MiroBio's platform is based on ground-breaking research by their scientific founders at the University of Oxford delineating how immune cells communicate and how they are activated. These insights have enabled MiroBio to create antibodies that can leverage natural signalling mechanisms to restore immune system balance and control.
Dren Bio is a biotechnology company with a portfolio of attractive projects focused on powerful protein engineering technologies for the depletion of cells, protein aggregates, and other disease-causing agents. It is a holding company business model aimed at creating value with multiple projects as stand-alone assets.
Nomic is a bioengineering company working to make the human proteome as broadly and easily accessible as the human genome. They are building the nELISA, a next-generation ELISA platform for measuring proteins at scale and at high throughput. They offer scientists protein profiling solutions to empower them to decide the scope and scale of their experiments.
Odyssey Therapeutics is a biotechnology company pioneering the efficient development of next-generation immunomodulators and oncology medicines. Odyssey is making a transformational impact on the field of drug discovery and is accelerating the path to clinical development to drive the creation of more effective precision medicines. The company's integrated drug-hunting engine is designed to accelerate drug discovery by unlocking targets with great potential and minimizing attrition.
Pulmocide Ltd, a company focused on the discovery and development of a new generation of inhaled medicines for the treatment of serious viral and fungal infections of the respiratory tract.
Dren Bio is a biotechnology company with a portfolio of attractive projects focused on powerful protein engineering technologies for the depletion of cells, protein aggregates, and other disease-causing agents. It is a holding company business model aimed at creating value with multiple projects as stand-alone assets.
MiroBio's platform is based on ground-breaking research by their scientific founders at the University of Oxford delineating how immune cells communicate and how they are activated. These insights have enabled MiroBio to create antibodies that can leverage natural signalling mechanisms to restore immune system balance and control.
Atox Bio is a biotechnology company that specializes in infectious diseases, immunomodulators, and critical care.It focuses on novel modulators of the immune response that target key multiple and interrelated pathways of both the adaptive and innate immune response that play critical roles in infectious and inflammatory diseases as well as ischemia/reperfusion injuries. The company was founded in 2003 and headquartered in HaMerkaz, Israel.
Pulmocide Ltd, a company focused on the discovery and development of a new generation of inhaled medicines for the treatment of serious viral and fungal infections of the respiratory tract.
Spero Therapeutics is developing first in class therapeutics for treatment of gram-negative infections. The company leverages a top-tier chemistry and microbiology team, an efficient virtual approach to drug development, and a focus on high potential, novel mechanisms to fill the unmet need for early stage therapeutics targeting serious bacterial infections. Its lead program addresses a novel target driving virulence and persistence of pseudomonas aeruginosa infections and other gram-negative pathogens.
Translate Bio is a biotechnology company that in biotechnology, RNA therapeutics, and rare diseases. Translate Bio is a therapeutics company developing a new class of potentially transformative medicines to treat diseases caused by protein or gene dysfunction.
Spero Therapeutics is developing first in class therapeutics for treatment of gram-negative infections. The company leverages a top-tier chemistry and microbiology team, an efficient virtual approach to drug development, and a focus on high potential, novel mechanisms to fill the unmet need for early stage therapeutics targeting serious bacterial infections. Its lead program addresses a novel target driving virulence and persistence of pseudomonas aeruginosa infections and other gram-negative pathogens.
Asceneuron develops effective therapeutics for orphan tauopathies and Alzheimer’s disease. By focusing on areas of high unmet medical need, Asceneuron aspires to become a leading biotech company specialized in small molecule drug discovery for neurodegenerative diseases. Tauopathies are currently untreatable neurodegenerative diseases that rapidly progress towards debilitating conditions. The appearance of deposits of the microtubule-associated tau protein as e.g. neurofibrillary tangles in neurons of the brain is a common feature of tauopathies that is shared with Alzheimer’s disease. Neuronal tau deposits are known to be a major contributor to neurodegeneration and mutations in the tau gene are causative of the tauopathy fronto-temporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Due to increasing life expectancy, Alzheimer’s disease is viewed as one of the largest healthcare problems of this century, imposing a major economic burden on societies in the Western and developing world. Current treatment options provide limited benefits supporting the urgent need for more efficacious and better tolerated medicines that address symptomatic relief as well as disease progression.
Principia Biopharma is a private, pre-clinical stage company initially focused on the discovery and development of differentiated small molecule drugs targeting inflammatory/autoimmune diseases as well as cancer. The company expects to submit an IND for its lead program in 2013 and continues to invest in additional programs and its reversible covalent platform.
Translate Bio is a biotechnology company that in biotechnology, RNA therapeutics, and rare diseases. Translate Bio is a therapeutics company developing a new class of potentially transformative medicines to treat diseases caused by protein or gene dysfunction.
Spero Therapeutics is developing first in class therapeutics for treatment of gram-negative infections. The company leverages a top-tier chemistry and microbiology team, an efficient virtual approach to drug development, and a focus on high potential, novel mechanisms to fill the unmet need for early stage therapeutics targeting serious bacterial infections. Its lead program addresses a novel target driving virulence and persistence of pseudomonas aeruginosa infections and other gram-negative pathogens.
Atox Bio is a biotechnology company that specializes in infectious diseases, immunomodulators, and critical care.It focuses on novel modulators of the immune response that target key multiple and interrelated pathways of both the adaptive and innate immune response that play critical roles in infectious and inflammatory diseases as well as ischemia/reperfusion injuries. The company was founded in 2003 and headquartered in HaMerkaz, Israel.
Principia Biopharma is a private, pre-clinical stage company initially focused on the discovery and development of differentiated small molecule drugs targeting inflammatory/autoimmune diseases as well as cancer. The company expects to submit an IND for its lead program in 2013 and continues to invest in additional programs and its reversible covalent platform.
Spero Therapeutics is developing first in class therapeutics for treatment of gram-negative infections. The company leverages a top-tier chemistry and microbiology team, an efficient virtual approach to drug development, and a focus on high potential, novel mechanisms to fill the unmet need for early stage therapeutics targeting serious bacterial infections. Its lead program addresses a novel target driving virulence and persistence of pseudomonas aeruginosa infections and other gram-negative pathogens.
Alios is discovering and developing novel therapeutic agents based on three platform technologies including: small molecule activators of innate immunity antiviral pathways (RNase L activation), phosphate protected nucleotide prodrug chemistry, and glycoprotein-engineering of interferons (Glycoferonâ). This complementary group of platform technologies has the potential to generate a number of distinct therapeutic products to treat a variety of serious viral infections such as chronic hepatitis B and C, HIV infection, and respiratory viruses (e.g. pandemic influenza) and emerging viral diseases (e.g. SARS).
Bird Rock Bio is focused on the discovery and development of novel biologic therapeutics that meet the medical and commercial needs for China’s patients and healthcare system and that have the potential to be disruptive globally. RYI-008 is a novel, extremely potent monoclonal antibody that is highly selective to IL-6, a cytokine widely implicated in inflammation and cancer. In addition to RYI-008, RuiYi has a growing pipeline of monoclonal antibodies from its internal discovery efforts utilizing a series of the Company’s technologies, including the iCAP (intramembranous Conformation Antigen Presenting) system. Targets include a select subset of G protein coupled receptors (GPCR), where specificity in binding is critical but has proven difficult to achieve with small molecule modulators.
We are using induced pluripotent stem cells for drug discovery and development. Focused on neurodegenerative diseases such as SMA, ALS and Parkinson's, and other major unmet medical needs.
Principia Biopharma is a private, pre-clinical stage company initially focused on the discovery and development of differentiated small molecule drugs targeting inflammatory/autoimmune diseases as well as cancer. The company expects to submit an IND for its lead program in 2013 and continues to invest in additional programs and its reversible covalent platform.
Translate Bio is a biotechnology company that in biotechnology, RNA therapeutics, and rare diseases. Translate Bio is a therapeutics company developing a new class of potentially transformative medicines to treat diseases caused by protein or gene dysfunction.
We are using induced pluripotent stem cells for drug discovery and development. Focused on neurodegenerative diseases such as SMA, ALS and Parkinson's, and other major unmet medical needs.
Trinity Biosystems, Inc. engages in the development and formulation of oral therapeutic proteins. It involves in developing vaccines in the areas of respiratory, digestive, and sexually transmitted diseases, as well as transporting proteins, peptides, and other macromolecules. The company was founded in 2002 and is based in Menlo Park, California.
Bird Rock Bio is focused on the discovery and development of novel biologic therapeutics that meet the medical and commercial needs for China’s patients and healthcare system and that have the potential to be disruptive globally. RYI-008 is a novel, extremely potent monoclonal antibody that is highly selective to IL-6, a cytokine widely implicated in inflammation and cancer. In addition to RYI-008, RuiYi has a growing pipeline of monoclonal antibodies from its internal discovery efforts utilizing a series of the Company’s technologies, including the iCAP (intramembranous Conformation Antigen Presenting) system. Targets include a select subset of G protein coupled receptors (GPCR), where specificity in binding is critical but has proven difficult to achieve with small molecule modulators.
Locus Pharmaceuticals, Inc. develops a drug design and development platform for oral drug therapies in the areas of unmet medical needs. Its fragment-based computational drug design technology is used for the discovery and development of compounds for the treatment of unmet medical needs. The company has a computational drug design technology, which is used to develop a pipeline of drug development candidates, including direct and allosteric kinase inhibitors for cancer and inflammation diseases. Locus Pharmaceuticals, Inc. was formerly known as Locus Discovery, Inc. The company was incorporated in 1998 and is based in Blue Bell, Pennsylvania. Locus Pharmaceuticals, Inc. is a former subsidiary of Sarnoff Corporation.
Morphotek is one of the leading companies in the life science industry that develops novel classes of biological-based products to treat cancer, inflammation and infectious diseases. Since its founding in 2000, Morphotek has made extraordinary progress in discovering and developing monoclonal antibodies (mABs) to treat these diseases and continues to develop additional antibody products using its proprietary technologies. Post-graduate research executed by Morphotek’s President and CEO, Dr. Nicholas Nicolaides, during his studies at Johns Hopkins Medical School was the basis for the company’s inception. It was there that Dr. Nicolaides co-invented the company's legacy technology called morphogenics. Along with the honed applications for applying morphogenics for product development refined by the company’s other co-founders, Dr. Philip Sass and Dr. Luigi Grasso, morphogenics has taken Morphotek an incredible distance in the advancement of novel pharmaceutical products and targets.
Ablynx is a biopharmaceutical company engaged in the discovery and development of Nanobodies®, a novel class of therapeutic proteins based on single-domain antibody fragments, for a range of serious human diseases, including inflammation, haematology, oncology and pulmonary disease. Today, the Company has approximately 25 projects in the pipeline and five Nanobodies in clinical development.
Onyvax is developing new cancer therapies that harness the selective power of the immune system to seek out and destroy tumor cells. Onyvax's products specifically target cancer cells, increasing the likelihood that they will be effective while minimising side effects associated with many conventional treatments. These therapies can broadly be classed as therapeutic cancer vaccines.
Therion Biologics
Venture Round in 2003
Therion Biologics Corporation is focusing on the development and commercialization of innovative vaccines for the treatment of major cancers. Currently, Therion has two lead products moving into pivotal clinical trials in the next two years: PROSTVAC-VF for prostate cancer, developed by Therion, and ALVAC-CEA/B7.1, developed in collaboration with Aventis Pasteur Ltd., for colorectal cancer. The company also has a broad pipeline of vaccines in early clinical development for treatment of other major cancers, including breast cancer, lung cancer, melanoma and other solid tumors. Therion's partners include Aventis Pasteur, the National Cancer Institute and a network of leading clinical institutions around the world. Therion is a privately-held biotechnology company headquartered in Cambridge, Massachusetts. Therion's goal is to generate safe and effective therapeutic cancer vaccines that stimulate the immune system to specifically attack cancer cells, and thereby stabilize disease or induce tumor regression, improve patients' quality of life, and increase patient survival. While there has been significant progress in the treatment of some cancers, the prognosis for many cancer patients remains poor. For example, colorectal cancer affects an estimated 130,000 new patients and accounts for 56,300 deaths each year in the United States. Prostate cancer is the second leading cause of cancer death in men, with an estimated 180,400 new cases and 31,900 deaths in the U.S. annually. Recent advances in immunology and tumor biology have opened the door for the development of new generation therapeutic cancer vaccines. In particular, scientists now have a better understanding of the key molecular signals involved in eliciting potent and specific immune responses. This allows researchers to engineer vaccines that induce elements of the immune system required to eliminate cancer cells. Therion is at the forefront, quickly moving leading research into clinical development. Capitalizing on these recent scientific advances, Therion is targeting many of the major cancers currently lacking adequate treatment. Therion's therapeutic cancer vaccines for breast, lung, colorectal and prostate cancers, and melanoma address a majority of the large and rapidly growing market for cancer treatments.
Therion Biologics
Venture Round in 2001
Therion Biologics Corporation is focusing on the development and commercialization of innovative vaccines for the treatment of major cancers. Currently, Therion has two lead products moving into pivotal clinical trials in the next two years: PROSTVAC-VF for prostate cancer, developed by Therion, and ALVAC-CEA/B7.1, developed in collaboration with Aventis Pasteur Ltd., for colorectal cancer. The company also has a broad pipeline of vaccines in early clinical development for treatment of other major cancers, including breast cancer, lung cancer, melanoma and other solid tumors. Therion's partners include Aventis Pasteur, the National Cancer Institute and a network of leading clinical institutions around the world. Therion is a privately-held biotechnology company headquartered in Cambridge, Massachusetts. Therion's goal is to generate safe and effective therapeutic cancer vaccines that stimulate the immune system to specifically attack cancer cells, and thereby stabilize disease or induce tumor regression, improve patients' quality of life, and increase patient survival. While there has been significant progress in the treatment of some cancers, the prognosis for many cancer patients remains poor. For example, colorectal cancer affects an estimated 130,000 new patients and accounts for 56,300 deaths each year in the United States. Prostate cancer is the second leading cause of cancer death in men, with an estimated 180,400 new cases and 31,900 deaths in the U.S. annually. Recent advances in immunology and tumor biology have opened the door for the development of new generation therapeutic cancer vaccines. In particular, scientists now have a better understanding of the key molecular signals involved in eliciting potent and specific immune responses. This allows researchers to engineer vaccines that induce elements of the immune system required to eliminate cancer cells. Therion is at the forefront, quickly moving leading research into clinical development. Capitalizing on these recent scientific advances, Therion is targeting many of the major cancers currently lacking adequate treatment. Therion's therapeutic cancer vaccines for breast, lung, colorectal and prostate cancers, and melanoma address a majority of the large and rapidly growing market for cancer treatments.
Onyvax is developing new cancer therapies that harness the selective power of the immune system to seek out and destroy tumor cells. Onyvax's products specifically target cancer cells, increasing the likelihood that they will be effective while minimising side effects associated with many conventional treatments. These therapies can broadly be classed as therapeutic cancer vaccines.
Xenogen Biosciences Corporation specializes in providing animal production and phenotyping services tailored for biopharmaceutical companies and biomedical researchers. Based in Cranbury, New Jersey, the company focuses on creating bioluminescent animal models that facilitate the testing of drug effects on genes and proteins within biological systems. Its offerings include DNA microinjection, transgene integration analysis, and custom gene targeting programs, along with a variety of specialized mouse strains. The integration of biophotonic technologies allows for real-time, non-invasive monitoring of biological processes in living organisms, thereby enhancing the drug discovery and development process. Xenogen Biosciences, formerly known as Chrysalis DNX Transgenic Sciences, operates as a subsidiary of Taconic Farms, Inc.
Xenogen Biosciences Corporation specializes in providing animal production and phenotyping services tailored for biopharmaceutical companies and biomedical researchers. Based in Cranbury, New Jersey, the company focuses on creating bioluminescent animal models that facilitate the testing of drug effects on genes and proteins within biological systems. Its offerings include DNA microinjection, transgene integration analysis, and custom gene targeting programs, along with a variety of specialized mouse strains. The integration of biophotonic technologies allows for real-time, non-invasive monitoring of biological processes in living organisms, thereby enhancing the drug discovery and development process. Xenogen Biosciences, formerly known as Chrysalis DNX Transgenic Sciences, operates as a subsidiary of Taconic Farms, Inc.
Lexicon Pharmaceuticals is a biopharmaceutical company engaged in the discovery and development of pharmaceutical products for the treatment of human diseases, including those in the fields of immunology, metabolism, cardiology, and ophthalmology. The company's drug candidates include LX1031, which has completed Phase II clinical trials for the treatment of irritable bowel syndrome and other gastrointestinal disorders; LX4211, which has completed Phase II clinical trials for the treatment of type 2 diabetes; LX2931, which is in Phase II clinical trials for the treatment of rheumatoid arthritis and other autoimmune diseases; and LX1032, which has completed Phase II clinical trials for the treatment of symptoms associated with carcinoid syndrome. Additionally, the company is developing a preclinical drug candidate, LX7101, for the treatment of glaucoma. Lexicon Pharmaceuticals has established drug discovery alliances with Bristol-Myers Squibb Company, Genentech, Inc., N.V. Organon, and Takeda Pharmaceutical Company Limited. It also has a drug development financing collaboration with Symphony Icon, a collaboration agreement with Taconic Farms, Inc., and an alliance with Nuevolution A/S for access to Nuevolution's Chemetics platform chemistry technology.
Onyvax is developing new cancer therapies that harness the selective power of the immune system to seek out and destroy tumor cells. Onyvax's products specifically target cancer cells, increasing the likelihood that they will be effective while minimising side effects associated with many conventional treatments. These therapies can broadly be classed as therapeutic cancer vaccines.