Advanced Technology Ventures

Actifio, Inc. specializes in copy data virtualization solutions that streamline data management for enterprises. The company's flagship product, Actifio CDS, supports various applications and storage systems, making it suitable for large-scale deployments within diverse data center environments. Actifio also offers Actifio Sky, a platform designed for distributed enterprises, and Big Data Director, which aids in the protection and recovery of extensive file systems. Additionally, Actifio Resiliency Director provides automated recovery solutions, while OnVault focuses on long-term data retention for business intelligence and compliance. The company enables customers to manage their data more efficiently through its Virtual Data Pipeline™ technology, which decouples data from infrastructure, enhancing business agility and cloud access. With a presence in over 30 countries, Actifio serves numerous global enterprise customers and partners, facilitating a shift towards data-driven decision-making. Founded in 2009 and headquartered in Waltham, Massachusetts, Actifio has expanded its operations internationally, including locations in India, Australia, and Europe.

EndoGastric Solutions, Inc. is a medical device company specializing in innovative surgical technologies aimed at treating gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, the company develops and manufactures natural orifice surgical products. Its flagship technology, EsophyX, facilitates transoral reconstructive surgery, while the EsophyX Z device is specifically designed for the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions offers SerosaFuse Fasteners, a non-resorbable polypropylene product that provides strength comparable to traditional sutures. The company also supports surgeons through training courses and a range of consultative services, including pre-authorization and medical review.

Gynesonics, Inc. is a medical device company that focuses on designing and developing minimally invasive solutions for symptomatic uterine fibroids in women. Established in 2005 and headquartered in Redwood City, California, with an additional location in Beuningen, the Netherlands, the company offers the Sonata System, which utilizes sonography-guided transcervical fibroid ablation for the treatment of fibroids under intrauterine sonography guidance. Gynesonics aims to provide a safe and effective incisionless alternative to traditional surgical techniques such as hysterectomy and myomectomy, thereby enabling women to receive painless treatments for severe menstrual symptoms associated with fibroids.

Oasys Water, Inc. is a Boston-based company that specializes in forward osmosis technology aimed at reducing the cost of producing clean water. Founded in 2008, it has developed a platform called Engineered Osmosis, which incorporates forward osmosis and a draw solution recovery technique to make salt water treatment more economical. The company focuses on providing integrated membrane systems for high recovery desalination, brine management, and zero liquid discharge solutions. Through its innovative technologies, Oasys Water addresses the global water crisis by promoting more efficient and sustainable resource utilization, enabling industries to enhance their operational efficiencies while minimizing environmental impact. In addition to its Boston headquarters, Oasys Water also has an office in Dubai.

Cedexis Inc. specializes in internet performance control and monitoring solutions, focusing on optimizing web performance across various data centers, delivery networks, and clouds. Founded in 2009 by industry veterans Marty Kagan and Julien Coulon, the company offers a suite of products, including Cedexis Radar, a traffic management platform, and Cedexis Openmix, which routes traffic based on real-time performance data from multiple cloud providers. Cedexis Pulse enhances Openmix by allowing customers to define application-specific information, while the company's predictive load balancing solutions cater specifically to streaming video publishers. Cedexis aids companies in making informed vendor selections by providing comparative assessments of cloud performance and availability, thus enabling cost-effective trade-offs. With offices in Portland, San Francisco, Paris, London, and sales representation across several countries, Cedexis serves a global clientele, helping businesses ensure optimal online performance, fast page loads, and overall revenue growth through enhanced user experience. The company operates as a subsidiary of Citrix Systems.

EndoGastric Solutions, Inc. is a medical device company specializing in innovative surgical technologies aimed at treating gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, the company develops and manufactures natural orifice surgical products. Its flagship technology, EsophyX, facilitates transoral reconstructive surgery, while the EsophyX Z device is specifically designed for the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions offers SerosaFuse Fasteners, a non-resorbable polypropylene product that provides strength comparable to traditional sutures. The company also supports surgeons through training courses and a range of consultative services, including pre-authorization and medical review.

Gynesonics, Inc. is a medical device company that focuses on designing and developing minimally invasive solutions for symptomatic uterine fibroids in women. Established in 2005 and headquartered in Redwood City, California, with an additional location in Beuningen, the Netherlands, the company offers the Sonata System, which utilizes sonography-guided transcervical fibroid ablation for the treatment of fibroids under intrauterine sonography guidance. Gynesonics aims to provide a safe and effective incisionless alternative to traditional surgical techniques such as hysterectomy and myomectomy, thereby enabling women to receive painless treatments for severe menstrual symptoms associated with fibroids.

Thrasos is a bio-therapeutics company dedicated to discovering and developing targeted therapies for severe organ failure, with a primary emphasis on kidney diseases. The company's lead program, THR-184, aims to prevent and treat acute kidney injury (AKI). Additionally, Thrasos is advancing a preclinical development program that addresses chronic kidney disease (CKD). The company also focuses on developing innovative treatments for rare kidney-related conditions, such as myeloma cast nephropathy, which occurs when protein aggregates obstruct renal tubules, leading to the risk of permanent kidney damage. Through its efforts, Thrasos seeks to provide timely and effective treatment options for patients suffering from these serious kidney issues.

Planful, Inc. is a financial planning and analysis platform that provides cloud-based enterprise performance management software. Its solutions facilitate financial planning, consolidation, reporting, and analytics, with features that support cash flow forecasting, annual operating planning, workforce planning, and monthly financial closing. The platform aims to streamline processes, enhance collaboration, and improve workflow efficiency for organizations across various industries, including education, energy, food, insurance, life sciences, manufacturing, non-profit, retail, and transportation. Planful enables users to reduce manual efforts, accelerate cycle times, and enhance the accuracy of financial reporting. Founded in 2007 and headquartered in Redwood City, California, with additional offices in Scottsdale, Arizona, and Hyderabad, India, Planful was previously known as Host Analytics, Inc. The company serves over 1,000 clients globally, including well-known brands such as the Boston Red Sox and 23andMe.

Valeritas Holdings, Inc. was a medical technology company focused on developing and commercializing innovative solutions for the treatment of Type 2 diabetes. Founded in 2006 and headquartered in Bridgewater, New Jersey, the company offered the V-Go, a wearable insulin delivery device designed for basal-bolus therapy, allowing patients to manage their insulin intake conveniently and discreetly. Valeritas was also working on additional products, including the V-Go Prefill, aimed at simplifying the device-filling process, and V-Go SIM, which would facilitate real-time tracking of dosing utilization. The company marketed its products through third-party wholesalers and medical supply distributors, aiming to enhance the health and quality of life for individuals living with diabetes. However, on June 30, 2020, Valeritas Holdings filed for Chapter 11 bankruptcy, leading to its cessation of operations.

Gynesonics, Inc. is a medical device company that focuses on designing and developing minimally invasive solutions for symptomatic uterine fibroids in women. Established in 2005 and headquartered in Redwood City, California, with an additional location in Beuningen, the Netherlands, the company offers the Sonata System, which utilizes sonography-guided transcervical fibroid ablation for the treatment of fibroids under intrauterine sonography guidance. Gynesonics aims to provide a safe and effective incisionless alternative to traditional surgical techniques such as hysterectomy and myomectomy, thereby enabling women to receive painless treatments for severe menstrual symptoms associated with fibroids.

Evergage, Inc. is a technology company that specializes in a cloud-based real-time personalization platform aimed at enhancing customer engagement for digital marketers. Founded in 2010 and based in Somerville, Massachusetts, Evergage offers a suite of solutions that enable marketers to create individualized experiences for website visitors and mobile app users. Key offerings include the Evergage Platform, which allows for website personalization; Evergage Recommend, which provides tailored product and content recommendations; and Evergage Promote, which catalogs and promotes assets based on user behavior. The platform also includes tools for tracking shopping patterns, analyzing user history through engagement algorithms, and delivering customized experiences based on visitor data. Evergage serves various industries, including retail, financial services, technology, and hospitality, and has facilitated personalized interactions for over 2 billion web visitors across more than 150 organizations. The company has received multiple awards for its innovative approach to digital marketing.

EndoGastric Solutions, Inc. is a medical device company specializing in innovative surgical technologies aimed at treating gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, the company develops and manufactures natural orifice surgical products. Its flagship technology, EsophyX, facilitates transoral reconstructive surgery, while the EsophyX Z device is specifically designed for the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions offers SerosaFuse Fasteners, a non-resorbable polypropylene product that provides strength comparable to traditional sutures. The company also supports surgeons through training courses and a range of consultative services, including pre-authorization and medical review.

Nuvaira, Inc. is a medical device company focused on developing innovative treatments for obstructive lung diseases, particularly chronic obstructive pulmonary disease (COPD). The company has created a novel, catheter-based Lung Denervation System designed to address airway nerve hyperactivity, a common issue in patients with COPD and asthma. This minimally invasive procedure targets the parasympathetic nerves of the lungs, aiming to enhance lung function, improve exercise capacity, and elevate the quality of life for affected individuals. Founded in 2008 and headquartered in Minneapolis, Minnesota, Nuvaira was previously known as Holaira, Inc. before rebranding in June 2017.

Actifio, Inc. specializes in copy data virtualization solutions that streamline data management for enterprises. The company's flagship product, Actifio CDS, supports various applications and storage systems, making it suitable for large-scale deployments within diverse data center environments. Actifio also offers Actifio Sky, a platform designed for distributed enterprises, and Big Data Director, which aids in the protection and recovery of extensive file systems. Additionally, Actifio Resiliency Director provides automated recovery solutions, while OnVault focuses on long-term data retention for business intelligence and compliance. The company enables customers to manage their data more efficiently through its Virtual Data Pipeline™ technology, which decouples data from infrastructure, enhancing business agility and cloud access. With a presence in over 30 countries, Actifio serves numerous global enterprise customers and partners, facilitating a shift towards data-driven decision-making. Founded in 2009 and headquartered in Waltham, Massachusetts, Actifio has expanded its operations internationally, including locations in India, Australia, and Europe.

PowerVision, Inc. is a company that specializes in the development of innovative intraocular lenses aimed at restoring vision for individuals suffering from presbyopia and cataracts. Founded in 2002 and based in Belmont, California, PowerVision has created the FluidVision accommodating intraocular lens, which utilizes a unique fluid-controlled mechanism to mimic the natural function of a healthy eye. This technology allows users to dynamically adjust their focus for clear vision at all distances, potentially liberating millions from the need for glasses or other vision correction methods. The FluidVision lens is designed to meet the clinical and lifestyle needs of patients, offering a significant advancement in vision correction surgery. PowerVision's approach addresses the visual impairments faced by over 20 million people in the United States with cataracts and more than 90 million individuals affected by presbyopia, particularly those in their 40s and 50s.

Aquion Energy is a manufacturer of innovative energy storage solutions, specializing in sodium ion batteries designed for long-duration stationary energy storage. The company's proprietary Aqueous Hybrid Ion (AHI™) battery technology, developed from research by Carnegie Mellon University Professor Jay Whitacre, addresses the limitations of conventional energy storage systems. Aquion's batteries are safe, reliable, and environmentally friendly, utilizing non-toxic components such as saltwater, and they are free from heavy metals and toxic chemicals. These features make the AHI systems non-flammable and non-explosive, positioning them as a sustainable alternative for clients seeking to decrease reliance on fossil fuels. By optimizing existing grid-tied generation assets, Aquion Energy enhances the flexibility and efficiency of the electrical grid, facilitating the broader adoption of renewable energy technologies.

Aquion Energy is a manufacturer of innovative energy storage solutions, specializing in sodium ion batteries designed for long-duration stationary energy storage. The company's proprietary Aqueous Hybrid Ion (AHI™) battery technology, developed from research by Carnegie Mellon University Professor Jay Whitacre, addresses the limitations of conventional energy storage systems. Aquion's batteries are safe, reliable, and environmentally friendly, utilizing non-toxic components such as saltwater, and they are free from heavy metals and toxic chemicals. These features make the AHI systems non-flammable and non-explosive, positioning them as a sustainable alternative for clients seeking to decrease reliance on fossil fuels. By optimizing existing grid-tied generation assets, Aquion Energy enhances the flexibility and efficiency of the electrical grid, facilitating the broader adoption of renewable energy technologies.

Astria Therapeutics is a biopharmaceutical company based in Cambridge, Massachusetts, dedicated to developing innovative therapies for patients affected by rare allergic and immunological diseases. The company focuses on creating life-changing treatments, with its lead program, STAR-0215, being a monoclonal antibody designed to inhibit plasma kallikrein, currently in preclinical development for hereditary angioedema. Additionally, Astria is advancing STAR-0310, another monoclonal antibody, which targets the OX40 receptor and is also in preclinical development for atopic dermatitis, a condition characterized by impaired skin barrier function and significant itching. Through its targeted approach, Astria Therapeutics aims to address unmet medical needs in the field of immunology.

Calithera Biosciences is a clinical-stage biopharmaceutical company based in South San Francisco, California, dedicated to discovering and developing small molecule drugs targeting tumor metabolism and immunology for cancer treatment. The company's lead candidate, CB-839, is a glutaminase inhibitor currently in Phase II clinical trials aimed at treating solid tumors. Additionally, Calithera is advancing INCB001158, an oral arginase inhibitor in Phase I/II trials for hematology and oncology. Other notable projects include CB-280, intended for cystic fibrosis treatment, and CB-708, an inhibitor of CD73. The company has established collaborations, including a license agreement with Mars, Inc. for the development of arginase inhibitors and a clinical trial partnership with Bristol-Myers Squibb to evaluate nivolumab in combination with CB-839. Founded in 2010, Calithera is focused on building a pipeline of innovative cancer therapeutics that address critical pathways necessary for tumor growth and survival.

Fuze Digital Solutions, LLC is a provider of a cloud-based unified communications platform that enhances productivity and collaboration within enterprises. The platform, known as Fuze Suite, offers various features including business voice communications, video conferencing, and a suite of tools for customer care and engagement. These tools encompass a community knowledge base, case management, chat, feedback management, and online reporting, all designed to foster customer loyalty through effective communication. Founded in 2002 and originally known as ThinkingPhones, Fuze serves a diverse clientele, including organizations like Careerbuilder.com and Oregon Health & Sciences University. The company is headquartered in Boston, Massachusetts, with additional offices in major cities across North America and Europe, positioning itself as a key player in the unified communications market.

Coskata, Inc. is a renewable energy company focused on producing liquid fuels through advanced biological processes. The company utilizes proprietary microorganisms and innovative bioreactor designs to convert various feedstocks, including natural gas, wood, and waste materials, into ethanol. By developing technologies for processing bio-refuse and synthesizing gas, Coskata aims to provide a sustainable solution for fuel production that supports economic growth, environmental protection, and national security. Through its expertise in molecular biology and process engineering, the company enables the transformation of diverse resources into valuable fuels and chemicals.

Rive Technology is a clean energy company focused on advancing catalyst technology for petroleum refining. The company has developed a proprietary technology, originally conceived at MIT, that enhances traditional zeolite catalysts by introducing novel channels of medium pore size. This innovation allows large hydrocarbon molecules to be processed more efficiently, significantly increasing the yield of transportation fuels such as gasoline and diesel per barrel of crude oil. Rive's catalysts can be integrated seamlessly into existing refinery operations, enabling refiners to boost throughput and profitability with minimal capital investment. By improving product yields and process efficiency, Rive's technology supports the transition to more sustainable energy practices within the petroleum industry.

Solar Junction is a manufacturer of high efficiency III-V multi-junction solar cells based on ASLAM ™ materials. The company is dedicated to providing the industry’s highest efficiency solar cells to enable CPV as a cost effective energy solution. Founded in 2007, Solar Junction is headquartered in San Jose, California. Investors include New Enterprise Associates, Draper Fisher Jurvetson and Advanced Technology Ventures.

Planful, Inc. is a financial planning and analysis platform that provides cloud-based enterprise performance management software. Its solutions facilitate financial planning, consolidation, reporting, and analytics, with features that support cash flow forecasting, annual operating planning, workforce planning, and monthly financial closing. The platform aims to streamline processes, enhance collaboration, and improve workflow efficiency for organizations across various industries, including education, energy, food, insurance, life sciences, manufacturing, non-profit, retail, and transportation. Planful enables users to reduce manual efforts, accelerate cycle times, and enhance the accuracy of financial reporting. Founded in 2007 and headquartered in Redwood City, California, with additional offices in Scottsdale, Arizona, and Hyderabad, India, Planful was previously known as Host Analytics, Inc. The company serves over 1,000 clients globally, including well-known brands such as the Boston Red Sox and 23andMe.

Gynesonics, Inc. is a medical device company that focuses on designing and developing minimally invasive solutions for symptomatic uterine fibroids in women. Established in 2005 and headquartered in Redwood City, California, with an additional location in Beuningen, the Netherlands, the company offers the Sonata System, which utilizes sonography-guided transcervical fibroid ablation for the treatment of fibroids under intrauterine sonography guidance. Gynesonics aims to provide a safe and effective incisionless alternative to traditional surgical techniques such as hysterectomy and myomectomy, thereby enabling women to receive painless treatments for severe menstrual symptoms associated with fibroids.

Nuvaira, Inc. is a medical device company focused on developing innovative treatments for obstructive lung diseases, particularly chronic obstructive pulmonary disease (COPD). The company has created a novel, catheter-based Lung Denervation System designed to address airway nerve hyperactivity, a common issue in patients with COPD and asthma. This minimally invasive procedure targets the parasympathetic nerves of the lungs, aiming to enhance lung function, improve exercise capacity, and elevate the quality of life for affected individuals. Founded in 2008 and headquartered in Minneapolis, Minnesota, Nuvaira was previously known as Holaira, Inc. before rebranding in June 2017.

Astria Therapeutics is a biopharmaceutical company based in Cambridge, Massachusetts, dedicated to developing innovative therapies for patients affected by rare allergic and immunological diseases. The company focuses on creating life-changing treatments, with its lead program, STAR-0215, being a monoclonal antibody designed to inhibit plasma kallikrein, currently in preclinical development for hereditary angioedema. Additionally, Astria is advancing STAR-0310, another monoclonal antibody, which targets the OX40 receptor and is also in preclinical development for atopic dermatitis, a condition characterized by impaired skin barrier function and significant itching. Through its targeted approach, Astria Therapeutics aims to address unmet medical needs in the field of immunology.

Planful, Inc. is a financial planning and analysis platform that provides cloud-based enterprise performance management software. Its solutions facilitate financial planning, consolidation, reporting, and analytics, with features that support cash flow forecasting, annual operating planning, workforce planning, and monthly financial closing. The platform aims to streamline processes, enhance collaboration, and improve workflow efficiency for organizations across various industries, including education, energy, food, insurance, life sciences, manufacturing, non-profit, retail, and transportation. Planful enables users to reduce manual efforts, accelerate cycle times, and enhance the accuracy of financial reporting. Founded in 2007 and headquartered in Redwood City, California, with additional offices in Scottsdale, Arizona, and Hyderabad, India, Planful was previously known as Host Analytics, Inc. The company serves over 1,000 clients globally, including well-known brands such as the Boston Red Sox and 23andMe.

GluMetrics, Inc. is a medical device company based in Irvine, California, founded in 2005. It specializes in developing tools for clinicians to improve the care of critically ill patients. The company's primary product, GluCath, is an intravascular continuous glucose monitoring system designed to measure blood sugar levels in hospitalized patients. By providing real-time glucose data, GluMetrics aims to enhance patient management and outcomes in critical care settings.

Calithera Biosciences is a clinical-stage biopharmaceutical company based in South San Francisco, California, dedicated to discovering and developing small molecule drugs targeting tumor metabolism and immunology for cancer treatment. The company's lead candidate, CB-839, is a glutaminase inhibitor currently in Phase II clinical trials aimed at treating solid tumors. Additionally, Calithera is advancing INCB001158, an oral arginase inhibitor in Phase I/II trials for hematology and oncology. Other notable projects include CB-280, intended for cystic fibrosis treatment, and CB-708, an inhibitor of CD73. The company has established collaborations, including a license agreement with Mars, Inc. for the development of arginase inhibitors and a clinical trial partnership with Bristol-Myers Squibb to evaluate nivolumab in combination with CB-839. Founded in 2010, Calithera is focused on building a pipeline of innovative cancer therapeutics that address critical pathways necessary for tumor growth and survival.

Modria, Inc. is a developer of a cloud-based online dispute resolution platform that automates the resolution of customer disputes related to eCommerce. Founded in 2011 and headquartered in San Jose, California, with an additional office in Chennai, India, the company serves a diverse clientele, including tangible goods and service marketplaces, payment networks, medium and large online merchants, government agencies, and classified sites. The platform seamlessly integrates with both the back-end architecture and front-end user experience of eCommerce sites, enabling businesses to efficiently resolve customer issues without the need for human intervention. As of May 30, 2017, Modria operates as a subsidiary of Tyler Technologies, Inc.

Thrasos is a bio-therapeutics company dedicated to discovering and developing targeted therapies for severe organ failure, with a primary emphasis on kidney diseases. The company's lead program, THR-184, aims to prevent and treat acute kidney injury (AKI). Additionally, Thrasos is advancing a preclinical development program that addresses chronic kidney disease (CKD). The company also focuses on developing innovative treatments for rare kidney-related conditions, such as myeloma cast nephropathy, which occurs when protein aggregates obstruct renal tubules, leading to the risk of permanent kidney damage. Through its efforts, Thrasos seeks to provide timely and effective treatment options for patients suffering from these serious kidney issues.

Fuze Digital Solutions, LLC is a provider of a cloud-based unified communications platform that enhances productivity and collaboration within enterprises. The platform, known as Fuze Suite, offers various features including business voice communications, video conferencing, and a suite of tools for customer care and engagement. These tools encompass a community knowledge base, case management, chat, feedback management, and online reporting, all designed to foster customer loyalty through effective communication. Founded in 2002 and originally known as ThinkingPhones, Fuze serves a diverse clientele, including organizations like Careerbuilder.com and Oregon Health & Sciences University. The company is headquartered in Boston, Massachusetts, with additional offices in major cities across North America and Europe, positioning itself as a key player in the unified communications market.

Nuvaira, Inc. is a medical device company focused on developing innovative treatments for obstructive lung diseases, particularly chronic obstructive pulmonary disease (COPD). The company has created a novel, catheter-based Lung Denervation System designed to address airway nerve hyperactivity, a common issue in patients with COPD and asthma. This minimally invasive procedure targets the parasympathetic nerves of the lungs, aiming to enhance lung function, improve exercise capacity, and elevate the quality of life for affected individuals. Founded in 2008 and headquartered in Minneapolis, Minnesota, Nuvaira was previously known as Holaira, Inc. before rebranding in June 2017.

QuickPay was founded in 2010 with a vision to leverage trends in mobile technology to remove the pain and hassle of finding, accessing, and paying for parking and transportation. Their revolutionary QP QuickPay mobile parking platform offers users one mobile parking application that works across all parking environments — drivers can even raise parking gates using their mobile phones — and gives parking owners and operators an efficient way to enable mobile parking across all their assets with a single integrated solution. Today drivers can use QP QuickPay and a mobile phone to find and pay for parking at hundreds of locations across the U.S., with new locations being added continually.

EndoGastric Solutions, Inc. is a medical device company specializing in innovative surgical technologies aimed at treating gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, the company develops and manufactures natural orifice surgical products. Its flagship technology, EsophyX, facilitates transoral reconstructive surgery, while the EsophyX Z device is specifically designed for the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions offers SerosaFuse Fasteners, a non-resorbable polypropylene product that provides strength comparable to traditional sutures. The company also supports surgeons through training courses and a range of consultative services, including pre-authorization and medical review.

Evergage, Inc. is a technology company that specializes in a cloud-based real-time personalization platform aimed at enhancing customer engagement for digital marketers. Founded in 2010 and based in Somerville, Massachusetts, Evergage offers a suite of solutions that enable marketers to create individualized experiences for website visitors and mobile app users. Key offerings include the Evergage Platform, which allows for website personalization; Evergage Recommend, which provides tailored product and content recommendations; and Evergage Promote, which catalogs and promotes assets based on user behavior. The platform also includes tools for tracking shopping patterns, analyzing user history through engagement algorithms, and delivering customized experiences based on visitor data. Evergage serves various industries, including retail, financial services, technology, and hospitality, and has facilitated personalized interactions for over 2 billion web visitors across more than 150 organizations. The company has received multiple awards for its innovative approach to digital marketing.

EndPlay is a prominent provider of cloud-based content management, engagement, and monetization solutions. Utilizing its innovative 'Intelligent Rendering' technology, the company offers a comprehensive platform that enables clients to efficiently produce, manage, and deliver content optimized for various devices. EndPlay serves enterprise clients across multiple sectors, including media, entertainment, consumer packaged goods, and education, providing support through a dedicated Client Services team. The company emphasizes a customer-centric approach, promoting innovation to help clients enhance audience engagement and maintain a competitive edge. Additionally, EndPlay offers training courses, support services, and analytics to improve platform productivity. Headquartered in Los Angeles, California, EndPlay also has regional offices in Florida and New Jersey and is expanding its presence in Europe and Asia.

EndoGastric Solutions, Inc. is a medical device company specializing in innovative surgical technologies aimed at treating gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, the company develops and manufactures natural orifice surgical products. Its flagship technology, EsophyX, facilitates transoral reconstructive surgery, while the EsophyX Z device is specifically designed for the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions offers SerosaFuse Fasteners, a non-resorbable polypropylene product that provides strength comparable to traditional sutures. The company also supports surgeons through training courses and a range of consultative services, including pre-authorization and medical review.

EndoGastric Solutions, Inc. is a medical device company specializing in innovative surgical technologies aimed at treating gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, the company develops and manufactures natural orifice surgical products. Its flagship technology, EsophyX, facilitates transoral reconstructive surgery, while the EsophyX Z device is specifically designed for the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions offers SerosaFuse Fasteners, a non-resorbable polypropylene product that provides strength comparable to traditional sutures. The company also supports surgeons through training courses and a range of consultative services, including pre-authorization and medical review.

GluMetrics, Inc. is a medical device company based in Irvine, California, founded in 2005. It specializes in developing tools for clinicians to improve the care of critically ill patients. The company's primary product, GluCath, is an intravascular continuous glucose monitoring system designed to measure blood sugar levels in hospitalized patients. By providing real-time glucose data, GluMetrics aims to enhance patient management and outcomes in critical care settings.

Solar Junction is a manufacturer of high efficiency III-V multi-junction solar cells based on ASLAM ™ materials. The company is dedicated to providing the industry’s highest efficiency solar cells to enable CPV as a cost effective energy solution. Founded in 2007, Solar Junction is headquartered in San Jose, California. Investors include New Enterprise Associates, Draper Fisher Jurvetson and Advanced Technology Ventures.

Astria Therapeutics is a biopharmaceutical company based in Cambridge, Massachusetts, dedicated to developing innovative therapies for patients affected by rare allergic and immunological diseases. The company focuses on creating life-changing treatments, with its lead program, STAR-0215, being a monoclonal antibody designed to inhibit plasma kallikrein, currently in preclinical development for hereditary angioedema. Additionally, Astria is advancing STAR-0310, another monoclonal antibody, which targets the OX40 receptor and is also in preclinical development for atopic dermatitis, a condition characterized by impaired skin barrier function and significant itching. Through its targeted approach, Astria Therapeutics aims to address unmet medical needs in the field of immunology.

Actifio, Inc. specializes in copy data virtualization solutions that streamline data management for enterprises. The company's flagship product, Actifio CDS, supports various applications and storage systems, making it suitable for large-scale deployments within diverse data center environments. Actifio also offers Actifio Sky, a platform designed for distributed enterprises, and Big Data Director, which aids in the protection and recovery of extensive file systems. Additionally, Actifio Resiliency Director provides automated recovery solutions, while OnVault focuses on long-term data retention for business intelligence and compliance. The company enables customers to manage their data more efficiently through its Virtual Data Pipeline™ technology, which decouples data from infrastructure, enhancing business agility and cloud access. With a presence in over 30 countries, Actifio serves numerous global enterprise customers and partners, facilitating a shift towards data-driven decision-making. Founded in 2009 and headquartered in Waltham, Massachusetts, Actifio has expanded its operations internationally, including locations in India, Australia, and Europe.

Calithera Biosciences is a clinical-stage biopharmaceutical company based in South San Francisco, California, dedicated to discovering and developing small molecule drugs targeting tumor metabolism and immunology for cancer treatment. The company's lead candidate, CB-839, is a glutaminase inhibitor currently in Phase II clinical trials aimed at treating solid tumors. Additionally, Calithera is advancing INCB001158, an oral arginase inhibitor in Phase I/II trials for hematology and oncology. Other notable projects include CB-280, intended for cystic fibrosis treatment, and CB-708, an inhibitor of CD73. The company has established collaborations, including a license agreement with Mars, Inc. for the development of arginase inhibitors and a clinical trial partnership with Bristol-Myers Squibb to evaluate nivolumab in combination with CB-839. Founded in 2010, Calithera is focused on building a pipeline of innovative cancer therapeutics that address critical pathways necessary for tumor growth and survival.

Valeritas Holdings, Inc. was a medical technology company focused on developing and commercializing innovative solutions for the treatment of Type 2 diabetes. Founded in 2006 and headquartered in Bridgewater, New Jersey, the company offered the V-Go, a wearable insulin delivery device designed for basal-bolus therapy, allowing patients to manage their insulin intake conveniently and discreetly. Valeritas was also working on additional products, including the V-Go Prefill, aimed at simplifying the device-filling process, and V-Go SIM, which would facilitate real-time tracking of dosing utilization. The company marketed its products through third-party wholesalers and medical supply distributors, aiming to enhance the health and quality of life for individuals living with diabetes. However, on June 30, 2020, Valeritas Holdings filed for Chapter 11 bankruptcy, leading to its cessation of operations.

Aquion Energy is a manufacturer of innovative energy storage solutions, specializing in sodium ion batteries designed for long-duration stationary energy storage. The company's proprietary Aqueous Hybrid Ion (AHI™) battery technology, developed from research by Carnegie Mellon University Professor Jay Whitacre, addresses the limitations of conventional energy storage systems. Aquion's batteries are safe, reliable, and environmentally friendly, utilizing non-toxic components such as saltwater, and they are free from heavy metals and toxic chemicals. These features make the AHI systems non-flammable and non-explosive, positioning them as a sustainable alternative for clients seeking to decrease reliance on fossil fuels. By optimizing existing grid-tied generation assets, Aquion Energy enhances the flexibility and efficiency of the electrical grid, facilitating the broader adoption of renewable energy technologies.

Cedexis Inc. specializes in internet performance control and monitoring solutions, focusing on optimizing web performance across various data centers, delivery networks, and clouds. Founded in 2009 by industry veterans Marty Kagan and Julien Coulon, the company offers a suite of products, including Cedexis Radar, a traffic management platform, and Cedexis Openmix, which routes traffic based on real-time performance data from multiple cloud providers. Cedexis Pulse enhances Openmix by allowing customers to define application-specific information, while the company's predictive load balancing solutions cater specifically to streaming video publishers. Cedexis aids companies in making informed vendor selections by providing comparative assessments of cloud performance and availability, thus enabling cost-effective trade-offs. With offices in Portland, San Francisco, Paris, London, and sales representation across several countries, Cedexis serves a global clientele, helping businesses ensure optimal online performance, fast page loads, and overall revenue growth through enhanced user experience. The company operates as a subsidiary of Citrix Systems.

PowerVision, Inc. is a company that specializes in the development of innovative intraocular lenses aimed at restoring vision for individuals suffering from presbyopia and cataracts. Founded in 2002 and based in Belmont, California, PowerVision has created the FluidVision accommodating intraocular lens, which utilizes a unique fluid-controlled mechanism to mimic the natural function of a healthy eye. This technology allows users to dynamically adjust their focus for clear vision at all distances, potentially liberating millions from the need for glasses or other vision correction methods. The FluidVision lens is designed to meet the clinical and lifestyle needs of patients, offering a significant advancement in vision correction surgery. PowerVision's approach addresses the visual impairments faced by over 20 million people in the United States with cataracts and more than 90 million individuals affected by presbyopia, particularly those in their 40s and 50s.

Verastem, Inc. is a biopharmaceutical company dedicated to developing and commercializing innovative treatments aimed at improving the survival and quality of life for cancer patients. Based in Needham, Massachusetts, Verastem markets COPIKTRA (duvelisib), an oral medication indicated for adult patients with relapsed or refractory chronic lymphocytic leukemia and follicular lymphoma after multiple prior therapies. In addition to this approved therapy, the company is advancing its pipeline with the focal adhesion kinase inhibitor defactinib, which is being studied in combination with immunotherapies for various cancers, including pancreatic and ovarian cancers, as well as non-small cell lung cancer. Verastem's research emphasizes inhibiting critical signaling pathways that promote cancer cell survival and tumor growth, particularly those associated with the RAS/MAPK pathway. The company has formed collaborative agreements with Yakult Honsha Co., Ltd. and CSPC Pharmaceutical Group Limited to enhance its development efforts. Founded in 2010, Verastem continues to focus on late-stage development of its anticancer agents.

Evergage, Inc. is a technology company that specializes in a cloud-based real-time personalization platform aimed at enhancing customer engagement for digital marketers. Founded in 2010 and based in Somerville, Massachusetts, Evergage offers a suite of solutions that enable marketers to create individualized experiences for website visitors and mobile app users. Key offerings include the Evergage Platform, which allows for website personalization; Evergage Recommend, which provides tailored product and content recommendations; and Evergage Promote, which catalogs and promotes assets based on user behavior. The platform also includes tools for tracking shopping patterns, analyzing user history through engagement algorithms, and delivering customized experiences based on visitor data. Evergage serves various industries, including retail, financial services, technology, and hospitality, and has facilitated personalized interactions for over 2 billion web visitors across more than 150 organizations. The company has received multiple awards for its innovative approach to digital marketing.

PolyRemedy offers integrated wound management systems designed to increase consistency by extending wound care expertise to the point of care. The PolyRemedy Personalized Woundcare System (PWS) enables clinicians to document care through easy-to-use, web-based assessment tools and order personalized wound dressings, while also providing critical and unprecedented visibility into wound care data. It was founded in 2004 and is headquartered in Concord, Massachusetts.

[x+1] is a recognized leader in marketing technology, specifically noted for its advanced capabilities in both data management and demand-side platform services. The company offers the Origin Platform, a comprehensive programmatic marketing hub that enables brands to engage effectively with their audiences through various digital channels. Utilizing its Origin Data Management Platform, which combines first and third-party data with a Predictive Optimization Engine, [x+1] facilitates targeted audience engagement across online display, mobile, email, and other digital mediums. This capability has made [x+1] a trusted partner for many top brands, particularly in the financial services sector. Headquartered in New York City, [x+1] also has offices in Connecticut, Illinois, Michigan, and California.

Rive Technology is a clean energy company focused on advancing catalyst technology for petroleum refining. The company has developed a proprietary technology, originally conceived at MIT, that enhances traditional zeolite catalysts by introducing novel channels of medium pore size. This innovation allows large hydrocarbon molecules to be processed more efficiently, significantly increasing the yield of transportation fuels such as gasoline and diesel per barrel of crude oil. Rive's catalysts can be integrated seamlessly into existing refinery operations, enabling refiners to boost throughput and profitability with minimal capital investment. By improving product yields and process efficiency, Rive's technology supports the transition to more sustainable energy practices within the petroleum industry.

Astria Therapeutics is a biopharmaceutical company based in Cambridge, Massachusetts, dedicated to developing innovative therapies for patients affected by rare allergic and immunological diseases. The company focuses on creating life-changing treatments, with its lead program, STAR-0215, being a monoclonal antibody designed to inhibit plasma kallikrein, currently in preclinical development for hereditary angioedema. Additionally, Astria is advancing STAR-0310, another monoclonal antibody, which targets the OX40 receptor and is also in preclinical development for atopic dermatitis, a condition characterized by impaired skin barrier function and significant itching. Through its targeted approach, Astria Therapeutics aims to address unmet medical needs in the field of immunology.

Actifio, Inc. specializes in copy data virtualization solutions that streamline data management for enterprises. The company's flagship product, Actifio CDS, supports various applications and storage systems, making it suitable for large-scale deployments within diverse data center environments. Actifio also offers Actifio Sky, a platform designed for distributed enterprises, and Big Data Director, which aids in the protection and recovery of extensive file systems. Additionally, Actifio Resiliency Director provides automated recovery solutions, while OnVault focuses on long-term data retention for business intelligence and compliance. The company enables customers to manage their data more efficiently through its Virtual Data Pipeline™ technology, which decouples data from infrastructure, enhancing business agility and cloud access. With a presence in over 30 countries, Actifio serves numerous global enterprise customers and partners, facilitating a shift towards data-driven decision-making. Founded in 2009 and headquartered in Waltham, Massachusetts, Actifio has expanded its operations internationally, including locations in India, Australia, and Europe.

Qumu Corporation specializes in providing comprehensive tools for enterprises to create, manage, secure, distribute, and measure live and on-demand video content. The company offers an end-to-end solution that includes software licenses, server appliances, software-enabled devices, and a cloud-hosted software-as-a-service platform. In addition to these products, Qumu provides maintenance, support, and professional services. Its solutions cater to a variety of sectors, including banking, finance, insurance, manufacturing, telecom, technology, and healthcare, as well as government entities, through both direct sales and partnerships. Founded in 1978 and headquartered in Minneapolis, Minnesota, Qumu was formerly known as Rimage Corporation before rebranding in 2013. The majority of the company's revenue is generated from North America, with additional markets in Europe and Asia.

EndoGastric Solutions, Inc. is a medical device company specializing in innovative surgical technologies aimed at treating gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, the company develops and manufactures natural orifice surgical products. Its flagship technology, EsophyX, facilitates transoral reconstructive surgery, while the EsophyX Z device is specifically designed for the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions offers SerosaFuse Fasteners, a non-resorbable polypropylene product that provides strength comparable to traditional sutures. The company also supports surgeons through training courses and a range of consultative services, including pre-authorization and medical review.

NeuroVista Corporation is a medical device company based in Seattle, Washington, focused on developing innovative technologies for the management and treatment of epilepsy, a condition impacting approximately 3 million individuals in the United States. The company provides advisory technologies designed to reduce the uncertainty surrounding the onset of epileptic seizures, which can vary in severity from brief lapses of awareness to severe convulsions. Founded in 2002 and originally known as BioNeuronics Corporation, NeuroVista rebranded in 2007 to emphasize its commitment to addressing the challenges faced by those affected by epilepsy, a neurological disorder that predominantly affects individuals aged 15 to 64.

Calxeda provides revolutionary efficiency to the data center. Leveraging ultra-low power technology from ARM, servers built on Calxeda’s silicon and software platform consume a fraction of the power and space of today’s best-in-class servers, enabling data centers to realize significant reduction in capital and operating expenses. The Calxeda platform scales efficiently to thousands of server nodes, with unique network and storage acceleration, and is enhanced with management technology to deliver true “energy-proportional” computing. The result is a stunning breakthrough in performance efficiency, density, and scalability.

Coskata, Inc. is a renewable energy company focused on producing liquid fuels through advanced biological processes. The company utilizes proprietary microorganisms and innovative bioreactor designs to convert various feedstocks, including natural gas, wood, and waste materials, into ethanol. By developing technologies for processing bio-refuse and synthesizing gas, Coskata aims to provide a sustainable solution for fuel production that supports economic growth, environmental protection, and national security. Through its expertise in molecular biology and process engineering, the company enables the transformation of diverse resources into valuable fuels and chemicals.

Calithera Biosciences is a clinical-stage biopharmaceutical company based in South San Francisco, California, dedicated to discovering and developing small molecule drugs targeting tumor metabolism and immunology for cancer treatment. The company's lead candidate, CB-839, is a glutaminase inhibitor currently in Phase II clinical trials aimed at treating solid tumors. Additionally, Calithera is advancing INCB001158, an oral arginase inhibitor in Phase I/II trials for hematology and oncology. Other notable projects include CB-280, intended for cystic fibrosis treatment, and CB-708, an inhibitor of CD73. The company has established collaborations, including a license agreement with Mars, Inc. for the development of arginase inhibitors and a clinical trial partnership with Bristol-Myers Squibb to evaluate nivolumab in combination with CB-839. Founded in 2010, Calithera is focused on building a pipeline of innovative cancer therapeutics that address critical pathways necessary for tumor growth and survival.

Acceleron Pharma Inc. is a biopharmaceutical company dedicated to the discovery, development, and commercialization of therapeutics aimed at treating serious and rare diseases. Based in Cambridge, Massachusetts, the company focuses on developing novel biotherapeutics that modulate growth factors related to bone, muscle, fat, and vascular health. Its product portfolio includes luspatercept-aamt, marketed as REBLOZYL, for treating anemia in adult patients with beta-thalassemia, and candidates such as Sotatercept for pulmonary arterial hypertension. Additionally, Acceleron is advancing ACE-083, a neuromuscular treatment currently in Phase II trials for Charcot-Marie-Tooth disease. The company collaborates with partners like Celgene Corporation and Fulcrum Therapeutics to develop therapies targeting specific pathways in pulmonary diseases. Founded in 2003, Acceleron Pharma continues to focus on creating innovative treatments for conditions such as cancer-related bone loss, muscle degeneration, and metabolic disorders.

Planful, Inc. is a financial planning and analysis platform that provides cloud-based enterprise performance management software. Its solutions facilitate financial planning, consolidation, reporting, and analytics, with features that support cash flow forecasting, annual operating planning, workforce planning, and monthly financial closing. The platform aims to streamline processes, enhance collaboration, and improve workflow efficiency for organizations across various industries, including education, energy, food, insurance, life sciences, manufacturing, non-profit, retail, and transportation. Planful enables users to reduce manual efforts, accelerate cycle times, and enhance the accuracy of financial reporting. Founded in 2007 and headquartered in Redwood City, California, with additional offices in Scottsdale, Arizona, and Hyderabad, India, Planful was previously known as Host Analytics, Inc. The company serves over 1,000 clients globally, including well-known brands such as the Boston Red Sox and 23andMe.

Zeltiq Aesthetics, founded in 2005 and headquartered in Pleasanton, California, is a medical technology company focused on developing non-invasive solutions for the reduction of unwanted fat tissue. The company's flagship product, the CoolSculpting system, employs a patented technology known as Cryolipolysis, which utilizes controlled cooling to selectively target and eliminate fat cells while preserving surrounding skin and tissue. This FDA-cleared treatment provides a non-surgical option for individuals seeking to reduce stubborn fat bulges. Zeltiq distributes its products through a direct sales force and a network of distributors, catering primarily to dermatologists, plastic surgeons, and aesthetic specialists across North America, Europe, the Asia-Pacific, and Latin America. The company was previously known as Juniper Medical, Inc. before rebranding in 2007. As of 2017, Zeltiq operates as a subsidiary of Allergan plc.

Altura Medical, Inc. is a medical device company based in Menlo Park, California, focused on developing advanced endograft technology for the treatment of abdominal aortic aneurysms (AAA) and related conditions. The company's primary product is the Agili-D AAA System, an innovative endovascular aneurysm repair technology designed to improve patient outcomes. Founded in 2008, Altura Medical has garnered support from a notable group of venture capital investors and is led by a seasoned management team. The company operates as a subsidiary of Lombard Medical, Inc. as of July 2015.

Astria Therapeutics is a biopharmaceutical company based in Cambridge, Massachusetts, dedicated to developing innovative therapies for patients affected by rare allergic and immunological diseases. The company focuses on creating life-changing treatments, with its lead program, STAR-0215, being a monoclonal antibody designed to inhibit plasma kallikrein, currently in preclinical development for hereditary angioedema. Additionally, Astria is advancing STAR-0310, another monoclonal antibody, which targets the OX40 receptor and is also in preclinical development for atopic dermatitis, a condition characterized by impaired skin barrier function and significant itching. Through its targeted approach, Astria Therapeutics aims to address unmet medical needs in the field of immunology.

Solar Junction is a manufacturer of high efficiency III-V multi-junction solar cells based on ASLAM ™ materials. The company is dedicated to providing the industry’s highest efficiency solar cells to enable CPV as a cost effective energy solution. Founded in 2007, Solar Junction is headquartered in San Jose, California. Investors include New Enterprise Associates, Draper Fisher Jurvetson and Advanced Technology Ventures.

EndoGastric Solutions, Inc. is a medical device company specializing in innovative surgical technologies aimed at treating gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, the company develops and manufactures natural orifice surgical products. Its flagship technology, EsophyX, facilitates transoral reconstructive surgery, while the EsophyX Z device is specifically designed for the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions offers SerosaFuse Fasteners, a non-resorbable polypropylene product that provides strength comparable to traditional sutures. The company also supports surgeons through training courses and a range of consultative services, including pre-authorization and medical review.

EndoGastric Solutions, Inc. is a medical device company specializing in innovative surgical technologies aimed at treating gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, the company develops and manufactures natural orifice surgical products. Its flagship technology, EsophyX, facilitates transoral reconstructive surgery, while the EsophyX Z device is specifically designed for the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions offers SerosaFuse Fasteners, a non-resorbable polypropylene product that provides strength comparable to traditional sutures. The company also supports surgeons through training courses and a range of consultative services, including pre-authorization and medical review.

EndoGastric Solutions, Inc. is a medical device company specializing in innovative surgical technologies aimed at treating gastrointestinal diseases, particularly gastroesophageal reflux disease (GERD). Founded in 2002 and headquartered in Redmond, Washington, with an additional office in San Mateo, California, the company develops and manufactures natural orifice surgical products. Its flagship technology, EsophyX, facilitates transoral reconstructive surgery, while the EsophyX Z device is specifically designed for the transoral incisionless fundoplication procedure. Additionally, EndoGastric Solutions offers SerosaFuse Fasteners, a non-resorbable polypropylene product that provides strength comparable to traditional sutures. The company also supports surgeons through training courses and a range of consultative services, including pre-authorization and medical review.

Silicor Materials, Inc. specializes in the production of solar silicon for photovoltaic cell and module manufacturers globally. Established in 2006 and headquartered in San Jose, California, the company operates manufacturing facilities in Vaughan, Canada, and Mississippi, along with a research and development center in Berlin, Germany. Silicor Materials offers high-quality, low-cost solar silicon, which serves as an alternative to more expensive electronic-grade silicon, thereby enabling photovoltaic module manufacturers to lower their production costs while adhering to demanding performance standards. In addition to solar silicon, the company produces aluminum by-products, including aluminum-silicon master alloys and polyaluminum chloride, which are utilized in municipal and industrial water treatment applications.

Planful, Inc. is a financial planning and analysis platform that provides cloud-based enterprise performance management software. Its solutions facilitate financial planning, consolidation, reporting, and analytics, with features that support cash flow forecasting, annual operating planning, workforce planning, and monthly financial closing. The platform aims to streamline processes, enhance collaboration, and improve workflow efficiency for organizations across various industries, including education, energy, food, insurance, life sciences, manufacturing, non-profit, retail, and transportation. Planful enables users to reduce manual efforts, accelerate cycle times, and enhance the accuracy of financial reporting. Founded in 2007 and headquartered in Redwood City, California, with additional offices in Scottsdale, Arizona, and Hyderabad, India, Planful was previously known as Host Analytics, Inc. The company serves over 1,000 clients globally, including well-known brands such as the Boston Red Sox and 23andMe.

Nuventix, based in Austin, Texas, specializes in active thermal management solutions, particularly through its patented SynJet module. This innovative synthetic jet cooling technology generates turbulent pulses of air using an electromagnetic actuator to effectively manage heat removal. Initially successful in computer cooling applications, Nuventix has made significant strides in the LED cooling market, advancing it by two years ahead of industry analysts' estimates. This progress not only enhances cooling efficiency but also supports the development of general illumination designs that leverage the benefits of LED technology.

Ardian, established in 1996, is a France-based asset manager offering global investment management services. It primarily focuses on fund of funds (55.21%), followed by direct funds (19.79%), infrastructure (16.67%), and private debt (7.29%), with a minor allocation to real estate (1.04%). Ardian invests across various sectors, including food value chain, healthcare, technology, and industrials, with a presence in Europe and North America.

GI Dynamics, Inc. is a medical device company that focuses on developing non-surgical therapies for the treatment of type 2 diabetes and obesity. The company's flagship product, EndoBarrier, is designed to help patients manage these conditions effectively. Founded in 2003, GI Dynamics is headquartered in Boston, Massachusetts, and markets its products primarily in Europe, the Middle East, the Asia Pacific, and South America. The company serves healthcare providers and third-party distributors, aiming to provide innovative solutions for metabolic diseases.

Oasys Water, Inc. is a Boston-based company that specializes in forward osmosis technology aimed at reducing the cost of producing clean water. Founded in 2008, it has developed a platform called Engineered Osmosis, which incorporates forward osmosis and a draw solution recovery technique to make salt water treatment more economical. The company focuses on providing integrated membrane systems for high recovery desalination, brine management, and zero liquid discharge solutions. Through its innovative technologies, Oasys Water addresses the global water crisis by promoting more efficient and sustainable resource utilization, enabling industries to enhance their operational efficiencies while minimizing environmental impact. In addition to its Boston headquarters, Oasys Water also has an office in Dubai.

Hydra Biosciences is a biopharmaceutical company located in Cambridge, Massachusetts, focused on developing innovative drugs for pain, inflammation, cardiovascular diseases, and other conditions. The company utilizes its expertise in novel ion channels, specifically targeting Transient Receptor Potential (TRP) ion channels, to create selective and safer therapeutic options. Hydra employs proprietary high-throughput screening platforms that facilitate the identification and development of drug candidates aimed at addressing significant unmet medical needs. With a strong intellectual property portfolio and a flexible approach to drug discovery, Hydra differentiates itself from traditional biopharmaceutical firms. The company has attracted substantial financing from notable investors, enabling it to advance its drug development programs effectively.

CombineNet, Inc. is an advanced sourcing technology company that has been delivering value to mid-sized and global organizations for over a decade. The company specializes in sourcing and optimization technologies tailored for supply-chain-based organizations across various industries. Its flagship product, CombineNet ASAP (Advanced Sourcing Application Platform), is a web-based software-as-a-service solution that enables sourcing teams to efficiently create, launch, and manage sourcing events of any complexity. This platform focuses on strategically sourcing complex spend categories and enhancing sourcing-award decisions through optimization, thereby streamlining the supplier and spend decision-making process.

Coskata, Inc. is a renewable energy company focused on producing liquid fuels through advanced biological processes. The company utilizes proprietary microorganisms and innovative bioreactor designs to convert various feedstocks, including natural gas, wood, and waste materials, into ethanol. By developing technologies for processing bio-refuse and synthesizing gas, Coskata aims to provide a sustainable solution for fuel production that supports economic growth, environmental protection, and national security. Through its expertise in molecular biology and process engineering, the company enables the transformation of diverse resources into valuable fuels and chemicals.

Silicor Materials, Inc. specializes in the production of solar silicon for photovoltaic cell and module manufacturers globally. Established in 2006 and headquartered in San Jose, California, the company operates manufacturing facilities in Vaughan, Canada, and Mississippi, along with a research and development center in Berlin, Germany. Silicor Materials offers high-quality, low-cost solar silicon, which serves as an alternative to more expensive electronic-grade silicon, thereby enabling photovoltaic module manufacturers to lower their production costs while adhering to demanding performance standards. In addition to solar silicon, the company produces aluminum by-products, including aluminum-silicon master alloys and polyaluminum chloride, which are utilized in municipal and industrial water treatment applications.

Anagran specializes in flow-based traffic management products designed to mitigate the adverse effects of network congestion, thereby facilitating the seamless scaling of video, voice, data, and wireless traffic across converged IP networks. The company's solutions protect essential network traffic by managing end-to-end flows based on their behavior, ensuring optimal quality and performance levels without relying on invasive deep packet inspection techniques. This approach allows service providers and enterprises to consistently achieve high-performance standards while significantly lowering both capital expenditures and ongoing network costs. Founded by Dr. Larry Roberts, a recognized pioneer of the Internet, Anagran is committed to enhancing network efficiency and reliability.

Valeritas Holdings, Inc. was a medical technology company focused on developing and commercializing innovative solutions for the treatment of Type 2 diabetes. Founded in 2006 and headquartered in Bridgewater, New Jersey, the company offered the V-Go, a wearable insulin delivery device designed for basal-bolus therapy, allowing patients to manage their insulin intake conveniently and discreetly. Valeritas was also working on additional products, including the V-Go Prefill, aimed at simplifying the device-filling process, and V-Go SIM, which would facilitate real-time tracking of dosing utilization. The company marketed its products through third-party wholesalers and medical supply distributors, aiming to enhance the health and quality of life for individuals living with diabetes. However, on June 30, 2020, Valeritas Holdings filed for Chapter 11 bankruptcy, leading to its cessation of operations.

Proteolix is a biopharmaceutical company focused on discovering, developing, and commercializing innovative therapies targeting protein degradation pathways to address cancer and autoimmune diseases. The company’s lead product is a pioneering proteasome inhibitor, designed to evaluate safety and efficacy in treating multiple myeloma and various malignancies. In addition to this lead product, Proteolix is advancing a pipeline of novel proteasome inhibitors, which includes an oral formulation and a selective immunoproteasome inhibitor. These therapies aim to provide healthcare professionals with effective treatment options for specific hematologic cancers by inhibiting the cellular proteasome.

ChannelAdvisor is a provider of cloud-based multichannel commerce solutions aimed at enhancing the e-commerce operations of brands and retailers. The company's platform facilitates the management of various sales channels, enabling users to streamline processes such as inventory availability and pricing optimization. By offering data analytics capabilities, ChannelAdvisor empowers its clients to improve their online performance and competitiveness. The company is dedicated to helping businesses expand their reach, connect with consumers throughout the buying cycle, and ultimately drive sales growth from a centralized platform.

GluMetrics, Inc. is a medical device company based in Irvine, California, founded in 2005. It specializes in developing tools for clinicians to improve the care of critically ill patients. The company's primary product, GluCath, is an intravascular continuous glucose monitoring system designed to measure blood sugar levels in hospitalized patients. By providing real-time glucose data, GluMetrics aims to enhance patient management and outcomes in critical care settings.

AltaRock Energy, Inc., established in 2007, is a geothermal energy technology and services company. Headquartered in Seattle, Washington, with a technology development office in Sausalito, California, AltaRock specializes in the research, development, and commercialization of geothermal systems. The company's core business involves creating and enhancing geothermal power sites, offering services such as development, management, operations, and reservoir maintenance. AltaRock's innovative Engineered Geothermal Systems (EGS) technology aims to provide clean, affordable, and widely accessible renewable energy. The company's leadership includes Don O'Shei, Chief Executive Officer, and Susan Petty, President and Chief Technology Officer.

Qumu Corporation specializes in providing comprehensive tools for enterprises to create, manage, secure, distribute, and measure live and on-demand video content. The company offers an end-to-end solution that includes software licenses, server appliances, software-enabled devices, and a cloud-hosted software-as-a-service platform. In addition to these products, Qumu provides maintenance, support, and professional services. Its solutions cater to a variety of sectors, including banking, finance, insurance, manufacturing, telecom, technology, and healthcare, as well as government entities, through both direct sales and partnerships. Founded in 1978 and headquartered in Minneapolis, Minnesota, Qumu was formerly known as Rimage Corporation before rebranding in 2013. The majority of the company's revenue is generated from North America, with additional markets in Europe and Asia.

Rive Technology is a clean energy company focused on advancing catalyst technology for petroleum refining. The company has developed a proprietary technology, originally conceived at MIT, that enhances traditional zeolite catalysts by introducing novel channels of medium pore size. This innovation allows large hydrocarbon molecules to be processed more efficiently, significantly increasing the yield of transportation fuels such as gasoline and diesel per barrel of crude oil. Rive's catalysts can be integrated seamlessly into existing refinery operations, enabling refiners to boost throughput and profitability with minimal capital investment. By improving product yields and process efficiency, Rive's technology supports the transition to more sustainable energy practices within the petroleum industry.

Wakonda Technologies was founded in 2005 by Dr. Les Fritzemeier and Professor Ryne Raffaelle of the Rochester Institute of Technology. The company was established to exploit the intersection of their respective skills in metallurgical processing and advanced photovoltaic devices. Wakonda was started in Rochester NY and used the facilities at RIT, Cornell University and several government agencies to conduct proof of concept experiments. In 2008, the company moved to Massachusetts to accelerate product development and early commercialization. Wakonda has received several honors over its short history, winning the first ever Golden Horseshoe Business Challenge in upstate NY and being named the National Renewable Energy Laboratory's Entrepreneur of the Year in 2007.

[x+1] is a recognized leader in marketing technology, specifically noted for its advanced capabilities in both data management and demand-side platform services. The company offers the Origin Platform, a comprehensive programmatic marketing hub that enables brands to engage effectively with their audiences through various digital channels. Utilizing its Origin Data Management Platform, which combines first and third-party data with a Predictive Optimization Engine, [x+1] facilitates targeted audience engagement across online display, mobile, email, and other digital mediums. This capability has made [x+1] a trusted partner for many top brands, particularly in the financial services sector. Headquartered in New York City, [x+1] also has offices in Connecticut, Illinois, Michigan, and California.

Solar Junction is a manufacturer of high efficiency III-V multi-junction solar cells based on ASLAM ™ materials. The company is dedicated to providing the industry’s highest efficiency solar cells to enable CPV as a cost effective energy solution. Founded in 2007, Solar Junction is headquartered in San Jose, California. Investors include New Enterprise Associates, Draper Fisher Jurvetson and Advanced Technology Ventures.

Cenzic specializes in application security testing for enterprise software, focusing on Software as a Service (SaaS) solutions. The company employs advanced techniques that extend beyond traditional signature-based tools to automatically identify vulnerabilities within applications. Cenzic's offerings include security testing for mobile, web, and cloud applications, as well as comprehensive training programs in security and penetration testing. Additionally, Cenzic provides professional implementation training and consulting services, both on-site and remotely, to enhance software engineering practices and bolster application security for its clients.

Handango specializes in providing smartphone applications for various platforms, including BlackBerry, Palm, Windows Mobile, Symbian OS, and Linux. The company boasts a catalog of over 140,000 applications, covering a wide range of categories such as games, business, entertainment, and productivity tools. Handango collaborates with a vast network of content partners, exceeding 23,000, to distribute its mobile applications to millions of consumers globally. Users can conveniently download applications through the Handango website, partner sites, SD cards, and its proprietary on-device catalog, InHand. This platform enables direct purchases and over-the-air downloads, enhancing user accessibility. Handango's expertise in mobile content has attracted partnerships with notable companies in the industry, reinforcing its position as a key player in the mobile application market.

Hydra Biosciences is a biopharmaceutical company located in Cambridge, Massachusetts, focused on developing innovative drugs for pain, inflammation, cardiovascular diseases, and other conditions. The company utilizes its expertise in novel ion channels, specifically targeting Transient Receptor Potential (TRP) ion channels, to create selective and safer therapeutic options. Hydra employs proprietary high-throughput screening platforms that facilitate the identification and development of drug candidates aimed at addressing significant unmet medical needs. With a strong intellectual property portfolio and a flexible approach to drug discovery, Hydra differentiates itself from traditional biopharmaceutical firms. The company has attracted substantial financing from notable investors, enabling it to advance its drug development programs effectively.

Aperio Technologies is a leading provider of digital pathology solutions, serving hospitals, reference labs, and pharmaceutical and research institutions globally. The company's comprehensive product portfolio enhances patient care by improving quality assurance, streamlining workflows, and facilitating access to targeted therapies. Aperio offers a range of products, including ScanScope scanners, Spectrum image management software, the SecondSlide slide sharing service, and various image analysis tools. These products are FDA cleared for specific clinical applications and are also intended for research and educational purposes. Through its innovative solutions, Aperio aims to improve the skills of pathologists and contribute to advancements in the field of pathology.

Coskata, Inc. is a renewable energy company focused on producing liquid fuels through advanced biological processes. The company utilizes proprietary microorganisms and innovative bioreactor designs to convert various feedstocks, including natural gas, wood, and waste materials, into ethanol. By developing technologies for processing bio-refuse and synthesizing gas, Coskata aims to provide a sustainable solution for fuel production that supports economic growth, environmental protection, and national security. Through its expertise in molecular biology and process engineering, the company enables the transformation of diverse resources into valuable fuels and chemicals.

PolyRemedy offers integrated wound management systems designed to increase consistency by extending wound care expertise to the point of care. The PolyRemedy Personalized Woundcare System (PWS) enables clinicians to document care through easy-to-use, web-based assessment tools and order personalized wound dressings, while also providing critical and unprecedented visibility into wound care data. It was founded in 2004 and is headquartered in Concord, Massachusetts.