SkyRiver Ventures

Holobiome is a biotechnology company based in Cambridge, Massachusetts, founded in 2015. The company focuses on developing microbiome-based therapeutics aimed at addressing diseases of the enteric and central nervous systems. Holobiome's innovative approach involves mapping and manipulating the gut-brain axis through next-generation probiotics, enabling the treatment of mental health disorders such as depression and anxiety, as well as enhancing metabolic and immune responses. By leveraging insights into the human gut microbiome, Holobiome seeks to provide effective therapies that allow patients to recover from their conditions with minimal discomfort.

Material Evolution is a manufacturing company focused on decarbonizing the cement industry through AI and machine learning-enabled chemistry and a low-capital, energy-efficient production process. It develops smart, sustainable concrete and a cement replacement made from hyper-local waste streams, with the aim of rapidly reducing carbon emissions and helping construction sectors meet their sustainability goals.

Geminus.AI, Inc. is a company based in Palo Alto, California, that specializes in developing artificial intelligence systems tailored for industrial processes. Founded in 1990, Geminus creates a platform designed to empower engineers and industrial operators to make rapid and informed decisions in environments characterized by high uncertainty. The company's offerings focus on self-optimized design and predictive operational intelligence, enhancing the performance and efficiency of various industrial assets, including refineries, power plants, satellites, and ships. By leveraging advanced AI applications, Geminus aims to support operators and engineering service providers in improving their operational capabilities.