Care Capital

Care Capital is a venture capital investment firm based in Princeton, New Jersey, founded in 2021. The company focuses on the life sciences and pharmaceutical sectors, seeking to invest in entrepreneurial firms that are developing innovative pharmaceutical assets. Care Capital not only provides investment opportunities but also assists management teams in navigating scientific, strategic, and operational challenges to enhance their potential for success.

Jan Leschly

Chairman

Misha Lozovik

Associate

33 past transactions

CoLucid Pharmaceuticals

Series C in 2015
CoLucid Pharmaceuticals, Inc. is a biotechnology company dedicated to developing therapies for central nervous system disorders. The company focuses on innovative treatments for migraine headaches and other neurological conditions. It is advancing COL-144, a neurally acting anti-migraine agent aimed at effectively treating migraines. Additionally, CoLucid is working on COL-204, a conjugated stigmine platform that generates new chemical entities for addressing a range of conditions, including sleep/wake disorders, chronic pain, Alzheimer's disease, and psychiatric disorders. Established in 2005, CoLucid Pharmaceuticals is headquartered in Research Triangle Park, North Carolina.

Inotek Pharmaceuticals

Venture Round in 2013
Inotek Pharmaceuticals is developing molecules with novel mechanisms of action to fulfill major unmet medical needs in significant diseases of the eye. Complete loss of vision or vision impairment currently affects 3.3 million people over the age of 40 in the United States, with the most common diseases including age-related macular degeneration (AMD), glaucoma, cataract and diabetic retinopathy. With the continued aging of the population, the National Eye Institute projects that this number will grow to 5.5 million people by the year 2020.

Inotek Pharmaceuticals

Debt Financing in 2013
Inotek Pharmaceuticals is developing molecules with novel mechanisms of action to fulfill major unmet medical needs in significant diseases of the eye. Complete loss of vision or vision impairment currently affects 3.3 million people over the age of 40 in the United States, with the most common diseases including age-related macular degeneration (AMD), glaucoma, cataract and diabetic retinopathy. With the continued aging of the population, the National Eye Institute projects that this number will grow to 5.5 million people by the year 2020.

Agile Therapeutics

Series C in 2012
Agile Therapeutics, Inc. is a women's healthcare company based in Princeton, New Jersey, dedicated to the research, development, and commercialization of prescription contraceptive products. The company's lead product is Twirla, a once-weekly transdermal contraceptive patch that combines levonorgestrel and ethinyl estradiol, designed to provide a non-daily option for contraception. Agile Therapeutics is also advancing a pipeline of additional products and extensions related to Twirla, including regimens aimed at offering women extended cycles, shorter and lighter periods, and a progestin-only patch for those who cannot or prefer not to use estrogen. Utilizing proprietary Skinfusion technology, the company aims to deliver effective contraceptive solutions that address the unmet health needs of women today. Founded in 1997, Agile Therapeutics continues to focus on innovating women's healthcare options.

Elevation Pharmaceuticals

Series B in 2012
Founded in 2008, Elevation Pharmaceuticals is developing a pipeline of improved aerosol drug products for COPD patients. There founding team has a successful track record starting companies and building dedicated teams to develop new drug products that improve patients' lives. At Elevation, they have a disciplined approach to strategic decision-making that helps us stay focused on the path with the highest probability of success. They are executing our drug development plans with passion, integrity, and a high sense of urgency in order to meet the needs and expectations of our stakeholders -- employees, investors, partners, and patients.

Elevation Pharmaceuticals

Series A in 2011
Founded in 2008, Elevation Pharmaceuticals is developing a pipeline of improved aerosol drug products for COPD patients. There founding team has a successful track record starting companies and building dedicated teams to develop new drug products that improve patients' lives. At Elevation, they have a disciplined approach to strategic decision-making that helps us stay focused on the path with the highest probability of success. They are executing our drug development plans with passion, integrity, and a high sense of urgency in order to meet the needs and expectations of our stakeholders -- employees, investors, partners, and patients.

CoLucid Pharmaceuticals

Venture Round in 2011
CoLucid Pharmaceuticals, Inc. is a biotechnology company dedicated to developing therapies for central nervous system disorders. The company focuses on innovative treatments for migraine headaches and other neurological conditions. It is advancing COL-144, a neurally acting anti-migraine agent aimed at effectively treating migraines. Additionally, CoLucid is working on COL-204, a conjugated stigmine platform that generates new chemical entities for addressing a range of conditions, including sleep/wake disorders, chronic pain, Alzheimer's disease, and psychiatric disorders. Established in 2005, CoLucid Pharmaceuticals is headquartered in Research Triangle Park, North Carolina.

Inotek Pharmaceuticals

Series D in 2011
Inotek Pharmaceuticals is developing molecules with novel mechanisms of action to fulfill major unmet medical needs in significant diseases of the eye. Complete loss of vision or vision impairment currently affects 3.3 million people over the age of 40 in the United States, with the most common diseases including age-related macular degeneration (AMD), glaucoma, cataract and diabetic retinopathy. With the continued aging of the population, the National Eye Institute projects that this number will grow to 5.5 million people by the year 2020.

BioCritica

Private Equity Round in 2011
BioCritica is a biotechnology company dedicated to addressing the critical care needs of patients and clinicians within the hospital environment. The company is known for its product Xigris, which is designed for the treatment of severe sepsis. In addition to Xigris, BioCritica is actively developing a pipeline of other medical products aimed at significantly improving patient outcomes and quality of life. Through its focused efforts, the company seeks to enhance healthcare delivery in critical care settings.

Agile Therapeutics

Series B in 2010
Agile Therapeutics, Inc. is a women's healthcare company based in Princeton, New Jersey, dedicated to the research, development, and commercialization of prescription contraceptive products. The company's lead product is Twirla, a once-weekly transdermal contraceptive patch that combines levonorgestrel and ethinyl estradiol, designed to provide a non-daily option for contraception. Agile Therapeutics is also advancing a pipeline of additional products and extensions related to Twirla, including regimens aimed at offering women extended cycles, shorter and lighter periods, and a progestin-only patch for those who cannot or prefer not to use estrogen. Utilizing proprietary Skinfusion technology, the company aims to deliver effective contraceptive solutions that address the unmet health needs of women today. Founded in 1997, Agile Therapeutics continues to focus on innovating women's healthcare options.

NormOxys

Series B in 2010
NormOxys, Inc. is a biotechnology company based in Boston, Massachusetts, specializing in the development of small molecule drugs for oncology treatment. Founded in 2003 and originally named Oxyplus, Inc., the company changed its name to NormOxys, Inc. in October 2008. It is known for its proprietary product, OXY111A, an effective anti-cancer drug that acts as a novel allosteric modulator, regulating the binding affinity between oxygen and hemoglobin. This mechanism enhances the body’s ability to deliver oxygen to diseased tissues, thereby providing patients with non-toxic therapeutic options.

Vaxart

Series B in 2010
Vaxart, Inc. is a clinical-stage biotechnology company based in South San Francisco, California, specializing in the discovery and development of oral recombinant protein vaccines using its proprietary vaccine platform. The company is focused on creating oral vaccines that can generate broad and durable immune responses against various infectious diseases. Its product pipeline includes an oral tablet vaccine for norovirus, which has completed Phase I clinical trials, a seasonal influenza vaccine currently in Phase II trials, and vaccines targeting respiratory syncytial virus and coronavirus. Additionally, Vaxart is developing therapeutic vaccines for human papillomavirus-related conditions. The company aims to improve vaccination rates by offering a convenient, room temperature-stable tablet format, which is easier to distribute and administer compared to traditional injectable vaccines. Vaxart also has a research collaboration with Janssen Vaccines & Prevention B.V. to explore its oral vaccine platform for a universal influenza vaccine program.

Elevation Pharmaceuticals

Series A in 2010
Founded in 2008, Elevation Pharmaceuticals is developing a pipeline of improved aerosol drug products for COPD patients. There founding team has a successful track record starting companies and building dedicated teams to develop new drug products that improve patients' lives. At Elevation, they have a disciplined approach to strategic decision-making that helps us stay focused on the path with the highest probability of success. They are executing our drug development plans with passion, integrity, and a high sense of urgency in order to meet the needs and expectations of our stakeholders -- employees, investors, partners, and patients.

MicroCHIPS

Venture Round in 2010
MicroCHIPS Biotech, Inc. specializes in developing a microchip-based implant designed for drug delivery applications across various therapeutic areas, including osteoporosis, diabetes, multiple sclerosis, women’s contraception, and pain management. This innovative implant can store and release precise doses of medication over extended periods, offering an alternative to traditional therapies that rely on frequent injections. The implant is surgically placed under the skin during a minimally invasive procedure and can be wirelessly activated or deactivated by healthcare providers or patients. Additionally, the device allows for real-time adjustments to the drug dosage and frequency, catering to the specific needs of each patient. Established in 1999 and headquartered in Lexington, Massachusetts, MicroCHIPS operates as a subsidiary of Daré Bioscience, Inc.

Anacor Pharmaceuticals

Series E in 2009
Anacor Pharmaceuticals, Inc. is a biopharmaceutical company specializing in the discovery, development, and commercialization of small-molecule therapeutics based on its unique boron chemistry platform. The company is known for its marketed product, KERYDIN, a topical solution for treating onychomycosis, a fungal infection of the toenails. Anacor's lead product candidate, crisaborole topical ointment, is an anti-inflammatory therapy currently undergoing Phase III clinical trials for mild-to-moderate atopic dermatitis and psoriasis. Additionally, the company is developing AN3365, an antibiotic aimed at treating infections caused by Gram-negative bacteria. Anacor has established collaboration agreements with various organizations to advance drug candidates targeting diseases such as African trypanosomiasis, tuberculosis, and other neglected tropical diseases. Founded in 2000 and headquartered in Palo Alto, California, Anacor Pharmaceuticals was previously known as AnaMax, Inc. and became a subsidiary of Pfizer Inc. in 2016.

CoLucid Pharmaceuticals

Series B in 2008
CoLucid Pharmaceuticals, Inc. is a biotechnology company dedicated to developing therapies for central nervous system disorders. The company focuses on innovative treatments for migraine headaches and other neurological conditions. It is advancing COL-144, a neurally acting anti-migraine agent aimed at effectively treating migraines. Additionally, CoLucid is working on COL-204, a conjugated stigmine platform that generates new chemical entities for addressing a range of conditions, including sleep/wake disorders, chronic pain, Alzheimer's disease, and psychiatric disorders. Established in 2005, CoLucid Pharmaceuticals is headquartered in Research Triangle Park, North Carolina.

Inotek Pharmaceuticals

Series C in 2007
Inotek Pharmaceuticals is developing molecules with novel mechanisms of action to fulfill major unmet medical needs in significant diseases of the eye. Complete loss of vision or vision impairment currently affects 3.3 million people over the age of 40 in the United States, with the most common diseases including age-related macular degeneration (AMD), glaucoma, cataract and diabetic retinopathy. With the continued aging of the population, the National Eye Institute projects that this number will grow to 5.5 million people by the year 2020.

NephroGenex

Series A in 2007
NephroGenex is a drug-development company focusing on kidney disease. The Company is developing Pyridorinâ„¢ (pyridoxamine dihydrochloride) as a treatment to slow the progression of diabetic kidney disease.

Orqis Medical

Series D in 2007
ORQIS Medical Corporation operates as a medical device company. It develops and sells minimally invasive devices for improving cardiac performance through aortic flow therapy. It offers Cancion System, a heart failure treatment that uses continuous aortic flow augmentation technology to improve symptoms of heart failure and change the underlying course of the disease for patients hospitalized for de-compensated heart failure. The company’s products also include Exeleras System to treat chronic heart failure patients.

CardioKine

Series B in 2006
CardioKine, Inc. is a specialty pharmaceutical company based in Philadelphia, Pennsylvania, founded in 2004. The company focuses on developing innovative pharmaceuticals aimed at the prevention and treatment of cardiovascular diseases. One of its notable products is lixivaptan, an orally active vasopressin receptor antagonist designed for patients with congestive heart failure who experience hyponatremia. CardioKine is dedicated to addressing unmet medical needs in cardiovascular health through its targeted therapeutic compounds.

MPV

Venture Round in 2006
MPV is committed to improving business processes throughout the healthcare revenue cycle, resulting in increased efficiency and lower costs for medical groups, payers, employers and, ultimately, for patients. From improving payer contract management processes to verifying insurance and benefits to generating an accurate estimate of a patient's out-of-pocket expenses, MPV is your partner of choice. Their Web-based revenue cycle solutions enable providers to collect the right payment from the right party in the shortest amount of time, resulting in improved financial performance and a stronger bottom line.

Inotek Pharmaceuticals

Series B in 2005
Inotek Pharmaceuticals is developing molecules with novel mechanisms of action to fulfill major unmet medical needs in significant diseases of the eye. Complete loss of vision or vision impairment currently affects 3.3 million people over the age of 40 in the United States, with the most common diseases including age-related macular degeneration (AMD), glaucoma, cataract and diabetic retinopathy. With the continued aging of the population, the National Eye Institute projects that this number will grow to 5.5 million people by the year 2020.

Anacor Pharmaceuticals

Series C in 2005
Anacor Pharmaceuticals, Inc. is a biopharmaceutical company specializing in the discovery, development, and commercialization of small-molecule therapeutics based on its unique boron chemistry platform. The company is known for its marketed product, KERYDIN, a topical solution for treating onychomycosis, a fungal infection of the toenails. Anacor's lead product candidate, crisaborole topical ointment, is an anti-inflammatory therapy currently undergoing Phase III clinical trials for mild-to-moderate atopic dermatitis and psoriasis. Additionally, the company is developing AN3365, an antibiotic aimed at treating infections caused by Gram-negative bacteria. Anacor has established collaboration agreements with various organizations to advance drug candidates targeting diseases such as African trypanosomiasis, tuberculosis, and other neglected tropical diseases. Founded in 2000 and headquartered in Palo Alto, California, Anacor Pharmaceuticals was previously known as AnaMax, Inc. and became a subsidiary of Pfizer Inc. in 2016.

Inotek Pharmaceuticals

Series A in 2004
Inotek Pharmaceuticals is developing molecules with novel mechanisms of action to fulfill major unmet medical needs in significant diseases of the eye. Complete loss of vision or vision impairment currently affects 3.3 million people over the age of 40 in the United States, with the most common diseases including age-related macular degeneration (AMD), glaucoma, cataract and diabetic retinopathy. With the continued aging of the population, the National Eye Institute projects that this number will grow to 5.5 million people by the year 2020.

CardioKine

Series A in 2004
CardioKine, Inc. is a specialty pharmaceutical company based in Philadelphia, Pennsylvania, founded in 2004. The company focuses on developing innovative pharmaceuticals aimed at the prevention and treatment of cardiovascular diseases. One of its notable products is lixivaptan, an orally active vasopressin receptor antagonist designed for patients with congestive heart failure who experience hyponatremia. CardioKine is dedicated to addressing unmet medical needs in cardiovascular health through its targeted therapeutic compounds.

Archemix

Series B in 2004
Archemix Corp. is a biotechnology company based in Cambridge, Massachusetts, focused on the discovery, development, and commercialization of therapeutic aptamers for the prevention and treatment of both chronic and acute diseases. Established in 2000, Archemix is known for its aptamer product candidates, including ARC1779, which is aimed at treating thrombotic microangiopathies and is also relevant for use in carotid endarterectomy procedures. In addition to its work in these areas, the company is developing aptamer therapeutics targeting various conditions in the fields of cardiovascular health, hematology, and oncology.

Tercica

Series B in 2003
Tercica Inc., a biotechnology company, engages in the development and commercialization of therapeutics for the treatment of endocrine and metabolic diseases. Its products include Increlex, an rDNA origin injection for the long-term treatment of children with short stature due to severe primary IGFD; and Somatuline Depot, a lanreotide injection for the treatment of adults with acromegaly. Tercica Inc. has strategic partnerships with Genentech and Ipsen SA. The company was founded in 2002 and is based in Brisbane, California. As of October 16, 2008, Tercica Inc. operates as a subsidiary of Ipsen S.A.

Orqis Medical

Series C in 2003
ORQIS Medical Corporation operates as a medical device company. It develops and sells minimally invasive devices for improving cardiac performance through aortic flow therapy. It offers Cancion System, a heart failure treatment that uses continuous aortic flow augmentation technology to improve symptoms of heart failure and change the underlying course of the disease for patients hospitalized for de-compensated heart failure. The company’s products also include Exeleras System to treat chronic heart failure patients.

Renovo

Series B in 2002
Renovo is a biopharmaceutical product company specializing in the development of drugs to reduce scarring, improve wound healing, and enhance tissue regeneration. With a focus on addressing the unmet market need for scar reduction pharmaceuticals in the US and Europe, Renovo is advancing a pipeline that includes one drug in phase 3 clinical development, two drugs in phase 2 clinical development, and several pre-clinical candidates. As a leader in this space, Renovo is dedicated to bringing innovative solutions to market to improve patient outcomes and quality of life.

Archemix

Series A in 2002
Archemix Corp. is a biotechnology company based in Cambridge, Massachusetts, focused on the discovery, development, and commercialization of therapeutic aptamers for the prevention and treatment of both chronic and acute diseases. Established in 2000, Archemix is known for its aptamer product candidates, including ARC1779, which is aimed at treating thrombotic microangiopathies and is also relevant for use in carotid endarterectomy procedures. In addition to its work in these areas, the company is developing aptamer therapeutics targeting various conditions in the fields of cardiovascular health, hematology, and oncology.

Dynavax Technologies

Series D in 2002
Dynavax Technologies Corporation is a biopharmaceutical company specializing in the development and commercialization of innovative vaccines. Its flagship product, HEPLISAV-B, is a recombinant adjuvanted hepatitis B vaccine approved for use in adults aged 18 years and older, targeting all known subtypes of the hepatitis B virus. The company utilizes its proprietary Toll-like Receptor Immune Modulation Platform to enhance both innate and adaptive immune responses. Dynavax is actively advancing its immuno-oncology portfolio and has several development-stage products, including SD-101 and DV281, aimed at various cancer indications. In addition, the company engages in multiple research collaborations to develop adjuvanted vaccines for infectious diseases, including COVID-19, partnering with organizations such as Clover Biopharmaceuticals, the University of Queensland, and the Coalition for Epidemic Preparedness Innovations. Established in 1996 and headquartered in Emeryville, California, Dynavax continues to expand its role in vaccine development.

Orqis Medical

Series B in 2001
ORQIS Medical Corporation operates as a medical device company. It develops and sells minimally invasive devices for improving cardiac performance through aortic flow therapy. It offers Cancion System, a heart failure treatment that uses continuous aortic flow augmentation technology to improve symptoms of heart failure and change the underlying course of the disease for patients hospitalized for de-compensated heart failure. The company’s products also include Exeleras System to treat chronic heart failure patients.

NitroMed

Series E in 2001
NitroMed is an emerging pharmaceutical company that discovers, develops and seeks to commercialize proprietary pharmaceuticals based on the therapeutic benefits of the naturally-occurring molecule nitric oxide. NitroMed is conducting a late-stage confirmatory trial of our lead nitric oxide-enhancing drug, BiDil, for the treatment of heart failure in African Americans.
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