Bay City Capital

Bridge Medicines LLC offers drug discovery services. It focuses on developing technologies in academic institutions from human proof-of-concept to clinical development. The company develops inhibitors of ENL-YEATS for the treatment of acute leukemias, such as acute myelogenous leukemia and a series of orally active small molecule inhibitors of activated factor XII for the treatment of hereditary angioedema and other inflammatory disorders. Bridge Medicines LLC was founded in 2016 and is based in New York, New York.

SemBioSys Genetics Inc., a Canadian biotechnology company, announced today that it has signed a feasibility agreement with Dow AgroSciences LLC, of Indianapolis, Indiana, for the Stratosome(TM) Biologics System and its application to animal health biologics. Under the terms of the agreement, SemBioSys and Dow AgroSciences will engage in collaborative research with the aim of determining if the Stratosome(TM) Biologics System can enable the commercialisation of a Dow AgroSciences plant-made vaccine. Under the terms of the agreement, SemBioSys will receive upfront and milestone payments. Further terms of the agreement were not disclosed. " We believe that our Stratosome(TM) Biologics System, with its economic and functional benefits, makes it an outstanding platform for animal health products. We are extremely pleased to be working with Dow AgroSciences in developing their vaccine," said Andrew Baum, president and CEO of SemBioSys. "We are very pleased to be working with SemBioSys in evaluating the Stratosome(TM) technology and its application to plant-made biologics for the animal health industry," stated Butch Mercer, Global Business Leader, Animal Health and Nutrition for Dow AgroSciences This is the third funded development agreement announced by SemBioSys in the last six months. In December, SemBioSys announced that it had executed a development agreement with Martek Biosciences Corporation (Nasdaq: MATK) to co- develop value-added specialty oil products (DHA containing safflower oil) with potential pharmaceutical and nutraceutical applications. In February, SemBioSys announced that it had entered into an agreement with Syngenta for access to SemBioSys' proprietary oilbody based Stratosome(TM) Biologics and StratoCapture(TM) Purification Systems for the development of Syngenta's biologic products. About SemBioSys Genetics Inc. (www.sembiosys.com) Calgary, Alberta-based SemBioSys Genetics Inc. is a privately held biotechnology company focused on the development of therapeutic proteins and oils using its proprietary oilbody-based technology - the Stratosome(TM) Biologics System. Spun out of the University of Calgary in 1994, the company's investors include Bay City Capital, Dow AgroSciences Canada, Inc., Ventures West Management Inc., BDC Venture Capital, University Technologies International Inc., RBC Capital Partners and Maurice Moloney Ph.D. scientific founder and chief scientific officer. In addition to these investors, SemBioSys has received repayable contributions of CAD$5.5MM from Technology Partnerships Canada, an agency of Industry Canada, and CAD$4.9MM from AVAC Ltd. SemBioSys has partnerships with Syngenta Participations AG and Martek Biosciences for the use of its Stratosome(TM) technology for the development of therapeutic products.

Xilio Therapeutics is a biotechnology company advancing next-generation cancer immunotherapies designed to improve patient outcomes by unleashing the power of the immune system selectively at the site of the tumor. The company’s tumor-selective immunotherapies are based on its proprietary technology, which maximizes the potency of proven immuno-oncology therapies and restricts their activity to the tumor to minimize peripheral side effects. The broad applicability of these therapies across cancer types means that all patients could benefit from these potentially curative medicines. These tumor-selective therapies are designed to overcome the significant toxicities associated with validated IO therapies, such as IL-2 and aCTLA4, which have historically limited the number of patients that can be treated and prevented patients from completing full courses of treatment Xilio Therapeutics proprietary technology enables the explosion of therapeutic activity specifically within the tumor while reducing toxicity throughout the body a nod to the company name, Xilio, derived from the Latin term, Ex Nihilo, meaning creation or big-bang. The company applying its technology to build a broad pipeline of engineered antibodies, cytokines and chemokines as potential new options for people living with cancer. Xilio Therapeutics was founded in 2016 and is headquartered in Waltham, Massachusetts, United States.

Imara, Inc. is a clinical-stage biopharmaceutical company based in Boston, Massachusetts, focused on developing innovative therapeutics for patients with rare genetic disorders of hemoglobin, particularly sickle cell disease and beta-thalassemia. Founded in 2016, the company is advancing IMR-687, a once-daily oral therapy designed to be a potent small molecule inhibitor of PDE9. This therapeutic aims to address the significant health challenges associated with these conditions, which can lead to reduced healthy red blood cells and various complications. Imara was established following a collaboration between Cydan Development and H. Lundbeck A/S, with initial funding from notable life science investors.

Gossamer Bio is a San Diego-based company focused on the discovery and development of novel and differentiated therapeutic products, to address high unmet needs amongst various targeted patient populations. Founded by the former Receptos executive team, Gossamer Bio’s strategy will be to leverage an asset-rich in-licensing environment, with a focus on areas of high unmet need, utilizing a team with a strong track record of execution in immunology, inflammation, fibrosis and oncology.

KBP Biosciences Co., Ltd. is a biotechnology company based in Jinan, China, with additional offices in Beijing, Japan, and the United States. Founded in 2002, the company focuses on the research and development of drugs targeting infectious and metabolic diseases. Its comprehensive research platform employs structure-based drug design, in vitro and cell-based biological screening, and pharmacodynamic and pharmacokinetic evaluation, alongside ADME profiling and pre-clinical animal pharmacology and toxicity analysis. KBP Biosciences also offers services related to the transfer of new drugs, licensing, and intellectual property protection, which includes patent scope analysis, novelty analysis, and patent writing and filing. The organization is committed to delivering innovative therapies to address unmet medical needs.

Oculis is a clinical-stage biotechnology company dedicated to developing innovative topical treatments for ophthalmic diseases affecting both the anterior and posterior segments of the eye. Founded in 2003 and headquartered in Reykjavik, Iceland, Oculis utilizes a unique drug delivery platform that enhances drug absorption through a novel technique, enabling effective treatment of conditions such as diabetic macular edema, uveitis, chronic dry eye syndrome, glaucoma, and diabetic retinopathy with simple eye drops. This approach allows for non-invasive treatment of diseases at the back of the eye, traditionally requiring more complex methods, while also reducing the frequency of applications needed for anterior eye conditions. Oculis is committed to improving patient outcomes and enhancing the quality of life for individuals with vision-related health issues.

Gritstone Bio is a biotechnology company focused on developing personalized cancer immunotherapies aimed at treating various cancer types and infectious diseases. The company is advancing its lead product candidates, GRANITE and SLATE, both of which are in Phase I/II clinical trials. GRANITE targets solid tumors, including metastatic non-small cell lung cancer and gastroesophageal cancer, while SLATE serves as an off-the-shelf immunotherapy for common solid tumors and mutation-positive cancers. Gritstone is committed to identifying therapeutic neo-antigens from individual patients' tumors to create novel treatments, leveraging the expertise of its scientific founders and management team. Founded in 2015 and headquartered in Emeryville, California, the company is also engaged in strategic collaborations to enhance its research and development efforts.

Kezar Life Sciences, Inc. is a clinical-stage biotechnology company based in South San Francisco, California, focused on developing novel small molecule therapeutics for unmet medical needs in autoimmunity and cancer. The company’s lead candidate, KZR-616, is a selective immunoproteasome inhibitor currently undergoing Phase 2 clinical trials for multiple autoimmune conditions, including lupus nephritis and autoimmune hemolytic anemia, as well as Phase 1b/2 trials for systemic lupus erythematosus. In addition to KZR-616, Kezar is advancing preclinical products, including KZR-TBD, aimed at treating oncology and autoimmune disorders. Founded in 2015, Kezar Life Sciences leverages insights into protein homeostasis, particularly the interplay between protein degradation and secretion, to drive its drug discovery efforts.

VYNE Therapeutics is a late-stage biopharmaceutical company that specializes in the development and commercialization of serlopitant, a treatment for pruritus associated with various dermatologic conditions, including atopic dermatitis, psoriasis, and prurigo nodularis. The company aims to address a significant unmet medical need, as there are currently no approved therapies in the United States that specifically target pruritus in these conditions. In addition to its focus on dermatologic applications, VYNE is also investigating serlopitant for refractory chronic cough, a persistent cough that lasts more than eight weeks despite treatment. Serlopitant acts as a selective small molecule inhibitor of the neurokinin 1 receptor and is administered as an oral tablet once daily. The company has completed Phase II clinical trials for pruritus related to various conditions and is planning to advance into Phase III trials for prurigo nodularis, anticipating further data to support its clinical development. VYNE Therapeutics is headquartered in Redwood City, California, and was established in 2011.

Twist Bioscience Corporation, a synthetic biology company, manufactures and sells synthetic DNA-based products. The company’s DNA synthesis platform enables the manufacturing of synthetic DNA by writing DNA on a silicon chip. It offers synthetic DNA-based products, including synthetic genes, tools for sample preparation, antibody libraries for drug discovery and development, and DNA as a digital data storage medium. The company has a collaboration agreement with ImmunoPrecise Antibodies Ltd. Twist Bioscience Corporation was founded in 2013 and is headquartered in South San Francisco, California.

Xeris Biopharma is a specialty pharmaceutical company focused on developing and commercializing ready-to-use injectable and infusible drug formulations. Utilizing its proprietary XeriSol and XeriJect technology platforms, the company delivers highly concentrated, liquid-stable formulations of peptides, small molecules, and proteins through various delivery methods, including syringes and auto-injectors. Xeris Biopharma's lead product is Gvoke, a ready-to-use glucagon for treating severe hypoglycemia, while its other products include Keveyis, the first FDA-approved treatment for primary periodic paralysis, and Recorlev, approved for endogenous hypercortisolemia in Cushing's Syndrome. The company is also advancing several product candidates in clinical trials, targeting conditions in endocrinology, neurology, and gastroenterology. Founded in 2005 and headquartered in Chicago, Illinois, Xeris Biopharma aims to improve patient care by providing easier-to-use therapies that enhance treatment outcomes.

Iterum Therapeutics plc is a clinical-stage pharmaceutical company based in Dublin, Ireland, focused on developing innovative anti-infectives to address the global challenge of multi-drug resistant pathogens. Founded in 2015, the company is advancing sulopenem, a novel penem anti-infective compound available in both oral and intravenous formulations. Currently in Phase III clinical trials, sulopenem aims to treat uncomplicated and complicated urinary tract infections, as well as complicated intra-abdominal infections. The company's goal is to provide effective solutions for serious infections caused by resistant bacteria, thereby improving patient outcomes and addressing the limitations of existing antibiotic treatments.

Bridge Medicines LLC offers drug discovery services. It focuses on developing technologies in academic institutions from human proof-of-concept to clinical development. The company develops inhibitors of ENL-YEATS for the treatment of acute leukemias, such as acute myelogenous leukemia and a series of orally active small molecule inhibitors of activated factor XII for the treatment of hereditary angioedema and other inflammatory disorders. Bridge Medicines LLC was founded in 2016 and is based in New York, New York.

Vtesse, Inc. develops drugs for patients suffering from rare diseases. The company focuses on conducting the clinical study of VTS-270 for the treatment of Niemann-Pick disease type C (NPC), as well as on conducting pre-clinical discovery and development of other novel drugs for NPC and other lysosomal storage diseases. Vtesse, Inc. is based in Gaithersburg, Maryland. As of April 3, 2017, Vtesse, Inc. operates as a subsidiary of Sucampo Pharmaceuticals, Inc.

Imara, Inc. is a clinical-stage biopharmaceutical company based in Boston, Massachusetts, focused on developing innovative therapeutics for patients with rare genetic disorders of hemoglobin, particularly sickle cell disease and beta-thalassemia. Founded in 2016, the company is advancing IMR-687, a once-daily oral therapy designed to be a potent small molecule inhibitor of PDE9. This therapeutic aims to address the significant health challenges associated with these conditions, which can lead to reduced healthy red blood cells and various complications. Imara was established following a collaboration between Cydan Development and H. Lundbeck A/S, with initial funding from notable life science investors.

Imara, Inc. is a clinical-stage biopharmaceutical company based in Boston, Massachusetts, focused on developing innovative therapeutics for patients with rare genetic disorders of hemoglobin, particularly sickle cell disease and beta-thalassemia. Founded in 2016, the company is advancing IMR-687, a once-daily oral therapy designed to be a potent small molecule inhibitor of PDE9. This therapeutic aims to address the significant health challenges associated with these conditions, which can lead to reduced healthy red blood cells and various complications. Imara was established following a collaboration between Cydan Development and H. Lundbeck A/S, with initial funding from notable life science investors.

Merus N.V. is a clinical-stage immuno-oncology company based in the Netherlands, focused on the discovery and development of bispecific antibody therapeutics. The company's pipeline includes several promising candidates, notably MCLA-128, currently in phase 2 clinical trials for metastatic breast cancer; MCLA-117, in phase I trials for acute myeloid leukemia; and MCLA-158, also in phase I trials for solid tumors. Additionally, Merus is advancing other bispecific antibody candidates, including MCLA-129 and MCLA-145, in collaboration with various pharmaceutical partners. The company employs a unique technology called Oligoclonics, which enables the production of a mixture of therapeutic antibodies from a single cell clone, aimed at targeting common antigens. Merus has established partnerships to enhance its research capabilities, such as its collaboration with Caris Life Sciences for detecting NRG1 fusions in cancer patients. Founded in 2003, Merus is headquartered in Utrecht and is dedicated to developing innovative treatments for cancer.

Vtesse, Inc. develops drugs for patients suffering from rare diseases. The company focuses on conducting the clinical study of VTS-270 for the treatment of Niemann-Pick disease type C (NPC), as well as on conducting pre-clinical discovery and development of other novel drugs for NPC and other lysosomal storage diseases. Vtesse, Inc. is based in Gaithersburg, Maryland. As of April 3, 2017, Vtesse, Inc. operates as a subsidiary of Sucampo Pharmaceuticals, Inc.

Interleukin Genetics, Inc. is a company that specializes in personalized health through genetic testing. It develops and sells genetic tests aimed at helping individuals improve their health and wellness. The company focuses on two main areas: providing genetic test products directly to consumers and through sales partners, and conducting research and development to create genetic tests in collaboration with partners for medical and dental applications. By offering personalized insights related to chronic diseases and health conditions, Interleukin Genetics aims to empower individuals with the information needed to make informed decisions about their health, including specific dietary and exercise recommendations. This approach aligns with their mission of enhancing preventive health measures and improving overall health outcomes.

SynGen Inc. specializes in the development, design, and manufacture of cell separation tools aimed at efficiently recovering target cells while depleting contaminants. The company's product portfolio includes advanced medical devices such as the SynGenX-1000 and SynGenX-2000 systems, which are closed sterile processing solutions for isolating stem and progenitor cells from umbilical cord blood and preparing platelet-rich plasma, respectively. Additionally, SynGen offers the CryoPRO-2 cryopreservation/storage bag set and a range of laboratory devices, including the SynGenX-Lab System and CryoPRO Workstation, which facilitate the extraction and preservation of valuable cell populations. The company also provides SynGen DataTrak software for data management and SynGenCellWashPRO for semi-automated cell washing processes. With a focus on innovative engineering, SynGen's products serve critical roles in regenerative medicine, diagnostics, and clinical applications. Established in 2007, SynGen is headquartered in Sacramento, California, with operations extending to Runcorn, United Kingdom, and operates as a subsidiary of ThermoGenesis Corp.

Civitas Therapeutics is a biopharmaceutical company dedicated to developing therapies for pulmonary delivery. The company focuses on creating innovative treatments for central nervous system and respiratory disorders, with a particular emphasis on conditions such as multiple sclerosis and spinal cord injuries. Civitas Therapeutics aims to improve the health and quality of life for patients across the United States through its specialized drug delivery systems.

Dermira is a specialty biopharmaceutical company focused on bringing innovative and differentiated products to dermatologists and their patients. Dermira’s portfolio of five product candidates targets significant market opportunities. It was founded in 2010 and headquartered in Menlo Park, California.

Madrigal Pharmaceuticals is a clinical-stage biopharmaceutical company that develops and commercializes therapeutic candidates for cardiovascular, metabolic, and liver diseases. The company's lead product, MGL-3196, is an orally administered, small-molecule, liver-directed thyroid hormone receptor β-selective agonist currently in Phase III clinical trials for the treatment of non-alcoholic steatohepatitis (NASH). Additionally, Madrigal is developing MGL-3745, another THR-β-selective small molecule, which is in preclinical trials for NASH and hyperlipidemia. The company aims to address significant unmet medical needs across various conditions, including diabetes and dyslipidemia. Founded in 2011 and headquartered in West Conshohocken, Pennsylvania, Madrigal Pharmaceuticals collaborates with Hoffmann-La Roche to further its research and commercialization efforts.

Fabric Genomics is making genomics-driven precision medicine a reality. We provide clinical decision support software that enables clinical labs, hospital systems and country-sequencing programs to gain actionable genomic insights, resulting in faster and more accurate diagnoses and reduced turnaround time. Fabric’s end-to-end genomic analysis platform incorporates proven AI algorithms, and has applications in both hereditary disease and oncology. Headquartered in Oakland, California, Fabric Genomics was founded by industry veterans and innovators with a deep understanding of bioinformatics, large-scale genomics and clinical diagnostics.

Galecto, Inc. is a clinical-stage biotechnology company founded in 2011, focused on developing small molecules to treat severe diseases, particularly fibrosis and cancer. The company leverages over a decade of research on the roles of galectin-3 and lysyl oxidase-like 2 (LOXL2) in fibrotic processes. Its therapeutic approach includes small-molecule inhibitors targeting these proteins. Galecto's leading product candidate, GB0139, is aimed at treating severe fibrotic lung diseases, notably idiopathic pulmonary fibrosis, while another candidate, GB1211, is a selective oral galectin-3 inhibitor intended for managing fibrosis related to non-alcoholic steatohepatitis. With a robust patent portfolio, Galecto is positioned to address critical unmet medical needs in the treatment of fibrotic and related diseases.

PharmAkea, Inc. is a biopharmaceutical company located in San Diego, California, focused on discovering and developing small molecule therapeutics for cancer and fibrotic diseases. Founded in 2012, the company is advancing its lead program, which features a small molecule inhibitor targeting LOXL2. PharmAkea aims to develop high-quality drug candidates against protein targets associated with fibroproliferative conditions. The company has formed a strategic collaboration with Celgene Corporation to utilize its proprietary drug discovery platform and develop innovative small molecule therapies aimed at treating fibrotic diseases.

Merus N.V. is a clinical-stage immuno-oncology company based in the Netherlands, focused on the discovery and development of bispecific antibody therapeutics. The company's pipeline includes several promising candidates, notably MCLA-128, currently in phase 2 clinical trials for metastatic breast cancer; MCLA-117, in phase I trials for acute myeloid leukemia; and MCLA-158, also in phase I trials for solid tumors. Additionally, Merus is advancing other bispecific antibody candidates, including MCLA-129 and MCLA-145, in collaboration with various pharmaceutical partners. The company employs a unique technology called Oligoclonics, which enables the production of a mixture of therapeutic antibodies from a single cell clone, aimed at targeting common antigens. Merus has established partnerships to enhance its research capabilities, such as its collaboration with Caris Life Sciences for detecting NRG1 fusions in cancer patients. Founded in 2003, Merus is headquartered in Utrecht and is dedicated to developing innovative treatments for cancer.

Cydan Development, Inc. is a company focused on the development and commercialization of therapies for orphan and rare diseases, with a particular emphasis on rare genetic disorders. Founded in 2012 and located in Lincoln, Massachusetts, Cydan functions as an orphan drug accelerator, identifying and de-risking compounds with therapeutic potential. The organization conducts comprehensive studies to support the further development of treatments by biotechnology firms. Cydan has worked on therapies for conditions such as Niemann-Pick Disease Type C and IMR-687 for sickle cell disease. The company leverages strong relationships with academic institutions and patient advocacy groups, along with deep expertise in drug development, to foster successful product commercialization and advance treatment options for underserved patient populations.

Civitas Therapeutics is a biopharmaceutical company dedicated to developing therapies for pulmonary delivery. The company focuses on creating innovative treatments for central nervous system and respiratory disorders, with a particular emphasis on conditions such as multiple sclerosis and spinal cord injuries. Civitas Therapeutics aims to improve the health and quality of life for patients across the United States through its specialized drug delivery systems.

TRIA Beauty, Inc. specializes in the development and marketing of light-based medical devices designed for consumer use in skincare and beauty treatments. The company offers a range of products, including a hand-held diode laser for hair removal, a blue light device targeting acne-causing bacteria, a fractional non-ablative laser for skin rejuvenation, and an eye wrinkle correcting laser. These devices provide effective solutions that allow users to achieve professional results at home. TRIA Beauty's products are available through its e-commerce platform and various retail channels, including television and physical stores, across multiple regions, including the United States, Japan, and several European countries. Founded in 2003 and headquartered in Dublin, California, TRIA Beauty was previously known as SpectraGenics, Inc. before rebranding in 2008.

Aviir is a venture-funded biotechnology company developing cutting-edge, diagnostic tests enabling accurate diagnosis and prognosis of cardiovascular disease. The company’s proprietary technology is based on ten years of research at Stanford University, and combines the scientific founder’s deep understanding of biomarker assay development and advanced biostatistics. Aviir has pursued an aggressive commercialization strategy, and initial products, including the MIRISK VP™ test, are currently on the market. The Aviir leadership team includes the founding scientists and highly experienced management.

Dermira is a specialty biopharmaceutical company focused on bringing innovative and differentiated products to dermatologists and their patients. Dermira’s portfolio of five product candidates targets significant market opportunities. It was founded in 2010 and headquartered in Menlo Park, California.

Interleukin Genetics, Inc. is a company that specializes in personalized health through genetic testing. It develops and sells genetic tests aimed at helping individuals improve their health and wellness. The company focuses on two main areas: providing genetic test products directly to consumers and through sales partners, and conducting research and development to create genetic tests in collaboration with partners for medical and dental applications. By offering personalized insights related to chronic diseases and health conditions, Interleukin Genetics aims to empower individuals with the information needed to make informed decisions about their health, including specific dietary and exercise recommendations. This approach aligns with their mission of enhancing preventive health measures and improving overall health outcomes.

Nabsys develops semiconductor-based tools for genomic analysis. The company has pioneered the technology of electronic high-definition mapping which is capable of analyzing entire genomes, in very large fragments (100,000 bp and higher) traveling at high velocity (greater than 1 million base pairs per second). Nabsys was the first company to receive a “1000 Genome” award from the National Human Genome Research Institute of the National Institutes of Health for an electronic approach to DNA analysis. It was founded in 2004 and headquartered in Providence, Rhode Island.

Nevro Corp. is a medical device company that focuses on developing innovative solutions for patients suffering from chronic pain. Based in Redwood City, California, the company has created the Senza spinal cord stimulation (SCS) system, which is an evidence-based neuromodulation platform that includes the proprietary HF10 therapy. This therapy provides electrical impulses to alleviate pain and is controlled by patients through a remote device. Nevro's product offerings extend to the Senza II and Senza Omnia systems, which are designed for chronic pain management. The company markets its products primarily in the United States and utilizes a direct sales force, along with a network of sales agents and independent distributors, to reach its customers. Founded in 2006, Nevro aims to enhance the quality of life for individuals affected by debilitating pain through its advanced medical technologies.

Aviir is a venture-funded biotechnology company developing cutting-edge, diagnostic tests enabling accurate diagnosis and prognosis of cardiovascular disease. The company’s proprietary technology is based on ten years of research at Stanford University, and combines the scientific founder’s deep understanding of biomarker assay development and advanced biostatistics. Aviir has pursued an aggressive commercialization strategy, and initial products, including the MIRISK VP™ test, are currently on the market. The Aviir leadership team includes the founding scientists and highly experienced management.

Ascendancy Healthcare specializes in facilitating the commercialization of therapeutic products in China and other emerging markets. The company offers tailored partnership solutions to address the unique challenges faced by businesses entering these regions. By providing clinical, regulatory, and commercial expertise, along with funding support, Ascendancy helps companies navigate the complexities of bringing products from the United States, Europe, and Japan to high-growth Asian markets. The firm is focused on meeting unmet medical needs and optimizing product growth in these dynamic environments. Ascendancy is privately held and backed by investors such as Bay City Capital and IndUS Growth Partners.

Molecular diagnostic company focused on making multiplexed molecular testing both affordable and practical for any laboratory to perform. The company’s IDbox™ system and single-use cassette will circumvent long-standing barriers of costs, automation and performance facilitating in-house lab testing for actionable results. In July 2012, GenturaDx was acquired by Luminex Corp. (NASDAQ:LMNX).

SynGen Inc. specializes in the development, design, and manufacture of cell separation tools aimed at efficiently recovering target cells while depleting contaminants. The company's product portfolio includes advanced medical devices such as the SynGenX-1000 and SynGenX-2000 systems, which are closed sterile processing solutions for isolating stem and progenitor cells from umbilical cord blood and preparing platelet-rich plasma, respectively. Additionally, SynGen offers the CryoPRO-2 cryopreservation/storage bag set and a range of laboratory devices, including the SynGenX-Lab System and CryoPRO Workstation, which facilitate the extraction and preservation of valuable cell populations. The company also provides SynGen DataTrak software for data management and SynGenCellWashPRO for semi-automated cell washing processes. With a focus on innovative engineering, SynGen's products serve critical roles in regenerative medicine, diagnostics, and clinical applications. Established in 2007, SynGen is headquartered in Sacramento, California, with operations extending to Runcorn, United Kingdom, and operates as a subsidiary of ThermoGenesis Corp.

ThermoGenesis Holdings, Inc., based in Rancho Cordova, California, develops and commercializes automated technologies for cell-based therapeutics, particularly in the CAR-T immunotherapy sector. The company offers a comprehensive suite of solutions for clinical biobanking and point-of-care applications, including the CAR-TXpress platform, which enhances the manufacturing process for CAR-T therapies. Its product lineup includes the AXP Automated Cell Separation System for isolating stem and progenitor cells from umbilical cord blood, the BioArchive Automated Cryopreservation System for cryogenic storage, and the PXP Point-of-Care System for processing autologous stem cells at surgical centers. Additionally, ThermoGenesis is advancing its X-Series products for cell purification and the AR-TXpress Platform to meet the demands of large-scale cellular processing. Founded in 1986 and previously known as Cesca Therapeutics, the company has evolved to address critical needs in the field of immuno-oncology and cellular therapies.

Altheos, Inc. is an early stage biopharmaceutical company based in the San Francisco Bay area focused on development of highly promising near-clinical and clinical stage novel small molecule drugs. Altheos, Inc. completed $20MM series A financing in March 2010 led by Bay City Capital with participation from Novo A/S, Canaan Partners, Life Science Angels and Atheneos Capital. The financing will be used primarily for the development of ATS907, a selective Rho-kinase inhibitor for topical treatment of glaucoma that Altheos licensed from a Japanese pharmaceutical company. The license also includes a series of highly active compounds specifically for topical treatment for glaucoma.

Aviir is a venture-funded biotechnology company developing cutting-edge, diagnostic tests enabling accurate diagnosis and prognosis of cardiovascular disease. The company’s proprietary technology is based on ten years of research at Stanford University, and combines the scientific founder’s deep understanding of biomarker assay development and advanced biostatistics. Aviir has pursued an aggressive commercialization strategy, and initial products, including the MIRISK VP™ test, are currently on the market. The Aviir leadership team includes the founding scientists and highly experienced management.

Dermira is a specialty biopharmaceutical company focused on bringing innovative and differentiated products to dermatologists and their patients. Dermira’s portfolio of five product candidates targets significant market opportunities. It was founded in 2010 and headquartered in Menlo Park, California.

Nevro Corp. is a medical device company that focuses on developing innovative solutions for patients suffering from chronic pain. Based in Redwood City, California, the company has created the Senza spinal cord stimulation (SCS) system, which is an evidence-based neuromodulation platform that includes the proprietary HF10 therapy. This therapy provides electrical impulses to alleviate pain and is controlled by patients through a remote device. Nevro's product offerings extend to the Senza II and Senza Omnia systems, which are designed for chronic pain management. The company markets its products primarily in the United States and utilizes a direct sales force, along with a network of sales agents and independent distributors, to reach its customers. Founded in 2006, Nevro aims to enhance the quality of life for individuals affected by debilitating pain through its advanced medical technologies.

Aviir is a venture-funded biotechnology company developing cutting-edge, diagnostic tests enabling accurate diagnosis and prognosis of cardiovascular disease. The company’s proprietary technology is based on ten years of research at Stanford University, and combines the scientific founder’s deep understanding of biomarker assay development and advanced biostatistics. Aviir has pursued an aggressive commercialization strategy, and initial products, including the MIRISK VP™ test, are currently on the market. The Aviir leadership team includes the founding scientists and highly experienced management.

Conatus Pharmaceuticals Inc. is a biotechnology company that specializes in developing innovative therapeutics for liver diseases and chronic conditions with significant unmet medical needs. Founded in 2005 and headquartered in San Diego, California, the company has focused on its lead product candidate, Emricasan, an orally active caspase protease inhibitor currently in Phase IIb clinical trials for various liver-related conditions, including post-orthotopic liver transplant complications and liver fibrosis linked to nonalcoholic steatohepatitis. Additionally, Conatus is advancing CTS-2090, an orally active inhibitor of caspase 1, which is in the preclinical stage for treating chronic diseases associated with inflammasome pathways. The company has also entered into a collaboration agreement with Novartis to conduct three Phase IIb clinical trials. In May 2020, Conatus Pharmaceuticals was acquired by Histogen Inc. in a reverse merger transaction.

NextWave Pharmaceuticals is a Cupertino, California-based pharmaceutical company that specializes in the development and commercialization of innovative drug delivery technologies. The company primarily focuses on creating once-daily liquid medications for the treatment of attention deficit/hyperactivity disorder (ADHD). By leveraging its proprietary technology, NextWave aims to provide effective treatment options that enhance patient compliance and address disorders related to the central nervous system.

Accriva Diagnostics specializes in near patient testing systems and advanced diagnostic solutions, focusing on point-of-care cardiovascular diagnostics. Founded in 2009 and based in San Diego, California, the company offers a variety of products designed to deliver timely and precise medical information to enhance treatment outcomes. Its product range includes compact immunoassay analyzers, hematology analyzers, high sensitivity immunoassay analyzers, and clinical chemistry analyzers. Notable devices include the Avoximeter whole blood oximeter and co-oximeter, the HemoChron coagulation systems, and various incision devices for blood sampling. Accriva Diagnostics aims to support healthcare providers in hospitals and critical care settings by improving the measurement of blood coagulation and platelet response.

IDEV Technologies is an emerging growth medical device company focused on the development of products for endovascular and interventional applications. Currently, IDEV markets SUPERA, a novel self-expanding nitinol stent. Using a patented interwoven design, SUPERA offers improved flexibility, radial strength, and kink and crush resistance compared to other marketed stents. SUPERA is currently approved for use in the treatment of biliary strictures in the US. IDEV is currently enrolling patients in the SUPERB IDE trial to study SUPERA's safety and efficacy when used in the superficial femoral artery (SFA).

EnteroMedics® Inc. is the developer of vBloc® neurometabolic therapy, delivered by a pacemaker-like device called the Maestro® Rechargeable System, a first-in-class weight loss treatment for obesity and obesity related risk factors, such as high blood pressure or high cholesterol levels. vBloc Therapy is a non-anatomy altering or restricting, reversible therapy that allows patients to safely lose weight by helping patients feel less hungry, reduce the amount of food eaten at a meal, and feel full longer in between meals.

Altheos, Inc. is an early stage biopharmaceutical company based in the San Francisco Bay area focused on development of highly promising near-clinical and clinical stage novel small molecule drugs. Altheos, Inc. completed $20MM series A financing in March 2010 led by Bay City Capital with participation from Novo A/S, Canaan Partners, Life Science Angels and Atheneos Capital. The financing will be used primarily for the development of ATS907, a selective Rho-kinase inhibitor for topical treatment of glaucoma that Altheos licensed from a Japanese pharmaceutical company. The license also includes a series of highly active compounds specifically for topical treatment for glaucoma.

Ion Torrent, a wholly-owned subsidiary of [Life Technologies](/organization/life-technologies), has pioneered an entirely new approach to sequencing that enables a direct connection between chemical and digital information. Ion Torrent™ technology doesn't use light—it's the first commercial PostLight™ sequencing technology. Instead, Ion Torrent marries simple chemistry to incredibly powerful, proven semiconductor technology—it's Watson meets Moore. The result is a sequencing system that is simpler, faster, more cost effective and scalable than any other technology available. The company's goal is to democratize sequencing and make this critical technology available to every lab.

Merus N.V. is a clinical-stage immuno-oncology company based in the Netherlands, focused on the discovery and development of bispecific antibody therapeutics. The company's pipeline includes several promising candidates, notably MCLA-128, currently in phase 2 clinical trials for metastatic breast cancer; MCLA-117, in phase I trials for acute myeloid leukemia; and MCLA-158, also in phase I trials for solid tumors. Additionally, Merus is advancing other bispecific antibody candidates, including MCLA-129 and MCLA-145, in collaboration with various pharmaceutical partners. The company employs a unique technology called Oligoclonics, which enables the production of a mixture of therapeutic antibodies from a single cell clone, aimed at targeting common antigens. Merus has established partnerships to enhance its research capabilities, such as its collaboration with Caris Life Sciences for detecting NRG1 fusions in cancer patients. Founded in 2003, Merus is headquartered in Utrecht and is dedicated to developing innovative treatments for cancer.

Aviir is a venture-funded biotechnology company developing cutting-edge, diagnostic tests enabling accurate diagnosis and prognosis of cardiovascular disease. The company’s proprietary technology is based on ten years of research at Stanford University, and combines the scientific founder’s deep understanding of biomarker assay development and advanced biostatistics. Aviir has pursued an aggressive commercialization strategy, and initial products, including the MIRISK VP™ test, are currently on the market. The Aviir leadership team includes the founding scientists and highly experienced management.

Calypso Medical Technologies, based in Seattle, is a privately held medical device company specializing in tumor localization technology. The company's proprietary system employs miniaturized implanted devices known as Beacon electromagnetic transponders to continuously and accurately track the location of tumors, enhancing the precision and management of radiation therapy delivery. This technology is particularly aimed at body-wide cancers that are commonly treated with radiation. Calypso's products have received FDA 510(k) clearance for use in the prostate and post-operative prostatic bed, ensuring compliance with regulatory standards. The company has established strategic partnerships with leading organizations in the medical field, including Varian Medical Systems, Siemens Medical Systems, Elekta Corporation, and Philips Medical, to further its mission of improving cancer treatment outcomes.

Aviir is a venture-funded biotechnology company developing cutting-edge, diagnostic tests enabling accurate diagnosis and prognosis of cardiovascular disease. The company’s proprietary technology is based on ten years of research at Stanford University, and combines the scientific founder’s deep understanding of biomarker assay development and advanced biostatistics. Aviir has pursued an aggressive commercialization strategy, and initial products, including the MIRISK VP™ test, are currently on the market. The Aviir leadership team includes the founding scientists and highly experienced management.

Epizyme, Inc. is a late-stage biopharmaceutical company based in Cambridge, Massachusetts, focused on developing epigenetic medicines for cancer and other diseases. The company has achieved a significant milestone with its approved product, Tazemetostat, which is used for treating metastatic or locally advanced epithelioid sarcoma in the United States. Additionally, Tazemetostat is being investigated in combination therapies for various cancers, including relapsed and refractory follicular lymphoma and high-risk diffuse large B-cell lymphoma. Epizyme is also engaged in developing other drug candidates, such as pinometostat for acute myeloid leukemia and acute lymphoblastic leukemia, alongside inhibitors targeting PRMT5 and PRMT1 for solid tumors and blood cancers. The company collaborates with several industry leaders and research organizations to advance its innovative therapeutic programs, reflecting its commitment to translating epigenetic research into effective treatments. Founded in 2007, Epizyme aims to reshape cancer treatment through its focus on molecularly targeted drugs.

Aviir is a venture-funded biotechnology company developing cutting-edge, diagnostic tests enabling accurate diagnosis and prognosis of cardiovascular disease. The company’s proprietary technology is based on ten years of research at Stanford University, and combines the scientific founder’s deep understanding of biomarker assay development and advanced biostatistics. Aviir has pursued an aggressive commercialization strategy, and initial products, including the MIRISK VP™ test, are currently on the market. The Aviir leadership team includes the founding scientists and highly experienced management.

Hyperion Therapeutics, Inc. is a biopharmaceutical company dedicated to developing and commercializing therapeutics for orphan diseases, primarily focusing on urea cycle disorders (UCD) and hepatic encephalopathy. Headquartered in Brisbane, California, the company offers RAVICTI, a nitrogen-binding agent for the chronic management of UCD in both adult and pediatric patients, along with BUPHENYL and AMMONAPS therapies targeting specific UCD subtypes. Additionally, Hyperion is working on glycerol phenylbutyrate, an active pharmaceutical ingredient in RAVICTI, aimed at treating hepatic encephalopathy. Founded in 2006, Hyperion operates as a subsidiary of Horizon Pharma USA, Inc. since May 2015, and it remains committed to addressing the needs of underserved patient populations through its innovative treatments.

Sunesis is an emerging biopharmaceutical company creating new medicines to improve the lives of people with cancer. They are building a pipeline of drugs that selectively block critical mechanisms required for tumor growth and survival. The fight against cancer is an enormous mission that requires an integrated approach fueled by a commitment to innovation.

Via Pharmaceuticals is a biotechnology company in the development stage that specializes in creating small-molecule drugs aimed at treating cardiovascular and metabolic diseases. The company is particularly focused on addressing inflammation in the blood vessel wall, which is a key factor in the progression of atherosclerosis and its associated complications, such as heart attacks and strokes. By targeting these significant unmet medical needs, Via Pharmaceuticals is working to advance its pipeline of therapies to improve patient outcomes in the realm of cardiovascular health.

Accriva Diagnostics specializes in near patient testing systems and advanced diagnostic solutions, focusing on point-of-care cardiovascular diagnostics. Founded in 2009 and based in San Diego, California, the company offers a variety of products designed to deliver timely and precise medical information to enhance treatment outcomes. Its product range includes compact immunoassay analyzers, hematology analyzers, high sensitivity immunoassay analyzers, and clinical chemistry analyzers. Notable devices include the Avoximeter whole blood oximeter and co-oximeter, the HemoChron coagulation systems, and various incision devices for blood sampling. Accriva Diagnostics aims to support healthcare providers in hospitals and critical care settings by improving the measurement of blood coagulation and platelet response.

Cadence Pharmaceuticals is a biopharmaceutical company focused on in-licensing, developing and commercializing proprietary product candidates principally for use in the hospital setting. On May 4, 2010 Cadence resubmitted a New Drug Application for its investigational product candidate, OFIRMEVTM (acetaminophen) injection for the treatment of pain and fever in adults and children. The FDA has assigned a new Prescription Drug User Fee Act (PDUFA) action date for OFIRMEV of November 4, 2010.

Vivaldi Biosciences Inc., a clinical-stage biotechnology company, develops live attenuated influenza vaccines (LAIVs) for protection against seasonal influenza and preparedness against emerging pandemic influenza. It offers deltaFLU is an advanced, self-adjuvanting influenza vaccine, administered as a nasal spray. The company was founded in 2006 and is based in Fort Collins, Colorado.

Aviir is a venture-funded biotechnology company developing cutting-edge, diagnostic tests enabling accurate diagnosis and prognosis of cardiovascular disease. The company’s proprietary technology is based on ten years of research at Stanford University, and combines the scientific founder’s deep understanding of biomarker assay development and advanced biostatistics. Aviir has pursued an aggressive commercialization strategy, and initial products, including the MIRISK VP™ test, are currently on the market. The Aviir leadership team includes the founding scientists and highly experienced management.

Nevro Corp. is a medical device company that focuses on developing innovative solutions for patients suffering from chronic pain. Based in Redwood City, California, the company has created the Senza spinal cord stimulation (SCS) system, which is an evidence-based neuromodulation platform that includes the proprietary HF10 therapy. This therapy provides electrical impulses to alleviate pain and is controlled by patients through a remote device. Nevro's product offerings extend to the Senza II and Senza Omnia systems, which are designed for chronic pain management. The company markets its products primarily in the United States and utilizes a direct sales force, along with a network of sales agents and independent distributors, to reach its customers. Founded in 2006, Nevro aims to enhance the quality of life for individuals affected by debilitating pain through its advanced medical technologies.

NuPathe Inc. is a specialty pharmaceutical company dedicated to developing and commercializing innovative therapies for neurological and psychiatric disorders. The company's flagship product is Zecuity, a transdermal system utilizing sumatriptan for the acute treatment of migraines in adults. In addition to Zecuity, NuPathe is advancing a pipeline of product candidates, including NP201, designed for the continuous treatment of Parkinson's disease, and NP202, aimed at the long-term management of schizophrenia and bipolar disorder. Both candidates leverage the company's proprietary Long-Acting Delivery technology, which facilitates extended medication release through biodegradable implants. Founded in 2005 and based in Malvern, Pennsylvania, NuPathe operates as a subsidiary of Teva Pharmaceutical Industries Limited. The company actively seeks partnerships to enhance the commercial potential of its products in the United States and internationally.

IDEV Technologies is an emerging growth medical device company focused on the development of products for endovascular and interventional applications. Currently, IDEV markets SUPERA, a novel self-expanding nitinol stent. Using a patented interwoven design, SUPERA offers improved flexibility, radial strength, and kink and crush resistance compared to other marketed stents. SUPERA is currently approved for use in the treatment of biliary strictures in the US. IDEV is currently enrolling patients in the SUPERB IDE trial to study SUPERA's safety and efficacy when used in the superficial femoral artery (SFA).

Aviir is a venture-funded biotechnology company developing cutting-edge, diagnostic tests enabling accurate diagnosis and prognosis of cardiovascular disease. The company’s proprietary technology is based on ten years of research at Stanford University, and combines the scientific founder’s deep understanding of biomarker assay development and advanced biostatistics. Aviir has pursued an aggressive commercialization strategy, and initial products, including the MIRISK VP™ test, are currently on the market. The Aviir leadership team includes the founding scientists and highly experienced management.

BrainCells develops and provides biopharmaceutical products for the treatment of central nervous system (CNS) diseases. It develops compounds that promote the growth of new neurons for the treatment of major depressive disorder (MDD), treatment resistant depression (TRD), and potentially Alzheimer’s disease (AD). The company's products include BCI-838 and BCI-632 which increase synaptic glutamate by inhibiting the mGlu2/3 auto-receptor. The company also builds a pipeline of clinical-stage programs to address unmet medical needs in the treatment of mood disorders, psychoses, cognition, brain repair syndromes, and other CNS disorders. The company was founded in 2003 and is based in San Diego, California.

Cadence Pharmaceuticals is a biopharmaceutical company focused on in-licensing, developing and commercializing proprietary product candidates principally for use in the hospital setting. On May 4, 2010 Cadence resubmitted a New Drug Application for its investigational product candidate, OFIRMEVTM (acetaminophen) injection for the treatment of pain and fever in adults and children. The FDA has assigned a new Prescription Drug User Fee Act (PDUFA) action date for OFIRMEV of November 4, 2010.

Aragon Surgical, Inc. is a privately owned company established in 2005 that focuses on developing and commercializing innovative surgical products aimed at enhancing patient safety and reducing operative time. The company collaborates with various surgeons to identify opportunities for improving surgical performance. Its devices are specifically designed to assist gynecologic surgeons, general surgeons, and surgical specialists in both laparoscopic and open procedures. Through its commitment to surgical innovation, Aragon Surgical seeks to address critical needs within the surgical community.

Aviir is a venture-funded biotechnology company developing cutting-edge, diagnostic tests enabling accurate diagnosis and prognosis of cardiovascular disease. The company’s proprietary technology is based on ten years of research at Stanford University, and combines the scientific founder’s deep understanding of biomarker assay development and advanced biostatistics. Aviir has pursued an aggressive commercialization strategy, and initial products, including the MIRISK VP™ test, are currently on the market. The Aviir leadership team includes the founding scientists and highly experienced management.

Aciex is focused on developing first-in-class products to fill unmet needs for ophthalmic therapeutics—products that will permit us to build a sustainable ophthalmic franchise. They believe their company is unique in both concept and products and timely in terms of the market, and they are pleased you have chosen to learn more about Aciex.

Presidio Pharmaceuticals, Inc. is a specialty pharmaceutical company based in San Francisco, California, dedicated to the discovery and development of small-molecule antiviral therapeutics. Founded in 2006, the company primarily focuses on creating therapies for viral infections, with a significant emphasis on hepatitis C virus (HCV) and HIV. Its product portfolio features pan-genotypic HCV NS5A inhibitors and ravidasvir hydrochloride, which target the NS5A and NS5B proteins of HCV. Presidio's antiviral therapeutics are designed for daily oral dosing and can be combined with other antiviral classes to address viral resistance, thus providing patients with effective treatment options against various hepatitis genotypes. The company has raised over $27 million from several investors to support its research and development efforts.

Vivaldi Biosciences Inc., a clinical-stage biotechnology company, develops live attenuated influenza vaccines (LAIVs) for protection against seasonal influenza and preparedness against emerging pandemic influenza. It offers deltaFLU is an advanced, self-adjuvanting influenza vaccine, administered as a nasal spray. The company was founded in 2006 and is based in Fort Collins, Colorado.

Conatus Pharmaceuticals Inc. is a biotechnology company that specializes in developing innovative therapeutics for liver diseases and chronic conditions with significant unmet medical needs. Founded in 2005 and headquartered in San Diego, California, the company has focused on its lead product candidate, Emricasan, an orally active caspase protease inhibitor currently in Phase IIb clinical trials for various liver-related conditions, including post-orthotopic liver transplant complications and liver fibrosis linked to nonalcoholic steatohepatitis. Additionally, Conatus is advancing CTS-2090, an orally active inhibitor of caspase 1, which is in the preclinical stage for treating chronic diseases associated with inflammasome pathways. The company has also entered into a collaboration agreement with Novartis to conduct three Phase IIb clinical trials. In May 2020, Conatus Pharmaceuticals was acquired by Histogen Inc. in a reverse merger transaction.

Map Pharmaceuticals, Inc. is a development-stage company based in Mountain View, California, specializing in the creation of novel inhalation therapies for respiratory and systemic diseases. Founded in 2003, the company is advancing several proprietary product candidates through clinical development. These include Unit Dose Budesonide, aimed at treating pediatric asthma in children aged six months to eight years, and MAP0004, designed for migraine relief. Additionally, Map Pharmaceuticals is developing MAP0005 for adolescent and adult asthma and chronic obstructive pulmonary disease, as well as MAP0001, which targets Type 1 and Type 2 diabetes through pulmonary delivery via its Tempo inhaler. The company's focus is on delivering innovative treatments to improve patient outcomes across various health conditions.

As of October 2010, Phenomix closed down as it was unable to find a partner to pay for is clinical trial bills after Forest Laboratories walked away. Phenomix is a drug discovery and development company building a portfolio of novel therapeutics for the treatment of major human diseases. Phenomix' lead clinical candidate, PHX1149, is a DPP4 inhibitor in phase 2 testing as a once daily oral treatment for type 2 diabetes. Phenomix' second program is directed at the treatment of hepatitis C through inhibition of the NS3/4A viral protease. Phenomix is based in San Diego, California.

PTC Therapeutics, Inc. is a biopharmaceutical company dedicated to the discovery, development, and commercialization of orally administered small-molecule therapeutics for rare disorders and oncology. Notably, it offers Translarna and Emflaza for treating nonsense mutation Duchenne muscular dystrophy in ambulatory patients. The company is advancing several clinical programs, including Translarna for nonsense mutation aniridia and Dravet syndrome/CDKL5, as well as RG7916 and RO7034067 for spinal muscular atrophy. Additionally, PTC Therapeutics is developing PTC596 and PTC299, a small molecule targeting cancer treatment, and a gene therapy candidate, PTC-AADC, for Aromatic L-amino acid decarboxylase deficiency. Collaborations with various organizations, including F. Hoffman-La Roche and the Spinal Muscular Atrophy Foundation, enhance its research and commercialization efforts. Founded in 1998, PTC Therapeutics is headquartered in South Plainfield, New Jersey.

NBI Development is an implantable medical device company focused on the development of novel neuromodulation therapies. The company develops Neuromodulation, the use of electrical impulses to manage activity in the nervous system.

Nevro Corp. is a medical device company that focuses on developing innovative solutions for patients suffering from chronic pain. Based in Redwood City, California, the company has created the Senza spinal cord stimulation (SCS) system, which is an evidence-based neuromodulation platform that includes the proprietary HF10 therapy. This therapy provides electrical impulses to alleviate pain and is controlled by patients through a remote device. Nevro's product offerings extend to the Senza II and Senza Omnia systems, which are designed for chronic pain management. The company markets its products primarily in the United States and utilizes a direct sales force, along with a network of sales agents and independent distributors, to reach its customers. Founded in 2006, Nevro aims to enhance the quality of life for individuals affected by debilitating pain through its advanced medical technologies.

NuPathe Inc. is a specialty pharmaceutical company dedicated to developing and commercializing innovative therapies for neurological and psychiatric disorders. The company's flagship product is Zecuity, a transdermal system utilizing sumatriptan for the acute treatment of migraines in adults. In addition to Zecuity, NuPathe is advancing a pipeline of product candidates, including NP201, designed for the continuous treatment of Parkinson's disease, and NP202, aimed at the long-term management of schizophrenia and bipolar disorder. Both candidates leverage the company's proprietary Long-Acting Delivery technology, which facilitates extended medication release through biodegradable implants. Founded in 2005 and based in Malvern, Pennsylvania, NuPathe operates as a subsidiary of Teva Pharmaceutical Industries Limited. The company actively seeks partnerships to enhance the commercial potential of its products in the United States and internationally.

Poniard Pharmaceuticals, Inc. is a biopharmaceutical company focused on the discovery, development and commercialization of innovative oncology products to impact the lives of people with cancer.

Map Pharmaceuticals, Inc. is a development-stage company based in Mountain View, California, specializing in the creation of novel inhalation therapies for respiratory and systemic diseases. Founded in 2003, the company is advancing several proprietary product candidates through clinical development. These include Unit Dose Budesonide, aimed at treating pediatric asthma in children aged six months to eight years, and MAP0004, designed for migraine relief. Additionally, Map Pharmaceuticals is developing MAP0005 for adolescent and adult asthma and chronic obstructive pulmonary disease, as well as MAP0001, which targets Type 1 and Type 2 diabetes through pulmonary delivery via its Tempo inhaler. The company's focus is on delivering innovative treatments to improve patient outcomes across various health conditions.

PTC Therapeutics, Inc. is a biopharmaceutical company dedicated to the discovery, development, and commercialization of orally administered small-molecule therapeutics for rare disorders and oncology. Notably, it offers Translarna and Emflaza for treating nonsense mutation Duchenne muscular dystrophy in ambulatory patients. The company is advancing several clinical programs, including Translarna for nonsense mutation aniridia and Dravet syndrome/CDKL5, as well as RG7916 and RO7034067 for spinal muscular atrophy. Additionally, PTC Therapeutics is developing PTC596 and PTC299, a small molecule targeting cancer treatment, and a gene therapy candidate, PTC-AADC, for Aromatic L-amino acid decarboxylase deficiency. Collaborations with various organizations, including F. Hoffman-La Roche and the Spinal Muscular Atrophy Foundation, enhance its research and commercialization efforts. Founded in 1998, PTC Therapeutics is headquartered in South Plainfield, New Jersey.

Radiant Medical provides medical devices intended for endovascular temperature therapy. They are a private medical device company pioneering the development of endovascular therapeutic cooling for the treatment of heart, brain, and kidney disorders. It was founded in 1999 and is headquartered in Redwood City, California.

Protez Pharmaceuticals is a medical research company that discovers, develops, and commercializes antibiotics for difficult-to-treat hospital-based infections. The company focuses on differentiated intravenous and oral small molecule antibiotics to address bacterial resistant, and chronic or recurrent infections. Protez Pharmaceuticals was founded by Christopher M. Cashman in 2003 and is headquartered in Malvern, Pennsylvania.

BrainCells develops and provides biopharmaceutical products for the treatment of central nervous system (CNS) diseases. It develops compounds that promote the growth of new neurons for the treatment of major depressive disorder (MDD), treatment resistant depression (TRD), and potentially Alzheimer’s disease (AD). The company's products include BCI-838 and BCI-632 which increase synaptic glutamate by inhibiting the mGlu2/3 auto-receptor. The company also builds a pipeline of clinical-stage programs to address unmet medical needs in the treatment of mood disorders, psychoses, cognition, brain repair syndromes, and other CNS disorders. The company was founded in 2003 and is based in San Diego, California.

As of October 2010, Phenomix closed down as it was unable to find a partner to pay for is clinical trial bills after Forest Laboratories walked away. Phenomix is a drug discovery and development company building a portfolio of novel therapeutics for the treatment of major human diseases. Phenomix' lead clinical candidate, PHX1149, is a DPP4 inhibitor in phase 2 testing as a once daily oral treatment for type 2 diabetes. Phenomix' second program is directed at the treatment of hepatitis C through inhibition of the NS3/4A viral protease. Phenomix is based in San Diego, California.

Calypso Medical Technologies, based in Seattle, is a privately held medical device company specializing in tumor localization technology. The company's proprietary system employs miniaturized implanted devices known as Beacon electromagnetic transponders to continuously and accurately track the location of tumors, enhancing the precision and management of radiation therapy delivery. This technology is particularly aimed at body-wide cancers that are commonly treated with radiation. Calypso's products have received FDA 510(k) clearance for use in the prostate and post-operative prostatic bed, ensuring compliance with regulatory standards. The company has established strategic partnerships with leading organizations in the medical field, including Varian Medical Systems, Siemens Medical Systems, Elekta Corporation, and Philips Medical, to further its mission of improving cancer treatment outcomes.

CymaBay Therapeutics is a clinical-stage biopharmaceutical company based in Newark, California, dedicated to developing therapies for liver and other chronic diseases with significant unmet medical needs. The company's lead product candidate, seladelpar, is a selective agonist of the peroxisome proliferator-activated receptor delta, which has completed Phase II clinical studies targeting conditions such as primary biliary cholangitis and sclerosing cholangitis, as well as nonalcoholic steatohepatitis. Additionally, CymaBay is developing MBX-2982, a selective oral G protein-coupled receptor agonist aimed at treating gut and liver diseases. The company also has a preclinical candidate, CB-001, which targets omega-3 fatty acid receptors. CymaBay has entered into development and licensing agreements with other pharmaceutical firms to explore treatments for metabolic diseases, including type 2 diabetes and gout. The company's commitment to advancing its pipeline reflects its focus on creating innovative medicines that can improve patient outcomes.

Map Pharmaceuticals, Inc. is a development-stage company based in Mountain View, California, specializing in the creation of novel inhalation therapies for respiratory and systemic diseases. Founded in 2003, the company is advancing several proprietary product candidates through clinical development. These include Unit Dose Budesonide, aimed at treating pediatric asthma in children aged six months to eight years, and MAP0004, designed for migraine relief. Additionally, Map Pharmaceuticals is developing MAP0005 for adolescent and adult asthma and chronic obstructive pulmonary disease, as well as MAP0001, which targets Type 1 and Type 2 diabetes through pulmonary delivery via its Tempo inhaler. The company's focus is on delivering innovative treatments to improve patient outcomes across various health conditions.

Avera Pharmaceuticals is a specialty pharmaceutical company that acquires, develops, and commercializes pharmaceutical compounds. The company develops gantacurium, a neuromuscular blocking agent for rapid and routine endotracheal intubation and skeletal muscle relaxation during surgery; AV810 for the treatment of overactive bladder and irritable bowel syndrome; and AV965 to treat cognitive impairment associated with schizophrenia and Alzheimer’s dementia. The company was founded in 2002 and is headquartered in San Diego, California.

As of October 2010, Phenomix closed down as it was unable to find a partner to pay for is clinical trial bills after Forest Laboratories walked away. Phenomix is a drug discovery and development company building a portfolio of novel therapeutics for the treatment of major human diseases. Phenomix' lead clinical candidate, PHX1149, is a DPP4 inhibitor in phase 2 testing as a once daily oral treatment for type 2 diabetes. Phenomix' second program is directed at the treatment of hepatitis C through inhibition of the NS3/4A viral protease. Phenomix is based in San Diego, California.

EnteroMedics® Inc. is the developer of vBloc® neurometabolic therapy, delivered by a pacemaker-like device called the Maestro® Rechargeable System, a first-in-class weight loss treatment for obesity and obesity related risk factors, such as high blood pressure or high cholesterol levels. vBloc Therapy is a non-anatomy altering or restricting, reversible therapy that allows patients to safely lose weight by helping patients feel less hungry, reduce the amount of food eaten at a meal, and feel full longer in between meals.

PTC Therapeutics, Inc. is a biopharmaceutical company dedicated to the discovery, development, and commercialization of orally administered small-molecule therapeutics for rare disorders and oncology. Notably, it offers Translarna and Emflaza for treating nonsense mutation Duchenne muscular dystrophy in ambulatory patients. The company is advancing several clinical programs, including Translarna for nonsense mutation aniridia and Dravet syndrome/CDKL5, as well as RG7916 and RO7034067 for spinal muscular atrophy. Additionally, PTC Therapeutics is developing PTC596 and PTC299, a small molecule targeting cancer treatment, and a gene therapy candidate, PTC-AADC, for Aromatic L-amino acid decarboxylase deficiency. Collaborations with various organizations, including F. Hoffman-La Roche and the Spinal Muscular Atrophy Foundation, enhance its research and commercialization efforts. Founded in 1998, PTC Therapeutics is headquartered in South Plainfield, New Jersey.

PTC Therapeutics, Inc. is a biopharmaceutical company dedicated to the discovery, development, and commercialization of orally administered small-molecule therapeutics for rare disorders and oncology. Notably, it offers Translarna and Emflaza for treating nonsense mutation Duchenne muscular dystrophy in ambulatory patients. The company is advancing several clinical programs, including Translarna for nonsense mutation aniridia and Dravet syndrome/CDKL5, as well as RG7916 and RO7034067 for spinal muscular atrophy. Additionally, PTC Therapeutics is developing PTC596 and PTC299, a small molecule targeting cancer treatment, and a gene therapy candidate, PTC-AADC, for Aromatic L-amino acid decarboxylase deficiency. Collaborations with various organizations, including F. Hoffman-La Roche and the Spinal Muscular Atrophy Foundation, enhance its research and commercialization efforts. Founded in 1998, PTC Therapeutics is headquartered in South Plainfield, New Jersey.

Avera Pharmaceuticals is a specialty pharmaceutical company that acquires, develops, and commercializes pharmaceutical compounds. The company develops gantacurium, a neuromuscular blocking agent for rapid and routine endotracheal intubation and skeletal muscle relaxation during surgery; AV810 for the treatment of overactive bladder and irritable bowel syndrome; and AV965 to treat cognitive impairment associated with schizophrenia and Alzheimer’s dementia. The company was founded in 2002 and is headquartered in San Diego, California.