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AmbAgon Therapeutics is a developer of cancer molecule therapeutics. The company offers research of a small molecule that augments a tumor-suppressing protein. AmbAgon Therapeutics was founded by Christian Ottmann, Lucas Brunsveld, and Michelle Arkin.

Nitrase Therapeutics is a biopharmaceutical company focused on discovering and developing drugs targeting a newly identified class of enzymes known as Nitrases. Initially concentrating on Parkinson’s disease, Nitrase aims to create therapies that may slow or halt the progression of this neurodegenerative condition. Beyond its primary focus, the company plans to expand its research to address other aging-related diseases, including Type II diabetes, heart disease, and various cancer types. Founded in 2012 and headquartered in Jackson, Wyoming, with additional facilities in San Francisco, California, Nitrase Therapeutics is positioned to contribute significantly to the treatment of complex diseases associated with aging.

Quanta is a biotechnology company uncovering novel cancer therapeutic candidates using allosteric modulation to target driver oncogenes. The company was founded in 2018 and is based in San Francisco, CA.

For more than 157 years, Eskenazi Health has offered high-quality, cost-effective and patient-focused health care to the residents of Marion County and Central Indiana. As one of America’s largest essential health-care systems, Eskenazi Health provides treatment and services to nearly 1 million outpatient visitors each year.

Jnana Therapeutics Inc. is a Boston-based company founded in 2016 that operates a drug discovery platform centered on solute carrier (SLC) transporters. The company focuses on key disease pathways related to immunometabolism, lysosomal function, and mucosal defense, targeting areas such as immuno-oncology, inflammatory disorders, and neurological diseases. By leveraging its innovative approach, Jnana Therapeutics aims to discover and develop transformative medicines that address significant medical needs and improve patient outcomes.

Starday Foods is a healthy and sustainable food products company.

Stemson Therapeutics, LLC operates as a cell therapy company that helps to restore natural hair. The company produces cells required to regenerate hair follicles using the novel cell engineering process. Its products include the stemson solution, a solution that generates novo follicles using induced pluripotent stem cells (iPSC) to grow new Dermal Papilla. The company was founded in 2018 and is based in LA Jolla, California.

Founded by Stuart Schreiber, Benjamin Cravatt, Stephanie Dougan, and Vasanthi Viswanathan, Kojin is accelerating a drug discovery platform that connects complex cell states to known biochemical processes such as ferroptosis, or iron-dependent cell death, and enables the development of selective therapies for a broad range of hard-to-treat diseases. The company’s investors include Polaris Partners, Newpath Partners, Cathay Health, Leaps by Bayer, AbbVie Inc., Eventide Asset Management, Alexandria, and the Dana-Farber Cancer Institute venture firm, Binney Street Capital.

Capsida is a biotechnology company focused on developing targeted gene therapies for monogenic and sporadic disorders affecting both the central nervous system and other areas of the body. The company utilizes a proprietary adeno-associated virus (AAV) engineering platform, which creates capsids specifically designed to target particular tissues and cells within affected organs. This advanced approach not only aims to enhance the efficacy of the therapies by ensuring they reach the intended sites of action, but also minimizes the impact on non-target tissues, thereby improving patient health outcomes in the treatment of life-threatening genetic disorders.

Mitokinin, Inc. is a biotechnology company operating in the healthcare sector, established in 2017 and located in New York, New York. The company is engaged in medicinal chemistry efforts aimed at generating kinetin analogs that are specifically optimized to activate PINK1, a protein associated with cellular health. Mitokinin's primary focus is the development of these analogs or their optimized variants as potential treatments for Parkinson's disease, a neurodegenerative condition. The company strives to advance its research in order to contribute to effective therapeutic options for this challenging illness.

Carisma Therapeutics is a biotechnology company focused on developing innovative cellular immunotherapies to treat solid tumors. Founded in 2016 and based in Philadelphia, Pennsylvania, the company specializes in creating CAR macrophages, which utilize chimeric antigen receptor technology and adoptive cell transfer. This approach aims to enhance cancer treatment by enabling macrophages to infiltrate solid tumor microenvironments, thereby providing robust cellular immunotherapy options for patients. Carisma leverages advancements in macrophage biology and engineering to improve therapeutic outcomes in oncology.

Faze Medicines, a pharmaceutical company, develops interventions against driver of disease pathology. It develops small molecule drugs for initial therapeutic focus areas, such as amyotrophic lateral sclerosis and myotonic dystrophy type 1. The company was founded in 2020 and is based in Cambridge, Massachusetts.

Year Up's mission is to close the Opportunity Divide by providing urban young adults with the skills, experience, and support that will empower them to reach their potential through professional careers and higher education.

Palleon Pharmaceuticals Inc., a biotechnology company, focuses on developing drugs that target glycan-mediated immune regulation to treat cancer and inflammatory diseases. It offers therapeutics to treat cancer and inflammatory diseases. The company also develops drugs for inflammatory diseases, such as autoimmunity and fibrosis. Palleon Pharmaceuticals Inc. was formerly known as Palleon Pharma Inc. and changed its name to Palleon Pharmaceuticals Inc. in February 2017. The company was founded in 2015 and is based in Waltham, Massachusetts.

Enthera S.r.l. is a biotechnology company based in Milan, Italy, founded in 2016. The company focuses on developing innovative therapeutic approaches for diabetes and related gastrointestinal complications, particularly enteropathy, along with other intestinal disorders that share similar biological pathways. Enthera operates a monoclonal antibody discovery platform to create first-in-class biologics aimed at addressing these underserved conditions. The company was established as a subsidiary of BiovelocITA S.r.l. and was founded in collaboration with scientists Prof. Paolo Fiorina and Dr. Francesca D’Addio. The name "Enthera" is derived from a combination of the terms "entero," referring to the intestine, and "therapy," reflecting its commitment to developing targeted treatments.

Jacobio Pharmaceuticals Co., Ltd., a clinical-stage pharmaceutical company, focusing on the in-house discovery and development of oncology therapies. Its lead drug development programs include two clinical-stage allosteric SHP2 inhibitors, including JAB-3068, a SHP2 inhibitor for the treatment of patients with solid tumor; and JAB-3312, an oral small molecule anti-tumor agent. The company was founded in 2015 and is based in Beijing, China. Jacobio Pharmaceuticals Co., Ltd. is a subsidiary of Jacobio (HK) Pharmaceuticals Co., Limited.

Accent Therapeutics, Inc. is a biopharmaceutical company based in Lexington, Massachusetts, focused on developing small molecule therapies for oncology through the innovative field of epitranscriptomics. Founded in 2017, the company explores post-transcriptional chemical modifications of RNA, which play a crucial role in regulating proteins essential for cellular growth and differentiation. By precisely targeting RNA-modifying proteins associated with cancer, Accent Therapeutics aims to translate advanced scientific research into effective treatments for patients, ultimately providing new therapeutic options in the fight against cancer.

Nitrase Therapeutics is a biopharmaceutical company focused on discovering and developing drugs targeting a newly identified class of enzymes known as Nitrases. Initially concentrating on Parkinson’s disease, Nitrase aims to create therapies that may slow or halt the progression of this neurodegenerative condition. Beyond its primary focus, the company plans to expand its research to address other aging-related diseases, including Type II diabetes, heart disease, and various cancer types. Founded in 2012 and headquartered in Jackson, Wyoming, with additional facilities in San Francisco, California, Nitrase Therapeutics is positioned to contribute significantly to the treatment of complex diseases associated with aging.

Quench Bio is a developer of gasdermin biology drugs designed to treat severe inflammatory diseases.The company leverages insights into gasdermin biology and innate immunity to develop medicines with lead compounds that target and inhibit the pore-forming protein that mediates the release of inflammatory cytokines, alarmins, DNA and NETs, enabling patients to get relief from inflammatory diseases.

Inventiva Pharma is a clinical-stage biopharmaceutical company focused on the development of oral small molecule therapies for the treatment of patients with significant unmet medical needs in the areas of fibrosis, lysosomal storage disorders and oncology. They have built a pipeline backed by a discovery engine with an extensive library of proprietary molecules, a wholly-owned research and development facility and a team with significant expertise and deep experience in the development of compounds that target nuclear receptors, transcription factors and epigenetic modulation. Leveraging these assets and expertise, they are advancing two clinical candidates in three indications, as well as a deep pipeline of earlier stage programs.

Carisma Therapeutics is a biotechnology company focused on developing innovative cellular immunotherapies to treat solid tumors. Founded in 2016 and based in Philadelphia, Pennsylvania, the company specializes in creating CAR macrophages, which utilize chimeric antigen receptor technology and adoptive cell transfer. This approach aims to enhance cancer treatment by enabling macrophages to infiltrate solid tumor microenvironments, thereby providing robust cellular immunotherapy options for patients. Carisma leverages advancements in macrophage biology and engineering to improve therapeutic outcomes in oncology.

Mavupharma Inc., founded in 2016 and based in the United States, focuses on the development of innovative therapies aimed at treating cancer and infectious diseases. The company is engaged in creating non-nucleotide, conditional modulators of the STING pathway, which plays a crucial role in the immune response. As of July 2019, Mavupharma operates as a subsidiary of AbbVie Inc., benefiting from the larger organization's resources and expertise in the pharmaceutical industry.

Allergan, is a multi-specialty health care company focused on discovering, developing and commercializing innovative pharmaceuticals, biologics and medical devices that enable people to live life to its greatest potential to see more clearly, move more freely, express themselves more fully.

St. Jude Children's Research Hospital, founded in 1962 and located in Memphis, Tennessee, is a non-profit organization dedicated to understanding, treating, and ultimately defeating childhood cancer and other life-threatening diseases. The hospital prioritizes research and treatment aimed at curing and preventing pediatric catastrophic diseases. It manages an endowment fund that supports its strategic initiatives, with assets overseen by a board of governors. St. Jude is committed to ensuring that no patient is ever turned away due to a family's inability to pay, thus emphasizing its mission to advance the health and well-being of children.

Rheostat’s mission is to invent novel treatments for neurodegenerative disease through modulation of mitophagy and autophagy. They believe that the degradation of toxic cellular components, whether they are damaged organelles or aggregated proteins, is a fundamental node of biology. Mutations that impair these clearance pathways cause multiple neurodegenerative diseases, many of which are associated with cognitive impairment. They aim to leverage our understanding of these critical pathways to discover and develop novel small molecules that will restore cellular balance and treat neurodegenerative and rare diseases.

Ribometrix is a platform therapeutics company that discovers small molecule drugs that target functional 3D RNA structures to treat human diseases. Our scientific offices are located in the newly renovated Biolabs Space in Durham, with offices in Chapel Hill and Boston.

Paragen Bio is a provider of a technology intended to treat autoimmune diseases. The company's technology helps in treating diseases which causes the immune system to attack healthy tissues and organs, enabling doctors to stop the deterioration and complete destruction of tissue.

Magnolia Neurosciences Corporation is a New York-based company focused on drug discovery and development, specifically targeting neuroprotective therapies for central nervous system diseases and neurodegeneration. Established in 2018, the company aims to create proprietary small molecule therapeutics that prevent neuronal cell death, offering new treatment options for patients with neurodegenerative disorders and related conditions. Magnolia Neurosciences was founded to advance technologies developed at The University of Texas MD Anderson Cancer Center’s Therapeutics Discovery Division and the Neurodegeneration Consortium. Through its innovative approach, the company seeks to address significant medical needs in the field of neurology.

Artios Pharma Limited is a biotechnology company based in Cambridge, United Kingdom, focused on developing innovative cancer treatments that target DNA damage response (DDR) pathways. Founded in 2015, the company aims to create first-in-class therapies that selectively kill cancer cells by exploiting the mechanisms involved in DNA repair. Its product pipeline features several promising candidates, including DNA polymerase theta (Polθ) and an in-licensed program targeting a novel DDR protein. Artios collaborates with Cancer Research Technology and leading researchers in the field to advance its development efforts. The company's leadership comprises experts with extensive experience in DDR drug discovery, and it has garnered investment from notable entities, including SV Life Sciences and AbbVie Ventures.

Carisma Therapeutics is a biotechnology company focused on developing innovative cellular immunotherapies to treat solid tumors. Founded in 2016 and based in Philadelphia, Pennsylvania, the company specializes in creating CAR macrophages, which utilize chimeric antigen receptor technology and adoptive cell transfer. This approach aims to enhance cancer treatment by enabling macrophages to infiltrate solid tumor microenvironments, thereby providing robust cellular immunotherapy options for patients. Carisma leverages advancements in macrophage biology and engineering to improve therapeutic outcomes in oncology.

Quentis Therapeutics, Inc. is a biotechnology company founded in 2016 and headquartered in New York, New York. The company specializes in developing cancer immunotherapies that target endoplasmic reticulum (ER) stress response pathways within the tumor microenvironment. By modulating these pathways, Quentis Therapeutics aims to enhance the immune system's capacity to combat cancer, providing patients with innovative treatment options. The company's focus on addressing ER stress contributes to the development of therapeutics intended to improve outcomes for individuals suffering from various forms of cancer.

Jnana Therapeutics Inc. is a Boston-based company founded in 2016 that operates a drug discovery platform centered on solute carrier (SLC) transporters. The company focuses on key disease pathways related to immunometabolism, lysosomal function, and mucosal defense, targeting areas such as immuno-oncology, inflammatory disorders, and neurological diseases. By leveraging its innovative approach, Jnana Therapeutics aims to discover and develop transformative medicines that address significant medical needs and improve patient outcomes.

Ribometrix is a platform therapeutics company that discovers small molecule drugs that target functional 3D RNA structures to treat human diseases. Our scientific offices are located in the newly renovated Biolabs Space in Durham, with offices in Chapel Hill and Boston.

Palleon Pharmaceuticals Inc., a biotechnology company, focuses on developing drugs that target glycan-mediated immune regulation to treat cancer and inflammatory diseases. It offers therapeutics to treat cancer and inflammatory diseases. The company also develops drugs for inflammatory diseases, such as autoimmunity and fibrosis. Palleon Pharmaceuticals Inc. was formerly known as Palleon Pharma Inc. and changed its name to Palleon Pharmaceuticals Inc. in February 2017. The company was founded in 2015 and is based in Waltham, Massachusetts.

Exicure, Inc. is a clinical-stage biotechnology company focused on developing therapeutics for a range of conditions, including neurology, immuno-oncology, inflammatory diseases, and genetic disorders, utilizing its unique spherical nucleic acid (SNA) technology. The company's lead drug candidate, AST-008, is currently undergoing Phase 1b/2 clinical trials for advanced solid tumors. Additionally, Exicure is advancing XCUR-FXN, an SNA-based therapeutic in preclinical trials for Friedreich’s ataxia, and XCUR17, which targets messenger RNA associated with interleukin 17 receptor alpha. Exicure has established collaborations, including an agreement with Allergan Pharmaceuticals for developing SNA-based treatments for hair loss disorders and a partnership with DERMELIX, LLC for research and commercialization aimed at treating Netherton syndrome. Founded in 2011 and headquartered in Chicago, Illinois, Exicure is pioneering a new class of immunomodulatory and gene silencing drugs that enhance the delivery of nucleic acid therapeutics across various tissues.

Disarm Therapeutics is a biotechnology company focused on developing disease-modifying therapeutics for patients suffering from neurological diseases characterized by axonal degeneration. Founded in 2016 and based in Cambridge, Massachusetts, the company aims to prevent axon loss and address conditions such as multiple sclerosis, amyotrophic lateral sclerosis, glaucoma, and peripheral neuropathies. Its innovative approach allows for the treatment of acute diseases affecting the central, ocular, and peripheral nervous systems. As of October 2020, Disarm Therapeutics operates as a subsidiary of Eli Lilly and Company.

Rodeo Therapeutics is a drug development company based in Seattle, Washington, established in 2017. The company specializes in creating novel small molecule therapies aimed at treating inflammatory bowel disease and enhancing blood cell reconstitution after bone marrow transplants. Additionally, Rodeo Therapeutics focuses on developing treatments that promote tissue repair and regeneration by targeting specific enzymes and biological pathways critical to these processes.

Carisma Therapeutics is a biotechnology company focused on developing innovative cellular immunotherapies to treat solid tumors. Founded in 2016 and based in Philadelphia, Pennsylvania, the company specializes in creating CAR macrophages, which utilize chimeric antigen receptor technology and adoptive cell transfer. This approach aims to enhance cancer treatment by enabling macrophages to infiltrate solid tumor microenvironments, thereby providing robust cellular immunotherapy options for patients. Carisma leverages advancements in macrophage biology and engineering to improve therapeutic outcomes in oncology.

Aquinnah Pharmaceuticals, Inc. is a biotechnology company based in Cambridge, Massachusetts, that specializes in developing therapies for amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. Founded in 2014, the company is engaged in innovative research aimed at modulating neurodegenerative stress granules, which are believed to play a significant role in the pathology of ALS and similar conditions. By leveraging insights from brain pathology, Aquinnah aims to create treatments that can slow the progression of ALS, Alzheimer's disease, and other related disorders, thereby providing valuable options for healthcare professionals and patients battling these critical diseases.

ApoGen Biotechnologies, Inc. is focused on the development of new class of therapeutics targeting drivers of cancer genomic mutation.As the arsenal of available cancer therapies has grown and evolved from cytotoxic chemotherapy to targeted therapy to immunotherapy, one fact has unfortunately remained constant nearly all cancer drug therapies eventually fail due to the development of drug resistance. Mutation of cellular DNA is central to the formation of cancer, and chronic mutation of the cancer genome is a primary cause of cancer evolution and drug resistance, resulting in ineffective therapy, cancer recurrence and metastasis, and decreased overall survival.

Artios Pharma Limited is a biotechnology company based in Cambridge, United Kingdom, focused on developing innovative cancer treatments that target DNA damage response (DDR) pathways. Founded in 2015, the company aims to create first-in-class therapies that selectively kill cancer cells by exploiting the mechanisms involved in DNA repair. Its product pipeline features several promising candidates, including DNA polymerase theta (Polθ) and an in-licensed program targeting a novel DDR protein. Artios collaborates with Cancer Research Technology and leading researchers in the field to advance its development efforts. The company's leadership comprises experts with extensive experience in DDR drug discovery, and it has garnered investment from notable entities, including SV Life Sciences and AbbVie Ventures.

Morphic Therapeutic is a biotechnology company focused on developing oral small-molecule integrin therapeutics for various medical conditions, including autoimmune diseases, cardiovascular issues, metabolic disorders, fibrosis, and cancer. Its lead candidates in clinical development include MORF-720, an avß6 specific integrin inhibitor targeting idiopathic pulmonary fibrosis and primary sclerosing cholangitis, and MORF-057, an a4ß7 specific integrin inhibitor for inflammatory bowel disease. The company is also exploring additional integrin inhibitors for similar applications. Founded in 2015, Morphic Therapeutic has established collaborations with various organizations, including Engitix Ltd, Schrödinger, LLC, AbbVie Biotechnology Ltd, and Janssen Pharmaceuticals, to advance its research and development efforts. The company is headquartered in Waltham, Massachusetts, and leverages scientific discoveries made by its founder Tim Springer to innovate in the field of integrin therapies.

Stemcentrx is a biotechnology company focused on developing innovative therapies aimed at curing and significantly improving survival rates for cancer patients. Founded in 2008 by Brian Slingerland and Scott J. Dylla, the company is headquartered in South San Francisco, California. Stemcentrx specializes in disease-specific treatments designed to target tumors effectively at their roots. As of June 1, 2016, Stemcentrx operates as a subsidiary of AbbVie, further enhancing its capabilities in cancer research and treatment development.

Lodo Therapeutics Corporation is a drug discovery and development company dedicated to creating novel therapeutics derived from natural sources to address significant health challenges, particularly resistant infectious diseases and cancers. Founded to advance the scientific vision of Dr. Sean Brady from Rockefeller University, Lodo utilizes a genome-based, culture-independent platform to discover and characterize small molecules from microbial sources found in soil. By leveraging advancements in DNA sequencing and bioinformatics, the company aims to unlock the therapeutic potential of previously undiscovered molecules encoded in microbial DNA, with a focus on treating conditions that have high unmet medical needs. Lodo Therapeutics, supported by Accelerator Corporation, is headquartered in New York City, where its laboratory and offices are located within the Alexandria Center for Life Science.

Alector, Inc. is a clinical stage biopharmaceutical company focused on developing therapies for neurodegenerative diseases, including Alzheimer's and frontotemporal dementia. The company's lead product, AL001, is a humanized recombinant monoclonal antibody currently in phase II clinical trials for frontotemporal dementia. Additionally, AL101 is in phase I clinical trials for various neurodegenerative diseases, while AL002 and AL003 are undergoing phase 1b trials specifically for Alzheimer's disease. Alector is leveraging advancements in antibody technology, neuroimmunology, and human genetics to create innovative therapeutics. The company maintains a collaboration with Adimab, LLC, which aids in the discovery and optimization of antibody therapeutics. Alector has a pipeline of ten programs in the research and development stage and aims to advance several candidates through pre-clinical development within the next two years. Founded in 2013, Alector is headquartered in South San Francisco, California.

Petra Pharma Corporation, a pharmaceutical company, discovers and develops therapies that modulate phosphoinositide (PI) signaling pathways for the treatment of cancer and other serious diseases. It focuses on novel enzyme targets that play a central role in various important cellular processes, including cell division, growth, trafficking, and signaling. The company was incorporated in 2015 and is based in New York, New York.

Pharmacyclics LLC is a biopharmaceutical company headquartered in Sunnyvale, California, specializing in the development and commercialization of innovative small-molecule drugs aimed at treating cancer and immune-mediated diseases. The company is best known for IMBRUVICA, a groundbreaking oral therapy approved for several indications, including chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenström's macroglobulinemia. Pharmacyclics is actively advancing its pipeline, which includes various product candidates undergoing clinical trials for multiple cancers and conditions, such as the BTK inhibitor program and Abexinostat, an HDAC inhibitor. Additionally, the company has a collaboration with Janssen Biotech to further the development of IMBRUVICA and related compounds. Founded in 1991, Pharmacyclics has established itself as a key player in addressing significant unmet medical needs within oncology. As of 2015, it operates as a subsidiary of AbbVie Inc.

AM-Pharma B.V., a biopharmaceutical company, engages in the development and commercialization of therapeutics for human use in the Netherlands. It focuses in the pre-clinical and clinical development of novel therapeutics to treat inflammatory and infectious diseases. The company develops products based on endogenous proteins and protein derived peptides, as well as molecules that naturally occur in the human body. Its products include alkaline phosphatase for treatment of acute kidney injury and ulcerative colitis; and immune response amplifying peptide hLF1-11 for the treatment of drug resistant hospital acquired infections. The company was founded in 2000 and is headquartered in Bunnik, the Netherlands.

Virobay, Inc. operates as an anti-viral drug discovery and development company. It engages in developing, investigating, and creating treatments for hepatitis C, such as protease and polymerase inhibitors. The company was founded in 2006 and is headquartered in Menlo Park, California.

ImmuVenis is a biotechnology company with novel technology to discover and develop new biotherapeutics to treat infectious disease, cancer and autoimmune disorders

Exicure, Inc. is a clinical-stage biotechnology company focused on developing therapeutics for a range of conditions, including neurology, immuno-oncology, inflammatory diseases, and genetic disorders, utilizing its unique spherical nucleic acid (SNA) technology. The company's lead drug candidate, AST-008, is currently undergoing Phase 1b/2 clinical trials for advanced solid tumors. Additionally, Exicure is advancing XCUR-FXN, an SNA-based therapeutic in preclinical trials for Friedreich’s ataxia, and XCUR17, which targets messenger RNA associated with interleukin 17 receptor alpha. Exicure has established collaborations, including an agreement with Allergan Pharmaceuticals for developing SNA-based treatments for hair loss disorders and a partnership with DERMELIX, LLC for research and commercialization aimed at treating Netherton syndrome. Founded in 2011 and headquartered in Chicago, Illinois, Exicure is pioneering a new class of immunomodulatory and gene silencing drugs that enhance the delivery of nucleic acid therapeutics across various tissues.