Elevate Ventures is a not-for-profit organization based in Indiana that nurtures and develops emerging and existing high-potential businesses into high-performing Indiana-based companies. It conducts rigorous business analysis and provides robust advisory services, connecting companies with resources needed for long-term success. Beyond capital, Elevate Ventures partners with entrepreneurs, investors, and local and state organizations to address barriers such as management, business development, talent identification and retention, and technology development challenges. The organization emphasizes unbiased, in-depth perspectives and objective recommendations through a seasoned staff and external partners, supporting growth, job creation, and economic development in Indiana. It seeks ventures identifying marketplace needs and capable of transitioning from research to product development to market, aiming to sustain business success over time.

High Alpha, headquartered in Indianapolis, Indiana, operates as a B2B SaaS venture studio and early-stage investor. It conceives, launches, and scales B2B SaaS companies through High Alpha Studio, offering a blend of services including design, finance, talent, marketing, branding, and go-to-market support, alongside capital to accelerate growth toward enterprise-scale outcomes.

Allos Ventures is a venture capital firm based in Carmel, Indiana, that provides early-stage funding to business-to-business software and technology-enabled service companies in the Midwest. Founded in 2010, the firm partners with entrepreneurs to help portfolio companies accelerate growth and create value. It focuses on U.S. opportunities in software and information technology sectors and typically makes minority stake investments in Midwest-based startups.

Collina Ventures is a venture capital firm based in Carmel, Indiana, United States, that makes minority investments across seed, early, and later stages in software and technology companies with a focus on Central Indiana.

IU Ventures, established in Bloomington, Indiana since 1997, supports Indiana University students, faculty, staff, and alumni in exploring new venture opportunities. It focuses on investments in B2B, healthcare, and technology sectors.

VisionTech Angels, founded in 2009 and based in Indianapolis, Indiana, is an angel investment group that focuses on early-stage technology companies with innovative products and services. The firm targets high-potential businesses operating in various sectors, including life sciences, software as a service (SaaS), Internet of Things (IoT), advanced materials, supply chain, and hardware. VisionTech Angels seeks to invest between $200,000 and $1 million in companies with a pre-money valuation under $10 million. The ideal candidates are those within 12 months of reaching breakeven or that have identified their next round of financing, demonstrating progress towards key milestones. The firm aims for exits within a timeframe of three to seven years, emphasizing investments in firms with strong management teams and clear competitive advantages in large markets.

Established in 1985, this organization supports early-stage commercialization and financing for innovative technologies, entrepreneurs, and companies within Virginia. It focuses on seed funding and assisting innovators to launch new businesses, create high-paying jobs, and stimulate economic growth across the state.

Heron Capital is a venture capital investment firm based in Indianapolis, Indiana, founded in 2005. The firm focuses on providing growth and late-stage funding to companies in the life sciences and healthcare sectors, including therapeutic devices, diagnostics, healthcare services, manufacturing, and related areas, with activity extending across the United States and Canada. It targets mid- and growth-stage companies and seeks investments in ventures with strong intellectual property and high-quality management. The firm is advised by a network of scientists, physicians, entrepreneurs, and leaders of national and multinational corporations to support portfolio companies.

Charmides Capital is a venture capital investment firm based in Carmel, Indiana, founded in 2015. It focuses on early-stage startups in Indiana and the Midwest, with an emphasis on B2B SaaS companies that show high growth potential. The firm co-invests with institutional investors to fund these ventures and provides strategic value through a diverse group of partners. Inspired by the virtue sophrosyne, the firm aims for disciplined, responsible actions in supporting portfolio companies.

Flywheel Fund is a venture capital firm based in Bloomington, Indiana. Founded in 2020, it invests in Indiana-based early-stage technology startups, with a focus on life sciences, medical devices, and software-enabled technologies.

Gravity Ventures is a venture capital firm based in Indianapolis, Indiana, founded in 2008. It specializes in investing in early-stage technology and tech-enabled companies across various industries, providing seed and early-stage capital to startups with a focus on software and related tech sectors.

OneCause is a nonprofit fundraising technology company that provides online and event fundraising software to help nonprofits raise more money and improve the giving experience. The platform supports mobile bidding, online fundraising, peer-to-peer campaigns, event management, payment processing, online ticketing, mobile donations, text-to-give, and registration and checkout. Based in Indianapolis, OneCause has been recognized on the Inc. 500 list of Fastest Growing Companies and received a Techpoint MIRA award for Mobile Technology Excellence and Innovation.

HG Ventures is the venture capital arm of The Heritage Group. It invests in early and growth-stage companies developing advanced materials and systems for transportation infrastructure, environmental services, and specialty chemicals, as well as digital systems relevant to these industries. The firm aims to partner with portfolio companies by leveraging The Heritage Group’s operating companies and research center to provide technical expertise, manufacturing capabilities, and expansive industry networks. HG Ventures focuses on opportunities in the United States, typically backing companies positioned to improve infrastructure resilience, environmental performance, and energy production through innovative materials and processes. Through its strategic support, the firm helps portfolio companies scale and integrate with real-world supply chains and customers.

Spring Mill Venture Partners is a venture capital firm based in Carmel, Indiana, established in 2004. The firm specializes in seed and early-stage investments, primarily targeting high-growth companies within the information technology, healthcare technology, and life sciences sectors. Its investment focus is on businesses located in Indiana and the surrounding Midwest region, which includes Illinois, Kentucky, Michigan, and Ohio. Spring Mill Venture Partners aims to provide both capital and strategic support to help early-stage companies achieve sustainable growth and success.

Founded in 2019, Boomerang Ventures is a venture capital firm based in Indianapolis, Indiana. It focuses on building commercially successful companies in the future of healthcare, with an emphasis on connected medical devices, digital health, tech-enabled health services, and healthcare informatics.

Founded in 2011, Hyde Park Venture Partners is a Chicago-based venture capital firm specializing in early-stage investments. It focuses on high-growth technology startups across the Midwest, with an emphasis on software and tech-enabled businesses. The firm typically invests between $0.1 million to $2.5 million, co-investing with Hyde Park Angels. They actively mentor portfolio companies, supporting product development, business strategy, financing, and exit strategies.

Capital Midwest Fund is a venture capital firm based in Mequon, Wisconsin. It specializes in early-stage investments across various sectors including life sciences, information technology, advanced manufacturing, B2B, and healthcare, with a focus on companies located in the Midwest region of the United States.

M25 is a Chicago-based venture capital firm established in 2015 by Victor Gutwein and Mike Asem, focused on funding pre-seed and seed-stage technology startups in the Midwest. The firm supports portfolio companies across multiple industries, with a regional footprint spanning 24 Midwest cities in 11 states. Since its inception, M25 has backed more than 90 early-stage tech startups, aiming to accelerate growth and strengthen the Midwest startup ecosystem.

Health Cloud Capital is a growth investment firm based in Indianapolis that focuses on healthcare IT and cloud-enabled healthcare software. Founded in 2017, it pursues growth opportunities in cloud-based healthcare SaaS companies with strong recurring revenue, typically seeking at least $5 million in annual recurring revenue, and aims to improve healthcare outcomes through data-driven approaches. The firm leverages expertise in healthcare, diagnostics, and information technology to partner with portfolio companies, supporting scaling and operational growth in the cloud, software-as-a-service, and digital health segments.

Sixty8 Capital is a seed-stage venture capital firm based in Indianapolis, Indiana, founded in 2019 by Kelli Jones and Paul Ehlinger. The firm specializes in investing in technology, tech-enabled, and direct-to-consumer startups, with a particular emphasis on supporting entrepreneurs from diverse communities, including Black, Brown, women, and LGBTQ+ founders. Sixty8 Capital is backed by Allos Ventures, which brings 45 years of venture capital experience to the firm, enhancing its commitment to fostering innovation and inclusivity in the startup ecosystem.

Roll Tack Ventures is a venture capital investment firm founded in 2024 and based in Indianapolis, Indiana. It invests in midmarket technology companies with a Midwest presence and collaborates with technology entrepreneurs to address pressing issues.

Mission Innovation Network is a venture capital firm established in 2020 and located in South Bend, Indiana. The firm is dedicated to supporting mission-driven companies that focus on empowering local communities. It targets early-stage investments in a variety of sectors, including consumer health and wellness, fintech with an emphasis on environmental, social, and governance (ESG) criteria, jobs and education, sustainability, basic consumer needs, social media, and community collaboration. By fostering innovation in these areas, Mission Innovation Network aims to contribute positively to community development and enhance the quality of life for local residents.

Lightship Capital is a venture capital firm focused on investing in early-stage startups, particularly those led by underrepresented minorities and located outside of major tech hubs like Silicon Valley, New York City, and Boston. The company concentrates its investments in sectors such as artificial intelligence, consumer packaged goods, sustainability, e-commerce, healthcare, and real estate.

Lumina Impact Ventures is the corporate venture arm of Lumina Foundation that makes impact investments in education technology. It funds emerging companies that align with Lumina Foundation's mission to expand access to learning beyond high school. Through its investments, it engages the private sector to generate ideas, build knowledge, and attract capital, while supporting entrepreneurs, particularly those from underrepresented groups, by leveraging Lumina's networks to connect portfolio companies with advisors and non-financial resources. The focus is on technology and tech-enabled platforms that create opportunities for lifelong learning and improved outcomes in education.

Eli Lilly and Company is a global pharmaceutical leader engaged in the discovery, development, manufacture, and sale of medicines. It operates facilities in the United States, Puerto Rico, and many other countries, with products sold in about 135 countries. The company focuses on therapies in neuroscience, cardiometabolic, cancer, and immunology, and also conducts research in animal health and animal agriculture. Lilly supports patient outcomes and education through a philanthropic foundation that funds programs in underserved communities, including STEM education in Indianapolis.

Pearl Street Venture Funds, established in 2003, is a venture capital firm focused on investing in early-stage life sciences companies. It specializes in biotech, pharmaceuticals, medical devices, and agri-bio sectors, with a preference for Indiana-based companies. The firm can act as both lead and co-investor.

Mutual Capital Partners, established in 2004, is a private equity firm headquartered in Westlake, Ohio. The company specializes in venture capital investments, focusing on medical device and healthcare IT companies across the United States. It typically leads or co-leads investments, providing not only capital but also strategic guidance and operational support to its portfolio companies. The firm works closely with its network of over 100 investors, leveraging their expertise for due diligence, customer introductions, and ongoing executive counsel.

IrishAngels is an angel group and early-stage venture firm based in Chicago, Illinois, founded in 2012. It funds pre-seed and seed startups across the United States and leverages an active network to help portfolio companies grow. Its investment focus includes software and technology-enabled sectors such as B2B SaaS, consumer products, and medical technology, with interests extending to artificial intelligence and machine learning, fintech, e-commerce, health tech, edtech, IoT, mobility, cleantech, climate tech, real estate tech, and related areas.

SOSV is a global venture capital firm that supports early-stage startups through active, founder-first development programs. Its flagship initiatives HAX and IndieBio provide facilities, engineering resources, services, and laboratory equipment to accelerate product development and prepare companies for subsequent funding rounds. SOSV focuses on deep technology across health, environmental, and cross-border software sectors, aiming to solve human and planetary health challenges. In addition to providing capital, the firm emphasizes intensive programmatic support to help portfolio companies move quickly from seed toward growth, including customer acquisition and scale. The firm operates globally with a bias toward startups targeting rapid international expansion, especially in Asia, and tends to back a small cohort of high-potential companies to accelerate their progress and attract leading investors.

Founded in 2012, Cultivation Capital is a venture capital firm based in Saint Louis, Missouri. The firm focuses on early-stage investing in life sciences, health technology, software, IT, agriculture tech, and geospatial tech sectors.

RA Capital Management is a Boston-based investment firm focused on life sciences and healthcare. It provides venture and growth capital to public and private companies developing drugs, medical devices, diagnostics, and biotech tools, investing across stages from seed to IPO and follow-on financings. The firm often co-invests and takes board seats, pursuing opportunities in genetics, personalized medicine, cost-effective diagnostics, and nurse-enabled technologies. Its team combines expertise in biology, chemistry, and medicine with industry and business development experience. Founded in the early 2000s, RA Capital Management operates as an investment firm serving life sciences companies in the United States and Europe.

New Enterprise Associates is a U.S.-based venture capital firm founded in 1977 and headquartered in Menlo Park, California. It invests in technology and healthcare companies across stages and geographies, supporting startups from seed to growth. The firm operates globally with investments in the United States, Asia, and Brazil among others, and has a long track record of portfolio IPOs and acquisitions. It has over $19 billion in cumulative committed capital.

Founded in 1989, OrbiMed is a New York-based healthcare-dedicated investment firm managing approximately $5 billion in assets. It invests across the spectrum of healthcare companies, from private start-ups to large multinational corporations, focusing on biopharmaceuticals, life sciences, digital health, medical devices, and diagnostics sectors globally.

Plymouth Growth is a Michigan-based investment firm focused on growth-stage technology companies, primarily in B2B software and tech-enabled services in the United States and Canada. Based in Ann Arbor, the firm targets mid-continent opportunities and emphasizes partnering with entrepreneurs with proven business models and strong teams. It prioritizes people and culture alongside metrics, leveraging operational and advisory experience to support scalable growth. Plymouth Growth manages multiple growth funds and seeks to help portfolio companies accelerate expansion through strategic guidance and capital.

XSeed Capital is a venture capital firm based in Portola Valley, California, that targets early-stage technology companies across the United States. It specializes in software, computer science and information technology sectors, making seed investments and providing follow-on capital through multiple rounds. The firm actively supports its portfolio companies to build value, achieve risk-reduction milestones, and reach strategic value inflection points, helping entrepreneurs advance from inception to growth.

Sequoia Capital is a venture capital firm founded in 1972 and based in Menlo Park, California. It pursues investments across multiple sectors, including information technology, healthcare, manufacturing, mobile, nanotechnology, financial services, internet, energy, media, and retail, and provides early to growth-stage funding coupled with strategic support to help founders build lasting, category-defining companies.

Founded in 2012, Chicago Ventures is a venture capital firm based in Chicago, Illinois. It partners closely with exceptional entrepreneurs building companies in undercapitalized high-potential ecosystems, focusing on seed-stage investments in healthcare, business services, and technology-facing companies across the Midwest.

Revolution is a Washington, D.C.-based investment firm founded in 2005 by Steve Case, with additional offices in San Francisco. It operates a family of funds including Revolution Ventures and Revolution Growth, focusing on venture capital and growth investments in technology-enabled companies that disrupt traditional industries. The firm backs startups and growth-stage companies across sectors such as consumer internet, software, media, financial services, health, energy, and education, often investing alongside other top-tier investors and taking board seats when appropriate. It emphasizes entrepreneurship and geographic diversity, supporting companies in high-potential geographies through initiatives like Rise of the Rest Seed Funds. Revolution seeks opportunities across multiple stages, aiming to partner with capable founders and help scale companies from early ideas to growth, while maintaining a focus on driving meaningful change across industries.

The LegalTech Fund is a venture capital firm based in the United States that focuses on investing in companies innovating within the legal industry. Established in 2022, it targets a diverse range of sectors, including information technology, financial services, consumer products and services, and business products and services. The firm aims to support the growth of legal technology and related fields by investing up to one million dollars in promising ventures. Its investment strategy encompasses both North America and Europe, reflecting a commitment to fostering advancements that can transform the practice of law. The LegalTech Fund seeks to empower startups and established companies that are reshaping the legal landscape through technological innovation.

Ceres Venture Fund is a Chicago-based venture capital firm established in 2005, focused on investing in early-stage, high-growth companies located in the Midwest. The fund aims to partner with proven entrepreneurs and provide them with the necessary resources to drive their success. Ceres Venture Fund primarily invests in sectors such as healthcare, information technology, and business services, reflecting its commitment to fostering innovation and growth within the region. By concentrating on the Midwest, Ceres Venture Fund seeks to bolster the local economy and support the development of promising businesses.

Founded in 2013, Annox Capital is a venture capital firm based in Birmingham, Michigan. It invests in companies that employ disruptive technology or online strategies to significantly improve business processes or human experiences across various sectors such as manufacturing, logistics, banking, healthcare, and real estate.

Founded in 2009, Ludlow Ventures is a Michigan-based venture capital firm specializing in early-stage investments. It focuses on technology companies across the United States, typically investing between $25,000 and $150,000 per company. Known for its straightforward approach, it aims to build trust and friendship with invested teams.

Founded in 1999, OCA Ventures is a Chicago-based venture capital firm focusing on early-stage investments primarily in technology and highly-scalable services businesses. The firm's investment focus areas include digital health, fintech, consumer software, and enterprise software.

MassVentures is a Massachusetts-based venture capital firm that provides seed and early-stage funding to high-growth startups in the Massachusetts innovation economy, helping concepts move from idea to commercialization. Founded in 1978 as a quasi-public corporation by the Legislature of the Commonwealth, it is governed by an independent board and managed by experienced venture investors. The firm focuses on information technology, healthcare, cybersecurity, e-commerce, mobile, manufacturing, and robotics sectors in Massachusetts and operates accelerator programs to support portfolio companies. MassVentures leverages the state's entrepreneurial ecosystem, educated workforce, and centers of innovation to back early-stage ventures.

Serra Ventures is a venture capital firm based in Champaign, Illinois, that invests in technology companies across the United States and select international locations. The firm concentrates on early-stage and growth opportunities in information technology, deep technology, instrumentation, software as a service, devices, B2B, and agricultural technologies, with a focus on the Midwest and West Coast regions. Serra Ventures supports portfolio companies through strategic guidance, networks, and resources to help scale technology-enabled businesses.

Redpoint Ventures is an independent venture capital firm founded in 1999. It backs startups across seed, early, and growth stages and manages funds totaling about $4 billion. Headquartered in California, United States, Redpoint focuses on technology-driven opportunities in software, internet, enterprise IT, AI, cybersecurity, big data, fintech, healthcare, and related areas, with a global footprint that includes Redpoint China Ventures for early-stage investments in China. The firm partners with founders to create new markets and redefine existing ones, offering strategic guidance and capital to help portfolio companies scale.

Norwest Venture Partners is a venture capital and growth equity firm founded in 1961 and headquartered in California, with a presence in Menlo Park and Palo Alto. It backs technology-driven companies across stages, from seed to growth, primarily in the United States, with extensions into India and Israel. The firm invests in sectors including software, information services, business services, financial services, healthcare, enterprise technology, and consumer products and services. Norwest emphasizes a proactive, partnership-based approach, leveraging its extensive network, operating experience, and a broad range of resources to help CEOs and founders scale their businesses. Across its portfolio, Norwest has supported hundreds of companies through multiple rounds of financing, aiming to partner with teams that demonstrate strong market position, revenue traction, and durable growth potential. The firm seeks to combine capital with strategic guidance, enabling portfolio companies to accelerate product development, go-to-market execution, and international expansion where appropriate.

Connetic Ventures is a venture capital firm based in Covington, Kentucky. Established in the mid-2010s, it provides capital and strategic support to early-stage startups, often partnering with other venture capital firms and angel syndicates for seed investments. The firm targets software, data, fintech, and consumer sectors across North America, including the United States and Canada.

MK Capital is a Chicago-area venture capital and private equity firm that invests in emerging technology companies across the early and growth stages in the United States. Founded in 2003, the firm focuses on software and technology-enabled businesses, including digital software, digital media, data center automation, technology-enabled business services, and education technology. It provides multi-stage capital and leverages deep operating experience to help portfolio companies scale, with active board involvement and collaborative support on strategy, operations and technology. The firm maintains offices in Northbrook, Illinois; Ann Arbor, Michigan; and Santa Monica, California, and manages over $500 million in assets.

Breakthrough Energy Ventures is an investor-led venture capital firm based in Kirkland, Washington, focused on climate and energy technology. It makes minority investments across seed, early, and later stages in companies delivering environmental services, climate technology, and cleantech solutions. The firm seeks scalable technologies that provide reliable, affordable power while reducing greenhouse gas emissions and supports innovations that address energy access, infrastructure, and transportation needs. Its mission emphasizes patient, impact-oriented investing to accelerate the transition to low-emission energy systems.