Highline Capital Management

Highline Capital Management, L.P. is an employee-owned hedge fund sponsor based in New York City, founded in 1995. The firm specializes in managing pooled investment vehicles, primarily focusing on mid and large capitalization equities in the United States. Highline employs fundamental research to inform its investment strategies, aiming to create portfolios that offer attractive risk and return profiles. The firm complements its in-house research with external insights to enhance its investment decisions. Highline Capital Management is recognized for its successful risk-adjusted performance relative to U.S. equity market indices.

Jacob Doft

Founder and CEO

7 past transactions

Network Bio

Seed Round in 2025
Network Bio operates a clinical and molecular data library focused on facilitating precision medicine for common human diseases. Its platform serves as a centralized repository for clinical and molecular data, allowing researchers to analyze patterns and correlations. This analysis can lead to the development of new treatments and diagnostic tools, thereby advancing medical research and improving patient outcomes.

Proscia

Series C in 2024
Proscia Inc. is a Philadelphia-based company that develops a cloud-based digital pathology platform aimed at enhancing cancer diagnosis and improving patient outcomes. Founded in 2014, Proscia's platform leverages advanced computing technologies to analyze data that is not perceptible to the human eye. By transforming this hidden data into actionable insights, the platform supports routine pathology operations and aids physicians in accelerating the development of life-saving medical advancements.

Proscia

Series C in 2022
Proscia Inc. is a Philadelphia-based company that develops a cloud-based digital pathology platform aimed at enhancing cancer diagnosis and improving patient outcomes. Founded in 2014, Proscia's platform leverages advanced computing technologies to analyze data that is not perceptible to the human eye. By transforming this hidden data into actionable insights, the platform supports routine pathology operations and aids physicians in accelerating the development of life-saving medical advancements.

Strata Oncology

Series C in 2021
Strata Oncology, Inc. is a precision oncology company focused on improving cancer care by increasing patient access to clinical trials and expediting drug approvals. The company operates a national precision oncology platform that connects patient screening to streamlined enrollment in mutation-matched clinical trials. Strata collaborates with major healthcare systems to facilitate the genomic sequencing of cancer patients' biopsies in high-throughput laboratories, providing oncologists with timely tumor profiles that inform treatment decisions. Its offerings include The Strata Trial, StrataNGS for targeted DNA and RNA sequencing, and StrataPOINT, which integrates electronic medical records with molecular data to ensure comprehensive testing and follow-up for eligible patients. Strata also manages a portfolio of pharmaceutical-sponsored trials tailored to specific biomarkers and operates the Strata Precision Oncology Network, a collaborative effort among cancer centers to advance precision medicine. Founded in 2015 and headquartered in Ann Arbor, Michigan, Strata was previously known as Strata Oncology Research, Inc. until its name change in May 2016.

ATAI Life Sciences

Series D in 2021
ATAI Life Sciences AG is a biotechnology company based in Munich, Germany, with additional offices in Berlin and London. Founded in 2018, the company focuses on developing innovative therapies for mental health disorders, including depression, anxiety, and substance use disorders. ATAI utilizes psychedelic compounds and other therapeutic methods to address these conditions, collaborating with various partners and research institutions to enhance its drug development pipeline. Its clinical-stage product portfolio features therapies such as COMP360 (Psilocybin therapy), PCN-101 (R-ketamine), and others derived from compounds like MDMA and ibogaine. By working with experts in the field, ATAI aims to ensure the efficacy and safety of its treatments. The company has garnered recognition for its contributions to mental health research and has secured partnerships and funding to further its initiatives in transforming mental health care.

Longboard Pharmaceuticals

Series A in 2020
Longboard Pharmaceuticals is a clinical-stage biopharmaceutical company based in San Diego, California, focused on developing innovative medicines for neurological diseases. The company's proprietary pipeline includes several product candidates, notably LP352, a next-generation 5-HT2C agonist intended for treating developmental and epileptic encephalopathies. Additionally, Longboard is evaluating LP143, a full agonist of the cannabinoid type 2 receptor, which targets conditions such as amyotrophic lateral sclerosis and Parkinson's disease, as well as LP659, a selective modulator for multiple central nervous system neuroinflammatory disorders. Longboard Pharmaceuticals aims to optimize pharmacology and pharmacokinetics across its drug candidates, enhancing therapeutic outcomes for patients with rare neurological conditions. The company was incorporated in 2020 and was previously known as Arena Neuroscience, Inc.

Passage Bio

Series B in 2019
Passage Bio is a genetic medicines company based in Philadelphia, Pennsylvania, specializing in the development of therapies for rare monogenic central nervous system (CNS) diseases. Founded in 2017, the company aims to create a portfolio of five AAV-delivered therapeutics, targeting conditions such as GM1 Gangliosidosis, Frontotemporal dementia, and Krabbe Disease. Passage Bio collaborates closely with the University of Pennsylvania, leveraging its Gene Therapy Program for preclinical work while managing clinical development, regulatory affairs, manufacturing, and commercialization of its product candidates. The company also engages with the Orphan Disease Center for natural history studies, key opinion leader involvement, and patient advocacy.
Spot something off? Help us improve by flagging any incorrect or outdated information. Just email us at support@teaserclub.com. Your feedback is most welcome.