Two Bear Capital, established in 2019, is a venture capital firm headquartered in Whitefish, Montana, with additional offices in San Francisco and San Diego. The firm specializes in early-stage investments, focusing on technologies that address critical issues in human health, security, and wellness. Its investment areas include biotech, bioinformatics, machine learning, artificial intelligence, and cybersecurity. Two Bear Capital is a Registered Investment Adviser and seeks opportunities in Montana, the Pacific Northwest, and across the United States.
Montara Therapeutics is a biotechnology company focused on developing innovative therapies for central nervous system diseases. It utilizes a precision pharmacology platform that combines human genetics and machine learning to identify and validate drug targets. This approach aims to enhance the safety and effectiveness of treatments for patients suffering from neurological disorders, ultimately improving therapeutic outcomes in this challenging area of healthcare.
QuSecure
Series A in 2025
QuSecure, Inc. is a cybersecurity company based in Menlo Park, California, founded in 2019. It specializes in post-quantum security solutions to address both current and emerging cyber threats. The company offers the QuProtect software platform, which functions as a quantum-security-as-a-service framework, providing comprehensive protection for networks, cloud systems, edge devices, and satellite communications. This platform ensures a zero-trust environment and incorporates crypto agility, allowing organizations to enhance their data security infrastructure without requiring significant changes to existing systems. In addition to its software solutions, QuSecure also delivers consulting services focused on governance, compliance, security strategy, and computing education, enabling enterprises to safeguard their operations against both quantum and classical cyber threats.
Selector
Series B in 2024
Selector AI is a developer of an operational intelligence platform that focuses on managing multi-cloud infrastructures and performance-sensitive managed services. The platform utilizes AI and machine learning to analyze data from diverse sources, providing actionable insights that help network, cloud, and application operators meet their service KPIs. By enabling seamless collaboration through messaging platforms and offering search-driven querying, Selector AI enhances the user experience while automating data engineering processes. The platform also features automated anomaly detection and comparative analysis of metrics and events, empowering clients to leverage data science effectively to improve their infrastructure operations.
Talus Bio
Seed Round in 2024
Talus Bio is a biotech startup focused on drug discovery, particularly in the development of therapies targeting gene regulators for cancer treatment. The company utilizes a data-enabled platform that combines functional proteomics, automated biology, and machine learning to address the challenges associated with cancer transcription factors. Its proprietary MARMOT platform employs advanced techniques such as AI, quantitative proteomics, synthetic chemistry, and computational biology to design and analyze small-molecule drugs and proteins. This innovative approach aims to enhance drug development processes in the oncology sector, facilitating advancements in gene regulation and contributing to more effective cancer therapies.
Montara Therapeutics
Seed Round in 2024
Montara Therapeutics is a biotechnology company focused on developing innovative therapies for central nervous system diseases. It utilizes a precision pharmacology platform that combines human genetics and machine learning to identify and validate drug targets. This approach aims to enhance the safety and effectiveness of treatments for patients suffering from neurological disorders, ultimately improving therapeutic outcomes in this challenging area of healthcare.
Elisity
Series B in 2024
Elisity is a company focused on enhancing security for enterprise assets and data, addressing challenges arising from the complexities of modern work environments and mobile workforces. It has developed a cloud-based platform that utilizes least privilege access and identity-based micro-segmentation to secure network access. This platform continuously verifies user identity, location, permissions, and device behavior to provide granular access control, thereby enabling organizations to implement zero-trust security measures effectively. The team behind Elisity comprises experienced entrepreneurs with strong technical expertise in enterprise networking and security, leveraging their knowledge to cater to the needs of highly security-conscious organizations.
Binarly
Seed Round in 2024
Binarly is a firmware and software supply chain security company established in 2021, headquartered in Los Angeles, California. The company's primary offering, the Binarly Transparency Platform, is an AI-powered solution designed for device manufacturers, OEMs, and product security teams. This platform identifies known and unknown vulnerabilities, misconfigurations, and potential malicious code within firmware, employing advanced machine learning and code analysis techniques. By providing validated remediation playbooks, Binarly helps organizations significantly reduce the time and cost associated with addressing security exposures. The company leverages decades of research and expertise in program analysis to develop solutions that safeguard businesses, critical infrastructure, and consumers from emerging firmware and hardware threats.
Dymium
Seed Round in 2024
Dymium is addressing one of the most pressing issues organizations are faced with today: how to securely and cost-effectively manage the data access requirements across a proliferation of data in the midst of an advancing world of cloud technology, data analytics, distributed development environments and AI-projects. Dymium takes data protection to where your data lives rather than you having to move it, make copies of it or build yet another data lake or warehouse. The Dymium Platform uniquely combines a zero-trust architecture, real-time data transformation services and universal access policies across your existing data infrastructure wherever that data may live so that it is more secure, efficient and cost-effective to innovate. We believe that you don’t need to move your data or make more copies of your data in order for you to use it for innovation. This only opens up your organization to greater risk and unnecessary cost.
TileDB
Series B in 2023
TileDB, Inc. develops and maintains a system for managing multi-dimensional array data, particularly suited for scientific applications. The company's offerings include TileDB Embedded, a storage engine, and TileDB Cloud, which facilitates the management of array data in the cloud. Designed to handle a variety of data types, including unstructured multimodal data, TileDB addresses the complexities encountered in fields such as genomics, biomedical imaging, and multiomic data analysis. This foundational software is utilized by research teams in pharmaceuticals and biotechnology to enhance their data platforms and drive scientific discovery. Founded in 2017 and headquartered in Cambridge, Massachusetts, TileDB also has a location in Athens, Greece.
Graphiant
Series B in 2023
Graphiant Inc. is a technology company based in Silicon Valley, founded in 2020 and headquartered in Fremont, California. It specializes in developing software-defined wide area network (SD-WAN) solutions aimed at transforming enterprise networking. The company offers the Graphiant Network Edge, a software-as-a-service platform that facilitates seamless connectivity across enterprise WANs, hybrid clouds, network edges, and various clients and partners. Graphiant's technology combines the performance of traditional multiprotocol label switching with the agility of modern internet solutions, enabling network architects to design and implement enterprise-grade networks that keep pace with business demands.
Abilita Bio
Venture Round in 2023
Abilita Bio is a biotechnology company that focuses on enabling the discovery and development of drugs targeting membrane proteins, including G Protein Coupled Receptors (GPCRs) and ion channels.
Novoron Bioscience
Seed Round in 2022
Novoron Bioscience, Inc. is a biotechnology company based in San Diego, California, focused on developing innovative treatments for various central nervous system (CNS) disorders, including multiple sclerosis, spinal cord injury, glaucoma, and stroke. Founded in 2013, the company specializes in creating therapeutic approaches that target neurological damage and diseases using novel science centered on lipoprotein receptors. Novoron is advancing a pipeline of pre-clinical therapies aimed at addressing conditions such as Alzheimer's disease, tauopathies, and demyelinating diseases, with the goal of offering effective treatments for conditions that currently lack viable options. The company's research emphasizes repairing damage to the brain and spinal cord, ultimately striving to enhance recovery for patients suffering from debilitating neurological conditions.
Arch Systems
Venture Round in 2022
Arch Systems Inc. specializes in developing a device-to-cloud modular hardware platform tailored for industrial Internet of Things (IoT) applications, targeting the electronics and discrete manufacturing sectors. Founded in 2015 and headquartered in Mountain View, California, the company offers a comprehensive data analytics platform that integrates with both new and legacy machines across enterprise supply chains. This platform enables real-time and predictive analytics, helping manufacturers enhance operational efficiency and achieve significant improvements in machine utilization. Additionally, Arch Systems provides an extensive library of surface mount technology (SMT) machine connectors and collaborates with leading PCB manufacturing machine vendors, facilitating the digitization of both new and existing factories. Through its Arch Utilization Suite, the company empowers clients to make informed business decisions by delivering valuable insights and improving data accessibility.
CIQ
Series A in 2022
CIQ is an IT company that specializes in enterprise software solutions, focusing on secure hybrid orchestration for performance-intensive workflows. The company provides enterprise-grade support for leading industry-standard software, offering infrastructure solutions, security tools, and workflow automation. CIQ's software integrates the essential capabilities of enterprises, hyper-scale environments, cloud computing, and high-performance computing, facilitating intelligent and secure orchestration of workflows across multiple clouds and sites. This enables industries such as pharmaceuticals, government, military, and research to enhance the speed and efficiency of their multi-premise and multi-architecture operations.
Selector
Series A in 2022
Selector AI is a developer of an operational intelligence platform that focuses on managing multi-cloud infrastructures and performance-sensitive managed services. The platform utilizes AI and machine learning to analyze data from diverse sources, providing actionable insights that help network, cloud, and application operators meet their service KPIs. By enabling seamless collaboration through messaging platforms and offering search-driven querying, Selector AI enhances the user experience while automating data engineering processes. The platform also features automated anomaly detection and comparative analysis of metrics and events, empowering clients to leverage data science effectively to improve their infrastructure operations.
Novoron Bioscience
Seed Round in 2021
Novoron Bioscience, Inc. is a biotechnology company based in San Diego, California, focused on developing innovative treatments for various central nervous system (CNS) disorders, including multiple sclerosis, spinal cord injury, glaucoma, and stroke. Founded in 2013, the company specializes in creating therapeutic approaches that target neurological damage and diseases using novel science centered on lipoprotein receptors. Novoron is advancing a pipeline of pre-clinical therapies aimed at addressing conditions such as Alzheimer's disease, tauopathies, and demyelinating diseases, with the goal of offering effective treatments for conditions that currently lack viable options. The company's research emphasizes repairing damage to the brain and spinal cord, ultimately striving to enhance recovery for patients suffering from debilitating neurological conditions.
Novoron Bioscience
Convertible Note in 2021
Novoron Bioscience, Inc. is a biotechnology company based in San Diego, California, focused on developing innovative treatments for various central nervous system (CNS) disorders, including multiple sclerosis, spinal cord injury, glaucoma, and stroke. Founded in 2013, the company specializes in creating therapeutic approaches that target neurological damage and diseases using novel science centered on lipoprotein receptors. Novoron is advancing a pipeline of pre-clinical therapies aimed at addressing conditions such as Alzheimer's disease, tauopathies, and demyelinating diseases, with the goal of offering effective treatments for conditions that currently lack viable options. The company's research emphasizes repairing damage to the brain and spinal cord, ultimately striving to enhance recovery for patients suffering from debilitating neurological conditions.
Elisity
Series A in 2021
Elisity is a company focused on enhancing security for enterprise assets and data, addressing challenges arising from the complexities of modern work environments and mobile workforces. It has developed a cloud-based platform that utilizes least privilege access and identity-based micro-segmentation to secure network access. This platform continuously verifies user identity, location, permissions, and device behavior to provide granular access control, thereby enabling organizations to implement zero-trust security measures effectively. The team behind Elisity comprises experienced entrepreneurs with strong technical expertise in enterprise networking and security, leveraging their knowledge to cater to the needs of highly security-conscious organizations.
PulseData AI
Series A in 2021
PulseData AI, established in 2015 and headquartered in New York, specializes in healthcare technology. It develops machine learning software that helps healthcare providers identify patients at high risk of adverse, preventable medical outcomes. The company's platform analyzes vast amounts of patient data to predict health trends, enabling care management teams to deliver timely, targeted interventions and improve overall patient outcomes.
Graphiant
Series A in 2020
Graphiant Inc. is a technology company based in Silicon Valley, founded in 2020 and headquartered in Fremont, California. It specializes in developing software-defined wide area network (SD-WAN) solutions aimed at transforming enterprise networking. The company offers the Graphiant Network Edge, a software-as-a-service platform that facilitates seamless connectivity across enterprise WANs, hybrid clouds, network edges, and various clients and partners. Graphiant's technology combines the performance of traditional multiprotocol label switching with the agility of modern internet solutions, enabling network architects to design and implement enterprise-grade networks that keep pace with business demands.
TileDB
Series A in 2020
TileDB, Inc. develops and maintains a system for managing multi-dimensional array data, particularly suited for scientific applications. The company's offerings include TileDB Embedded, a storage engine, and TileDB Cloud, which facilitates the management of array data in the cloud. Designed to handle a variety of data types, including unstructured multimodal data, TileDB addresses the complexities encountered in fields such as genomics, biomedical imaging, and multiomic data analysis. This foundational software is utilized by research teams in pharmaceuticals and biotechnology to enhance their data platforms and drive scientific discovery. Founded in 2017 and headquartered in Cambridge, Massachusetts, TileDB also has a location in Athens, Greece.
Inimmune
Series A in 2020
Inimmune Corp. is a biotechnology company based in Missoula, Montana, founded in 2016. The company specializes in the discovery and development of innovative vaccines and immunotherapeutics aimed at treating and preventing various medical conditions. Inimmune's research focuses on optimizing innate immune receptor agonists and antagonists to address diseases such as cancer, allergic rhinitis, food allergies, autoimmune disorders, and infectious diseases. By targeting innate immune receptors, Inimmune aims to enhance the body’s immune response and offers potential solutions for upper respiratory tract infections and other health challenges.
Verafi
Seed Round in 2020
VERAFĪ operates as a SaaS-based platform focused on private intelligence and due diligence, aiming to enhance fraud prevention in various sectors. The company integrates human expertise from the intelligence community with advanced machine learning technology, catering to professionals in private equity, venture capital, and commercial credit. This approach allows users to access critical intelligence efficiently, facilitating a smoother deal flow process. By addressing the needs of the corporate and human diligence markets, VERAFĪ provides tools for effective KYC (Know Your Customer), enhanced due diligence, pre-employment screening, and fraud detection, thus promoting a more secure business environment.
Verafi
Pre Seed Round in 2019
VERAFĪ operates as a SaaS-based platform focused on private intelligence and due diligence, aiming to enhance fraud prevention in various sectors. The company integrates human expertise from the intelligence community with advanced machine learning technology, catering to professionals in private equity, venture capital, and commercial credit. This approach allows users to access critical intelligence efficiently, facilitating a smoother deal flow process. By addressing the needs of the corporate and human diligence markets, VERAFĪ provides tools for effective KYC (Know Your Customer), enhanced due diligence, pre-employment screening, and fraud detection, thus promoting a more secure business environment.
Graphiant
Graphiant Inc. is a technology company based in Silicon Valley, founded in 2020 and headquartered in Fremont, California. It specializes in developing software-defined wide area network (SD-WAN) solutions aimed at transforming enterprise networking. The company offers the Graphiant Network Edge, a software-as-a-service platform that facilitates seamless connectivity across enterprise WANs, hybrid clouds, network edges, and various clients and partners. Graphiant's technology combines the performance of traditional multiprotocol label switching with the agility of modern internet solutions, enabling network architects to design and implement enterprise-grade networks that keep pace with business demands.
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