Fractyl Health Inc. is a medical device company specializing in innovative therapies for metabolic diseases, particularly type 2 diabetes and obesity. The company's flagship product, Revita DMR, is a minimally invasive procedure that utilizes hydrothermal ablation to rejuvenate the lining of the duodenum, effectively addressing the underlying causes of these conditions. By focusing on transforming the treatment of metabolic diseases from merely managing symptoms to providing durable, disease-modifying solutions, Fractyl Health aims to significantly improve patient health outcomes. Founded in 2010 and based in Lexington, Massachusetts, the company is committed to developing curative therapies that lessen the burden on patients, healthcare providers, and payers.
Cartography is shaping a world in which cancer immunotherapies are designed around and directed toward the safest and most effective targets.
Xilis, Inc. develops next generation organoid technologies to guide precision therapy for cancer patients and improve drug discovery. It offers The XilisµO, a platform that enables rapid diagnostics, personalized drug screening, and scalable patient-derived models for high-throughput drug discovery. Xilis, Inc. was founded in 2019 and is based in Chapel Hill, North Carolina.
Developer of drug discovery platform designed for radically accelerating small molecule drug discovery and finding pharmaceutical compounds for medically important targets. The company's technology rapidly analyzes compounds by combining machine learning with DNA-encoded libraries to generate enormous amounts of useful data and parallel biochemical experiments using proprietary artificial intelligence (AI) models, enabling researchers to develop new drugs.
Sickbay, developed by Medical Informatics Corp., is a software platform designed to enhance patient monitoring and analytics in healthcare settings. It archives, aggregates, and transforms high-resolution waveform data from various medical devices, enabling real-time access and analysis of patient information. The platform supports continuous data collection and employs machine learning and artificial intelligence to deliver predictive analytics that facilitate data-driven medicine and patient-centered care. Sickbay also addresses alarm management by reducing alarm noise and ensuring that relevant alerts reach care providers. This comprehensive approach assists doctors, nurses, hospital administrators, and medical researchers in making informed decisions to improve patient outcomes. Founded in 2010 and headquartered in Houston, Texas, Medical Informatics Corp. aims to provide innovative solutions that enhance the efficiency and effectiveness of healthcare delivery.
Biopharmaceutical research and development company that's an affiliate of Clover Health
Octant, Inc. engages in engineering biology to design multi-targeted small molecule drug leads for complex diseases. Its polypharmacology discovery engine generates multi-receptor pathway data and predictive insights to inform rational drug design. The company also engineers biology using living cells as high-throughput signal networks to map, measure, and model chemical structures against G protein-coupled receptors (GPCRs). The company was incorporated in 2017 and is headquartered in Los Angeles, California.
Pheast Therapeutics is a cancer immunotherapy company focused on developing novel checkpoint therapies to harness the innate immune system in the fight against cancer.
Octant, Inc. engages in engineering biology to design multi-targeted small molecule drug leads for complex diseases. Its polypharmacology discovery engine generates multi-receptor pathway data and predictive insights to inform rational drug design. The company also engineers biology using living cells as high-throughput signal networks to map, measure, and model chemical structures against G protein-coupled receptors (GPCRs). The company was incorporated in 2017 and is headquartered in Los Angeles, California.
Celsius Therapeutics, Inc. is a biotechnology company based in Cambridge, Massachusetts, that focuses on the development and research of innovative drugs. Established in 2017, the company utilizes single-cell genomic analysis and machine learning to gain insights into the cellular ecosystems of diseases. This approach allows Celsius Therapeutics to identify critical biomarkers that can enhance patient care and contribute to the creation of transformative medicines. The company's commitment to advancing the understanding of complex diseases positions it as a key player in the biotechnology sector.
RefleXion Medical Inc. specializes in developing a biologically-guided radiotherapy system aimed at transforming cancer treatment. The company’s innovative technology allows tumors to continuously signal their location during therapy, facilitating the simultaneous treatment of multiple tumors, particularly in cases of metastasis. The RefleXion X1 machine is currently cleared for various forms of radiotherapy, including stereotactic body radiotherapy (SBRT) and intensity-modulated radiotherapy (IMRT). At the core of RefleXion's approach is the integration of positron-emission tomography (PET) imaging, which enables real-time tumor tracking and dose adaptation based on the biological characteristics of the tumors. This advancement in radiotherapy promises to enhance precision in cancer treatment, offering a potential paradigm shift in radiation oncology. RefleXion Medical, incorporated in 2009 and based in Hayward, California, has established strategic collaborations, including partnerships with Telix Pharmaceuticals and HealthMyne.
Sherlock Biosciences, Inc., a biotechnology company, develops molecular diagnostics solutions. It offers SHERLOCK, a CRISPR-based method to detect and quantify specific genetic sequences, and INSPECTR, a synthetic biology-based molecular diagnostics platform. The company offers its products in the areas of precision oncology, infection identification, food safety, at-home tests, and disease detection. The company was incorporated in 2018 and is based in Cambridge, Massachusetts.
Satellite Bio specializes in cell therapy, regenerative medicine, synthetic biology, cell biology, and tissue engineering. It focuses on the development and implementation of proprietary, off-the-shelf, implantable satellite organs as living therapeutic solutions that can transform the lives of millions of patients who suffer from serious diseases.
DNA Script is a disruptive DNA synthesis company engineering biology to accelerate breakthroughs in life science and human health. Our revolutionary enzymatic technology powers the world's first benchtop DNA printer, SYNTAX, enabling labs to print their own synthetic oligos for greater workflow control and faster access to results.
Hyperfine Research Inc. specializes in developing portable magnetic resonance imaging (MRI) scanners, aimed at making medical imaging more accessible. Founded in 2014 and based in Guilford, Connecticut, the company focuses on general anatomical brain imaging and addresses various medical conditions, including headaches, strokes, non-specific muscle weakness, encephalopathy, spinal cord compressions, diabetic foot disease, and musculoskeletal trauma. Within a year of its establishment, Hyperfine successfully produced its first images, and it has since improved the quality and functionality of its imaging technology. The company’s mission is to democratize healthcare by ensuring that medical imaging is available to people worldwide.
Iambic Therapeutics focuses on accelerating molecular discovery through its innovative quantum molecular simulation engine. By integrating artificial intelligence and automated synthetic development, the company aims to enhance the design of small-molecule therapeutics. This technology significantly improves the accuracy of molecular predictions, providing valuable insights for therapeutic discovery. Iambic Therapeutics is committed to transforming the drug development process, enabling physicians to access more precise molecular data and ultimately improving treatment outcomes.
Bayesian Health Inc., a digital health company, provides an AI-driven platform that monitors patients illness severity, detecting changes in acuity, and augments provider decision-making to optimize care throughout their hospital stay. Its platform enables clinical staff and hospital leadership to make timely decisions in complex clinical areas. The company was incorporated in 2016 and is based in New York, New York.
Xilis, Inc. develops next generation organoid technologies to guide precision therapy for cancer patients and improve drug discovery. It offers The XilisµO, a platform that enables rapid diagnostics, personalized drug screening, and scalable patient-derived models for high-throughput drug discovery. Xilis, Inc. was founded in 2019 and is based in Chapel Hill, North Carolina.
Enveda Therapeutics is constructing and decoding the largest integrated dataset of anthropological, biological, and chemical information from medicinal plants to inspire new medicines.
Volastra Therapeutics, Inc., a biotechnology company, develops therapies for the treatment of metastatic cancers. The company offers a library of organoids derived from metastatic cancer samples to elucidate how tumors spread and devise therapeutic strategies that target chromosomal instability during the process of cancer metastasis. Volastra Therapeutics, Inc. was incorporated in 2019 and is based in New York, New York.
Immunai Inc. is a biotechnology company focused on developing an artificial intelligence-based immune profiling platform aimed at enhancing drug development, disease detection, diagnosis, and treatment. The company utilizes single-cell genomics and machine learning to conduct high-resolution profiling of the immune system at an industrial scale, generating valuable biological insights that facilitate research and promote novel discoveries. Immunai's platform supports biomarker discovery and helps understand how various cell types respond to their changing environments. Its research and development efforts concentrate on cancer therapies, including blockade and vaccine strategies. The company collaborates with academic institutions, biopharmaceutical firms, and other biotechnology companies to advance its mission of mapping the immune system. Founded in 2018, Immunai is headquartered in New York City, with additional offices in San Francisco, California, and Tel Aviv, Israel.
Cambrian Biopharma is a multi-asset biotech R&D firm uniquely focused on a specific field of biomedical research: the biology of aging, also known as geroscience. We believe the future of medicine should be proactive and committed to extending our best years, not just reactive to certain diseases. As experts in the biology of age-related disease, it is our mission to assemble the world's best scientists to accelerate this paradigm shift. We are built on an emerging business model we call a "Distributed R&D Company" (or "DisCo"), partnering with academic geroscientists to build companies, conduct preclinical drug discovery, and manage clinical trials. Cambrian looks to discover and develop therapeutics that target the molecular damage that arises during aging and leads to chronic disease. Our approach is to build a diverse portfolio led by scientific rigor and data, not ego. Focusing on early-stage therapeutics, we collaborate with pioneering scientists to bring discoveries out of the lab and into the clinic as efficiently as possible. So far, we have launched 10 companies with leading geroscientists and have relationships with more than 100 geroscience-focused labs globally, translating to a toolkit for tech-transfer negotiations and rapid spinouts.
Cambrian Biopharma is a multi-asset biotech R&D firm uniquely focused on a specific field of biomedical research: the biology of aging, also known as geroscience. We believe the future of medicine should be proactive and committed to extending our best years, not just reactive to certain diseases. As experts in the biology of age-related disease, it is our mission to assemble the world's best scientists to accelerate this paradigm shift. We are built on an emerging business model we call a "Distributed R&D Company" (or "DisCo"), partnering with academic geroscientists to build companies, conduct preclinical drug discovery, and manage clinical trials. Cambrian looks to discover and develop therapeutics that target the molecular damage that arises during aging and leads to chronic disease. Our approach is to build a diverse portfolio led by scientific rigor and data, not ego. Focusing on early-stage therapeutics, we collaborate with pioneering scientists to bring discoveries out of the lab and into the clinic as efficiently as possible. So far, we have launched 10 companies with leading geroscientists and have relationships with more than 100 geroscience-focused labs globally, translating to a toolkit for tech-transfer negotiations and rapid spinouts.
Paige builds software to advance the diagnosis, treatment, and biomarker discovery for cancer. The Memorial Sloan Kettering spin-out aims to help pathologists and clinicians make faster, more informed diagnostic and treatment decisions and to bring new digital biomarkers to their practice. Paige’s proprietary Machine Learning solutions provide insights from decades of data from the world’s experts in cancer care and were recently published in Nature Medicine. The company’s first product for prostate cancer detection received Breakthrough Designation from the FDA as a novel therapy that stands to improve diagnostic accuracy while reducing costs to health systems.
Sensei Biotherapeutics, Inc. develops precision cancer therapeutics that target a tumor-specific antigen (aspartate ß-hydroxylase). It offers various cancer immunotherapies, such as cancer vaccines and T-cell therapies for cancer patients. Sensei Biotherapeutics, Inc. was formerly known as Panacea Pharmaceuticals, Inc. The company was founded in 1999 and is based in Gaithersburg, Maryland with an additional office in Boston, Massachusetts.
Faze Medicines, a pharmaceutical company, develops interventions against driver of disease pathology. It develops small molecule drugs for initial therapeutic focus areas, such as amyotrophic lateral sclerosis and myotonic dystrophy type 1. The company was founded in 2020 and is based in Cambridge, Massachusetts.
ATAI Life Sciences AG is a biotech company based in Munich, Germany, with additional offices in Berlin and London. Founded in 2018, ATAI focuses on developing innovative treatments for mental health disorders. The company utilizes a decentralized, technology-driven platform model to efficiently address significant unmet medical needs in this field. By integrating expertise and resources across its portfolio, ATAI aims to accelerate the development of therapies that can create meaningful changes in mental health treatment. Through its commitment to evidence-based solutions, ATAI seeks to improve the lives of millions affected by mental health issues.
Fractyl Health Inc. is a medical device company specializing in innovative therapies for metabolic diseases, particularly type 2 diabetes and obesity. The company's flagship product, Revita DMR, is a minimally invasive procedure that utilizes hydrothermal ablation to rejuvenate the lining of the duodenum, effectively addressing the underlying causes of these conditions. By focusing on transforming the treatment of metabolic diseases from merely managing symptoms to providing durable, disease-modifying solutions, Fractyl Health aims to significantly improve patient health outcomes. Founded in 2010 and based in Lexington, Massachusetts, the company is committed to developing curative therapies that lessen the burden on patients, healthcare providers, and payers.
Glympse Bio, Inc. is focused on developing modular nanoparticle sensors for diagnostics in fibrosis, cancer, immunology, and infectious diseases, as well as for monitoring drug response. The company utilizes engineered diagnostic agents that assess disease states within the body and convey this information to urine for analysis. Its flagship product, Glympse Inside, serves as a pan-disease engine intended to enhance disease monitoring and treatment response. Founded in 2015 and based in Cambridge, Massachusetts, Glympse Bio's innovative platform technology originated at MIT and is backed by a team of experts in nanomedicine and biomedical engineering.