WuXi Healthcare Ventures

Adlai Nortye Biopharma Co., Ltd. is a clinical-stage biopharmaceutical company based in Hangzhou, China, specializing in the research and development of innovative oncology therapies. Founded in 2004 and formerly known as Sinopep Pharmaceutical Inc., the company focuses on developing cancer treatments and addressing metabolic diseases. Adlai Nortye operates R&D and clinical operation centers in both China and the United States, emphasizing its global approach to drug development. The company has established a robust pipeline featuring over ten drug candidates, including those in various stages of clinical and preclinical development, such as buparlisib, palupiprant, and AN4005. Through collaborations and internal discoveries, Adlai Nortye seeks to advance its goal of providing effective treatment options for patients with a wide range of tumor types.

Zenas BioPharma is a clinical-stage biopharmaceutical company focused on developing immune-based therapies for autoimmune and immune-mediated diseases. Based in Florida, United States, the company advances biologic programs and aims to modulate B cell–driven pathology. Its lead product candidate, obexelimab, is a bifunctional monoclonal antibody designed to bind both CD19 and FcγRIIb on B cells, thereby inhibiting harmful immune activity without depleting B cells.

LifeMine Therapeutics, Inc. is a biotechnology company focused on the genomic discovery of new drug modalities derived from eukaryotic microbes, specifically fungi. Founded in 2016 and headquartered in Cambridge, Massachusetts, with an additional office in New York, it employs an integrated drug discovery platform that combines genomics, artificial intelligence, and synthetic biology. LifeMine’s Avatar-Rx platform utilizes high-throughput microbiology, data science, genome engineering, and automation technologies to identify novel gene-encoded molecules (GEMs) with specific biological functions. The company emphasizes chemoinformatic-assisted drug optimization and advanced chemical synthesis, enabling the progression of new product candidates into development. Founded by experts in the field, LifeMine Therapeutics aims to innovate medicine through its unique approach to leveraging the fungal biosphere.

XW Laboratories Inc. is a biopharmaceutical company based in Wuhan, China, specializing in the development of innovative treatments for neurological disorders. Founded in 2014, the company has established three distinct research and development platforms, including Prodrug and Functional Group Switch, which facilitate the rapid identification of novel drug candidates while minimizing development costs and time. The company is committed to creating medications that enhance patient compliance and reduce toxicity. Additionally, XW Laboratories is advancing its capabilities in immunoneurology through a mitochondria-targeting platform. While primarily focused on the Chinese market, the company also engages in collaborations to reach foreign markets, aiming to transform the quality of life for patients suffering from neurological conditions.

Halda Therapeutics is a research-stage drug discovery company dedicated to developing next-generation precision medicine. The company employs a unique therapeutic modality that serves as a platform for addressing various disease states. By focusing on the discovery of novel therapies that modify disease-causing pathways, Halda Therapeutics aims to enable healthcare providers to offer more targeted treatments for their patients. Through its innovative approach, the company seeks to advance the field of precision medicine and improve patient outcomes.

Antengene Corporation is a clinical-stage biopharmaceutical company based in Shanghai, China, founded in 2016. The company specializes in the development of innovative oncology therapies, focusing on treatments for various types of cancers, including hematologic malignancies and solid tumors. Antengene's product portfolio includes ATG-010 (selinexor), which targets XPO1 for treating multiple myeloma and DLBCL, and ATG-008 (onatasertib), an mTOR kinase inhibitor for advanced solid tumors. The company’s pipeline also features several compounds in various stages of development, such as ATG-016, ATG-527, ATG-019, and ATG-017, each targeting specific cancer pathways. In addition to its clinical programs, Antengene is involved in the discovery, development, manufacturing, and commercialization of first-in-class therapeutics, aiming to address unmet medical needs in the oncology field across Asia.

Refuge Biotechnologies, Inc. is a biotechnology company focused on developing innovative cancer immunotherapies. Founded in 2015 and based in Menlo Park, California, the company utilizes advanced gene-editing technology, specifically CRISPR-dCas, to create cell therapies that are capable of sensing their environment and conditionally regulating multiple genes at once. This approach enables Refuge to enhance the potency and specificity of its treatments, allowing for more effective targeting of cancer cells compared to traditional therapies that focus on a single target. Through its research and development efforts, Refuge aims to unlock the full potential of cell therapies in the fight against cancer.

Unity Biotechnology is a biotechnology company dedicated to developing therapeutics that prevent, halt, or reverse age-related diseases. Its primary focus involves targeting senescent cells, designing senolytic medicines to clear these cells from the body while leaving normal cells unaffected. The company's pipeline includes UBX1325 for age-related eye diseases like diabetic macular edema.

IDEAYA Biosciences is an oncology-focused biotechnology company dedicated to discovering targeted therapeutics for patient populations selected using molecular diagnostics. Its pipeline includes small molecule inhibitors targeting DNA damage and repair pathways, such as MAT2A, PARG, and Pol-theta, as well as immuno-oncology therapies targeting the tumor microenvironment.

Medeor Therapeutics, Inc. is a biotechnology company focused on researching, developing, and commercializing innovative cellular immunotherapies aimed at enhancing outcomes for organ transplant recipients. Based in San Mateo, California, Medeor Therapeutics has developed a specialized immunotherapy product for kidney transplant recipients known as MDR-10X. The company's cellular immunotherapies target organ transplant immune tolerance and immuno-oncology, providing healthcare providers with advanced techniques to preserve or improve kidney function and mitigate the risk of graft rejection more effectively than traditional immunosuppression therapies. Incorporated in 2012, Medeor Therapeutics is dedicated to transforming transplant outcomes through personalized treatment strategies.

XW Laboratories Inc. is a biopharmaceutical company based in Wuhan, China, specializing in the development of innovative treatments for neurological disorders. Founded in 2014, the company has established three distinct research and development platforms, including Prodrug and Functional Group Switch, which facilitate the rapid identification of novel drug candidates while minimizing development costs and time. The company is committed to creating medications that enhance patient compliance and reduce toxicity. Additionally, XW Laboratories is advancing its capabilities in immunoneurology through a mitochondria-targeting platform. While primarily focused on the Chinese market, the company also engages in collaborations to reach foreign markets, aiming to transform the quality of life for patients suffering from neurological conditions.

LifeMine Therapeutics, Inc. is a biotechnology company focused on the genomic discovery of new drug modalities derived from eukaryotic microbes, specifically fungi. Founded in 2016 and headquartered in Cambridge, Massachusetts, with an additional office in New York, it employs an integrated drug discovery platform that combines genomics, artificial intelligence, and synthetic biology. LifeMine’s Avatar-Rx platform utilizes high-throughput microbiology, data science, genome engineering, and automation technologies to identify novel gene-encoded molecules (GEMs) with specific biological functions. The company emphasizes chemoinformatic-assisted drug optimization and advanced chemical synthesis, enabling the progression of new product candidates into development. Founded by experts in the field, LifeMine Therapeutics aims to innovate medicine through its unique approach to leveraging the fungal biosphere.

Founded in 2014, Vivace Therapeutics is a biotechnology company based in the San Francisco Bay Area. It focuses on discovering and developing cancer therapeutics by targeting novel pathways, with a particular emphasis on the Hippo pathway which controls tissue regeneration and organ size.

Ivenix, Inc. is a medical technology company based in North Andover, Massachusetts, specializing in the development of advanced intravenous (IV) infusion systems. Founded in 2001 and originally known as Fluidnet Corporation, Ivenix offers a next-generation infusion management platform that utilizes pneumatic technology to enhance the accuracy of fluid delivery. This innovative system is designed to measure and control flow regardless of factors such as bag height, backpressure, patient movement, and fluid viscosity. Additionally, the platform manages patient infusion data and integrates seamlessly with clinical information systems, ensuring precise and continuous infusion delivery in hospital settings. Ivenix aims to revolutionize infusion therapy worldwide by combining state-of-the-art information technology with user-friendly design, thereby improving patient care and safety.

Forerunner Medical (Shanghai) Co., Ltd., established in 2009, specializes in the development and manufacturing of innovative medical devices aimed at minimally invasive treatments. The company focuses on creating low-temperature plasma radio-frequency generators and electrodes specifically designed for sports medicine and tumor treatment. By leveraging extensive domestic clinical data and advanced technology, Forerunner Medical aims to meet both domestic and global healthcare needs. The organization emphasizes the quality and safety of its products, ensuring high performance, aesthetic appeal, and user convenience. Its commitment to excellence is reflected in its state-of-the-art production equipment and professional expertise, which contribute to its competitive advantage in the medical device industry.

TenNor Therapeutics is a clinical-stage product development company dedicated to addressing unmet medical needs in the field of infectious diseases. The company utilizes a dual-acting drug discovery platform to advance a portfolio of innovative products currently in various stages of preclinical and clinical development. TenNor focuses on developing new treatments for complications arising from Helicobacter pylori infections, prosthetic joint infections, and multidrug-resistant Gram-negative infections, among other significant infectious diseases. Additionally, the company's multi-targeting approach aims to offer solutions for gastrointestinal tract infections, medical device infections, and bacterial dysbiosis, thereby providing new therapeutic options for conditions that lack effective treatments.

Nutrinia Ltd. is a neonatology company focused on developing pharmaceuticals to address rare gastrointestinal conditions in infants. Based in Ramat-Gan, Israel, the company has created oral formulations of insulin designed to enhance gut adaptation and rehabilitation in premature infants and children. Its key clinical programs include NTRA-2112, which aims to reduce enteral nutrition intolerance, promote growth velocity and weight gain, and decrease the length of stay in neonatal intensive care units. Another significant product, NTRA-9620, targets short bowel syndrome by improving bowel adaptation post-resection, facilitating enteral nutrition, and minimizing the reliance on parenteral nutrition. Founded in 2003, Nutrinia is committed to improving the health outcomes of vulnerable populations through innovative scientific solutions.

Avelas Biosciences is focused on advancing cancer surgery through innovative intraoperative imaging technology. The company has developed a proprietary platform that utilizes activatable cell-penetrating peptides to provide real-time diagnosis of metastatic nodes during surgical procedures. This technology enables oncologic surgeons to create a luminous map of the surgical area, improving their ability to identify and remove cancerous tissue effectively. By enhancing surgical precision, Avelas Biosciences aims to reduce the need for repeat surgeries and ultimately improve patient outcomes, establishing a new standard of care in oncological surgery.

CStone Pharmaceuticals, founded in 2015, focuses on developing and commercializing innovative immunotherapy and precision treatment drugs for cancer patients worldwide. Its pipeline comprises over a dozen candidates targeting various indications, with immuno-oncology at its core.

IDEAYA Biosciences is an oncology-focused biotechnology company dedicated to discovering targeted therapeutics for patient populations selected using molecular diagnostics. Its pipeline includes small molecule inhibitors targeting DNA damage and repair pathways, such as MAT2A, PARG, and Pol-theta, as well as immuno-oncology therapies targeting the tumor microenvironment.

Hua Medicine is a clinical-stage drug development company in China focused on therapies for diabetes and CNS disorders. It develops Dorzagliatin (also known as HMS5552), an oral, first-in-class glucokinase activator for type 2 diabetes, and has advanced Dorzagliatin into NDA-enabling work and Phase III trials in China, including studies in drug-naive and metformin-treated patients. The company is pursuing Dorzagliatin in combination with metformin and in combination with DPP-4 inhibitors, SGLT-2 inhibitors, and insulin in various development stages. In addition, Hua Medicine is developing mGluR5 candidates for Parkinson's disease and related levodopa-induced dyskinesia. The company was founded in 2011 and is headquartered in Shanghai, China.

Adagene is a clinical-stage biotechnology company focused on developing immuno-oncology antibodies targeting novel epitopes. It employs its proprietary Smart Antibody Technology to enhance success rates, expedite time to market, and reduce development costs for therapeutic antibodies.

Forerunner Medical (Shanghai) Co., Ltd., established in 2009, specializes in the development and manufacturing of innovative medical devices aimed at minimally invasive treatments. The company focuses on creating low-temperature plasma radio-frequency generators and electrodes specifically designed for sports medicine and tumor treatment. By leveraging extensive domestic clinical data and advanced technology, Forerunner Medical aims to meet both domestic and global healthcare needs. The organization emphasizes the quality and safety of its products, ensuring high performance, aesthetic appeal, and user convenience. Its commitment to excellence is reflected in its state-of-the-art production equipment and professional expertise, which contribute to its competitive advantage in the medical device industry.

Founded in 2013, Twist Bioscience specializes in manufacturing and selling synthetic DNA-based products. Its innovative silicon-based DNA Synthesis Platform enables rapid, precise, high-throughput synthesis of DNA, serving customers in healthcare, agriculture, industrial chemicals, and data storage sectors.

Syros Pharmaceuticals, Inc. is a biopharmaceutical company based in Cambridge, Massachusetts, that specializes in developing innovative treatments for cancer and monogenic diseases through gene control medicines. The company is advancing its lead product candidates, including SY-1425, a selective retinoic acid receptor alpha agonist currently in Phase II clinical trials for specific patient populations with acute myeloid leukemia and myelodysplastic syndrome, and SY-5609, a cyclin-dependent kinase 7 inhibitor under investigation in a Phase I clinical trial for advanced solid tumors. Syros is also engaged in collaborative research, including a partnership with Incyte Corporation aimed at identifying therapeutic targets for myeloproliferative neoplasms and a licensing agreement with TMRC Co. Ltd. for the development of tamibarotene. With a focus on mapping gene regulatory circuits, Syros leverages its proprietary platform and expertise to address significant unmet medical needs in oncology. Founded in 2011, the company aims to establish new standards of care for patients with hematologic malignancies.

Refuge Biotechnologies, Inc. is a biotechnology company focused on developing innovative cancer immunotherapies. Founded in 2015 and based in Menlo Park, California, the company utilizes advanced gene-editing technology, specifically CRISPR-dCas, to create cell therapies that are capable of sensing their environment and conditionally regulating multiple genes at once. This approach enables Refuge to enhance the potency and specificity of its treatments, allowing for more effective targeting of cancer cells compared to traditional therapies that focus on a single target. Through its research and development efforts, Refuge aims to unlock the full potential of cell therapies in the fight against cancer.

AltheaDx, Inc. is a molecular diagnostics company based in San Diego, California, specializing in pharmacogenetics. The company utilizes an algorithm-based bioinformatics platform and a portfolio of pharmacogenetic testing products to assist healthcare providers in identifying the most suitable medications and dosage guidelines tailored to patients' genetic profiles and existing prescriptions. AltheaDx's IDgenetix test facilitates personalized therapeutic decisions for patients with common clinical conditions, including cardiovascular disease and neuropsychiatric disorders. Additionally, the company offers research and development services that encompass molecular biomarker discovery, assay development, and clinical trial testing, aimed at supporting diagnostic development for pharmaceutical, biotech, and medical device companies. AltheaDx serves a diverse range of clients, including long-term care facilities, government organizations, integrated delivery networks, and physicians. Founded in 1998, AltheaDx has established itself as a key player in the field of personalized medicine.

Lumo Bodytech, founded in 2011 and based in Mountain View, California, develops a technology platform that uses smart sensors and software to optimize human performance and address biomechanics through real-time tracking of body movement. The company offers products such as the Lumo Lift posture coach and activity tracker, and the Lumo Run sensor, which measures and coaches users on running form. Additionally, Lumo provides the Lumo MotionScience platform that delivers feedback on human movement. These products are sold online, through other online retailers in the United States, international distribution partners, and professional business retailers.

Founded in 2006, 23andMe is a biotechnology company specializing in direct-to-consumer genetic testing. It offers DNA analysis services through home-based saliva collection kits, providing insights into ancestry, traits, and health risks.

Tunitas Therapeutics, Inc. is a biopharmaceutical company based in San Francisco, California, focused on developing innovative protein therapeutics for allergy sufferers. Founded in 2007, the company specializes in creating genetically engineered fusion proteins, including its lead product, Epsi-gam, which combines human IgE and IgG1 components. These therapeutics aim to target and inhibit key pathways involved in allergic reactions, thereby disrupting the production of IgE, the antibody responsible for triggering allergic responses. Tunitas Therapeutics seeks to provide patients with effective treatment options for various IgE-mediated diseases, such as asthma and severe food allergies, through a regimen administered in their allergists’ offices. The company's mission is to significantly improve the quality of life for individuals suffering from serious allergic conditions.

Ivenix, Inc. is a medical technology company based in North Andover, Massachusetts, specializing in the development of advanced intravenous (IV) infusion systems. Founded in 2001 and originally known as Fluidnet Corporation, Ivenix offers a next-generation infusion management platform that utilizes pneumatic technology to enhance the accuracy of fluid delivery. This innovative system is designed to measure and control flow regardless of factors such as bag height, backpressure, patient movement, and fluid viscosity. Additionally, the platform manages patient infusion data and integrates seamlessly with clinical information systems, ensuring precise and continuous infusion delivery in hospital settings. Ivenix aims to revolutionize infusion therapy worldwide by combining state-of-the-art information technology with user-friendly design, thereby improving patient care and safety.

Hua Medicine is a clinical-stage drug development company in China focused on therapies for diabetes and CNS disorders. It develops Dorzagliatin (also known as HMS5552), an oral, first-in-class glucokinase activator for type 2 diabetes, and has advanced Dorzagliatin into NDA-enabling work and Phase III trials in China, including studies in drug-naive and metformin-treated patients. The company is pursuing Dorzagliatin in combination with metformin and in combination with DPP-4 inhibitors, SGLT-2 inhibitors, and insulin in various development stages. In addition, Hua Medicine is developing mGluR5 candidates for Parkinson's disease and related levodopa-induced dyskinesia. The company was founded in 2011 and is headquartered in Shanghai, China.

Founded in 2014, Vivace Therapeutics is a biotechnology company based in the San Francisco Bay Area. It focuses on discovering and developing cancer therapeutics by targeting novel pathways, with a particular emphasis on the Hippo pathway which controls tissue regeneration and organ size.

Unity Biotechnology is a biotechnology company dedicated to developing therapeutics that prevent, halt, or reverse age-related diseases. Its primary focus involves targeting senescent cells, designing senolytic medicines to clear these cells from the body while leaving normal cells unaffected. The company's pipeline includes UBX1325 for age-related eye diseases like diabetic macular edema.

Adagene is a clinical-stage biotechnology company focused on developing immuno-oncology antibodies targeting novel epitopes. It employs its proprietary Smart Antibody Technology to enhance success rates, expedite time to market, and reduce development costs for therapeutic antibodies.

Syros Pharmaceuticals, Inc. is a biopharmaceutical company based in Cambridge, Massachusetts, that specializes in developing innovative treatments for cancer and monogenic diseases through gene control medicines. The company is advancing its lead product candidates, including SY-1425, a selective retinoic acid receptor alpha agonist currently in Phase II clinical trials for specific patient populations with acute myeloid leukemia and myelodysplastic syndrome, and SY-5609, a cyclin-dependent kinase 7 inhibitor under investigation in a Phase I clinical trial for advanced solid tumors. Syros is also engaged in collaborative research, including a partnership with Incyte Corporation aimed at identifying therapeutic targets for myeloproliferative neoplasms and a licensing agreement with TMRC Co. Ltd. for the development of tamibarotene. With a focus on mapping gene regulatory circuits, Syros leverages its proprietary platform and expertise to address significant unmet medical needs in oncology. Founded in 2011, the company aims to establish new standards of care for patients with hematologic malignancies.

Avelas Biosciences is focused on advancing cancer surgery through innovative intraoperative imaging technology. The company has developed a proprietary platform that utilizes activatable cell-penetrating peptides to provide real-time diagnosis of metastatic nodes during surgical procedures. This technology enables oncologic surgeons to create a luminous map of the surgical area, improving their ability to identify and remove cancerous tissue effectively. By enhancing surgical precision, Avelas Biosciences aims to reduce the need for repeat surgeries and ultimately improve patient outcomes, establishing a new standard of care in oncological surgery.

IMPACT Therapeutics, Inc. is a biopharmaceutical company dedicated to the discovery, development, and commercialization of innovative therapeutics for cancer and other life-threatening diseases. Founded in 2009 and based in Shanghai, China, the company focuses on creating targeted anti-cancer treatments utilizing synthetic lethality. IMPACT Therapeutics is actively engaged in several research and development projects, including a PARP inhibitor, a Wee1 inhibitor, and various novel agents targeting DNA damage response mechanisms and the Hedgehog signaling pathway. Through its commitment to advancing treatment options, IMPACT Therapeutics aims to provide patients with effective and targeted anti-cancer therapies.

Hua Medicine is a clinical-stage drug development company in China focused on therapies for diabetes and CNS disorders. It develops Dorzagliatin (also known as HMS5552), an oral, first-in-class glucokinase activator for type 2 diabetes, and has advanced Dorzagliatin into NDA-enabling work and Phase III trials in China, including studies in drug-naive and metformin-treated patients. The company is pursuing Dorzagliatin in combination with metformin and in combination with DPP-4 inhibitors, SGLT-2 inhibitors, and insulin in various development stages. In addition, Hua Medicine is developing mGluR5 candidates for Parkinson's disease and related levodopa-induced dyskinesia. The company was founded in 2011 and is headquartered in Shanghai, China.