Spero Ventures

Mast Reforestation specializes in restoring forests damaged by wildfires. It offers a comprehensive suite of services, including seed collection, cultivation, planting, monitoring, and financing through carbon removal credits. By removing financial barriers, Mast enables landowners to reforest their lands at no cost, contributing significantly to climate change mitigation.

Aralez Bio is a biotechnology company specializing in the sustainable production of noncanonical amino acids (ncAAs), also known as unusual or unnatural amino acids. The company has developed a novel enzymatic method that allows for the synthesis of over 100 ncAAs with perfect enantiopurity in a single step, producing water as the sole byproduct. This proprietary approach provides clients in various sectors, including pharmaceuticals, agriculture, and functional materials, with access to essential amino acids needed for innovation and development in their respective fields.

Corvus Robotics develops indoor drones specifically designed for warehouse inventory management. These drones facilitate data collection and analytics, enabling continuous cycle counting and conducting inspections within warehouse and manufacturing environments. The software integrated with the drones provides comprehensive analytics and audit capabilities, helping businesses identify and resolve discrepancies more efficiently. By streamlining inventory processes, Corvus Robotics aims to enhance operational efficiency and inform financial decision-making for its clients.

Leaf Agriculture is a technology company based in Florianopolis, Brazil, founded in 2017. It specializes in developing a unified application programming interface (API) platform that offers data services tailored for the agriculture industry. This platform facilitates seamless access to agricultural data by connecting various AgTech APIs, enabling users to validate access and retrieve information through a single API. Leaf Agriculture aims to enhance the efficiency and effectiveness of agricultural practices by leveraging digital solutions to improve data management and accessibility in the sector.

Juno is an insurance company focused on providing child insurance solutions for parents, catering to families from the stage of expecting a child through to empty nesting. The company offers products designed to cover serious diseases and disabilities affecting children, aiming to support nearly 2 million families in the United States who are impacted by rare diseases. Juno sells its insurance products through employers, delivering financial assistance and personalized guidance to parents seeking long-term protection for their children in the event of severe illness or disability.

Telo Trucks is a manufacturer of compact electric vehicle trucks designed for urban dwellers and outdoor enthusiasts. The company focuses on creating affordable, cleverly designed trucks that cater to the needs of city workers and weekend adventurers alike. By providing efficient electric vehicle options, Telo Trucks aims to enhance the urban living experience while promoting sustainable transportation solutions.

Tiny Health is a prominent microbiome health platform focused on addressing chronic health conditions and optimizing overall well-being. The company offers innovative at-home microbiome testing kits, including the Gut Health Test specifically designed for pregnant mothers and their babies, as well as tests for older children and adults and Vaginal Health Tests. By utilizing shotgun metagenomics, Tiny Health provides families with personalized insights into their gut and vaginal microbiomes, allowing them to make informed dietary and lifestyle changes. To date, approximately 30,000 families have relied on Tiny Health's expertise to correct microbiome imbalances and enhance health outcomes, with many experiencing significant symptom reduction or even reversal of chronic conditions. The team at Tiny Health comprises leading scientists and medical professionals from prestigious institutions, ensuring a strong foundation in evidence-based health solutions.

Eli is a digital platform that simplifies access to incentives, rebates, and low-interest financing for contractors, installers, and retailers involved in consumer decarbonization projects. These projects encompass a range of technologies, including heat pumps, electric vehicle chargers, heat pump water heaters, solar energy systems, and battery storage solutions. Eli’s technology is built upon extensive user testing and real-world data, aiming to assist individuals facing significant barriers to access these programs. The platform effectively screens and qualifies applicants for various incentives by navigating complex eligibility rules, verifying income, and collecting necessary documentation, all while providing personalized information about incentive eligibility. This approach ensures that users receive comprehensive support without the need to visit multiple third-party websites, enabling businesses to maximize the incentives available to them.

Founded in 2015, Base Operations provides a threat intelligence platform that aggregates, visualizes, and interprets street-level crime data. Its solutions include threat assessments, sophisticated visualizations, neighborhood threat ratings, and deployment services, helping organizations minimize risk and protect people and assets globally.

TalkshopLive operates a social streaming platform designed for interactive live shopping experiences. Its platform enables sellers to host live shows, display products, engage with buyers in real-time, and process transactions within the video player.

Confirm HR, Inc. is a data-driven hiring platform founded in November 2019 and headquartered in San Francisco, California. The company has developed an application that assists organizations in making informed hiring decisions by collecting feedback from secondary and backchannel references. This application helps identify candidate traits, verify compatibility, and reduce bias, thereby improving the chances of hiring qualified candidates. Confirm's platform utilizes quantitative methods to assess candidate quality, allowing employers to uncover the right skills and credentials for job roles. By streamlining the hiring process, Confirm aims to match job seekers with their ideal positions more efficiently, facilitating better talent decisions without the influence of subjectivity or politics.

OOVA is a fertility diagnostic company that develops a personalized fertility assessment platform based on a paper-based urine test strip that measures hormones in daily samples. The system builds a longitudinal fertility profile using biochemistry and artificial intelligence to guide cycle management, menstrual health after pregnancy, and progression toward menopause. Originating as a spin-out from Mount Sinai Hospital in New York, OOVA aims to help users understand pregnancy prospects, identify reasons for conception challenges, and detect reproductive health issues such as PCOS. Its test kit measures luteinizing hormone and progesterone over a short window, with results delivered through a mobile application to support wellness guidance for users and input for healthcare providers. Founded in 2017 and based in New York, the company focuses on consumer-accessible diagnostics designed to empower women in conceiving and monitoring reproductive health.

Hyro develops a conversational artificial intelligence platform that enhances user interactions across various digital channels. By leveraging natural language understanding, the platform allows organizations to create plug-and-play AI assistants capable of engaging customers through voice and chat. Hyro's innovative approach enables seamless ingestion of existing data to automatically build knowledge graphs, facilitating frictionless deployment and maintenance without the need for integration, playbooks, or extensive training data. The platform also features an advanced analytics dashboard, allowing organizations to customize conversations and improve customer engagement effectively.

Euclid Power specializes in the development of platforms for renewable energy project management, investment, and execution. It offers data-driven systems to guide through project lifecycle stages, including energy storage modeling, risk management, project feasibility assessment, underwriting, and asset management.

Clarity Movement transforms how governments, communities, and businesses understand and respond to air pollution with IoT-based air quality monitoring technology. Our turn-key air quality monitoring solution supplements existing regulatory monitors with networks of hundreds to thousands of continuously-calibrated air quality sensors, making air quality management more accessible, cost-effective, and actionable than ever before. Founded in 2014, we have now deployed our next-generation, highly-accurate indicative air quality monitoring networks in more than 60 countries around the world — empowering our customers to build healthier communities with better data.

Singularity Energy, Inc. is a technology company focused on developing a platform for real-time carbon tracking and energy optimization. Founded in 2018 and headquartered in Cambridge, Massachusetts, the company utilizes artificial intelligence to integrate real-time carbon dioxide signals from the energy grid into its solutions. This enables corporate clients, including climate regulators and sustainability directors, to visualize and co-optimize their energy usage and carbon emissions effectively. Singularity Energy's innovative approach combines data analytics with carbon forecasting and optimization algorithms, allowing organizations to minimize their emissions while maximizing economic benefits. The company's mission is to support entities in achieving their sustainability goals with transparency and confidence.

Empowerly, Inc. is an education technology company based in San Mateo, California, that specializes in personalized college counseling and tutoring services for students in grades 7-12, as well as transfer and graduate students. Formerly known as Synocate, the company utilizes a data-driven approach to provide tailored college application counseling, connecting students with trained counselors who cater to their individual needs. Empowerly's platform operates on a team-based human intelligence model, facilitating personalized guidance for college admissions and career planning. By leveraging expert recommendations, Empowerly aims to help students achieve their goals of acceptance into preferred universities and securing internships, ultimately empowering them to succeed in their academic and professional journeys.

Huckleberry makes behavioral expertise accessible and affordable to all families by combining AI with human experts, starting with children's sleep.

Gencove specializes in a software platform for efficient and cost-effective genome sequencing using low-pass sequencing methods. This enables high-throughput genomics research and diagnostics across various species.

BIOMILQ develops lab-grown human milk ingredients from cultured mammary cells to support infant nutrition. Founded in 2020 and based in Durham, North Carolina, the company is women-owned and science-led, building a mammary biomanufacturing platform to produce bioauthentic human milk ingredients for early-life nutrition. The platform combines human mammary cells with a scalable manufacturing process to create milk ingredients that promote gut, immune, and brain development, offering families a nutritious and sustainable option for feeding babies.

Mast Reforestation specializes in restoring forests damaged by wildfires. It offers a comprehensive suite of services, including seed collection, cultivation, planting, monitoring, and financing through carbon removal credits. By removing financial barriers, Mast enables landowners to reforest their lands at no cost, contributing significantly to climate change mitigation.

AllHere, Inc. is a Boston-based company that focuses on reducing chronic absenteeism in K-12 schools through its intervention management platform. The platform offers various tools, including referral management to analyze chronic absence data at multiple levels, intervention tracking applications for monitoring attendance interventions such as home visits and mentoring, and automated analytics reports to assess the effectiveness of intervention programs. Additionally, AllHere employs artificial intelligence and supervised machine learning to enhance its chatbot software, facilitating real-time, one-on-one communication between schools and families. This approach aims to create engaging experiences that support student recruitment, retention, and success by providing timely assistance and information to families.

Nana is a vertically integrated trade skills school that specializes in training individuals in appliance repair. The organization aims to address the impending job displacement caused by technological automation, specifically targeting the 35 million people projected to lose their jobs by 2030. Nana provides comprehensive training in trade skills, enhances participants' experience through a mentorship program, and facilitates job placements in collaboration with leading brands such as Samsung and GE. By refining this educational and employment pipeline, Nana not only equips a new generation of tradespeople with essential skills but also plays a critical role in revitalizing America's workforce and generating economic opportunities.

Hyro develops a conversational artificial intelligence platform that enhances user interactions across various digital channels. By leveraging natural language understanding, the platform allows organizations to create plug-and-play AI assistants capable of engaging customers through voice and chat. Hyro's innovative approach enables seamless ingestion of existing data to automatically build knowledge graphs, facilitating frictionless deployment and maintenance without the need for integration, playbooks, or extensive training data. The platform also features an advanced analytics dashboard, allowing organizations to customize conversations and improve customer engagement effectively.

Tortuga AgTech specializes in agricultural automation, using robotics and AI to perform labor-intensive tasks such as harvesting. Their mission is to enhance farming methods for a healthier society and ecosystem by enabling growers to produce better, more sustainable crops.

TalkshopLive operates a social streaming platform designed for interactive live shopping experiences. Its platform enables sellers to host live shows, display products, engage with buyers in real-time, and process transactions within the video player.

BrainsGate is a medical device company that develops therapies for central nervous system diseases, focusing on acute ischemic stroke. Its platform uses electrical stimulation of the spheno‑palatine ganglion (SPG) via a miniature electrode implanted in the roof of the mouth. The procedure is minimally invasive, performed at bedside under local anesthesia, and is designed to increase cerebral blood flow. The company has completed several clinical studies, including the ImPACT‑1 pilot, a 300‑patient randomized controlled trial, and is currently conducting the ImpACT‑24b pivotal study. Founded in 2000, BrainsGate is headquartered in Caesarea, Israel.

MetaMap is a customer identity platform that provides comprehensive, accurate data in emerging markets to help merchants understand their users and broaden opportunities. Its identity verification tools draw on regional data sources and are consolidated globally, spanning local government checks to global watchlists, enabling businesses to deliver trust-based services to more people. By serving developers and enterprises, MetaMap supports scalable, differentiated digital identity solutions that transform uncertain online interactions into trustworthy engagements.

Nana is a vertically integrated trade skills school that specializes in training individuals in appliance repair. The organization aims to address the impending job displacement caused by technological automation, specifically targeting the 35 million people projected to lose their jobs by 2030. Nana provides comprehensive training in trade skills, enhances participants' experience through a mentorship program, and facilitates job placements in collaboration with leading brands such as Samsung and GE. By refining this educational and employment pipeline, Nana not only equips a new generation of tradespeople with essential skills but also plays a critical role in revitalizing America's workforce and generating economic opportunities.

Fluent Forever Inc. is a language learning application company founded in 2013 and based in Chicago, Illinois. The company's app is designed to help users learn and retain foreign languages effectively, offering courses in languages such as Spanish, French, Italian, Russian, German, Portuguese, Korean, and Japanese. Fluent Forever provides a range of resources, including learning guides, pictures, animated templates, grammar books, and voice training tips, allowing users to customize their learning experience. The platform emphasizes improving pronunciation and fluency, making it a comprehensive tool for language acquisition.

Fiveable, Inc. is an educational technology company based in Milwaukee, Wisconsin, founded in 2018. It operates an interactive social learning platform designed for Advanced Placement (AP) students and teachers, aiming to foster educational equity. The platform combines content, community, and courses to enhance the learning experience. It features a comprehensive content library and interactive community spaces, allowing students to engage with peers studying similar subjects. Fiveable offers online instruction led by accredited teachers across various disciplines, including history, social sciences, STEM, and languages. The company's mission is to empower students by building their skills and confidence, enabling them to earn college credit through placement exams and succeed in their educational endeavors.

Empowerly, Inc. is an education technology company based in San Mateo, California, that specializes in personalized college counseling and tutoring services for students in grades 7-12, as well as transfer and graduate students. Formerly known as Synocate, the company utilizes a data-driven approach to provide tailored college application counseling, connecting students with trained counselors who cater to their individual needs. Empowerly's platform operates on a team-based human intelligence model, facilitating personalized guidance for college admissions and career planning. By leveraging expert recommendations, Empowerly aims to help students achieve their goals of acceptance into preferred universities and securing internships, ultimately empowering them to succeed in their academic and professional journeys.

Skillshare, Inc. is an online learning community that was founded in 2010 and is headquartered in New York, New York. The platform offers a diverse array of classes in various fields such as illustration, design, photography, video, and business. It provides practitioners the opportunity to take online courses, watch instructional videos, engage in projects and workshops, and even teach their own classes. By facilitating a creative space for individuals to learn and improve their skills, Skillshare enables members to explore new interests and enhance their expertise in multiple domains, from culinary arts to technology and entrepreneurship.

Huckleberry makes behavioral expertise accessible and affordable to all families by combining AI with human experts, starting with children's sleep.

MetaMap is a customer identity platform that provides comprehensive, accurate data in emerging markets to help merchants understand their users and broaden opportunities. Its identity verification tools draw on regional data sources and are consolidated globally, spanning local government checks to global watchlists, enabling businesses to deliver trust-based services to more people. By serving developers and enterprises, MetaMap supports scalable, differentiated digital identity solutions that transform uncertain online interactions into trustworthy engagements.

Clarity Movement transforms how governments, communities, and businesses understand and respond to air pollution with IoT-based air quality monitoring technology. Our turn-key air quality monitoring solution supplements existing regulatory monitors with networks of hundreds to thousands of continuously-calibrated air quality sensors, making air quality management more accessible, cost-effective, and actionable than ever before. Founded in 2014, we have now deployed our next-generation, highly-accurate indicative air quality monitoring networks in more than 60 countries around the world — empowering our customers to build healthier communities with better data.

RushTix, Inc. is a subscription-based live entertainment platform founded in 2014 and headquartered in San Francisco, California. The company specializes in offering a diverse range of live events, including music, health, and comedy shows. Additionally, RushTix has developed an AI-driven platform that enhances interactive entertainment, allowing users to engage in immersive 3D story worlds and real-time gaming experiences. Through its product, ReelMagic, users can influence narratives and interact with virtual characters while creators have the opportunity to monetize their experiences within a dedicated marketplace. RushTix aims to foster connections among individuals through innovative online experiences.

Founded in 2015, Base Operations provides a threat intelligence platform that aggregates, visualizes, and interprets street-level crime data. Its solutions include threat assessments, sophisticated visualizations, neighborhood threat ratings, and deployment services, helping organizations minimize risk and protect people and assets globally.

INDUS.AI is a construction intelligence platform that provides real-time visibility into construction sites for real estate investors, owners, developers, and general contractors. The platform uses live video from secure cameras to identify inefficiencies, monitor productivity, and surface risks, enabling project teams to optimize labor, equipment, and materials, reconcile over-billed charges, and adjust schedules. It aims to improve safety, efficiency, and transparency on projects. Founded in 2017, INDUS.AI has offices in San Francisco and Toronto and serves clients in the United States, Canada, Hong Kong, and Brazil.

Core is a health, wellness, and fitness company based in San Francisco, California. It specializes in developing innovative meditation device technology that utilizes haptics and biofeedback to enhance the meditation experience. By guiding users through their meditation journey and personalizing techniques, Core aims to help individuals improve their ability to meditate, relax, and achieve better sleep.

Tortuga AgTech specializes in agricultural automation, using robotics and AI to perform labor-intensive tasks such as harvesting. Their mission is to enhance farming methods for a healthier society and ecosystem by enabling growers to produce better, more sustainable crops.

Gencove specializes in a software platform for efficient and cost-effective genome sequencing using low-pass sequencing methods. This enables high-throughput genomics research and diagnostics across various species.

Huckleberry makes behavioral expertise accessible and affordable to all families by combining AI with human experts, starting with children's sleep.

ROAM is a San Francisco-based robotics company. Their goal is to reinvent the way they make powered orthotics - otherwise known as exoskeletons - making them inexpensive, comfortable, and safe for home use. They are also developing a new class of exoskeleton that uses high strength fabrics and a pneumatic powertrain, resulting in power to weight ratios that are unmatched by existing exoskeleton systems at a significantly lower cost.

SafeTraces specializes in sustainable indoor air quality management. It offers a unique IAQ verification system that actively assesses pathogen risk, ensuring safer indoor environments with proven safety measures, backed by the first UL mark for verified ventilation and filtration.

RevUp Software is bringing leading-edge, easy to use analytics to Non-Profits, Academic Institutions and Political Organizations. We help fundraisers, while working with existing software, create new ways to identify, target, and engage their networks.

INDUS.AI is a construction intelligence platform that provides real-time visibility into construction sites for real estate investors, owners, developers, and general contractors. The platform uses live video from secure cameras to identify inefficiencies, monitor productivity, and surface risks, enabling project teams to optimize labor, equipment, and materials, reconcile over-billed charges, and adjust schedules. It aims to improve safety, efficiency, and transparency on projects. Founded in 2017, INDUS.AI has offices in San Francisco and Toronto and serves clients in the United States, Canada, Hong Kong, and Brazil.

Skillshare, Inc. is an online learning community that was founded in 2010 and is headquartered in New York, New York. The platform offers a diverse array of classes in various fields such as illustration, design, photography, video, and business. It provides practitioners the opportunity to take online courses, watch instructional videos, engage in projects and workshops, and even teach their own classes. By facilitating a creative space for individuals to learn and improve their skills, Skillshare enables members to explore new interests and enhance their expertise in multiple domains, from culinary arts to technology and entrepreneurship.

Mast Reforestation specializes in restoring forests damaged by wildfires. It offers a comprehensive suite of services, including seed collection, cultivation, planting, monitoring, and financing through carbon removal credits. By removing financial barriers, Mast enables landowners to reforest their lands at no cost, contributing significantly to climate change mitigation.

Persist AI is a company that aids pharmaceutical firms in the development of long-acting drug formulations by leveraging artificial intelligence and automation. Traditional formulation development is a lengthy process, typically spanning 5 to 10 years, which includes extensive pre-clinical and clinical testing phases. Persist AI aims to significantly reduce this timeline by streamlining pre-clinical formulation development to just three months, enhancing the efficiency of the drug development process by 50%. The company employs AI-driven automation technologies, such as automated drug release testing and high-throughput formulation screening, to facilitate quicker and more reliable drug formulation. By doing so, Persist AI not only accelerates drug development but also contributes to improving patient outcomes.