Purdue Research Foundation

Adipo Therapeutics is a biotechnology company focused on developing polymer-based nanotherapeutics aimed at treating obesity and type 2 diabetes. The company specializes in notch-inhibiting nanoparticles that are administered through weekly self-injections directly into subcutaneous white adipose tissue. These nanoparticles facilitate the conversion of energy-storing white fat into energy-burning brown fat, leading to significant metabolic changes. This process enhances energy expenditure, promotes weight loss, improves insulin sensitivity, and optimizes fat storage. By leveraging this innovative approach, Adipo Therapeutics seeks to help millions of individuals achieve natural weight loss and restore metabolic balance, ultimately transforming the management of obesity-related diseases.

OmniVis is a biotechnology company that has developed a portable pathogen detection platform aimed at improving the speed, accuracy, and affordability of pathogen testing. Its ultrasensitive handheld device provides a cost-effective alternative to traditional laboratory testing by delivering accurate results in under 30 minutes directly at the source. The platform is designed to analyze swabs or liquid samples, enabling health organizations to detect various pathogens efficiently. By utilizing single-use disposable test kits in conjunction with its handheld hardware, OmniVis allows for rapid and reliable pathogen measurement, significantly reducing the time to detection while remaining user-friendly and accessible.

Novosteo Inc. is a biotechnology company based in West Lafayette, Indiana, founded in 2017. The firm specializes in developing and manufacturing innovative drugs aimed at healing bone fractures and addressing related conditions that significantly impact patients' morbidity, mortality, and quality of life. With scientific guidance from co-founders Stewart Low and Philip Low of Purdue University, Novosteo utilizes a proprietary chemistry approach to bone targeting, which allows for the delivery of anabolic agents directly to fracture surfaces. This unique method focuses on accelerating bone regeneration and improving healing outcomes, thereby mitigating the debilitating effects associated with bone injuries and enhancing patient mobility and productivity.

ClearBlade, Inc. is an Edge Computing software company based in Austin, Texas, with an additional office in Raleigh, North Carolina. Founded in 2007, the company specializes in enabling enterprises to design and operate secure, real-time, and scalable Internet of Things (IoT) applications. ClearBlade’s platform facilitates the integration of diverse devices and systems, allowing businesses to ingest, analyze, and act on data effectively. Its offerings include a range of mobile applications, such as ClearConcert for task management and ClearQuality for testing processes, as well as solutions for strategic planning, application modernization, and data management. ClearBlade's technology is designed to run securely across various environments—cloud, on-premise, or at the edge—ensuring operational resilience and security. The company caters to multiple industries, including rail, mining, healthcare, and smart cities, helping clients leverage local computing and artificial intelligence for enhanced business outcomes.

Animated Dynamics, Inc. specializes in the development and commercialization of advanced live-tissue imaging platform technologies. Founded in 2011 and headquartered in West Lafayette, Indiana, the company employs low-coherence digital holography to facilitate the detection of cellular motions within living tissue in vitro. Its Biodynamic Imaging platform offers a comprehensive assessment of drug effects in three-dimensional tissue samples, providing critical data on cellular viability, drug mechanisms of action, and the spatial distribution of drug impacts within tumors. This innovative approach allows researchers to gain deeper insights into phenotypic responses in heterogeneous tissue environments, surpassing traditional two-dimensional screening methods. Additionally, Animated Dynamics manufactures microscopes to support its imaging capabilities.

Confluence Pharmaceuticals LLC is a biopharmaceutical company based in Indianapolis, Indiana, founded in 2010. The company specializes in developing therapeutic medications aimed at addressing social and communication impairments associated with fragile X syndrome and autism spectrum disorders. Confluence Pharmaceuticals focuses on novel drug discovery, creating treatments for these rare neurological disorders. Its innovative approach not only targets the core symptoms of autism spectrum disorders and fragile X syndrome but also extends to related conditions such as Rett syndrome and treatment-resistant anxiety, ultimately aiming to enhance the quality of life for affected individuals.

Novosteo Inc. is a biotechnology company based in West Lafayette, Indiana, founded in 2017. The firm specializes in developing and manufacturing innovative drugs aimed at healing bone fractures and addressing related conditions that significantly impact patients' morbidity, mortality, and quality of life. With scientific guidance from co-founders Stewart Low and Philip Low of Purdue University, Novosteo utilizes a proprietary chemistry approach to bone targeting, which allows for the delivery of anabolic agents directly to fracture surfaces. This unique method focuses on accelerating bone regeneration and improving healing outcomes, thereby mitigating the debilitating effects associated with bone injuries and enhancing patient mobility and productivity.

Brightlamp LLC is a computational medicine company that specializes in developing computer vision and machine learning software for medical diagnostics. Founded in 2015, the company aims to enhance medical mobility by utilizing mobile applications to diagnose symptoms. One of its key products, an application called Collide, utilizes a smart device to flash light into a subject's eye, measuring pupil dilation and constriction to help detect concussions. This innovative approach allows for the rapid assessment of eye response through the device's camera, providing valuable health insights. Brightlamp is headquartered in West Lafayette, Indiana, and is committed to transforming the way individuals engage with technology and their health.

Animated Dynamics, Inc. specializes in the development and commercialization of advanced live-tissue imaging platform technologies. Founded in 2011 and headquartered in West Lafayette, Indiana, the company employs low-coherence digital holography to facilitate the detection of cellular motions within living tissue in vitro. Its Biodynamic Imaging platform offers a comprehensive assessment of drug effects in three-dimensional tissue samples, providing critical data on cellular viability, drug mechanisms of action, and the spatial distribution of drug impacts within tumors. This innovative approach allows researchers to gain deeper insights into phenotypic responses in heterogeneous tissue environments, surpassing traditional two-dimensional screening methods. Additionally, Animated Dynamics manufactures microscopes to support its imaging capabilities.

SPEAK MODalities, LLC is a company that specializes in providing evidence-based software solutions aimed at enhancing language skills in children with autism and speech development delays. Founded in 2013 and located in West Lafayette, Indiana, the company offers a unique tablet and iPad application called SPEAKall!. This app is specifically designed with features tailored for children on the autism spectrum and those with developmental disorders, helping them to develop natural speech and language. By focusing on communication skills and language concepts, SPEAK MODalities aims to expand social horizons and engage children in culturally relevant ways.

Animated Dynamics, Inc. specializes in the development and commercialization of advanced live-tissue imaging platform technologies. Founded in 2011 and headquartered in West Lafayette, Indiana, the company employs low-coherence digital holography to facilitate the detection of cellular motions within living tissue in vitro. Its Biodynamic Imaging platform offers a comprehensive assessment of drug effects in three-dimensional tissue samples, providing critical data on cellular viability, drug mechanisms of action, and the spatial distribution of drug impacts within tumors. This innovative approach allows researchers to gain deeper insights into phenotypic responses in heterogeneous tissue environments, surpassing traditional two-dimensional screening methods. Additionally, Animated Dynamics manufactures microscopes to support its imaging capabilities.

Microfluidic Innovations LLC, established in 2009 and based in West Lafayette, Indiana, specializes in the design, development, and production of programmable lab-on-a-chip systems. The company's core product, the AssayMark System, empowers users to develop assays without the need for repeated microfluidic chip design and fabrication cycles. Their software-programmable lab-on-a-chip platform caters to drug discovery, genomics, proteomics, and cell-based research applications, serving scientists and researchers in fields such as drug discovery, clinical diagnostics, biochemistry, and cell biology.

Perfinity Biosciences, Inc. is a company focused on advancing protein sample preparation through innovative tools and technologies. Founded in 2004 and located in West Lafayette, Indiana, Perfinity offers a diverse product portfolio that includes immobilized enzymes, affinity reagents, optimized buffers, and software solutions. Key products include Soluble Smart Digest, a stable soluble trypsin for efficient digestions; Mag Beads, designed specifically for proteomics; QuicPrep, which integrates immunoaffinity and trypsin digestion in a single tube; and Flash Digest, an immobilized trypsin reactor for reproducible results. The company also provides a Workstation, a multi-column apparatus that automates protein separations and mass spectrometry sample preparation. Perfinity's solutions are tailored to enhance reproducibility and speed across a variety of workflows, including solid tissues, gels, and sample pellets. The company was previously known as QuadraSpec, Inc. before rebranding in March 2010.

Perfinity Biosciences, Inc. is a company focused on advancing protein sample preparation through innovative tools and technologies. Founded in 2004 and located in West Lafayette, Indiana, Perfinity offers a diverse product portfolio that includes immobilized enzymes, affinity reagents, optimized buffers, and software solutions. Key products include Soluble Smart Digest, a stable soluble trypsin for efficient digestions; Mag Beads, designed specifically for proteomics; QuicPrep, which integrates immunoaffinity and trypsin digestion in a single tube; and Flash Digest, an immobilized trypsin reactor for reproducible results. The company also provides a Workstation, a multi-column apparatus that automates protein separations and mass spectrometry sample preparation. Perfinity's solutions are tailored to enhance reproducibility and speed across a variety of workflows, including solid tissues, gels, and sample pellets. The company was previously known as QuadraSpec, Inc. before rebranding in March 2010.