exploring the collective subconscious of consumers. Utilizing machine-learning analytics and neural-network computing, NeuroApplied's platform incorporates online picture games to collect data that reflects customers' associative subconscious responses. This SaaS-based platform features an intuitive dashboard that presents insights in a visually engaging and nonintrusive manner. The services offered include brand equity assessment, tracking of brand properties, crisis management, and decision support, all designed to help brand managers understand and quantify consumer perceptions effectively.

Eximo Medical Ltd. is an Israeli company specializing in hybrid catheter technology aimed at improving tissue resection in vascular and gastrointestinal endoluminal applications. Founded in 2012 and based in Modi'in-Maccabim-Re'ut, the company has developed the CatHI™, a proprietary single-use hybrid catheter that integrates optical fibers for delivering short laser pulses with a blunt mechanical knife. This innovative design enhances the safety and effectiveness of procedures, particularly in lead extraction and the treatment of peripheral artery disease, by minimizing the risk of vessel perforation. As of October 2019, Eximo Medical operates as a subsidiary of AngioDynamics, Inc.

SinuSafe Medical, founded in 2014 and based in Tel Aviv, Israel, focuses on developing a nano-debrider device aimed at treating sinus-related issues without the need for surgical intervention. This innovative device allows for sinus irrigation and aspiration by implanting bone between the lining and the maxillary sinus, providing a non-invasive solution for patients suffering from chronic sinusitis. By enabling sinus lavage in a physician's office, SinuSafe Medical offers ear, nose, and throat (ENT) specialists a means to deliver immediate relief to their patients, thereby improving their quality of life.

Cordio Medical LTD. is a company based in Or Yehuda, Israel, founded in 2013, that specializes in developing a mobile application aimed at monitoring patients with congestive heart failure. The application utilizes advanced speech processing technology to analyze a patient's voice, allowing for near real-time monitoring and early detection of health deterioration. By transcribing patients' speech, the platform assists healthcare providers in identifying potential issues, enabling them to intervene before conditions worsen and prevent unnecessary hospitalizations. This innovative approach emphasizes patient well-being and aims to facilitate care management while allowing patients to remain at home.

ShapeDo Ltd. is a software company based in Modi'in-Maccabim-Re'ut, Israel, founded in 2014. It specializes in developing solutions to manage the implications of plan changes in construction projects. The company's cloud-based platform facilitates end-to-end management of these changes by organizing blueprints, comparing versions, and ensuring that all modifications are reflected in contracts, budgets, and agreements. ShapeDo's software aids in creating court-ready pricing reports, requests for information, and claims. The company has been involved in significant infrastructure projects, including airports, underground trains, hospitals, and data centers, and its solutions are also applicable to smaller commercial and residential projects.

Jobrain Ltd. is a Herzliya, Israel-based company that offers a cloud-based hiring software designed to streamline the recruitment process for HR professionals. The platform allows candidates to easily apply for jobs using mobile devices, while HR teams can quickly identify and hire the best talent. Jobrain provides an open marketplace that includes various talent acquisition services such as job post distribution, remote interviews, one-way video interviews, and candidate assessments. Additionally, it features a job search application that connects users to a network of recruiters, utilizing machine learning to match candidates with over 100,000 job opportunities worldwide, primarily in software development and small startups. By leveraging data science, Jobrain simplifies the hiring process, enabling clients to focus on essential tasks rather than administrative burdens.

Zuznow is a mobile application development company that specializes in adapting complex websites for optimal use on smartphones. Founded in 2009 and based in Israel, Zuznow's platform automatically analyzes the visual structure of desktop websites and transforms them for mobile devices. This capability allows businesses to implement effective mobile strategies for various applications, including B2B, B2C, and B2E. The platform streamlines the development process, enabling organizations to create secure mobile applications while significantly reducing time to market and lowering costs associated with setup and maintenance. Zuznow's clientele includes notable companies such as VentureBeat, HOOP, Newsgeek, and Baker Tilly.

Marketyze is a technology company specializing in semantic site search and online price comparison solutions, primarily serving the retail industry. Founded in December 2011 by Onn Manelson and Nave Ronen, the company is based in Israel. Marketyze's pricing intelligence software collects and examines pricing, market, and internal data to assess the impact of pricing events on sales performance. This analysis enables retailers to refine their pricing strategies, ultimately aiming to enhance both sales and profitability. Additionally, Marketyze provides a cloud-based platform that monitors and evaluates product prices among competitors, delivering essential pricing data and analytics to online retailers.

ArTack Medical is a privately held medical device company based in Haifa, Israel, founded in 2013. The company specializes in developing innovative tools for the invasive surgery market, particularly focusing on hernia repair. ArTack Medical's flagship product is an articulated hernia mesh fixation device designed to facilitate both laparoscopic and open surgical procedures. This device is compatible with any currently available mesh and allows surgeons to maintain their standard techniques without modification. The company’s patented drive platform enables the delivery of torque through a 5mm shaft, enhancing the effectiveness and ease of surgical interventions.

CartiHeal is a medical device company based in Kfar Sava, Israel, specializing in cartilage and bone regeneration. Founded in 2009, the company has developed the Agili-C implant, a cell-free and off-the-shelf solution designed to address focal articular cartilage and osteochondral defects. This innovative implant promotes the regeneration of hyaline cartilage and the underlying subchondral bone without the need for cells or growth factors, making it a significant advancement in the treatment of cartilage injuries. Given the limited natural healing capacity of hyaline cartilage, CartiHeal's technology offers a promising option for patients suffering from cartilage damage, which can lead to severe pain and disability if untreated. The Agili-C implant can be inserted using arthroscopic or minimally invasive techniques, facilitating faster rehabilitation and enhanced recovery outcomes for patients.

Eximo Medical Ltd. is an Israeli company specializing in hybrid catheter technology aimed at improving tissue resection in vascular and gastrointestinal endoluminal applications. Founded in 2012 and based in Modi'in-Maccabim-Re'ut, the company has developed the CatHI™, a proprietary single-use hybrid catheter that integrates optical fibers for delivering short laser pulses with a blunt mechanical knife. This innovative design enhances the safety and effectiveness of procedures, particularly in lead extraction and the treatment of peripheral artery disease, by minimizing the risk of vessel perforation. As of October 2019, Eximo Medical operates as a subsidiary of AngioDynamics, Inc.

Valire is a software solution company based in HaMerkaz, Israel, specializing in artificial intelligence applications for fraud detection and risk management. Founded in 2009, Valire develops tools that assess fraud risk, validate business processes, and create tailored algorithms to help organizations secure their revenue. By integrating business rules with symbolic machine learning, Valire's software effectively identifies fraudulent behavior while minimizing false positives and ensuring cost-effective implementation. This approach allows businesses to reduce operational risks and enhance performance, ultimately supporting their growth opportunities.

CartiHeal is a medical device company based in Kfar Sava, Israel, specializing in cartilage and bone regeneration. Founded in 2009, the company has developed the Agili-C implant, a cell-free and off-the-shelf solution designed to address focal articular cartilage and osteochondral defects. This innovative implant promotes the regeneration of hyaline cartilage and the underlying subchondral bone without the need for cells or growth factors, making it a significant advancement in the treatment of cartilage injuries. Given the limited natural healing capacity of hyaline cartilage, CartiHeal's technology offers a promising option for patients suffering from cartilage damage, which can lead to severe pain and disability if untreated. The Agili-C implant can be inserted using arthroscopic or minimally invasive techniques, facilitating faster rehabilitation and enhanced recovery outcomes for patients.

Valtech Cardio Ltd. is a medical device company based in Or Yehuda, Israel, specializing in the development and manufacturing of cardiovascular devices aimed at treating mitral regurgitation and facilitating tricuspid valve repair and replacement. The company focuses on minimally invasive transcatheter heart valve technologies, allowing patients to avoid open-heart surgery. Its key products include the Cardioband System, which performs mitral valve reconstruction via transfemoral direct annuloplasty, and the Cardiovalve system, a transfemoral transseptal replacement option for the mitral valve. Additionally, Valtech offers the Cardinal adjustable annuloplasty ring, which allows surgeons to optimize the ring size during surgery. The company's pipeline includes innovative products such as Cardioband Tricuspid, designed for mitral regurgitation, and V-Chordal, an adjustable implanted chord for repairing valve prolapse. Founded in 2006, Valtech Cardio operates as a subsidiary of Zeppelin Zox Ltd. since January 2017.

Kailight Photonics develops optical modules for the telecommunications industry. It offers tunable optical signal regenerator, an optical component that operates with regenerators, optical switches, add/drop multiplexers, and cross-connects. The company's optical transmission, signal regeneration, and wavelength conversion technology provides optical-networking solutions for systems vendors. It provides its products to long-haul network market segments. The company, formerly known as Chilight Technologies, was founded in 2000 and is headquartered in Rehovot, Israel with an additional office in Dallas, Texas. As of May 15, 2007, Kailight Photonics, Inc. operates as a subsidiary of Optium Corporation.