National Institute of Mental Health

Deliberate AI specializes in multimodal artificial intelligence solutions aimed at enhancing mental health clinical trials and healthcare applications. The company focuses on three core areas: advanced diagnostics and monitoring, precision therapy enablement, and ambient clinical intelligence. By utilizing AI-based algorithms, Deliberate AI provides regulatory-grade objective measurement technology tailored for behavioral and mental health care. This platform equips clinicians, physicians, and healthcare researchers with critical data insights, enabling effective diagnostics and continuous monitoring for mental and neurological health challenges. Through its innovative approach, Deliberate AI aims to improve the quality of care and outcomes in mental health and clinical research.

PsychoGenics is a research company offering preclinical testing and research services.

Rumi Scientific is a biotechnology company focused on accelerating the discovery of therapeutics for central nervous system and genetic brain disorders. It has developed an AI-enhanced organoid-like platform that replicates human brain development in vitro, using gene-edited disease models and multicellular self-organization to create defined diseased embryonic tissues. The platform enables high-throughput drug screening and candidate prioritization to identify effective treatments for neurodegenerative and other genetic conditions. By integrating synthetic human embryology with data-driven analysis, the company aims to streamline preclinical drug development and expand options for disorders that currently lack cures.

Innerworld operates as a pioneering mental health platform within the metaverse, specializing in cognitive-behavioral therapy. It offers users a secure virtual environment to foster supportive relationships and acquire evidence-based techniques for managing real-world challenges, with a focus on emotional regulation.

PsychoGenics is a research company offering preclinical testing and research services.

Arcade Therapeutics is a company focused on enhancing mental health through innovative digital therapeutics. Utilizing advanced neuroscientific research, it develops engaging mobile games that serve as accessible tools for mental wellness. The company's platform incorporates a game-like cognitive training algorithm based on attention bias modification, aimed at alleviating anxiety and other disruptive attention-related habits. Additionally, Arcade Therapeutics employs artificial intelligence to gather data and support risk stratification, providing users with a scientifically grounded approach to stress and anxiety management. By merging entertainment with therapeutic interventions, Arcade Therapeutics seeks to offer universal access to effective mental health solutions.

Lyssn develops an artificial intelligence-powered platform for mental health care. It enables users to record psychotherapy conversations, translate them into data, generate transcripts and metrics, and share with professionals for assessment and analysis.

Soterix Medical develops medical devices and accessories for neuromodulation and brain stimulation, including transcranial electrical stimulation and high-definition transcranial electrical stimulation, to provide safe and effective neuromodulation options for clinicians and patients. Based in New York, the company focuses on user-friendly technology that supports clinical and research applications in brain stimulation.

Founded in 2015, Meru Health develops a digital therapeutic program for individuals experiencing stress, depression, anxiety, and other mental health issues. The program, delivered via mobile app, combines licensed clinician support with cognitive behavioral therapy, sleep coaching, and nutrition guidance to improve mental well-being.

Imaginostics develops noninvasive quantitative imaging tools for precision medicine and neurology. Its MRI-based technology provides detailed vascular visualization and quantitative measurements of vascular structure, function, and leakage, using safe contrast alternatives and is compatible with existing MRI scanners. The company offers biomarker solutions to the pharmaceutical industry through contract research organizations and participates in preclinical and clinical research with researchers at leading institutions. Its imaging solutions support the diagnosis and monitoring of neurological disorders, renal conditions, chronic diseases, and acute injuries such as traumatic brain injury or stroke, enabling hospitals to quantify physiology, track disease progression, and assess the effects of drugs on the body.

Mightier is a Boston-based company that develops bioresponsive video games and a family program designed to help children regulate emotions. The platform pairs gameplay with a biofeedback heart rate monitor to adjust game difficulty, encouraging kids to stay calm and in control while learning to recognize and manage emotions in daily life. Created through collaboration with Boston Children's Hospital and Harvard Medical School, Mightier aims to address behavioral and emotional challenges by teaching real-time emotion regulation skills. Founded in 2016, the company offers a program that integrates mind-body signals into interactive experiences, enabling children to practice emotional control through engaging, age-appropriate games.

Camino Pharma is a San Diego-based startup company focused on discovering and developing first-in-class therapies for patients suffering from cancer and CNS disorders. They target signaling proteins based on emerging biological concepts and discover novel mechanisms for modulating these targets with small molecule drugs. Their leadership team has proven expertise in the relevant target biology, as well as extensive experience in drug discovery and development.

Backyard Brains offers affordable neuroscience experiment kits that enable users of all ages to explore electrophysiology, the study of electrical activity in biological systems. Their hands-on tools allow participants to investigate how the brain communicates with senses and muscles, fostering a deeper understanding of neuroscience.

FIRMM is a software-based biofeedback solution, called Framewise Integrated Real-Time MRI Monitoring (FIRMM), for acquiring better brain MR exams.

Cogito enhances emotional intelligence in phone professionals via AI-powered behavioral science. Its software analyzes voice signals during calls, providing real-time coaching for agents and measuring customer experience.

McLean Hospital, established in 1811, is a comprehensive mental health care facility located in Massachusetts and affiliated with Harvard Medical School. It specializes in providing a wide range of high-quality mental health services aimed at improving the lives of individuals and families affected by psychiatric illnesses. With a dedicated staff of over 1,900 professionals, McLean Hospital offers compassionate care and support for patients. As the largest psychiatric teaching facility of Harvard Medical School, it plays a significant role in training future mental health professionals while also engaging in ongoing research to advance the field of psychiatry. The hospital's commitment to mental health care is reflected in its focus on effective, evidence-based treatment and its efforts to foster community outreach and support.

The Brown School offers excellence in social work, public health and social policy graduate education. The school's community of students and scholars dig in every day to work towards social, health, racial and economic equity so that all people can live and thrive. The future of social work and public health depends on leading evidence-based research; moving that research into practice; and preparing students to excel in their work. Brown School faculty excel in these pursuits, and the work they are doing is vital for creating change.

Backyard Brains offers affordable neuroscience experiment kits that enable users of all ages to explore electrophysiology, the study of electrical activity in biological systems. Their hands-on tools allow participants to investigate how the brain communicates with senses and muscles, fostering a deeper understanding of neuroscience.

DFusion is a science-based behavioral health research and development company focused on promoting behavior change to improve health outcomes. The company utilizes evidence-based behavior change models and learning theories to create innovative technology solutions aimed at health, prevention, and adherence. DFusion develops smartphone, tablet, and web applications that enhance user experience while facilitating healthier behaviors. Its team comprises scientists and innovators dedicated to challenging conventional approaches and making a positive impact on health and well-being across various life stages. Based in Scotts Valley and Oakland, California, DFusion also offers consultation services and professional development opportunities in health and education, including the development, testing, evaluation, and dissemination of systems that support the adoption of healthy behaviors.

Backyard Brains offers affordable neuroscience experiment kits that enable users of all ages to explore electrophysiology, the study of electrical activity in biological systems. Their hands-on tools allow participants to investigate how the brain communicates with senses and muscles, fostering a deeper understanding of neuroscience.

Omeros discovers, develops, and commercializes small-molecule and protein therapeutics for large-market and orphan indications targeting inflammation, complement-mediated diseases, disorders of the central nervous system, immunologic disorders, cancers, and addictive/compulsive disorders.

Backyard Brains offers affordable neuroscience experiment kits that enable users of all ages to explore electrophysiology, the study of electrical activity in biological systems. Their hands-on tools allow participants to investigate how the brain communicates with senses and muscles, fostering a deeper understanding of neuroscience.

Acadia Pharmaceuticals is a biopharmaceutical company dedicated to developing and commercializing small molecule drugs targeting unmet medical needs in central nervous system disorders. Its primary product, NUPLAZID (pimavanserin), treats hallucinations and delusions associated with Parkinson's disease psychosis.