Venrock

Surrozen, Inc. is a clinical-stage biopharmaceutical company based in South San Francisco, California, focused on developing targeted regenerative antibodies to repair damaged tissues and improve organ function. The company utilizes antibody platforms that act as Wnt and R-spondin mimetics to stimulate tissue regeneration in a variety of organs. Its key programs include SZN-043, which aims to promote hepatocyte regeneration in liver diseases, and SZN-1326, designed to repair diseased epithelial tissue for patients with inflammatory bowel disease. Surrozen's research targets several disease areas, including conditions affecting the intestine, liver, retina, cornea, lung, kidney, cochlea, skin, pancreas, and central nervous system, by engaging the body’s natural biological repair mechanisms. The company was incorporated in 2015 and continues to advance its innovative therapeutic approaches.

ORIC Pharmaceuticals is a clinical-stage biopharmaceutical company focused on developing therapies to overcome resistance in cancer treatments. Founded in 2014 and based in South San Francisco, the company’s lead product candidate, ORIC-101, is a small molecule antagonist of the glucocorticoid receptor, which is associated with resistance to various cancer therapies in solid tumors. Its second candidate, ORIC-533, is an orally bioavailable small molecule inhibitor of CD73, targeting a critical component of the adenosine pathway linked to resistance against chemotherapy and immunotherapy. In addition to these products, ORIC is advancing multiple precision medicines aimed at addressing other mechanisms of cancer resistance. The company’s founders, Charles Sawyers and Scott Lowe, have extensive experience in identifying novel cancer targets that have led to innovative therapies.

Graphite Bio, Inc. is a clinical-stage gene editing company based in South San Francisco, California, that specializes in targeted DNA integration to develop innovative therapies for severe diseases. The company utilizes a precision gene editing approach to precisely correct genetic mutations, replace malfunctioning genes, and insert therapeutic genetic sequences at specific locations within the genome. Its technology aims to transform treatment paradigms by enabling the targeted integration of genetic payloads, which could potentially cure a range of serious and life-threatening conditions. Graphite Bio was formerly known as Integral Medicines, Inc. before rebranding in August 2020, and it was incorporated in 2019.

Luma, Inc. designs and develops a platform for managing events, focusing on both virtual and in-person experiences. Founded in 2020 and based in San Francisco, California, the company offers a range of features, including ticket sales, attendance tracking, and analytics. Luma enables users to host virtual classes, record live shows, and connect with their communities through integrated tools. The platform supports event promotion and management, allowing users to send invitations and accept tips and memberships. Overall, Luma aims to enhance the event-hosting experience by providing a comprehensive suite of services for organizers and attendees alike.

Federation Bio Inc. is focused on developing microbial therapeutics aimed at curing various diseases through the human microbiome. The company utilizes platforms that harness naturally occurring or engineered bacteria, along with a supportive community of bacteria, to promote engraftment and achieve lasting therapeutic responses. Its research encompasses a broad spectrum of conditions, including secondary hyperoxaluria, metabolic disorders, immune diseases, cholestatic diseases, and cancer. Founded in 2018 and headquartered in South San Francisco, California, Federation Bio was previously known as Comet Medicine Inc. before rebranding in April 2019.

Concentric Analgesics, Inc. is a biopharmaceutical company dedicated to the discovery and development of non-opioid therapeutics for managing acute and chronic pain. Founded in 2014 and based in San Francisco, the company focuses on creating innovative pain relief solutions that require only a single local administration. Its pipeline includes several promising candidates: CA-008, an injectable prodrug of capsaicin designed for acute post-surgical pain; CA-051, intended for epidural use in treating refractory pain related to cancer or amputation; and an injection product aimed at alleviating chronic pain associated with moderate to severe osteoarthritis. Concentric Analgesics aims to target pain at its source while minimizing systemic exposure, thereby enhancing patient outcomes and simplifying ongoing care.

Tricida, Inc. is a late-stage pharmaceutical company based in South San Francisco, California, dedicated to the development and commercialization of its lead drug candidate, TRC101. This non-absorbed, orally-administered polymer is designed to treat metabolic acidosis, a condition often associated with chronic kidney disease (CKD). Metabolic acidosis can contribute to the progression of CKD and is linked to various health issues such as muscle wasting, loss of bone density, and increased mortality risk. Tricida has successfully completed a Phase 3, double-blind, placebo-controlled trial of TRC101, aiming to provide an effective treatment option for patients suffering from this condition. The company was founded in 2013 and is focused on addressing the unmet medical needs of individuals with CKD.

CytomX Therapeutics, Inc. is an oncology-focused biopharmaceutical company based in South San Francisco, California. It specializes in developing a novel class of antibody therapeutics utilizing its Probody technology platform, which aims to enhance the targeting of tumors while minimizing drug activity in healthy tissues. The company's clinical-stage product candidates include CX-072, a therapeutic targeting programmed cell death ligand 1; CX-2009, a drug conjugate targeting CD166; BMS-986249 and BMS-986288, both targeting CTLA-4 for metastatic melanoma and solid tumors; and CX-2029, a drug conjugate for CD71 in solid tumors. CytomX collaborates strategically with several industry leaders, including AbbVie, Amgen, and Bristol-Myers Squibb, to advance its Probody therapeutics. Founded in 2008, CytomX Therapeutics is committed to providing innovative and less toxic treatment options for patients with severe illnesses such as cancer.

Betable Limited is a gaming platform that allows developers to legally incorporate real-money gambling into their mobile and social games. Founded in 2008 and headquartered in London, with an additional office in San Francisco, Betable provides essential support, infrastructure, and licensing to facilitate this integration. The platform features a range of services, including the Betable engine, Betable Reach, and Betable Wallet, which help developers manage the processing, legality, and compliance associated with real-money gaming. Licensed by the United Kingdom Gambling Commission and the Alderney Gambling Control Commission, Betable prioritizes security and responsible gaming through robust fraud protection, player location verification, identity checks, and account monitoring. This enables developers to offer real-money play without the burden of extensive licensing costs or loss of control over their games.

Martini Media Network, Inc. is a digital media and content platform based in San Francisco, California, specializing in engaging affluent audiences. Founded in 2007, the company offers tailored solutions for brands to deliver media campaigns that integrate content, videos, and social functionality across niche sites. Martini Media focuses on invitation-only platforms centered around business and lifestyle categories, enabling effective engagement with influential consumers. By leveraging insights into online behaviors and interests of the affluent market, the company partners with clients and agencies to craft customized advertising, publishing, and storytelling programs that align with specific marketing objectives. As of June 2015, Martini Media operates as a subsidiary of Evolve Media, LLC.

SmartBiz Loans is the #1 online SBA loan marketplace for small business loans. The intelligent technology platform makes applying for an SBA loan fast and easy while increasing the likelihood of approval for small businesses by matching the borrower with the SBA preferred lending bank most likely to fund their particular business. 90% to 95% of the loans SmartBiz refers to its bank partners get funded. Bank partners using the SmartBiz platform to originate and underwriter SBA loans in a compliant manner can also process these loans 70% to 90% more efficiently then before. Based in the financial district of San Francisco, SmartBiz Loans is privately held. The company was founded in 2009 by a team of experienced financial services entrepreneurs with backing from leading venture capital firms including Investor Growth Capital, Venrock, First Round Capital, Baseline Ventures, and SoftTech VC.

Martini Media Network, Inc. is a digital media and content platform based in San Francisco, California, specializing in engaging affluent audiences. Founded in 2007, the company offers tailored solutions for brands to deliver media campaigns that integrate content, videos, and social functionality across niche sites. Martini Media focuses on invitation-only platforms centered around business and lifestyle categories, enabling effective engagement with influential consumers. By leveraging insights into online behaviors and interests of the affluent market, the company partners with clients and agencies to craft customized advertising, publishing, and storytelling programs that align with specific marketing objectives. As of June 2015, Martini Media operates as a subsidiary of Evolve Media, LLC.

SmartBiz Loans is the #1 online SBA loan marketplace for small business loans. The intelligent technology platform makes applying for an SBA loan fast and easy while increasing the likelihood of approval for small businesses by matching the borrower with the SBA preferred lending bank most likely to fund their particular business. 90% to 95% of the loans SmartBiz refers to its bank partners get funded. Bank partners using the SmartBiz platform to originate and underwriter SBA loans in a compliant manner can also process these loans 70% to 90% more efficiently then before. Based in the financial district of San Francisco, SmartBiz Loans is privately held. The company was founded in 2009 by a team of experienced financial services entrepreneurs with backing from leading venture capital firms including Investor Growth Capital, Venrock, First Round Capital, Baseline Ventures, and SoftTech VC.

SmartBiz Loans is the #1 online SBA loan marketplace for small business loans. The intelligent technology platform makes applying for an SBA loan fast and easy while increasing the likelihood of approval for small businesses by matching the borrower with the SBA preferred lending bank most likely to fund their particular business. 90% to 95% of the loans SmartBiz refers to its bank partners get funded. Bank partners using the SmartBiz platform to originate and underwriter SBA loans in a compliant manner can also process these loans 70% to 90% more efficiently then before. Based in the financial district of San Francisco, SmartBiz Loans is privately held. The company was founded in 2009 by a team of experienced financial services entrepreneurs with backing from leading venture capital firms including Investor Growth Capital, Venrock, First Round Capital, Baseline Ventures, and SoftTech VC.

Martini Media Network, Inc. is a digital media and content platform based in San Francisco, California, specializing in engaging affluent audiences. Founded in 2007, the company offers tailored solutions for brands to deliver media campaigns that integrate content, videos, and social functionality across niche sites. Martini Media focuses on invitation-only platforms centered around business and lifestyle categories, enabling effective engagement with influential consumers. By leveraging insights into online behaviors and interests of the affluent market, the company partners with clients and agencies to craft customized advertising, publishing, and storytelling programs that align with specific marketing objectives. As of June 2015, Martini Media operates as a subsidiary of Evolve Media, LLC.

BlogHer Inc., founded in 2005 and based in Redwood City, California, operates a prominent cross-platform media network focused on women in social media. The company publishes and syndicates a wide range of content, including news, information, advice, and recommendations across various topics such as food, family, fashion, health, and entertainment. BlogHer serves as a community for women bloggers, attracting approximately 55 million unique visitors monthly and facilitating the sharing of voices and ideas. The organization hosts the BlogHer Conferences, the largest conference for women in social media, and manages the BlogHer Publishing Network, which encompasses around 3,000 blogs authored by women. As a subsidiary of SheKnows, LLC, BlogHer is committed to empowering women through education, community, and economic opportunities, fostering a respectful environment for discussions on diverse subjects.

SmartBiz Loans is the #1 online SBA loan marketplace for small business loans. The intelligent technology platform makes applying for an SBA loan fast and easy while increasing the likelihood of approval for small businesses by matching the borrower with the SBA preferred lending bank most likely to fund their particular business. 90% to 95% of the loans SmartBiz refers to its bank partners get funded. Bank partners using the SmartBiz platform to originate and underwriter SBA loans in a compliant manner can also process these loans 70% to 90% more efficiently then before. Based in the financial district of San Francisco, SmartBiz Loans is privately held. The company was founded in 2009 by a team of experienced financial services entrepreneurs with backing from leading venture capital firms including Investor Growth Capital, Venrock, First Round Capital, Baseline Ventures, and SoftTech VC.

Martini Media Network, Inc. is a digital media and content platform based in San Francisco, California, specializing in engaging affluent audiences. Founded in 2007, the company offers tailored solutions for brands to deliver media campaigns that integrate content, videos, and social functionality across niche sites. Martini Media focuses on invitation-only platforms centered around business and lifestyle categories, enabling effective engagement with influential consumers. By leveraging insights into online behaviors and interests of the affluent market, the company partners with clients and agencies to craft customized advertising, publishing, and storytelling programs that align with specific marketing objectives. As of June 2015, Martini Media operates as a subsidiary of Evolve Media, LLC.

BlogHer Inc., founded in 2005 and based in Redwood City, California, operates a prominent cross-platform media network focused on women in social media. The company publishes and syndicates a wide range of content, including news, information, advice, and recommendations across various topics such as food, family, fashion, health, and entertainment. BlogHer serves as a community for women bloggers, attracting approximately 55 million unique visitors monthly and facilitating the sharing of voices and ideas. The organization hosts the BlogHer Conferences, the largest conference for women in social media, and manages the BlogHer Publishing Network, which encompasses around 3,000 blogs authored by women. As a subsidiary of SheKnows, LLC, BlogHer is committed to empowering women through education, community, and economic opportunities, fostering a respectful environment for discussions on diverse subjects.

SlideShare, Inc. is an online platform founded in 2006 and based in San Francisco, California, that facilitates the sharing and discovery of user-generated and professional content. It allows users to upload and share various types of content, including presentations, documents, infographics, and videos across a wide range of topics such as business, education, technology, health, and more. Users can engage with the content through ratings, comments, and sharing options. SlideShare serves professionals, educators, businesses, nonprofits, and government entities, enabling them to connect, share ideas, conduct research, and generate leads. As of August 2020, SlideShare operates as a subsidiary of Scribd, Inc. The platform has also announced plans to expand its offerings in educational materials through a collaboration with Certkillers.

BlogHer Inc., founded in 2005 and based in Redwood City, California, operates a prominent cross-platform media network focused on women in social media. The company publishes and syndicates a wide range of content, including news, information, advice, and recommendations across various topics such as food, family, fashion, health, and entertainment. BlogHer serves as a community for women bloggers, attracting approximately 55 million unique visitors monthly and facilitating the sharing of voices and ideas. The organization hosts the BlogHer Conferences, the largest conference for women in social media, and manages the BlogHer Publishing Network, which encompasses around 3,000 blogs authored by women. As a subsidiary of SheKnows, LLC, BlogHer is committed to empowering women through education, community, and economic opportunities, fostering a respectful environment for discussions on diverse subjects.

Biospect, Inc. is a life sciences technology company based in South San Francisco, California, focused on developing minimally invasive methods for identifying and analyzing protein biomarker patterns that indicate and differentiate various biological states. The company's integrated system combines proprietary technologies for separations, detection, and informatics, facilitating applications in disease diagnosis, management, and drug development. Biospect's innovations aim to assist medical researchers in their efforts to improve health outcomes and enhance the efficiency of therapeutic interventions. The company is supported by notable investors, including Advent Venture Partners, Prospect Venture Partners, Venrock Associates, and Versant Ventures.

CytomX Therapeutics, Inc. is an oncology-focused biopharmaceutical company based in South San Francisco, California. It specializes in developing a novel class of antibody therapeutics utilizing its Probody technology platform, which aims to enhance the targeting of tumors while minimizing drug activity in healthy tissues. The company's clinical-stage product candidates include CX-072, a therapeutic targeting programmed cell death ligand 1; CX-2009, a drug conjugate targeting CD166; BMS-986249 and BMS-986288, both targeting CTLA-4 for metastatic melanoma and solid tumors; and CX-2029, a drug conjugate for CD71 in solid tumors. CytomX collaborates strategically with several industry leaders, including AbbVie, Amgen, and Bristol-Myers Squibb, to advance its Probody therapeutics. Founded in 2008, CytomX Therapeutics is committed to providing innovative and less toxic treatment options for patients with severe illnesses such as cancer.

ORIC Pharmaceuticals is a clinical-stage biopharmaceutical company focused on developing therapies to overcome resistance in cancer treatments. Founded in 2014 and based in South San Francisco, the company’s lead product candidate, ORIC-101, is a small molecule antagonist of the glucocorticoid receptor, which is associated with resistance to various cancer therapies in solid tumors. Its second candidate, ORIC-533, is an orally bioavailable small molecule inhibitor of CD73, targeting a critical component of the adenosine pathway linked to resistance against chemotherapy and immunotherapy. In addition to these products, ORIC is advancing multiple precision medicines aimed at addressing other mechanisms of cancer resistance. The company’s founders, Charles Sawyers and Scott Lowe, have extensive experience in identifying novel cancer targets that have led to innovative therapies.