Elevate Ventures is a not-for-profit organization based in Indiana that nurtures and develops emerging and existing high-potential businesses into high-performing Indiana-based companies. It conducts rigorous business analysis and provides robust advisory services, connecting companies with resources needed for long-term success. Beyond capital, Elevate Ventures partners with entrepreneurs, investors, and local and state organizations to address barriers such as management, business development, talent identification and retention, and technology development challenges. The organization emphasizes unbiased, in-depth perspectives and objective recommendations through a seasoned staff and external partners, supporting growth, job creation, and economic development in Indiana. It seeks ventures identifying marketplace needs and capable of transitioning from research to product development to market, aiming to sustain business success over time.

High Alpha, headquartered in Indianapolis, Indiana, operates as a B2B SaaS venture studio and early-stage investor. It conceives, launches, and scales B2B SaaS companies through High Alpha Studio, offering a blend of services including design, finance, talent, marketing, branding, and go-to-market support, alongside capital to accelerate growth toward enterprise-scale outcomes.

Allos Ventures is a venture capital firm based in Carmel, Indiana, that provides early-stage funding to business-to-business software and technology-enabled service companies in the Midwest. Founded in 2010, the firm partners with entrepreneurs to help portfolio companies accelerate growth and create value. It focuses on U.S. opportunities in software and information technology sectors and typically makes minority stake investments in Midwest-based startups.

Collina Ventures is a venture capital firm based in Carmel, Indiana. It makes minority investments in technology companies across seed, early, and later stages, with an emphasis on software and technology sectors in Central Indiana.

IU Ventures is the corporate venture capital arm of Indiana University, based in Bloomington, Indiana. It supports the university community by providing strategic investment and resources to pursue new venture opportunities, including assistance to students, faculty, staff, and alumni seeking to develop startups. The organization targets investments in business-to-business, healthcare, and technology sectors, aiming to connect aspiring ventures with university expertise and networks, and to foster entrepreneurship within the IU ecosystem.

VisionTech Partners is an angel investment group based in Indianapolis that backs early-stage and growth technology companies in Indiana and the Midwest. It focuses on sectors including life sciences, software as a service, Internet of Things, advanced materials, supply chain, and hardware. The group seeks strong management teams pursuing funding rounds of roughly $200,000 to $1 million in convertible debt or equity, with pre-money valuations under $10 million. Ideal portfolio companies are within 12 months of breakeven or have a clear plan to reach a Series A and demonstrate milestones, with an exit horizon of three to seven years. The firm emphasizes companies with novel products or services and clear competitive advantages in large markets.

Established in 1985, this organization supports early-stage commercialization and financing for innovative technologies, entrepreneurs, and companies within Virginia. It focuses on seed funding and assisting innovators to launch new businesses, create high-paying jobs, and stimulate economic growth across the state.

Heron Capital is a venture capital investment firm based in Indianapolis, Indiana, founded in 2005. The firm focuses on providing growth and late-stage funding to companies in the life sciences and healthcare sectors, including therapeutic devices, diagnostics, healthcare services, manufacturing, and related areas, with activity extending across the United States and Canada. It targets mid- and growth-stage companies and seeks investments in ventures with strong intellectual property and high-quality management. The firm is advised by a network of scientists, physicians, entrepreneurs, and leaders of national and multinational corporations to support portfolio companies.

Charmides Capital is a venture capital investment firm based in Carmel, Indiana, founded in 2015. It focuses on early-stage startups in Indiana and the Midwest, with an emphasis on B2B SaaS companies that show high growth potential. The firm co-invests with institutional investors to fund these ventures and provides strategic value through a diverse group of partners. Inspired by the virtue sophrosyne, the firm aims for disciplined, responsible actions in supporting portfolio companies.

Flywheel Fund is a Bloomington, Indiana-based venture capital firm founded in 2020 that invests in early-stage technology startups, with a focus on Indiana-based companies. It backs ventures across life sciences, medical devices, and software-enabled technology, reflecting an emphasis on high-potential startups at the intersection of software and hardware.

Gravity Ventures is a venture capital investment firm based in Indianapolis, Indiana. Founded in 2008, it focuses on early-stage technology and tech-enabled startups, investing across a range of industries and providing capital and strategic support to help startups scale.

OneCause is a nonprofit fundraising technology company that provides online and event fundraising software to help nonprofits raise more money and improve the giving experience. The platform supports mobile bidding, online fundraising, peer-to-peer campaigns, event management, payment processing, online ticketing, mobile donations, text-to-give, and registration and checkout. Based in Indianapolis, OneCause has been recognized on the Inc. 500 list of Fastest Growing Companies and received a Techpoint MIRA award for Mobile Technology Excellence and Innovation.

HG Ventures is the venture capital arm of The Heritage Group. It invests in early and growth-stage companies developing advanced materials and systems for transportation infrastructure, environmental services, and specialty chemicals, as well as digital systems relevant to these industries. The firm aims to partner with portfolio companies by leveraging The Heritage Group’s operating companies and research center to provide technical expertise, manufacturing capabilities, and expansive industry networks. HG Ventures focuses on opportunities in the United States, typically backing companies positioned to improve infrastructure resilience, environmental performance, and energy production through innovative materials and processes. Through its strategic support, the firm helps portfolio companies scale and integrate with real-world supply chains and customers.

Spring Mill Venture Partners is a venture capital firm that funds seed and early-stage information technology and life sciences companies in Indiana and the broader Midwest. The firm provides capital and strategic and tactical support to help high-growth startups grow and prosper, focusing on information technology, healthcare technology, and life sciences sectors. Founded in 2004 and based in Carmel, Indiana, it targets companies in Indiana, Illinois, Kentucky, Michigan, and Ohio.

Boomerang Ventures is a venture capital firm based in Indianapolis, Indiana, founded in 2019, focusing on building commercially successful companies in the future of healthcare, including connected medical devices, digital health, tech-enabled health services, and healthcare informatics.

Founded in 2011, Hyde Park Venture Partners is a Chicago-based venture capital firm specializing in early-stage investments. It focuses on high-growth technology startups across the Midwest, with an emphasis on software and tech-enabled businesses. The firm typically invests between $0.1 million to $2.5 million, co-investing with Hyde Park Angels. They actively mentor portfolio companies, supporting product development, business strategy, financing, and exit strategies.

Capital Midwest Fund is a venture capital firm based in Mequon, Wisconsin, that backs early-stage companies in the Midwest across sectors such as advanced manufacturing, life sciences, healthcare, B2B and business services, software and SaaS, information technology and IoT, and energy. The firm concentrates on Midwest investments, with Wisconsin as a primary focus, and targets initial investments typically in the low to mid single-digit millions per company. It also pursues ESG and diversity-inclusion related investments as part of its strategy.

M25 is a Chicago-based venture capital firm established in 2015 by Victor Gutwein and Mike Asem, focused on funding pre-seed and seed-stage technology startups in the Midwest. The firm supports portfolio companies across multiple industries, with a regional footprint spanning 24 Midwest cities in 11 states. Since its inception, M25 has backed more than 90 early-stage tech startups, aiming to accelerate growth and strengthen the Midwest startup ecosystem.

Health Cloud Capital is a growth investment firm based in Indianapolis that focuses on healthcare IT and cloud-enabled healthcare software. Founded in 2017, it pursues growth opportunities in cloud-based healthcare SaaS companies with strong recurring revenue, typically seeking at least $5 million in annual recurring revenue, and aims to improve healthcare outcomes through data-driven approaches. The firm leverages expertise in healthcare, diagnostics, and information technology to partner with portfolio companies, supporting scaling and operational growth in the cloud, software-as-a-service, and digital health segments.

Sixty8 Capital is a seed-stage venture capital firm based in Indianapolis, Indiana. Founded in 2019 by Kelli Jones and Paul Ehlinger, it focuses on early-stage investments in technology, tech-enabled products, and direct-to-consumer startups. The firm emphasizes backing diverse founders, with a focus on Black, Brown, women, and LGBTQ+-led ventures. It is backed by Allos Ventures, leveraging extensive venture capital experience.

Roll Tack Ventures is a venture capital investment firm founded in 2024 and based in Indianapolis, Indiana. It invests in midmarket technology companies with a Midwest presence and collaborates with technology entrepreneurs to address pressing issues.

Mission Innovation Network is a network-based venture capital firm founded in 2020 and based in South Bend, Indiana. It supports mission-driven, local companies by investing in early-stage ventures across sectors including consumer health and wellness, ESG fintech, jobs and education, sustainability, consumer basic needs, social media, and community collaboration, with a focus on empowering local communities.

Lightship Capital is a venture capital firm based in Cincinnati, Ohio, with an additional presence in Indianapolis. It concentrates on seed to Series A investments in Midwest startups spanning artificial intelligence, consumer packaged goods, health tech and healthcare, e-commerce, sustainability, and related sectors. The firm prioritizes funding for ventures led by underrepresented founders, including BIPOC individuals, women, LGBTQ+ people, and people with disabilities, aiming to expand access to venture capital beyond traditional hubs. By focusing on the Midwest and regional economic growth, Lightship Capital seeks companies with strong growth potential that advance local communities while delivering meaningful returns for its investors.

Lumina Impact Ventures is the corporate venture arm of Lumina Foundation and makes impact investments in education technology. It extends the foundation’s work beyond grant funding by engaging the private sector to generate ideas, build knowledge, and attract new capital to expand learning opportunities. The arm supports entrepreneurs of color and founders from low-income backgrounds and fosters a collaborative, founder-friendly ecosystem. By leveraging Lumina’s networks, it connects portfolio companies with trusted advisors and other non-financial resources that can accelerate growth. It primarily invests in early-stage companies developing innovative technologies and tech-enabled platforms that create opportunities for people to learn after high school.

Eli Lilly and Company is a global pharmaceutical leader engaged in the discovery, development, manufacture, and sale of medicines. It operates facilities in the United States, Puerto Rico, and many other countries, with products sold in about 135 countries. The company focuses on therapies in neuroscience, cardiometabolic, cancer, and immunology, and also conducts research in animal health and animal agriculture. Lilly supports patient outcomes and education through a philanthropic foundation that funds programs in underserved communities, including STEM education in Indianapolis.

Pearl Street Venture Funds is a venture capital firm based in Indianapolis, Indiana, investing in early-stage life sciences companies, including biotech, pharmaceutical, medical device, and agri-bio ventures, and backing therapeutic products that leverage next-generation technologies. The firm can serve as a lead or co-investor and seeks opportunities primarily in Indiana, with additional offices in Los Angeles, West Lafayette, San Diego, and Gaithersburg.

Mutual Capital Partners is a Westlake, Ohio-based venture capital firm founded in 2004 that concentrates on early-stage investments in healthcare information technology, medical devices, and software companies in the United States. The firm emphasizes active management and collaborates with investors to support due diligence, facilitate customer introductions for portfolio companies, and provide ongoing guidance to portfolio executives, with a focus on building strong management teams and helping portfolio companies scale.

IrishAngels is an angel group and early-stage venture firm based in Chicago, Illinois, founded in 2012. It funds pre-seed and seed startups across the United States and leverages an active network to help portfolio companies grow. Its investment focus includes software and technology-enabled sectors such as B2B SaaS, consumer products, and medical technology, with interests extending to artificial intelligence and machine learning, fintech, e-commerce, health tech, edtech, IoT, mobility, cleantech, climate tech, real estate tech, and related areas.

SOSV is a global venture capital firm that supports early-stage startups through active, founder-first development programs. Its flagship initiatives HAX and IndieBio provide facilities, engineering resources, services, and laboratory equipment to accelerate product development and prepare companies for subsequent funding rounds. SOSV focuses on deep technology across health, environmental, and cross-border software sectors, aiming to solve human and planetary health challenges. In addition to providing capital, the firm emphasizes intensive programmatic support to help portfolio companies move quickly from seed toward growth, including customer acquisition and scale. The firm operates globally with a bias toward startups targeting rapid international expansion, especially in Asia, and tends to back a small cohort of high-potential companies to accelerate their progress and attract leading investors.

Cultivation Capital is a St. Louis, Missouri-based venture capital firm that backs seed- to Series B–stage companies in the United States. Its focus includes life sciences, healthcare, agriculture technology, and related software, information technology, and geospatial sectors, with investments spanning early rounds to support product development and market entry.

RA Capital Management is a Boston-based investment firm that specializes in life sciences and healthcare companies. The firm provides investment management and venture capital services, backing companies developing drugs, medical devices, diagnostics, and biotech tools. Its team combines expertise in biology, chemistry, and medicine with industry and business development experience. RA Capital supports companies across multiple stages, from seed funding to growth financings, including private and public rounds, and often takes board seats and seeks co-investment opportunities. Through its activity, it aims to identify technologies with potential to advance prevention and treatment, genetic testing and personalized medicine, and other patient-focused innovations.

New Enterprise Associates is a U.S.-based venture capital firm founded in 1977 and headquartered in Menlo Park, California. It invests in technology and healthcare companies across stages and geographies, supporting startups from seed to growth. The firm operates globally with investments in the United States, Asia, and Brazil among others, and has a long track record of portfolio IPOs and acquisitions. It has over $19 billion in cumulative committed capital.

Founded in 1989, OrbiMed is a New York-based healthcare-dedicated investment firm managing approximately $5 billion in assets. It invests across the spectrum of healthcare companies, from private start-ups to large multinational corporations, focusing on biopharmaceuticals, life sciences, digital health, medical devices, and diagnostics sectors globally.

Plymouth Growth is a Michigan-based investment firm focused on growth-stage technology companies, primarily in B2B software and tech-enabled services in the United States and Canada. Based in Ann Arbor, the firm targets mid-continent opportunities and emphasizes partnering with entrepreneurs with proven business models and strong teams. It prioritizes people and culture alongside metrics, leveraging operational and advisory experience to support scalable growth. Plymouth Growth manages multiple growth funds and seeks to help portfolio companies accelerate expansion through strategic guidance and capital.

XSeed Capital is a Portola Valley, California-based venture capital firm that makes early-stage technology investments in the United States. Founded in 2006, it targets software, information technology, and related technology sectors and often provides seed funding with follow-on capital through multiple rounds. The firm seeks differentiated portfolio companies that deliver unique customer value and works to help entrepreneurs build value, reach risk-reduction milestones, and progress toward subsequent value inflection points.

Sequoia Capital is a venture capital firm founded in 1972 and based in Menlo Park, California. It pursues investments across multiple sectors, including information technology, healthcare, manufacturing, mobile, nanotechnology, financial services, internet, energy, media, and retail, and provides early to growth-stage funding coupled with strategic support to help founders build lasting, category-defining companies.

Chicago Ventures is a Chicago-based venture capital firm focused on seed- and early-stage technology companies in the Midwest. Founded in 2011, it backs startups across software, supply chain and logistics, fintech, healthcare, consumer media, data management, proptech, mobility, and enterprise tools, with initial investments typically USD 0.25 million to USD 1 million. The firm partners with entrepreneurs to build enduring companies in undercapitalized ecosystems and is registered as an investment adviser (RIA).

Revolution is a Washington, D.C.-based investment firm founded in 2005 by Steve Case. It partners with entrepreneurs to build technology-enabled businesses, investing across stages from early-stage to growth, with a focus on innovating traditional industries. The firm operates a family of funds, including Revolution Ventures and Revolution Growth, and emphasizes geographic diversification via initiatives such as Rise of the Rest Seed Funds to support startups in high-potential regions. Its teams pursue opportunities in consumer internet, media and entertainment, software and services, healthcare IT, financial services, energy, and other technology-enabled sectors across the United States. The firm frequently leads early rounds and may take board seats to help portfolio companies scale.

The LegalTech Fund is a venture capital firm that backs companies transforming the legal industry through technology. It focuses on legal tech ventures that improve the delivery of legal services and access to justice, supporting early- and growth-stage startups at the intersection of law and technology.

Ceres Venture Fund is a Midwest-focused venture capital firm based in Illinois that concentrates on early-stage investments in high-growth companies. It targets opportunities in healthcare, information technology, and business services, and seeks to partner with proven entrepreneurs, providing them with resources and strategic support to accelerate growth and scale their businesses.

Ludlow Ventures is a Michigan-based venture capital firm founded in 2009 that focuses on seed and early-stage technology companies in the United States, with offices in Detroit and Southfield. The firm backs software and information technology startups and emphasizes a pragmatic, founder-friendly approach, offering hands-on support, product testing, and access to its network to help portfolio companies grow. It advocates a low-ego, straightforward culture and aims to deliver practical, no-nonsense value rather than traditional venture capital puffery.

Annox Capital is a venture capital and private equity firm founded in 2013 and based in Birmingham, Michigan. It provides growth capital for startups and late-stage companies, with a focus on manufacturing, logistics, banking, healthcare, and real estate. The firm seeks investments in enterprises that employ disruptive technology or online strategies to improve business processes or human experiences, typically pursuing deals ranging from $100,000 to $30 million.

OCA Ventures is a Chicago-based venture capital firm founded in 1999 that makes early-stage equity investments in technology-driven companies in the United States and Canada. The firm concentrates on software and information technology-enabled businesses, including consumer software, enterprise software, fintech, and digital health, with a preference for companies demonstrating dramatic growth potential and scalable models. By backing startups at seed to early-growth stages, OCA Ventures aims to support firms developing innovative software solutions and technology-enabled services across industries, including healthcare technology systems and financial services. The team seeks partnerships with entrepreneurs building scalable platforms and differentiated products, leveraging its regional presence and sector focus to add operational and strategic value.

MassVentures is a Massachusetts-based venture capital firm that provides seed and early-stage funding to high-growth startups in the Massachusetts innovation economy, helping concepts move from idea to commercialization. Founded in 1978 as a quasi-public corporation by the Legislature of the Commonwealth, it is governed by an independent board and managed by experienced venture investors. The firm focuses on information technology, healthcare, cybersecurity, e-commerce, mobile, manufacturing, and robotics sectors in Massachusetts and operates accelerator programs to support portfolio companies. MassVentures leverages the state's entrepreneurial ecosystem, educated workforce, and centers of innovation to back early-stage ventures.

Serra Ventures is a venture capital firm based in Champaign, Illinois, that invests in technology companies across the United States and select international locations. The firm concentrates on early-stage and growth opportunities in information technology, deep technology, instrumentation, software as a service, devices, B2B, and agricultural technologies, with a focus on the Midwest and West Coast regions. Serra Ventures supports portfolio companies through strategic guidance, networks, and resources to help scale technology-enabled businesses.

Redpoint Ventures is an independent venture capital firm founded in 1999. It backs startups across seed, early, and growth stages and manages funds totaling about $4 billion. Headquartered in California, United States, Redpoint focuses on technology-driven opportunities in software, internet, enterprise IT, AI, cybersecurity, big data, fintech, healthcare, and related areas, with a global footprint that includes Redpoint China Ventures for early-stage investments in China. The firm partners with founders to create new markets and redefine existing ones, offering strategic guidance and capital to help portfolio companies scale.

Norwest Venture Partners is a global technology venture capital and growth equity firm founded in 1961 and based in California. The firm backs seed through growth-stage companies across the United States, India and Israel, with investments spanning technology, cloud and IT infrastructure, Internet and consumer products, SaaS, business services, financial services, healthcare, and other sectors. It has funded hundreds of companies and leverages a broad network and operating experience to help founders scale their businesses. Norwest pursues a flexible, long-term approach, tailoring its capital and support to each stage and company, and it deploys capital across multiple rounds from early checks to growth investments. The firm is known for partnering with CEOs and management teams to accelerate growth through strategic guidance, operational resources, and access to its portfolio network.

Connetic Ventures is a venture capital firm based in Covington, Kentucky. Established in the mid-2010s, it provides capital and strategic support to early-stage startups, often partnering with other venture capital firms and angel syndicates for seed investments. The firm targets software, data, fintech, and consumer sectors across North America, including the United States and Canada.

MK Capital is a United States-based venture capital and private equity firm founded in 2003. It concentrates on early and growth-stage technology companies, focusing on software and other technology-enabled sectors and primarily targets opportunities in the U.S. market. The firm provides strategic capital, deep operating expertise, and hands-on collaboration, including active board participation to help portfolio companies scale. MK Capital operates from multiple offices in the Chicago area and on the West Coast, including Northbrook, Deerfield, Ann Arbor, and Santa Monica, reflecting a broad regional footprint. By partnering with management teams on strategy, operations, and technology, the firm aims to accelerate growth for disruptive B2B software and related technology businesses.

Bessemer Venture Partners is a long-established venture capital firm based in Redwood City, California, founded in 1911. The firm makes early-stage and growth investments across software, cloud, fintech, cybersecurity, artificial intelligence, biotech, healthcare, consumer services, marketplaces and other technology sectors, with global reach in the United States, Israel, Canada and India. It supports founders from seed to scale, providing strategic guidance and capital to build durable businesses. The firm has backed notable companies such as Pinterest, LinkedIn, Shopify, Yelp, Twilio, DocuSign and Wix, among others, reflecting a history of funding transformative technology companies. Bessemer Venture Partners operates as a registered investment adviser and pursues opportunities across information technology, hardware and services worldwide.