Pontifax

Camel-IDS develops radiopharmaceuticals for cancer patients. Its product, CAM-H2, treats HER2 positive cancers. It also engages in clinical development to treat breast cancer patients; and develops compounds for other cancer indications. The company was incorporated in 2014 and is based in Brussels, Belgium.

Armgo Pharma, Inc. is a biopharmaceutical company focused on developing small-molecule therapeutics for debilitating cardiac, skeletal muscular, and neurological disorders. The company specializes in calcium release channel stabilizers known as Rycals, which target the ryanodine receptor/calcium release channel located on the sarcoplasmic/endoplasmic reticulum of cells. These therapeutics are designed to address various conditions, including chronic heart failure, cardiac arrhythmias, muscle disorders, cognitive disorders, malignant hyperthermia, diabetes, chronic obstructive pulmonary disease, high blood pressure, and bladder dysfunction. Founded in 2004, Armgo Pharma is headquartered in Tarrytown, New York, with an additional office in New York City.

Anaveon AG is a biopharmaceutical company based in Bottmingen, Switzerland, founded in 2017. The company specializes in developing biologics that modulate cytokine functions, particularly focusing on next-generation IL-2 complexes. These complexes selectively enhance effector T cell functions, acting as effective immune adjuvants with a broad therapeutic window. Anaveon's innovative compounds demonstrate significant preclinical efficacy against cancer, both as standalone treatments and in combination with other therapies. The company's mission is to transform cytokines into life-saving treatments for patients suffering from various diseases characterized by immune system dysfunction. Through its targeted approach, Anaveon aims to provide substantial therapeutic benefits to cancer patients and others affected by immune pathology.

Emergence Therapeutics AG develops novel antibody drug conjugate (ADC) immuno-therapeutics to treat high need cancers. The company was incorporated in 2019 and is based in Duisburg, Germany.

Antios Therapeutics, Inc. is a biopharmaceutical company based in Atlanta, Georgia, founded in 2018. The company focuses on developing innovative therapies for viral diseases, particularly through its oral drug candidate, ATI-2173, aimed at treating patients infected with Hepatitis B and Hepatitis D viruses. With a leadership team that possesses extensive experience in the field, Antios Therapeutics is dedicated to advancing its research and development efforts toward potentially curative treatments for Hepatitis B virus infections.

Amolyt Pharma is a clinical-stage biotechnology company focused on developing peptide-based therapies for rare endocrine and metabolic disorders. The company's leading programs include AZP-3601, a parathyroid hormone analog aimed at treating hypoparathyroidism by maintaining sustained calcium levels in the blood, and AZP-3404, which features a novel mechanism of action that may help restore fat and glucose metabolism. Through its innovative approach, Amolyt Pharma seeks to provide effective treatments for patients suffering from critical and rare metabolic conditions.

Theseus Pharmaceuticals is a Technology based company.

Antios Therapeutics, Inc. is a biopharmaceutical company based in Atlanta, Georgia, founded in 2018. The company focuses on developing innovative therapies for viral diseases, particularly through its oral drug candidate, ATI-2173, aimed at treating patients infected with Hepatitis B and Hepatitis D viruses. With a leadership team that possesses extensive experience in the field, Antios Therapeutics is dedicated to advancing its research and development efforts toward potentially curative treatments for Hepatitis B virus infections.

Step Pharma, founded in 2014 and based in Paris, France, is a biopharmaceutical company specializing in the development of novel small molecule therapeutics for immunosuppressive therapies aimed at treating autoimmune diseases. A spin-off of the Imagine Institute, Step Pharma emerged from research led by Professor Alain Fischer on genetic immunodeficiencies. The company collaborates with Sygnature Discovery, a prominent drug discovery services provider, and Kurma Partners, an investor focused on healthcare and biotechnology in Europe. Its proprietary therapeutics utilize a unique class of oral nucleotide synthesis inhibitors that specifically target cytidine triphosphate synthase 1 (CTPS1). This approach allows for the selective modulation of immune cell populations, such as T and B cells, enhancing treatment efficacy and improving therapeutic outcomes for patients with autoimmune disorders.

StrideBio, Inc. is a gene therapy company based in Durham, North Carolina, specializing in the development of adeno-associated viral (AAV) vector technologies and therapeutics aimed at treating rare diseases. Founded in 2015, the company employs a unique STRucture Inspired DEsign approach that merges structural knowledge with accelerated evolution to create innovative AAV capsids. This technology is designed to evade neutralizing antibodies, thereby enhancing gene transfer efficiency. StrideBio's platform supports various gene therapy modalities, including gene addition, gene silencing, and gene editing, with applications across a range of rare genetic disorders.

EyeYon Medical Ltd. is an Israeli company specializing in the development of medical devices for the treatment of corneal edema. Founded by a team of experienced professionals in ophthalmology and business, the company is based in Jerusalem and operates within the Van Leer Technology Incubator. Its key products include Hyper-CL, a hyperosmotic contact lens that utilizes osmosis to extract fluids from corneal edema, thereby improving vision and alleviating pain. Additionally, EyeYon Medical offers DSPEK, an artificial endothelial layer designed to replace damaged endothelial tissue, which is crucial in cases of corneal edema. The company's innovative solutions are non-invasive, comfortable, and facilitate effective eye care for patients dealing with both acute and chronic ocular conditions.

AgomAb is developing molecular therapies for the regeneration of damaged tissues. Their unique agonistic monoclonal antibody molecules (“agomAbs”) stimulate molecular and cellular repair mechanisms that have the potential to restore organ function in patients with fibrotic, inflammatory, autoimmune and degenerative diseases.

AgomAb is developing molecular therapies for the regeneration of damaged tissues. Their unique agonistic monoclonal antibody molecules (“agomAbs”) stimulate molecular and cellular repair mechanisms that have the potential to restore organ function in patients with fibrotic, inflammatory, autoimmune and degenerative diseases.

Abcuro, Inc. is focused on developing immunotherapies aimed at treating autoimmunity and cancer. Incorporated in 2015 and based in Newton, Massachusetts, the company specializes in creating therapeutic antibodies that target novel aspects of the immune system. By employing advanced bioinformatics and analyzing transcription data from human diseases, Abcuro identifies new therapeutic targets and validates them through ex-vivo studies in diseased tissues. This innovative approach aims to enhance treatment strategies and improve patient outcomes in the fields of autoimmunity and oncology.

Stargazer Pharmaceuticals Inc. is a biopharmaceutical company based in Boston, Massachusetts, founded in 2018. The company specializes in developing and manufacturing therapies for rare eye diseases, with a particular focus on Stargardt’s disease, a form of juvenile retinal degeneration. Currently operating in stealth mode, Stargazer Pharmaceuticals aims to provide novel treatment options for conditions that lack existing therapies, thus enabling healthcare professionals to better address the needs of patients with these rare diseases.

Opiant Pharmaceuticals is a specialty pharmaceutical company focused on developing medicines for addiction and drug overdose. Headquartered in Santa Monica, California, the company offers NARCAN nasal spray, which is designed to reverse opioid overdoses. Opiant's product pipeline includes treatments for opioid overdose, alcohol use disorders, acute cannabinoid overdose, and opioid use disorders. Founded in 2005 and originally named Lightlake Therapeutics, the company changed its name to Opiant Pharmaceuticals in January 2016. Opiant was established by Dr. David Sinclair, who conducted pioneering research that highlighted the potential of opioid antagonists as a treatment for alcoholism.

Allena Pharmaceuticals is developing and commercializing non-systemic protein therapeutics to treat metabolic and orphan diseases, with a particular focus on nephrology and urologic conditions. Its proprietary technological approach enables the design, formulation, and delivery of non-absorbed and stable enzymes orally and in sufficient doses for activity in the GI tract. It was founded in 2011 and headquartered in Newton, Massachusetts.

Silverback Therapeutics, Inc. is a clinical-stage biopharmaceutical company based in Seattle, Washington, focused on developing tissue-targeted therapeutics for cancer, chronic viral infections, and other serious diseases. The company's lead product candidate, SBT6050, is currently in a Phase I/Ib clinical trial. It is a TLR8 agonist linker-payload conjugated to a HER2-directed monoclonal antibody, specifically targeting tumors such as breast, gastric, and non-small cell lung cancers. Additionally, Silverback is advancing SBT6290, a preclinical candidate that targets Nectin4, expressed in various cancers, and SBT8230, aimed at treating chronic hepatitis B virus infection. Utilizing its proprietary ImmunoTAC technology, Silverback aims to develop a new generation of therapies that can be systemically delivered yet act locally at disease sites, thereby modulating critical disease pathways that were previously considered inaccessible.

Novellus is a biotechnology company working to develop engineered cellular medicines. The company uses its non-immunogenic mRNA molecules to reprogram and gene-edit cells safely, and with high efficiency. They engineer precision medicines for patient segments and select from its technology toolbox for in vivo, ex vivo, allogeneic and autologous delivery. Novellus platform enables the high-level expression of gene-editing and cell-reprogramming proteins for high-specificity gene repair and both autologous and allogeneic cell therapies. The company is advancing its lead program, a breakthrough therapy for a rare dermatologic disease, through pre-clinical studies. Novellus was founded in 2015 and is headquartered in Cambridge, Massachusetts, United States.

V-Wave Ltd. is a medical technology company based in Caesarea, Israel, with additional offices in the United States. Founded in 2009, it specializes in the development of percutaneous implantable therapeutic devices aimed at treating chronic heart failure (HF) patients, which is a major cause of morbidity and mortality worldwide. The company has created the V-Wave Shunt, a biocompatible inter-atrial unidirectional implant designed for patients with both preserved and reduced ejection fractions, addressing the needs of those who experience disabling symptoms despite optimal medical therapy. V-Wave's innovative approach focuses on relieving symptoms, reducing hospitalizations, enhancing exercise capacity, and improving overall quality of life for HF patients. The organization is backed by a team of experienced engineers and medical scientists who have a proven track record in developing and bringing various implantable cardiovascular devices to market.

NovellusDx, Ltd. is a biotechnology company based in Jerusalem, Israel, established in 2011 by Haim Gil-ad and Yoram Altschuler. The company specializes in developing targeted therapies for cancer patients by focusing on tumor-specific driver mutations. NovellusDx utilizes innovative testing methods to evaluate the effectiveness of targeted therapy drugs on emulated tumors, allowing for the quantification of therapeutic effects. The company also monitors the oncogenic activity of relevant genes and proteins in patients, assessing changes before and after drug administration. Additionally, NovellusDx develops assays to detect the misregulated translocation of mutated signaling proteins to the nucleus, measuring the impact of drug candidates on specific tumors, particularly concerning their ability to inhibit the translocation of up-regulated signaling proteins.

Neogene Therapeutics, Inc. is a biotechnology company based in New York that focuses on the development of T cell therapies to treat cancer. Founded in 2018, the company specializes in creating personalized engineered T-cells that target neo-antigens, which are mutated proteins resulting from DNA alterations in cancer cells. Neogene's innovative platform allows for the isolation of T cell receptor (TCR) genes specific to these neo-antigens from tumor biopsies, which are routinely collected from patients. By utilizing advanced DNA sequencing and genetic screening technologies, Neogene can accurately identify and engineer TCRs that enhance the ability of T-cells to detect and eliminate cancer cells. This approach aims to improve treatment outcomes for cancer patients by providing therapies tailored to their unique tumor profiles.

Saniona is a research and development company with low burn rate, a world class team and high ambitions.

Vico Therapeutics B.V. is a biotechnology company based in Leiden, the Netherlands, founded in 2019. It specializes in developing RNA modulating therapies aimed at treating rare neurological disorders. The company's primary focus includes spinocerebellar ataxias, Huntington's disease, and Rett syndrome, which are characterized by progressive neurological decline and developmental challenges. Vico Therapeutics is committed to discovering and delivering innovative treatments that address the unmet medical needs of patients suffering from these severe conditions. Through its research and development efforts, the company seeks to provide effective therapeutic options for individuals affected by these disorders.

ProQR Therapeutics N.V. is a biopharmaceutical company focused on the discovery and development of RNA-based therapeutics aimed at treating genetic disorders. The company is advancing several key product candidates, including sepofarsen, currently in a phase II/III trial for Leber’s congenital amaurosis type 10, and QR-421a, which is in a phase 1/2 trial for Usher syndrome type 2 and non-syndromic retinitis pigmentosa. Additionally, QR-1123 is in a phase 1/2 trial for autosomal dominant retinitis pigmentosa, while QR-504a is undergoing its first clinical trial for Fuchs endothelial corneal dystrophy. ProQR Therapeutics has established collaboration agreements with prominent institutions such as General Hospital Corporation and Radboud University Medical Center. Founded in 2012, the company is headquartered in Leiden, the Netherlands.

Mereo is based in London and was founded in March 2015 to fund and develop novel, innovative specialist focused products from large pharmaceutical or biotechnology companies. Pharmaceutical companies face increasingly difficult choices in the allocation of internal resources to their drug development programs. With significant P&L constraints and rich pipelines it has become increasingly difficult for many companies to fully fund and advance development all of their drug candidates, especially beyond Phase 2. Mereo has been formed to take advantage of the global pharmaceutical industry's drive for creative ways to progress their clinical development pipelines. Mereo has acquired an initial mid-late stage portfolio of three exceptionally well characterised novel products for the treatment of diseases with considerable unmet medical need from Novartis Pharmaceuticals. Each of these programmes has a comprehensive dataset for both pre-clinical and proof-of-concept clinical studies. Additional product opportunities are under evaluation. Mereo's focus is the development of innovative medicines that have the potential to significantly transform the lives of patients suffering from rare and other specialised conditions around the world. To do this, the Company depends on the combination of its team's expertise in selecting and acquiring product opportunities, creating value in the development pipeline and structuring creative transactions. Mereo's internal expertise is complemented by a unique partnership with a leading global CRO, ICON. Mereo combines the operational discipline and efficiency of a small company with the financial resources to conduct comprehensive clinical studies. Mereo will rapidly progress each of the products through further value inflection points before partnering or divesting its products. The Company also has the option to directly commercialise products, for example in orphan disease indications.

Dynacure is a clinical-stage drug development company focused on improving the lives of patients with rare and orphan diseases.The Dynacure team leverages its proven track record in rare disease drug development to build a pipeline of novel drugs. Dynacure is developing DYN101, an investigational antisense medicine designed to modulate the expression of dynamin 2 for the treatment of Centronuclear Myopathies, with Ionis Pharmaceuticals. Dynacure is also building a complementary research portfolio targeting other orphan disorders.

Silverback Therapeutics, Inc. is a clinical-stage biopharmaceutical company based in Seattle, Washington, focused on developing tissue-targeted therapeutics for cancer, chronic viral infections, and other serious diseases. The company's lead product candidate, SBT6050, is currently in a Phase I/Ib clinical trial. It is a TLR8 agonist linker-payload conjugated to a HER2-directed monoclonal antibody, specifically targeting tumors such as breast, gastric, and non-small cell lung cancers. Additionally, Silverback is advancing SBT6290, a preclinical candidate that targets Nectin4, expressed in various cancers, and SBT8230, aimed at treating chronic hepatitis B virus infection. Utilizing its proprietary ImmunoTAC technology, Silverback aims to develop a new generation of therapies that can be systemically delivered yet act locally at disease sites, thereby modulating critical disease pathways that were previously considered inaccessible.

Keros Therapeutics, Inc. is a clinical-stage biopharmaceutical company dedicated to developing novel treatments for patients with hematological and musculoskeletal disorders that have significant unmet medical needs. The company's lead product candidate, KER-050, targets low blood cell counts, including anemia and thrombocytopenia, in patients with myelodysplastic syndromes and myelofibrosis. Additionally, Keros is advancing KER-047, a small molecule therapeutic in Phase 1 clinical trials, aimed at treating anemia related to elevated hepcidin levels and fibrodysplasia ossificans progressiva. The company's third candidate, KER-012, focuses on disorders associated with bone loss, such as osteoporosis and osteogenesis imperfecta, as well as pulmonary arterial hypertension. Founded in 2015 and based in Lexington, Massachusetts, Keros Therapeutics is recognized for its expertise in the role of the Transforming Growth Factor-Beta family of proteins, which regulate red blood cell and platelet production, along with muscle and bone maintenance.

PACT Pharma, Inc. is engaged in developing personalized cell-based therapies aimed at treating cancer, specifically through neoantigen-specific adoptive TCR T-cell therapies for solid tumors. The company utilizes advanced bioinformatics to analyze patients' tumor and normal DNA and RNA, identifying neoantigen peptides that provoke targeted T cell responses against cancer cells. By recognizing neo-epitopes, which are unique mutations in each patient's cancer, PACT Pharma creates autologous T cells engineered to specifically target and eliminate tumors expressing these neo-antigens. Founded in 2016 and headquartered in South San Francisco, California, PACT Pharma is focused on innovative approaches to enhance cancer treatment through tailored immunotherapies.

Eyevensys S.A.S. is a Paris-based company that specializes in non-viral gene therapy for ophthalmology. Founded in 2008, it focuses on developing innovative solutions to improve drug delivery methods for ocular diseases. The company utilizes its proprietary Electro-Transfection (ET) technology to administer plasmids to the ciliary muscle, allowing for the sustained release of therapeutic proteins directly into the vitreous, addressing conditions such as uveitis, age-related macular degeneration, and various retinopathies, including central retinal vein occlusion and diabetic retinopathy. Eyevensys aims to overcome the limitations of current treatment options, which often involve invasive procedures like intravitreal injections and surgeries. By enhancing compliance, ocular bioavailability, and tolerability, Eyevensys seeks to create a robust product pipeline that delivers improved clinical outcomes while minimizing the need for frequent and invasive interventions.

Metabomed is a drug discovery company focused on developing treatments for cancer by targeting the unique metabolic pathways of cancer cells. Utilizing a proprietary platform that integrates computational biology, genomics, and metabolomics, Metabomed identifies specific metabolic alterations associated with cancer growth. The company's small molecule drugs are designed to halt the proliferation of reprogrammed cancer cells, which allows oncologists to initiate treatment more swiftly and enhances the chances of successful patient outcomes while minimizing harm to healthy tissues. Through its innovative approach, Metabomed aims to advance cancer treatment by addressing the metabolic characteristics that distinguish cancer cells from normal cells.

Raziel Health is focused on developing innovative treatments for obesity and fat disorders, particularly through its injectable drug RZL-012. This novel synthetic small molecule is designed to be injected directly into fat tissue, where it induces fat cell death, leading to a reduction in fat at the injection site. The company, founded in 2012 and based in Rehovot, Israel, aims to provide accessible and cost-effective healthcare solutions that enhance patient experience and promote timely clinical interventions. By integrating user-friendly technologies and leveraging data analytics, Raziel Health supports wellness and disease management, ensuring that individual patient goals are met effectively.

Adicet Bio is a biotechnology company focused on the discovery and development of allogeneic gamma delta T cell therapies for cancer and other diseases. The company is advancing its lead product candidate, ADI-001, which is a first-in-class allogeneic gamma delta T cell therapy designed to target CD20. This therapy aims to address relapsed or refractory aggressive B cell non-Hodgkin's lymphoma and potentially autoimmune diseases. Additionally, Adicet Bio is developing another preclinical candidate, ADI-270, which is an armored gamma delta CAR T cell therapy targeting renal cell carcinoma, with prospects for treating other solid tumors and hematological malignancies that express CD70.

Alizé Pharma is a group of privately held biopharmaceutical companies specializing in the development of innovative biopharmaceutical drugs, proteins, and peptides, for the treatment of metabolic diseases and cancer. It is based in Ecully, near Lyon, France. Its management is made up of a team of drug development experts and a board of directors offering wide international experience. Alizé Pharma has two programs, the AZP-3601, a PTH analog for hypoparathyroidism, and AZP-3404, a peptide leveraging the biology of IGFBP2 for the treatment of syndromes of acute insulin resistance. The company was founded on 2015.

Pi Therapeutics is a discovery-stage biopharmaceutical company aiming to develop a novel cancer drug. The company is financed by a syndicate of Takeda Pharmaceutical Company through its venture group Takeda Ventures Inc., Johnson & Johnson Innovation – JJDC, OrbiMed Israel Partners, Pontifax, and the Israel Innovation Authority, and has operated since March 2015 in the FutuRx biotech accelerator in Ness Ziona, Israel. The company’s mission is to develop novel first-in-class drugs directed against the ubiquitin-proteasome system (UPS), mainly for treatment of cancer.

AgomAb is developing molecular therapies for the regeneration of damaged tissues. Their unique agonistic monoclonal antibody molecules (“agomAbs”) stimulate molecular and cellular repair mechanisms that have the potential to restore organ function in patients with fibrotic, inflammatory, autoimmune and degenerative diseases.

AgomAb is developing molecular therapies for the regeneration of damaged tissues. Their unique agonistic monoclonal antibody molecules (“agomAbs”) stimulate molecular and cellular repair mechanisms that have the potential to restore organ function in patients with fibrotic, inflammatory, autoimmune and degenerative diseases.

Prevail Therapeutics Inc. is a biotechnology company based in New York that specializes in developing gene therapies for neurodegenerative diseases. Founded in 2017 with support from The Silverstein Foundation for Parkinson’s with GBA, REGENXBIO, and OrbiMed, the company is focused on creating innovative adeno-associated virus (AAV)-based treatments. Its lead candidate, PR001, is currently undergoing Phase I/II clinical trials aimed at treating Parkinson's disease linked to GBA1 mutations and neuronopathic Gaucher disease. Additionally, Prevail is developing PR006 for frontotemporal dementia associated with GRN mutations and PR004 for various synucleinopathies. The company is dedicated to advancing therapies that can modify the course of these debilitating conditions.

Keros Therapeutics, Inc. is a clinical-stage biopharmaceutical company dedicated to developing novel treatments for patients with hematological and musculoskeletal disorders that have significant unmet medical needs. The company's lead product candidate, KER-050, targets low blood cell counts, including anemia and thrombocytopenia, in patients with myelodysplastic syndromes and myelofibrosis. Additionally, Keros is advancing KER-047, a small molecule therapeutic in Phase 1 clinical trials, aimed at treating anemia related to elevated hepcidin levels and fibrodysplasia ossificans progressiva. The company's third candidate, KER-012, focuses on disorders associated with bone loss, such as osteoporosis and osteogenesis imperfecta, as well as pulmonary arterial hypertension. Founded in 2015 and based in Lexington, Massachusetts, Keros Therapeutics is recognized for its expertise in the role of the Transforming Growth Factor-Beta family of proteins, which regulate red blood cell and platelet production, along with muscle and bone maintenance.

Camel-IDS develops radiopharmaceuticals for cancer patients. Its product, CAM-H2, treats HER2 positive cancers. It also engages in clinical development to treat breast cancer patients; and develops compounds for other cancer indications. The company was incorporated in 2014 and is based in Brussels, Belgium.

89bio, Inc., a clinical-stage biopharmaceutical company, focuses on the development and commercialization of therapies for the treatment of liver and cardio-metabolic diseases. Its lead product candidate is BIO89-100, a glycoPEGylated analog of fibroblast growth factor 21 for the treatment of nonalcoholic steatohepatitis. The company also intends to develop BIO89-100 for the treatment of severe hypertriglyceridemia. 89bio, Inc. was founded in 2018 and is based in San Francisco, California.

Dynacure is a clinical-stage drug development company focused on improving the lives of patients with rare and orphan diseases.The Dynacure team leverages its proven track record in rare disease drug development to build a pipeline of novel drugs. Dynacure is developing DYN101, an investigational antisense medicine designed to modulate the expression of dynamin 2 for the treatment of Centronuclear Myopathies, with Ionis Pharmaceuticals. Dynacure is also building a complementary research portfolio targeting other orphan disorders.

V-Wave Ltd. is a medical technology company based in Caesarea, Israel, with additional offices in the United States. Founded in 2009, it specializes in the development of percutaneous implantable therapeutic devices aimed at treating chronic heart failure (HF) patients, which is a major cause of morbidity and mortality worldwide. The company has created the V-Wave Shunt, a biocompatible inter-atrial unidirectional implant designed for patients with both preserved and reduced ejection fractions, addressing the needs of those who experience disabling symptoms despite optimal medical therapy. V-Wave's innovative approach focuses on relieving symptoms, reducing hospitalizations, enhancing exercise capacity, and improving overall quality of life for HF patients. The organization is backed by a team of experienced engineers and medical scientists who have a proven track record in developing and bringing various implantable cardiovascular devices to market.

Prevail Therapeutics Inc. is a biotechnology company based in New York that specializes in developing gene therapies for neurodegenerative diseases. Founded in 2017 with support from The Silverstein Foundation for Parkinson’s with GBA, REGENXBIO, and OrbiMed, the company is focused on creating innovative adeno-associated virus (AAV)-based treatments. Its lead candidate, PR001, is currently undergoing Phase I/II clinical trials aimed at treating Parkinson's disease linked to GBA1 mutations and neuronopathic Gaucher disease. Additionally, Prevail is developing PR006 for frontotemporal dementia associated with GRN mutations and PR004 for various synucleinopathies. The company is dedicated to advancing therapies that can modify the course of these debilitating conditions.

ABAC Therapeutics S.A. develops precision antimicrobial agents for precision treatment of MDR Gram-negative infections. It offers PasNas, a drug discovery platform unveiling pathogen-specific antibacterial properties of molecules while promoting the compounds active against MDR strains with new mechanism of action and with maximized chances of success in clinical development. The company was incorporated in 2014 and is based in Barcelona, Spain. As of November 20, 2019, ABAC Therapeutics S.A. operates as a subsidiary of Tibidabo Ventures.

Step Pharma, founded in 2014 and based in Paris, France, is a biopharmaceutical company specializing in the development of novel small molecule therapeutics for immunosuppressive therapies aimed at treating autoimmune diseases. A spin-off of the Imagine Institute, Step Pharma emerged from research led by Professor Alain Fischer on genetic immunodeficiencies. The company collaborates with Sygnature Discovery, a prominent drug discovery services provider, and Kurma Partners, an investor focused on healthcare and biotechnology in Europe. Its proprietary therapeutics utilize a unique class of oral nucleotide synthesis inhibitors that specifically target cytidine triphosphate synthase 1 (CTPS1). This approach allows for the selective modulation of immune cell populations, such as T and B cells, enhancing treatment efficacy and improving therapeutic outcomes for patients with autoimmune disorders.

Keros Therapeutics, Inc. is a clinical-stage biopharmaceutical company dedicated to developing novel treatments for patients with hematological and musculoskeletal disorders that have significant unmet medical needs. The company's lead product candidate, KER-050, targets low blood cell counts, including anemia and thrombocytopenia, in patients with myelodysplastic syndromes and myelofibrosis. Additionally, Keros is advancing KER-047, a small molecule therapeutic in Phase 1 clinical trials, aimed at treating anemia related to elevated hepcidin levels and fibrodysplasia ossificans progressiva. The company's third candidate, KER-012, focuses on disorders associated with bone loss, such as osteoporosis and osteogenesis imperfecta, as well as pulmonary arterial hypertension. Founded in 2015 and based in Lexington, Massachusetts, Keros Therapeutics is recognized for its expertise in the role of the Transforming Growth Factor-Beta family of proteins, which regulate red blood cell and platelet production, along with muscle and bone maintenance.

Horama SAS is a biotechnology company based in Paris, France, established in 2014. It specializes in developing gene therapy products aimed at treating rare ophthalmic diseases, particularly targeting inherited retinal dystrophies and retinopathies. By utilizing recombinant adeno-associated viral vectors, Horama's therapies aim to deliver a functional copy of mutated genes to affected retinal cells. This approach seeks to restore normal cell function, prevent further deterioration of vision, and ultimately improve or restore visual capabilities for patients. The company is positioning itself as a significant player in the ophthalmic gene therapy sector, with the goal of enhancing patient autonomy while also contributing to reduced healthcare costs.

ArQule, Inc. is a clinical-stage biopharmaceutical company focused on developing targeted therapeutics for cancer and rare diseases. Based in Burlington, Massachusetts, the company utilizes its ArQule Kinase Inhibitor Platform to create innovative small molecule drugs. ArQule's pipeline includes several promising candidates, such as ARQ 531, a dual inhibitor of Bruton’s tyrosine kinase currently in Phase I trials for B-cell malignancies, and miransertib (ARQ 092), which targets the AKT pathway in advanced endometrial cancer patients. Additionally, ARQ 75 is under Phase I development for solid tumors with specific genetic mutations, while Derazantinib (ARQ 087) is in a registrational trial for intrahepatic cholangiocarcinoma. The company has established licensing agreements with Basilea Pharmaceutica and Roivant Sciences for its products. Founded in 1993, ArQule has positioned itself as a key player in the oncology space, aiming to improve patient outcomes through its specialized therapeutics. As of early 2020, ArQule operates as a subsidiary of Merck Sharp & Dohme Corp.

VBI Vaccines Inc. is a biopharmaceutical company focused on developing vaccines for infectious diseases and immuno-oncology, with operations in Israel, the United States, and internationally. The company offers Sci-B-Vac, a prophylactic hepatitis B vaccine suitable for various age groups, and is advancing VBI-2601, an immunotherapeutic candidate aimed at achieving a functional cure for chronic hepatitis B. Utilizing its enveloped virus-like particle (eVLP) platform technology, VBI develops vaccines that closely mimic target viruses to elicit strong immune responses. Key candidates in its eVLP program include VBI-1901, a glioblastoma vaccine in Phase I/IIa clinical trials, and VBI-1501, a cytomegalovirus vaccine that has completed Phase I trials. VBI Vaccines also engages in collaboration and licensing agreements with various pharmaceutical and biotechnology entities, including partnerships for the commercialization of its hepatitis B vaccine and the development of a pan-coronavirus vaccine candidate. Headquartered in Cambridge, Massachusetts, the company also has research facilities in Ottawa, Canada.

CathWorks Ltd. is a medical technology company based in Kfar-Saba, Israel, with an additional office in the United States. Founded in 2013, CathWorks specializes in developing advanced medical devices for the interventional cardiology market. The company's innovative technology leverages computational science and automatic multi-layered algorithms to enhance the utility of coronary angiography data, transforming visual assessments into objective decision-making tools for physicians. Its flagship product, CathWorks FFRangio, is a non-invasive device that provides objective multi-vessel physiological measurements, aimed at optimizing and confirming intra-procedural decisions for percutaneous coronary interventions (PCI). CathWorks is privately held and benefits from strong partnerships and support from leading venture capital firms in the medical devices sector.

Eloxx Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, focuses on developing novel ribonucleic acid modulating drug candidates for the treatment of rare and ultra-rare premature stop codon diseases. Its lead investigational drug product candidate is ELX-02, which is in Phase 2 clinical trial that focuses on the treatment of cystic fibrosis and nephropathic cystinosis patients with diagnosed nonsense mutations. The company was founded in 2013 and is headquartered in Waltham, Massachusetts.

LogicBio develops gene therapy vectors for previously incurable genetic and infectious diseases, including: hemophilia, HIV/AIDS and methylmalonic acidemia (MMA). Our proprietary technology based on the non-pathogenic Adeno-Associated Viral (AAV) vector offers superior efficiency and safety compared to all competitors on the market, and is uniquely suited for the treatment of children as well as adults.

Eloxx Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, focuses on developing novel ribonucleic acid modulating drug candidates for the treatment of rare and ultra-rare premature stop codon diseases. Its lead investigational drug product candidate is ELX-02, which is in Phase 2 clinical trial that focuses on the treatment of cystic fibrosis and nephropathic cystinosis patients with diagnosed nonsense mutations. The company was founded in 2013 and is headquartered in Waltham, Massachusetts.

Tisbury Pharmaceuticals, Inc. discovers, develops, and commercializes therapy to treat primary open angle glaucoma. The company's clinical candidate, R-801, accelerates flow via the trabecular meshwork via redox catalysis and K+-ATP (channel activation). The company was incorporated in 2017 and is based in Beverly, Massachusetts.

TargEDys SAS, established in 2011 and located in Rouen, France, focuses on developing innovative mechanisms to address eating disorders such as hyperphagia and anorexia. The company's approach involves hormone mimetic proteins associated with the gut microbiota to regulate appetite. By leveraging naturally occurring bacterial and hormonal mimetic proteins found in the gut, TargEDys aims to help individuals manage their eating behaviors effectively. This technology is designed to assist in controlling metabolic diseases by modulating appetite, thereby benefiting populations such as overweight individuals and those suffering from conditions like cachexia or anorexia.

EyeYon Medical Ltd. is an Israeli company specializing in the development of medical devices for the treatment of corneal edema. Founded by a team of experienced professionals in ophthalmology and business, the company is based in Jerusalem and operates within the Van Leer Technology Incubator. Its key products include Hyper-CL, a hyperosmotic contact lens that utilizes osmosis to extract fluids from corneal edema, thereby improving vision and alleviating pain. Additionally, EyeYon Medical offers DSPEK, an artificial endothelial layer designed to replace damaged endothelial tissue, which is crucial in cases of corneal edema. The company's innovative solutions are non-invasive, comfortable, and facilitate effective eye care for patients dealing with both acute and chronic ocular conditions.

ARTSaVIT is a biopharmaceuticals company developing a cancer drug.

Eyevensys S.A.S. is a Paris-based company that specializes in non-viral gene therapy for ophthalmology. Founded in 2008, it focuses on developing innovative solutions to improve drug delivery methods for ocular diseases. The company utilizes its proprietary Electro-Transfection (ET) technology to administer plasmids to the ciliary muscle, allowing for the sustained release of therapeutic proteins directly into the vitreous, addressing conditions such as uveitis, age-related macular degeneration, and various retinopathies, including central retinal vein occlusion and diabetic retinopathy. Eyevensys aims to overcome the limitations of current treatment options, which often involve invasive procedures like intravitreal injections and surgeries. By enhancing compliance, ocular bioavailability, and tolerability, Eyevensys seeks to create a robust product pipeline that delivers improved clinical outcomes while minimizing the need for frequent and invasive interventions.

Nutrinia Ltd. is a neonatology company focused on developing pharmaceuticals for rare gastrointestinal conditions in infants. The company’s primary clinical programs include NTRA-2112, which addresses intestinal malabsorption in preterm infants by improving enteral nutrition tolerance, enhancing growth velocity, and reducing the length of stay in neonatal intensive care units. Another key product, NTRA-9620, targets short bowel syndrome by promoting bowel adaptation after surgical resection and minimizing reliance on parenteral nutrition. Nutrinia’s innovative approach includes oral formulations of insulin to support gut rehabilitation in infants. Founded in 2003 and based in Ramat-Gan, Israel, Nutrinia is dedicated to improving health outcomes for vulnerable populations.

Arno Therapeutics, Inc. is a biopharmaceutical company dedicated to developing innovative treatments for cancer and other life-threatening diseases. The company's pipeline features several drug candidates, including Onapristone, a type 1 anti-progestin hormone blocker currently in Phase I/II clinical studies aimed at treating various solid tumors, including breast and endometrial cancers in post-menopausal women, as well as advanced castration-resistant prostate cancer in men. Another candidate, AR-12, has completed Phase I clinical studies for the treatment of solid tumors and hematological malignancies, and is also undergoing pre-clinical studies for various anti-microbial targets. Additionally, AR-42, an orally available therapy, is in Phase I investigator-initiated clinical studies for hematological malignancies and solid tumors. Arno Therapeutics has established license agreements with multiple institutions and a co-development agreement with Leica Biosystems Newcastle Ltd., and is headquartered in Flemington, New Jersey.

Entera Bio is developing novel oral drugs by utilizing its proprietary cutting edge delivery technology This technology protects large molecules and peptides in the GI tract. Oral drug delivery is the most straight forward and user friendly approach to medical treatment. Entera Bio has key personnel with the relevant know how, experience and networks working together to enable rapid development of its products. The company has an experienced management team with more than 50 years of combined drug development experience.

TargEDys SAS, established in 2011 and located in Rouen, France, focuses on developing innovative mechanisms to address eating disorders such as hyperphagia and anorexia. The company's approach involves hormone mimetic proteins associated with the gut microbiota to regulate appetite. By leveraging naturally occurring bacterial and hormonal mimetic proteins found in the gut, TargEDys aims to help individuals manage their eating behaviors effectively. This technology is designed to assist in controlling metabolic diseases by modulating appetite, thereby benefiting populations such as overweight individuals and those suffering from conditions like cachexia or anorexia.

Sweetch Health Ltd. is a company based in Jerusalem, Israel, focused on preventing chronic diseases such as diabetes, hypertension, hyperlipidemia, and obesity through its artificial intelligence-driven platform. Founded in 2013, Sweetch provides personalized recommendations tailored to individual behaviors, utilizing data from smartphones to gain insights into lifestyle habits. This technology predicts a person's three-year risk of developing metabolic syndrome-related diseases and implements interventions that emphasize emotional support and motivation to encourage long-term behavioral change. By offering scalable and cost-effective solutions, Sweetch aims to guide the prediabetic population toward healthier lifestyles and improve clinical outcomes for individuals managing chronic conditions, thus fostering continuous engagement with healthcare providers and other stakeholders.

Metabomed is a drug discovery company focused on developing treatments for cancer by targeting the unique metabolic pathways of cancer cells. Utilizing a proprietary platform that integrates computational biology, genomics, and metabolomics, Metabomed identifies specific metabolic alterations associated with cancer growth. The company's small molecule drugs are designed to halt the proliferation of reprogrammed cancer cells, which allows oncologists to initiate treatment more swiftly and enhances the chances of successful patient outcomes while minimizing harm to healthy tissues. Through its innovative approach, Metabomed aims to advance cancer treatment by addressing the metabolic characteristics that distinguish cancer cells from normal cells.

OCON Healthcare, also known as OCON Medical Ltd., focuses on the development, manufacturing, and commercialization of innovative women's health products utilizing its proprietary IUB (Intra Uterine Ball) platform. The company's flagship product, the IUB Ballerine, is a hormone-free, copper-based intrauterine contraceptive designed for up to five years of use. Additionally, OCON is advancing its SEAD product, currently in Phase II clinical studies, which aims to provide a disposable, point-of-care therapy for abnormal uterine bleeding. The company's offerings also include intrauterine devices designed for various indications, such as abnormal uterine bleeding and infertility. OCON Healthcare serves customers primarily in Europe, South Africa, and Israel. Founded in 2011, the company is headquartered in Modi'in-Maccabim-Re'ut, Israel, with an additional office in Zürich, Switzerland.

Adicet Bio is a biotechnology company focused on the discovery and development of allogeneic gamma delta T cell therapies for cancer and other diseases. The company is advancing its lead product candidate, ADI-001, which is a first-in-class allogeneic gamma delta T cell therapy designed to target CD20. This therapy aims to address relapsed or refractory aggressive B cell non-Hodgkin's lymphoma and potentially autoimmune diseases. Additionally, Adicet Bio is developing another preclinical candidate, ADI-270, which is an armored gamma delta CAR T cell therapy targeting renal cell carcinoma, with prospects for treating other solid tumors and hematological malignancies that express CD70.

Arno Therapeutics, Inc. is a biopharmaceutical company dedicated to developing innovative treatments for cancer and other life-threatening diseases. The company's pipeline features several drug candidates, including Onapristone, a type 1 anti-progestin hormone blocker currently in Phase I/II clinical studies aimed at treating various solid tumors, including breast and endometrial cancers in post-menopausal women, as well as advanced castration-resistant prostate cancer in men. Another candidate, AR-12, has completed Phase I clinical studies for the treatment of solid tumors and hematological malignancies, and is also undergoing pre-clinical studies for various anti-microbial targets. Additionally, AR-42, an orally available therapy, is in Phase I investigator-initiated clinical studies for hematological malignancies and solid tumors. Arno Therapeutics has established license agreements with multiple institutions and a co-development agreement with Leica Biosystems Newcastle Ltd., and is headquartered in Flemington, New Jersey.

V-Wave Ltd. is a medical technology company based in Caesarea, Israel, with additional offices in the United States. Founded in 2009, it specializes in the development of percutaneous implantable therapeutic devices aimed at treating chronic heart failure (HF) patients, which is a major cause of morbidity and mortality worldwide. The company has created the V-Wave Shunt, a biocompatible inter-atrial unidirectional implant designed for patients with both preserved and reduced ejection fractions, addressing the needs of those who experience disabling symptoms despite optimal medical therapy. V-Wave's innovative approach focuses on relieving symptoms, reducing hospitalizations, enhancing exercise capacity, and improving overall quality of life for HF patients. The organization is backed by a team of experienced engineers and medical scientists who have a proven track record in developing and bringing various implantable cardiovascular devices to market.

Otic Pharma is a clinical-stage pharmaceutical company focusing on the development and commercialization of products for disorders of the ear, nose, and throat (ENT). The company has two platform technologies, each of which has the potential to be developed for multiple ENT indications. The company is currently developing a nasally-administered, combination drug product (OP-02) intended to address the underlying cause of otitis media and Eustachian tube dysfunction (OM/ETD), a condition that affects more than 700 million people around the world every year. Otitis media is one of the most common disease seen in pediatric practice and the most frequent reason children consume antibiotics or undergo surgery. The company also has a foam-based drug delivery technology platform (OP-01) that can be used to deliver drugs into the ear, nose, and sinus cavities. The company is currently developing OP-01 as an improved treatment option for acute otitis externa (“swimmers ear”). For more information on the company, please visit www.oticpharma.com

EyeYon Medical Ltd. is an Israeli company specializing in the development of medical devices for the treatment of corneal edema. Founded by a team of experienced professionals in ophthalmology and business, the company is based in Jerusalem and operates within the Van Leer Technology Incubator. Its key products include Hyper-CL, a hyperosmotic contact lens that utilizes osmosis to extract fluids from corneal edema, thereby improving vision and alleviating pain. Additionally, EyeYon Medical offers DSPEK, an artificial endothelial layer designed to replace damaged endothelial tissue, which is crucial in cases of corneal edema. The company's innovative solutions are non-invasive, comfortable, and facilitate effective eye care for patients dealing with both acute and chronic ocular conditions.

OCON Healthcare, also known as OCON Medical Ltd., focuses on the development, manufacturing, and commercialization of innovative women's health products utilizing its proprietary IUB (Intra Uterine Ball) platform. The company's flagship product, the IUB Ballerine, is a hormone-free, copper-based intrauterine contraceptive designed for up to five years of use. Additionally, OCON is advancing its SEAD product, currently in Phase II clinical studies, which aims to provide a disposable, point-of-care therapy for abnormal uterine bleeding. The company's offerings also include intrauterine devices designed for various indications, such as abnormal uterine bleeding and infertility. OCON Healthcare serves customers primarily in Europe, South Africa, and Israel. Founded in 2011, the company is headquartered in Modi'in-Maccabim-Re'ut, Israel, with an additional office in Zürich, Switzerland.

Nutrinia Ltd. is a neonatology company focused on developing pharmaceuticals for rare gastrointestinal conditions in infants. The company’s primary clinical programs include NTRA-2112, which addresses intestinal malabsorption in preterm infants by improving enteral nutrition tolerance, enhancing growth velocity, and reducing the length of stay in neonatal intensive care units. Another key product, NTRA-9620, targets short bowel syndrome by promoting bowel adaptation after surgical resection and minimizing reliance on parenteral nutrition. Nutrinia’s innovative approach includes oral formulations of insulin to support gut rehabilitation in infants. Founded in 2003 and based in Ramat-Gan, Israel, Nutrinia is dedicated to improving health outcomes for vulnerable populations.

Check-Cap Ltd. is a clinical-stage medical diagnostics company based in Isfiya, Israel, focused on developing an innovative capsule-based system, C-Scan, for colorectal cancer screening. This system employs low-dose X-rays to detect polyps and masses, aiming to provide a non-invasive and preparation-free alternative to traditional colonoscopies. The C-Scan system includes three components: the C-Scan Cap, an ingestible capsule that collects and transmits structural information; the C-Scan Track, a biocompatible device worn by the patient for tracking and data recording; and C-Scan View, software that processes and visualizes the collected clinical data in 3D. Founded in 2004, Check-Cap aims to market its products in the United States, Europe, Israel, and Japan, targeting a significant need for accurate and accessible colorectal cancer screening solutions.

Arno Therapeutics, Inc. is a biopharmaceutical company dedicated to developing innovative treatments for cancer and other life-threatening diseases. The company's pipeline features several drug candidates, including Onapristone, a type 1 anti-progestin hormone blocker currently in Phase I/II clinical studies aimed at treating various solid tumors, including breast and endometrial cancers in post-menopausal women, as well as advanced castration-resistant prostate cancer in men. Another candidate, AR-12, has completed Phase I clinical studies for the treatment of solid tumors and hematological malignancies, and is also undergoing pre-clinical studies for various anti-microbial targets. Additionally, AR-42, an orally available therapy, is in Phase I investigator-initiated clinical studies for hematological malignancies and solid tumors. Arno Therapeutics has established license agreements with multiple institutions and a co-development agreement with Leica Biosystems Newcastle Ltd., and is headquartered in Flemington, New Jersey.

HeadSense Medical Ltd. is an early-stage company based in Netanya, Israel, focused on developing a non-invasive intracranial pressure (ICP) monitor. Founded in 2011, the company offers a validated and CE Mark approved device used in various medical settings including neurosurgery, neurology, emergency medicine, and critical care. In addition to its ICP monitor, HeadSense is working on expanding its platform to include diagnostic applications for cerebral vasospasm, concussion, and the quantification of traumatic brain injury severity. The company operates in both the United States and Israel, aiming to enhance brain diagnostics through its innovative technology.

V-Wave Ltd. is a medical technology company based in Caesarea, Israel, with additional offices in the United States. Founded in 2009, it specializes in the development of percutaneous implantable therapeutic devices aimed at treating chronic heart failure (HF) patients, which is a major cause of morbidity and mortality worldwide. The company has created the V-Wave Shunt, a biocompatible inter-atrial unidirectional implant designed for patients with both preserved and reduced ejection fractions, addressing the needs of those who experience disabling symptoms despite optimal medical therapy. V-Wave's innovative approach focuses on relieving symptoms, reducing hospitalizations, enhancing exercise capacity, and improving overall quality of life for HF patients. The organization is backed by a team of experienced engineers and medical scientists who have a proven track record in developing and bringing various implantable cardiovascular devices to market.

ReWalk Robotics Ltd. is a medical device company that specializes in the design, development, and commercialization of robotic exoskeletons aimed at individuals with mobility impairments. The company offers two primary products: the ReWalk Personal System, which supports everyday use for paraplegic individuals in various environments, including homes and workplaces, and the ReWalk Rehabilitation System, designed for therapeutic use in hospitals and rehabilitation centers. These systems enable users to walk, stand, sit, and navigate stairs, enhancing their quality of life. Additionally, ReWalk Robotics is developing ReWalk Restore, a soft suit exoskeleton intended for the rehabilitation of stroke patients. The company markets its products directly to healthcare providers and individuals, as well as through third-party distributors. Founded in 2001, ReWalk Robotics is headquartered in Yokneam Ilit, Israel, with operational facilities in Marlborough, Massachusetts.

UroGen Pharma Ltd., a clinical stage biopharmaceutical company, focuses on developing solutions for specialty cancers and urologic diseases. The company’s lead product candidates are UGN-101 and UGN-102, which are designed to ablate tumors by non-surgical means and to treat several forms of non-muscle invasive urothelial cancer that include low-grade upper tract urothelial carcinoma and low-grade non-muscle invasive bladder cancer. It is also developing UGN-201, a proprietary immunotherapy product candidate for the treatment of high-grade non-muscle invasive bladder cancer. The company has a license agreement with Allergan Pharmaceuticals International Limited for developing and commercializing pharmaceutical products that contain RTGel and clostridial toxins; and Agenus Inc. to develop, make, use, sell, import, and commercialize products of Agenus for the treatment of cancers of the urinary tract via intravesical delivery. UroGen Pharma Ltd. was founded in 2004 and is based in Princeton, New Jersey.

OCON Healthcare, also known as OCON Medical Ltd., focuses on the development, manufacturing, and commercialization of innovative women's health products utilizing its proprietary IUB (Intra Uterine Ball) platform. The company's flagship product, the IUB Ballerine, is a hormone-free, copper-based intrauterine contraceptive designed for up to five years of use. Additionally, OCON is advancing its SEAD product, currently in Phase II clinical studies, which aims to provide a disposable, point-of-care therapy for abnormal uterine bleeding. The company's offerings also include intrauterine devices designed for various indications, such as abnormal uterine bleeding and infertility. OCON Healthcare serves customers primarily in Europe, South Africa, and Israel. Founded in 2011, the company is headquartered in Modi'in-Maccabim-Re'ut, Israel, with an additional office in Zürich, Switzerland.

cCAM Biotherapeutics Ltd., a clinical stage company, engages in the discovery and development of novel immunotherapies to treat cancer. It offers CM-24, a humanized anti CEACAM1 monoclonal antibody that inhibits the immunosuppressive effect of CEAC AM1 for the treatment of advanced or recurrent malignancies, including melanoma, non-small-cell lung, bladder, gastric, colorectal, and ovarian cancers. cCAM Biotherapeutics Ltd. was founded in 2010 and is based in Misgav, Israel. As of July 31, 2015, cCAM Biotherapeutics Ltd operates as a subsidiary of Merck & Co. Inc.

MacroCure is a biotechnology company focused on the development and commercialization of advanced cell therapy products. The company's first focus of interest is in the arena of wound care. The technology employs activated white blood cells obtained from young adults healthy donor blood. The activated cells provide the natural environment for wound healing, and ensure that necessary cell activities and factor secretions are maintained as required for wound healing. This novel concept is the first of its kind in the field of wound therapy.

Stimatix GI is an early stage startup company founded in June 2009. The Company operates under the auspices of the Misgav Venture Accelerator, and is jointly funded by the Office of the Chief Scientist and the Misgav Venture Accelerator. Stimatix GI has developed the Artificial Ostomy Sphincter (AOS) product line with its AOS-1000™ and AOS-C2000™ products, unique colostomy devices that provide voluntary bowel evacuation. Aesthetically designed and easy to use, the AOS products seal the stoma and eliminate the problems inherent in wearing traditional adhesive bags. These proprietary low- profile colostomy appliances allow people with stoma to decide, at their convenience, when and where to evacuate. With the AOS products, evacuation routine is easier, quicker, and cleaner than ever. And, as the stoma is hermetically sealed, skin irritation and folliculitis are eliminated.

Avraham Pharmaceuticals Ltd. is a privately held pharmaceutical company based in Yavne, Israel, established in 2010. The company focuses on developing innovative products aimed at the treatment and prevention of neurodegenerative disorders. Its lead product candidate, Ladostigil, is designed to address mild cognitive impairment and employs multifunctional compounds that offer neuroprotective benefits. These mechanisms include the reduction of oxidative stress and microglial activation, as well as the inhibition of pro-inflammatory cytokines. Avraham Pharmaceuticals has raised $9 million to support clinical trials, including a European Phase II proof-of-concept efficacy trial targeting Alzheimer's disease.

Aposense Ltd. is a biopharmaceutical company focused on developing innovative drugs by leveraging the structural and electrical properties of biological membranes. The company specializes in creating molecular nano-motors, which are small chemical entities that harness energy from intra-membrane electric fields. Aposense's Apo-Si platform technology facilitates the delivery of genetic drugs, such as siRNA, into cells. The company's pipeline includes ATT-11T, a conjugate of its proprietary molecular nano-motor with SN-38, aimed at treating solid tumors. Additionally, Aposense is involved in clinical-stage molecular imaging and drug development, targeting apoptosis to enhance personalized patient care across various disease categories, including oncology, cardiology, and neurology. Founded in 1996 and headquartered in Petah Tikva, Israel, Aposense is dedicated to translating the science of apoptosis into effective therapies and real-time clinical imaging.

Applied Immune Technologies Ltd. is involved in the development of therapeutic molecules aimed at treating cancer, viral infections, and autoimmune diseases. The company specializes in creating T-Cell Receptor-Like (TCRL) antibodies that target intracellular-derived peptides for various therapeutic and diagnostic purposes. These TCRL antibodies have applications in pathology, as well as in vaccine design, validation, and monitoring. Additionally, they are useful in analyzing antigen presentation in various diseases. Founded in 2006 and based in Haifa, Israel, the company was previously known as BioMimic Pharma and now operates as a subsidiary of Adicet Bio, Inc.

ProtAb develops therapeutic agents that modulate cytokine regulation, tipping the balance toward anti-inflammatory signaling pathways in the treatment of autoimmune and inflammatory diseases. Its first product, Prozumab, is a monoclonal antibody with a novel mechanism of action. It is currently in late-stage preclinical development for the treatment of inflammatory bowel disease or IBD, ulcerative colitis or UC, and rheumatoid arthritis or RA. It operates as a subsidiary of Hadasit Bio-Holdings. HBL is a publicly traded subsidiary of Hadasit, the technology transfer company of the Hadassah University Hospital in Jerusalem in Israel.

Aposense Ltd. is a biopharmaceutical company focused on developing innovative drugs by leveraging the structural and electrical properties of biological membranes. The company specializes in creating molecular nano-motors, which are small chemical entities that harness energy from intra-membrane electric fields. Aposense's Apo-Si platform technology facilitates the delivery of genetic drugs, such as siRNA, into cells. The company's pipeline includes ATT-11T, a conjugate of its proprietary molecular nano-motor with SN-38, aimed at treating solid tumors. Additionally, Aposense is involved in clinical-stage molecular imaging and drug development, targeting apoptosis to enhance personalized patient care across various disease categories, including oncology, cardiology, and neurology. Founded in 1996 and headquartered in Petah Tikva, Israel, Aposense is dedicated to translating the science of apoptosis into effective therapies and real-time clinical imaging.

CollPlant Biotechnologies Ltd. is a regenerative medicine company based in Rehovot, Israel, specializing in the 3D bioprinting of tissues and organs, as well as developing tissue repair products for orthobiologics. The company utilizes a proprietary plant-based genetic engineering technology to produce recombinant type I human collagen, known as rhCollagen. Its product offerings include BioInks designed for 3D printing applications, dermal fillers for wrinkle treatment, and advanced solutions like VergenixSTR, a matrix for soft tissue repair targeting tendinopathy, and VergenixFG, which aids in the healing of acute and chronic wounds, including diabetic ulcers and burns. Founded in 2004, CollPlant aims to advance the fields of regenerative and aesthetic medicine through innovative solutions.

CollPlant Biotechnologies Ltd. is a regenerative medicine company based in Rehovot, Israel, specializing in the 3D bioprinting of tissues and organs, as well as developing tissue repair products for orthobiologics. The company utilizes a proprietary plant-based genetic engineering technology to produce recombinant type I human collagen, known as rhCollagen. Its product offerings include BioInks designed for 3D printing applications, dermal fillers for wrinkle treatment, and advanced solutions like VergenixSTR, a matrix for soft tissue repair targeting tendinopathy, and VergenixFG, which aids in the healing of acute and chronic wounds, including diabetic ulcers and burns. Founded in 2004, CollPlant aims to advance the fields of regenerative and aesthetic medicine through innovative solutions.

CollPlant Biotechnologies Ltd. is a regenerative medicine company based in Rehovot, Israel, specializing in the 3D bioprinting of tissues and organs, as well as developing tissue repair products for orthobiologics. The company utilizes a proprietary plant-based genetic engineering technology to produce recombinant type I human collagen, known as rhCollagen. Its product offerings include BioInks designed for 3D printing applications, dermal fillers for wrinkle treatment, and advanced solutions like VergenixSTR, a matrix for soft tissue repair targeting tendinopathy, and VergenixFG, which aids in the healing of acute and chronic wounds, including diabetic ulcers and burns. Founded in 2004, CollPlant aims to advance the fields of regenerative and aesthetic medicine through innovative solutions.

CollPlant Biotechnologies Ltd. is a regenerative medicine company based in Rehovot, Israel, specializing in the 3D bioprinting of tissues and organs, as well as developing tissue repair products for orthobiologics. The company utilizes a proprietary plant-based genetic engineering technology to produce recombinant type I human collagen, known as rhCollagen. Its product offerings include BioInks designed for 3D printing applications, dermal fillers for wrinkle treatment, and advanced solutions like VergenixSTR, a matrix for soft tissue repair targeting tendinopathy, and VergenixFG, which aids in the healing of acute and chronic wounds, including diabetic ulcers and burns. Founded in 2004, CollPlant aims to advance the fields of regenerative and aesthetic medicine through innovative solutions.

CritiSense, Ltd. is a medical technology company that specializes in the real-time monitoring of patients' metabolic states, particularly during surgical procedures and in intensive care units. Founded in 2004 and based in Giv'at Shmu'el, Israel, the company has developed the CritiView, a sophisticated monitoring system that provides continuous, real-time data through the assessment of four physiological parameters at the tissue level. This device enables healthcare professionals, including surgeons, anesthesiologists, and ICU caregivers, to identify imbalances in tissue and body vitality by monitoring mitochondrial function, microcirculatory blood flow, and oxygen saturation. The technology, rooted in the expertise of co-founder Professor Avraham Mayevsky, enhances surgical outcomes and patient care by facilitating informed clinical decisions based on comprehensive physiological insights.

CritiSense, Ltd. is a medical technology company that specializes in the real-time monitoring of patients' metabolic states, particularly during surgical procedures and in intensive care units. Founded in 2004 and based in Giv'at Shmu'el, Israel, the company has developed the CritiView, a sophisticated monitoring system that provides continuous, real-time data through the assessment of four physiological parameters at the tissue level. This device enables healthcare professionals, including surgeons, anesthesiologists, and ICU caregivers, to identify imbalances in tissue and body vitality by monitoring mitochondrial function, microcirculatory blood flow, and oxygen saturation. The technology, rooted in the expertise of co-founder Professor Avraham Mayevsky, enhances surgical outcomes and patient care by facilitating informed clinical decisions based on comprehensive physiological insights.