AbbVie

ThirtyFiveBio is a biotechnology agency focused on developing innovative protein modulators aimed at treating severe gastrointestinal diseases, which represent a significant unmet clinical need. The company specializes in genetically and pharmacologically validated modulators that facilitate a comprehensive drug discovery program. This program is designed to identify small-molecule modulators of specific proteins, with the potential to impact a wide range of digestive system malignancies. By targeting GPR35 signaling, ThirtyFiveBio's approach aims to provide therapeutic options that may help in preventing tumor growth associated with gastrointestinal cancers.

Cephagenix focuses on identifying and developing new, effective migraine therapies.

Light Horse Therapeutics is the gene editing applied to small-molecule drug discovery, pioneering approaches to target the root causes of disabling and life-threatening diseases. Its advanced platform identifies cryptic chemically accessible functional domains within targets that are critical in disease biology. Our initial focus addresses high-value, historically challenging oncology targets with the opportunity to apply the technology to other therapeutic areas in the future.

Nimble Therapeutics is a biotechnology company focused on drug discovery through its innovative maskless chemical synthesis platform. This technology allows for the systematic synthesis and discovery of novel medicines across various therapeutic areas. By leveraging its capabilities, Nimble Therapeutics aims to enhance the empirical optimization of molecules, ultimately enabling medical professionals to develop next-generation peptide therapeutics with improved drug-like properties. The company's approach seeks to transform the landscape of peptide drug discovery and development, providing valuable solutions for the pharmaceutical industry.

Aliada Therapeutics is a biotechnology company focused on developing innovative therapies for central nervous system (CNS) diseases. Founded in 2021 and based in Boston, Massachusetts, the company utilizes its proprietary technology to create specific antibody binders targeting CNS conditions. Through rigorous preclinical evaluation, Aliada aims to advance its therapeutic programs, providing medical professionals with novel treatment options for patients suffering from CNS disorders.

Oisin Biotechnologies is a biotechnology company based in Seattle, Washington, that specializes in developing therapies to address age-related diseases by targeting senescent cells. Founded in 2014, the company focuses on its SENSOlytics platform, which employs a precise, patent-pending approach to selectively clear these cells using DNA expression markers. This innovative strategy aims to mitigate the adverse effects of aging and has been shown to extend lifespan and improve health outcomes. Oisin's lead program is designed to combat frailty by promoting muscle growth without the need for exercise, while additional programs target fat cell reduction and other age-related conditions. The company utilizes a novel non-viral delivery system that ensures effective distribution of both DNA and RNA therapeutics, positioning Oisin Biotechnologies as a leader in rejuvenation biotechnology.

Landos Biopharma, Inc. is a clinical-stage biopharmaceutical company based in Blacksburg, Virginia, specializing in the development of oral therapeutics for autoimmune diseases. Founded in 2017, the company focuses on innovative treatments for conditions such as inflammatory bowel disease (IBD), Crohn's disease, and ulcerative colitis. Its lead product candidate, NX-13, is a novel, gut-selective agonist targeting the NLRX1 pathway. The company also has a diverse pipeline that includes other internally discovered compounds aimed at novel immunometabolic pathways. By developing first-in-class therapeutics, Landos Biopharma seeks to provide effective treatment options for patients suffering from autoimmune conditions.

BaseLaunch is a venture builder firm located in Basel, Switzerland, focused on launching and developing startups across various therapeutic sectors, including oncology, immunology, and cardiovascular health. The program spans 15 months and is divided into two phases, providing non-dilutive funding and access to a network of leading healthcare partners. Participants benefit from the expertise of seasoned advisors and state-of-the-art infrastructure, while being integrated into Basel's vibrant biotech ecosystem. BaseLaunch is supported by prominent industry leaders such as Johnson & Johnson Innovation, Novartis Venture Fund, Pfizer, Roche, and Roivant Sciences, along with various public and private collaborators.

DISCO Pharmaceuticals is a company focused on advancing cancer treatment through its innovative surfaceome mapping platform. This technology enables the identification of proteins and protein communities on the cancer cell surface at a large scale, providing detailed insights that traditional proteomics and genomic methods cannot offer. By unlocking the surfaceome of cancer cells, DISCO Pharmaceuticals aims to facilitate the development of cancer-selective therapies that enhance treatment efficacy while minimizing side effects for patients. The company's approach holds promise for improving patient care by enabling more targeted and effective therapeutic options in oncology.

Cerevel Therapeutics is a clinical-stage biopharmaceutical company focused on developing innovative therapies for neuroscience diseases. Founded in 2018 and headquartered in Cambridge, Massachusetts, the company is advancing a diverse pipeline that includes five clinical-stage investigational therapies and several preclinical compounds targeting conditions such as schizophrenia, epilepsy, Parkinson's disease, and substance use disorder. Key products under development include CVL-231, a positive allosteric modulator for schizophrenia; CVL-865, which is being tested for drug-resistant focal onset epilepsy and acute anxiety; and Tavapadon, a selective dopamine D1/D5 partial agonist for Parkinson's disease. Cerevel Therapeutics employs a unique approach that leverages expertise in neurocircuitry and receptor selectivity to address unmet medical needs in the field of neuroscience.

ImmunoGen, Inc. is a clinical-stage biotechnology company based in Waltham, Massachusetts, specializing in the development of antibody-drug conjugate (ADC) therapies for cancer treatment. The company employs its Targeted Antibody Payload technology to create products that deliver potent cytotoxic agents directly to tumor cells. Notable product candidates include mirvetuximab soravtansine, currently in Phase III clinical trials for platinum-resistant ovarian cancer, and IMGN632, which is in Phase I trials for acute myeloid leukemia and blastic plasmacytoid dendritic cell neoplasm. Additionally, ImmunoGen's preclinical programs feature investigational ADCs such as IMGC936, co-developed with MacroGenics. The company has established collaborations with numerous pharmaceutical firms, enhancing its research and development capabilities. Founded in 1980, ImmunoGen continues to focus on advancing innovative therapies to improve cancer treatment outcomes.

Mozart Therapeutics is a biotechnology startup dedicated to developing disease-modifying therapies for autoimmune and inflammatory diseases. The company focuses on a novel regulatory CD8 T cell network to create innovative CD8 Treg modulators aimed at treating a range of autoimmune conditions. By targeting a specific subset of T-lymphocytes, Mozart aims to restore long-term immune balance and prevent the progression of damage caused by autoreactive immune responses. Its pipeline includes first-in-class CD8 Treg modulators designed to delay the onset of autoimmune diseases and improve patient outcomes through advanced treatment options.

Quanta Therapeutics is a biotechnology company focused on developing innovative cancer therapies targeting driver oncogenes, specifically RAS-driven cancers. The company employs advanced optical technology to discover small molecules that can modulate the conformation of RAS proteins. This allosteric modulation aims to restore conformational control of active RAS signaling at the cell membrane, thereby inhibiting a wide range of cancers associated with RAS mutations. By addressing the challenges of previously untreatable cancers, Quanta Therapeutics is committed to advancing new treatment options for patients and enhancing the understanding of RAS biology in cancer therapy.

Capsida is a biotechnology company focused on developing targeted gene therapies for monogenic and sporadic disorders affecting both the central nervous system and other areas of the body. The company utilizes a proprietary adeno-associated virus (AAV) engineering platform, which creates capsids specifically designed to target particular tissues and cells within affected organs. This advanced approach not only aims to enhance the efficacy of the therapies by ensuring they reach the intended sites of action, but also minimizes the impact on non-target tissues, thereby improving patient health outcomes in the treatment of life-threatening genetic disorders.

Jnana Therapeutics Inc. is a biotechnology company based in Boston, Massachusetts, that focuses on drug discovery through its innovative platform targeting solute carrier (SLC) transporters. Established in 2016, the company aims to improve patient outcomes by developing small molecule therapies for various diseases, including those related to immunometabolism, lysosomal function, and mucosal defense. By utilizing advanced chemoproteomics techniques, Jnana accelerates the identification of therapeutic targets, addressing significant unmet medical needs in areas such as immuno-oncology, inflammatory disorders, and neurological diseases. The company's approach seeks to enhance drug discovery efficiency by comprehensively targeting the vast family of membrane proteins associated with SLC transporters.

DJS Antibodies Ltd, founded in 2014 and based in Bicester, United Kingdom, focuses on the design and discovery of novel therapeutic monoclonal antibodies targeting G-protein-coupled receptors (GPCRs). The company specializes in developing innovative therapeutics aimed at treating chronic inflammatory diseases, utilizing breakthrough technology to create first-in-class antibodies against challenging disease targets. By isolating high-quality antibodies against complex protein targets that have previously proven difficult for drug discovery, DJS Antibodies aims to provide effective treatments for conditions that are currently undruggable and untreatable.

Syndesi Therapeutics SA is a biopharmaceutical company based in Louvain-la-Neuve, Belgium, founded in 2018. The company focuses on developing drug molecules that modulate the synaptic vesicle protein SV2A, which is crucial for synaptic transmission—the process that facilitates communication between neurons in the brain. By regulating this transmission, Syndesi aims to create effective treatments for Alzheimer’s Disease and other cognitive impairment disorders. The company holds an exclusive license to its innovative platform technology from UCB, a leader in SV2A research. Through its efforts, Syndesi Therapeutics seeks to provide healthcare providers with advanced therapeutic options for managing these challenging conditions.

AmbAgon Therapeutics is a biotechnology company focused on developing small-molecule therapeutics for cancer treatment. The company specializes in research aimed at stabilizing the interactions of oncogenic proteins, thereby enhancing the activity of tumor-suppressing proteins. By targeting these proteins, AmbAgon Therapeutics seeks to address significant unmet clinical needs in oncology that conventional treatment methods have struggled to meet. Founded by Christian Ottmann, Lucas Brunsveld, and Michelle Arkin, the company aims to provide innovative solutions in cancer care through its unique approach to drug development.

Nitrase Therapeutics is a biopharmaceutical platform company focused on developing therapies targeting a newly identified class of enzymes known as Nitrases. Initially concentrating on Parkinson’s disease, the company aims to create drugs that may slow or halt the progression of this and other related neurodegenerative conditions. By leveraging its expertise in nitration, Nitrase Therapeutics seeks to explore the therapeutic potential of biochemical modifications of proteins, particularly through the identification of nitro-substrates and their involvement in various diseases. This approach positions the company to potentially expand its platform to address a broader range of medical conditions in the future.

Quanta Therapeutics is a biotechnology company focused on developing innovative cancer therapies targeting driver oncogenes, specifically RAS-driven cancers. The company employs advanced optical technology to discover small molecules that can modulate the conformation of RAS proteins. This allosteric modulation aims to restore conformational control of active RAS signaling at the cell membrane, thereby inhibiting a wide range of cancers associated with RAS mutations. By addressing the challenges of previously untreatable cancers, Quanta Therapeutics is committed to advancing new treatment options for patients and enhancing the understanding of RAS biology in cancer therapy.

The Institute for Family Health is offering mental health, dental care, and social services.

Delaware Valley Community Health operates as a non-profit firm, the firm offers adult & family medicine, pediatrics, dental, etc. services.

Aaron E. Henry Community Health Services Center offers primary and preventive health care services.

Community Hope is helping individuals, including veterans, and their families, overcome mental illness, addiction, homelessness, and poverty by providing housing and support services. Homeless veterans suffering from mental health issues and combat-induced trauma have been able to access their residential programs and support services.

For more than 157 years, Eskenazi Health has offered high-quality, cost-effective and patient-focused health care to the residents of Marion County and Central Indiana. As one of America’s largest essential health-care systems, Eskenazi Health provides treatment and services to nearly 1 million outpatient visitors each year.

The Night Ministry is a nonprofit organization that provides housing, health care, and social services.

MLK Health Center provides general health care services. They offer services in routine physical exams, prescribing necessary medications, treatment of minor illnesses and injuries, managing chronic conditions, screening for common health issues, and management of acute health conditions. They also offer a thorough assessment of patient data, disease data, and medicine-related data where patient-specific medicine-related problems are identified, including ineffective dosages, non-adherence, and adverse drug reactions.

Roanoke Chowan Community Health Center, based in Ahoskie, North Carolina, provides a range of essential health services, including behavioral health, pharmacy, telehealth, clinical care, and pediatric care. The center aims to enhance community health by offering accessible and comprehensive medical services tailored to the needs of its patients. By integrating various healthcare services, Roanoke Chowan Community Health Center plays a vital role in promoting overall wellness and addressing the healthcare needs of the local population.

Health Brigade is a non-profit organization that provides health services. Their services include wellness, health outreach, advocacy, needle exchange, and eligibility for services. They provide adult general medicine, including medical services for diabetes, high blood pressure, asthma, men’s health, psychiatric evaluation and medication, routine cancer screening, and chronic heart disease.

Jnana Therapeutics Inc. is a biotechnology company based in Boston, Massachusetts, that focuses on drug discovery through its innovative platform targeting solute carrier (SLC) transporters. Established in 2016, the company aims to improve patient outcomes by developing small molecule therapies for various diseases, including those related to immunometabolism, lysosomal function, and mucosal defense. By utilizing advanced chemoproteomics techniques, Jnana accelerates the identification of therapeutic targets, addressing significant unmet medical needs in areas such as immuno-oncology, inflammatory disorders, and neurological diseases. The company's approach seeks to enhance drug discovery efficiency by comprehensively targeting the vast family of membrane proteins associated with SLC transporters.

Starday Foods is a company focused on producing healthy and sustainable food products. It emphasizes the use of sustainable practices in its operations, which enhances efficiency and promotes environmentally friendly methods in food and beverage development. The company specializes in creating food items that are low in sugar and free from palm oil and dairy, catering to consumers who seek quality ingredients. By prioritizing sustainable practices, Starday Foods aims to minimize its environmental impact while delivering nutritious options to its customers.

Stemson Therapeutics, LLC is a cell therapy company based in La Jolla, California, focused on addressing hair loss by restoring natural hair through innovative treatments. Founded in 2018, the company utilizes a proprietary process that employs induced pluripotent stem cells (iPSC) to generate new dermal papilla, the essential cells needed for hair follicle regeneration. Its flagship product, the Stemson solution, combines engineered cells with a unique tissue engineering approach to create a sustainable supply of new hair follicles for patients. By providing effective solutions for individuals experiencing hair loss, Stemson Therapeutics aims to alleviate the emotional and social challenges associated with this condition.

Kojin Therapeutics, founded by Stuart Schreiber, Benjamin Cravatt, Stephanie Dougan, and Vasanthi Viswanathan, focuses on advancing a drug discovery platform that links complex cell states to established biochemical processes, specifically ferroptosis, which involves iron-dependent cell death. This innovative approach enables the development of targeted therapies for a wide range of challenging diseases that are often difficult to treat. The company's biology platform aims to identify disease-specific targets, ensuring that patients receive effective treatments tailored to their specific conditions. Kojin Therapeutics is supported by a diverse group of investors, including Polaris Partners, Newpath Partners, and AbbVie, among others.

Capsida is a biotechnology company focused on developing targeted gene therapies for monogenic and sporadic disorders affecting both the central nervous system and other areas of the body. The company utilizes a proprietary adeno-associated virus (AAV) engineering platform, which creates capsids specifically designed to target particular tissues and cells within affected organs. This advanced approach not only aims to enhance the efficacy of the therapies by ensuring they reach the intended sites of action, but also minimizes the impact on non-target tissues, thereby improving patient health outcomes in the treatment of life-threatening genetic disorders.

Mitokinin, Inc. is a biotechnology company based in New York, specializing in the development of small molecule therapeutics aimed at enhancing the activity of PINK1, a protein associated with Parkinson's disease. Founded in 2017, the company is focused on creating kinetin analogs that are optimized for activating PINK1 without disrupting its natural regulation. Mitokinin's team, comprised of neuroscientists, chemists, and pharmacologists, is dedicated to advancing disease-modifying therapies for neurodegenerative conditions, particularly Parkinson's disease. Through its medicinal chemistry efforts, Mitokinin aims to provide innovative treatment options that can improve patient outcomes in the field of neurology.

Carisma Therapeutics is a clinical-stage biotechnology company dedicated to developing innovative immunotherapies for cancer and other serious diseases through its proprietary chimeric antigen receptor macrophage technology. The company focuses on engineering macrophages and monocytes, which are specialized white blood cells, to enhance their ability to infiltrate solid tumors and deliver potent cellular immunotherapy. By leveraging advanced cell engineering techniques, Carisma aims to provide effective treatments that enable patients with solid tumors to benefit from targeted and robust cancer therapies.

Faze Medicines is a biotechnology company founded in 2020 and located in Cambridge, Massachusetts. The company focuses on developing small molecule drugs that target the underlying mechanisms of disease pathology, with initial therapeutic efforts directed towards conditions such as amyotrophic lateral sclerosis (ALS) and myotonic dystrophy type 1 (DM1). Faze Medicines employs advanced screening and proteomics techniques to explore biomolecular condensate interaction networks, which aids in the identification and development of novel therapeutics. Through its innovative approach, Faze aims to provide effective treatments for patients suffering from these challenging diseases.

Year Up is an organization focused on closing the Opportunity Divide for urban young adults by equipping them with essential skills and practical experience. It offers tuition-free, skills-based training programs that prepare participants for professional careers or higher education. Through partnerships with various companies, Year Up provides internships that allow young adults to gain real-world experience while also offering comprehensive job search support. By fostering the development of both hard and soft skills, Year Up empowers its participants to achieve their full potential in the workforce or academic settings.

Enthera is an Italian biotech start-up focused on developing innovative therapeutic solutions for diabetes, gastrointestinal complications, and other intestinal disorders linked by shared biological pathways. Established in October 2016 through a partnership between BiovelocITA and scientists Prof. Paolo Fiorina and Dr. Francesca D’Addio, Enthera aims to address auto-immune disorders by targeting pathways involved in cell apoptosis across the gut, pancreas, and other organs. This approach seeks to enhance treatment options for challenging conditions such as type 1 diabetes and inflammatory bowel disease, thereby contributing to advancements in the management of intractable autoimmune diseases.

Jacobio Pharmaceuticals, established in 2015 in Beijing, China, is a clinical-stage biotech company specializing in the discovery and development of innovative therapies, particularly in oncology. The company aims to address unmet medical needs both in China and globally, focusing on serious diseases such as cancer, autoimmune disorders, and infectious diseases. Founded by experienced executives with a strong track record in the pharmaceutical industry, Jacobio has rapidly built a skilled research and development team of over 100 employees. This team possesses comprehensive capabilities in target discovery, medicinal chemistry, pharmacology, and clinical registration. Jacobio has developed a robust pipeline of 8 to 10 drug candidates, with JAB-3068 being the most advanced program. This candidate targets novel pathways for both immunotherapy and targeted therapies and has entered Phase I clinical trials in the United States, with additional trials planned in China.

Accent Therapeutics, Inc. is a biopharmaceutical company based in Lexington, Massachusetts, focused on developing small molecule therapies for oncology through the innovative field of epitranscriptomics. Founded in 2017, the company explores post-transcriptional chemical modifications of RNA, which play a crucial role in regulating proteins essential for cellular growth and differentiation. By precisely targeting RNA-modifying proteins associated with cancer, Accent Therapeutics aims to translate advanced scientific research into effective treatments for patients, ultimately providing new therapeutic options in the fight against cancer.

Nitrase Therapeutics is a biopharmaceutical platform company focused on developing therapies targeting a newly identified class of enzymes known as Nitrases. Initially concentrating on Parkinson’s disease, the company aims to create drugs that may slow or halt the progression of this and other related neurodegenerative conditions. By leveraging its expertise in nitration, Nitrase Therapeutics seeks to explore the therapeutic potential of biochemical modifications of proteins, particularly through the identification of nitro-substrates and their involvement in various diseases. This approach positions the company to potentially expand its platform to address a broader range of medical conditions in the future.

Quench Bio, Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing therapies for inflammatory diseases through the exploration of gasdermin biology and innate immunity. The company’s lead compounds specifically target and inhibit Gasdermin D, a protein involved in the processes of pyroptosis and NETosis, which play a crucial role in the release of inflammatory cytokines, alarmins, DNA, and neutrophil extracellular traps (NETs). By addressing these pathways, Quench Bio aims to provide relief for patients suffering from severe inflammatory conditions. Originally founded as Project Pyro, the company changed its name to Quench Bio in June 2018.

Inventiva Pharma is a clinical-stage biopharmaceutical company based in France, dedicated to developing oral small molecule therapies for patients with significant unmet medical needs, particularly in fibrosis, lysosomal storage disorders, and oncology. The company specializes in drugs that target nuclear receptors, transcription factors, and epigenetic modulation. Its primary product candidate, lanifibranor, is being developed for the treatment of non-alcoholic steatohepatitis (NASH), a condition currently lacking approved therapies. Inventiva has established a robust pipeline supported by a proprietary discovery engine, a dedicated research and development facility, and a skilled team with extensive experience in drug development. In addition to advancing lanifibranor, the company is also working on several earlier-stage programs aimed at addressing various medical conditions. All operations are conducted in France.

Carisma Therapeutics is a clinical-stage biotechnology company dedicated to developing innovative immunotherapies for cancer and other serious diseases through its proprietary chimeric antigen receptor macrophage technology. The company focuses on engineering macrophages and monocytes, which are specialized white blood cells, to enhance their ability to infiltrate solid tumors and deliver potent cellular immunotherapy. By leveraging advanced cell engineering techniques, Carisma aims to provide effective treatments that enable patients with solid tumors to benefit from targeted and robust cancer therapies.

Mavupharma Inc., founded in 2016 and headquartered in the United States, focuses on developing non-nucleotide, conditional modulators of the STING pathway to address cancer and infectious diseases. As a subsidiary of AbbVie Inc. since July 2019, the company utilizes small molecules to indirectly modulate the STING pathway, harnessing the innate immune system. This approach aims to provide effective oral treatments for cancer patients, enhancing therapeutic options within the medical community.

Allergan plc is a global pharmaceutical company that develops, manufactures, and commercializes a diverse range of branded pharmaceuticals, medical devices, biologics, and regenerative medicine products. The company operates through three primary segments: US Specialized Therapeutics, US General Medicine, and International. Allergan's extensive portfolio includes products across various therapeutic areas, such as medical aesthetics, dermatology, eye care, neuroscience, urology, gastrointestinal health, women's health, and anti-infective treatments. It is particularly known for its flagship product, Botox, along with breast implants and tissue expanders. The company actively collaborates with other organizations to advance its research and development efforts, including partnerships for treating Alzheimer’s disease and other conditions. Allergan was founded in 1950 and has its headquarters in Dublin, Ireland. In 2015, it rebranded from Actavis plc and is currently a subsidiary of AbbVie Inc.

St. Jude Children's Research Hospital, founded in 1962 and located in Memphis, Tennessee, is a non-profit organization dedicated to understanding, treating, and ultimately defeating childhood cancer and other life-threatening diseases. The hospital prioritizes research and treatment aimed at curing and preventing pediatric catastrophic diseases. It manages an endowment fund that supports its strategic initiatives, with assets overseen by a board of governors. St. Jude is committed to ensuring that no patient is ever turned away due to a family's inability to pay, thus emphasizing its mission to advance the health and well-being of children.

Caraway Therapeutics, Inc. is a biotechnology company focused on developing innovative treatments for neurodegenerative diseases through the modulation of mitophagy and autophagy. By targeting genetically defined pathways, the company aims to create small molecules that restore cellular balance and address the underlying mechanisms of diseases such as Parkinson's disease and amyotrophic lateral sclerosis. Founded in 2018 and based in Cambridge, Massachusetts, Caraway Therapeutics seeks to improve the lives of patients affected by these debilitating conditions by leveraging its expertise in cellular degradation processes. The company was previously known as Rheostat Therapeutics, Inc. before rebranding in October 2019.

Ribometrix, Inc. is a biotechnology company based in Durham, North Carolina, focused on discovering and developing small molecule drugs that target functional three-dimensional RNA structures to treat various human diseases. Established in 2014, the company utilizes advanced expertise in RNA structural analysis to identify novel small molecules that can inhibit the production of proteins associated with diseases. Ribometrix's innovative platform combines proprietary RNA structure determination techniques with cutting-edge RNA tools and artificial intelligence capabilities, allowing researchers to effectively analyze and manipulate RNA biology. The company operates scientific offices in a renovated Biolabs space in Durham, along with additional offices in Chapel Hill and Boston.

Paragen Bio is a biotechnology company focused on developing innovative treatments for autoimmune diseases. Its technology aims to address conditions where the immune system attacks healthy tissues and organs, thereby preventing further deterioration and destruction. The company's drug pipeline includes therapies for inflammatory bowel disease and asthma, providing healthcare providers with tools to improve patient outcomes and enhance quality of life. Through its commitment to advancing treatment options, Paragen Bio seeks to make a significant impact in the field of autoimmune disease management.

Carisma Therapeutics is a clinical-stage biotechnology company dedicated to developing innovative immunotherapies for cancer and other serious diseases through its proprietary chimeric antigen receptor macrophage technology. The company focuses on engineering macrophages and monocytes, which are specialized white blood cells, to enhance their ability to infiltrate solid tumors and deliver potent cellular immunotherapy. By leveraging advanced cell engineering techniques, Carisma aims to provide effective treatments that enable patients with solid tumors to benefit from targeted and robust cancer therapies.

Quentis Therapeutics, Inc. is a biotechnology company based in New York, founded in 2016. The company specializes in developing immunotherapies that target endoplasmic reticulum (ER) stress response pathways within the tumor microenvironment. By addressing ER stress, Quentis aims to enhance the immune system's capacity to combat cancer, providing patients with innovative treatment options. Its therapeutic approach focuses on awakening anti-tumor immunity, thereby potentially improving outcomes for individuals facing various forms of cancer.

Jnana Therapeutics Inc. is a biotechnology company based in Boston, Massachusetts, that focuses on drug discovery through its innovative platform targeting solute carrier (SLC) transporters. Established in 2016, the company aims to improve patient outcomes by developing small molecule therapies for various diseases, including those related to immunometabolism, lysosomal function, and mucosal defense. By utilizing advanced chemoproteomics techniques, Jnana accelerates the identification of therapeutic targets, addressing significant unmet medical needs in areas such as immuno-oncology, inflammatory disorders, and neurological diseases. The company's approach seeks to enhance drug discovery efficiency by comprehensively targeting the vast family of membrane proteins associated with SLC transporters.

Ribometrix, Inc. is a biotechnology company based in Durham, North Carolina, focused on discovering and developing small molecule drugs that target functional three-dimensional RNA structures to treat various human diseases. Established in 2014, the company utilizes advanced expertise in RNA structural analysis to identify novel small molecules that can inhibit the production of proteins associated with diseases. Ribometrix's innovative platform combines proprietary RNA structure determination techniques with cutting-edge RNA tools and artificial intelligence capabilities, allowing researchers to effectively analyze and manipulate RNA biology. The company operates scientific offices in a renovated Biolabs space in Durham, along with additional offices in Chapel Hill and Boston.

Palleon Pharmaceuticals is a biotechnology company that develops therapeutics targeting glycan-mediated immune regulation for the treatment of cancer and inflammatory diseases. Founded in 2015 and based in Waltham, Massachusetts, the company specializes in creating glycoimmune checkpoint inhibitors, a novel class of drugs designed to enhance immune response against cancer. By integrating insights from global leaders in glycoscience and human immunology, Palleon aims to provide a broader array of combination therapies that not only address cancer but also combat resistance to traditional immuno-oncology treatments. Additionally, the company develops therapies for inflammatory diseases, including autoimmunity and fibrosis.

Exicure, Inc. is a clinical-stage biotechnology company based in Chicago, Illinois, focused on developing therapeutics utilizing its proprietary spherical nucleic acid (SNA) technology. The company aims to address a range of conditions, including neurological disorders, immuno-oncology, inflammatory diseases, and genetic disorders. Its lead drug candidate, AST-008, is currently undergoing Phase 1b/2 clinical trials for advanced solid tumors. Additionally, Exicure is advancing XCUR-FXN, an SNA-based therapeutic for Friedreich’s ataxia in preclinical trials, and XCUR17, which targets the mRNA encoding interleukin 17 receptor alpha. The company has established collaborations with Allergan Pharmaceuticals to develop SNA-based treatments for hair loss and with DERMELIX, LLC for research and commercialization efforts related to netherton syndrome. Founded in 2011, Exicure is developing a new class of immunomodulatory and gene silencing drugs that enhance the delivery and efficacy of nucleic acid therapeutics.

Disarm Therapeutics, Inc. is a biotechnology company focused on developing therapeutics for patients suffering from neurological diseases. Founded in 2016 and headquartered in Cambridge, Massachusetts, the company aims to create disease-modifying drugs that prevent axonal degeneration, which is a key factor in various neurological disorders. Disarm's portfolio addresses conditions such as multiple sclerosis, amyotrophic lateral sclerosis, glaucoma, and peripheral neuropathies, providing potential treatments for acute diseases affecting the central, ocular, and peripheral nervous systems. As of late 2020, Disarm Therapeutics operates as a subsidiary of Eli Lilly and Company.

Rodeo Therapeutics Corp. is a drug development company based in Seattle, Washington, focused on creating novel small molecule therapies aimed at treating inflammatory bowel disease and enhancing blood cell reconstitution after bone marrow transplants. Founded in 2017, the company specializes in targeting specific enzymes and biological pathways that are vital for tissue repair and regeneration. Its therapies work by increasing tissue levels of prostaglandin PGE2 through the inhibition of a prostaglandin-degrading enzyme, thereby facilitating tissue regeneration and protecting against conditions such as colitis. Rodeo Therapeutics is dedicated to advancing treatments that improve patient outcomes in various medical conditions related to tissue damage and recovery.

Carisma Therapeutics is a clinical-stage biotechnology company dedicated to developing innovative immunotherapies for cancer and other serious diseases through its proprietary chimeric antigen receptor macrophage technology. The company focuses on engineering macrophages and monocytes, which are specialized white blood cells, to enhance their ability to infiltrate solid tumors and deliver potent cellular immunotherapy. By leveraging advanced cell engineering techniques, Carisma aims to provide effective treatments that enable patients with solid tumors to benefit from targeted and robust cancer therapies.

Aquinnah Pharmaceuticals, Inc. is a pharmaceutical company based in Cambridge, Massachusetts, established in 2014. The company specializes in developing therapies for amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. Aquinnah's research focuses on modulating neurodegenerative stress granules, which are thought to play a significant role in the pathology of ALS. Through its innovative approach, Aquinnah aims to address critical unmet medical needs in the treatment of these debilitating conditions.

ApoGen Biotechnologies, Inc., founded in 2014 and located in Seattle, Washington, is dedicated to developing innovative therapeutics aimed at addressing the challenges of cancer treatment, particularly the issue of drug resistance. The company focuses on targeting the key drivers of genomic mutations in cancer cells, which are central to tumor evolution and the development of resistance to existing therapies. By addressing the chronic mutations in cancer genomes, ApoGen aims to improve treatment efficacy, reduce cancer recurrence and metastasis, and enhance overall patient survival. The company's approach represents a shift from traditional therapies, providing new hope in the ongoing battle against cancer.

Artios Pharma Limited is a biotechnology company based in Cambridge, United Kingdom, that specializes in developing innovative cancer treatments targeting DNA damage response (DDR) pathways. Founded in 2015, the company is dedicated to creating first-in-class therapies aimed at selectively killing cancer cells. Artios's product pipeline features several promising programs, including a focus on DNA polymerase theta (Polθ), which plays a crucial role in DNA repair processes. Additionally, the company is advancing an in-licensed program that targets a newly identified protein linked to DDR and is developing a novel treatment aimed at DNA nucleases involved in these pathways. Artios collaborates with Cancer Research Technology and prominent DNA repair researchers globally to enhance its research and development efforts.

Morphic Therapeutic is a biotechnology company focused on developing oral integrin therapies aimed at treating serious chronic diseases such as autoimmune disorders, cardiovascular conditions, metabolic diseases, fibrosis, and cancer. The company specializes in creating small molecule inhibitors that target various integrins. By leveraging insights into integrin biology, Morphic Therapeutic is building a pipeline of innovative therapeutics designed to address a range of immunological, fibrotic, neoplastic, and vascular diseases, thereby offering potential new treatment options for patients with significant unmet medical needs.

Stemcentrx is a biotechnology company focused on developing innovative therapies aimed at curing cancer and significantly enhancing patient survival rates. Founded in 2008 by Brian Slingerland and Scott J. Dylla, the company is headquartered in South San Francisco, California. Stemcentrx specializes in disease-specific treatments that target tumors at their source, specifically by eliminating cancer stem cells, which are responsible for initiating and sustaining tumor growth. This approach helps healthcare providers offer more effective solutions to their patients. In June 2016, Stemcentrx became a subsidiary of AbbVie, furthering its capabilities in cancer research and drug development.

Lodo Therapeutics Corporation is a drug discovery and development company dedicated to creating novel therapeutics derived from natural sources. It focuses on addressing significant health challenges, particularly resistant infectious diseases and cancers, by collaborating with global pharmaceutical companies and leading non-governmental organizations. Founded to realize the scientific vision of Dr. Sean Brady from Rockefeller University, Lodo Therapeutics utilizes a genome-based, culture-independent platform to discover and characterize small molecules sourced from environmental microbial DNA. This innovative approach leverages advancements in DNA sequencing and bioinformatics to explore the untapped potential of microbial evolution, aiming to identify therapeutically valuable pharmaceutical products. Headquartered in New York City at the Alexandria Center for Life Science, Lodo Therapeutics is committed to harnessing the power of nature in the fight against undruggable targets and high unmet medical needs.

Alector, Inc. is a clinical-stage biopharmaceutical company focused on developing novel therapies for neurodegenerative diseases, including Alzheimer’s disease and frontotemporal dementia. Founded in 2013 and headquartered in South San Francisco, California, the company utilizes advanced antibody technology and insights from neuroimmunology and human genetics to create innovative treatments. Alector’s pipeline includes several candidates, such as AL001, which is undergoing phase II clinical trials for frontotemporal dementia, and AL101, currently in phase I trials for Alzheimer's and Parkinson's diseases. Additionally, AL002 and AL003 are in phase 1b trials for Alzheimer’s disease. The company is actively engaged in research and development, with a total of ten programs at various stages. Alector has formed a strategic collaboration with Adimab, LLC to enhance its antibody research and development capabilities, aiming to efficiently generate and validate antibody drugs that target key disease-related mechanisms.

Petra Pharma Corporation is a clinical-stage pharmaceutical company based in New York that focuses on discovering and developing therapies targeting phosphoinositide (PI) signaling pathways. Established in 2015, the company aims to create novel small molecules that address serious medical conditions, particularly cancer and metabolic diseases. By honing in on unique enzyme targets involved in critical cellular processes such as cell division, growth, trafficking, and signaling, Petra Pharma seeks to develop innovative treatments that can enhance human health and provide new options for healthcare providers.

Pharmacyclics LLC is a biopharmaceutical company headquartered in Sunnyvale, California, that specializes in developing and commercializing innovative therapies for cancer and immune-mediated diseases. Founded in 1991, the company is known for its flagship product, IMBRUVICA, which is a first-in-class oral therapy approved for various types of blood cancers, including chronic lymphocytic leukemia and mantle cell lymphoma. In addition to IMBRUVICA, Pharmacyclics is engaged in the development of several other therapeutic candidates, including a BTK inhibitor currently in multiple phases of clinical trials targeting various malignancies and autoimmune conditions. The company also has ongoing projects involving an HDAC inhibitor for relapsed lymphomas and solid tumors, as well as a Factor VIIa inhibitor for cancer treatment. Pharmacyclics operates as a subsidiary of AbbVie Inc. and collaborates with Janssen Biotech, Inc. to enhance its oncology portfolio.

AM Pharma B.V. is a biopharmaceutical company based in Bunnik, the Netherlands, focused on developing and commercializing novel therapeutics for inflammatory and infectious diseases. Established in 2000, the company specializes in pre-clinical and clinical development using endogenous proteins and peptides derived from the human body. Its key products include alkaline phosphatase, aimed at treating acute kidney injury and ulcerative colitis, and the immune response amplifying peptide hLF1-11, which targets drug-resistant hospital-acquired infections. AM Pharma is committed to providing innovative therapies that enhance patient quality of life by addressing critical medical needs.

Virobay Inc. is a clinical-stage biopharmaceutical company based in Menlo Park, California, focused on developing and commercializing novel therapies for various medical conditions, including neuropathic pain, autoimmune diseases, liver fibrosis, cancer, and Alzheimer's disease. The company's pipeline includes VBY-129, a cathepsin S inhibitor aimed at treating neuropathic pain and Crohn's disease, and VBY-376, an orally-administered cathepsin B inhibitor for liver fibrosis associated with nonalcoholic steatohepatitis. Additionally, VBY-825 is designed to inhibit multiple cathepsins to mitigate autoimmune attacks on bile ducts and reverse fibrosis. Virobay has also licensed VBY-891 to LEO Pharma A/S for specific dermatological uses, such as psoriasis. Founded in 2006, Virobay is dedicated to addressing significant unmet medical needs through its cysteine cathepsin platform, which focuses on developing safer and more effective treatments by regulating essential cellular processes.

Kala Pharmaceuticals, Inc. is a biopharmaceutical company dedicated to developing and commercializing innovative therapies for eye diseases using its proprietary Mucus Penetrating Particles (MPP) technology. This technology enhances drug distribution and pharmacokinetics by coating mucosal surfaces with biocompatible, drug-loaded particles, allowing for improved local drug concentrations while minimizing systemic exposure. Kala's lead product candidate, KPI-121 0.25%, has completed two Phase III clinical trials aimed at providing temporary relief for dry eye disease. Additionally, INVELTYS has also completed two Phase III trials for managing inflammation and pain after ocular surgery. The company is advancing KPI-285, a receptor tyrosine kinase inhibitor, in preclinical studies targeting retinal diseases. Established in 2009 and headquartered in Watertown, Massachusetts, Kala Pharmaceuticals continues to explore diverse product opportunities while focusing on internal development and research collaborations to address significant clinical needs.

ImmuVen is a biotechnology company focused on discovering and developing innovative biotherapeutics aimed at treating infectious diseases, cancer, and autoimmune disorders. The company utilizes a unique platform that facilitates the rapid selection and optimization of soluble T cell receptor (TCR) receptors. This technology enhances the ability of healthcare providers to effectively treat patients by improving therapeutic options. Through its advancements in biotherapeutics, ImmuVen seeks to address significant medical challenges in various disease areas.

Exicure, Inc. is a clinical-stage biotechnology company based in Chicago, Illinois, focused on developing therapeutics utilizing its proprietary spherical nucleic acid (SNA) technology. The company aims to address a range of conditions, including neurological disorders, immuno-oncology, inflammatory diseases, and genetic disorders. Its lead drug candidate, AST-008, is currently undergoing Phase 1b/2 clinical trials for advanced solid tumors. Additionally, Exicure is advancing XCUR-FXN, an SNA-based therapeutic for Friedreich’s ataxia in preclinical trials, and XCUR17, which targets the mRNA encoding interleukin 17 receptor alpha. The company has established collaborations with Allergan Pharmaceuticals to develop SNA-based treatments for hair loss and with DERMELIX, LLC for research and commercialization efforts related to netherton syndrome. Founded in 2011, Exicure is developing a new class of immunomodulatory and gene silencing drugs that enhance the delivery and efficacy of nucleic acid therapeutics.