LivaNova

Cadence Neuroscience, Inc. is an early-stage company focused on developing innovative medical device therapies for epilepsy, central pain, and other neurological disorders. Founded in 2017 and based in Redmond, Washington, the company is leveraging core technology developed at the Mayo Clinic, which is currently under clinical evaluation. Cadence's implantable devices are designed to detect specific brain signals and deliver tailored electrical stimulation to modify neural circuit activity. This approach aims to enhance seizure control and improve treatment methods, offering medical practitioners a customizable solution for managing neurological conditions.

ALung Technologies is a medical device manufacturing company based in Pittsburgh, Pennsylvania, founded in 1997. The company specializes in developing devices for gas exchange to treat acute and chronic respiratory disorders. Its primary product, the Hemolung Respiratory Assist System (RAS), functions as a dialysis-like alternative or supplement to mechanical ventilation, allowing physicians to effectively remove carbon dioxide from the blood without relying solely on the lungs. This technology aims to reduce the need for intubation and invasive ventilation, thereby improving patient outcomes. Additionally, ALung offers the Hattler Catheter, which facilitates the insertion of its gas exchange devices into the central venous bloodstream.

Noctrix Health, Inc. is an early-stage medical device company based in Menlo Park, California, founded in 2018. The company specializes in developing therapeutic wearable devices aimed at treating chronic neurological and sleep disorders, particularly focusing on restless leg syndrome. Its innovative device utilizes neural circuitry to alleviate symptoms and promote undisturbed sleep, empowering patients to better manage their chronic medical conditions.

ShiraTronics, Inc. is a company that specializes in developing and commercializing neuromodulation therapies aimed at treating chronic migraines, a condition that significantly impacts the lives of millions worldwide. Founded in 2018 and headquartered in Ireland, with an additional location in Minneapolis, Minnesota, ShiraTronics is focused on addressing unmet clinical needs in neurology. The company's innovative technologies offer new approaches to effectively alleviate the debilitating effects of migraine headaches, thereby striving to improve the quality of life for those affected by this disabling disorder.

Ceribell, Inc. is a medical technology company that designs and manufactures devices for electroencephalography (EEG) data acquisition and interpretation, aimed at improving the diagnosis and management of neurological conditions. Its flagship product, the Ceribell EEG System, includes a flexible EEG Headband that accommodates various hair types and head sizes, alongside a portable EEG Recorder that ensures clinical-quality data and on-device display. The system is designed to be set up by any healthcare provider within six minutes, making EEG testing more accessible and efficient. Notably, it features a unique function that converts brainwaves into sound, allowing for quicker detection of seizures without the need for specialized technicians. This innovation facilitates earlier diagnosis and targeted treatment for patients, particularly for non-convulsive seizures, thereby reducing the risk of complications and improving overall patient outcomes. Established in 2014 and based in Mountain View, California, Ceribell is committed to enhancing care in hospital ICUs, inpatient units, and emergency departments.

TandemLife develops, manufactures, and markets innovative medical device products to provide Cardiologists and Cardiac Surgeons from around the world with unique solutions for patients requiring circulatory support. The FDA-cleared TandemHeart® System delivers extracorporeal circulatory support in just minutes... not hours. Used by cardiologists in the cath lab and by cardiac surgeons in the OR (operating room), TandemHeart® can provide up to 5.0 lpm of circulatory support when used percutaneously, and up to 8.0 lpm of circulatory support with a direct surgical cannulation method. TandemHeart® is comprised of three major sub-systems: (1) the TandemHeart® Pump provides circulating power to pull oxygenated blood from the left atrium and to return it to the systemic arterial circulation; (2) the TandemHeart® Cannulae Set connects the pump to the body by way of two percutaneous access points in the patient’s groin; and (3) the TandemHeart® Controllers provide operating power to the pump, provides a controlled flow of lubricant to the pump, and also provides automatic system-monitoring and alarms that indicate conditions which require immediate attention

ImThera Medical is a San Diego, California based medical device company. The company’s mission is to help Obstructive Sleep Apnea (OSA) patients live longer and enjoy better lives while substantially reducing the health care costs related to the serious complications associated with OSA. ImThera's sleep apnea implant is based on neurostimulation technology, delivering muscle tone to key tongue muscles during sleep, hence opening the upper airway and substantially reducing or eliminating OSA events. An estimated 28 million Americans suffer from OSA and while CPAP is the established therapy, studies show that less than 50% of patients comply with CPAP therapy. ImThera's THN Sleep Therapy System is a proprietary therapeutic solution that promises an exciting, new era in sleep apnea treatment. www.ImTheraMedical.com.

HighLife is a medical technology company specializing in Transcatheter Mitral Valve Replacement (TMVR) aimed at treating patients with mitral valve regurgitation. Co-founded in 2010 by Georg Börtlein, the company is developing a minimally invasive prosthetic mitral valve that can be implanted in a beating heart while preserving the native valve structure and surrounding anatomy. The innovative system allows for delivery through a transseptal passage via the femoral vein, enabling a reversible procedure that minimizes patient trauma during complex heart surgeries. HighLife's focus is on ensuring ease and safety of use, contributing to improved treatment outcomes for patients. The company's technology is currently undergoing clinical evaluation.

Caisson Interventional, LLC, founded in 2012 and based in Maple Grove, Minnesota, is a clinical-stage medical device company specializing in the design and development of a novel percutaneous mitral valve replacement system. This innovative system is engineered to be delivered across the heart's septum through the femoral vein, allowing for repositioning or withdrawal before final deployment. As a subsidiary of LivaNova PLC since May 2017, Caisson Interventional focuses on advancing its technology through clinical evaluation to improve patient outcomes in heart valve replacement procedures.

MD Start is an incubator and fund dedicated to medical technologies. MD Start creates, develops, and operates medical projects, turning them into new companies with both strategic and hands-on approaches, in order to bring them to investment stage and commercial development.