SOSV

Capro-X is an ag-tech company focused on sustainability in the dairy industry. It develops fermentation bioprocess technology to convert acid whey, a dairy waste stream, into valuable products such as bio-oils, biofuels, and bioplastics, while producing clean water. The WheyAway treatment uses naturally occurring, non-GMO microbes to upgrade dairy waste on site at the point of generation. By upcycling acid from dairy waste, Capro-X helps dairy producers reduce waste and improve sustainability and yield over time. Founded in 2017 and based in Ithaca, New York, Capro-X serves dairy processors seeking to turn waste streams into value.

Particle Industries, Inc. is a provider of a comprehensive platform designed for the prototyping, scaling, and management of Internet of Things (IoT) products. The company offers a range of hardware development kits, including the Photon for Wi-Fi projects and the Electron for cellular-connected devices, along with various accessories like antennas and USB shields. Particle also delivers software tools such as Tinker, a mobile application for remote control, and Particle Build, a web-based development environment that allows users to write and deploy code easily. Its cloud platform facilitates secure interactions with connected devices through modern APIs, supporting developers in creating intelligent web services. With over 150,000 product builders across more than 170 countries, including notable clients like NASA and SpaceX, Particle has established itself as a key player in the IoT landscape. Founded in 2012 and headquartered in San Francisco, California, with an additional office in Shenzhen, China, the company has been recognized for its innovation and impact in the IoT sector.

Prellis Biologics is a biotechnology company based in San Francisco, founded in 2016, focused on bioprinting vascularized human tissues and organs for drug development, disease modeling, and transplantation. Its platform enables rapid, high-resolution printing of tissues and organoids, including lymph node models, to reproduce human immune responses. This capability supports antibody discovery, immunogenicity assessment, and tumor–immune studies, aiming to accelerate early-stage drug discovery and translational pharmacology while advancing the development of tissue and organ therapies.

Founded in 2016, Abbot's Butcher produces high-quality, small-batch plant-based meat products. Their allergen-friendly range includes items like chopped chick'n, beef sausage, and chorizo, crafted from whole food ingredients.

Founded in 2018, Somatic specializes in robotic cleaning services for commercial bathrooms. Its robots clean restrooms via virtual reality programming, reducing operational costs by up to 50% and improving hygiene.

Tensorfield Agriculture is a company based in San Jose, California, specializing in the development and manufacture of advanced agricultural machinery tailored for specialty row crops. Founded in 2018, the company focuses on innovative solutions that promote sustainable farming practices in a post-herbicide environment. Tensorfield Agriculture's machinery includes robots equipped with computer vision technology that perform selective, non-invasive weeding through thermal micro-dosing techniques. This approach helps farmers combat herbicide resistance while ensuring the continued supply of safe and sustainable fresh food. The company's commitment to enhancing agricultural efficiency positions it at the forefront of modern farming solutions.

Ten63 Therapeutics, Inc. is a biotechnology company based in Chapel Hill, North Carolina, focused on developing potent therapeutics for medically validated yet undruggable targets. Founded in 2017, the company utilizes its innovative platform, COPPER, which combines machine learning-based computational chemistry with advanced physical modeling to explore an extensive chemical space. This approach allows Ten63 Therapeutics to discover novel drug candidates for some of the most lethal diseases by employing proprietary algorithms for scaffold redesign and optimizing chemical design. By integrating these technologies, the company aims to produce durable therapies and improve drug resistance prediction, ultimately addressing challenges in drug development for previously intractable targets.

Founded in 2023, AlkaLi Labs is a biotechnology company based in San Francisco. It specializes in recovering critical minerals like lithium and cobalt from industrial waste streams using bioengineering solutions.

Brightwater Tools, headquartered in Vermont, is a woman-led startup specializing in sustainable sanitation solutions. The company has developed a unique, building-scale wastewater nutrient recovery system that transforms high-strength wastewater into natural, nutrient-rich fertilizer. This process not only reduces harmful algal blooms by minimizing nutrient discharge into waterways but also promotes a circular economy by recycling valuable resources. Brightwater Tools' system comprises three proprietary pieces of equipment, each facilitating key wastewater processes and available for individual or combined sale. The company aims to become a significant equipment provider in this industry, with a strong customer base expected as it completes prototype and beta testing.

Renewell Energy develops gravity-based, renewable energy storage that repurposes idle oil and gas wells. The technology converts inactive wells into a low-cost, flexible storage network by lowering a weight down a repurposed wellbore to push electricity onto the grid when demand is high and raising it back up when demand is low, effectively storing energy as gravitational potential. The approach targets zero-self-discharge storage and aims to abate greenhouse gas emissions by utilizing existing oil and gas infrastructure to create a scalable energy storage solution. The company is based in Bakersfield, California.

Quorum Earth, based in Brooklyn, New York, is a pioneering agricultural technology company. It specializes in the development of innovative, eco-friendly pesticides, harnessing the power of the fungal kingdom to create products that are safe for the planet and effective in controlling pests. Currently, the company operates in stealth mode.

OneSkin is a biotechnology company focused on skin aging and longevity that develops testing platforms and consumer products. It uses animal-free three-dimensional human skin models to evaluate the safety and efficacy of cosmetic ingredients and anti-aging compounds, supporting research and validation for the cosmetic and ingredient supplier industries. The company has developed a proprietary peptide, OS-01, intended to reduce skin biological age by decreasing the accumulation of aged cells, improving cellular repair, and strengthening the epidermal barrier. Its consumer offering includes a vegan topical product based on OS-01 designed for all skin types, marketed through its website. The business combines in vitro testing services with product development to address root causes of skin aging and support proper skin cell function.

Synplexity is a biotechnology company located in New Castle, Delaware, specializing in mutational scanning and multiplexed gene synthesis through advanced artificial intelligence technology. The company operates a large-scale gene synthesis and proteomics discovery platform that utilizes microdroplets as microreactors. This innovative approach allows for the efficient creation of multiplex gene libraries, which have applications across various sectors, including therapeutics, biomanufacturing, agriculture, and climate systems. Synplexity aims to drive advancements in healthcare and other industries through its cutting-edge genetic technologies.

Founded in 2022 and headquartered in Berkeley, California, Laguna Bio develops a drug discovery platform designed to selectively activate and expand the innate immune system against cancer. The company focuses on providing a specific type of T cell for the immune system to fight solid tumors by increasing the response rate of bispecific antibody drugs.

Terran Robotics is a construction company based in Bloomington, Indiana, that focuses on the integration of artificial intelligence and robotics in home construction. The company specializes in automated adobe wall building, utilizing a custom-designed cable-driven robot to create three-dimensional printed homes. This innovative approach enhances traditional earthen building techniques, offering features such as fire resistance and superior sound dampening. By leveraging advanced technology, Terran Robotics aims to significantly reduce housing costs, lower energy expenses, and promote environmentally friendly construction practices.

Founded in 2021, Sóliome is a biotechnology company based in San Francisco, California. It specializes in developing protein-based sunscreens that are safe and effective, using molecules naturally produced by the human body to protect against harmful UV rays.

Gatehouse Bio is a biotech company based in Waltham, Massachusetts, founded in 2016. The company specializes in the development of therapies utilizing a novel bioinformatics platform that focuses on small ribonucleic acid (RNA) biomarkers. This platform is designed to classify patient samples with binary accuracy and identifies disease-associated mutations, enabling the creation of targeted therapeutics. By employing artificial intelligence, Gatehouse Bio aims to analyze small RNA genes and design oligonucleotides that can effectively counteract the effects of these mutations. Their research and development efforts target therapeutic areas with known heterogeneity, such as fibrosis, inflammation, and neurodegeneration, with the goal of unlocking the potential for improved patient outcomes through personalized medicine.

Capro-X is an ag-tech company focused on sustainability in the dairy industry. It develops fermentation bioprocess technology to convert acid whey, a dairy waste stream, into valuable products such as bio-oils, biofuels, and bioplastics, while producing clean water. The WheyAway treatment uses naturally occurring, non-GMO microbes to upgrade dairy waste on site at the point of generation. By upcycling acid from dairy waste, Capro-X helps dairy producers reduce waste and improve sustainability and yield over time. Founded in 2017 and based in Ithaca, New York, Capro-X serves dairy processors seeking to turn waste streams into value.

Tensorfield Agriculture is a company based in San Jose, California, specializing in the development and manufacture of advanced agricultural machinery tailored for specialty row crops. Founded in 2018, the company focuses on innovative solutions that promote sustainable farming practices in a post-herbicide environment. Tensorfield Agriculture's machinery includes robots equipped with computer vision technology that perform selective, non-invasive weeding through thermal micro-dosing techniques. This approach helps farmers combat herbicide resistance while ensuring the continued supply of safe and sustainable fresh food. The company's commitment to enhancing agricultural efficiency positions it at the forefront of modern farming solutions.

Unspun, Inc. is a digital apparel company based in San Francisco, California, founded in 2015. It specializes in creating custom jeans tailored to individual consumers using advanced body scanning technology, fit algorithms, and additive manufacturing. The company aims to address environmental challenges by minimizing pattern-cutting waste and unsold inventory, thus contributing to a reduction in global carbon emissions. Unspun's innovative approach enables on-demand production of jeans in under ten minutes, utilizing localized manufacturing processes designed to be zero-waste. Its technology has gained recognition, including being named one of TIME's Best Inventions of 2019, and supports a B2B platform that facilitates digital customization for major apparel brands.

Situated in San Francisco, California, the company is presently functioning in stealth mode.

kegg is a fertility health tracking device from a San Francisco based company founded in 2017 that combines fertility tracking with pelvic floor exercises. The device analyzes changes in cervical fluids to detect the fertile window and ovulation up to seven days in advance, providing users with information to guide conception decisions. By collecting data from cervical fluids, it aims to support women’s health through improved diagnosis, monitoring, and planning related to fertility.

CellCrine focuses on discovering enzymes that transform cell culture for the cell-based meats industry. CellCrine was founded in 2021and was headquartered in United, States.

Particle Industries, Inc. is a provider of a comprehensive platform designed for the prototyping, scaling, and management of Internet of Things (IoT) products. The company offers a range of hardware development kits, including the Photon for Wi-Fi projects and the Electron for cellular-connected devices, along with various accessories like antennas and USB shields. Particle also delivers software tools such as Tinker, a mobile application for remote control, and Particle Build, a web-based development environment that allows users to write and deploy code easily. Its cloud platform facilitates secure interactions with connected devices through modern APIs, supporting developers in creating intelligent web services. With over 150,000 product builders across more than 170 countries, including notable clients like NASA and SpaceX, Particle has established itself as a key player in the IoT landscape. Founded in 2012 and headquartered in San Francisco, California, with an additional office in Shenzhen, China, the company has been recognized for its innovation and impact in the IoT sector.

Melio is a healthcare company based in Santa Clara, California, specializing in blood testing technology aimed at detecting prevalent infections. The company has developed a comprehensive blood test platform that identifies common pathogens responsible for bloodstream infections. Utilizing a patented melting technique followed by detailed analysis, Melio's technology enables quick and accurate identification of blood-based pathogens. This innovation allows healthcare providers to deliver timely and targeted treatment, addressing the urgent need for effective therapies while also contributing to the fight against antibiotic resistance.

Founded in 2020, Prolific Machines is a San Francisco-based biotech company dedicated to revolutionizing cell production for a sustainable future. It combines advanced technologies to enable large-scale cell manufacturing, aiming to improve therapeutic protein production for biotechnology and pharmaceutical companies.

Lief Therapeutics is a medical device company based in San Francisco, California, focused on enhancing at-home care for individuals dealing with post-traumatic stress disorder, depression, and anxiety. The company has developed a discreet bio-sensing patch that accurately measures heart rate and breath, allowing users to manage their natural stress response through vibratory biofeedback exercises. This wearable device helps users monitor their behaviors, emotions, and thoughts in real-time, fostering mindfulness and control throughout the day. Additionally, it supports clinicians by tracking patient progress, facilitating in-session training, and scheduling psychological assessments. Lief Therapeutics also offers the Lief Health Score application, which records thoughts, emotions, and sensations, enabling users to track daily progress and engage in tailored exercises. Founded in 2014, the company sells its products online, aiming to empower individuals in their mental health journeys.

Helex is a biotechnology company developing genomic medicines for kidney-related diseases. It leverages its own genomics data, bioinformatics, and an intelligent data-driven platform to design, verify, and deliver therapy-specific gRNAs, with a focus on non-viral targeted delivery and genome editing for renal indications. The company's platform uses data-driven deep-learning models and high-throughput sequencing data from CRISPR edits in human cell lines to generate reliable predictions and validate them in-house. By combining these capabilities, Helex aims to accelerate CRISPR-based drug research and the development of cell and gene therapies for kidney conditions, offering precise and scalable renal therapeutics.

Finless Foods is a biotechnology company that uses cellular agriculture to develop cell-cultured seafood products as sustainable alternatives for human consumption. It grows marine-animal cells to create seafood substitutes, including bluefin tuna, with the goal of offering responsibly produced options that support ocean health and reduce overfishing. Founded in 2017 and based in Emeryville, California, the company concentrates on expanding dietary choices while addressing environmental impacts of traditional seafood.

California Organic Fertilizers is a manufacturer of organic input materials that comply with Food Safety and National Organic Program standards. The company produces certified agricultural organic fertilizers designed to provide farmers with high plant-available nitrogen suitable for organic farming. Specializing in both liquid and dry fertilizers, California Organic Fertilizers sources its raw materials locally to support regional economies. The company is committed to the well-being of its workforce, communities, and the environment, ensuring that its products can be effectively used in organic farming operations and commercial landscape applications.

California Cultured is a food company that uses cellular agriculture to produce cocoa and coffee, with the aim of delivering sustainable, lab-grown ingredients. Its cocoa is described as less bitter and requiring less sugar to achieve flavor, enabling premium quality products with a smaller environmental footprint. The company seeks to address social and environmental concerns linked to traditional cocoa production by avoiding practices such as slavery, deforestation, and child labor. California Cultured was founded in 2020 and is based in Davis, California.

VIA BioFuels is a biotechnology research company based in Houston, Texas, founded in 2023. The company specializes in the development of proprietary engineered yeast strains, specifically S. cerevisiae, which produce aromatic 3-methyl anisole (3-MA) from conventional ethanol feedstocks. VIA BioFuels’ technology is designed to be scalable, utilizing existing ethanol production methods and infrastructure. The high-purity 3-MA produced can be transformed into various valuable compounds, enhancing the market potential of the output and allowing consumers to substitute traditional fuels without blending restrictions.

Strados Labs, LLC is a medical technology company based in Philadelphia, Pennsylvania, specializing in respiratory health management through innovative sensor-based solutions. Founded in 2016, the company has developed a wearable device that provides real-time insights into breathing patterns, sounds, and speed. This device is equipped with clinical-grade biosensors and smart software, allowing for continuous monitoring of respiratory conditions such as asthma and chronic obstructive pulmonary disease. By connecting to a mobile application, Strados enables users and healthcare providers to access and analyze respiratory data, facilitating informed health decisions and remote patient monitoring.

AquaLith Advanced Materials specializes in the development of innovative lithium-ion battery materials. The company has secured exclusive rights to a portfolio of patents from the University of Maryland, which focus on advancements made by researchers in the field of chemical and materials engineering. AquaLith's technology includes an ultra-high energy cathode, a novel silicon anode, and a non-flammable aqueous electrolyte, all designed to enhance the performance of lithium-ion batteries. This technology addresses key challenges such as efficiency in low temperatures, faster charging times, and improved safety by reducing fire risks associated with short circuits. The company's materials aim to provide high energy density while being cost-effective and abundant, ultimately benefiting consumer electronics and other applications in need of reliable battery solutions.

Avisa Myko is a biotechnology company based in San Francisco, California. It specializes in the production of melanin, a natural pigment with applications in cosmetics, biomedicine, organic semiconductors, biosensors, and latex products. The company's patented technology enables large-scale production of soluble, affordable melanin, offering protection against ionizing radiation and contributing to better health and environmental sustainability.

XN Health is a medical device company founded in 2021 and based in Texas, USA. The company focuses on developing innovative healthcare solutions to assist mechanically ventilated patients in weaning off ventilators more efficiently. Its primary product utilizes phrenic nerve stimulation to induce diaphragm contractions, thereby mitigating the risks of diaphragm dysfunction associated with prolonged mechanical ventilation. By enhancing the weaning process, XN Health aims to improve patient outcomes and facilitate recovery in critical care settings.

Farmshelf Corp. is a Brooklyn-based company that designs and manages modular urban farms, specifically tailored for indoor environments. Founded in 2015, Farmshelf provides an automated hydroponic farming solution that allows users—whether at home or in restaurants—to grow a variety of fruits and vegetables in a compact, bookcase-sized unit. This innovative system is engineered to cultivate produce three times faster than traditional farming methods while utilizing 90 percent less water. The technology automatically manages watering and nutrient delivery, and it includes analytics to monitor plant growth, thereby reducing the need for packaging, pesticides, and food waste. Farmshelf aims to bring the benefits of fresh, locally grown food to urban settings, enhancing accessibility and sustainability in food production.

Founded in 2013, ZymoChem develops eco-friendly chemical production processes using engineered microbes. These processes convert renewable feedstocks like sugars into industrial chemicals, minimizing carbon loss and enabling cost-competitive bio-based manufacturing.

Perfect Day develops animal-free dairy proteins and dairy substitutes using fermentation to produce proteins that are nutritionally identical to cow’s milk. The company makes products including milk, cheese, yogurt, ice cream, and milk proteins without using animals. Its fermentation process uses yeast to convert plant-based sugars into dairy proteins, enabling products with the same taste, texture, and nutrition as traditional dairy while avoiding animal welfare concerns and reducing environmental impact. Founded in 2014 and headquartered in Emeryville, California, Perfect Day focuses on sustainable, vegan dairy alternatives that aim to appeal to both consumers and manufacturers seeking dairy-like ingredients without conventional dairy farming.

Chronus Health develops a portable diagnostic device for delivering point-of-care lab results in minutes. Its device enables real-time diagnosis at the point-of-care, improving time to care and patient outcomes.

Founded in 2011, Verdex Technologies specializes in the mass production of non-toxic nanofibers using proprietary green technology. The company designs, patents, and licenses equipment for filtration and biomedical purposes, creating advanced performance nanofiber materials for various applications such as engine filters, liquid filters, industrial air filters, waterproof textiles, medical packaging, and face masks.

Lura Health develops a non-invasive continuous health monitoring platform that uses saliva as a diagnostic fluid. The company integrates micro-sensors into orthodontic devices such as retainers, aligners, and brackets to continuously measure saliva analytes and securely transmit data to a smartphone app, enabling users to monitor oral health metrics and potentially support broader chronic disease management. Target markets include heart disease, chronic kidney disease, diabetes, and tooth decay. Founded in 2017, the company is based in Cambridge, Massachusetts.

Tensorfield Agriculture is a company based in San Jose, California, specializing in the development and manufacture of advanced agricultural machinery tailored for specialty row crops. Founded in 2018, the company focuses on innovative solutions that promote sustainable farming practices in a post-herbicide environment. Tensorfield Agriculture's machinery includes robots equipped with computer vision technology that perform selective, non-invasive weeding through thermal micro-dosing techniques. This approach helps farmers combat herbicide resistance while ensuring the continued supply of safe and sustainable fresh food. The company's commitment to enhancing agricultural efficiency positions it at the forefront of modern farming solutions.

Atlantic Fish Company is focused on producing cultivated seafood through cellular agriculture, operating from its headquarters in Raleigh-Durham, North Carolina. The company aims to provide sustainable seafood options by cultivating fish in a controlled environment. This innovative approach allows Atlantic Fish Company to offer fresh fish meat that maintains the natural taste while minimizing the environmental impact associated with traditional fishing practices. By leveraging cellular agriculture, the company seeks to meet the growing demand for sustainable protein sources.

Founded in 2014, Lingrove specializes in manufacturing eco-friendly bio-composite materials. Utilizing a proprietary process, they produce high-performance natural fiber composites from plant-based fibers and resins, aiming to reduce deforestation and embodied carbon in industries such as commercial interiors, transportation, and construction.

Prellis Biologics is a biotechnology company based in San Francisco, founded in 2016, focused on bioprinting vascularized human tissues and organs for drug development, disease modeling, and transplantation. Its platform enables rapid, high-resolution printing of tissues and organoids, including lymph node models, to reproduce human immune responses. This capability supports antibody discovery, immunogenicity assessment, and tumor–immune studies, aiming to accelerate early-stage drug discovery and translational pharmacology while advancing the development of tissue and organ therapies.

Founded in 2015, Bite Inc. specializes in digital ordering solutions for the hospitality industry. Its primary offerings include bitekiosk, a kiosk ordering software for guests, and biteFLASH, a QR code-based mobile interface for contactless ordering.

ViaBot Inc. specializes in developing autonomous outdoor robots tailored for commercial maintenance tasks. Founded in 2016 and headquartered in Sunnyvale, California, the company offers multi-functional robots that address various outdoor responsibilities, including sweeping, lawn mowing, and security. Their RUNO robots utilize advanced vision technology to monitor and scan properties, such as recognizing vehicle license plates. ViaBot's autonomous solutions feature modular technology, round-the-clock monitoring, easy scheduling, and long operational runtimes, thus enabling businesses like shopping malls and sports arenas to efficiently manage their outdoor environments. The company's commitment to ongoing updates ensures their robots remain effective and adaptable to changing needs.

BioAesthetics develops tissue-engineered nipple-areolar complex grafts to support breast reconstruction after mastectomy. The graft is designed as a scaffold for the patient's own cells to populate and regenerate the nipple and areola during reconstruction, aiming to improve cosmetic and reconstructive outcomes. The company originated as a Tulane University spin-out and was founded in 2015.

Particle Industries, Inc. is a provider of a comprehensive platform designed for the prototyping, scaling, and management of Internet of Things (IoT) products. The company offers a range of hardware development kits, including the Photon for Wi-Fi projects and the Electron for cellular-connected devices, along with various accessories like antennas and USB shields. Particle also delivers software tools such as Tinker, a mobile application for remote control, and Particle Build, a web-based development environment that allows users to write and deploy code easily. Its cloud platform facilitates secure interactions with connected devices through modern APIs, supporting developers in creating intelligent web services. With over 150,000 product builders across more than 170 countries, including notable clients like NASA and SpaceX, Particle has established itself as a key player in the IoT landscape. Founded in 2012 and headquartered in San Francisco, California, with an additional office in Shenzhen, China, the company has been recognized for its innovation and impact in the IoT sector.

Gatehouse Bio is a biotech company based in Waltham, Massachusetts, founded in 2016. The company specializes in the development of therapies utilizing a novel bioinformatics platform that focuses on small ribonucleic acid (RNA) biomarkers. This platform is designed to classify patient samples with binary accuracy and identifies disease-associated mutations, enabling the creation of targeted therapeutics. By employing artificial intelligence, Gatehouse Bio aims to analyze small RNA genes and design oligonucleotides that can effectively counteract the effects of these mutations. Their research and development efforts target therapeutic areas with known heterogeneity, such as fibrosis, inflammation, and neurodegeneration, with the goal of unlocking the potential for improved patient outcomes through personalized medicine.

Founded in 2014, QuantumCyte develops an automated tissue dissection system that uses digital maps to isolate regions of interest containing informative biomarkers. This platform aims to improve cancer outcomes by enabling precise cellular data analysis for predicting drug efficacy.

Avisa Myko is a biotechnology company based in San Francisco, California. It specializes in the production of melanin, a natural pigment with applications in cosmetics, biomedicine, organic semiconductors, biosensors, and latex products. The company's patented technology enables large-scale production of soluble, affordable melanin, offering protection against ionizing radiation and contributing to better health and environmental sustainability.

Bartesian Inc. is a manufacturer of a cocktail-making machine that enables customers to create customized, bar-quality cocktails at home using a capsule-based system. Founded in 2014 and headquartered in Chicago, Illinois, the company offers a robotic bartender that utilizes pre-mixed ingredient pods, allowing users to prepare a variety of cocktails, such as martinis and cosmos, at the press of a button. The machine combines alcohol, juices, bitters, and water from specialty pods, ensuring a seamless and authentic cocktail experience. Formerly known as MaxMixology Inc., the company adopted its current name in January 2015.

Renewell Energy develops gravity-based, renewable energy storage that repurposes idle oil and gas wells. The technology converts inactive wells into a low-cost, flexible storage network by lowering a weight down a repurposed wellbore to push electricity onto the grid when demand is high and raising it back up when demand is low, effectively storing energy as gravitational potential. The approach targets zero-self-discharge storage and aims to abate greenhouse gas emissions by utilizing existing oil and gas infrastructure to create a scalable energy storage solution. The company is based in Bakersfield, California.

Arculus Solutions is a company based in North Bethesda, Maryland, focused on enhancing the safety of natural gas transmission pipelines for the future transportation of hydrogen. It specializes in the development of hydrogen-barrier coatings that protect infrastructure from hydrogen embrittlement. These coatings are applicable in various contexts, including hydrogen fuel cell pipelines, storage tanks, and hydrogen-powered vehicles. By providing these innovative solutions, Arculus Solutions aims to help the energy industry mitigate risks associated with hydrogen transport, thereby improving overall safety and reliability in the sector.

Founded in 2011, Verdex Technologies specializes in the mass production of non-toxic nanofibers using proprietary green technology. The company designs, patents, and licenses equipment for filtration and biomedical purposes, creating advanced performance nanofiber materials for various applications such as engine filters, liquid filters, industrial air filters, waterproof textiles, medical packaging, and face masks.

Unspun, Inc. is a digital apparel company based in San Francisco, California, founded in 2015. It specializes in creating custom jeans tailored to individual consumers using advanced body scanning technology, fit algorithms, and additive manufacturing. The company aims to address environmental challenges by minimizing pattern-cutting waste and unsold inventory, thus contributing to a reduction in global carbon emissions. Unspun's innovative approach enables on-demand production of jeans in under ten minutes, utilizing localized manufacturing processes designed to be zero-waste. Its technology has gained recognition, including being named one of TIME's Best Inventions of 2019, and supports a B2B platform that facilitates digital customization for major apparel brands.

Founded in 2019, Karma Biotechnologies is a Los Angeles-based company dedicated to developing therapies for autoimmune diseases, allergies, and food sensitivities. It specializes in antigen-specific immunotherapies using lipid nanoparticle engineering.

California Cultured is a food company that uses cellular agriculture to produce cocoa and coffee, with the aim of delivering sustainable, lab-grown ingredients. Its cocoa is described as less bitter and requiring less sugar to achieve flavor, enabling premium quality products with a smaller environmental footprint. The company seeks to address social and environmental concerns linked to traditional cocoa production by avoiding practices such as slavery, deforestation, and child labor. California Cultured was founded in 2020 and is based in Davis, California.

VIA BioFuels is a biotechnology research company based in Houston, Texas, founded in 2023. The company specializes in the development of proprietary engineered yeast strains, specifically S. cerevisiae, which produce aromatic 3-methyl anisole (3-MA) from conventional ethanol feedstocks. VIA BioFuels’ technology is designed to be scalable, utilizing existing ethanol production methods and infrastructure. The high-purity 3-MA produced can be transformed into various valuable compounds, enhancing the market potential of the output and allowing consumers to substitute traditional fuels without blending restrictions.

Pannex Therapeutics is a New York-based biopharmaceutical company focused on developing innovative cancer therapies. It specializes in Pannexin 1 channel blockers, a novel class of drugs designed to inhibit multiple pathways, preventing cancer cell growth, metastasis, and survival.

Founded in 2023, AlkaLi Labs is a biotechnology company based in San Francisco. It specializes in recovering critical minerals like lithium and cobalt from industrial waste streams using bioengineering solutions.

Prime Roots is a plant-based food company that develops meat and seafood alternatives using koji mycelium-derived proteins. Its products include plant-based meats such as a salmon burger that mimic the taste, texture, and nutrition of animal-derived products. By leveraging natural koji proteins, Prime Roots aims to lower the environmental footprint of protein supply by reducing reliance on conventional animal farming, while offering protein-rich options for both meat eaters and vegetarians. Founded in 2017 and headquartered in San Francisco, Prime Roots operates in the food industry.

Pear Bio is a biotechnology company based in Boston and London. It develops precision medicine-guided therapeutics for hard-to-treat cancers using AI. The company analyzes tumor biopsies and blood to identify new targets, then tests drug candidates directly on patient samples using its proprietary immune-microtumor system.

Founded in 2023, League of Play is an interactive entertainment platform based in Los Angeles, California. It connects creators and athletes to produce engaging content with integrated e-commerce features.

Protogenix develops a platform technology to replace the mammalian cell system for manufacturing complex proteins. The decentralized plug-and-play platform enables high-yield production at greater speed and lower cost, helping food and pharmaceutical producers access sustainably produced, safe protein ingredients while aiming to reduce the carbon footprint of animal agriculture.

Geltor designs and produces animal-free collagen and other bioactive proteins for beauty, wellness, and nutrition applications. Founded in 2015, the company uses proprietary AI to create customized proteins tailored to specific industry needs.

Ten63 Therapeutics, Inc. is a biotechnology company based in Chapel Hill, North Carolina, focused on developing potent therapeutics for medically validated yet undruggable targets. Founded in 2017, the company utilizes its innovative platform, COPPER, which combines machine learning-based computational chemistry with advanced physical modeling to explore an extensive chemical space. This approach allows Ten63 Therapeutics to discover novel drug candidates for some of the most lethal diseases by employing proprietary algorithms for scaffold redesign and optimizing chemical design. By integrating these technologies, the company aims to produce durable therapies and improve drug resistance prediction, ultimately addressing challenges in drug development for previously intractable targets.

Amatec is an advanced materials company developing innovative construction solutions for the global housing and infrastructure sectors. Our flagship technology transforms industrial gypsum waste into fast-curing, high-strength, and low-carbon alternative concrete — enabling faster, greener, and more cost-effective construction. Amatec’s primary focus is on building a network of Microfactories: compact, modular production units capable of manufacturing high-quality precast housing panels and components. By leveraging phosphogypsum hemihydrate as a core raw material, Amatec helps industries repurpose mineral waste into sustainable building materials, significantly reducing environmental impact. Amatec's solutions are designed for scalability, automation, and rapid deployment, making them ideal for addressing major housing needs in the United States and elsewhere. The company is currently piloting its first microfactory and phosphogypsum processing lines in partnership with major industrial players.

MIMiC Systems designs solid-state heating and cooling systems at a building scale. It was founded in 2022 by Berardo Matalucci and Theodorian Borca-Tasciuc and is located in Brooklyn, New York.

Founded in 2015, Bite Inc. specializes in digital ordering solutions for the hospitality industry. Its primary offerings include bitekiosk, a kiosk ordering software for guests, and biteFLASH, a QR code-based mobile interface for contactless ordering.

Stämm Biotech is a San Francisco-based company specializing in advanced bioproduction systems designed to address the scaling challenges in the biotech industry. Founded in 2014, Stämm has developed an innovative biomanufacturing solution that integrates microfluidics, electroporation, and robotics, resulting in a compact, all-in-one Bioprocessor. This system has demonstrated productivity levels at least 70 times greater than traditional bioreactors, enabling clients to miniaturize bioreactors and optimize conditions more efficiently. Stämm's technology incorporates various sensors to monitor biological, physical, and chemical variations throughout the bioprocess, facilitating a streamlined approach to microbial growth and monoclonal cell line development. By transforming large-scale biotech operations into a more manageable micro-factory network, Stämm aims to unlock significant market potential in the coming years.

Hidden Gems is a beverage company that offers Reveal, a first and only avocado seed beverage. The company's mission is to create beautiful, environmentally safe, and socially responsible upcycled products by discovering the hidden value in the food people would normally call trash. Hidden gems aims to reduce food waste, continue to create and support sustainable systems for sustainable living. The company was founded in 2019 and is based in Philadelphia, Pennsylvania.

Pulse Industrial is a California-based company founded in 2017 that specializes in developing advanced monitoring solutions for industrial plants. The company focuses on creating sensors and devices that provide a comprehensive view of common valves and steam traps, which are critical components of steam generation processes. Pulse Industrial's flagship product, QALM, utilizes artificial intelligence to detect and monitor steam leaks by analyzing vibration and acoustic behavior. This innovative technology enables real-time alerts to maintenance personnel, facilitating timely interventions and enhancing operational safety. By leveraging low power wide area communication, Pulse Industrial's solutions aim to optimize energy efficiency and reduce fuel consumption across various industrial applications.

Windfall Bio is an innovative company based in San Mateo, California, that addresses climate change by transforming harmful methane emissions into organic fertilizer. Established in 2022, the company utilizes methane-eating microbes to capture methane from various sources, including agriculture, oil and gas, and waste management. This nature-based technology not only reduces the methane footprint of these industries but also improves their operational efficiency and profitability while minimizing the negative environmental impacts associated with synthetic fertilizers. By providing farmers and other producers with the means to convert methane into valuable soil nutrients, Windfall Bio fosters a sustainable agricultural future and contributes positively to environmental conservation. The company is backed by prominent venture capital firms, reflecting its potential to make a significant impact in the fight against climate change.

DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing innovative gene therapy treatments for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, the company utilizes advanced oral lipid nanoparticle technology to deliver mRNA and plasmid DNA directly to intestinal stem cells. This approach aims to address the root causes of gastrointestinal diseases, including Familial Adenomatous Polyposis (FAP), a hereditary condition that can lead to colorectal cancer and often necessitates invasive surgical interventions. DNALite's therapies seek to transform protein biologics into oral drugs, allowing for more effective and less invasive treatment options.

Pear Bio is a biotechnology company based in Boston and London. It develops precision medicine-guided therapeutics for hard-to-treat cancers using AI. The company analyzes tumor biopsies and blood to identify new targets, then tests drug candidates directly on patient samples using its proprietary immune-microtumor system.

Planetarians is a US-based Climate/FoodTech company developing affordable, healthy plant-based proteins through ingredient innovation. It focuses on an ingredient technology system that upcycles food by-products and solid waste into high-protein fiber ingredients, enabling the creation of alternative meat products and carbon-negative meat substitutes. Its processes repurpose spent soybeans from oil extraction and spent yeast from beer fermentation to produce natural protein and fiber that can fortify a range of foods. The company positions its technology to advance sustainable protein production and reduce waste while expanding plant-based options.

BiomeSense develops an integrated hardware, software, and data platform to scale microbiome data collection and analysis for clinical research. The company integrates at-home monitoring of the gut microbiome through its GutLab smart-bathroom system with the MetaBiome time-series analytics platform to connect microbiome changes with clinical outcomes in real time. Its platform supports large-scale, densely longitudinal datasets to discover, validate, and commercialize microbiome biomarkers, enabling clinicians to apply microbiome insights to improve human health. Founded in 2018 and based in Chicago, BiomeSense seeks to advance precision medicine by providing end-to-end microbiome measurement and analytics.

Atlantic Fish Company is focused on producing cultivated seafood through cellular agriculture, operating from its headquarters in Raleigh-Durham, North Carolina. The company aims to provide sustainable seafood options by cultivating fish in a controlled environment. This innovative approach allows Atlantic Fish Company to offer fresh fish meat that maintains the natural taste while minimizing the environmental impact associated with traditional fishing practices. By leveraging cellular agriculture, the company seeks to meet the growing demand for sustainable protein sources.

Tensorfield Agriculture is a company based in San Jose, California, specializing in the development and manufacture of advanced agricultural machinery tailored for specialty row crops. Founded in 2018, the company focuses on innovative solutions that promote sustainable farming practices in a post-herbicide environment. Tensorfield Agriculture's machinery includes robots equipped with computer vision technology that perform selective, non-invasive weeding through thermal micro-dosing techniques. This approach helps farmers combat herbicide resistance while ensuring the continued supply of safe and sustainable fresh food. The company's commitment to enhancing agricultural efficiency positions it at the forefront of modern farming solutions.

Lief Therapeutics is a medical device company based in San Francisco, California, focused on enhancing at-home care for individuals dealing with post-traumatic stress disorder, depression, and anxiety. The company has developed a discreet bio-sensing patch that accurately measures heart rate and breath, allowing users to manage their natural stress response through vibratory biofeedback exercises. This wearable device helps users monitor their behaviors, emotions, and thoughts in real-time, fostering mindfulness and control throughout the day. Additionally, it supports clinicians by tracking patient progress, facilitating in-session training, and scheduling psychological assessments. Lief Therapeutics also offers the Lief Health Score application, which records thoughts, emotions, and sensations, enabling users to track daily progress and engage in tailored exercises. Founded in 2014, the company sells its products online, aiming to empower individuals in their mental health journeys.

Tandem is a company that specializes in electrification solutions for heavy-duty vehicles, focusing on class 8 trucks. The company aims to revolutionize the supply chain by providing innovative hybrid electric refrigerated trailers that eliminate the upfront costs, risks, and infrastructure challenges associated with traditional electric drivetrains. With a commitment to enhancing sustainability in transportation, Tandem operates from offices located in New York and Florida.

BioCraft Pet Nutrition is a biotechnology company focused on creating sustainable and nutritious pet food for dogs and cats. Established in 2016 and based in Philadelphia, Pennsylvania, the company specializes in developing all-natural, organic products that incorporate innovative ingredients such as probiotics, nutritional yeast, and cultured meat. BioCraft aims to promote the health of pets while minimizing environmental impact and animal harm. The company's unique approach leverages green biotechnology to produce its offerings, which are available for purchase online. Through its commitment to sustainability and animal welfare, BioCraft Pet Nutrition stands out as a pioneer in the pet food industry.

Particle Industries, Inc. is a provider of a comprehensive platform designed for the prototyping, scaling, and management of Internet of Things (IoT) products. The company offers a range of hardware development kits, including the Photon for Wi-Fi projects and the Electron for cellular-connected devices, along with various accessories like antennas and USB shields. Particle also delivers software tools such as Tinker, a mobile application for remote control, and Particle Build, a web-based development environment that allows users to write and deploy code easily. Its cloud platform facilitates secure interactions with connected devices through modern APIs, supporting developers in creating intelligent web services. With over 150,000 product builders across more than 170 countries, including notable clients like NASA and SpaceX, Particle has established itself as a key player in the IoT landscape. Founded in 2012 and headquartered in San Francisco, California, with an additional office in Shenzhen, China, the company has been recognized for its innovation and impact in the IoT sector.

Founded in 2020, Prolific Machines is a San Francisco-based biotech company dedicated to revolutionizing cell production for a sustainable future. It combines advanced technologies to enable large-scale cell manufacturing, aiming to improve therapeutic protein production for biotechnology and pharmaceutical companies.

BioROSA Technologies Inc. is a biotechnology company focused on developing diagnostic tools for Autism Spectrum Disorders (ASD). Founded in 2018 and headquartered in Belmont, Massachusetts, the company specializes in creating biologically-based blood tests that assist clinicians in identifying individuals at risk for ASD. By utilizing machine learning to analyze biological data, BioROSA Technologies aims to provide reliable and accurate diagnoses, facilitating early detection and timely treatment. Additionally, the company's technology supports therapeutic trials by evaluating pharmacodynamics and patient stratification, thereby enhancing the overall standard of care for ASD.

Pneuma is a biotechnology company based in New York, USA. It develops sustainable products through innovative biological processes.

Harmony is a biotechnology startup that creates human breast milk protein-based infant nutrition designed to help human babies thrive. It is the world’s first dairy-free, allergen-free and environmentally friendly infant nutrition. Harmony Baby Nutrition was established in 2018 and is based in Boston, MA.

Renewell Energy develops gravity-based, renewable energy storage that repurposes idle oil and gas wells. The technology converts inactive wells into a low-cost, flexible storage network by lowering a weight down a repurposed wellbore to push electricity onto the grid when demand is high and raising it back up when demand is low, effectively storing energy as gravitational potential. The approach targets zero-self-discharge storage and aims to abate greenhouse gas emissions by utilizing existing oil and gas infrastructure to create a scalable energy storage solution. The company is based in Bakersfield, California.

OneSkin is a biotechnology company focused on skin aging and longevity that develops testing platforms and consumer products. It uses animal-free three-dimensional human skin models to evaluate the safety and efficacy of cosmetic ingredients and anti-aging compounds, supporting research and validation for the cosmetic and ingredient supplier industries. The company has developed a proprietary peptide, OS-01, intended to reduce skin biological age by decreasing the accumulation of aged cells, improving cellular repair, and strengthening the epidermal barrier. Its consumer offering includes a vegan topical product based on OS-01 designed for all skin types, marketed through its website. The business combines in vitro testing services with product development to address root causes of skin aging and support proper skin cell function.

Atlantic Fish Company is focused on producing cultivated seafood through cellular agriculture, operating from its headquarters in Raleigh-Durham, North Carolina. The company aims to provide sustainable seafood options by cultivating fish in a controlled environment. This innovative approach allows Atlantic Fish Company to offer fresh fish meat that maintains the natural taste while minimizing the environmental impact associated with traditional fishing practices. By leveraging cellular agriculture, the company seeks to meet the growing demand for sustainable protein sources.

Protogenix develops a platform technology to replace the mammalian cell system for manufacturing complex proteins. The decentralized plug-and-play platform enables high-yield production at greater speed and lower cost, helping food and pharmaceutical producers access sustainably produced, safe protein ingredients while aiming to reduce the carbon footprint of animal agriculture.

Founded in 2015, Looking Glass Factory develops and manufactures holographic displays designed for 3D creators. Its flagship product, the Looking Glass, combines light field and volumetric display technologies to enable users to create, share, and interact with 3D content without needing VR or AR headsets.

Helex is a biotechnology company developing genomic medicines for kidney-related diseases. It leverages its own genomics data, bioinformatics, and an intelligent data-driven platform to design, verify, and deliver therapy-specific gRNAs, with a focus on non-viral targeted delivery and genome editing for renal indications. The company's platform uses data-driven deep-learning models and high-throughput sequencing data from CRISPR edits in human cell lines to generate reliable predictions and validate them in-house. By combining these capabilities, Helex aims to accelerate CRISPR-based drug research and the development of cell and gene therapies for kidney conditions, offering precise and scalable renal therapeutics.

Terran Robotics is a construction company based in Bloomington, Indiana, that focuses on the integration of artificial intelligence and robotics in home construction. The company specializes in automated adobe wall building, utilizing a custom-designed cable-driven robot to create three-dimensional printed homes. This innovative approach enhances traditional earthen building techniques, offering features such as fire resistance and superior sound dampening. By leveraging advanced technology, Terran Robotics aims to significantly reduce housing costs, lower energy expenses, and promote environmentally friendly construction practices.

Michroma is a biotech company that develops natural, thermostable colorants for fungus-based food and cosmetics by leveraging fermentation of filamentous fungi and synthetic biology. It aims to replace synthetic pigments with natural pigments produced through biotechnological fermentation, delivering pH- and heat-stable colorants at scale for food and cosmetic applications. The company operates in multiple locations, including San Francisco, United States, and Rosario, Argentina, and pursues scalable production in bioreactors using proprietary fungal strains.

Gatehouse Bio is a biotech company based in Waltham, Massachusetts, founded in 2016. The company specializes in the development of therapies utilizing a novel bioinformatics platform that focuses on small ribonucleic acid (RNA) biomarkers. This platform is designed to classify patient samples with binary accuracy and identifies disease-associated mutations, enabling the creation of targeted therapeutics. By employing artificial intelligence, Gatehouse Bio aims to analyze small RNA genes and design oligonucleotides that can effectively counteract the effects of these mutations. Their research and development efforts target therapeutic areas with known heterogeneity, such as fibrosis, inflammation, and neurodegeneration, with the goal of unlocking the potential for improved patient outcomes through personalized medicine.

Founded in 2011, Verdex Technologies specializes in the mass production of non-toxic nanofibers using proprietary green technology. The company designs, patents, and licenses equipment for filtration and biomedical purposes, creating advanced performance nanofiber materials for various applications such as engine filters, liquid filters, industrial air filters, waterproof textiles, medical packaging, and face masks.