Valence Life Sciences

CalciMedica is a biopharmaceutical company focused on developing therapeutics for inflammatory and autoimmune disorders. It specializes in discovering and developing small molecule drugs that target calcium release-activated calcium channels.

CalciMedica is a biopharmaceutical company focused on developing therapeutics for inflammatory and autoimmune disorders. It specializes in discovering and developing small molecule drugs that target calcium release-activated calcium channels.

JenaValve Technology, Inc. is a medical device company specializing in the design, development, and manufacturing of transcatheter aortic valve replacement (TAVR) systems for patients with severe aortic regurgitation and aortic stenosis. Founded in 2006 and headquartered in Irvine, California, with additional locations in Munich, Germany, and Leeds, United Kingdom, the company focuses on providing innovative solutions for high-risk patients who may not be suitable candidates for traditional surgical aortic valve replacement. The company's flagship product, the Trilogy™ Heart Valve System, received CE Mark approval in May 2021 and is notable for its dual-disease treatment capabilities. JenaValve's TAVR systems feature a porcine pericardial trileaflet valve mounted on a low-profile nitinol self-expanding frame, designed to engage with the native valve structures for optimal performance. The company has also received Breakthrough Device Designation from the U.S. Food and Drug Administration to facilitate the review of its pivotal trial for the Trilogy Heart Valve System in the United States.

Invuity is a medical technology company that develops visualization products for minimally invasive and open surgeries. Using photonics technology, it directs and shapes light to provide broad, uniform illumination and direct visualization inside dark surgical cavities, enabling enhanced precision, efficiency, and safety. The product line includes illuminated retractors and handheld and intracavity illumination systems used in breast, orthopedic, spine, neurosurgery, endocrine, gynecologic, colorectal, and general procedures. Examples include Eikon LT and Eiberg illuminated retractors, PhotonBlade and PhotonSaber handheld illuminators, Breiten retractors, Photonguide XT intracavity illuminator, and PhotonVue visualization with indocyanine green imaging. Devices come in single-use and reusable formats and are sold directly to hospitals, surgeons, and to third-party manufacturers. Founded in 2004 and based in San Francisco, Invuity originated as Spotlight Surgical.

Invuity is a medical technology company that develops visualization products for minimally invasive and open surgeries. Using photonics technology, it directs and shapes light to provide broad, uniform illumination and direct visualization inside dark surgical cavities, enabling enhanced precision, efficiency, and safety. The product line includes illuminated retractors and handheld and intracavity illumination systems used in breast, orthopedic, spine, neurosurgery, endocrine, gynecologic, colorectal, and general procedures. Examples include Eikon LT and Eiberg illuminated retractors, PhotonBlade and PhotonSaber handheld illuminators, Breiten retractors, Photonguide XT intracavity illuminator, and PhotonVue visualization with indocyanine green imaging. Devices come in single-use and reusable formats and are sold directly to hospitals, surgeons, and to third-party manufacturers. Founded in 2004 and based in San Francisco, Invuity originated as Spotlight Surgical.

Celator Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company dedicated to developing innovative therapies for cancer treatment. Utilizing its proprietary CombiPlex technology platform, the company designs and evaluates optimized drug combinations that integrate traditional chemotherapies with molecularly targeted agents to enhance anti-cancer efficacy. Notable products in its pipeline include VYXEOS, a nano-scale liposomal formulation of irinotecan and floxuridine, and CPX-351, a liposomal formulation of cytarabine and daunorubicin, both in Phase III clinical trials for acute myeloid leukemia. Additionally, CPX-1, a liposomal formulation of irinotecan and floxuridine, has completed Phase II studies for colorectal cancer. Celator also has a preclinical candidate, CPX-8, which is a hydrophobic docetaxel prodrug nanoparticle formulation. Founded in 1999 and headquartered in Ewing, New Jersey, Celator Pharmaceuticals operates as a subsidiary of Jazz Pharmaceuticals Public Limited Company.

Invuity is a medical technology company that develops visualization products for minimally invasive and open surgeries. Using photonics technology, it directs and shapes light to provide broad, uniform illumination and direct visualization inside dark surgical cavities, enabling enhanced precision, efficiency, and safety. The product line includes illuminated retractors and handheld and intracavity illumination systems used in breast, orthopedic, spine, neurosurgery, endocrine, gynecologic, colorectal, and general procedures. Examples include Eikon LT and Eiberg illuminated retractors, PhotonBlade and PhotonSaber handheld illuminators, Breiten retractors, Photonguide XT intracavity illuminator, and PhotonVue visualization with indocyanine green imaging. Devices come in single-use and reusable formats and are sold directly to hospitals, surgeons, and to third-party manufacturers. Founded in 2004 and based in San Francisco, Invuity originated as Spotlight Surgical.

Invuity is a medical technology company that develops visualization products for minimally invasive and open surgeries. Using photonics technology, it directs and shapes light to provide broad, uniform illumination and direct visualization inside dark surgical cavities, enabling enhanced precision, efficiency, and safety. The product line includes illuminated retractors and handheld and intracavity illumination systems used in breast, orthopedic, spine, neurosurgery, endocrine, gynecologic, colorectal, and general procedures. Examples include Eikon LT and Eiberg illuminated retractors, PhotonBlade and PhotonSaber handheld illuminators, Breiten retractors, Photonguide XT intracavity illuminator, and PhotonVue visualization with indocyanine green imaging. Devices come in single-use and reusable formats and are sold directly to hospitals, surgeons, and to third-party manufacturers. Founded in 2004 and based in San Francisco, Invuity originated as Spotlight Surgical.