Peregrine Ventures

Lutris Pharma is a biopharmaceutical company based in Tel Aviv-Yafo, Israel, focused on developing innovative therapies to enhance the effectiveness of anti-cancer treatments. Established in 2015, the company has created a proprietary small molecule drug known as LUT014, which acts as a topical B-Raf inhibitor. This drug facilitates the use of epidermal growth factor receptor (EGFR) inhibitors while minimizing the common cutaneous side effects typically associated with such treatments. By addressing these side effects, Lutris Pharma aims to improve both the efficacy of anti-cancer therapies and the overall quality of life for patients undergoing treatment with EGFR inhibitors.

BioProtect Ltd. is an international medical device startup founded in 2004 and headquartered in Israel, with subsidiaries in Germany and the United States. The company specializes in the development and commercialization of biodegradable balloon spacers designed to protect normal tissue during radiation therapy for cancer. Its flagship product, the ProSpace balloon spacer, has received CE marking and demonstrates superior efficacy and safety in safeguarding the rectum during prostate cancer radiation therapy. By creating a temporary separation between the rectum and targeted tissues, BioProtect's technology significantly reduces the risk of serious and chronic side effects associated with radiation treatment while enhancing tumor control. Additionally, the company's platform of biodegradable implantable balloons addresses a variety of unmet clinical needs in the growing radiotherapy spacers market.

Althea Medical is a medical device company based in Tel Aviv, Israel, founded in 2020. It focuses on developing innovative catheter devices specifically designed for the treatment of patients suffering from pulmonary embolism (PE), including both massive and sub-massive cases. The company's technology combines the effectiveness of large bore thrombectomy with a user-friendly delivery method that reduces patient risks. Their mechanical clot removal system is engineered to capture and eliminate thrombus bulk efficiently, allowing physicians to navigate quickly to obstructed areas and restore hemodynamic stability in affected patients.

Nectin Therapeutics Ltd. is a biotechnology company founded in 2017 and based in Jerusalem, Israel. The company specializes in the development of novel monoclonal antibodies that target members of the Nectin family of receptors and ligands, which play significant roles in immune checkpoint mechanisms relevant to cancer immunotherapy. Nectin Therapeutics focuses on creating therapies for both solid and hematological malignancies by designing antibodies that can bypass the inhibitory pathways used by tumors, thereby enhancing the ability of immune cells to effectively eliminate cancer cells. Through its innovative approach, the company aims to improve patient outcomes in the fight against cancer.

Cordio Medical LTD. is an innovative healthcare company based in Or Yehuda, Israel, founded in 2013. It specializes in developing a mobile application that leverages advanced speech processing technology to monitor patients with congestive heart failure. The platform enables near real-time monitoring and early detection of health deterioration through the analysis of patients' voice recordings. By transcribing patients' free speech into actionable insights, Cordio Medical assists healthcare providers in identifying and mitigating worsening conditions, ultimately aiming to prevent unnecessary hospitalizations and promote patient well-being. The company's approach integrates machine learning capabilities tailored to individual patients, enhancing the effectiveness of remote health monitoring and support.

BrainQ is a company that specializes in developing precision neurology therapies aimed at treating impaired brain functions. Founded in 2016 and headquartered in Jerusalem, Israel, BrainQ utilizes a brain-computer interface (BCI)-based approach to target damaged neuronal networks and promote neuro recovery. By integrating machine learning algorithms with neuroscience, the company extracts biological insights that inform the creation of tailored therapies. This innovative approach aims to empower individuals with neurological disorders, helping them achieve greater independence and improved quality of life.

Aleph Farms Limited is an innovative food technology company based in Ashdod, Israel, specializing in cellular agriculture to produce clean meat. Founded in 2017, Aleph Farms focuses on sustainable food production by developing methods to grow animal products directly from non-genetically modified animal cells, utilizing proprietary three-dimensional bioprinting technologies. The company made significant strides in the industry by unveiling the world's first cultivated thin-cut steak in 2018, followed by the first cultivated ribeye steak in 2021 and cultivated collagen in 2022. Under its product brand Aleph Cuts, its inaugural offering, the Petit Steak, is crafted from non-modified cells sourced from a premium Angus cow, allowing production without animal slaughter. Aleph Farms has garnered recognition for its commitment to climate leadership, including a net zero pledge made in 2020, earning accolades from prominent organizations like the World Economic Forum and the United Nations.

Aleph Farms Limited is an innovative food technology company based in Ashdod, Israel, specializing in cellular agriculture to produce clean meat. Founded in 2017, Aleph Farms focuses on sustainable food production by developing methods to grow animal products directly from non-genetically modified animal cells, utilizing proprietary three-dimensional bioprinting technologies. The company made significant strides in the industry by unveiling the world's first cultivated thin-cut steak in 2018, followed by the first cultivated ribeye steak in 2021 and cultivated collagen in 2022. Under its product brand Aleph Cuts, its inaugural offering, the Petit Steak, is crafted from non-modified cells sourced from a premium Angus cow, allowing production without animal slaughter. Aleph Farms has garnered recognition for its commitment to climate leadership, including a net zero pledge made in 2020, earning accolades from prominent organizations like the World Economic Forum and the United Nations.

BioProtect Ltd. is an international medical device startup founded in 2004 and headquartered in Israel, with subsidiaries in Germany and the United States. The company specializes in the development and commercialization of biodegradable balloon spacers designed to protect normal tissue during radiation therapy for cancer. Its flagship product, the ProSpace balloon spacer, has received CE marking and demonstrates superior efficacy and safety in safeguarding the rectum during prostate cancer radiation therapy. By creating a temporary separation between the rectum and targeted tissues, BioProtect's technology significantly reduces the risk of serious and chronic side effects associated with radiation treatment while enhancing tumor control. Additionally, the company's platform of biodegradable implantable balloons addresses a variety of unmet clinical needs in the growing radiotherapy spacers market.

Hairstetics Ltd. is a medical device company based in Omer, Israel, specializing in the development, manufacturing, and marketing of advanced hair restoration devices. Established in 2010, the company focuses on providing innovative solutions for hair loss, including both surgical hair transplantation and non-surgical options. Hairstetics offers a diverse range of hair implantations, allowing customers to choose from various colors, styles, and lengths. Their products are designed to simplify the implantation process, reduce recovery times, and deliver enhanced aesthetic outcomes at a more affordable price compared to traditional methods, thus catering to individuals seeking effective treatments for hair loss.

SinuSafe Medical is an innovative medical device company headquartered in Tel Aviv, Israel, founded in 2014. The company specializes in developing a nano-debrider device designed to address sinus-related issues without the need for surgical intervention. This device enables the irrigation and aspiration of the sinuses, providing a non-invasive solution for patients suffering from chronic sinusitis. By allowing sinus lavage to be performed in a physician's office, SinuSafe Medical aims to deliver immediate relief to ear, nose, and throat (ENT) patients, enhancing their overall treatment experience.

Restore Medical is a medical device company based in Or Yehuda, Israel, established in 2016. The company specializes in providing innovative treatment solutions for patients suffering from congestive heart failure. Its flagship product, ContraBand, is a catheter-delivered implant designed specifically for patients with left ventricle failure who have preserved right ventricle function. This device aims to enhance left ventricle ejection fraction, minimize mitral regurgitation, and restore optimal ventricular geometry. By addressing these critical issues, Restore Medical's technology seeks to significantly improve patient quality of life and decrease rates of hospital readmission.

Raziel Health, established in 2012 and headquartered in Rehovot, Israel, is a pharmaceutical company with a dual focus. Firstly, it develops injectable treatments, notably RZL-012, a novel synthetic small molecule designed to reduce fat tissue by causing fat cell death at the injection site. This drug is currently in clinical trials for various fat tissue indications and aesthetics. Secondly, Raziel Health offers a patient monitoring platform that uses artificial intelligence and machine learning to support remote patient care, enabling healthcare providers to improve patient outcomes across a wide range of conditions. The company's mission is to provide world-class, affordable healthcare in the comfort of patients' homes.

Raziel Health, established in 2012 and headquartered in Rehovot, Israel, is a pharmaceutical company with a dual focus. Firstly, it develops injectable treatments, notably RZL-012, a novel synthetic small molecule designed to reduce fat tissue by causing fat cell death at the injection site. This drug is currently in clinical trials for various fat tissue indications and aesthetics. Secondly, Raziel Health offers a patient monitoring platform that uses artificial intelligence and machine learning to support remote patient care, enabling healthcare providers to improve patient outcomes across a wide range of conditions. The company's mission is to provide world-class, affordable healthcare in the comfort of patients' homes.

Aleph Farms Limited is an innovative food technology company based in Ashdod, Israel, specializing in cellular agriculture to produce clean meat. Founded in 2017, Aleph Farms focuses on sustainable food production by developing methods to grow animal products directly from non-genetically modified animal cells, utilizing proprietary three-dimensional bioprinting technologies. The company made significant strides in the industry by unveiling the world's first cultivated thin-cut steak in 2018, followed by the first cultivated ribeye steak in 2021 and cultivated collagen in 2022. Under its product brand Aleph Cuts, its inaugural offering, the Petit Steak, is crafted from non-modified cells sourced from a premium Angus cow, allowing production without animal slaughter. Aleph Farms has garnered recognition for its commitment to climate leadership, including a net zero pledge made in 2020, earning accolades from prominent organizations like the World Economic Forum and the United Nations.

Magnisity is a technology developer focused on creating innovative solutions for minimally invasive surgeries and medical devices. Established in 2018 in Or Yehuda, Israel, by Benny Greenburg and Ron Barak, the company specializes in using advanced algorithms to design hardware, develop software, and engineer precise mechanical systems. Magnisity's platform aims to assist surgeons and patients by addressing significant challenges in the field of endoluminal interventions, ultimately seeking to enhance the standards of surgical procedures.

Hairstetics Ltd. is a medical device company based in Omer, Israel, specializing in the development, manufacturing, and marketing of advanced hair restoration devices. Established in 2010, the company focuses on providing innovative solutions for hair loss, including both surgical hair transplantation and non-surgical options. Hairstetics offers a diverse range of hair implantations, allowing customers to choose from various colors, styles, and lengths. Their products are designed to simplify the implantation process, reduce recovery times, and deliver enhanced aesthetic outcomes at a more affordable price compared to traditional methods, thus catering to individuals seeking effective treatments for hair loss.

CliClap Ltd., founded in 2016 and based in Kfar Saba, Israel, specializes in developing a content marketing utility for web browsers. This tool enhances audience engagement, brand awareness, and helps businesses achieve their goals by adding calls to action, scheduling posts, and analyzing success metrics. CliClap's AI-powered solution guides visitors through personalized content journeys, optimizing lead generation and qualification without manual management. The platform integrates seamlessly with existing marketing automation, CRM, social media management tools, and other systems, enabling more efficient marketing efforts and increasing conversion rates by at least 150%.

CliClap Ltd., founded in 2016 and based in Kfar Saba, Israel, specializes in developing a content marketing utility for web browsers. This tool enhances audience engagement, brand awareness, and helps businesses achieve their goals by adding calls to action, scheduling posts, and analyzing success metrics. CliClap's AI-powered solution guides visitors through personalized content journeys, optimizing lead generation and qualification without manual management. The platform integrates seamlessly with existing marketing automation, CRM, social media management tools, and other systems, enabling more efficient marketing efforts and increasing conversion rates by at least 150%.

Cordio Medical LTD. is an innovative healthcare company based in Or Yehuda, Israel, founded in 2013. It specializes in developing a mobile application that leverages advanced speech processing technology to monitor patients with congestive heart failure. The platform enables near real-time monitoring and early detection of health deterioration through the analysis of patients' voice recordings. By transcribing patients' free speech into actionable insights, Cordio Medical assists healthcare providers in identifying and mitigating worsening conditions, ultimately aiming to prevent unnecessary hospitalizations and promote patient well-being. The company's approach integrates machine learning capabilities tailored to individual patients, enhancing the effectiveness of remote health monitoring and support.

Cordio Medical LTD. is an innovative healthcare company based in Or Yehuda, Israel, founded in 2013. It specializes in developing a mobile application that leverages advanced speech processing technology to monitor patients with congestive heart failure. The platform enables near real-time monitoring and early detection of health deterioration through the analysis of patients' voice recordings. By transcribing patients' free speech into actionable insights, Cordio Medical assists healthcare providers in identifying and mitigating worsening conditions, ultimately aiming to prevent unnecessary hospitalizations and promote patient well-being. The company's approach integrates machine learning capabilities tailored to individual patients, enhancing the effectiveness of remote health monitoring and support.

NeuroApplied Ltd., founded in June 2016 and based in Hadera, Israel, specializes in customer-focused market research services that leverage the study of the collective subconscious. The company utilizes a SaaS-based platform that incorporates machine learning and neural network computing to analyze data collected through online picture games. This innovative approach allows NeuroApplied to provide valuable insights into subconscious brand perception, enabling brand managers to assess brand equity, track brand properties, and manage crises effectively. The platform features an intuitive dashboard that offers a nonintrusive and visually engaging experience for respondents, facilitating the collection of data that reflects customers' true thoughts and feelings.

Eximo Medical Ltd. is an innovative company based in Modi'in-Maccabim-Re'ut, Israel, specializing in hybrid catheter technology for tissue resection in vascular and gastrointestinal endoluminal applications. Founded in 2012, Eximo has developed a proprietary single-use hybrid catheter known as CatHI, which integrates optical fibers that emit short laser pulses and a blunt mechanical knife. This advanced technology aims to enhance safety and performance during medical procedures, particularly in atherectomy, by minimizing the risk of vessel perforation. As of October 2019, Eximo Medical operates as a subsidiary of AngioDynamics, Inc.

SinuSafe Medical is an innovative medical device company headquartered in Tel Aviv, Israel, founded in 2014. The company specializes in developing a nano-debrider device designed to address sinus-related issues without the need for surgical intervention. This device enables the irrigation and aspiration of the sinuses, providing a non-invasive solution for patients suffering from chronic sinusitis. By allowing sinus lavage to be performed in a physician's office, SinuSafe Medical aims to deliver immediate relief to ear, nose, and throat (ENT) patients, enhancing their overall treatment experience.

Cordio Medical LTD. is an innovative healthcare company based in Or Yehuda, Israel, founded in 2013. It specializes in developing a mobile application that leverages advanced speech processing technology to monitor patients with congestive heart failure. The platform enables near real-time monitoring and early detection of health deterioration through the analysis of patients' voice recordings. By transcribing patients' free speech into actionable insights, Cordio Medical assists healthcare providers in identifying and mitigating worsening conditions, ultimately aiming to prevent unnecessary hospitalizations and promote patient well-being. The company's approach integrates machine learning capabilities tailored to individual patients, enhancing the effectiveness of remote health monitoring and support.

ShapeDo Ltd. is a software development company based in Modi'in-Maccabim-Re'ut, Israel, founded in 2014. The company specializes in managing the implications of plan changes in construction projects through its cloud-based platform. ShapeDo's software facilitates comprehensive management of design changes, ensuring that all alterations are accurately reflected in contracts, budgets, and agreements. It provides functionalities such as blueprint version tracking, version comparison, and the generation of court-ready pricing reports, requests for information (RFIs), and claims. ShapeDo has been involved in significant infrastructure projects, including international airports, underground train systems, hospitals, and data centers, while also catering to smaller commercial and residential endeavors. Its solutions empower clients to navigate the complexities of design modifications and make necessary operational and financial adjustments seamlessly.

Jobrain Ltd. is a cloud-based hiring software provider based in Herzliya, Israel, designed to streamline the recruitment process for HR professionals and candidates. The platform enables candidates to apply for jobs easily while assisting HR teams in quickly identifying and hiring suitable talent. Jobrain features an open marketplace that offers a range of talent acquisition services, including job post distribution, remote and one-way video interviews, and candidate assessments. The company caters to head-hunters, agencies, and various hiring services, facilitating access to over 100,000 job positions, primarily in software development and startups. By leveraging data science, Jobrain simplifies the hiring process through a single interface, allowing clients to focus on essential tasks while minimizing administrative burdens.

Zuznow is an Israeli company founded in 2009 that specializes in mobile adaptation solutions for websites. Its platform automates the analysis of a website's visual structure and adapts it for optimal viewing on smartphones, facilitating a seamless mobile experience. Zuznow's technology serves a diverse clientele, including notable companies such as VentureBeat, HOOP, Newsgeek, and BAKER TILLY. The platform offers rapid mobile application development capabilities, allowing businesses to efficiently create secure mobile applications from complex web structures. This comprehensive solution supports various enterprise applications, including B2B, B2C, and B2E, effectively reducing development time and costs by over 90%. Zuznow positions itself as a key resource for organizations looking to implement a sustainable mobile strategy in response to the increasing demand for mobile-friendly solutions.

Marketyze is a technology company specializing in e-commerce market intelligence for the retail industry. Founded in December 2011 in Israel by Onn Manelson and Nave Ronen, the company provides a cloud-based platform that offers semantic site search and online price comparison solutions. Its pricing intelligence software tracks and analyzes competitor pricing, market trends, and internal data, enabling retailers to understand the impact of pricing events on sales performance. By leveraging this information, companies can refine their pricing strategies to enhance both sales and profitability.

ArTack Medical is a privately held medical device company based in Haifa, Israel, established in 2013. The company focuses on developing innovative tools for the invasive surgery market, particularly through its patented drive platform that enables the delivery of torque via a 5mm shaft. ArTack Medical's key product is an articulated hernia mesh fixation device designed to facilitate both laparoscopic and open surgical repairs. This device is compatible with any currently available mesh and allows surgeons to maintain their standard surgical techniques, thus enhancing operational efficiency without necessitating changes to established procedures.

CartiHeal Ltd. is a medical device company based in Kfar Sava, Israel, specializing in the development of innovative solutions for cartilage and bone disorders. Founded in 2009, the company has pioneered a cell-free implant technology known as Agili-C, designed to address focal articular cartilage and osteochondral defects. This off-the-shelf implant promotes the regeneration of true hyaline cartilage and its underlying subchondral bone through a minimally invasive procedure, without the need for cells or growth factors. CartiHeal's Agili-C implant represents a significant advancement in the treatment of cartilage injuries, which can lead to severe pain, disability, and early onset of osteoarthritis if left untreated. By offering a well-tolerated and effective solution, CartiHeal aims to meet a critical need in the field of cartilage repair and regeneration.

Eximo Medical Ltd. is an innovative company based in Modi'in-Maccabim-Re'ut, Israel, specializing in hybrid catheter technology for tissue resection in vascular and gastrointestinal endoluminal applications. Founded in 2012, Eximo has developed a proprietary single-use hybrid catheter known as CatHI, which integrates optical fibers that emit short laser pulses and a blunt mechanical knife. This advanced technology aims to enhance safety and performance during medical procedures, particularly in atherectomy, by minimizing the risk of vessel perforation. As of October 2019, Eximo Medical operates as a subsidiary of AngioDynamics, Inc.

Valire is a software solution company based in HaMerkaz, Israel, founded in 2009, that specializes in artificial intelligence applications for fraud detection and risk assessment. The company focuses on developing innovative software that protects businesses' assets and reputations by identifying fraudulent behavior through a combination of business rules and symbolic machine learning. Valire's technology aims to minimize false positives and presents a cost-effective implementation, helping organizations reduce operational risks while optimizing their performance and growth opportunities.

CartiHeal Ltd. is a medical device company based in Kfar Sava, Israel, specializing in the development of innovative solutions for cartilage and bone disorders. Founded in 2009, the company has pioneered a cell-free implant technology known as Agili-C, designed to address focal articular cartilage and osteochondral defects. This off-the-shelf implant promotes the regeneration of true hyaline cartilage and its underlying subchondral bone through a minimally invasive procedure, without the need for cells or growth factors. CartiHeal's Agili-C implant represents a significant advancement in the treatment of cartilage injuries, which can lead to severe pain, disability, and early onset of osteoarthritis if left untreated. By offering a well-tolerated and effective solution, CartiHeal aims to meet a critical need in the field of cartilage repair and regeneration.

Valtech Cardio Ltd. is a medical device company based in Or Yehuda, Israel, founded in 2006. It specializes in the development and manufacturing of cardiovascular devices aimed at treating mitral and tricuspid valve regurgitation through minimally invasive techniques. The company’s flagship products include the Cardioband System, which reconstructs the mitral valve via transfemoral direct annuloplasty, and the Cardiovalve system, designed for transfemoral transseptal mitral valve replacement. Additionally, Valtech offers the Cardinal, an adjustable annuloplasty ring that allows surgeons to optimize valve repair during surgery. The company is also advancing its pipeline with products like Cardioband Tricuspid, aimed at mitral regurgitation treatment, and the V-Chordal, which addresses mitral valve prolapse. Valtech Cardio operates as a subsidiary of Zeppelin Zox Ltd.

Kailight Photonics develops optical modules for the telecommunications industry. It offers tunable optical signal regenerator, an optical component that operates with regenerators, optical switches, add/drop multiplexers, and cross-connects. The company's optical transmission, signal regeneration, and wavelength conversion technology provides optical-networking solutions for systems vendors. It provides its products to long-haul network market segments. The company, formerly known as Chilight Technologies, was founded in 2000 and is headquartered in Rehovot, Israel with an additional office in Dallas, Texas. As of May 15, 2007, Kailight Photonics, Inc. operates as a subsidiary of Optium Corporation.