Simulations Plus
Simulations Plus is a developer of specialized software focused on Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) as well as Physiologically-Based Pharmacokinetic (PBPK) modeling and simulation. Founded in 1996 and headquartered in Lancaster, California, the company serves various sectors, including pharmaceuticals, biotechnology, chemicals, cosmetics, and food ingredients. Its software enables pharmaceutical scientists to predict key endpoints and dynamics in silico, effectively lowering research and development costs while facilitating informed decision-making. Simulations Plus employs over 60 individuals and has a consulting team based in Buffalo, New York. The company’s technology is licensed by 19 of the top 20 pharmaceutical companies, along with a range of mid-sized and smaller firms, as well as major regulatory agencies. Additionally, trusted distributors manage sales and scientific support in Asian markets.
Immunetrics
Acquisition in 2023
Immunetrics, Inc. is a biosimulation company based in Pittsburgh, Pennsylvania, focused on developing biological models and tools for mechanistic modeling in drug discovery and development. Established in 2003, the company offers a software platform called Aegis, which supports model developers in creating disease-specific models and virtual populations. Immunetrics provides a range of modeling services, including pharmacology modeling that integrates biological pathways to predict clinical outcomes of therapeutic interventions in various medical conditions, particularly acute and chronic inflammatory diseases and autoimmune disorders. Additionally, the company offers consulting services for mechanistic and statistical modeling, as well as data analysis, enabling researchers to better understand and analyze human diseases and syndromes.
Lixoft
Acquisition in 2020
Lixoft specializes in developing modeling and simulation software aimed at enhancing drug development processes. The company's platform focuses on model-based drug development, providing user-friendly tools that facilitate population analysis across pre-clinical and clinical trials. By bridging the gap between different stages of drug development, Lixoft's solutions enable drug developers to effectively share and synthesize information, ultimately reducing costs and increasing the likelihood of success in bringing new drugs to market.
DILIsym Services
Acquisition in 2017
DILIsym Services, Inc. specializes in the development of drug-induced liver injury (DILI) simulation software for the pharmaceutical industry, with its flagship product, DILIsym, designed to create predictive models of DILI. This software supports liver safety assessments during clinical drug development, facilitating in vitro to in vivo extrapolation, translating preclinical data into clinical trial designs, and assessing the effects of patient variability on hepatotoxicity predictions. DILIsym includes specialized modules for mitochondrial toxicity, innate immunity, and bile acids. The company also offers NAFLDsym, a tool for evaluating treatments for non-alcoholic fatty liver diseases, as well as consulting services related to its software. Founded in 2015 and based in Research Triangle Park, North Carolina, DILIsym Services originated from the Hamner Institutes, acquiring comprehensive intellectual property and materials for its software. As of 2017, it operates as a subsidiary of Simulations Plus, Inc.
Cognigen Corporation
Acquisition in 2014
Cognigen, established in 1992, specializes in clinical pharmacology and pharmacometric consulting services. The company collaborates with leading pharmaceutical and biotechnology firms, as well as global health organizations and regulatory agencies, to support the development of over 100 drugs. Cognigen offers a range of services, including clinical trial simulations, exposure-response evaluations, and data management. They also provide analysis dataset creation and documentation services, ensuring meticulous attention to detail in their work. Through its extensive expertise in pharmacology, Cognigen plays a vital role in advancing drug development and regulatory compliance.
Bioreason
Acquisition in 2005
Bioreason is a privately held company that specializes in developing software research tools for the pharmaceutical and biotechnology sectors. The company focuses on knowledge discovery and management systems, particularly for structure-activity relationships. Its software solutions facilitate structure-based classification and automated reasoning, and they integrate various data sources to enhance decision-making. Additionally, Bioreason provides support interfaces designed for the needs of chemists and biologists, aiming to streamline research processes and improve outcomes in drug development.
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