BlueTree Allied Angels

CytoAgents, Inc. is a clinical-stage biotechnology company based in Pittsburgh, Pennsylvania, established in 2018. The company specializes in developing innovative protein-based drugs aimed at treating viral infectious diseases, particularly focusing on life-threatening symptoms associated with Cytokine Release Syndrome (CRS). CRS is an inflammatory response characterized by an overactive immune system, often linked to conditions such as oncology CAR-T cell therapy and COVID-19. CytoAgents' lead product, GP1681, acts as an agonist of a G-protein coupled receptor and represents a novel therapeutic approach to manage the immune response in patients experiencing cytokine storms. Through its research and development efforts, CytoAgents aims to address significant unmet medical needs across various indications, enhancing treatment efficacy for patients suffering from severe systemic inflammation.

Erin is a developer of a smart employee referral platform that enhances employee referral programs, aiming to deliver higher-quality candidates with longer tenures at a reduced cost compared to traditional recruitment methods. Established in 2018 and based in Pittsburgh, Pennsylvania, Erin's platform automates the referral process by notifying employees of new job openings and enabling them to make referrals, while also tracking referral bonuses. This system alleviates the administrative burden associated with managing employee referrals, ensuring that both employees and administrators are kept informed through automated email and mobile notifications.

OndeCare is a premium in-home care marketplace that provides a platform for clients to book high-quality care services tailored to various ages and needs. The company emphasizes concierge-level support, allowing users to connect with professional caregivers quickly and efficiently. OndeCare's model not only enables families to access reliable in-home care but also creates valuable job opportunities for local care, safety, and education professionals. By maintaining competitive pricing comparable to traditional home care, OndeCare fulfills the caregiving needs of families while enhancing the overall quality of care available in the marketplace. Additionally, the company offers an employee benefit SaaS solution that provides full visibility into return on investment for organizations.

C360 Technologies, Inc., established in 2008 and based in Wexford, Pennsylvania, specializes in manufacturing innovative video products for broadcast and over-the-top (OTT) platforms. The company offers non-stitched immersive video solutions, including cameras and workstations, that directly connect with broadcasters' backhaul systems, providing multiple live HD-SDI outputs and enhanced replay systems for real-time broadcast production. C360's products enable simultaneous live television broadcasts and OTT streaming, empowering users with independent control of camera location and functions during live events.

Augment Therapy, Inc. is a Cleveland-based company that specializes in developing an interactive augmented reality telemedicine software solution specifically designed for pediatric physical therapy. Founded in 2017, the company creates a platform that engages children in rehabilitative exercises through gamified technology, enhancing their motivation and participation. The software incorporates depth-sensing camera technology and offers a library of evidence-based exercises and interactive games, enabling real-time, remote monitoring of therapy sessions. This innovative approach allows therapists to automate data collection and analyze objective patient data, thereby improving the overall effectiveness of pediatric rehabilitation.

OndeCare is a premium in-home care marketplace that provides a platform for clients to book high-quality care services tailored to various ages and needs. The company emphasizes concierge-level support, allowing users to connect with professional caregivers quickly and efficiently. OndeCare's model not only enables families to access reliable in-home care but also creates valuable job opportunities for local care, safety, and education professionals. By maintaining competitive pricing comparable to traditional home care, OndeCare fulfills the caregiving needs of families while enhancing the overall quality of care available in the marketplace. Additionally, the company offers an employee benefit SaaS solution that provides full visibility into return on investment for organizations.

Edge Case Research is a company based in Pittsburgh, Pennsylvania, with an additional office in Unterschleißheim, Germany, specializing in developing software products and safety systems for companies involved in self-driving car technology. Founded in 2013, the firm focuses on testing vehicle software and artificial intelligence without requiring physical vehicles. Its key offerings include Hologram, a platform for identifying and addressing edge cases that challenge machine learning, and Switchboard, a cloud-based tool for automated robustness testing of complex software. The company employs Model-based Iterative System Safety Analysis to pinpoint and model safety risks in intricate systems. Additionally, Edge Case Research provides embedded software best practices assessment and training services. It serves industries such as autonomous vehicles and robotics, consumer electronics and the Internet of Things, and industrial controls and embedded systems.

Gridwise, Inc. is a technology company based in Pittsburgh, Pennsylvania, that specializes in developing a mobile application designed for rideshare and delivery drivers. Founded in 2016, Gridwise offers a comprehensive platform that assists gig economy drivers in maximizing their earnings and enhancing their business operations. The application provides real-time insights on passenger demand, traffic, and weather, as well as alerts for nearby opportunities. Additionally, it features tools for tracking mileage, calculating tax deductions, and generating detailed tax reports. With its focus on performance tracking and earnings analysis, Gridwise empowers hundreds of thousands of drivers across the United States to effectively manage their gig work.

Lindy Biosciences is a development-stage company based in Durham, North Carolina, focused on producing protein-based therapeutic formulations. The company utilizes Microglassification technology, which gently removes most of the water from solutions of proteins or other biologics, creating solid, spherical, amorphous microbeads. These particles are stable and dense, making them suitable for various applications such as high-concentration suspensions, encapsulation for controlled release, and dry powder pulmonary delivery. Lindy Biosciences was incorporated in 2016 and specializes in formulations that enhance the long-term storage and delivery of protein therapeutics.

Edge Case Research is a company based in Pittsburgh, Pennsylvania, with an additional office in Unterschleißheim, Germany, specializing in developing software products and safety systems for companies involved in self-driving car technology. Founded in 2013, the firm focuses on testing vehicle software and artificial intelligence without requiring physical vehicles. Its key offerings include Hologram, a platform for identifying and addressing edge cases that challenge machine learning, and Switchboard, a cloud-based tool for automated robustness testing of complex software. The company employs Model-based Iterative System Safety Analysis to pinpoint and model safety risks in intricate systems. Additionally, Edge Case Research provides embedded software best practices assessment and training services. It serves industries such as autonomous vehicles and robotics, consumer electronics and the Internet of Things, and industrial controls and embedded systems.

Aeronics is a technology company specializing in innovative oxygen storage solutions. The company has developed a low-weight portable oxygen device that utilizes porous materials to efficiently absorb and store oxygen, similar to how a sponge absorbs water. This technology significantly increases the amount of oxygen that can be stored in a given volume, making their devices lightweight and portable. Aeronics offers two main product lines: Everyday Oxygen and Pawprint Oxygen, both designed for medical, recreational, and defense applications. Their FDA-approved device was launched in 2020.

BoardBookit, Inc. is a software company that specializes in developing board portal solutions for organizations and their boards of directors. Founded in 2012 and headquartered in Pittsburgh, Pennsylvania, BoardBookit offers a platform designed to streamline the planning, creation, and management of board meetings, enhancing communication and decision-making processes. The platform provides secure tools that facilitate information sharing, ensuring an efficient experience for both companies and board members. BoardBookit serves a diverse clientele across the United States, Canada, Europe, and Australia, focusing on empowering organizations to improve their boardroom operations.

Cocomama is a women-owned business specializing in the production of fair trade and fully traceable hot cocoa and baking mixes. The company crafts organic cocoa products, cocoa powders, and brownie thins, which are used to produce cakes, pastries, and cookies. Cocomama sources its ingredients from countries such as the Dominican Republic, Madagascar, and Indonesia, ensuring that customers receive high-quality, delicious chocolate products.

PittMoss LLC is a manufacturer based in Ambridge, Pennsylvania, specializing in sustainable gardening solutions. The company produces PittMoss, a peat-free potting mixture made from organic additives and recycled paper fibers, which are designed to serve both commercial greenhouses and nurseries, as well as home gardeners across the United States. PittMoss is developed as a substitute for traditional sphagnum peat moss, providing an environmentally friendly alternative that helps reduce landfill waste. Additionally, the company offers PittMoss Prime, a versatile soil amendment that can be combined with compost, existing soil blends, or native soil to enhance plant growth. Founded in 1994, PittMoss emphasizes innovation through its research into recycling paper materials for horticultural use.

C360 Technologies, Inc., established in 2008 and based in Wexford, Pennsylvania, specializes in manufacturing innovative video products for broadcast and over-the-top (OTT) platforms. The company offers non-stitched immersive video solutions, including cameras and workstations, that directly connect with broadcasters' backhaul systems, providing multiple live HD-SDI outputs and enhanced replay systems for real-time broadcast production. C360's products enable simultaneous live television broadcasts and OTT streaming, empowering users with independent control of camera location and functions during live events.

Carmell was founded in 2007 to commercialize technology developed jointly at Carnegie Mellon University and Allegheny General Hospital. The proprietary technology enables the manufacture of biologically-active plastics from blood plasma for treating injuries to bone and connective tissue. These plastics are sterile, off-the-shelf, easy to handle, shape and suture, have controlled degradation rates, contain known levels of bioactivity, and exhibit mechanical properties designed to match the repaired tissue. Carmell's plastics can be simply viewed as plastic forms of ultra-concentrated blood clots; they therefore represent the ideal biomaterials, using the body's own growth and regenerative factors to naturally promote tissue healing. The Company is focused on the sports medicine market, with products designed to accelerate healing and produce better clinical outcomes in treating injuries to connective tissue (e.g., tendons, ligaments and cartilage).

Zive Inc., established in 2013 and based in New York, specializes in consumer software development. Its flagship product, Kiwi for Gmail, is a desktop application for Mac and Windows users that enhances Google Workspace's functionality, transforming it into a suite of desktop apps with improved business integration and productivity features. Kiwi for Gmail, currently at version 2.0 with a new toolbar and multitasking capabilities, serves over 600 enterprise and SMB companies worldwide using Google Workspace. Zive is actively developing additional productivity applications tailored to enterprise users.

Anglr is a company that operates within the sportfishing industry, leveraging technology to enhance the fishing experience. It offers a comprehensive fishing application that serves as a digital logbook, allowing anglers to track and record vital details of their fishing adventures, such as cast locations, bait used, weather conditions, and the number of catches. Alongside this application, Anglr provides a suite of connected Internet of Things devices that complement the app, creating a seamless ecosystem for users. This platform not only enables anglers to document their fishing stats and memories but also fosters a social network where they can share experiences, compare results, and prepare for future outings. Overall, Anglr aims to enrich the enjoyment of fishing by combining technology with the tradition of the sport.

RendrFX, founded in 2015 and headquartered in Erie, Pennsylvania, is a software company specializing in mobile-first video creation solutions. Its platform connects businesses and individuals with global communities of motion graphics artists, enabling users to create professional, affordable videos through an online plug-and-play system. This model benefits both end-users seeking high-definition videos with ease and affordability, and motion graphics artists looking for fair opportunities to sell their work.

Cognition Therapeutics, Inc. is a clinical-stage neuroscience company based in Pittsburgh, Pennsylvania, focused on developing small-molecule therapeutics for neurodegenerative and neuro-ophthalmic disorders. Founded in 2007, the company aims to restore normal cellular damage responses by targeting toxic proteins that contribute to cognitive decline, particularly in conditions such as Alzheimer's disease and dry age-related macular degeneration. Its lead product candidate, CT1812, is an orally administered drug designed to penetrate the blood-brain barrier and selectively bind to the S2R complex. Through its expertise in biological research and proprietary medicinal chemistry, Cognition Therapeutics is dedicated to creating innovative drug candidates that address significant unmet medical needs in the treatment of degenerative diseases.

PittMoss LLC is a manufacturer based in Ambridge, Pennsylvania, specializing in sustainable gardening solutions. The company produces PittMoss, a peat-free potting mixture made from organic additives and recycled paper fibers, which are designed to serve both commercial greenhouses and nurseries, as well as home gardeners across the United States. PittMoss is developed as a substitute for traditional sphagnum peat moss, providing an environmentally friendly alternative that helps reduce landfill waste. Additionally, the company offers PittMoss Prime, a versatile soil amendment that can be combined with compost, existing soil blends, or native soil to enhance plant growth. Founded in 1994, PittMoss emphasizes innovation through its research into recycling paper materials for horticultural use.

Rinovum Women's Health, Inc. develops medical devices for women. It offers Stork, a medical device that aids in natural fertility and conception in the privacy of home.

Wombat Security Technologies, Inc. specializes in interactive software solutions aimed at enhancing cyber security awareness and compliance among employees. The company offers a comprehensive Security Education Platform that includes knowledge assessments, a library of simulated attacks, and interactive training modules designed to significantly reduce the success rate of phishing attacks and malware infections. Key products include PhishPatrol, an anti-phishing email filter; PhishAlarm Analyzer, which assists in identifying reported phishing emails; CyberStrength, an assessment tool for evaluating employee cyber security knowledge; and various simulation services such as USBGuru and SmishGuru that train employees on memory device and text message phishing attacks respectively. Wombat serves a diverse clientele, including Fortune 1000 companies in sectors such as finance, healthcare, and technology. Founded in 2008 and based in Pittsburgh, Pennsylvania, with an additional office in the United Kingdom, Wombat operates as a subsidiary of Proofpoint, Inc.

Carmell was founded in 2007 to commercialize technology developed jointly at Carnegie Mellon University and Allegheny General Hospital. The proprietary technology enables the manufacture of biologically-active plastics from blood plasma for treating injuries to bone and connective tissue. These plastics are sterile, off-the-shelf, easy to handle, shape and suture, have controlled degradation rates, contain known levels of bioactivity, and exhibit mechanical properties designed to match the repaired tissue. Carmell's plastics can be simply viewed as plastic forms of ultra-concentrated blood clots; they therefore represent the ideal biomaterials, using the body's own growth and regenerative factors to naturally promote tissue healing. The Company is focused on the sports medicine market, with products designed to accelerate healing and produce better clinical outcomes in treating injuries to connective tissue (e.g., tendons, ligaments and cartilage).

Gemmus Pharma Inc., established in 2007 and headquartered in San Francisco, California, is a biotechnology company focused on developing therapeutics for the treatment of influenza and other infectious diseases. The company's primary product candidates are GP1001 and GP1681. GP1001, a non-peptidic eiconsanoid analog, is intended for treating severe influenza infections requiring hospitalization, serving as either a standalone therapy or in combination with antiviral drugs like oseltamivir. Meanwhile, GP1681 aims to alleviate influenza symptoms by moderating the viral-induced cytokine response. Gemmus Pharma has received support from the National Institute of Allergy and Infectious Diseases (NIAID) and plans to submit an Investigational New Drug (IND) application to the FDA for its influenza treatment in 2014.

Neuros Medical, Inc. is a neuromodulation company dedicated to developing innovative therapies to address unmet medical needs for patients globally. Founded in 2008 and headquartered in Willoughby Hills, Ohio, the company specializes in its proprietary platform technology known as Electrical Nerve Block. This technology is designed to eliminate chronic pain across various conditions, including neuroma/residual limb pain, chronic post-surgical pain, and chronic migraine. The Neuros Altius System, one of its key products, includes an implantable generator with an integrated rechargeable battery, a cuff electrode, and external devices, further demonstrating the company's commitment to advancing pain management solutions.

ALung Technologies, Inc., established in 1997 and based in Pittsburgh, Pennsylvania, specializes in developing and manufacturing medical devices for treating acute respiratory failure. The company's primary product is the Hemolung Respiratory Assist System, a dialysis-like device that removes carbon dioxide and delivers oxygen directly to the blood, allowing patients' lungs to rest and heal while avoiding intubation and facilitating protective ventilation.

Physcient, Inc. is a medical device company based in Durham, North Carolina, established in 2007. The company specializes in the manufacturing of the Differential Dissector, a surgical instrument designed for blunt dissection. This device is utilized in a variety of surgical fields, including plastic surgery and open general surgical procedures such as thoracic, gastrointestinal, gynecological, urological, peripheral vascular, and orthopedic surgeries. Physcient focuses on developing modern technology for handheld surgical instruments that aim to facilitate faster patient recovery while maintaining existing surgical procedures. The founding team comprises three scientists and executives with extensive experience in innovating technologies for the life and health sciences.

Cryothermic Systems, previously known as Life Core Technologies, is an American medical device company focused on developing innovative products to enhance patient outcomes by preventing brain damage. The company’s flagship product, Excel Cryo, is designed to lower brain temperature immediately following neurological injuries. This device operates without the need for electrical power, refrigeration, or external equipment, making it suitable for use in emergency medical services or intensive care units. The Excel Cryo is integrated into a cooling collar that holds a cooling pack in place, effectively extracting heat from the neck's blood vessels. This technology aims to assist healthcare providers in managing patients suffering from ischemic and reperfusion injuries related to conditions such as cardiac arrest, heart attack, stroke, and traumatic brain injury, thereby improving overall patient care and recovery outcomes.

Cryothermic Systems, previously known as Life Core Technologies, is an American medical device company focused on developing innovative products to enhance patient outcomes by preventing brain damage. The company’s flagship product, Excel Cryo, is designed to lower brain temperature immediately following neurological injuries. This device operates without the need for electrical power, refrigeration, or external equipment, making it suitable for use in emergency medical services or intensive care units. The Excel Cryo is integrated into a cooling collar that holds a cooling pack in place, effectively extracting heat from the neck's blood vessels. This technology aims to assist healthcare providers in managing patients suffering from ischemic and reperfusion injuries related to conditions such as cardiac arrest, heart attack, stroke, and traumatic brain injury, thereby improving overall patient care and recovery outcomes.

Gemmus Pharma Inc., established in 2007 and headquartered in San Francisco, California, is a biotechnology company focused on developing therapeutics for the treatment of influenza and other infectious diseases. The company's primary product candidates are GP1001 and GP1681. GP1001, a non-peptidic eiconsanoid analog, is intended for treating severe influenza infections requiring hospitalization, serving as either a standalone therapy or in combination with antiviral drugs like oseltamivir. Meanwhile, GP1681 aims to alleviate influenza symptoms by moderating the viral-induced cytokine response. Gemmus Pharma has received support from the National Institute of Allergy and Infectious Diseases (NIAID) and plans to submit an Investigational New Drug (IND) application to the FDA for its influenza treatment in 2014.

Voci is a technology company specializing in advanced speech recognition solutions that transform voice data into actionable insights. Utilizing hardware-accelerated speech recognition and artificial intelligence, Voci provides businesses with highly accurate transcriptions and valuable analytics, including insights on gender, sentiment, emotion, and speaker biometrics. The company's services are particularly beneficial for organizations in highly regulated sectors, as they help ensure compliance and mitigate risks related to fraud and regulatory violations. Additionally, Voci offers automatic speech-to-text services that enhance voicemail outputs for telecommunications providers, contributing to improved customer experience and optimized contact center operations. Through its innovative approach, Voci empowers companies to analyze audio data effectively, track call center performance, and gain a deeper understanding of customer interactions.

Carmell was founded in 2007 to commercialize technology developed jointly at Carnegie Mellon University and Allegheny General Hospital. The proprietary technology enables the manufacture of biologically-active plastics from blood plasma for treating injuries to bone and connective tissue. These plastics are sterile, off-the-shelf, easy to handle, shape and suture, have controlled degradation rates, contain known levels of bioactivity, and exhibit mechanical properties designed to match the repaired tissue. Carmell's plastics can be simply viewed as plastic forms of ultra-concentrated blood clots; they therefore represent the ideal biomaterials, using the body's own growth and regenerative factors to naturally promote tissue healing. The Company is focused on the sports medicine market, with products designed to accelerate healing and produce better clinical outcomes in treating injuries to connective tissue (e.g., tendons, ligaments and cartilage).

Voci is a technology company specializing in advanced speech recognition solutions that transform voice data into actionable insights. Utilizing hardware-accelerated speech recognition and artificial intelligence, Voci provides businesses with highly accurate transcriptions and valuable analytics, including insights on gender, sentiment, emotion, and speaker biometrics. The company's services are particularly beneficial for organizations in highly regulated sectors, as they help ensure compliance and mitigate risks related to fraud and regulatory violations. Additionally, Voci offers automatic speech-to-text services that enhance voicemail outputs for telecommunications providers, contributing to improved customer experience and optimized contact center operations. Through its innovative approach, Voci empowers companies to analyze audio data effectively, track call center performance, and gain a deeper understanding of customer interactions.

DiaKine Therapeutics, Inc. is a development stage company focused on commercializing innovative immune modulators aimed at treating diabetes and its associated complications. The company's therapeutics possess unique immune-modulating and anti-inflammatory properties, which may not only halt the progression of diabetes but also reverse existing damage caused by the disease. Current products in development include adjunct therapies for islet cell transplants undergoing Phase 2 clinical trials, as well as treatments designed to stop the progression of type 1 diabetes in newly diagnosed adults. Additionally, DiaKine is exploring therapies for Latent Autoimmune Diabetes in Adults (LADA) and insulin-requiring type 2 diabetes, alongside interventions to prevent diabetes-related complications. The company acknowledges the support of the National Institute of Diabetes & Digestive & Kidney Diseases for providing clinical trial supplies.

TalkShoe, Inc. is a company that operates a platform for user-generated live and recorded audio content, primarily focusing on facilitating conversations and discussions among users worldwide. Founded in 2005 and based in Wexford, Pennsylvania, TalkShoe allows individuals to create and participate in live group calls, interactive podcasts, and audio blogs on a wide range of topics, including business, sports, politics, and science. The platform enables voice and text chat, connecting users with similar interests. TalkShoe supports nearly 100,000 users, with millions more accessing recorded content through various podcast directories. The service is designed for talkers, listeners, bloggers, and podcasters, and it can be integrated with social networks to enhance the sharing and promotion of audio content. As of May 2016, TalkShoe operates as a subsidiary of iotum inc.

StageMark develops and markets inflammatory diseases identification and monitoring solutions. The company's product, CB-CAPs, enables user to analyze complement products bound to various blood cell types such as erythrocytes, platelets, reticulocytes, and lymphocytes. StageMark, Inc. was founded in 2004 and is headquartered in Pittsburgh, Pennsylvania.

The SilentAlert Resident Attendant System is a product of NewCare Solutions, LLC. Located in the Pittsburgh metropolitan area, NewCare Solutions is a spinoff of medSage Technologies, LLC and was created when its founder, William Kaigler, was unable to find an effective and affordable solution to help his 85-year old mother live independently in her home. The SilentAlert Resident Attendant System became a reality after his mother was hospitalized and her sleep was continuously disrupted by an audible bed alarm for another patient.