National Institute of Mental Health

Deliberate AI focuses on advancing mental health care through its development of multimodal artificial intelligence technologies. The company specializes in regulatory-grade measurement tools that enhance diagnostics and monitoring for behavioral and mental health applications. Their platform employs AI algorithms to deliver objective assessments and insights, supporting clinicians, physicians, and researchers in mental and neurological healthcare and clinical trials. By enabling precision therapy and integrating ambient clinical intelligence, Deliberate AI aims to improve the quality of care and outcomes for patients undergoing mental health treatment.

PsychoGenics is a research company offering preclinical testing and research services.

Rumi Scientific is a research-oriented company focused on developing innovative medications and treatments for genetic disorders affecting the central nervous system, particularly Huntington's Disease. The company utilizes a proprietary human organoid platform that simulates human development in vitro, integrating gene editing techniques with multi-cellular self-organization to create defined diseased embryonic tissues. This advanced platform facilitates drug discovery and high-throughput screening, leveraging artificial intelligence to identify potential treatments. By emphasizing synthetic human embryology in both healthy and diseased contexts, Rumi Scientific aims to advance therapeutic options for numerous genetic conditions that currently lack effective cures. The company's approach combines single-cell, time-lapse imaging with customized analytic tools, resulting in a more efficient and cost-effective drug development process that enhances treatment success rates and outcomes for patients.

Innerworld is a mental health community that operates within the metaverse, offering a virtual reality platform focused on cognitive-behavioral therapy. This innovative platform aims to provide a safe and supportive environment where individuals can build meaningful relationships while learning evidence-based techniques to address real-world mental health challenges. By facilitating the treatment and understanding of mental health disorders, Innerworld enables users to acquire essential skills for emotional regulation and overall well-being.

PsychoGenics is a research company offering preclinical testing and research services.

Arcade Therapeutics is focused on enhancing mental health through innovative mobile gaming solutions. Utilizing groundbreaking neuroscientific research, the company has developed a digital therapeutics platform that offers game-like cognitive training designed to modify attention patterns contributing to anxiety and stress. This platform employs an attention bias modification approach, helping users manage disruptive habits that sustain their mental health challenges. Additionally, Arcade Therapeutics incorporates artificial intelligence to gather data and provide risk stratification, allowing for a scientific approach to mental wellness. By making these therapeutic interventions accessible and engaging, the company aims to improve health outcomes for individuals dealing with behavioral and mental health issues.

Lyssn is a mental health care platform that utilizes artificial intelligence technology to enhance training and quality assurance for mental health professionals. The platform enables users to record and share psychotherapy conversations, transforming these recordings into data through comprehensive transcripts and metrics. This functionality provides valuable feedback to both trainees and experienced counselors, allowing them to assess the emotional states and behaviors of patients effectively. By analyzing health outcomes, Lyssn supports healthcare professionals in improving their practices and fostering better patient care.

Soterix Medical is a New York-based company that specializes in developing medical devices and accessories centered on neuromodulation and brain stimulation technologies. Founded by Abhishek Datta, the company focuses on products that include brain stimulation and transcranial electrical stimulation (tES), as well as high-definition transcranial electrical stimulation (HD-tES). Soterix Medical aims to provide safe, effective, and user-friendly neuromodulation solutions for clinicians and patients.

Meru Health, Inc. is a digital healthcare company that focuses on improving the lives of individuals dealing with mental health issues such as depression, anxiety, and stress. Founded in 2015 and based in San Mateo, California, with additional offices in Palo Alto and Helsinki, Meru Health develops a mobile application that connects users to licensed therapists through a structured 12-week program. This program combines continuous remote clinician support with at-home lessons, cognitive behavioral therapy, and coaching on sleep and nutrition. By offering clinically proven and cost-effective digital therapeutic solutions, Meru Health aims to empower patients and enhance the efficiency of mental health treatment.

Imaginostics specializes in developing advanced diagnostic tools aimed at enhancing precision medicine for clinicians and drug developers. Utilizing proprietary MRI physics-based technology, the company offers significantly improved vascular imaging and quantitative assessments of vascular structure, function, and leakage. This innovative approach not only produces images ten times better than traditional methods but is also compatible with existing MRI scanners and utilizes a safe iron supplement for contrast instead of toxic gadolinium. Imaginostics provides biomarker solutions through collaborations with contract research organizations and engages in pre-clinical and clinical research across various focus areas, working alongside leading researchers at prestigious institutions. The company's noninvasive imaging technology is designed to aid in the diagnosis of neurological disorders, facilitate safe vascular visualization for renal patients, and support acute diagnostics for conditions like traumatic brain injury or stroke, ultimately enabling hospitals to monitor disease progression and evaluate drug effects efficiently.

Mightier is a gaming platform designed to assist children in regulating their emotions through scientifically-backed methods. Founded in 2016 and based in Boston, Massachusetts, the platform features bioresponsive video games developed in collaboration with Boston Children's Hospital and Harvard Medical School. The games utilize a biofeedback heart rate monitor that adjusts the difficulty level based on the player's emotional state, helping children learn to manage their feelings in real-time. By engaging with these interactive experiences, children with behavioral and emotional challenges can discover their emotional strengths and develop skills to harness their emotions in everyday situations.

Camino Pharma is a San Diego-based startup company focused on discovering and developing first-in-class therapies for patients suffering from cancer and CNS disorders. They target signaling proteins based on emerging biological concepts and discover novel mechanisms for modulating these targets with small molecule drugs. Their leadership team has proven expertise in the relevant target biology, as well as extensive experience in drug discovery and development.

Backyard Brains specializes in providing accessible neuroscience tools and experiment kits designed for individuals of all ages to explore brain science. The company offers affordable kits that facilitate hands-on learning about electrophysiology, allowing users—from schoolchildren to graduate students—to conduct experiments similar to those performed by professional neuroscientists. Their products enable participants to record and analyze electrical activity from various biological systems, including motor units and the brain itself. By simplifying complex neuroscience concepts, Backyard Brains empowers everyone to engage in the discovery of how the brain communicates, enhancing understanding of its role in senses, memories, and emotions.

FIRMM is a software-based biofeedback solution, called Framewise Integrated Real-Time MRI Monitoring (FIRMM), for acquiring better brain MR exams.

Cogito is a technology company that specializes in enhancing the emotional intelligence of phone professionals through advanced artificial intelligence and machine learning. By leveraging behavioral science, Cogito's software analyzes various behavioral signals during conversations, offering real-time coaching to agents. This system not only guides agents in their interactions but also provides a continuous assessment of customer experience for each call. Through its innovative approach, Cogito enables enterprises to foster stronger relationships with their customers, improve sales outcomes, and enhance the overall quality of service provided.

McLean Hospital, established in 1811, is a comprehensive mental health care facility located in Massachusetts and affiliated with Harvard Medical School. It specializes in providing a wide range of high-quality mental health services aimed at improving the lives of individuals and families affected by psychiatric illnesses. With a dedicated staff of over 1,900 professionals, McLean Hospital offers compassionate care and support for patients. As the largest psychiatric teaching facility of Harvard Medical School, it plays a significant role in training future mental health professionals while also engaging in ongoing research to advance the field of psychiatry. The hospital's commitment to mental health care is reflected in its focus on effective, evidence-based treatment and its efforts to foster community outreach and support.

The Brown School offers excellence in social work, public health and social policy graduate education. The school's community of students and scholars dig in every day to work towards social, health, racial and economic equity so that all people can live and thrive. The future of social work and public health depends on leading evidence-based research; moving that research into practice; and preparing students to excel in their work. Brown School faculty excel in these pursuits, and the work they are doing is vital for creating change.

Backyard Brains specializes in providing accessible neuroscience tools and experiment kits designed for individuals of all ages to explore brain science. The company offers affordable kits that facilitate hands-on learning about electrophysiology, allowing users—from schoolchildren to graduate students—to conduct experiments similar to those performed by professional neuroscientists. Their products enable participants to record and analyze electrical activity from various biological systems, including motor units and the brain itself. By simplifying complex neuroscience concepts, Backyard Brains empowers everyone to engage in the discovery of how the brain communicates, enhancing understanding of its role in senses, memories, and emotions.

DFusion is a science-based behavioral health research and development company that focuses on promoting behavior change for health, prevention, and adherence. Leveraging evidence-based models and learning theories, DFusion creates innovative applications of both modern and traditional technologies aimed at enhancing health outcomes. The company develops smartphone, tablet, and web applications that are informed by behavioral research, ensuring an optimal user experience. Additionally, DFusion offers consultation services and professional development opportunities within the health and education sectors. Their team, comprised of scientists and innovators, is dedicated to challenging existing paradigms and improving the health and well-being of individuals throughout their lifespans. DFusion operates from offices in Scotts Valley and Oakland, California.

Backyard Brains specializes in providing accessible neuroscience tools and experiment kits designed for individuals of all ages to explore brain science. The company offers affordable kits that facilitate hands-on learning about electrophysiology, allowing users—from schoolchildren to graduate students—to conduct experiments similar to those performed by professional neuroscientists. Their products enable participants to record and analyze electrical activity from various biological systems, including motor units and the brain itself. By simplifying complex neuroscience concepts, Backyard Brains empowers everyone to engage in the discovery of how the brain communicates, enhancing understanding of its role in senses, memories, and emotions.

Omeros Corporation is a Seattle-based biopharmaceutical company that focuses on discovering, developing, and commercializing small-molecule and protein therapeutics targeting inflammation, complement-mediated diseases, and disorders of the central nervous system. The company offers OMIDRIA, a product used during cataract surgery in the United States. Omeros is advancing several clinical programs, including narsoplimab, which is in Phase III trials for conditions such as hematopoietic stem-cell transplant-associated thrombotic microangiopathy and immunoglobulin A nephropathy, as well as Phase II trials for lupus nephritis. Other key programs include OMS405, targeting opioid and nicotine addiction, and OMS527, aimed at treating addiction and movement disorders. The company's preclinical pipeline includes compounds addressing various conditions, such as paroxysmal nocturnal hemoglobinuria and other alternative pathway disorders. Founded in 1994, Omeros is dedicated to addressing both large-market and orphan indications through innovative therapeutic approaches.

Backyard Brains specializes in providing accessible neuroscience tools and experiment kits designed for individuals of all ages to explore brain science. The company offers affordable kits that facilitate hands-on learning about electrophysiology, allowing users—from schoolchildren to graduate students—to conduct experiments similar to those performed by professional neuroscientists. Their products enable participants to record and analyze electrical activity from various biological systems, including motor units and the brain itself. By simplifying complex neuroscience concepts, Backyard Brains empowers everyone to engage in the discovery of how the brain communicates, enhancing understanding of its role in senses, memories, and emotions.

ACADIA Pharmaceuticals Inc. is a biopharmaceutical company dedicated to the development and commercialization of small molecule drugs aimed at addressing unmet medical needs in central nervous system disorders. Founded in 1993 and headquartered in San Diego, California, the company is best known for NUPLAZID (pimavanserin), which is approved for treating hallucinations and delusions associated with Parkinson’s disease psychosis. ACADIA is also advancing pimavanserin as a treatment for dementia-related psychosis and as an adjunctive therapy for schizophrenia, both of which are currently in Phase III clinical trials. Additionally, the company is exploring the use of pimavanserin for major depressive disorder. ACADIA maintains subsidiaries in Sweden and Denmark and is focused on expanding its portfolio of drug candidates, seeking to discover innovative therapies for various neurological and psychiatric conditions.