National Institute of Mental Health

Deliberate AI specializes in multimodal artificial intelligence solutions aimed at enhancing mental health clinical trials and healthcare applications. The company focuses on three core areas: advanced diagnostics and monitoring, precision therapy enablement, and ambient clinical intelligence. By utilizing AI-based algorithms, Deliberate AI provides regulatory-grade objective measurement technology tailored for behavioral and mental health care. This platform equips clinicians, physicians, and healthcare researchers with critical data insights, enabling effective diagnostics and continuous monitoring for mental and neurological health challenges. Through its innovative approach, Deliberate AI aims to improve the quality of care and outcomes in mental health and clinical research.

PsychoGenics is a research company offering preclinical testing and research services.

Rumi Scientific is a research-based company focused on developing medications and innovative treatments for genetic illnesses affecting the central nervous system, with a particular emphasis on Huntington's Disease. The company utilizes a proprietary human organoid platform that simulates human development in vitro, integrating genetic models created through gene editing with multi-cellular self-organization to generate defined diseased embryonic tissues. This platform facilitates drug discovery and high-throughput screening, allowing for the identification of effective treatments using advanced artificial intelligence techniques. By prioritizing synthetic human embryology in both normal and pathological contexts, Rumi Scientific aims to advance therapeutic options for numerous genetic disorders that currently lack viable cures, striving to enhance treatment success rates and improve patient outcomes.

Innerworld operates as a pioneering mental health platform within the metaverse, specializing in cognitive-behavioral therapy. It offers users a secure virtual environment to foster supportive relationships and acquire evidence-based techniques for managing real-world challenges, with a focus on emotional regulation.

PsychoGenics is a research company offering preclinical testing and research services.

Arcade Therapeutics is a company focused on enhancing mental health through innovative digital therapeutics. Utilizing advanced neuroscientific research, it develops engaging mobile games that serve as accessible tools for mental wellness. The company's platform incorporates a game-like cognitive training algorithm based on attention bias modification, aimed at alleviating anxiety and other disruptive attention-related habits. Additionally, Arcade Therapeutics employs artificial intelligence to gather data and support risk stratification, providing users with a scientifically grounded approach to stress and anxiety management. By merging entertainment with therapeutic interventions, Arcade Therapeutics seeks to offer universal access to effective mental health solutions.

Lyssn is a developer of an innovative mental health care platform that leverages artificial intelligence technology to enhance training and quality assurance in psychotherapy. The platform enables users to record and share psychotherapy sessions, transforming these recordings into actionable data. By generating transcripts and metrics, Lyssn provides valuable feedback to both trainees and experienced counselors, facilitating a deeper understanding of patients' emotional states and behaviors. This technology supports healthcare professionals in analyzing health outcomes, ultimately aiming to improve the quality of mental health care services.

Soterix Medical is a New York-based company that specializes in the development of medical devices and accessories focused on neuromodulation and brain stimulation technologies. Founded by Abhishek Datta, the company offers innovative products that include brain stimulation and transcranial electrical stimulation (tES), as well as high-definition transcranial electrical stimulation (HD-tES). Soterix Medical aims to provide safe, effective, and user-friendly neuromodulation solutions for clinicians and patients, enhancing therapeutic outcomes in various medical applications.

Meru Health, Inc. is a digital healthcare company based in San Mateo, California, with additional offices in Palo Alto, California, and Helsinki, Finland. Founded in 2015, it specializes in providing a mobile application that connects patients with licensed therapists through a structured 12-week program aimed at addressing mental health issues such as stress, depression, anxiety, and burnout. The platform combines continuous remote clinician support with at-home lessons and practices, including cognitive behavioral therapy and coaching in sleep and nutrition. By offering cost-effective and clinically proven digital therapeutic solutions, Meru Health empowers individuals to improve their mental well-being while also aiming to reduce overall healthcare costs.

Imaginostics specializes in developing advanced diagnostic tools that enhance precision medicine for clinicians and drug developers. The company utilizes proprietary MRI physics-based technology, which significantly improves vascular imaging and provides quantitative measurements of vascular structure, function, and leakage. This technology is designed to work with standard MRI scanners and employs a non-toxic iron supplement for contrast, avoiding the risks associated with traditional gadolinium-based agents. Imaginostics focuses on noninvasive imaging solutions for various applications, including the diagnosis of neurological disorders, renal patient care, and acute diagnostics for conditions such as traumatic brain injury and stroke. By collaborating with leading researchers and providing biomarker solutions through contract research organizations, Imaginostics aims to accelerate drug development, enhance personalized healthcare, and contribute to the fight against aging.

Mightier is a Boston-based gaming platform established in 2016 that focuses on helping children develop emotional regulation skills through bioresponsive video games. The company's innovative program, developed in collaboration with Boston Children's Hospital and Harvard Medical School, utilizes a heart rate monitor to create a unique gaming experience where the game's difficulty adjusts based on the player's emotional state. This approach allows children to visualize their emotions in real-time, enabling them to learn how to manage their feelings effectively. By engaging with these games, kids with behavioral and emotional challenges can discover their emotional strengths and improve their ability to cope with daily situations.

Camino Pharma is a San Diego-based startup company focused on discovering and developing first-in-class therapies for patients suffering from cancer and CNS disorders. They target signaling proteins based on emerging biological concepts and discover novel mechanisms for modulating these targets with small molecule drugs. Their leadership team has proven expertise in the relevant target biology, as well as extensive experience in drug discovery and development.

Backyard Brains is a company that offers accessible neuroscience tools and experiment kits designed for individuals of all ages to engage in brain science exploration. By providing affordable, hands-on kits, the company empowers students and educators to conduct neurological experiments, allowing them to learn about electrophysiology in a practical manner. Their products enable users to record electrical activity from various biological systems, including motor units and the brain, facilitating a deeper understanding of how the brain communicates and functions. Through simple, guided experiments, Backyard Brains makes it possible for anyone, from schoolchildren to graduate students, to experience the wonders of neuroscience firsthand.

FIRMM is a software-based biofeedback solution, called Framewise Integrated Real-Time MRI Monitoring (FIRMM), for acquiring better brain MR exams.

Cogito is a technology company that specializes in enhancing the emotional intelligence of phone professionals through advanced artificial intelligence and machine learning. By leveraging behavioral science, Cogito's software analyzes various behavioral signals during conversations, offering real-time coaching to agents. This system not only guides agents in their interactions but also provides a continuous assessment of customer experience for each call. Through its innovative approach, Cogito enables enterprises to foster stronger relationships with their customers, improve sales outcomes, and enhance the overall quality of service provided.

McLean Hospital, established in 1811, is a comprehensive mental health care facility located in Massachusetts and affiliated with Harvard Medical School. It specializes in providing a wide range of high-quality mental health services aimed at improving the lives of individuals and families affected by psychiatric illnesses. With a dedicated staff of over 1,900 professionals, McLean Hospital offers compassionate care and support for patients. As the largest psychiatric teaching facility of Harvard Medical School, it plays a significant role in training future mental health professionals while also engaging in ongoing research to advance the field of psychiatry. The hospital's commitment to mental health care is reflected in its focus on effective, evidence-based treatment and its efforts to foster community outreach and support.

The Brown School offers excellence in social work, public health and social policy graduate education. The school's community of students and scholars dig in every day to work towards social, health, racial and economic equity so that all people can live and thrive. The future of social work and public health depends on leading evidence-based research; moving that research into practice; and preparing students to excel in their work. Brown School faculty excel in these pursuits, and the work they are doing is vital for creating change.

Backyard Brains is a company that offers accessible neuroscience tools and experiment kits designed for individuals of all ages to engage in brain science exploration. By providing affordable, hands-on kits, the company empowers students and educators to conduct neurological experiments, allowing them to learn about electrophysiology in a practical manner. Their products enable users to record electrical activity from various biological systems, including motor units and the brain, facilitating a deeper understanding of how the brain communicates and functions. Through simple, guided experiments, Backyard Brains makes it possible for anyone, from schoolchildren to graduate students, to experience the wonders of neuroscience firsthand.

DFusion is a science-based behavioral health research and development company focused on promoting behavior change to improve health outcomes. The company utilizes evidence-based behavior change models and learning theories to create innovative technology solutions aimed at health, prevention, and adherence. DFusion develops smartphone, tablet, and web applications that enhance user experience while facilitating healthier behaviors. Its team comprises scientists and innovators dedicated to challenging conventional approaches and making a positive impact on health and well-being across various life stages. Based in Scotts Valley and Oakland, California, DFusion also offers consultation services and professional development opportunities in health and education, including the development, testing, evaluation, and dissemination of systems that support the adoption of healthy behaviors.

Backyard Brains is a company that offers accessible neuroscience tools and experiment kits designed for individuals of all ages to engage in brain science exploration. By providing affordable, hands-on kits, the company empowers students and educators to conduct neurological experiments, allowing them to learn about electrophysiology in a practical manner. Their products enable users to record electrical activity from various biological systems, including motor units and the brain, facilitating a deeper understanding of how the brain communicates and functions. Through simple, guided experiments, Backyard Brains makes it possible for anyone, from schoolchildren to graduate students, to experience the wonders of neuroscience firsthand.

Omeros Corporation is a Seattle-based biopharmaceutical company that focuses on discovering, developing, and commercializing small-molecule and protein therapeutics targeting inflammation, complement-mediated diseases, and disorders of the central nervous system. The company offers OMIDRIA, a product used during cataract surgery in the United States. Omeros is advancing several clinical programs, including narsoplimab, which is in Phase III trials for conditions such as hematopoietic stem-cell transplant-associated thrombotic microangiopathy and immunoglobulin A nephropathy, as well as Phase II trials for lupus nephritis. Other key programs include OMS405, targeting opioid and nicotine addiction, and OMS527, aimed at treating addiction and movement disorders. The company's preclinical pipeline includes compounds addressing various conditions, such as paroxysmal nocturnal hemoglobinuria and other alternative pathway disorders. Founded in 1994, Omeros is dedicated to addressing both large-market and orphan indications through innovative therapeutic approaches.

Backyard Brains is a company that offers accessible neuroscience tools and experiment kits designed for individuals of all ages to engage in brain science exploration. By providing affordable, hands-on kits, the company empowers students and educators to conduct neurological experiments, allowing them to learn about electrophysiology in a practical manner. Their products enable users to record electrical activity from various biological systems, including motor units and the brain, facilitating a deeper understanding of how the brain communicates and functions. Through simple, guided experiments, Backyard Brains makes it possible for anyone, from schoolchildren to graduate students, to experience the wonders of neuroscience firsthand.

ACADIA Pharmaceuticals Inc. is a biopharmaceutical company dedicated to the development and commercialization of small molecule drugs aimed at addressing unmet medical needs in central nervous system disorders. Founded in 1993 and headquartered in San Diego, California, the company is best known for NUPLAZID (pimavanserin), which is approved for treating hallucinations and delusions associated with Parkinson’s disease psychosis. ACADIA is also advancing pimavanserin as a treatment for dementia-related psychosis and as an adjunctive therapy for schizophrenia, both of which are currently in Phase III clinical trials. Additionally, the company is exploring the use of pimavanserin for major depressive disorder. ACADIA maintains subsidiaries in Sweden and Denmark and is focused on expanding its portfolio of drug candidates, seeking to discover innovative therapies for various neurological and psychiatric conditions.