BoxOne Ventures

Stately Bio specializes in regenerative medicine technologies for therapeutic discovery and manufacturing. Its patented machine learning-based live-cell imaging system measures cell identity, behavior, and maturation directly from live cells without labels or dyes, facilitating non-invasive, real-time analysis of living cells.

Dispersa develops eco-friendly biosurfactants, made from food waste rather than food-grade sources. These palm- and petroleum-free surfactants aim to improve the sustainability and affordability of the biosurfactant market.

CytoTronics is focused on designing and developing advanced cell culture plates that incorporate embedded high-density electronic systems. This innovative technology enables researchers to visualize live cell functions on a large scale and obtain real-time data on cell behavior. By facilitating detailed studies of complex biological processes, CytoTronics aims to support significant advancements in fields such as drug discovery and personalized medicine. The company's semiconductor-based systems provide a valuable tool for researchers, enhancing their ability to investigate cellular dynamics and improve the understanding of cellular interactions.

Talus Bio is a biotechnology company specializing in drug discovery. It focuses on developing therapies targeting challenging cancer transcription factors using its proprietary MARMOT platform, which integrates functional proteomics, automated biology, machine learning, AI, synthetic chemistry, and computational biology to design and analyze drugs, proteins, and genomics.

Opalia develops milk and milk ingredients produced from mammary cells, offering a cow-free alternative to traditional dairy. Using mammary cells cultured in bioreactors, the company produces milk with the same nutritional profile and taste as conventional milk while eliminating the need for cows. The approach aims to reduce environmental impact and provide sustainable, ethical dairy options for consumers.

Pathway is a health technology company focused on enhancing access to essential medical information for clinicians and patients during the care journey. The company develops a point-of-care reference tool that provides rapid access to evidence-based clinical guidelines. By organizing and condensing medical literature, Pathway aims to make critical information more accessible and easier to understand for healthcare professionals. This approach enables clinicians to work more efficiently, ultimately improving patient outcomes. Leveraging artificial intelligence and big data, Pathway creates a medical knowledge graph and software solutions that integrate evidence-based medicine into clinical practice.

BioLoomics is a biotechnology company that specializes in improving drug discovery and delivery. Founded in 2019, it offers drug screening services using biosensors to analyze drug action and toxicity in live cells. The company also develops tools for enhancing drug discovery efficiency and engineers proteins and cells for drug effect sensing with imaging technology.

Vivid Machines is a startup that builds a precision crop management platform for fruit and vegetable producers. The system combines advanced vision sensors, multispectral imaging, and machine learning to deliver real‑time analytics. It quantifies fruit size distribution, detects pests and diseases, and assesses plant health, enabling growers to digitize the physical and chemical attributes of their fields. By providing plant‑specific insights and predictive tools, the platform helps farmers optimize resource use, improve yield and product quality, and increase the proportion of crops that reach grocery stores.

Nimble Science Ltd. is a digital health company focused on revolutionizing gastrointestinal (GI) health through its innovative SIMBA capsule technology. This end-to-end platform facilitates multi-omic mapping of the GI tract, allowing for the passive sampling of small bowel luminal fluid. By leveraging this advanced sampling method, Nimble Science provides precision datasets that offer valuable insights into GI health, thereby transforming the diagnosis and treatment of gastrointestinal conditions. The company's approach enables healthcare providers to directly sample and analyze targeted regions of the GI tract, marking a significant advancement in the understanding and management of GI health.

Magnestar develops a platform monitoring space signal communications. It simulates interference scenarios, facilitates collaborative coordination, and enables real-time analysis for satellite and Earth system operators.

Founded in 2014, Odd Burger specializes in producing plant-based, less processed foods using automation and large-scale production. Initially operating as Globally Local, the company aimed to provide affordable access to plant-based foods for improved health, environmental protection, and animal welfare.

Seqera develops workflow orchestration software for life sciences research. Its open-source platform simplifies complex data analysis pipelines, enabling scientists to conduct research faster on larger datasets across multi-cloud environments.

Wayfinder Biosciences is a biotechnology company focused on developing orally available small molecule drugs that modulate RNA targets linked to cancer and neurodegenerative diseases. The company uses a proprietary platform that combines high-throughput screening, computational modeling, and machine learning with unique datasets to discover RNA-targeting compounds with potency and selectivity for traditionally inaccessible targets. Its approach includes RNA biosensor technologies that render target molecules detectable, aiding discovery and evaluation. Founded in 2021 and based in Seattle, Wayfinder aims to accelerate development of therapies for undruggable targets by enabling rapid screening and optimization of RNA-targeting small molecules.

Covey is an analyst-led community focused on identifying and rewarding emerging talent in money management. The company has developed a financial platform that facilitates the creation and sharing of portfolios among users. This platform allows analysts to share portfolio analytics across various communities while aggregating trade-level data on equities. By providing a sophisticated mock portfolio trading suite, Covey assists hedge funds and investment institutions in refining their trading strategies, ultimately enhancing their investment decision-making processes.

Spiderwort is an innovative company based in Ottawa, Ontario, founded in 2015, focused on developing biomaterials for regenerative medicine. The company specializes in creating cellulose-based biomaterials that serve as living scaffolds, which can be utilized for various medical applications, including spinal cord injury repair and soft tissue regeneration. Spiderwort's products encompass a range of biological and synthetic polymers available in multiple forms, such as powders, gels, membranes, and pastes. Currently in the pre-clinical stage, their novel biomaterials have shown promising results in terms of biocompatibility and the ability to induce angiogenesis, which is the generation of blood vessels within the scaffold. This approach aims to advance the repair and regeneration of tissues within the human body, providing new solutions for challenging medical conditions.

Unravel Biosciences is a therapeutics company spun out from the Wyss Institute at Harvard University. It develops therapies for complex disorders by repurposing existing drugs to discover and clinically validate new targets. The company combines a proprietary large action model of human health with rapid in vivo screening and clinical validation to uncover drug targets and derisk novel biology faster and more cost-effectively than traditional approaches. Its platform integrates computational drug prediction with on-demand animal models and screening tools to link behavioral and cognitive symptoms to targets and treatments. The business has progressed discoveries into several clinical trials and has built partnerships through its rareSHIFT services to expand its therapeutic pipeline, intellectual property, and access to clinical samples.

Isabl is a startup focused on developing advanced diagnostic assays for cancer through whole-genome and RNA sequencing. Founded in 2020 after incubating its technology at Memorial Sloan Kettering Cancer Center from 2015 to 2019, Isabl participated in the Winter 2020 batch of Y Combinator and has attracted significant funding, including a $3 million seed round and a $2 million SBIR grant from the National Cancer Institute. The company received FDA Breakthrough Device designation in 2021, recognizing the innovative nature of its cancer diagnostic tests. Isabl's platform is designed to efficiently analyze cancer patients' genomes while ensuring data reproducibility and supporting bioinformatics operations, thereby facilitating data-driven automation for oncology centers. Led by founders Dr. Elli Papaemmanuil, Dr. Andrew Kung, and Juan Medina, Isabl's team combines expertise in precision medicine, computational biology, and software engineering, focusing on biomarker discovery and clinical decision support for pediatric and rare solid cancers.

SX Network operates a blockchain-based sports betting exchange, offering bettors improved odds, transparency, and secure fund management through smart contract technology. Its platform integrates an on-chain community treasury and native prediction market protocol, facilitating decentralized sports betting markets governed by users via prediction market-based governance.

DrugBank is a leading provider of pharmaceutical knowledge databases. It offers an extensive suite of products powered by the world's most comprehensive and up-to-date drug information. The company enables businesses to enhance healthcare delivery through precision medicine and clinical software applications, while also facilitating drug discovery through data science. DrugBank's structured datasets are used for uncovering novel drug candidates, identifying repurposing opportunities, and building predictive machine learning models. Additionally, DrugBank Online, a publicly available resource, offers limited datasets for academic and non-commercial researchers.

Shakepay Inc. is a Montreal-based technology company that specializes in financial applications aimed at helping users build wealth through cryptocurrency. Founded in 2015, Shakepay offers a platform that allows Canadians to buy and sell Bitcoin, as well as a peer-to-peer mobile wallet for secure transactions. The company's services include a VISA debit card that enables users to load and spend Bitcoin for various purposes, including point of sale transactions, ATM withdrawals, and online purchases. By providing these innovative financial tools, Shakepay aims to facilitate the use of digital currencies in everyday transactions.

TriplePlay is a Toronto-based company founded in 2020 that offers a virtual social network designed to facilitate connections among users through interactive gaming and video-based communication. The platform allows individuals to engage in one-on-one or group conversations, participate in workshops, panel discussions, and live demonstrations, as well as enjoy games together. With features that support private conversations and customization options, TriplePlay aims to create a more natural and engaging social experience for its users.

Coinmiles is a developer of an advanced Bitcoin-based reward application that offers users cashback in the form of Bitcoin when shopping online or in-store at over 1,000 brands, as well as when traveling at more than 900,000 hotels worldwide. The platform aims to create a comprehensive ecosystem that not only rewards consumers but also assists brands in managing and advertising their loyalty programs. By facilitating partnerships between users and brands, Coinmiles enhances user acquisition and engagement, allowing shoppers to convert their Bitcoin rewards into cash as needed. The company continues to innovate and expand its offerings within the cryptocurrency reward space.

Pathway is a health technology company focused on enhancing access to essential medical information for clinicians and patients during the care journey. The company develops a point-of-care reference tool that provides rapid access to evidence-based clinical guidelines. By organizing and condensing medical literature, Pathway aims to make critical information more accessible and easier to understand for healthcare professionals. This approach enables clinicians to work more efficiently, ultimately improving patient outcomes. Leveraging artificial intelligence and big data, Pathway creates a medical knowledge graph and software solutions that integrate evidence-based medicine into clinical practice.

Seqera develops workflow orchestration software for life sciences research. Its open-source platform simplifies complex data analysis pipelines, enabling scientists to conduct research faster on larger datasets across multi-cloud environments.

Colabra develops data integration and collaboration tools for scientific teams, enabling real-time collaboration, integration of all data, and agile project management. Its platform helps scientists track workflows, gather and share feedback, and publish data and outcomes, supporting research and development efforts by eliminating inefficiencies, boosting research efficiency, and fostering more innovative work.

Vivid Machines is a startup that builds a precision crop management platform for fruit and vegetable producers. The system combines advanced vision sensors, multispectral imaging, and machine learning to deliver real‑time analytics. It quantifies fruit size distribution, detects pests and diseases, and assesses plant health, enabling growers to digitize the physical and chemical attributes of their fields. By providing plant‑specific insights and predictive tools, the platform helps farmers optimize resource use, improve yield and product quality, and increase the proportion of crops that reach grocery stores.

Revelio Labs specializes in workforce analytics. It uses AI technologies to analyze hundreds of millions of online profiles, resumes, and job postings globally, providing valuable insights for corporate strategists, HR teams, VCs, and investors.

Axonis Therapeutics is a biotechnology company focused on neurological disorders. It develops medicines targeting KCC2, a critical mediator of inhibition within the brain, using a proprietary neuron-specific K-Cl cotransporter (KCC2) discovery engine. The company aims to improve lives by treating conditions such as epilepsy and pain.

FabricNano Limited, founded in 2018 and headquartered in London, United Kingdom, specializes in cell-free biomanufacturing, focusing on the development of innovative biocatalysts and artificial cells. The company leverages advancements in nanotechnology and biotechnology to create designs and construction schematics for artificial cells that enhance the speed, purity, and adaptability of chemical reactions. By optimizing these processes, FabricNano enables businesses to streamline production workflows, eliminate capacity bottlenecks, and reduce associated costs, thereby unlocking new possibilities in the realm of biochemistry.

Giving superpowers to medical professionals by transforming messy medical data into useful insights.

Tornado operates a social investment discussion platform aimed at enhancing the skills and profitability of investors. The platform facilitates discussions among users and experts, allowing participants to share and learn investment ideas. By providing tools for portfolio allocation, Tornado enables users to make informed investment decisions tailored to their specific objectives. This approach transforms the investing experience into a more engaging and sophisticated process compared to traditional online brokerages. Tornado's focus on community-driven investment strategies aims to empower investors of all skill levels to improve their profitability and portfolio intelligence.

Kenota Health is a company that specializes in the development of advanced diagnostic tools for allergy testing in humans. Their innovative point-of-care system streamlines the allergy testing process by utilizing a small blood sample, which is analyzed through their equipment to detect allergen sensitization within minutes. This non-invasive technology not only simplifies the testing procedure but also provides timely results directly to healthcare providers, enhancing the overall quality of diagnostic information available to physicians. By offering a safer and more cost-effective alternative to traditional allergy testing methods, Kenota Health aims to improve patient outcomes and facilitate better healthcare decision-making.

Founded in 2018, Slingshot is a San Francisco-based company developing decentralized finance (DeFi) trading platforms. It facilitates secure, trustless, and self-sovereign digital asset transactions for retail users, aggregating prices across multiple exchanges.

PowerTrade is a mobile-based platform that specializes in crypto options and derivatives trading, allowing users to engage in options, futures, perpetuals, and hedging from a single interface. The platform is designed to deliver a user-friendly experience, focusing on simplicity and speed to cater to the needs of traders. By offering competitive pricing and lower margin requirements, PowerTrade aims to enhance return on investment for its users. Additionally, it provides a request for quote (RFQ) feature, which helps traders manage risks and secure favorable prices for larger and more complex trades. Overall, PowerTrade seeks to empower professional traders by optimizing profit opportunities while minimizing the risks associated with trading in the cryptocurrency market.

Injective Labs is a software development company specializing in decentralized finance solutions. It is a core contributor to Injective, an open-source blockchain designed specifically for financial applications.

DrugBank is a leading provider of pharmaceutical knowledge databases. It offers an extensive suite of products powered by the world's most comprehensive and up-to-date drug information. The company enables businesses to enhance healthcare delivery through precision medicine and clinical software applications, while also facilitating drug discovery through data science. DrugBank's structured datasets are used for uncovering novel drug candidates, identifying repurposing opportunities, and building predictive machine learning models. Additionally, DrugBank Online, a publicly available resource, offers limited datasets for academic and non-commercial researchers.

Sollum Technologies Inc., established in 2015 and headquartered in Montreal, Canada, specializes in designing and manufacturing innovative lighting systems. The company's core product is a smart LED lighting solution that dynamically replicates the full spectrum of natural sunlight, optimizing growth conditions for crops and animals. Sollum works closely with greenhouse producers, tailoring light recipes to match the growth cycles of various plants, regardless of their native climate or greenhouse location. This adaptive technology not only enhances energy efficiency and productivity but also improves produce quality, all while minimizing environmental impact.

Floating Point Group operates a cryptocurrency trading platform designed to provide secure and efficient access to decentralized markets. The platform offers custodial services, market-efficient execution algorithms, and insurance for cryptocurrencies.

TATUM Bioscience is a synthetic biology company developing innovative live biotherapeutics. It employs probiotics engineered with advanced modules to combat antibiotic-resistant diseases and multimodal nanofilaments to stimulate comprehensive antitumor immune responses.

Botpress is an open-source chatbot platform that designs and develops tools for building, deploying, and managing conversational experiences. The platform supports scripted, AI-driven, and application-based chatbots and offers on-premises deployment. It provides a conversational flow management system, natural language understanding, and extensibility that can be managed by non-developers after deployment. Hundreds of thousands of developers and organizations use Botpress to power their conversational strategy.

Tornado operates a social investment discussion platform aimed at enhancing the skills and profitability of investors. The platform facilitates discussions among users and experts, allowing participants to share and learn investment ideas. By providing tools for portfolio allocation, Tornado enables users to make informed investment decisions tailored to their specific objectives. This approach transforms the investing experience into a more engaging and sophisticated process compared to traditional online brokerages. Tornado's focus on community-driven investment strategies aims to empower investors of all skill levels to improve their profitability and portfolio intelligence.

ORA is a Montreal-based startup working with advanced nano-materials to produce unparalleled audio experiences. Their team of sound engineers, chemists and material scientists work with the exciting properties of *Graphene* (the strongest and lightest material known to man) to deliver smaller/lighter, more energy efficient speakers, all while remarkably improving sound quality. With a simple drop-in replacement of the speaker’s membrane, GrapheneQ can 1) extend the battery life of a portable audio device by up to 70% b) generate up to 4x the volume and c) significantly reduce the overall size of the speaker, allowing for bigger batteries/thinner devices. ORA's technology is disrupting a technology that has seen little innovation since its invention in 1921: the loudspeaker!

InVivo AI is a Montreal-based company founded in 2017 that specializes in leveraging artificial intelligence to enhance pharmaceutical research and development, with a particular focus on preclinical toxicology. The company has developed advanced AI methods for molecular representation, structure and ligand-based de novo design, and multiparameter optimization, enabling the creation of novel chemistry to address complex biological challenges.

Ourly is a digital allowance platform for banks that provides tools to remove the friction that parents and kids struggle with regarding money matters. Their best-in-breed SaaS platform empowers financial institutions to “turn on” financial literacy as a youth banking solution – standalone or integrated.

Nomic is a bioengineering company developing the nELISA platform for measuring proteins at scale and high throughput. They offer protein profiling solutions empowering scientists to decide experiment scope and scale.

StreamingFast develops highly scalable open-source software for processing and indexing blockchain data. Established by experienced tech entrepreneurs, the company specializes in large-scale data science.

Nimble Science Ltd. is a digital health company focused on revolutionizing gastrointestinal (GI) health through its innovative SIMBA capsule technology. This end-to-end platform facilitates multi-omic mapping of the GI tract, allowing for the passive sampling of small bowel luminal fluid. By leveraging this advanced sampling method, Nimble Science provides precision datasets that offer valuable insights into GI health, thereby transforming the diagnosis and treatment of gastrointestinal conditions. The company's approach enables healthcare providers to directly sample and analyze targeted regions of the GI tract, marking a significant advancement in the understanding and management of GI health.

HumanFirst is the playground for prompt and data work. Experiment with raw data, surface business-specific insights, and build reliable AI workflows with speed, accuracy, and trust. With a low-code platform and enterprise-grade security posture, HumanFirst empowers enterprises to transform every team into AI experts.

Sollum Technologies Inc., established in 2015 and headquartered in Montreal, Canada, specializes in designing and manufacturing innovative lighting systems. The company's core product is a smart LED lighting solution that dynamically replicates the full spectrum of natural sunlight, optimizing growth conditions for crops and animals. Sollum works closely with greenhouse producers, tailoring light recipes to match the growth cycles of various plants, regardless of their native climate or greenhouse location. This adaptive technology not only enhances energy efficiency and productivity but also improves produce quality, all while minimizing environmental impact.

Seqera develops workflow orchestration software for life sciences research. Its open-source platform simplifies complex data analysis pipelines, enabling scientists to conduct research faster on larger datasets across multi-cloud environments.