Elevate Ventures is a nonprofit organization that supports Indiana-based startups and growing companies with high growth potential. Through rigorous business analysis and advisory services, it helps identify market needs and guide ventures from research to product development to market. Beyond capital, Elevate Ventures partners with entrepreneurs, investors, and state and local organizations to address barriers such as management, business development, talent recruitment and retention, and technology development, aiming to sustain long-term growth. The organization emphasizes unbiased, in-depth assessments and long-term resources to improve financial viability and return on investment while contributing to local job creation and economic development in Indiana.

High Alpha is an Indianapolis-based company that operates as a venture studio and early-stage investor focused on B2B software as a service. Through its studio arm, High Alpha Studio, it conceives, launches, and scales B2B SaaS ventures by offering a comprehensive mix of services, including design, finance, talent, marketing, branding, and go-to-market support. The organization also invests through High Alpha Capital, backing High Alpha Studio ventures and other emerging B2B SaaS companies. The combined studio and investment model aims to reduce friction, accelerate product development, and help portfolio companies achieve enterprise-scale growth in the software and SaaS sectors across the United States.

Allos Ventures is a venture capital firm focused on early-stage investments in business-to-business software and technology-enabled services in the Midwest. The firm is based in Carmel, Indiana, with a presence in Cincinnati, Ohio, and backs entrepreneurs to accelerate growth and build value. Founded in 2010, Allos Ventures targets U.S. and Midwest B2B software and IT-enabled services, often pursuing minority stake investments.

Collina Ventures is a venture capital firm based in Carmel, Indiana. It makes minority investments in technology companies across seed, early, and later stages, with an emphasis on software and technology sectors in Central Indiana.

VisionTech Partners is an angel investment group based in Indianapolis that backs early-stage and growth technology companies in Indiana and the Midwest. It focuses on sectors including life sciences, software as a service, Internet of Things, advanced materials, supply chain, and hardware. The group seeks strong management teams pursuing funding rounds of roughly $200,000 to $1 million in convertible debt or equity, with pre-money valuations under $10 million. Ideal portfolio companies are within 12 months of breakeven or have a clear plan to reach a Series A and demonstrate milestones, with an exit horizon of three to seven years. The firm emphasizes companies with novel products or services and clear competitive advantages in large markets.

IU Ventures is the corporate venture capital arm of Indiana University, based in Bloomington, Indiana. It supports the university community by providing strategic investment and resources to pursue new venture opportunities, including assistance to students, faculty, staff, and alumni seeking to develop startups. The organization targets investments in business-to-business, healthcare, and technology sectors, aiming to connect aspiring ventures with university expertise and networks, and to foster entrepreneurship within the IU ecosystem.

Hyde Park Venture Partners is an Illinois-based venture capital firm that backs early-stage technology companies in the Midwest. Based in Chicago with an Indianapolis office, the firm concentrates on seed and Series A rounds for high-growth startups in software, SaaS, marketplaces, and technology-enabled services, with emphasis on B2B software and enterprise software, consumer marketplaces, and healthcare IT. Hyde Park Venture Partners engages actively with portfolio companies, assisting with product development, business strategy, and financing, and often assumes board or advisory roles to support growth and exits. The firm emphasizes founder partnerships and leverages its Midwest network to help portfolio companies scale across sectors such as AI-enabled services, logistics, fintech, and healthcare technology.

Heron Capital is a private equity and venture capital firm based in Indianapolis, Indiana, focused on healthcare and life sciences, including therapeutic devices, diagnostics, medical devices, and related manufacturing. It invests in United States and Canada-based companies, with a Midwest emphasis and proximity to Indianapolis. The firm targets buyouts, recapitalizations, expansions, and turnaround opportunities in small- to middle-market businesses, often seeking a controlling stake and board seats. Typical investments range from $1 to $10 million of equity in companies with at least $2 million in revenue and earnings of $0.5 million to $4 million, aiming to unlock value through operational improvements and strategic growth. It emphasizes collaboration with management teams and leverages a network of scientists, physicians, entrepreneurs, and industry leaders to support portfolio companies.

Gravity Ventures is a venture capital investment firm based in Indianapolis, Indiana. Founded in 2008, it focuses on early-stage technology and tech-enabled startups, investing across a range of industries and providing capital and strategic support to help startups scale.

Charmides Capital is a venture capital firm based in Carmel, Indiana, focusing on early‑stage software companies, primarily B2B SaaS, in Indiana and the Midwest. It co‑invests with institutional investors to fund startups and provides strategic value beyond capital. The firm combines backgrounds in entrepreneurship, finance, and technology to offer tailored investment solutions and active support to portfolio companies. An advisory board with diverse expertise guides its investment approach, and Charmides Capital engages with the local business community to identify opportunities in software, technology, healthcare, and consumer applications. Founded in 2015, the firm aims to foster growth and rapid expansion of ventures with strong potential through disciplined underwriting and value‑added guidance.

Boomerang Ventures is a venture capital firm established in 2019 and based in Indianapolis, Indiana. The firm concentrates its investments in healthcare and related technology, including connected medical devices, digital health, tech-enabled health services, and healthcare informatics, and it also engages with information technology and life sciences startups within the sector.

Flywheel Fund is a Bloomington, Indiana-based venture capital firm founded in 2020 that invests in early-stage technology startups, with a focus on Indiana-based companies. It backs ventures across life sciences, medical devices, and software-enabled technology, reflecting an emphasis on high-potential startups at the intersection of software and hardware.

OneCause is a fundraising technology company that provides a comprehensive platform for nonprofits, including online giving, mobile bidding, auction management, peer-to-peer fundraising, event management, registration and checkout, ticketing, and payment processing, to simplify fundraising and enhance donor engagement.

Health Cloud Capital is a growth investment firm based in Indianapolis that focuses on healthcare IT and cloud-enabled healthcare software. Founded in 2017, it pursues growth opportunities in cloud-based healthcare SaaS companies with strong recurring revenue, typically seeking at least $5 million in annual recurring revenue, and aims to improve healthcare outcomes through data-driven approaches. The firm leverages expertise in healthcare, diagnostics, and information technology to partner with portfolio companies, supporting scaling and operational growth in the cloud, software-as-a-service, and digital health segments.

HG Ventures is the corporate venture capital arm of The Heritage Group, based in Indianapolis. Founded in 2018, it invests in early and growth-stage companies developing technologies and systems across transportation infrastructure, environmental services, specialty chemicals, energy, climate tech, supply chain, manufacturing and food tech, often pursuing investments up to about $20 million. The firm leverages the Heritage Group’s operating companies and research center to provide strategic value and access to domain expertise for portfolio companies.

Spring Mill Venture Partners is a venture capital firm that funds seed and early-stage information technology and life sciences companies in Indiana and the broader Midwest. The firm provides capital and strategic and tactical support to help high-growth startups grow and prosper, focusing on information technology, healthcare technology, and life sciences sectors. Founded in 2004 and based in Carmel, Indiana, it targets companies in Indiana, Illinois, Kentucky, Michigan, and Ohio.

Ascension is a large nonprofit Catholic health system serving communities across Florida, Illinois, Indiana, Kansas, Maryland, Oklahoma, Tennessee, Texas, Wisconsin, and beyond, comprising 94 hospitals and 23,000 affiliated providers. It is dedicated to delivering compassionate, accessible care and offers a broad range of services and specialties, including pediatric care, oncology, and genetic testing. The system emphasizes patient portals for accessing medical records and secure online billing, price transparency, interpreter services in multiple languages, and community health initiatives. It supports initiatives such as music therapy for newborns and emotional support for patients, while encouraging volunteerism and philanthropy to sustain clinical and community programs.

SV Angel is a San Francisco-based venture capital firm with more than 30 years of experience investing in technology companies. It focuses on seed to early-stage opportunities in software, artificial intelligence and other tech sectors, primarily across North America, with notable activity in New York and San Francisco. The firm provides strategic support to portfolio companies, including business development, financing, M&A and other advisory services, helping startups scale and bring innovative products to market. SV Angel is known for backing a broad pipeline of early-stage ventures and adhering to values such as trust, loyalty and integrity.

Capital Midwest Fund is a venture capital firm based in Mequon, Wisconsin, focused on early-stage investments in the U.S. Midwest and Central United States. It backs companies across sectors such as life sciences, information technology, advanced manufacturing, healthcare, B2B services, consumer goods, media, transportation and health technology, seeking growth opportunities in the Midwest and nationwide. Since its founding in 2010, the firm has supported startups that aim to scale through technology-enabled products and services, with a preference for companies that leverage regional strengths in manufacturing, healthcare and software. Capital Midwest Fund emphasizes constructive, hands-on partnering to help portfolio companies achieve scale, profitability and competitive advantage.

Triathlon Medical Ventures is an Ohio-based investment firm focusing on life sciences, biomedicine, medical devices, biotechnology, and diagnostics, primarily in the Midwest. Founded in the early 2000s, it invested across seed to expansion stages and often led deals, seeking companies with proprietary biomedical technology addressing major healthcare needs. The firm maintained a Midwest footprint with a Cincinnati headquarters and additional offices in Indiana, Kentucky, and Michigan.

Heartland Ventures is a Midwest-based venture capital firm headquartered in Columbus, Ohio, focused on industrial technology and related sectors such as construction, manufacturing, agriculture, logistics, and human resources technology. The firm backs early-stage companies, typically Seed to Series A, with check sizes in the lower-mid range, and leverages a broad network of industrial operators across manufacturing, logistics, real estate, and construction to connect startups with corporate decision makers. It aims to accelerate revenue growth and foster early technology adoption in lower-middle-market and family-owned businesses, bridging Midwest expertise with technology developed on the coasts. The firm operates across several cities including Cincinnati, Columbus, Indianapolis, Louisville, and New York City, emphasizing sustainable partnerships with founders and management teams.

Village Ventures is a venture capital firm founded in 2000 and based in Williamstown, Massachusetts, with additional offices historically in Bloomington, Indiana; New York, New York; and Denver, Colorado. It focused on seed and early-stage investments across sectors including consumer, media and retail, healthcare and life sciences, business services, information technology, financial services and fintech, as well as consumer internet and e-commerce. The firm typically invested between 0.5 million and 5 million dollars per portfolio company and aimed to acquire about 20 percent equity, often pursuing co-investment with groups familiar to the firm. Its geographic focus included New England and other U.S. markets such as Florida, New Mexico and Indiana. Village Ventures concentrated on early-stage opportunities with revenues under 10 million dollars for growth-stage prospects, and on seed-stage ventures with no revenue. It operated primarily as an early-stage investor within the United States.

M25 is a Chicago-based venture capital firm focused on the Midwest, founded in 2015 by Victor Gutwein and Mike Asem. It invests in pre-seed and seed-stage technology startups headquartered in the Midwest and has backed a large portfolio across multiple cities and states in the region. The firm emphasizes an analytical approach and collaborative partnership with founders to support growth, aiming to be a key participant in the Midwest startup ecosystem across various technology sectors.

Sixty8 Capital is a seed-stage venture capital firm based in Indianapolis, Indiana. It focuses on investing in tech, tech-enabled, and direct-to-consumer startups, with a particular emphasis on founders from Black, Brown, women, and LGBTQ+-led ventures. Founded in 2019 by Kelli Jones and Paul Ehlinger, the firm is supported by Allos Ventures, which has about 45 years of venture capital experience.

Lumina Impact Ventures is the corporate venture arm of Lumina Foundation and makes impact investments in education technology. It extends the foundation’s work beyond grant funding by engaging the private sector to generate ideas, build knowledge, and attract new capital to expand learning opportunities. The arm supports entrepreneurs of color and founders from low-income backgrounds and fosters a collaborative, founder-friendly ecosystem. By leveraging Lumina’s networks, it connects portfolio companies with trusted advisors and other non-financial resources that can accelerate growth. It primarily invests in early-stage companies developing innovative technologies and tech-enabled platforms that create opportunities for people to learn after high school.

Mission Innovation Network is a venture capital firm founded in 2020 and based in South Bend, Indiana. It operates as a network-based investor that supports mission-driven local companies by making early-stage investments in sectors such as consumer health and wellness, ESG fintech, jobs and education, sustainability, consumer basic needs, social media, and community collaboration.

Rival is a Fort Wayne, Indiana-based venture capital firm founded in 2023 that provides financial and business development support to innovation and technology companies. It invests across sectors including manufacturing, retail, general contracting, distribution and development, and also operates as a venture builder to advance portfolio companies.

Ivy Ventures is a venture capital firm founded in 2022 and based in Carmel, Indiana. It provides capital and resources to early-stage companies seeking roughly $500,000 to $2,000,000, and aligns diligence with input from its team, select advisors, and an investment committee. The firm targets United States companies operating in enterprise software, life sciences, healthcare, information technology, medical, and hard technology sectors.

Pearl Street Venture Funds is a venture capital firm based in Indianapolis, Indiana, investing in early-stage life sciences companies, including biotech, pharmaceutical, medical device, and agri-bio ventures, and backing therapeutic products that leverage next-generation technologies. The firm can serve as a lead or co-investor and seeks opportunities primarily in Indiana, with additional offices in Los Angeles, West Lafayette, San Diego, and Gaithersburg.

Start Something Ventures is an angel investment group based in Indianapolis, Indiana, that backs early-stage SaaS and tech-enabled businesses, including software-as-a-service and business-to-business products and services within the technology industry.

Roll Tack Ventures is a Midwest-based venture capital firm founded in 2024 with offices in Indianapolis, IN, Ann Arbor, MI, and Cincinnati, OH. It supports B2B technology startups that strengthen the middle-market corporate tech stack, helping companies grow, boost efficiency, and improve protection. The firm collaborates with technology entrepreneurs who address pressing needs and tends to back startups that have Midwest clientele or a Midwest presence. Roll Tack makes investments once a startup has demonstrated product-market fit and is prepared to scale.

Ground Game Ventures is a venture capital firm founded in 2022 and based in Indianapolis, Indiana. It focuses on early-revenue, seed-stage B2B and SaaS startups.

Round One Capital is a venture capital firm and seed investor founded in 2021 and based in Indianapolis, Indiana. It focuses on backing early-stage technology companies and invests across sectors including insurance, healthcare, and consumer products.

SignalFire is a San Francisco-based venture capital firm founded in 2013 that backs seed to growth-stage technology companies. It focuses on data-driven investing and advisory across sectors including artificial intelligence, machine learning, software-as-a-service, health tech, pharmatech, dev tools, cybersecurity, fintech, consumer tech, and e-commerce in the United States and the Americas. The firm emphasizes a centralized, data-informed approach and a distributed network of entrepreneurs, product and engineering leaders, and seasoned investors to support recruiting, business development, customer acquisition, and community education. It provides tailored guidance to help founders address talent, strategy, and market-scale challenges.

Norwest is a venture capital and growth equity investment firm that focuses on venture and growth-stage companies. Since its inception, it has invested in more than 600 companies and partnered with over 140 active companies across its venture and growth equity portfolio. The firm backs early to late-stage companies across sectors with a focus on consumer, enterprise, and healthcare, and it provides a deep network of connections, operating experience, and a broad range of services to help CEOs and founders scale their businesses.

Revolution is a Washington, D.C.-based venture capital firm founded in 2005 by Steve Case that backs technology-enabled startups and growth-stage companies across the United States. The firm focuses on sectors such as consumer internet, media and entertainment, software and services, financial and health care, energy, and related information technology fields, often pursuing sizable investments and taking active roles in portfolio companies. Revolution operates through a family of funds and initiatives, including early-stage and growth vehicles, and emphasizes investing in startups outside traditional coastal hubs through programs like Rise of the Rest to spur regional innovation and scale. The firm supports entrepreneurs from inception through later stages, collaborating with regional ecosystem leaders and co-investors to help companies expand nationally.

Good Growth Capital is a venture capital firm based in Charleston, South Carolina, that focuses on early-stage investments in science- and technology-driven startups. The firm backs companies across life sciences, green technologies, data sciences, software, and related sectors in the United States, often targeting opportunities where transformative innovation can address significant market needs. It supports portfolio companies through mentorship and operational expertise, with an emphasis on diverse leadership and teams. The firm typically invests in seed and Series B rounds, helping ventures bridge research, product development, and commercial execution while aiming to generate strong returns and broader societal impact.

Mutual Capital Partners is a venture capital firm based in Westlake, Ohio, focused on healthcare information technology and medical devices. The firm targets early-stage investments in the United States, prioritizing companies with strong leadership, established customer bases, and revenue, especially those located outside major tech hubs in the Midwest. Beyond capital, it provides active partnership, due diligence support, and ongoing guidance to portfolio companies, leveraging its network of investors. The firm emphasizes prompt evaluation and practical resources to help healthcare IT and medical device startups grow.

IrishAngels is an angel group and early-stage venture firm that backs seed and early-stage startups. Through a wide investor network, it provides strategic value beyond capital, supporting portfolio companies from due diligence through growth. The firm emphasizes a founder-friendly approach and actively engages with portfolio companies to help them build and scale. It backs companies across software, consumer products, artificial intelligence and machine learning, fintech, health technology, and related sectors, typically participating in seed, seed+ and Series A rounds.

Cultivation Capital is a St. Louis–based private equity and venture capital firm focusing on early-stage investments in life sciences, healthcare, software and information technology, agriculture technology, and geospatial sectors in the United States. Founded in 2012, the firm backs companies from seed through Series B rounds, providing capital and strategic guidance to help portfolio companies grow. Cultivation Capital operates as an investment adviser.

SOSV is a global venture capital firm founded in 1995 and headquartered in New Jersey. The firm focuses on seed-to-growth investments in deep tech sectors, including biotech and life sciences, hardware and robotics, and cross-border software with emphasis on markets in Asia. It supports startups from early stages with investment capital as well as resources such as laboratories, collaborative spaces, and expert mentorship to accelerate product development and market traction. SOSV operates purpose-built programs to help portfolio companies raise follow-on funding, scale operations, and reach customers, often through structured matchmaking and access to a global network of investors. With a broad portfolio spanning hundreds of companies worldwide, SOSV aims to foster innovation, build vibrant entrepreneurial ecosystems, and contribute to sustainable technological advancement.

Tyson Foods is a modern multinational protein-focused food company that produces about 20% of the beef, pork, and chicken in the United States. It markets a broad portfolio of foods under brands such as Tyson, Jimmy Dean, Hillshire Farm, BallPark, Wright, Aidell's, and State Fair. The company serves a wide range of customers, including national restaurant chains, schools, military bases, hospitals, nursing homes, and international buyers, and it operates across all major retail channels, from club stores to grocery and discount outlets. Tyson Foods is a leading provider of protein to both foodservice and retail customers, with integrated supply and a diversified mix of raw and prepared foods. The business model emphasizes scale and brand breadth to meet demand in consumer and institutional markets.

RA Capital Management is a Boston-based investment firm that provides multi-stage capital to public and private healthcare, life sciences, and planetary health companies. The firm supports management teams from early seed rounds to later financings, seeking to drive value through scientific and clinical data, product development, and commercialization. It complements capital with value-added services such as board representation, executive recruitment, and market intelligence through its TechAtlas research platform. The company also operates Raven, a healthcare incubator that helps entrepreneurs build biomedical ventures, and emphasizes a collaborative, data-driven approach and long-term relationships. RA Capital pursues social responsibility by advocating for affordable medicines and industry advancement, and it invests across U.S. and European opportunities, including early-stage and growth-stage rounds.

DSM Venturing is the corporate venture capital arm of Royal DSM, established in 2001 and headquartered in Heerlen, Netherlands. The firm focuses on investing in start-up companies that develop innovative products and services within the life sciences sector, which encompasses both animal and human health and nutrition. Over the years, DSM Venturing has invested in more than fifty emerging companies across the United States, Europe, and Israel. Its primary objective is to generate strategic options and enhance value for DSM and its broader ecosystem while achieving sustainable venture-grade investment returns.

Straylight Capital is a venture capital firm based in Ann Arbor, Michigan, founded in 2002, that seeks to invest in B2B software, information technology, and SaaS companies across North America.

New Enterprise Associates is a venture capital firm founded in 1977 and based in Menlo Park, California, with a global investment reach. It provides capital and operational support to early, growth, and later-stage companies across a wide range of industries, including software, consumer technology, healthcare technology, life sciences, energy technology, infrastructure, and AI-enabled services. NEA collaborates with founders to address technical challenges, guide product development, and expand markets, leveraging its domain expertise to help portfolio companies scale from seed stages through IPO. The firm invests across the United States, Asia, and other regions, often supporting companies from early stages to scale, and has a long track record that includes numerous IPOs and acquisitions. NEA emphasizes a hands-on partnership approach and seeks opportunities across sectors that enable transformational businesses through technology and data-driven innovation.

OrbiMed is a global healthcare investment firm based in New York that funds companies across the healthcare spectrum. It uses multiple strategies, including private equity for startups and growth-stage companies, private credit and royalty financing for intellectual property and medical diagnostics, and public equity investments. The firm targets biopharmaceuticals, biotechnology, medical devices, diagnostics, digital health, and health IT, supporting development of new therapies and health technologies. OrbiMed operates internationally with offices in major markets and manages substantial assets across public and private investments, staffed by a team of professionals to identify opportunities and support portfolio companies.

Keshif Ventures is a San Diego-based venture capital firm founded in 2012 that provides early-stage funding to technology-driven companies in the San Diego region. The firm targets investments in infrastructure, technology, and enterprise solutions, with interests in media and big data sectors.

Ceres Venture Fund is a Midwest-focused venture capital firm based in Illinois that concentrates on early-stage investments in high-growth companies. It targets opportunities in healthcare, information technology, and business services, and seeks to partner with proven entrepreneurs, providing them with resources and strategic support to accelerate growth and scale their businesses.

Greylock Partners is a Menlo Park-based venture capital firm founded in 1965 that invests across seed to growth stages in consumer and enterprise software and related information technology sectors. The firm backs entrepreneurs who redefine markets and often takes board seats to help guide portfolio companies such as Airbnb, AppDynamics, Cloudera, Docker, Dropbox, Facebook, LinkedIn, Palo Alto Networks, Pure Storage, and Workday. With offices in San Francisco and Wellesley, Greylock supports startups globally and focuses on software-enabled businesses including cloud/SaaS, data analytics, security, and services.