SOSV

Hoofprint Biome is a biotechnology company that develops probiotics and natural enzymes to enhance the sustainability of ruminant livestock production. Their products improve cattle health and digestive care by reducing methane emissions, thereby enabling the livestock industry to adopt more sustainable practices through microbiome engineering.

InnSight Technology is a biotechnology company focused on enhancing diagnostics and evaluation of eye diseases. The company develops innovative ophthalmic devices, including a novel hand-held biosensor designed for the detection of anterior ophthalmic injuries. Additionally, InnSight Technology works on advanced nanotechnology-based medical devices aimed at addressing specific clinical needs in ophthalmology. By providing these tools, the company seeks to improve ocular care for clinicians and their patients.

Sharper Sense is a company focused on wearable neurotechnology designed to enhance sensory acuity, including vision, hearing, and touch. The firm has developed a neuromodulation patch that employs comfortable, noninvasive electrical stimulation to improve sensory processing. This technology has both clinical and commercial applications, particularly in treating sensory processing disorders and sensory loss. By enhancing performance and safety, Sharper Sense aims to provide users with a clearer and more accurate perception of their surroundings.

Prellis Biologics, Inc. specializes in creating human tissues for drug development and the eventual production of human organs for transplantation. Founded in 2016 and based in San Francisco, California, the company employs advanced bioprinting technology to develop vascularized human tissues and organs, aiming to overcome the challenges associated with microvasculature. Its innovative products include TissueWorkshop, Organoids, Vascular Bundles, Tissue Chips, and Holograph X. Prellis Biologics also focuses on accurately replicating the human immune response through lymph node organoids, which can be utilized for various applications such as antibody discovery and immunogenicity assessment. By addressing critical issues in early-stage drug development and translational pharmacology, Prellis Biologics seeks to improve patient outcomes in healthcare.

Hoofprint Biome is a biotechnology company that develops probiotics and natural enzymes to enhance the sustainability of ruminant livestock production. Their products improve cattle health and digestive care by reducing methane emissions, thereby enabling the livestock industry to adopt more sustainable practices through microbiome engineering.

Aima Laboratories is a women's health healthcare company that provides innovative solutions to diagnostic and therapeutic difficulties. AIMA is working on the first non-invasive endometriosis diagnostic tool for the market. If you have chronic pelvic/period pain or are having difficulty becoming pregnant, you may have endometriosis.

Ria Health is an online platform that provides telehealth services for individuals looking to improve their relationship with alcohol. It offers personalized treatment plans that include medication-assisted treatment options and behavioral therapies, all supported by licensed healthcare professionals. The platform emphasizes continuous monitoring to help users track their progress and maintain accountability in their recovery journey. Ria Health features a mobile app that grants users access to educational materials, support groups, and direct communication with care teams. This comprehensive approach aims to assist individuals in managing alcohol consumption and fostering healthier habits.

Ostoform Limited is a medical device company based in Dublin, Ireland, focused on improving skin health for individuals with ostomies. Founded in 2016 as a spin-out from the University of Limerick, Ostoform develops patented technologies aimed at managing and reducing skin complications associated with ostomies. The company's primary products include a mouldable seal that fits securely around the stoma and FLOWASSIST, which directs stoma output away from the skin. By effectively guiding the corrosive output into the ostomy bag, these products help prevent skin irritation and swelling, enhancing patient comfort and quality of life. Ostoform aims to become a global leader in the ostomy skin health market, leveraging its innovative solutions to address the needs of ostomy patients.

Particella specializes in the development of innovative lipid nanoparticle technology designed for the oral delivery of mRNA and other nucleic acids. This proprietary approach aims to transform the way biological medicines are administered by utilizing the intestinal tract to secrete proteins into the bloodstream, effectively allowing for the conversion of protein biologics into oral drugs. The company’s technology seeks to address existing limitations in the delivery of biological medicines, presenting potential advancements in preventing gastrointestinal diseases in patients.

RyboDyn is a biotechnology research company focused on developing innovative therapeutics aimed at training the immune system to detect and eliminate cancer from within the body. The company is dedicated to advancing scientific breakthroughs that lead to new classes of treatments, providing significant improvements in medicine. RyboDyn's work is particularly concentrated on creating upgraded therapies for serious diseases, including terminal conditions, with the goal of enhancing patient outcomes and expanding treatment options.

Proton Intelligence is a Canadian company, founded in 2020 and based in Vancouver, that specializes in biomarker monitoring to assist in managing chronic diseases and improving patient outcomes. The company has developed a wearable continuous potassium monitoring platform aimed at individuals with hyperkalemia, particularly those suffering from chronic kidney disease and other co-morbidities. By providing accurate and real-time potassium measurements through interstitial fluid analysis, Proton Intelligence facilitates critical health monitoring for both clinicians and patients. This technology enables informed decision-making regarding medications, diet, and treatment options, thereby enhancing the management of hyperkalemia and promoting better overall health for affected individuals.

Serene Sleep is a medical technology company that focuses on improving sleep quality by addressing snoring and sleep apnea. It develops and offers a non-invasive, targeted treatment procedure using palatal implants, designed to reduce disruptive snoring and enhance overall sleep for both the individual and their partner.

Seismi is a veterinary healthcare company specializing in non-invasive, continuous monitoring solutions for pets. Their platform tracks vital signs such as heart rate, respiration, and blood pressure, providing pet owners with real-time, reliable health data, and reducing stress for both pets and owners. Additionally, Seismi offers cattle sensor technology and methane emission analytics, contributing to livestock health management and environmental sustainability.

Ten63 Therapeutics is a biotechnology company focused on developing innovative therapeutics for challenging diseases, particularly those involving targets previously considered undruggable. Founded in 2017 and based in Chapel Hill, North Carolina, the company utilizes its proprietary platform, COPPER, which integrates advanced artificial intelligence and state-of-the-art physical models to explore vast chemical spaces. By employing low-residual, machine learning-based computational chemistry alongside superlinear search algorithms, Ten63 Therapeutics aims to identify and optimize drug candidates effectively. Their approach includes proprietary scaffold redesign and hopping technology, enabling the screening of trillions of molecules to predict resistance and redesign antibodies. This combination of techniques positions Ten63 Therapeutics at the forefront of developing durable treatments for some of the most lethal diseases.

Samphire Neuroscience is a neurotechnology company based in London, England, founded in 2021. The company focuses on women's health and lifestyle enhancement through innovative solutions. Its primary product is a headband device that employs non-invasive electrical neuromodulation to stimulate specific areas of the brain. This technology aims to alleviate symptoms commonly associated with menstrual cycles, including pain, fatigue, and mood disturbances, thereby improving the overall well-being of women.

BioSapien is a pre-clinical biotechnology company focused on creating innovative biodegradable implantable products for oncology applications. The company is developing a 3D-printed drug delivery platform that utilizes a biodegradable mesh to deliver active pharmaceutical ingredients (APIs) directly to tumor sites, thereby minimizing systemic side effects associated with traditional therapies. Their flagship product, the MediChip, is designed to administer FDA-approved high-dose systemic therapies in a localized and sustained manner, enhancing the quality of patient care. Current research is focused on applications for pancreatic and lung cancers, with plans to expand the pipeline to include other types such as colorectal, breast, and stomach cancers. By targeting drug delivery directly to cancerous tissues, BioSapien aims to improve treatment efficacy while reducing toxicity for patients.

BioLattice is a biotechnology company focused on developing tissue-engineered cornea technology. Their primary goal is to provide a viable alternative to donor tissue for full-thickness corneal transplants. The company's innovative technology offers a corneal prototype with vision-correcting capabilities, aiming to restore sight for patients requiring corneal transplants.

Vitarka Therapeutics is a London-based company focused on developing medical technologies and solutions for various types of cancer. The company has created a targeted non-viral delivery platform aimed at intracellular targets in oncology, neuroscience, and neurodegeneration. This innovative platform works by activating the immune system and normalizing tumor vasculature, significantly improving outcomes for late-stage patients suffering from lung, colon, breast, and other cancers. By utilizing re-engineered pore-forming proteins for cell-specific targeting and facilitating the endosomal release of therapeutic cargo, Vitarka Therapeutics aims to provide cancer patients with renewed hope and the potential to lead more normal lives.

Medical Devices, Kidney Disease, Wearables, Medtech, Hardtech

Machine Medicine Technologies Ltd, established in 2017 and based in London, UK, specializes in developing artificial intelligence-driven solutions for healthcare. The company's core product, KELVIN-PD, employs computer vision and pose estimation to objectively measure and analyze movement in patients, particularly those with Parkinson's disease. This platform delivers precise metrics, such as tremor and bradykinesia, from simple video clips, enabling secure, device-agnostic, and affordable patient data management.

VIAN Therapeutics is an early-stage biotechnology company dedicated to innovating treatments for retinal diseases. The company is developing a first-in-class, non-invasive eyedrop intended to replace traditional injections for conditions such as age-related macular degeneration and diabetic macular edema. With robust preclinical data and ongoing clinical trials, VIAN aims to meet significant unmet medical needs in the retinal disease market, which is valued at $15 billion. Additionally, the company is engaged in the creation of peptide drugs that enhance efficacy and safety for treating both ophthalmic and oncology-related conditions by targeting angiogenesis, thereby offering patients improved health outcomes.

Exosomm is an innovative foodtech start-up focused on developing nutritional solutions derived from natural milk exosomes. The company was founded based on research from Hadassah Medical Center, led by Prof. Reif's team. Exosomm's flagship product is a specialized food formula designed for patients suffering from inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. This product utilizes a patented active anti-inflammatory ingredient sourced from milk exosomes, which are isolated using a natural and environmentally friendly process. By targeting health and immunity, Exosomm aims to provide effective solutions for individuals with specific dietary needs.

Laguna Bio is a biotechnology company based in Berkeley, California, founded in 2022. The company focuses on drug discovery, specifically developing a platform that activates and expands the innate immune system to combat cancer. Laguna Bio specializes in enhancing a specific type of T cell that targets solid tumors, aiming to improve the efficacy of bispecific antibody drugs. By increasing the immune response against these tumors, the company seeks to provide innovative solutions that may help patients survive cancer more effectively.

FREZENT is a biotechnology company focused on developing innovative therapeutics for advanced-stage cancer patients. It specializes in creating biological inhibitors that target cancer-specific lipid metabolism, aiming to prevent the reactivation of dormant cancer cells.

DisperseBio is a Biotechnology Research firm developing a mechanism to counter microbial contamination on natural surfaces like human body.

Metabolic Psychiatry Labs is a mental healthcare company that provides remote treatment solutions for mental illnesses. Their platform integrates metabolic and mental health research, data tracking, metabolic interventions, and personalized medical care, enabling patients to receive effective treatments from home. The company offers assessments, lab tests, and wellness solutions based on metabolic therapy.

Gatehouse Bio is a biotechnology company based in Waltham, Massachusetts, focused on the accelerated development of therapies utilizing small ribonucleic acid (RNA) and advanced bioinformatics. Founded in 2016, the company has developed a platform that employs artificial intelligence to identify error-free RNA biomarkers and discover disease-associated mutations. This platform enables precise classification of patient samples, which aids in the design of targeted therapeutics aimed at addressing various diseases, particularly in areas characterized by known heterogeneity such as fibrosis, inflammation, and neurodegeneration. By analyzing small RNA genes, Gatehouse Bio aims to unlock the potential for innovative treatments that could significantly enhance patient outcomes.

Minutia is focused on developing innovative solutions for Type 1 Diabetes through stem cell-derived transplants that incorporate nanosensors. The company specializes in creating subcutaneous insulin-producing cell transplants that are immune-evasive and capable of real-time monitoring via proprietary cell-based sensors. This approach aims to address common challenges associated with transplants and seeks to provide a functional cure for diabetes. By advancing both transplantation techniques and monitoring capabilities, Minutia aspires to transform the clinical landscape of diabetes management and cell replacement therapies.

Calyx develops advanced sensor platforms that monitor various parameters in poultry and livestock, utilizing cutting-edge technology to address complex challenges in the industry. The company specializes in gas sensor technology that detects airborne chemical emissions through innovative sensors patterned with viruses that bind to specific gas molecules. These sensors provide high specificity and sensitivity, changing color in response to different gases and their concentrations. By integrating artificial intelligence, computer vision technology, and data science, Calyx aims to enhance environmental monitoring and improve health outcomes for livestock and poultry, offering commercial customers effective solutions to track daily environmental changes.

Asta Bio is a biotechnology company specializing in the development of radiotherapeutics for cancer treatment. It focuses on combining the alpha-emitting radioisotope 211-Astatine with multivalent single-domain antibodies to deliver targeted alpha radiation to tumor cells, sparing healthy cells. This approach aims to effectively destroy cancer cells by breaking their DNA strands.

Bloomlife is a women's health company focused on addressing critical challenges in maternal health through an innovative remote care platform. By integrating connected devices with cloud-based data analytics, Bloomlife enhances access to care and empowers expectant mothers while providing clinicians with essential information to better screen and manage pregnancy complications. The company's prenatal wearable technology is designed to assess fetal health, enabling the identification of potential complications that could lead to serious outcomes such as brain damage or stillbirth. This approach marks a significant departure from traditional methods of managing high-risk pregnancies, which often involve frequent in-person appointments and lengthy referral processes. Bloomlife aims to be a leader in remote maternal care, facilitating timely interventions and support for women, regardless of geographic barriers.

Tinkeso Therapeutics is a biotechnology company specializing in the development of innovative cell therapies for treating cancer and autoimmune diseases. The company focuses on creating off-the-shelf, allogeneic chimeric antigen receptor (CAR) engineered natural killer T (NKT) cell therapies. These therapies use NKT cells to target and destroy cancer cells or modulate the immune response in autoimmune conditions, aiming to increase treatment accessibility and scalability.

heXem bio specializes in recording solutions for the early development of humans for longevity.

Zhenshi Medical is a medical device company that specializes in lung puncture medical robots for diagnosing and treating lung cancer.

CroiValve Limited, founded in 2016 and based in Dublin, Ireland, specializes in the development of a medical device aimed at treating severe tricuspid regurgitation through a minimally invasive procedure. The company's innovative device allows for percutaneous delivery via a vein into the right heart, effectively sealing the gap between the native tricuspid valve leaflets. This approach restores proper valve function and prevents regurgitation, enabling healthcare professionals to address this condition in a safe, effective, and cost-efficient manner. CroiValve's solution is designed to be user-friendly, catering to a broad range of patients suffering from this serious heart issue.

DeepSpin GmbH, founded in 2019 and based in Berlin, Germany, specializes in developing artificial intelligence-powered magnetic resonance imaging (MRI) equipment. The company’s innovative technology aims to provide MRI imaging systems that are significantly smaller, lighter, and more cost-effective than traditional models. By leveraging generative topological design and deep learning techniques, DeepSpin's MRI machines enhance accessibility to medical imaging, making it available to a wider range of patients globally. This approach seeks to improve healthcare standards in various medical fields previously lacking adequate imaging solutions.

Aima Laboratories is a women's health healthcare company that provides innovative solutions to diagnostic and therapeutic difficulties. AIMA is working on the first non-invasive endometriosis diagnostic tool for the market. If you have chronic pelvic/period pain or are having difficulty becoming pregnant, you may have endometriosis.

Flow Neuroscience, established in 2011 and based in Malmö, Sweden, specializes in developing and manufacturing a wearable device and accompanying mobile application for medication-free treatment of depression. The company's core product is a transcranial direct current stimulation (tDCS) headset that targets the left frontal lobe, an area of the brain often associated with depression. This non-invasive treatment is complemented by a personalized mobile app that encourages users to adopt healthier daily routines, such as regular exercise and sleep patterns, to help alleviate depressive symptoms. Flow Neuroscience aims to make this innovative, affordable treatment accessible to the public, challenging the dominance of pharmaceuticals in mental health care.

Kegg is a fertility tracking device that combines the functions of monitoring vaginal fluid and facilitating pelvic floor exercises. Founded in 2017 and based in San Francisco, California, Kegg utilizes advanced sensing technology to detect changes in cervical fluid, thereby enabling women to identify their fertile window and ovulation up to seven days in advance. This innovative approach provides essential data that enhances the diagnosis, monitoring, and treatment of women's reproductive health, significantly increasing the chances of natural conception. By offering an intuitive and effective solution, Kegg empowers women with the information they need to make informed decisions regarding their fertility.

VIAN Therapeutics is an early-stage biotechnology company dedicated to innovating treatments for retinal diseases. The company is developing a first-in-class, non-invasive eyedrop intended to replace traditional injections for conditions such as age-related macular degeneration and diabetic macular edema. With robust preclinical data and ongoing clinical trials, VIAN aims to meet significant unmet medical needs in the retinal disease market, which is valued at $15 billion. Additionally, the company is engaged in the creation of peptide drugs that enhance efficacy and safety for treating both ophthalmic and oncology-related conditions by targeting angiogenesis, thereby offering patients improved health outcomes.

OncoPrecision is a company that focuses on improving cancer therapy outcomes by utilizing a patient micro avatar platform. This innovative platform employs single-cell high-throughput biology and machine learning to generate comprehensive patient-derived phenotypic biomarkers. By doing so, it enables oncologists to make informed, data-driven decisions regarding the selection of cancer therapies tailored to individual patients. The approach aims to increase the success rates of cancer treatments by ensuring that the right therapy is matched to the right patient, thus enhancing overall patient care and treatment effectiveness.

GlowDx is a diagnostics company based in Midleton, Ireland, established in 2015. The company focuses on decentralizing molecular testing through innovative point-of-care technologies, which facilitate local access to diagnostics for tropical diseases. By combining novel molecular technology with effective delivery models, GlowDx aims to improve clinical outcomes while reducing the economic burden on patients and healthcare systems. This approach enhances the quality of life for individuals by ensuring they receive timely and accurate diagnostic information, thereby enabling healthcare providers to offer better-targeted treatments.

FeetMe is a digital health company specializing in advanced technology for gait and activity assessments in both clinical and real-world settings. The company develops innovative wearable products, particularly smart insoles equipped with pressure sensors and motion analysis algorithms. These products enable real-time monitoring of patients' mobility and posture, facilitating comprehensive evaluations of movement disorders and mobility constraints. By providing relevant digital biomarkers, FeetMe aims to support clinical research and enhance patient care, allowing healthcare professionals to track disease progression, improve functional outcomes, and optimize treatment strategies.

VisusNano Ltd. is a pre-clinical company based in London, United Kingdom, focused on developing a drug-eluting intraocular lens implant for cataract surgery. Founded in 2016, the company aims to enhance patient outcomes by reducing the risks associated with cataract procedures, such as intraocular inflammation, infection, and opacification. This innovative lens technology eliminates the need for postoperative eye drops and laser treatments, positioning it as a potential game-changer in both human and veterinary cataract surgery markets. Through its advancements, VisusNano seeks to revolutionize the standard of care in ophthalmic procedures.

Lief Therapeutics is a medical device company focused on improving at-home care for individuals suffering from post-traumatic stress disorder, depression, and anxiety. The company has developed a discreet biosensing patch that measures heart rate and breathing patterns with medical accuracy. This wearable device, known as Lief, helps users manage their stress responses through biofeedback exercises, allowing them to monitor their emotions and behaviors in real-time. Additionally, the device provides clinicians with insights into patient progress, enabling in-session training and tracking of psychological assessments. Lief Therapeutics also offers the Lief Health Score application, which records thoughts, emotions, and sensations, facilitating the tracking of daily progress and personalized practice exercises. Founded in 2014 and based in San Francisco, California, the company sells its products online.

CroiValve Limited, founded in 2016 and based in Dublin, Ireland, specializes in the development of a medical device aimed at treating severe tricuspid regurgitation through a minimally invasive procedure. The company's innovative device allows for percutaneous delivery via a vein into the right heart, effectively sealing the gap between the native tricuspid valve leaflets. This approach restores proper valve function and prevents regurgitation, enabling healthcare professionals to address this condition in a safe, effective, and cost-efficient manner. CroiValve's solution is designed to be user-friendly, catering to a broad range of patients suffering from this serious heart issue.

Helex, founded in 2021 and based in New York, specializes in developing innovative genomic medicines specifically for renal conditions. The company leverages its proprietary genomics data and bioinformatics platform to create, verify, and distribute therapy-specific guide RNAs (gRNAs). By employing data-driven deep-learning models and high throughput next-generation sequencing data from CRISPR edits on human cell lines, Helex provides reliable predictions and validations in-house. This approach supports clients in expediting the development of CRISPR-based drug discovery and cell and gene therapies, emphasizing non-viral targeted delivery and genome editing for kidney-related therapies.

Flashaid operates a health-tech platform designed to enhance the hospitalization experience for patients and healthcare providers. This platform connects patients and hospitals with various stakeholders, streamlining the process of hospital e-admission, treatment financing, service payments, and insurance information. By consolidating these services into a single interface, Flashaid allows hospitals to automate front-office operations, ultimately improving patient care and maximizing revenue potential. The technology aims to simplify and optimize the overall experience of hospitalization for all parties involved.

Calder Biosciences is focused on developing next-generation vaccines to address significant public health challenges posed by evolving viruses. Their innovative 3D-Vaxlock technology enhances vaccine stability and efficacy by creating molecular structures that maintain the most effective shapes of immunogens. This approach aims to improve protection against respiratory syncytial virus (RSV), particularly for the elderly, and to create a universal flu vaccine effective against all seasonal strains. By addressing the limitations of traditional vaccine designs, Calder aims to deliver solutions that provide better safety, durability, and effectiveness for at-risk populations. Ultimately, their goal is to prevent severe illnesses and reduce the healthcare burden, contributing to healthier lives for billions of people.

Cell BioEngines, Inc. is a clinical-stage biotechnology company dedicated to the development of allogeneic "off-the-shelf" stem cell therapies for the treatment of various human diseases, with a particular focus on oncology. The company has created a blood stem cell-derived epigenetic platform designed to address challenges related to donor source availability, cellular potency, and the complexities of manufacturing clinical-grade cell products. By leveraging this innovative platform, Cell BioEngines aims to produce cell-based therapies that can provide long-lasting benefits to patients, ultimately striving to transform cancer into a curable disease.

Cayuga Biotech is a startup focused on developing innovative hemostatic drugs and devices aimed at reducing uncontrollable bleeding, a leading cause of death from traumatic injuries. The company utilizes a polyphosphate-based drug that enhances the body's natural clotting ability, effectively promoting clot formation at injury sites while minimizing potential side effects. Cayuga's product pipeline includes a clinic-ready drug for life-threatening bleeding and therapeutics in the discovery stage for rare inherited bleeding disorders, central nervous system bleeding, severe burns, and non-healing wounds. By harnessing the body's innate coagulation response, Cayuga Biotech aims to improve survival rates and reduce disability associated with trauma.

Strados Labs, LLC is a medical technology company based in Philadelphia, Pennsylvania, that focuses on innovating respiratory health management through advanced biosensors and artificial intelligence. Founded in 2016, Strados Labs develops a wearable device that provides real-time insights into respiratory metrics such as breathing speed, sounds, and patterns. This device is equipped with a continuous breathing sensor that enables remote monitoring of patients with respiratory conditions like asthma and chronic obstructive pulmonary disease. By connecting the device to a mobile application, patients and healthcare providers can access critical respiratory data, facilitating informed decision-making and improved management of respiratory health.

Samphire Neuroscience is a neurotechnology company based in London, England, founded in 2021. The company focuses on women's health and lifestyle enhancement through innovative solutions. Its primary product is a headband device that employs non-invasive electrical neuromodulation to stimulate specific areas of the brain. This technology aims to alleviate symptoms commonly associated with menstrual cycles, including pain, fatigue, and mood disturbances, thereby improving the overall well-being of women.

XN Health is a medical device company based in Texas, founded in 2021. The company specializes in developing healthcare devices aimed at improving the process of mechanical ventilation. Its innovative technology focuses on phrenic nerve stimulation, which induces diaphragm contractions during ventilation. This approach helps protect against diaphragm dysfunction in patients who are mechanically ventilated, ultimately enabling them to wean off the ventilator more quickly and safely.

Feel Therapeutics is a digital precision medicine company focused on improving mental health through objective data and passive monitoring. It develops physiological and digital biomarkers alongside therapeutics that aid in the diagnosis, management, and care of mental health conditions. The company's platform includes proprietary medical-grade wearables, such as a wristband equipped with five embedded sensors, which collect biometric data. This data is analyzed using advanced computational methods to create digital biomarkers. By integrating these technologies, Feel Therapeutics aims to provide users with evidence-based insights that enhance their mental well-being and foster the development of lasting positive emotional habits.

Chronus Health, Inc. is a company that specializes in developing a portable diagnostic platform aimed at delivering rapid point-of-care lab results, specifically for complete blood count and comprehensive metabolic panel tests. Founded in 2017 and based in Mountain View, California, the company's innovative system utilizes microfluidics and semiconductor technology, combined with data analytics, to provide healthcare providers with real-time test results. This capability allows for immediate diagnosis at the point of care, enhancing the efficiency of treatment and significantly improving patient outcomes. By enabling doctors to obtain lab results in minutes, Chronus Health facilitates timely decision-making in clinical settings.

Verdex Technologies Inc. is a company based in North Chesterfield, Virginia, that specializes in the design, patenting, and licensing of non-toxic nanofiber producing equipment for various applications, particularly in filtration and biomedical fields. The company leverages proprietary technology to mass produce advanced nanofibers, enabling the creation of high-quality nonwoven materials suitable for a wide range of uses, including engine filters, liquid filters, industrial air filters, and medical packaging. Verdex's innovative approach allows for the functionalization of nanofibers by incorporating nano-sized ingredients, enhancing the effectiveness of products like water filters. Committed to sustainability, Verdex utilizes biodegradable and bioresorbable polymers in its processes, ensuring that its production methods are environmentally friendly. Founded in 2011, the company aims to unlock the potential of nanofibers and improve quality of life through its advanced materials.

Lura Health has developed a groundbreaking non-invasive health monitoring platform that utilizes saliva as a diagnostic fluid, aiming to enhance clinical outcomes in chronic disease management. Founded in 2017 and based in Cambridge, Massachusetts, the company targets various chronic disease markets, including heart disease, chronic kidney disease, diabetes, and tooth decay. Its innovative sensors are integrated into patient-friendly orthodontic devices such as removable retainers and fixed braces. These sensors continuously measure analytes in saliva and automatically transmit data to a smartphone application, allowing users to track key diagnostic metrics related to their oral health. By enabling individuals to monitor their health in real-time, Lura Health seeks to improve personal health management and empower users to take charge of their well-being.

RyboDyn is a biotechnology research company focused on developing innovative therapeutics aimed at training the immune system to detect and eliminate cancer from within the body. The company is dedicated to advancing scientific breakthroughs that lead to new classes of treatments, providing significant improvements in medicine. RyboDyn's work is particularly concentrated on creating upgraded therapies for serious diseases, including terminal conditions, with the goal of enhancing patient outcomes and expanding treatment options.

Prellis Biologics, Inc. specializes in creating human tissues for drug development and the eventual production of human organs for transplantation. Founded in 2016 and based in San Francisco, California, the company employs advanced bioprinting technology to develop vascularized human tissues and organs, aiming to overcome the challenges associated with microvasculature. Its innovative products include TissueWorkshop, Organoids, Vascular Bundles, Tissue Chips, and Holograph X. Prellis Biologics also focuses on accurately replicating the human immune response through lymph node organoids, which can be utilized for various applications such as antibody discovery and immunogenicity assessment. By addressing critical issues in early-stage drug development and translational pharmacology, Prellis Biologics seeks to improve patient outcomes in healthcare.

Hypercell Technologies focuses on developing innovative diagnostic tools and monoclonal antibodies aimed at controlling infectious diseases in animals. The company employs molecular biology techniques to create accurate in-farm diagnostic tools that deliver results in under one hour. This rapid testing capability, combined with their antibodies, allows veterinarians to effectively manage and mitigate the spread of viruses within production animal populations. Hypercell Technologies is committed to preventing potential pandemics in humans by addressing the root causes of infectious diseases in animal reservoirs.

Optimize Health is a digital healthcare provider specializing in remote patient monitoring (RPM) solutions. The company offers a user-friendly platform that incorporates both equipment and software designed to streamline the implementation of RPM programs. Its software aids healthcare providers in complying with Medicare billing requirements for RPM services while ensuring a positive experience for both patients and providers. The platform automatically tracks medication doses and sends reminders to users, leveraging Bluetooth technology to sync with smartphones and tablets. This approach empowers patients to manage their health effectively and enables physicians to achieve profitability from RPM services starting in the first month.

FluidAI Medical is a company dedicated to enhancing patient care through innovative technology in post-operative recovery. It has developed a smart catheter system that employs artificial intelligence to monitor patients' health data within the body. This proactive approach enables the early detection of postoperative complications, allowing healthcare providers to access critical health information promptly. By leveraging data-driven insights, FluidAI aims to improve recovery outcomes and transform the standards of post-operative care.

Rizlab Health is a medical device startup founded in 2018 and based in East Princeton. The company specializes in providing practitioners and patients with rapid blood count readings, specifically focusing on white blood cell analysis. Rizlab Health's electronic cytometer and analyzer utilize a cartridge system to quantify key cellular components, such as neutrophils and lymphocytes. This technology enables hospitals and healthcare providers to quickly and affordably monitor patients' white blood counts, which is crucial for diagnosing conditions like sepsis and distinguishing between bacterial and viral infections. By offering a fast, portable, and cost-effective health monitoring solution, Rizlab Health aims to enhance patient care and streamline clinical decision-making processes.

BioAesthetics LLC, founded in 2015 as a spin-out from Tulane University, is focused on developing innovative reconstruction options for breast cancer patients following mastectomies. The company specializes in a tissue-engineered nipple-areolar complex (NAC) that serves as an acellular graft to be used by plastic and reconstructive surgeons during the breast reconstruction phase. This product allows the patient's own cells to integrate with the graft, facilitating the regeneration of a natural nipple and areola. Currently in the pre-clinical phase, this patent-pending technology aims to provide a more effective and aesthetically pleasing solution for patients who have experienced incomplete or removed NACs due to illness, surgery, or congenital conditions. BioAesthetics is headquartered in Research Triangle Park, North Carolina.

FREZENT is a biotechnology company focused on developing innovative therapeutics for advanced-stage cancer patients. It specializes in creating biological inhibitors that target cancer-specific lipid metabolism, aiming to prevent the reactivation of dormant cancer cells.

Medical Devices, Kidney Disease, Wearables, Medtech, Hardtech

Gatehouse Bio is a biotechnology company based in Waltham, Massachusetts, focused on the accelerated development of therapies utilizing small ribonucleic acid (RNA) and advanced bioinformatics. Founded in 2016, the company has developed a platform that employs artificial intelligence to identify error-free RNA biomarkers and discover disease-associated mutations. This platform enables precise classification of patient samples, which aids in the design of targeted therapeutics aimed at addressing various diseases, particularly in areas characterized by known heterogeneity such as fibrosis, inflammation, and neurodegeneration. By analyzing small RNA genes, Gatehouse Bio aims to unlock the potential for innovative treatments that could significantly enhance patient outcomes.

Calder Biosciences is focused on developing next-generation vaccines to address significant public health challenges posed by evolving viruses. Their innovative 3D-Vaxlock technology enhances vaccine stability and efficacy by creating molecular structures that maintain the most effective shapes of immunogens. This approach aims to improve protection against respiratory syncytial virus (RSV), particularly for the elderly, and to create a universal flu vaccine effective against all seasonal strains. By addressing the limitations of traditional vaccine designs, Calder aims to deliver solutions that provide better safety, durability, and effectiveness for at-risk populations. Ultimately, their goal is to prevent severe illnesses and reduce the healthcare burden, contributing to healthier lives for billions of people.

Xias Bio is a biotechnology startup focused on producing recombinant proteins that enhance the delivery of functional ingredients for various sectors, including research, beauty, and healthcare. The company specializes in developing non-immunogenic natural motifs, which provide a superior platform for creating soluble and active ingredients with desirable properties such as improved gel and film formation and antioxidant effects. By offering an adaptable, animal product-free biomaterial, Xias Bio delivers tailored biological functionalities that outperform traditional synthetic and animal-based products. This innovation enables pharmaceutical and cosmetic companies to access non-toxic, non-immunogenic alternatives for a wide range of applications.

MedIQ is an integrated virtual care platform providing on-demand healthcare at the point of need. MedIQ redefines healthcare through a digitally enabled, cashless, hybrid healthcare ecosystem. MedIQ makes high-quality, modernized healthcare and wellness available to everyone.

QuantumCyte, Inc. is a technology platform company based in Sunnyvale, California, that specializes in cell analysis systems aimed at predicting drug efficacy and improving cancer treatment outcomes. Founded in 2014, QuantumCyte develops automated microdissection solutions for molecular pathology, utilizing digital tissue maps to isolate regions of interest that contain important biomarkers. By harnessing artificial intelligence in digital pathology, the company enables healthcare providers to perform precise single-cell analysis, enhancing the understanding of immune system and cancer biology.

Cell BioEngines, Inc. is a clinical-stage biotechnology company dedicated to the development of allogeneic "off-the-shelf" stem cell therapies for the treatment of various human diseases, with a particular focus on oncology. The company has created a blood stem cell-derived epigenetic platform designed to address challenges related to donor source availability, cellular potency, and the complexities of manufacturing clinical-grade cell products. By leveraging this innovative platform, Cell BioEngines aims to produce cell-based therapies that can provide long-lasting benefits to patients, ultimately striving to transform cancer into a curable disease.

Lios, originally founded as Restored Hearing in 2009 by Rhona Togher and Eimear O’Carroll, focuses on combating noise pollution through innovative materials and technologies. The company specializes in developing solutions that reduce the risk of exposure to loud noise and mitigate damage from it. Its flagship product, SoundBounce, is a revolutionary acoustic material designed for various industries, including automotive, aerospace, construction, and power generation. SoundBounce is notably thinner and more effective than traditional soundproofing materials. Additionally, Lios offers SoundRelief, a tinnitus sound therapy app available on both Apple and Android platforms, which provides at-home treatment for ringing in the ears. The app, scientifically validated and CE marked, includes features for tracking tinnitus and has been utilized in over 60 countries, significantly improving users' quality of life. Through these innovations, Lios addresses industry challenges with a commitment to creating a quieter world.

Feel Therapeutics is a digital precision medicine company focused on improving mental health through objective data and passive monitoring. It develops physiological and digital biomarkers alongside therapeutics that aid in the diagnosis, management, and care of mental health conditions. The company's platform includes proprietary medical-grade wearables, such as a wristband equipped with five embedded sensors, which collect biometric data. This data is analyzed using advanced computational methods to create digital biomarkers. By integrating these technologies, Feel Therapeutics aims to provide users with evidence-based insights that enhance their mental well-being and foster the development of lasting positive emotional habits.

BioSapien is a pre-clinical biotechnology company focused on creating innovative biodegradable implantable products for oncology applications. The company is developing a 3D-printed drug delivery platform that utilizes a biodegradable mesh to deliver active pharmaceutical ingredients (APIs) directly to tumor sites, thereby minimizing systemic side effects associated with traditional therapies. Their flagship product, the MediChip, is designed to administer FDA-approved high-dose systemic therapies in a localized and sustained manner, enhancing the quality of patient care. Current research is focused on applications for pancreatic and lung cancers, with plans to expand the pipeline to include other types such as colorectal, breast, and stomach cancers. By targeting drug delivery directly to cancerous tissues, BioSapien aims to improve treatment efficacy while reducing toxicity for patients.

CroiValve Limited, founded in 2016 and based in Dublin, Ireland, specializes in the development of a medical device aimed at treating severe tricuspid regurgitation through a minimally invasive procedure. The company's innovative device allows for percutaneous delivery via a vein into the right heart, effectively sealing the gap between the native tricuspid valve leaflets. This approach restores proper valve function and prevents regurgitation, enabling healthcare professionals to address this condition in a safe, effective, and cost-efficient manner. CroiValve's solution is designed to be user-friendly, catering to a broad range of patients suffering from this serious heart issue.

Verdex Technologies Inc. is a company based in North Chesterfield, Virginia, that specializes in the design, patenting, and licensing of non-toxic nanofiber producing equipment for various applications, particularly in filtration and biomedical fields. The company leverages proprietary technology to mass produce advanced nanofibers, enabling the creation of high-quality nonwoven materials suitable for a wide range of uses, including engine filters, liquid filters, industrial air filters, and medical packaging. Verdex's innovative approach allows for the functionalization of nanofibers by incorporating nano-sized ingredients, enhancing the effectiveness of products like water filters. Committed to sustainability, Verdex utilizes biodegradable and bioresorbable polymers in its processes, ensuring that its production methods are environmentally friendly. Founded in 2011, the company aims to unlock the potential of nanofibers and improve quality of life through its advanced materials.

TippingPoint Biosciences is focused on developing therapeutics that address diseases linked to defects in DNA packaging, including various cancers and neurodegenerative disorders. Utilizing a drug discovery platform, the company aims to identify innovative treatments that specifically target unique genome packaging states associated with these diseases. This approach not only facilitates the treatment of cancers but also supports the development of stem cell therapies by addressing the underlying issues of dysfunctional genome packaging. Through its efforts, TippingPoint Biosciences seeks to advance medical care and improve patient outcomes in complex genetic conditions.

VIAN Therapeutics is an early-stage biotechnology company dedicated to innovating treatments for retinal diseases. The company is developing a first-in-class, non-invasive eyedrop intended to replace traditional injections for conditions such as age-related macular degeneration and diabetic macular edema. With robust preclinical data and ongoing clinical trials, VIAN aims to meet significant unmet medical needs in the retinal disease market, which is valued at $15 billion. Additionally, the company is engaged in the creation of peptide drugs that enhance efficacy and safety for treating both ophthalmic and oncology-related conditions by targeting angiogenesis, thereby offering patients improved health outcomes.

Samphire Neuroscience is a neurotechnology company based in London, England, founded in 2021. The company focuses on women's health and lifestyle enhancement through innovative solutions. Its primary product is a headband device that employs non-invasive electrical neuromodulation to stimulate specific areas of the brain. This technology aims to alleviate symptoms commonly associated with menstrual cycles, including pain, fatigue, and mood disturbances, thereby improving the overall well-being of women.

Pannex Therapeutics is a New York-based biopharmaceutical startup focused on developing innovative cancer therapies through the use of Pannexin 1 channel (Panx1) blockers. This new class of drugs aims to inhibit multiple pathways essential for the growth, spread, and survival of cancer cells. The company's research emphasizes high specificity for cancer cells, aiming to enhance treatment effectiveness while ensuring safety. By targeting these pathways, Pannex Therapeutics seeks to transform cancer therapy and provide options that minimize side effects and reduce the risk of addiction, particularly in the context of chronic pain management.

Optimize Health is a digital healthcare provider specializing in remote patient monitoring (RPM) solutions. The company offers a user-friendly platform that incorporates both equipment and software designed to streamline the implementation of RPM programs. Its software aids healthcare providers in complying with Medicare billing requirements for RPM services while ensuring a positive experience for both patients and providers. The platform automatically tracks medication doses and sends reminders to users, leveraging Bluetooth technology to sync with smartphones and tablets. This approach empowers patients to manage their health effectively and enables physicians to achieve profitability from RPM services starting in the first month.

Leadoptik is a deep-tech company focused on developing advanced miniature imaging technology designed for minimally invasive medical procedures. Its platform enhances surgical capabilities by providing high-resolution imaging and 3D navigation in real time, allowing surgeons to visualize small anatomical structures with greater clarity than existing imaging systems. This innovative approach facilitates the early detection of cancer and improves the overall effectiveness of surgical interventions, ultimately contributing to better patient outcomes.

Pear Bio is a biotechnology company based in Boston and London that focuses on developing precision medicine therapeutics for challenging cancer cases. By analyzing tumor biopsies and blood samples from patients, the company utilizes multi-omics approaches to identify new therapeutic targets. Their proprietary immune-microtumor system allows them to test the effectiveness of drug candidates directly on patient tumor samples. Pear Bio's innovative technology includes a specialized hydrogel that cultivates tumors outside the human body, effectively simulating drug resistance and streamlining the treatment selection process. This enables the identification of the most effective therapies for individual patients, thereby reducing the reliance on trial-and-error methods in cancer treatment.

AvantGuard creats innovative solutions that manage surfaces and provide long-term protection against viruses, bacteria, and fungi/mold, in a variety of applications.

Kresko RNAtech is a biotechnology company focused on the development and production of nutraceuticals. The company specializes in identifying bioactive ribonucleic acid (RNA) from natural sources, utilizing advanced techniques such as machine learning and bioinformatics. By uncovering RNAs that may offer health benefits, Kresko RNAtech aims to enhance human well-being and help individuals manage stressful and changing conditions through innovative RNA technologies.

Geltor, Inc. is a biodesign company based in San Leandro, California, that specializes in producing bioactive, animal-free collagens and proteins for various applications in beauty, nutrition, and wellness. Established in 2015, Geltor offers innovative products such as Collume, which promotes skincare cellular regeneration and dermal synthesis, and HumaColl21, which enhances skin health by boosting collagen and elastin levels. Additionally, the company provides vegan collagen peptides and other novel proteins designed for functional food and nutraceutical formulations. Geltor's products are sustainably cultivated and clinically validated, allowing businesses to create effective, plant-based solutions that contribute to a more sustainable future.

Ten63 Therapeutics is a biotechnology company focused on developing innovative therapeutics for challenging diseases, particularly those involving targets previously considered undruggable. Founded in 2017 and based in Chapel Hill, North Carolina, the company utilizes its proprietary platform, COPPER, which integrates advanced artificial intelligence and state-of-the-art physical models to explore vast chemical spaces. By employing low-residual, machine learning-based computational chemistry alongside superlinear search algorithms, Ten63 Therapeutics aims to identify and optimize drug candidates effectively. Their approach includes proprietary scaffold redesign and hopping technology, enabling the screening of trillions of molecules to predict resistance and redesign antibodies. This combination of techniques positions Ten63 Therapeutics at the forefront of developing durable treatments for some of the most lethal diseases.

Vitarka Therapeutics is a London-based company focused on developing medical technologies and solutions for various types of cancer. The company has created a targeted non-viral delivery platform aimed at intracellular targets in oncology, neuroscience, and neurodegeneration. This innovative platform works by activating the immune system and normalizing tumor vasculature, significantly improving outcomes for late-stage patients suffering from lung, colon, breast, and other cancers. By utilizing re-engineered pore-forming proteins for cell-specific targeting and facilitating the endosomal release of therapeutic cargo, Vitarka Therapeutics aims to provide cancer patients with renewed hope and the potential to lead more normal lives.

AuraSense is focused on enhancing neurological assessments through the integration of artificial intelligence and automation. The company has developed a digital touch technology that enables the detection of early signs of limb damage, facilitating remote physical examinations for various diseases. By combining elements of video game technology with practical medical procedures, AuraSense provides neurologists with a data-driven and quantifiable approach to evaluate patients' cognitive and physical health. This innovation allows for accurate performance assessments, leading to personalized treatment plans tailored to individual patient needs, ultimately aiming to improve health outcomes.

Beeflow S.A., founded in 2016 and based in Buenos Aires, Argentina, specializes in providing professional pollination services to farmers. The company leverages scientific knowledge and technology to enhance bee populations, developing organic compounds that improve the immune systems of bees and guide them to pollinate specific crops. This approach not only helps increase crop yields—reported to be between 20-90% for various fruits such as blueberries, almonds, raspberries, and kiwifruit—but also addresses the decline in bee populations. By focusing on the health and efficiency of bees, Beeflow aims to maintain the security of plant ecosystems and support sustainable agriculture practices.

Cayuga Biotech is a startup focused on developing innovative hemostatic drugs and devices aimed at reducing uncontrollable bleeding, a leading cause of death from traumatic injuries. The company utilizes a polyphosphate-based drug that enhances the body's natural clotting ability, effectively promoting clot formation at injury sites while minimizing potential side effects. Cayuga's product pipeline includes a clinic-ready drug for life-threatening bleeding and therapeutics in the discovery stage for rare inherited bleeding disorders, central nervous system bleeding, severe burns, and non-healing wounds. By harnessing the body's innate coagulation response, Cayuga Biotech aims to improve survival rates and reduce disability associated with trauma.

Particella specializes in the development of innovative lipid nanoparticle technology designed for the oral delivery of mRNA and other nucleic acids. This proprietary approach aims to transform the way biological medicines are administered by utilizing the intestinal tract to secrete proteins into the bloodstream, effectively allowing for the conversion of protein biologics into oral drugs. The company’s technology seeks to address existing limitations in the delivery of biological medicines, presenting potential advancements in preventing gastrointestinal diseases in patients.

DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing gene therapy treatments specifically for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, DNALite utilizes innovative oral lipid nanoparticle technology to deliver mRNA and pDNA directly to intestinal stem cells. This approach targets the underlying causes of diseases such as Familial Adenomatous Polyposis, a hereditary form of colorectal cancer that often necessitates invasive surgeries in adolescents. By enabling the intestinal tract to secrete therapeutic proteins into the bloodstream, DNALite aims to transform conventional protein biologics into oral medications, potentially improving patient outcomes and accessibility to treatment.

Kolibri is a biotechnology company focused on addressing the challenges of large-scale cell culture, which is crucial for the accessibility and affordability of cell and gene therapies, as well as clean meat production. The company has developed a proprietary cell-engineering platform that utilizes innovative techniques in acoustics and biology. This platform features bioreactors designed to grow cells efficiently using acoustic waves, resulting in a yield increase of up to 90 times while significantly reducing production costs by up to 50 times. By enhancing the bioproduction of biologics, Kolibri aims to facilitate patient access to gene therapies and next-generation vaccines, thereby contributing to advancements in drug development and healthcare.

Cell BioEngines, Inc. is a clinical-stage biotechnology company dedicated to the development of allogeneic "off-the-shelf" stem cell therapies for the treatment of various human diseases, with a particular focus on oncology. The company has created a blood stem cell-derived epigenetic platform designed to address challenges related to donor source availability, cellular potency, and the complexities of manufacturing clinical-grade cell products. By leveraging this innovative platform, Cell BioEngines aims to produce cell-based therapies that can provide long-lasting benefits to patients, ultimately striving to transform cancer into a curable disease.

Renegade.bio is a biotechnology startup focused on creating and implementing high throughput diagnostics for the detection of novel infectious diseases. The company specializes in developing innovative diagnostics and assays that aid in drug development, utilizing advanced techniques such as biomarker discovery, polymerase chain reaction (PCR), next-generation sequencing (NGS), and liquid chromatography-mass spectrometry (LC-MS). This expertise enables healthcare organizations to offer diagnostic testing across various settings, including individuals, workplaces, schools, communities, events, concerts, and festivals.

Mimio Health is a nutraceutical company dedicated to the research and production of mimetic supplements. Its innovative fasting mimetic formulation is based on clinical research and utilizes a carefully selected combination of bioactive human metabolites. This formulation aims to replicate the body’s natural response to fasting, offering the potential health benefits of fasting without the need to undergo the fasting process. Mimio's products focus on promoting cellular health, providing anti-inflammatory and antioxidant effects that may help combat age-related chronic inflammation and cellular damage.

FluoSphera is a company focused on the development of innovative drugs that minimize adverse side effects and reduce reliance on animal testing. By addressing the complexities of human physiological responses, FluoSphera aims to assist organizations in creating safer pharmaceuticals and protecting populations from harmful compounds. Their approach emphasizes efficiency in drug discovery, ultimately enhancing public health and safety.