AssetWatch specializes in proactive and predictive maintenance solutions aimed at preventing unplanned downtime for global manufacturers. The company offers an extensive remote condition monitoring service that integrates wireless sensors and communication hubs with sophisticated software. These wireless vibration and temperature sensors gather critical machine health data, which is analyzed using machine learning algorithms and the expertise of condition monitoring engineers. This analysis provides actionable insights that go beyond simple pass/fail assessments, enabling manufacturers to transition from a reactive to a proactive maintenance culture. By delivering prescriptive recommendations, AssetWatch supports manufacturers in optimizing their maintenance processes and enhancing operational reliability.
Virtue AI operates as an AI security and compliance platform for applications.
Virtue AI operates as an AI security and compliance platform for applications.
Atsena Therapeutics is a clinical-stage gene therapy company focused on developing treatments for inherited retinal diseases that can lead to blindness. Their clinical pipeline includes therapies for conditions such as X-linked retinoschisis and GUCY2D-associated Leber congenital amaurosis. Atsena employs an adeno-associated virus (AAV) technology platform, including a novel spreading capsid, to specifically target these retinal disorders. The company aims to prevent vision loss caused by genetic mutations through innovative ocular gene therapy solutions. With a commitment to advancing treatments for some of the most challenging forms of inherited retinal disease, Atsena Therapeutics seeks to improve the lives of patients affected by these conditions.
MicroTransponder, Inc. is a medical device company based in Austin, Texas, specializing in the development and commercialization of neurostimulation devices aimed at treating neurological disorders. Founded in 2007, the company focuses on therapies that utilize vagus nerve stimulation to address conditions such as tinnitus, chronic pain, and rehabilitation following strokes. Its flagship product, Vivistim, has received FDA approval for use in ischemic stroke survivors experiencing moderate to severe upper limb impairment. MicroTransponder's innovative approaches, which include paired vagus nerve stimulation and wireless neurostimulation systems, are designed to enhance recovery and improve quality of life for patients facing various neurological challenges.
Overland AI specializes in the development of autonomous navigation technology tailored for off-road vehicles. The company focuses on creating artificial intelligence-based solutions that enhance off-road autonomy, particularly for mission-critical sectors such as defense and national security. By utilizing machine learning and robotic systems, Overland AI provides modular software designed to facilitate the autonomous navigation of unimproved roads and rugged terrain. This technology enables clients to operate vehicles independently in challenging environments like mines, construction sites, and disaster zones, addressing the need for reliable transportation solutions in demanding conditions.
VeraDermics is a dermatology company focused on developing innovative solutions for skin conditions, particularly warts. The company has created a dissolvable microneedle patch that delivers immunotherapy painlessly, stimulating the body's immune response to combat the wart virus. This patch is designed to be applied like a bandage and remains on the skin for less than an hour. During this time, the microneedles, made from immune stimulators embedded in a polymer matrix, dissolve and are implanted into the skin. After the adhesive backing is removed, the microneedles continue to dissolve over the following weeks, releasing immune stimulators directly into the wart. This method not only provides a pain-free treatment option but also simplifies the administration process for medical practitioners and enhances patient comfort.
Xscape Photonics specializes in the development of photonic chips aimed at enhancing bandwidth connections within high-performance computing systems and data centers. By leveraging photonics technology, the company focuses on creating scalable, high-bandwidth solutions that are both energy-efficient and cost-effective. These chips facilitate improved connectivity among computing elements, significantly reducing power consumption while increasing the speed and efficiency of communications. Xscape Photonics' innovations support the advancement of applications in artificial intelligence, machine learning, and simulation hardware, positioning the company as a key player in the evolution of next-generation computing infrastructure.
Quantum Circuits, Inc. specializes in the development and manufacture of quantum computers utilizing superconducting devices. Founded in 2015 and located in New Haven, Connecticut, the company aims to innovate in the field of quantum computing by delivering full-stack systems that efficiently scale. Led by Dr. Robert Schoelkopf, a prominent figure in quantum science, Quantum Circuits employs a unique dual-rail quantum qubit design that incorporates built-in hardware error detection and conversion. This approach allows for a highly scalable error-corrected system, requiring significantly fewer physical qubits per logical qubit and providing a more efficient pathway to fault-tolerant quantum computing. By focusing on solid-state quantum bits, the company enables clients to perform error-free computations, thereby accelerating research and advancing the practical applications of quantum technology.
Quintessent is a Santa Barbara start-up that commercializes quantum dot-based lasers and photonic integrated circuits. Its solutions leverage the unique properties of quantum dot gain media with co-designed architectures to enable future applications in optical networking, deep learning systems, and sensing. It is based in Santa Barbara, California.
Nocion Therapeutics is a developer of novel pharmaceuticals intended to treat the conditions arising from neurogenic inflammation. The company is developing "nocions" which are a new kind of therapy that selectively affects actively firing nociceptors, enabling patients to provide targeted, robust and sustained relief for the treatment of serious conditions including cough, itch, pain and inflammation.
AssetWatch specializes in proactive and predictive maintenance solutions aimed at preventing unplanned downtime for global manufacturers. The company offers an extensive remote condition monitoring service that integrates wireless sensors and communication hubs with sophisticated software. These wireless vibration and temperature sensors gather critical machine health data, which is analyzed using machine learning algorithms and the expertise of condition monitoring engineers. This analysis provides actionable insights that go beyond simple pass/fail assessments, enabling manufacturers to transition from a reactive to a proactive maintenance culture. By delivering prescriptive recommendations, AssetWatch supports manufacturers in optimizing their maintenance processes and enhancing operational reliability.
BioAge Labs, Inc. is a biotechnology company focused on developing therapies to address aging and age-related diseases. The company utilizes a systems biology and artificial intelligence platform to identify key drug targets that influence aging and analyze extensive datasets to uncover the molecular drivers of age-related conditions. BioAge Labs is advancing several drug candidates, including BGE-117, a hypoxia-inducible factor prolyl hydroxylase inhibitor designed to activate genes involved in critical biological processes such as tissue regeneration and vascular remodeling. Additionally, BGE-175, an orally administered inhibitor of the prostaglandin D2 DP1 signaling pathway, aims to mitigate risks associated with immune aging and respiratory infections. Founded in 2015 and based in Richmond, California, BioAge Labs is committed to discovering and developing innovative treatments that harness the biology of human aging.
Verve Motion specializes in the development of exo-suits aimed at assisting workers engaged in physically demanding tasks. The company utilizes a combination of robotics, apparel design, and movement science to create lightweight wearables crafted from textile materials. These exo-suits are designed to adapt to the movements of the wearer, providing necessary support and force during critical moments while remaining nonrestrictive at other times. By focusing on safety and comfort, Verve Motion enhances the capabilities of workers in various industries, promoting a more efficient and secure working environment.
Precede Biosciences is breaking down the barriers to precision medicine by redefining what can be gleaned from a simple blood draw. Precede aims to increase drug development success rates and to contribute to a future in which every patient can receive a speedy, minimally invasive diagnosis and therapy tailored to the biology of their condition.
ReCode Therapeutics is a biopharmaceutical company focused on developing precision medicines for pulmonary diseases, particularly targeting genetic conditions such as primary ciliary dyskinesia and cystic fibrosis. Founded in 2015 and based in Menlo Park, California, the company employs a unique non-viral lipid nanoparticle platform that facilitates the precise delivery of nucleic acid and protein payloads to specific organs and tissues, enhancing the effectiveness of genetic therapies. This selective organ targeting (SORT) technology allows for the administration of corrective or disease-modifying treatments beyond the liver, addressing the challenges faced by traditional gene therapy methods. By harnessing these innovative techniques, ReCode Therapeutics aims to provide new therapeutic options for patients suffering from rare and life-limiting respiratory diseases.
Kate Therapeutics is a biotechnology company dedicated to developing adeno-associated virus (AAV)-based gene therapies for genetically defined muscle and heart diseases. The company employs advanced technology platforms to enhance tissue-specific delivery and gene regulation, overcoming significant challenges associated with current gene therapies. By utilizing innovative capsids, Kate Therapeutics achieves superior muscle transduction and effectively de-targets the liver, allowing for more efficient tissue transduction at lower viral doses. This approach addresses key limitations in muscle gene delivery, aiming to improve treatment outcomes for patients with muscle and heart conditions.
Chroma Medicine is a genomic medicine company based in Cambridge, Massachusetts, founded in 2021. The company focuses on epigenetic editing, aiming to revolutionize the treatment of genetically driven diseases. By utilizing epigenetics, which is nature's inherent mechanism for regulating genes, Chroma Medicine develops programmable epigenetic editors that target specific genes and control chromatin conformation. This innovative approach combines a DNA binding domain with epigenetic effector domains, providing medical practitioners with a new class of therapeutics that offers enhanced control over gene expression.
Hack The Box Ltd. is an online platform founded in 2017, based in Folkestone, United Kingdom, that focuses on enhancing skills in penetration testing and cybersecurity for individuals, organizations, and educational institutions. The platform offers a variety of guided and exploratory learning experiences, allowing users to improve both offensive and defensive security skills. Through challenges that simulate real-world scenarios and capture-the-flag style tasks, Hack The Box enables users to learn new techniques and refine their hacking abilities, thereby preparing them for various cybersecurity challenges. This makes it a valuable resource for professionals seeking to advance their expertise in the rapidly evolving field of cybersecurity.
Opsys Technology Co., Ltd. specializes in designing and developing optical communication products, focusing on solutions that utilize advanced fiber optics technologies. The company's product offerings include LIDAR systems, RF over fiber links for various applications such as remote antenna and distributed antenna systems, as well as mixed signal solutions for aircraft and maritime environments. Opsys Tech is also active in sectors requiring temperature and strain sensors, as well as data center switching technologies. With a strong emphasis on autonomous vehicle control and intelligent sensors, the company is committed to innovating new applications within the optical market. Founded as a spinoff from a leading optical communication firm, Opsys Tech is based in Holon, Israel, and continues to expand its portfolio to meet the demands of modern technological advancements.
Escient Pharmaceuticals is a biotechnology company based in San Diego, California, that develops and manufactures drugs targeting G protein-coupled receptors (GPCRs) for the treatment of neuro-immuno-inflammatory and autoreactive diseases. Founded in 2017, the company specializes in harnessing the therapeutic potential of specific orphan GPCRs, particularly the Mas-Related G-Protein Receptors (Mrgprs), to address various neurosensory-inflammatory disorders. Escient's innovative approach aims to provide first-in-class therapies for conditions associated with mast cell-mediated disorders and cholestatic pruritus, thereby expanding treatment options for healthcare providers and patients facing these challenging diseases.
Normunity is a biotechnology company focused on developing precision immuno-oncology medicines, specifically a new class known as immune normalizers. These medicines aim to target novel mechanisms that enhance the body’s natural immune response against cancer. In collaboration with the lab of Dr. Lieping Chen at Yale School of Medicine, Normunity is researching newly-discovered mechanisms of immune disruption in cancer, utilizing proprietary discovery platforms to explore the intricate interactions between cancer and the immune system. The company is advancing a pipeline of immune normalizers, which includes initial drug programs designed to address the exclusion of T-cells from immune-sensitive tumors and other factors that impede normal immune function in cancer. Normunity operates from locations in Boston, Massachusetts, and West Haven, Connecticut.
Metalenz, Inc. is a company focused on the research, development, and production of advanced optical components, particularly for consumer electronics such as mobile phones and computers. Established in 2016 and headquartered in Weston, Massachusetts, with an additional office in San Francisco, Metalenz specializes in meta-optics that utilize structured Huygens' surfaces to manipulate light properties. This innovative approach allows for the creation of ultra-thin planar optics that enable high-resolution full-color imaging. By offering smaller and lighter alternatives to traditional lenses, Metalenz supports businesses in miniaturizing their products, enhancing their design flexibility and functionality in various high-volume applications, including automotive and other electronic devices.
Delfi Diagnostics, Inc. is a biotechnology company based in Baltimore, Maryland, focused on the early detection of cancer through innovative blood tests. Founded in 2019, the company utilizes artificial intelligence and genome sequencing to identify unique patterns of DNA fragmentation in patients' blood. By employing machine learning techniques, Delfi Diagnostics develops high-precision, non-invasive tests that aim to detect cancer at a stage when it is most treatable. Their technology enables healthcare professionals to recognize previously unrecognized cancer-associated cell-free DNA fragments, facilitating timely and effective treatment options for patients.
AssetWatch specializes in proactive and predictive maintenance solutions aimed at preventing unplanned downtime for global manufacturers. The company offers an extensive remote condition monitoring service that integrates wireless sensors and communication hubs with sophisticated software. These wireless vibration and temperature sensors gather critical machine health data, which is analyzed using machine learning algorithms and the expertise of condition monitoring engineers. This analysis provides actionable insights that go beyond simple pass/fail assessments, enabling manufacturers to transition from a reactive to a proactive maintenance culture. By delivering prescriptive recommendations, AssetWatch supports manufacturers in optimizing their maintenance processes and enhancing operational reliability.
MicroTransponder, Inc. is a medical device company based in Austin, Texas, specializing in the development and commercialization of neurostimulation devices aimed at treating neurological disorders. Founded in 2007, the company focuses on therapies that utilize vagus nerve stimulation to address conditions such as tinnitus, chronic pain, and rehabilitation following strokes. Its flagship product, Vivistim, has received FDA approval for use in ischemic stroke survivors experiencing moderate to severe upper limb impairment. MicroTransponder's innovative approaches, which include paired vagus nerve stimulation and wireless neurostimulation systems, are designed to enhance recovery and improve quality of life for patients facing various neurological challenges.
Brimstone is a company that has developed a carbon-negative process for producing ordinary Portland cement and supplementary cementitious material. Founded in 2019 and based in Oakland, California, Brimstone's innovative technology employs carbon-free calcium silicate rock instead of traditional limestone, resulting in a product that matches the performance of conventional materials while remaining cost-competitive at scale. This advancement aims to provide the construction industry with a cleaner and more sustainable alternative to traditional cement production methods.
Antiva Biosciences is a biopharmaceutical company based in South San Francisco, California, focused on developing antiviral drugs to treat human papillomavirus (HPV) infections. Founded in 2012 and previously known as Hera Therapeutics, the company aims to prevent cancer by addressing precancerous lesions associated with HPV. Antiva's innovative approach involves localized therapeutics and small molecule antivirals designed to improve health outcomes for patients suffering from diseases linked to HPV and other viruses. The company's clinical programs target high-grade anal intraepithelial neoplasias and high-grade cervical intraepithelial neoplasias, utilizing a medicinal chemistry platform that emphasizes the development and commercialization of direct-acting antivirals.
ReCode Therapeutics is a biopharmaceutical company focused on developing precision medicines for pulmonary diseases, particularly targeting genetic conditions such as primary ciliary dyskinesia and cystic fibrosis. Founded in 2015 and based in Menlo Park, California, the company employs a unique non-viral lipid nanoparticle platform that facilitates the precise delivery of nucleic acid and protein payloads to specific organs and tissues, enhancing the effectiveness of genetic therapies. This selective organ targeting (SORT) technology allows for the administration of corrective or disease-modifying treatments beyond the liver, addressing the challenges faced by traditional gene therapy methods. By harnessing these innovative techniques, ReCode Therapeutics aims to provide new therapeutic options for patients suffering from rare and life-limiting respiratory diseases.
Vanqua Bio is a biotechnology company dedicated to discovering and developing innovative medicines for patients suffering from neurodegenerative diseases. The company leverages a technology platform that incorporates human genetics and patient-derived neuronal cells to identify and validate new disease pathways linked to lysosomal dysfunction and the inappropriate activation of the innate immune system. Vanqua Bio focuses on creating small-molecule activators of glucocerebrosidase and advancing programs that target the innate immune system, with the aim of addressing the progression of various neurological disorders. Through its efforts, the company seeks to provide healthcare professionals with transformative treatment options for patients facing these challenging conditions.
Corelight, Inc. provides network visibility solutions tailored for information security professionals, focusing on network traffic analysis to combat cyber threats. The company offers a suite of products, including Corelight sensors and a fleet manager, built upon the open-source Bro framework, which delivers actionable, real-time data to enhance cybersecurity efforts. Founded in 2013 and headquartered in San Francisco, California, Corelight serves enterprises, government agencies, and higher education institutions, enabling them to gain deep insights into network traffic and effectively detect and respond to cyberattacks. The company also maintains additional offices in Santa Clara, California, and Columbus, Ohio.
eFFECTOR Therapeutics Inc is a clinical-stage biopharmaceutical company based in San Diego, California. Established in 2012, the company specializes in developing selective translation regulators for cancer and other serious diseases. Its innovative approach involves small molecule drugs known as selective translation regulator inhibitors (STRIs), which target the eIF4F complex and its associated kinase, mitogen-activated protein kinase 1/2 (MNK 1/2). This complex plays a crucial role in the translation of specific messenger RNA into proteins linked to cancer progression. eFFECTOR's lead product candidate, tomivosertib, is currently being evaluated in a Phase 2b trial in combination with pembrolizumab for non-small cell lung cancer. Additionally, zotatifin, an inhibitor of eIF4A, is undergoing dose-escalation trials with plans for further expansion. The company also collaborates with Pfizer to develop inhibitors targeting eIF4E. Through these efforts, eFFECTOR aims to address the challenges of tumor growth, survival, and immune evasion in cancer treatment.
DICE Therapeutics is a biopharmaceutical company that utilizes its proprietary technology platform to develop a pipeline of novel oral therapeutic candidates aimed at treating chronic diseases, particularly in the field of immunology. The company focuses on creating oral therapeutics that target well-established proteins, intending to achieve efficacy similar to existing systemic biologics. DICE's DELSCAPE platform is specifically designed to discover selective oral small molecules capable of modulating protein-protein interactions effectively. Its lead candidate, S011806, is an oral antagonist targeting interleukin-17, a key player in various immunological conditions. In addition to S011806, DICE is developing other oral therapeutic candidates that target α4ß7 integrin and αVß1/αVß6 integrin, aimed at treating inflammatory bowel disease and idiopathic pulmonary fibrosis, respectively.
Sonoma Biotherapeutics is a company invloved the development of adoptive Treg therapies cell for autoimmune and degenerative diseases. Using next generation genome editing and target-specific cell therapy, Sonoma is focused on developing its best-in-class platform across the entire spectrum of Treg cell therapeutic capabilities. Founded by pioneers in Treg biology and cell therapy, the company brings together leading expertise and proprietary methodologies for the discovery and development of disease modifying and curative therapies.
Verve Motion specializes in the development of exo-suits aimed at assisting workers engaged in physically demanding tasks. The company utilizes a combination of robotics, apparel design, and movement science to create lightweight wearables crafted from textile materials. These exo-suits are designed to adapt to the movements of the wearer, providing necessary support and force during critical moments while remaining nonrestrictive at other times. By focusing on safety and comfort, Verve Motion enhances the capabilities of workers in various industries, promoting a more efficient and secure working environment.
Glyphic Biotechnologies is a biotechnology company focused on developing an advanced protein sequencing platform that aims to enhance understanding of biological functions and diseases. Unlike DNA sequencing, which offers limited insights, this next-generation platform provides deeper knowledge through single-molecule, massively parallel sequencing. By improving binding affinity and consistency, Glyphic's technology supports the creation of personalized and precision cancer vaccines tailored to individual patients. The company's innovative approach enables scientists and researchers to develop novel therapeutics and diagnostics, ultimately advancing the comprehension of human biology and disease mechanisms.
Ribon Therapeutics, Inc. is a biotechnology company based in Lexington, Massachusetts, focused on developing novel cancer therapies that target monoPARP proteins, which are essential regulators of cancer survival mechanisms. Established in 2015, Ribon is leveraging insights from its scientific founders and an experienced management team to create a proprietary drug discovery platform aimed at understanding the molecular actions and biological functions of monoPARPs. This platform enables the development of small molecule inhibitors designed to disrupt cancer cells' abilities to withstand stress, potentially leading to innovative treatments for cancer and other diseases. The company is supported by notable life science investors, positioning it for growth in the biopharmaceutical sector.
Interius BioTherapeutics is a biopharmaceutical company that develops in vivo cell-specific gene medicines to treat B cell lymphomas. Intravenous in vivo CAR treatment, which treats B cell lymphomas, is the company's flagship program. Its unique engineering provides exceptional target tissue specificity. The business is working on a second initiative to address autoimmune conditions. With the help of Interius, a novel and distinct therapeutic modality for the precise administration of gene therapies may soon be made available to patients in expanded care settings, without the need for preconditioning chemotherapy.
Hack The Box Ltd. is an online platform founded in 2017, based in Folkestone, United Kingdom, that focuses on enhancing skills in penetration testing and cybersecurity for individuals, organizations, and educational institutions. The platform offers a variety of guided and exploratory learning experiences, allowing users to improve both offensive and defensive security skills. Through challenges that simulate real-world scenarios and capture-the-flag style tasks, Hack The Box enables users to learn new techniques and refine their hacking abilities, thereby preparing them for various cybersecurity challenges. This makes it a valuable resource for professionals seeking to advance their expertise in the rapidly evolving field of cybersecurity.
Fortis Therapeutics is a biotechnology company specializing in immuno-oncology, dedicated to developing innovative antibody-drug conjugate therapies targeting CD46. The company focuses on treating late-stage multiple myeloma and prostate cancer, among other indications. Its platform is designed to advance therapies for both adenocarcinoma and neuroendocrine cancers, providing healthcare professionals with effective treatment options for patients facing these advanced stages of cancer.
Artizan Biosciences, Inc. is a biotechnology company based in New Haven, Connecticut, founded in 2016. The company focuses on developing small molecule drugs aimed at treating serious diseases linked to intestinal inflammation. Utilizing its proprietary IgA-SEQ technology platform, Artizan distinguishes disease-driving bacteria within the intestinal microbiota. This innovative approach enables the development of precision therapeutics designed to address unmet medical needs in various conditions, including digestive disorders, obesity, autoimmune diseases, and disorders affecting the skin, lungs, and central nervous system. Through its research, Artizan aims to provide new and potentially curative treatment options for patients suffering from these diverse health challenges.
Cyteir Therapeutics, Inc. is a clinical-stage biotechnology company based in Lexington, Massachusetts, focused on developing innovative therapies that leverage the biology of DNA repair for cancer treatment and synthetic lethality in autoimmune diseases. The company utilizes its expertise in DNA damage response biology to create a pipeline of small molecule therapeutics aimed at selectively targeting vulnerabilities in cancer cells and inducing their self-destruction through DNA damage overload. Cyteir's lead compound, CYT-0851, is an oral investigational drug designed to inhibit RAD51-mediated homologous recombination, which is crucial for repairing double-strand DNA breaks. The company is dedicated to addressing a variety of hematological malignancies, solid tumors, and chronic autoimmune disorders through its integrated drug development platform. Founded in 2012, Cyteir is committed to advancing next-generation therapies that can improve patient outcomes in challenging disease states.
Delfi Diagnostics, Inc. is a biotechnology company based in Baltimore, Maryland, focused on the early detection of cancer through innovative blood tests. Founded in 2019, the company utilizes artificial intelligence and genome sequencing to identify unique patterns of DNA fragmentation in patients' blood. By employing machine learning techniques, Delfi Diagnostics develops high-precision, non-invasive tests that aim to detect cancer at a stage when it is most treatable. Their technology enables healthcare professionals to recognize previously unrecognized cancer-associated cell-free DNA fragments, facilitating timely and effective treatment options for patients.
DICE Therapeutics is a biopharmaceutical company that utilizes its proprietary technology platform to develop a pipeline of novel oral therapeutic candidates aimed at treating chronic diseases, particularly in the field of immunology. The company focuses on creating oral therapeutics that target well-established proteins, intending to achieve efficacy similar to existing systemic biologics. DICE's DELSCAPE platform is specifically designed to discover selective oral small molecules capable of modulating protein-protein interactions effectively. Its lead candidate, S011806, is an oral antagonist targeting interleukin-17, a key player in various immunological conditions. In addition to S011806, DICE is developing other oral therapeutic candidates that target α4ß7 integrin and αVß1/αVß6 integrin, aimed at treating inflammatory bowel disease and idiopathic pulmonary fibrosis, respectively.
Neuros Medical, Inc. is a neuromodulation company based in Willoughby Hills, Ohio, that specializes in developing proprietary neurostimulation therapies aimed at addressing unmet medical needs for patients globally. The company's flagship technology, known as Electrical Nerve Block, targets chronic pain conditions, including neuroma and residual limb pain, chronic post-surgical pain, and chronic migraine. Neuros Medical also offers the Neuros Altius System, which features an implantable generator with an integrated rechargeable battery, a cuff electrode, and associated external devices. Established in 2008, the company is dedicated to advancing innovative solutions for pain management.
Coho Therapeutics, Inc. is a biotechnology company based in San Diego, California, founded in 2019 by Bruce Clurman and Jayson Punwani. The company specializes in developing molecular glue therapeutics aimed at protein degradation, which is a novel approach to treating conditions such as cancer, neurodegeneration, and other serious diseases. By leveraging this innovative technology, Coho Therapeutics seeks to create medicines that can effectively prevent and combat various life-threatening illnesses, contributing to advancements in healthcare.
Atsena Therapeutics is a clinical-stage gene therapy company focused on developing treatments for inherited retinal diseases that can lead to blindness. Their clinical pipeline includes therapies for conditions such as X-linked retinoschisis and GUCY2D-associated Leber congenital amaurosis. Atsena employs an adeno-associated virus (AAV) technology platform, including a novel spreading capsid, to specifically target these retinal disorders. The company aims to prevent vision loss caused by genetic mutations through innovative ocular gene therapy solutions. With a commitment to advancing treatments for some of the most challenging forms of inherited retinal disease, Atsena Therapeutics seeks to improve the lives of patients affected by these conditions.
Menlo Security provides a cloud-based isolation platform that protects organizations from cyberattacks by eliminating the threat of malware from websites, documents, and emails. Menlo Security is trusted by major global businesses, including Fortune 500 companies and financial services institutions, and backed by Vista Equity Partners, Neuberger Berman, General Catalyst, Sutter Hill Ventures, Engineering Capital, Osage University Partners, American Express Ventures, Ericsson Ventures, HSBC, and JP Morgan Chase. Menlo Security was founded in 2012 and headquartered in Mountain View, California.
Palladio Bio is a clinical-stage company developing transformative medicines for orphan diseases of the kidney. The company specializes in the fields of biotechnology, pharmaceutical. and therapeutics. Its products are designed for renal disease, kidney disease, and polycystic kidney disease. The company was founded in 2015 and headquartered in Horsham, Pennsylvania.
Escient Pharmaceuticals is a biotechnology company based in San Diego, California, that develops and manufactures drugs targeting G protein-coupled receptors (GPCRs) for the treatment of neuro-immuno-inflammatory and autoreactive diseases. Founded in 2017, the company specializes in harnessing the therapeutic potential of specific orphan GPCRs, particularly the Mas-Related G-Protein Receptors (Mrgprs), to address various neurosensory-inflammatory disorders. Escient's innovative approach aims to provide first-in-class therapies for conditions associated with mast cell-mediated disorders and cholestatic pruritus, thereby expanding treatment options for healthcare providers and patients facing these challenging diseases.
ESCAPE Bio is a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapies for genetically defined subpopulations affected by neurodegenerative diseases. Founded in 2015 and based in South San Francisco, California, the company aims to improve the lives of patients suffering from conditions such as Alzheimer's disease, Parkinson's disease, and sphingolipid storage disorders. ESCAPE Bio's pipeline includes innovative candidates like ESB1609, a small molecule S1P5 receptor agonist targeting CNS lysosomal storage disorders, and ESB5070, a kinase inhibitor specifically designed for Parkinson's patients with the LRRK2 G2019S variant. Additionally, the company is developing a program aimed at addressing the needs of Alzheimer's patients who carry the ApoE4 risk allele. Through its precision-targeted approach, ESCAPE Bio seeks to provide effective treatment options for individuals with these complex genetic profiles.
Nido Biosciences, Inc., founded in 2018 and based in Boston, Massachusetts, is a clinical-stage company focused on developing precision medicines for severe neurological diseases. The company utilizes a functional genomics discovery platform based on human cell lines to identify novel therapeutic targets, addressing the underlying biology of neurodegenerative diseases. By leveraging advancements in neuroscience and human genetics, Nido aims to create precise medications that restore healthy cell function and improve treatment options for conditions that significantly impact patient quality of life.
SiFive, Inc. specializes in designing and manufacturing semiconductors, focusing on RISC-V architecture. The company offers a range of products including multi-core application processors, embedded microcontrollers, and customized silicon solutions. Its platform enables the development of chips for various applications, such as microcontrollers, the Internet of Things (IoT), and wearables, emphasizing the integration of open-source principles and software automation to streamline hardware development. SiFive aims to democratize access to custom silicon, allowing system designers to innovate more rapidly and cost-effectively. Founded in 2015 and headquartered in San Mateo, California, SiFive also has development offices and locations in several regions including Oregon, Texas, India, Taiwan, and France. The company has established a strategic partnership with QuickLogic Corporation to further enhance its offerings in the semiconductor industry.
Aerovate Therapeutics is a clinical-stage biotechnology company based in Boston, Massachusetts, dedicated to developing innovative treatments for patients with rare cardiopulmonary diseases. The company's primary focus is on AV-101, a proprietary inhaled dry powder formulation of the drug imatinib, designed specifically for the treatment of pulmonary arterial hypertension (PAH). This formulation enables targeted delivery of the medication directly to affected lung tissues, thereby minimizing systemic side effects commonly associated with traditional treatments. Established in 2018, Aerovate aims to provide meaningful improvements in the lives of those suffering from these serious conditions.
Censys, Inc. specializes in internet scanning and asset identification solutions, offering a platform that enables organizations to gain a real-time view of global networks and devices. Founded in 2017 and based in Ann Arbor, Michigan, Censys provides tools for attack surface management, allowing users to discover unknown assets, monitor remote workforces, and identify threat actors. Its internet intelligence platform is designed for threat hunting and exposure management, creating a comprehensive dataset that enhances visibility into vulnerabilities and internet-exposed infrastructure. This enables businesses to efficiently locate and manage the devices, networks, and infrastructure that are critical to their operations.
Vor Biopharma, Inc. is a clinical-stage biotechnology company based in Cambridge, Massachusetts, focused on developing engineered hematopoietic stem cell (eHSC) therapies for cancer treatment. The company's lead product candidate, VOR33, is designed specifically for the treatment of acute myeloid leukemia (AML) and is currently in preclinical development. VOR33 eHSCs are engineered to lack CD33, a protein commonly expressed by AML cells, allowing for selective targeting of the cancer without harming normal cells. This innovative approach seeks to minimize the toxicities associated with traditional immunotherapies, which often affect both cancerous and healthy tissues. By protecting healthy stem cells from depletion while generating functional immune cells, Vor Biopharma aims to enhance therapeutic outcomes for patients with hematological malignancies.
StreetLight Data brings mobility patterns to light for planners, modelers, and engineers by giving them on-demand access to the Big Data resources and processing software for transportation. Their online platform, StreetLight InSight lets its users turn anonymous location data from millions of mobile devices into customized, actionable analytics. It was founded in 2012 and is headquartered in San Francisco, California.
Atsena Therapeutics is a clinical-stage gene therapy company focused on developing treatments for inherited retinal diseases that can lead to blindness. Their clinical pipeline includes therapies for conditions such as X-linked retinoschisis and GUCY2D-associated Leber congenital amaurosis. Atsena employs an adeno-associated virus (AAV) technology platform, including a novel spreading capsid, to specifically target these retinal disorders. The company aims to prevent vision loss caused by genetic mutations through innovative ocular gene therapy solutions. With a commitment to advancing treatments for some of the most challenging forms of inherited retinal disease, Atsena Therapeutics seeks to improve the lives of patients affected by these conditions.
ReCode Therapeutics is a biopharmaceutical company focused on developing precision medicines for pulmonary diseases, particularly targeting genetic conditions such as primary ciliary dyskinesia and cystic fibrosis. Founded in 2015 and based in Menlo Park, California, the company employs a unique non-viral lipid nanoparticle platform that facilitates the precise delivery of nucleic acid and protein payloads to specific organs and tissues, enhancing the effectiveness of genetic therapies. This selective organ targeting (SORT) technology allows for the administration of corrective or disease-modifying treatments beyond the liver, addressing the challenges faced by traditional gene therapy methods. By harnessing these innovative techniques, ReCode Therapeutics aims to provide new therapeutic options for patients suffering from rare and life-limiting respiratory diseases.
PMV Pharmaceuticals, Inc. is a precision oncology company focused on discovering and developing small molecule therapies targeting p53 mutations in cancer. The company's lead candidate, PC14586, aims to correct and restore the function of p53, a critical tumor suppressor protein. In addition to this product, PMV Pharmaceuticals is also working on therapies for specific p53 hotspot mutations, including the R273H mutation. Founded in 2013 and headquartered in Cranbury, New Jersey, the company leverages over three decades of expertise in p53 biology, aiming to develop first-in-class modulators that could improve treatment outcomes for cancer patients.
IonQ, Inc. specializes in the development of general-purpose quantum information computers, utilizing a trapped ion approach that allows for qubit replication and optimized algorithms. Founded in 2015 and headquartered in College Park, Maryland, the company aims to overcome the limitations of classical computing by harnessing the principles of superposition and entanglement at the atomic scale. IonQ offers access to its quantum computers with varying qubit capacities, primarily through cloud platforms, making quantum computing available as a service. In addition to its cloud offerings, the company generates revenue from consulting services that involve co-developing algorithms tailored for its quantum systems. IonQ is actively engaged in research and development to enhance the computational capabilities of its quantum technologies.
ArsenalBio is a programmable cell therapy company established in 2019, focused on developing effective and accessible immune cell therapies, primarily targeting cancer treatment. The company utilizes advanced technologies, including CRISPR-based genome engineering, synthetic biology, and machine learning, to create a new paradigm for discovering and developing immune cell therapies. ArsenalBio's innovative approach aims to enhance the efficacy and safety of T-cell therapies while reducing costs for providers and broadening patient access. By employing a full-stack research and development engine, ArsenalBio generates multifunctional T-cell medicines through the precise insertion of large synthetic DNA sequences, enabling clinicians to utilize next-generation autologous T-cell therapies to combat cancer more effectively.
Cyteir Therapeutics, Inc. is a clinical-stage biotechnology company based in Lexington, Massachusetts, focused on developing innovative therapies that leverage the biology of DNA repair for cancer treatment and synthetic lethality in autoimmune diseases. The company utilizes its expertise in DNA damage response biology to create a pipeline of small molecule therapeutics aimed at selectively targeting vulnerabilities in cancer cells and inducing their self-destruction through DNA damage overload. Cyteir's lead compound, CYT-0851, is an oral investigational drug designed to inhibit RAD51-mediated homologous recombination, which is crucial for repairing double-strand DNA breaks. The company is dedicated to addressing a variety of hematological malignancies, solid tumors, and chronic autoimmune disorders through its integrated drug development platform. Founded in 2012, Cyteir is committed to advancing next-generation therapies that can improve patient outcomes in challenging disease states.
Landos Biopharma is a developer of an oral first-in-class therapeutics designed to target autoimmune diseases.The company's therapeutics are novel, locally-acting small molecules targeting inflammatory bowel disease (IBD), crohn's disease (CD) and ulcerative colitis (UC), enabling healthcare providers to cure their patients.
Cleave Therapeutics develops oncology pharmaceuticals designed to target neurodengeneration and pathways used by cancer cells to grow. The company is engaged in the discovery of novel, small-molecule drugs that affect protein-degradation pathways, upon which cancer cells depend for survival, enabling patients to get cured from cancer.
Menlo Security provides a cloud-based isolation platform that protects organizations from cyberattacks by eliminating the threat of malware from websites, documents, and emails. Menlo Security is trusted by major global businesses, including Fortune 500 companies and financial services institutions, and backed by Vista Equity Partners, Neuberger Berman, General Catalyst, Sutter Hill Ventures, Engineering Capital, Osage University Partners, American Express Ventures, Ericsson Ventures, HSBC, and JP Morgan Chase. Menlo Security was founded in 2012 and headquartered in Mountain View, California.
Artizan Biosciences, Inc. is a biotechnology company based in New Haven, Connecticut, founded in 2016. The company focuses on developing small molecule drugs aimed at treating serious diseases linked to intestinal inflammation. Utilizing its proprietary IgA-SEQ technology platform, Artizan distinguishes disease-driving bacteria within the intestinal microbiota. This innovative approach enables the development of precision therapeutics designed to address unmet medical needs in various conditions, including digestive disorders, obesity, autoimmune diseases, and disorders affecting the skin, lungs, and central nervous system. Through its research, Artizan aims to provide new and potentially curative treatment options for patients suffering from these diverse health challenges.
SiFive, Inc. specializes in designing and manufacturing semiconductors, focusing on RISC-V architecture. The company offers a range of products including multi-core application processors, embedded microcontrollers, and customized silicon solutions. Its platform enables the development of chips for various applications, such as microcontrollers, the Internet of Things (IoT), and wearables, emphasizing the integration of open-source principles and software automation to streamline hardware development. SiFive aims to democratize access to custom silicon, allowing system designers to innovate more rapidly and cost-effectively. Founded in 2015 and headquartered in San Mateo, California, SiFive also has development offices and locations in several regions including Oregon, Texas, India, Taiwan, and France. The company has established a strategic partnership with QuickLogic Corporation to further enhance its offerings in the semiconductor industry.
Algorithmia, Inc. provides a platform that facilitates the deployment and management of machine learning models. Founded in 2013 and headquartered in Seattle, Washington, the company enables algorithm developers to create, explore, and share algorithms as web services. Its solution automates MLOps, allowing data scientists and developers to efficiently deploy models into production through a scalable API that can handle various algorithm requests. Algorithmia supports popular frameworks such as TensorFlow, PyTorch, Scikit-learn, and MXNet, and also hosts a public marketplace for algorithms. The company was acquired by DataRobot in 2021, enhancing its capabilities in serving enterprise customers with mission-critical workloads.
Twentyeight-Seven Therapeutics is a developer of microRNAs designed to target regulatory proteins.The company's modulating RNA which are short non-coding RNAs that inhibit target gene expression by suppressing mRNA translation and promoting mRNA decay and develop small molecules that can modulate levels of miRNAs by targeting proteins that interact with these miRNAs, enabling users to target miRNAs are directly involved in cancer initiation, progression, and metastasis.
LunaPBC, Inc. is a Public Benefit Corporation based in San Diego, California, that develops a community-owned platform for genomic and medical research. The company's primary offering, LunaDNA, serves as a knowledge database where individuals can share their health and DNA data to contribute to health research and drive medical discoveries. This platform is designed to benefit both non-profit and for-profit health research projects, facilitating collaboration among pharmaceutical, insurance, and healthcare IT companies. In addition to advancing medical research, LunaPBC allows its members to share in the financial benefits derived from medical breakthroughs, promoting a model of shared community ownership.
Created by co-founders of the $40B DNA sequencing leader Illumina, Luna DNA incentivizes the sharing of health and DNA data for research. LunaDNA rewards people for sharing the data they already own while contributing to medical research and discovery that saves lives. DNA sequencing data has become siloed. As personal DNA sequencing has risen in popularity, the data has become siloed as each company looks to maximize their individual profit from this data. There is currently little incentive for consumers to contribute their DNA and health information to a third party database. There are also multiple privacy, security, and trust issues that limit broad participation. The solution is LunaDNA. LunaDNA is a community owned database that rewards individuals shares in the database and rewards for contributing their health and DNA data. Shares entitle members to a share in the profits from medical research and discoveries. The proceeds flow back to the community like dividends as researchers pay to access the data for discovery.
Satsuma Pharmaceuticals is a clinical-stage biopharmaceutical company focused on developing innovative treatments for migraine. The company's lead product candidate, STS101, is a drug-device combination that features a proprietary dry-powder formulation of dihydroergotamine mesylate. This product is designed for self-administration through a pre-filled, single-use nasal delivery device and is currently undergoing Phase III clinical trials. Founded in 2016 and based in South San Francisco, California, Satsuma aims to provide an effective therapeutic option for individuals suffering from acute migraine episodes.
Arrakis Therapeutics, Inc. is a biopharmaceutical company focused on developing a proprietary platform for drug discovery that targets ribonucleic acid (RNA). The company aims to identify new RNA targets and create small-molecule drug candidates, primarily addressing cancer and other genetically validated diseases. Its innovative platform combines advanced RNA bioinformatics, structural tools, chemical biology, and medicinal chemistry, facilitating the development of RNA-targeted small molecules (rSMs). Additionally, Arrakis offers SHAPEware, a software tool designed to predict RNA secondary structures and potential ligand-binding sites. Founded in 2015, Arrakis Therapeutics is headquartered in Waltham, Massachusetts, and its work enables improved treatment options for various conditions, including neurological disorders and rare genetic diseases.
Hyalex Orthopaedics is a Lexington, MA medical device company advancing new products that feature HYALEX™ materials technology, a polymer that is designed to mimic cartilage. Unlike other polymers, synthetic HYALEX material has the unique capability of maintaining low friction and low wear under the high loads encountered in human joints. Hyalex Orthopaedics' products are in the development stage and have not been approved for use in humans by any regulatory agency.
Vor Biopharma, Inc. is a clinical-stage biotechnology company based in Cambridge, Massachusetts, focused on developing engineered hematopoietic stem cell (eHSC) therapies for cancer treatment. The company's lead product candidate, VOR33, is designed specifically for the treatment of acute myeloid leukemia (AML) and is currently in preclinical development. VOR33 eHSCs are engineered to lack CD33, a protein commonly expressed by AML cells, allowing for selective targeting of the cancer without harming normal cells. This innovative approach seeks to minimize the toxicities associated with traditional immunotherapies, which often affect both cancerous and healthy tissues. By protecting healthy stem cells from depletion while generating functional immune cells, Vor Biopharma aims to enhance therapeutic outcomes for patients with hematological malignancies.
KenSci Inc. is a healthcare technology company that has developed a machine learning platform aimed at improving risk management for healthcare providers and payers. Founded in 2015 and headquartered in Seattle, Washington, with additional offices in Hyderabad, India, and Singapore, KenSci's platform enables early intervention by predicting clinical, financial, and operational risks. It integrates healthcare data from various sources, including electronic medical records and claims data, to identify patterns and high-risk markers. The platform features a library of pre-built models and modular solutions that can be incorporated into existing workflows, enhancing hospital operations by reducing costs and improving care coordination. Additionally, KenSci employs Explainable AI models to ensure that its risk predictions are both efficient and accountable. The company also has a strategic partnership with T3k Health, further expanding its impact in the healthcare sector.
Seismos is a data analytics company focused on production optimization through its innovative K-wave technology, which enables real-time monitoring of underground fluid flow during production. Unlike traditional seismic methods, which are time-consuming and costly, Seismos offers a non-invasive, cloud-based solution that provides immediate insights at a significantly lower cost. The company's AI-powered sensing systems utilize advanced acoustic sensing and machine learning to detect and predict anomalies across various sectors, including upstream oil and gas, pipelines, and geothermal markets. By delivering real-time data, Seismos empowers organizations to make informed decisions and enhance operational efficiency without disrupting production processes.
Ribon Therapeutics, Inc. is a biotechnology company based in Lexington, Massachusetts, focused on developing novel cancer therapies that target monoPARP proteins, which are essential regulators of cancer survival mechanisms. Established in 2015, Ribon is leveraging insights from its scientific founders and an experienced management team to create a proprietary drug discovery platform aimed at understanding the molecular actions and biological functions of monoPARPs. This platform enables the development of small molecule inhibitors designed to disrupt cancer cells' abilities to withstand stress, potentially leading to innovative treatments for cancer and other diseases. The company is supported by notable life science investors, positioning it for growth in the biopharmaceutical sector.
Elementary Robotics, Inc. specializes in manufacturing robots designed to assist humans in various industries, including electronics, automotive, medical, and consumer packaged goods. Founded in 2017 and headquartered in Pasadena, California, with additional offices in Mexico and Chicago, the company focuses on automating quality assurance and traceability processes in AI-assisted manufacturing. Its robots are equipped with advanced software, deep learning AI, and camera systems to capture visual data, enabling real-time decision-making and enhancing the efficiency of production lines. By integrating machine learning and computer vision, Elementary Robotics aims to create intelligent automation solutions that improve productivity and streamline workflows in manufacturing and logistics.
Vector Launch, Inc. is a company that develops software for satellites and launch vehicles to facilitate access to space for micro and nano satellites. Founded in 2016 and headquartered in Tucson, Arizona, it operates additional facilities in Long Beach and San Jose, California. The company aims to connect space startups with affordable and frequent launch options, thereby enhancing access to orbital capabilities at unprecedented speeds and price points. Its focus on low-cost microsatellites not only supports commercial innovations but also addresses complex challenges for national security, providing valuable services to the intelligence community and the Department of Defense. However, Vector Launch faced financial difficulties and filed for reorganization under Chapter 11 in December 2019.
Modis Therapeutics is bringing disease-modifying therapies to patients with rare genetic diseases.
MC10, Inc. specializes in the development and sale of wearable medical sensors designed to collect clinical-grade biometric and physiological data, primarily for use in clinical trials. Founded in 2008 and based in Lexington, Massachusetts, the company offers a range of products, including BioStamp nPoint, which processes raw data into clinical metrics such as vital signs and sleep patterns; Kintinuum, an orthopedic rehabilitation device; WiSP, a cardiac monitoring solution; and BioStampMD, a conformable sensor for gathering both objective and subjective health data. MC10 focuses on creating flexible, lightweight electronics that conform to the human body, allowing for discreet and comfortable data collection in various settings. Its proprietary BioStamp system enhances the ability to gather real-world data on muscle activation and movement, thereby advancing digital healthcare services across multiple sectors, including sports and military applications.
Millendo Therapeutics is a biopharmaceutical company dedicated to developing innovative treatments for endocrine diseases resulting from hormone dysregulation. The company focuses on addressing significant unmet medical needs by creating distinct therapies that improve clinical care. By leveraging scientific advancements, Millendo aims to develop novel compounds that can effectively treat complex conditions, ultimately enhancing the quality of life for patients, families, and caregivers.
Infinite Uptime, Inc. offers an integrated industrial solution that combines hardware, cloud analytics, and control software to enhance equipment monitoring and decision-making processes. The company's IoT platform automates predictive maintenance for industrial machines, primarily targeting sectors such as steel, power, cement, chemicals, automotive, and pharmaceuticals. Its industrial data analytics platform (IDAP) identifies patterns in data, assesses overall equipment effectiveness, and detects anomalies in real-time, thereby supporting ISO compliance and monitoring productivity trends. Founded in 2015 and headquartered in Berkeley, California, Infinite Uptime also operates an R&D and technology center in Pune, India, alongside a manufacturing facility in Vadodara, India. The company's innovative approach aims to reduce unplanned downtime, improve overall efficiency, and provide actionable insights into plant performance.
StreetLight Data brings mobility patterns to light for planners, modelers, and engineers by giving them on-demand access to the Big Data resources and processing software for transportation. Their online platform, StreetLight InSight lets its users turn anonymous location data from millions of mobile devices into customized, actionable analytics. It was founded in 2012 and is headquartered in San Francisco, California.
Spero Therapeutics, Inc. is a clinical-stage biopharmaceutical company based in Cambridge, Massachusetts, dedicated to developing innovative treatments for multi-drug resistant (MDR) bacterial infections and rare diseases. The company’s leading product candidate, tebipenem pivoxil hydrobromide, is an oral antibiotic designed to treat MDR Gram-negative infections in adults. Additionally, Spero is advancing SPR206, an intravenous agent targeting MDR Gram-negative infections, and SPR720, an oral antibiotic aimed at treating pulmonary non-tuberculous mycobacterial disease. Spero Therapeutics collaborates with various organizations, including Meiji Seika Pharma for tebipenem HBr, Everest Medicines for SPR206 in Asia, and the Bill & Melinda Gates Medical Research Institute for SPR720. Founded in 2013, Spero leverages a strong team in chemistry and microbiology to address significant unmet medical needs in infectious disease treatment.
Seismos is a data analytics company focused on production optimization through its innovative K-wave technology, which enables real-time monitoring of underground fluid flow during production. Unlike traditional seismic methods, which are time-consuming and costly, Seismos offers a non-invasive, cloud-based solution that provides immediate insights at a significantly lower cost. The company's AI-powered sensing systems utilize advanced acoustic sensing and machine learning to detect and predict anomalies across various sectors, including upstream oil and gas, pipelines, and geothermal markets. By delivering real-time data, Seismos empowers organizations to make informed decisions and enhance operational efficiency without disrupting production processes.
Antiva Biosciences is a biopharmaceutical company based in South San Francisco, California, focused on developing antiviral drugs to treat human papillomavirus (HPV) infections. Founded in 2012 and previously known as Hera Therapeutics, the company aims to prevent cancer by addressing precancerous lesions associated with HPV. Antiva's innovative approach involves localized therapeutics and small molecule antivirals designed to improve health outcomes for patients suffering from diseases linked to HPV and other viruses. The company's clinical programs target high-grade anal intraepithelial neoplasias and high-grade cervical intraepithelial neoplasias, utilizing a medicinal chemistry platform that emphasizes the development and commercialization of direct-acting antivirals.
Embodied, Inc. is a robotics company based in Pasadena, California, established in 2016. It specializes in the development of personal companion robots, notably Moxie, which is designed to engage children in social, emotional, and cognitive development through play-based learning. The company integrates extensive research from the University of Southern California in socially assistive robotics with commercial expertise from the consumer robotics sector. Embodied's mission is to enhance the quality of life for individuals and families by creating interactive, life-like robots that serve as motivators, coaches, and companions, ultimately empowering users to improve their own well-being.
Iconic Therapeutics, Inc. is a biopharmaceutical company focused on developing innovative therapeutics for retinal diseases and cancer by leveraging tissue factor biology in processes such as angiogenesis and inflammation. The company's lead product, ICON-1, is a fusion protein designed to combat vision loss associated with age-related macular degeneration. Additionally, Iconic Therapeutics has developed hI-con1, a novel recombinant protein that targets tissue factor to activate the immune system, facilitating the destruction of pathological blood vessels linked to conditions like wet age-related macular degeneration and certain cancers. This approach not only promotes cell-mediated cytotoxicity but may also help reduce levels of vascular endothelial growth factor (VEGF), which plays a critical role in these diseases. Phase 1 clinical studies of hI-con1 have shown promising results without significant toxicities, indicating dose-related biological activity. Founded in 2002 and headquartered in South San Francisco, California, Iconic Therapeutics aims to transform scientific insights into effective treatments for serious health conditions.
Precision BioSciences, Inc. is a biotechnology company based in Durham, North Carolina, focused on genome editing and the development of therapeutic products. Utilizing its proprietary ARCUS genome editing platform, the company aims to create innovative solutions for human diseases and food applications. Precision BioSciences operates through two primary segments: Therapeutic and Food. The Therapeutic segment is engaged in developing allogeneic CAR T immunotherapies, with several candidates in clinical trials targeting various types of cancers, including acute lymphoblastic leukemia and multiple myeloma. Additionally, the company is involved in in vivo gene correction activities and has collaborations for developing treatments for chronic Hepatitis B. The Food segment concentrates on creating nutrition products. Founded in 2006, Precision BioSciences is dedicated to translating advanced gene editing technology into impactful products across the life sciences.
Ambiq Micro, Inc. specializes in the development of ultra-low power integrated circuits tailored for power-sensitive applications. The company focuses on creating subthreshold power optimized technology, producing real-time clocks and microcontrollers for various uses, including wearables, smart cards, wireless sensors, and Internet-of-Things (IoT) devices. Founded in 2009 and based in Austin, Texas, Ambiq Micro also maintains offices in San Jose, California, and several locations in China. Its pioneering technology aims to facilitate the creation of next-generation wireless electronics by enabling innovative companies to design products that minimize battery dependency, reduce overall power consumption, and enhance design flexibility. Additionally, Ambiq Micro provides technical support services to its clients, further contributing to its mission of advancing low-power semiconductor solutions.
Medisix Therapeutics is a Singapore-based immune engineering company developing novel cellular therapies to address T cell malignancies. Their technology platform originates from world expert in translational immunology, Professor Dario Campana, MD, PhD, a physician scientist who pioneered chimeric antigen receptor T cell (CAR-T) biology. Their programs utilize proprietary immune engineering approaches that enable T cell leukemias and lymphomas to be targeted with cell therapy.
Beam Therapeutics Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing precision genetic medicines using its innovative base editing technology. Founded in 2017, the company aims to provide lifelong cures for patients with serious diseases. Its therapeutic portfolio includes treatments for sickle cell disease, beta-thalassemia, pediatric T-cell acute lymphoblastic leukemia, pediatric acute myeloid leukemia, alpha-1 antitrypsin deficiency, and glycogen storage disorder 1A, as well as therapies for ocular and central nervous system disorders. Beam's base editing technology allows for targeted modifications at a single base in the genome without creating double-stranded breaks in DNA, positioning it as a pioneer in the field of genetic medicine. The company's pipeline includes several programs, such as BEAM-101, ESCAPE, BEAM-302, BEAM-301, and BEAM-201, reflecting its commitment to advancing genetic therapies.
Escient Pharmaceuticals is a biotechnology company based in San Diego, California, that develops and manufactures drugs targeting G protein-coupled receptors (GPCRs) for the treatment of neuro-immuno-inflammatory and autoreactive diseases. Founded in 2017, the company specializes in harnessing the therapeutic potential of specific orphan GPCRs, particularly the Mas-Related G-Protein Receptors (Mrgprs), to address various neurosensory-inflammatory disorders. Escient's innovative approach aims to provide first-in-class therapies for conditions associated with mast cell-mediated disorders and cholestatic pruritus, thereby expanding treatment options for healthcare providers and patients facing these challenging diseases.
Synthorx, Inc. is a biopharmaceutical company based in La Jolla, California, focused on developing innovative cytokine Synthorin programs for the treatment of cancer and autoimmune disorders. The company's lead product candidate, THOR-707, is a variant of recombinant human IL-2 being explored for various solid tumors, both as a standalone treatment and in combination with immune checkpoint inhibitors. Additionally, Synthorx is working on IL-2 Synthorin for autoimmune conditions, IL-10 Synthorin for immuno-oncology, and IL-15 Synthorins to enhance immune regulation. The company employs advanced synthetic biology techniques, utilizing a novel DNA base pair to create proteins with enhanced specificity, safety, and efficacy. These developments enable the manufacturing of improved therapeutics that can better modulate pharmacological properties compared to traditional biologics. Synthorx, which was established in 2014 and previously known as Alinos, Inc., operates as a subsidiary of Sanofi and holds exclusive rights to its innovative synthetic biology technology derived from research at The Scripps Research Institute.