LivaNova

LivaNova PLC is a global medical technology company with a strong focus on improving the lives of patients with chronic diseases. Established from the merger of Cyberonics and Sorin, LivaNova specializes in cardiopulmonary solutions, including heart-lung machines and oxygenation equipment, as well as neuromodulation devices for treating epilepsy and depression. The company has divested its cardiac rhythm management and heart valve businesses to concentrate on its core offerings. With a presence in over 100 countries and a workforce of approximately 4,000 employees, LivaNova derives around half of its revenue from the United States, 21% from Europe, and the remainder from other global markets. The company is committed to adhering to high standards of business ethics and compliance while delivering innovative solutions that provide both clinical and economic value to healthcare professionals and systems.

Vladimir Makatsaria

CEO and Board Member

11 past transactions

Cadence Neuroscience

Venture Round in 2023
Cadence Neuroscience, Inc. is an early-stage company focused on developing innovative medical device therapies for epilepsy, central pain, and other neurological disorders. Founded in 2017 and based in Redmond, Washington, the company is leveraging core technology developed at the Mayo Clinic, which is currently under clinical evaluation. Cadence's implantable devices are designed to detect specific brain signals and deliver tailored electrical stimulation to modify neural circuit activity. This approach aims to enhance seizure control and improve treatment methods, offering medical practitioners a customizable solution for managing neurological conditions.

ALung

Acquisition in 2022
ALung Technologies, Inc., established in 1997 and based in Pittsburgh, Pennsylvania, specializes in developing and manufacturing medical devices for treating acute respiratory failure. The company's primary product is the Hemolung Respiratory Assist System, a dialysis-like device that removes carbon dioxide and delivers oxygen directly to the blood, allowing patients' lungs to rest and heal while avoiding intubation and facilitating protective ventilation.

Noctrix Health

Series B in 2021
Noctrix Health, Inc. is an early-stage medical device company based in Menlo Park, California, founded in 2018. The company specializes in developing therapeutic wearable devices aimed at treating chronic neurological and sleep disorders, particularly focusing on restless leg syndrome. Its innovative device utilizes neural circuitry to alleviate symptoms and promote undisturbed sleep, empowering patients to better manage their chronic medical conditions.

ShiraTronics

Series A in 2019
ShiraTronics, Inc. is a company that specializes in developing and commercializing neuromodulation therapies aimed at treating chronic migraines, a condition that significantly impacts the lives of millions worldwide. Founded in 2018 and headquartered in Ireland, with an additional location in Minneapolis, Minnesota, ShiraTronics is focused on addressing unmet clinical needs in neurology. The company's innovative technologies offer new approaches to effectively alleviate the debilitating effects of migraine headaches, thereby striving to improve the quality of life for those affected by this disabling disorder.

Ceribell

Series B in 2018
Ceribell, Inc. is a medical technology company that designs and manufactures devices for electroencephalography (EEG) data acquisition and interpretation, aimed at improving the diagnosis and management of neurological conditions. Its flagship product, the Ceribell EEG System, includes a flexible EEG Headband that accommodates various hair types and head sizes, alongside a portable EEG Recorder that ensures clinical-quality data and on-device display. The system is designed to be set up by any healthcare provider within six minutes, making EEG testing more accessible and efficient. Notably, it features a unique function that converts brainwaves into sound, allowing for quicker detection of seizures without the need for specialized technicians. This innovation facilitates earlier diagnosis and targeted treatment for patients, particularly for non-convulsive seizures, thereby reducing the risk of complications and improving overall patient outcomes. Established in 2014 and based in Mountain View, California, Ceribell is committed to enhancing care in hospital ICUs, inpatient units, and emergency departments.

TandemLife

Acquisition in 2018
TandemLife specializes in the development and manufacturing of innovative medical devices designed to assist cardiologists and cardiac surgeons in providing circulatory support for patients experiencing heart failure. The company’s flagship product, the TandemHeart System, is FDA-cleared and allows for rapid extracorporeal circulatory support, operational in minutes rather than hours. This system can deliver varying levels of circulatory support, up to 5.0 liters per minute through percutaneous methods, and up to 8.0 liters per minute using direct surgical cannulation. The TandemHeart System consists of three key components: the TandemHeart Pump, which circulates oxygenated blood; the Cannulae Set, which connects the pump to the patient; and the Controllers, which manage the pump's operation and monitor system performance. By enabling efficient and effective cardiopulmonary bypass procedures, TandemLife aims to enhance patient outcomes while potentially lowering healthcare costs.

ImThera Medical

Acquisition in 2017
ImThera Medical, Inc. is a San Diego-based medical device company focused on developing implantable neurostimulation devices for the treatment of obstructive sleep apnea (OSA). Founded in 2004, the company offers the THN Sleep Therapy System, which includes the aura6000 device. This innovative system delivers mild stimulation to key tongue muscles during sleep, helping to maintain airway openness and significantly reducing or eliminating OSA events. With an estimated 28 million Americans affected by OSA, compliance with traditional CPAP therapy remains a challenge for many patients. ImThera's solution aims to improve patient outcomes and quality of life while potentially lowering healthcare costs associated with OSA complications. As of January 2018, ImThera Medical operates as a subsidiary of LivaNova PLC.

HighLife

Series A in 2017
HighLife is a medical technology company specializing in Transcatheter Mitral Valve Replacement (TMVR) aimed at treating patients with mitral valve regurgitation. Co-founded in 2010 by Georg Börtlein, the company is developing a minimally invasive prosthetic mitral valve that can be implanted in a beating heart while preserving the native valve structure and surrounding anatomy. The innovative system allows for delivery through a transseptal passage via the femoral vein, enabling a reversible procedure that minimizes patient trauma during complex heart surgeries. HighLife's focus is on ensuring ease and safety of use, contributing to improved treatment outcomes for patients. The company's technology is currently undergoing clinical evaluation.

Caisson Interventional

Acquisition in 2017
Caisson Interventional, LLC, founded in 2012 and based in Maple Grove, Minnesota, is a clinical-stage medical device company specializing in the design and development of a novel percutaneous mitral valve replacement system. This innovative system is engineered to be delivered across the heart's septum through the femoral vein, allowing for repositioning or withdrawal before final deployment. As a subsidiary of LivaNova PLC since May 2017, Caisson Interventional focuses on advancing its technology through clinical evaluation to improve patient outcomes in heart valve replacement procedures.

MD Start

Venture Round in 2016
MD Start SA is a medical technology incubator based in Lausanne, Switzerland, that specializes in transforming innovative ideas into viable medical solutions. Founded in 2009, the company creates, develops, and operates medical projects, effectively turning them into new companies. MD Start employs both strategic and hands-on approaches to guide these projects through the investment stage and into commercial development. The firm collaborates with notable partners in the medical device sector, including Medtronic, Sofinnova Partners, and Versant Ventures, among others. Through its focused efforts, MD Start aims to support the growth of medical device start-ups and facilitate the advancement of healthcare technologies.

Cyberonics

Acquisition in 2015
Cyberonics is a company dedicated to developing and marketing medical device solutions for individuals suffering from epilepsy, depression, and other chronic disorders. Their focus is on improving the lives of patients and their families through innovative and patient-focused technology. With a commitment to advancing device-based solutions, Cyberonics aims to provide effective and accessible treatment options for those in need.
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