20/20 HealthCare Partners

Variantyx Inc. is a biotechnology company based in Framingham, Massachusetts, founded in 2014. The company specializes in diagnostic testing for rare disorders through its whole genome sequencing (WGS) platform, known as Genomic Unity®. This innovative test analyzes a single patient sample to identify and report all major variant types, including small sequence changes, structural variants, mitochondrial variants, and short tandem repeat expansions. By providing a comprehensive approach to genetic testing, Variantyx eliminates the need for traditional, step-wise genetic testing methods. The platform is designed to generate clinical reports that help hospitals and commercial laboratories accurately understand a patient's genetic makeup, leading to improved diagnosis and optimized treatment recommendations for inherited disorders.

Coagulo Medical Technologies, Inc. develops testing systems that detects, identifies, and quantifies the effect of all anticoagulants in whole blood and communicates actionable results to healthcare providers. The company is based in Auburndale, Massachusetts.

XRHealth Ltd. is a medical technology company based in Tel Aviv, Israel, that specializes in developing virtual reality (VR) software solutions for therapeutic purposes. Founded in 2016, the company offers a range of products, including VRPhysio for physical therapy, VRReliever for pain management, and VRCogni for improving motor functions in patients recovering from strokes or dealing with cognitive impairments. Their platform also includes VRPsyc for treating mental health disorders and VRCoordi to enhance coordination skills in individuals with various conditions. XRHealth’s solutions integrate immersive technology with data analytics and remote monitoring, allowing patients to receive comprehensive care from home while enabling clinicians to track progress effectively. Recognized as a pioneer in the field, XRHealth is the first certified VR medical company with FDA/CE registered applications, focusing on diverse aspects of health assessment and treatment, including cognitive, physical, psychological, and pain management.

EnClear Therapies, Inc. is a life sciences company based in Newburyport, Massachusetts, focused on developing device-based therapies for neurodegenerative diseases. The company specializes in the delivery and monitoring of cerebrospinal fluid (CSF) and has created a proprietary therapeutic platform aimed at removing toxic proteins from the CSF. EnClear's products are primarily designed to improve the lives of patients suffering from conditions such as Amyotrophic Lateral Sclerosis (ALS) and Progressive Supranuclear Palsy (PSP). By providing innovative solutions in the treatment of these neurological diseases, EnClear Therapies aims to help halt disease progression and extend patient lifespans.

Verseau is creating a new class of therapeutics, macrophage checkpoint modulators, to benefit patients with cancer, immune and inflammatory diseases. The company's modulators identify novel targets and develop therapies that shift macrophages between immune activators and silencers in disease, enabling physicians to benefit patients from immunotherapy.

SQZ Biotechnologies Company is a clinical-stage biotechnology firm based in Watertown, Massachusetts, focused on developing innovative cell therapies for cancer and other serious diseases. Its primary product candidate, SQZ-PBMC-HPV, is currently undergoing Phase I clinical trials as both a standalone treatment and in combination with other immuno-oncology agents for HPV16+ advanced or metastatic solid tumors. The company utilizes its proprietary CellSqueeze technology to deliver various materials into patient cells, aiming to engineer the immune system for both activation and suppression. Additionally, SQZ Biotech is advancing multiple platforms, including SQZ Activating Antigen Carriers and SQZ Tolerizing Antigen Carriers, to address diverse clinical challenges. Established in 2013, the company is dedicated to transforming cell therapies through internal research and strategic partnerships.

EightSpokes, Inc. offers a SaaS platform that solves the problem of launch delays by implementing the Enlighten launch management software to replace the manual planning, coordination, and communication problems that occur. The company was incorporated in 2012 and is based in Lexington, Massachusetts.

Physiq, Inc. is a health technology company based in Chicago, Illinois, that specializes in personalized physiology analytics through its cloud-based predictive platform. The company has developed VitaLink, a remote patient monitoring interface that equips clinicians with insights into the health status of patients with chronic illnesses while in an ambulatory setting. Its technology processes various data streams to establish an individual's normal baseline, enabling the detection of significant changes in vital signs that may indicate impending medical events. This personalized approach allows healthcare providers to manage patient care more effectively and empowers individuals to take charge of their health and fitness. Additionally, Physiq's platform can be integrated into monitoring devices from other manufacturers, enhancing their capabilities. Founded in 2013 and initially known as VGBio, Inc., Physiq operates in both regulated healthcare and the health and fitness markets.

A solar panel that tracks the sun throughout the day produces up to 30% more electricity than one that does not. Solar project developers install single-axis tracking for most utility-scale sites, balancing upfront costs versus electricity revenues to maximize rates of return. QBotix disrupts today's cost curve of fixed-tilt, single-axis tracking, and dual-axis tracking with an innovative tracking solution that offers dual-axis tracking at single-axis price. This reduces the levelized cost of energy by 10-20% while providing the added benefit of higher reliability and system intelligence.

Velocomp is a sports technology company that offers a range of power measurement tools for bicycles worldwide. Its products include iSport, a wireless cycling computer and power meter; iPro, a product which helps in tracking progress and analyzing rides; iBike POWERHOUSE, a cycling computer that automatically adjusts to exercise goals; iAero, a product which helps in power and wind tunnel measurements; iDash CC, a cycling computer; iDash CC Deluxe, a fitness computer; iDash +Power, a dashboard for training and fitness; and protective bicycle cases and mounts for iPhone and iPod touch.

Zixi is the leading enabler of flawless broadcast quality HDTV over the Internet. Broadcasters, enterprises and video-on-demand services use Zixi to enrich user experience, create new services and significantly reduce costs. Zixi enables the delivery of live and on-demand HD video content over the Internet in real time and with unprecedented quality. The technology is applicable for multi-media delivery and consumption across a spectrum of industries.