DCVC

Grove Biopharma is a biotechnology company specializing in materials science solutions for peptide therapeutics. It focuses on discovering and developing novel 'protein-like polymers' to address significant unmet medical needs in chronic inflammatory and neurodegenerative diseases.

Mainspring Energy, Inc. is a technology company based in Menlo Park, California, that specializes in developing linear generator technology for low carbon, dispatchable energy solutions. Founded in 2010 by three Stanford engineers, the company focuses on creating advanced prototypes that convert fuel into electricity through a unique, low-temperature reaction of air and fuel. This innovative approach allows Mainspring to offer generators that provide affordable, reliable electricity while significantly reducing carbon emissions compared to traditional electric grids. The company's mission is to address climate change and enhance energy accessibility, contributing to the development of net-zero carbon energy systems for the future.

Solu Therapeutics is a precision medicine company developing therapeutics focused on eliminating disease-driving cells. Its platform combines selective small-molecule binders with proprietary antibodies to create bifunctional therapeutics, targeting inflammatory and autoimmune diseases.

Lumafield provides industrial computed tomography solutions for non-destructive testing and inspection in engineering environments. Its Neptune X-ray CT scanner enables detailed imaging to analyze internal structures and detect defects across materials. The Voyager software platform delivers cloud-based AI-powered analysis, automated inspections, and collaboration tools to support product development from design through manufacturing. Triton is a high-speed CT system designed for rapid scanning in high-volume manufacturing settings. The company serves industries including aerospace, automotive, electronics, and medical devices, helping to improve product quality and reliability through advanced imaging and analysis capabilities.

AgZen is a company that specializes in the development of pesticide sprays designed to adhere to plants, thereby minimizing pollution associated with agricultural chemicals. The firm provides patented, field-tested food-safe additives and sprayer retrofits that enhance the adhesion of agrochemical droplets to crops. This innovative approach allows farmers to achieve effective protection while significantly reducing the volume of pesticides used, without sacrificing plant health or yield. By focusing on sustainability and efficiency, AgZen aims to support agricultural practices that are both environmentally friendly and economically viable for farmers.

Newleos Therapeutics is a stealth-mode biotechnology company focused on developing safer and more effective treatments for neuropsychiatric disorders, aiming to improve mental health outcomes.

Auron Therapeutics is a biotechnology company focused on cancer therapy development that seeks to change the paradigm from tumor cell killing to differentiation therapy, aiming to transform malignant cells into normal functioning cells by reactivating endogenous cellular programs. The company uses platforms that integrate large-omic datasets and miniaturized high-throughput flow cytometry to rapidly identify and validate multiple targets and drugs in primary human patient samples. This approach is designed to advance therapeutic candidates for cancer across areas of unmet medical need and to support the development of transformative medicines. Auron Therapeutics was founded in 2018 and is based in Wellesley, Massachusetts.

Umoja Biopharma is a biotechnology company specializing in innovative immunotherapy aimed at transforming cancer treatment. The company focuses on reprogramming T cells to effectively target cancer within patients' bodies, enhancing the immune response to combat both solid tumors and hematological cancers, which often show poor responses to conventional therapies. Umoja Biopharma's proprietary CAR T-cell gene therapy platform is designed to deliver scalable therapeutic regimens, allowing for tailored treatment options that can be administered to any patient, regardless of tumor type or stage. This approach aims to improve patient outcomes and quality of life by providing a safe and controllable method to attack cancer directly.

Alta Resource Technologies specializes in innovative mining technology, utilizing advanced biochemistry to efficiently extract critical minerals, such as rare earth elements, from diverse feedstocks. Their proprietary platform employs customizable proteins for highly selective separation, reducing environmental impact and enabling clients to meet materials demand for advanced technologies like semiconductors.

Founded in 2017, Fervo Energy specializes in developing and operating geothermal assets using proprietary technology. Based in San Francisco, the company generates clean power through innovative geoscience methods, aiming to provide a dispatchable foundation for a 100% clean energy future.

Slip Robotics specializes in automated trailer loading and unloading technology. Its SlipBot robots enable truck drivers to load/unload trailers in under five minutes with a single button command, reducing wait times and improving safety across supply chains.

Radiant is a clean energy startup based in Los Angeles, California, that specializes in the development of portable nuclear microreactors. Founded in 2019, the company aims to provide an alternative to fossil fuels for both military and commercial applications. Its flagship product, the Kaleidos microreactor, is designed to fit within a shipping container, allowing for transportation by air, ship, and road. This innovative microreactor serves as a zero-emissions power source, making it particularly suitable for remote locations and critical applications where traditional diesel generators are typically used.

Reality Defender specializes in detecting deepfakes and AI-generated media across various formats such as audio, video, images, and text. Its patented multimodal approach enables real-time detection of advanced impersonations, helping mitigate risks associated with manipulated content. The platform offers flexible deployment options that integrate smoothly into existing infrastructure.

Q-CTRL develops software tools and firmware for quantum computing to reduce and control quantum bit errors in quantum hardware. Its quantum control infrastructure software supports research and development professionals and end users, accelerating the pathway to the first useful quantum computers and underpinning software-defined quantum sensors for defence, intelligence, navigation, and earth observation. The company collaborates with universities, national labs, and industry partners to advance hardware error management and stability in quantum systems.

Zap Energy, Inc. is a Seattle-based company that specializes in the design and manufacture of sheared-flow stabilized Z-Pinch fusion reactors for power generation. Founded in 2017, the company focuses on developing compact and scalable fusion technology that offers low-carbon, cost-effective, and flexible energy solutions. Unlike conventional fusion methods, Zap Energy's approach utilizes electric current to create magnetic fields that confine and compress plasma, enhancing the stability and efficiency of the fusion process. This innovative technology aims to provide sustainable energy while requiring less capital investment compared to traditional fusion systems.

Twelve, formerly known as Opus 12, is a Berkeley, California-based company that specializes in recycling carbon dioxide emissions into valuable chemicals and fuels. Founded in 2015, the company has developed innovative technology that can be integrated with any source of CO₂ emissions. By utilizing only water and electricity as inputs, Twelve transforms captured carbon dioxide into essential products such as methane, ethylene, and ethanol. The firm aims to provide a cost-competitive alternative to petroleum-derived chemicals and fuels, thereby addressing carbon emissions while simultaneously creating economically viable solutions.

Tidal Metals developed a breakthrough suite of innovations for producing critical minerals and metals from seawater and brines – with no waste, no carbon emissions, and no harm to the environment.

SyntaxBio develops CRISPR/Cas9-based, genetic programming platform that converts cells into biological computers using DNA-based instructions that read like lines of code. SyntaxBio's platform can program cells without the need for consistent external intervention.

Noetik is an AI-native biotechnology company focused on the discovery and development of cancer immunotherapies. Utilizing advanced machine learning techniques, Noetik's platform identifies new therapeutic targets and designs innovative treatments. By harnessing self-supervised learning and integrating diverse human multimodal data, the company aims to enhance the precision and effectiveness of immunotherapies. This approach enables the development of more personalized cancer treatments, contributing to the advancement of targeted therapies in oncology.

Unspun, Inc. is a digital apparel company based in San Francisco, California, founded in 2015. It specializes in creating custom jeans tailored to individual consumers using advanced body scanning technology, fit algorithms, and additive manufacturing. The company aims to address environmental challenges by minimizing pattern-cutting waste and unsold inventory, thus contributing to a reduction in global carbon emissions. Unspun's innovative approach enables on-demand production of jeans in under ten minutes, utilizing localized manufacturing processes designed to be zero-waste. Its technology has gained recognition, including being named one of TIME's Best Inventions of 2019, and supports a B2B platform that facilitates digital customization for major apparel brands.

ZwitterCo specializes in advanced membrane solutions for the treatment of highly impaired wastewater, enabling the reuse and recycling of water resources in industrial applications. The company's innovative reverse osmosis and nanofiltration technologies address the challenges of treating historically unfilterable streams by preventing fouling caused by organic molecules. ZwitterCo's membranes are chlorine-tolerant, back-washable, and resistant to irreversible fouling, which enhances their longevity and performance. By transforming wastewater from a liability into a valuable resource, ZwitterCo helps clients manage their water treatment needs more economically and sustainably, reducing chemical demands and improving operational efficiency.

Samsara Eco is an innovative enviro-tech company that employs enzymatic technology to recycle plastic waste indefinitely. Its proprietary process breaks down plastics into reusable components, enabling manufacturers to produce new plastic items and fostering a circular loop for plastics, thereby reducing waste and dependence on fossil fuels.

Valar Labs, founded in 2021 by Anirudh Joshi, Viswesh Krishna, Pranav Rajpurkar, and Damir Vrabac, is a healthcare technology company focused on enhancing cancer treatment through the use of artificial intelligence. The company has developed a software platform that analyzes imaging data, which is routinely collected in clinical settings, to provide oncologists with interpretable and actionable insights. By leveraging patient-specific characteristics, Valar Labs aims to support oncologists in making informed treatment decisions, ultimately improving patient outcomes in cancer care.

Latus Bio is a biotechnology company dedicated to developing innovative gene therapies for neurological diseases. It specializes in novel discovery approaches using non-human primate models, enabling precise delivery of therapeutic genes to targeted cells within the central nervous system. Latus Bio aims to enhance clinical safety and manufacturing efficiency by administering low doses of its proprietary adeno-associated virus (AAV) capsids.

Relation Therapeutics is a biotechnology company focused on advancing drug discovery and development. It utilizes human genetics and clinical omics data, alongside patient-derived tissue samples, to identify and validate therapeutic programs. The company employs machine learning to explore the relationships between genes, proteins, and drugs, generating insights that have real translational validity. By combining single-cell multi-omics from patient tissues with functional assays, Relation Therapeutics aims to deepen the understanding of biological processes in human health and disease. This approach enables healthcare providers to discover and develop novel treatments, particularly in areas with unmet medical needs.

Founded in 2017, Fervo Energy specializes in developing and operating geothermal assets using proprietary technology. Based in San Francisco, the company generates clean power through innovative geoscience methods, aiming to provide a dispatchable foundation for a 100% clean energy future.

Frontier Medicines Corporation, established in 2018 and headquartered in South San Francisco, California, is a pre-clinical stage biopharmaceutical company specializing in cancer research. The company employs chemoproteomics to discover and develop novel medicines targeting cancer-causing proteins. Frontier Medicines' innovative platform integrates advanced computational methods and machine learning algorithms to identify and pharmacologically target new binding pockets on proteins, thereby enabling small-molecule drug discovery and development for previously inaccessible targets.

Insight M specializes in developing innovative aerial monitoring technology focused on methane detection for the energy sector. Utilizing a combination of physical science expertise and advanced data analytics, the company surveys extensive areas and generates digital maps using optical and infrared wavelengths. This technology allows Insight M to meticulously scan pipelines and vast territories to pinpoint significant sources of gas loss. By facilitating comprehensive data collection about both the natural environment and human infrastructure, Insight M aims to enhance operational efficiency and safety within the oil and gas industry. Notably, the company carried out the first-ever basin-wide aerial survey for methane detection in the Permian Basin in 2019, underscoring its commitment to improving methane management practices.

Unlearn.AI, Inc. is a biotechnology company based in San Francisco, California, that specializes in developing innovative software tools for clinical research. Established in 2017, Unlearn.AI focuses on enhancing clinical trials through its unique digital twin technology, known as TwinRCT. This approach utilizes machine learning to create prognostic digital twins for individual patients, allowing for more accurate estimations of treatment effects while reducing the number of participants needed. The company also offers services for Clinical Trial Design, which helps determine inclusion criteria, endpoints, and study sizes, as well as Synthetic Control Arms that can minimize or eliminate the need for concurrent control groups. Additionally, Unlearn.AI provides Subgroup Analysis to identify and analyze specific patient subgroups within trial results. By integrating expertise from pharmaceuticals, medical technology, and machine learning, Unlearn.AI aims to transform clinical trials to improve outcomes for both patients and sponsors.

Elo Life Systems is a biotechnology company dedicated to enhancing human health through innovative food solutions. It aims to bridge gaps between food, agriculture, and health by partnering with stakeholders across the food systems value chain. Elo employs precision breeding technologies, genomics, data analytics, machine learning, and gene editing capabilities to develop healthier, more sustainable food options.

Equilibrium Energy specializes in optimizing energy consumption and reducing costs through its advanced energy management platform. The company aims to facilitate sustainable practices, enhance efficiency for power companies, and contribute positively to the environment.

Totus Medicines is a biotechnology company focused on developing innovative therapies for diseases that have been historically difficult to treat. Utilizing advanced chemical biology techniques, the company employs a proprietary platform that enables high-throughput screening of billions of drug candidates against numerous biological targets. This approach allows Totus Medicines to identify effective molecules for traditionally challenging conditions, including cancer, Alzheimer's disease, infectious diseases, and age-related disorders. By harnessing the potential of covalent bonding and cutting-edge drug discovery methods, Totus Medicines aims to translate genetic insights into viable therapeutic options, addressing unmet medical needs across the human genome.

Fourth Power specializes in utility-scale thermal battery storage solutions. It converts renewable energy into a reliable on-demand power source, addressing grid needs while facilitating the transition to decarbonized infrastructure.

Reality Defender specializes in detecting deepfakes and AI-generated media across various formats such as audio, video, images, and text. Its patented multimodal approach enables real-time detection of advanced impersonations, helping mitigate risks associated with manipulated content. The platform offers flexible deployment options that integrate smoothly into existing infrastructure.

Relay specializes in business automation technology aimed at enhancing team productivity and efficiency. By providing a platform that establishes and streamlines core workflows, Relay enables organizations to automate routine tasks and improve coordination among team members. This approach allows leaders to manage their teams more effectively, ensuring that workflows are executed on time and reducing the burden of tedious coordination. Through its solutions, Relay supports enterprises in achieving better alignment and operational effectiveness.

Mach Industries specializes in developing advanced technology solutions for defense systems. The company focuses on producing and combusting hydrogen from field-sourced materials, aiming to enhance global security and supply chain resiliency.

Noetik is an AI-native biotechnology company focused on the discovery and development of cancer immunotherapies. Utilizing advanced machine learning techniques, Noetik's platform identifies new therapeutic targets and designs innovative treatments. By harnessing self-supervised learning and integrating diverse human multimodal data, the company aims to enhance the precision and effectiveness of immunotherapies. This approach enables the development of more personalized cancer treatments, contributing to the advancement of targeted therapies in oncology.

CH4 Global Inc. is a holding company focused on producing seaweed bio-products aimed at reducing methane emissions from livestock, particularly ruminants such as cows, goats, sheep, and deer. Founded in 2019 and based in San Francisco, California, the company specializes in Asparagopsis armata, a seaweed supplement proven to decrease enteric methane emissions by up to 90%. CH4 Global operates through subsidiaries in the United States, Australia, New Zealand, and the Pacific, leveraging established scientific and technological methods to develop innovative livestock feed additives. The company aims to mitigate greenhouse gas emissions on a large scale, supporting both environmental sustainability and economic benefits for farmers and food producers through potential carbon credits and premium pricing for their products.

Verdigris Technologies develops software solutions for real-time electricity monitoring in commercial facilities. Its key product, Verdigris Energy Tracker, identifies operational inefficiencies, automates building management, predicts and reduces peak demand, and detects equipment failures. The system uses wireless hardware to send device-level consumption data to the cloud, enabling smarter facility operations, energy efficiency, and property management.

Radionetics Oncology is a biopharmaceutical company dedicated to the discovery and development of innovative radiotherapeutics aimed at treating various oncology indications. The company specializes in creating non-peptide and small molecule therapies that facilitate the targeted delivery of therapeutic radioisotopes to solid tumors. By focusing on these advanced treatment options, Radionetics Oncology seeks to enhance the effectiveness of cancer therapies and improve patient outcomes in oncology care.

Solu Therapeutics is a precision medicine company developing therapeutics focused on eliminating disease-driving cells. Its platform combines selective small-molecule binders with proprietary antibodies to create bifunctional therapeutics, targeting inflammatory and autoimmune diseases.

Plotlogic Pty Ltd is an Australian technology company specializing in ore characterization systems for the mining sector. Based in Brisbane and established in 2005, it employs advanced hyperspectral imaging and AI-driven platforms to enable mine operators to accurately identify the location and material properties of every rock in the mine. Its key products include OreSense LV, which assesses deviations from geological models; OreBlocks, an API for optimizing the planning process; and OreCheck, which delivers real-time alerts to fluctuations in ore quality. The company aims to enhance yield in critical mineral extraction while promoting sustainable mining practices by improving ore recovery, minimizing dilution, and reducing carbon emissions. Plotlogic also offers tailored on-site and off-site support services to ensure effective use of its technologies across various commodities, including coal, iron ore, and gold.

Our full-stack tech­nol­o­gy plat­form brings micro­bio­me drug dis­cov­ery into focus. Our spa­tial map­ping dis­cov­ery engine pro­vides stun­ning pic­tures of the inter­ac­tions and con­nec­tions between host and the micro­bio­me; an area of this vital sys­tem that we’ve nev­er been able to com­plete­ly under­stand before. Spa­tial biol­o­gy of the host-micro­bio­me inter­face pro­vides new oppor­tu­ni­ties for effec­tive ther­a­peu­tic inter­ven­tions, ulti­mate­ly enabling us to bet­ter treat patients.

Nium is a climate technology company focused on decarbonizing industry through innovative nanotechnology. The company has developed a nanocatalyst reactor that facilitates the on-site synthesis of ammonia, utilizing renewable energy sources. This system, known as Green Ammonia on Demand, allows for the decentralized production of ammonia, which can be stored and transported efficiently. By integrating its reactor with hydrogen-producing facilities, Nium aims to significantly reduce carbon dioxide emissions, thereby helping industries lower their carbon footprints and contribute to a more sustainable economy.

Founded in 2021, Demox Labs specializes in developing a decentralized oracle protocol that connects smart contracts to off-chain data sources. Its platform bridges the gap between web2 and web3, unlocking online data for smart contract development.

Auradine specializes in web infrastructure solutions for blockchain, security, and privacy. It offers software, hardware, and cloud services designed for scalability, sustainability, and security.

Ascend Gene & Cell Therapies supports manufacturing and process development projects from design through to clinical and commercial scales. They partner with biotechnology teams to embed scalable manufacturing in their operations from the beginning. They respond to customer inquiries by phone and contact form.

Charlie is the new standard for 62+ banking* services. Charlie helps retirees make the most of their limited resources with features including faster access to their Social Security check, competitive earnings on deposits, no monthly fees or minimums, US-based customer service, and a simple, transparent digital experience designed for their needs. Charlie is transforming financial assistance for the 62+ community and providing peace of mind around their financial present and future. Charlie is not a bank, banking services provided by Sutton Bank; Member FDIC. To learn more, visit Charlie.com.

NinjaTech AI develops an artificial intelligence platform that offers comprehensive digital assistance. Its platform integrates features like image and video generation, editing, code generation, writing assistance, research functionalities, scheduling, external AI model access, file analysis, and prompt engineering tools. This enables businesses and individuals to accomplish tasks efficiently and economically.

Halter Limited, founded in 2016 and based in Morrinsville, New Zealand, specializes in developing GPS-enabled, solar-powered tracking devices for livestock. The company manufactures innovative collars designed for cows, allowing farmers to monitor and guide their animals across pastures. Halter's technology enables virtual fencing, helping farmers optimize productivity while promoting sustainable farming practices. By enhancing the management of livestock, Halter aims to improve agricultural efficiency and animal welfare, contributing to the overall sustainability of pasture-based farming.

Amogy specializes in developing carbon-free energy solutions for hard-to-abate sectors such as maritime, power generation, and heavy industry. Its patented ammonia cracking technology converts liquid ammonia into electrical power using hydrogen fuel cells.

Shennon Biotechnologies focuses on the analysis and manipulation of immune cells at the single-cell level to enhance the development of treatments for human diseases, particularly cancer. Utilizing a proprietary single-cell platform, the company profiles millions of immune cells simultaneously, allowing for the identification of rare and difficult-to-find targets that are crucial for advancing immunotherapy. By addressing a significant bottleneck in the field of immunotherapy, Shennon Biotechnologies aims to enable the creation of more targeted and effective immunotherapies, thereby contributing to improved therapeutic outcomes in the medical industry.

Founded in 2012, Mythic specializes in designing and manufacturing AI-driven silicon chips and inference processors. Its innovative technology brings desktop GPU compute capabilities and neural networks to compact, energy-efficient devices, enabling AI deployment across various industries such as consumer electronics, wearables, and autonomous systems.

Fulfil Solutions is a developer of advanced robotic automation technology aimed at transforming the online grocery sector. The company specializes in creating a fully automated fulfillment system designed to enhance profitability while addressing food supply chain challenges. By integrating mechanical design, software, robotics, computer vision, and deep learning, Fulfil Solutions offers solutions that streamline picking, packing, and inventory control across various product categories and temperature zones. Their innovative technology seeks to reduce waste, minimize environmental impact, and lower emissions, enabling companies to automate their supply chain processes effectively within a compact operational footprint. Through these advancements, Fulfil Solutions supports sustainable and customer-centric online grocery operations at scale.

Aquafortus specializes in non-thermal crystallization technology aimed at recovering clean water and crystallizing salts from high-salinity brines. The company addresses the treatment needs of various industries, including cooling towers, mining, oil and gas, inland desalination, and flue gas desulfurization from power generation. By significantly reducing energy consumption, Aquafortus enhances the economic viability of liquid transportation, wastewater management, and zero liquid discharge processes. This innovative approach enables clients to lower their operating expenses while effectively managing high-salinity waste.

Fortem Technologies, Inc. is a privately held company based in Provo, Utah, specializing in AI-enabled airspace security and safety solutions. Founded in 2016, Fortem develops and manufactures advanced intrusion detection and detect-and-avoid systems that alert, identify, and classify drones and other unmanned aerial vehicles (UAVs). Its product offerings include various radar systems, such as the DAA-R10 and DAA-R20, designed for mission-critical operations and compliance with FAA standards. Additionally, the company provides the ThreatAware AI analysis engine, which processes data from multiple sensors in real-time, and the F700 Patriot, a multi-rotor drone platform. Fortem's DroneHunter, a military-tested unmanned aircraft, is designed for perimeter intrusion detection and protection. Through its innovative technologies, Fortem enables organizations to enhance operational safety and transition unmanned aircraft operations beyond visual line of sight (BVLOS).

Elo Life Systems is a biotechnology company dedicated to enhancing human health through innovative food solutions. It aims to bridge gaps between food, agriculture, and health by partnering with stakeholders across the food systems value chain. Elo employs precision breeding technologies, genomics, data analytics, machine learning, and gene editing capabilities to develop healthier, more sustainable food options.

Founded in 2015, Evonetix develops innovative technology for parallel DNA synthesis on silicon arrays, facilitating synthetic biology research. Based in Little Chesterford, UK, the company combines scientific and engineering expertise to advance DNA synthesis capabilities.

Recycleye Limited, founded in London in 2019 by Victor Dewulf, develops AI-powered machine learning tools for waste management. These tools facilitate waste characterization, tracking, and automated sorting, empowering users to transition towards a more circular economy efficiently.

Nest Genomics is a lab-agnostic, comprehensive software solution for implementing genomic programs at scale.

BurnBot specializes in wildfire mitigation and vegetation management services. It combines expertise in forestry with advanced fire technology to systematically treat fuel sources, preventing destructive wildfires.

Reach designs and delivers long-range wireless power networks that provide scalable and resilient energy infrastructure. Its system transfers power wirelessly, analogous to how Wi-Fi delivers data, through patented technologies such as high-efficiency power beaming circuits, network optimization algorithms, and adaptive electromagnetic surfaces. The platform is designed to be safe, scalable, and easy to use for a range of industries, including manufacturing, government, energy, logistics, and retail. By using radio frequency transmission, its solutions rely on proprietary antenna structures, converter designs, and system architectures to power devices without cables, enabling operations that are not constrained by traditional wiring.

Verdant Robotics, Inc., founded in 2018 and based in Hayward, California, specializes in artificial intelligence-driven robotic solutions for agriculture. The company develops advanced technologies that enable farmers to digitally map their fields and monitor each plant's health over time. Verdant's flagship product, the Model B Smart Sprayer, significantly reduces labor costs by over 50% and input costs by up to 96% while providing precise weeding and thinning for various crop types. Utilizing proprietary Bullseye targeting technology and a Pinpoint Spray System, Verdant promotes micro-fertilization and nutrient delivery, enhancing crop yields and efficiency. By leveraging robotics, computer vision, and machine learning, Verdant Robotics empowers growers of all sizes to optimize production and improve profitability in the agricultural sector.

Smartex focuses on addressing significant challenges in the textile industry by leveraging advanced AI technology, specifically machine learning and computer vision. The company has developed a hardware-enabled software solution that detects textile defects and irregularities in real time. By implementing this innovative system, Smartex can halt production when defects are identified, thereby minimizing defective output and reducing textile waste. This proactive approach not only enhances production efficiency but also contributes to sustainability by lowering carbon dioxide emissions, energy consumption, and water usage. Moreover, Smartex provides factories with a user interface to monitor production statistics, further improving operational insights and decision-making capabilities.

Samsara Eco is an innovative enviro-tech company that employs enzymatic technology to recycle plastic waste indefinitely. Its proprietary process breaks down plastics into reusable components, enabling manufacturers to produce new plastic items and fostering a circular loop for plastics, thereby reducing waste and dependence on fossil fuels.

ZwitterCo specializes in advanced membrane solutions for the treatment of highly impaired wastewater, enabling the reuse and recycling of water resources in industrial applications. The company's innovative reverse osmosis and nanofiltration technologies address the challenges of treating historically unfilterable streams by preventing fouling caused by organic molecules. ZwitterCo's membranes are chlorine-tolerant, back-washable, and resistant to irreversible fouling, which enhances their longevity and performance. By transforming wastewater from a liability into a valuable resource, ZwitterCo helps clients manage their water treatment needs more economically and sustainably, reducing chemical demands and improving operational efficiency.

Novome Biotechnologies, Inc. is a biotechnology company specializing in the engineering of gut bacteria to create innovative therapies for chronic diseases. Established in 2015 and located in South San Francisco, California, Novome has developed a pioneering platform for the controlled colonization of the gut with genetically engineered microbial medicines (GEMMs). This platform allows for the precise delivery of therapeutic activities aimed at treating conditions such as hyperoxaluria, with a focus on creating a bacterial strain that can degrade oxalate to help prevent kidney stone formation. The company is also expanding its synthetic biology capabilities to explore additional therapeutic indications, aiming to improve long-term health outcomes for patients through its living therapeutics.

Founded in 2017, Fervo Energy specializes in developing and operating geothermal assets using proprietary technology. Based in San Francisco, the company generates clean power through innovative geoscience methods, aiming to provide a dispatchable foundation for a 100% clean energy future.

Auron Therapeutics is a biotechnology company focused on cancer therapy development that seeks to change the paradigm from tumor cell killing to differentiation therapy, aiming to transform malignant cells into normal functioning cells by reactivating endogenous cellular programs. The company uses platforms that integrate large-omic datasets and miniaturized high-throughput flow cytometry to rapidly identify and validate multiple targets and drugs in primary human patient samples. This approach is designed to advance therapeutic candidates for cancer across areas of unmet medical need and to support the development of transformative medicines. Auron Therapeutics was founded in 2018 and is based in Wellesley, Massachusetts.

Twelve is a company that focuses on providing innovative cashless payment solutions tailored for various industries, including sports, events, catering, and museums. The company has developed a user-friendly online cash register and payment system designed primarily for sports clubs, which facilitates point-of-sale transactions and supports digital pricing along with debit and credit payments. Twelve aims to enhance the payment experience for clients by offering software modules, ordering solutions, and communication tools, thereby helping entrepreneurs and organizers achieve greater success in their initiatives.

Sabanto is a company that offers a Farming-as-a-Service solution aimed at enhancing autonomy in agricultural machinery. It specializes in low-cost retrofitting of existing agricultural equipment, irrespective of brand or model, and develops software that supports the functionality of autonomous technology. This approach not only improves the utility of farming equipment but also aims to increase the return on investment for producers. Sabanto's technology facilitates comprehensive agricultural services through a supervised autonomous equipment platform, allowing farmers to monitor and operate their operations efficiently from a centralized location. By focusing on simple and cost-effective innovations, Sabanto is dedicated to advancing the future of agriculture.

Twelve, formerly known as Opus 12, is a Berkeley, California-based company that specializes in recycling carbon dioxide emissions into valuable chemicals and fuels. Founded in 2015, the company has developed innovative technology that can be integrated with any source of CO₂ emissions. By utilizing only water and electricity as inputs, Twelve transforms captured carbon dioxide into essential products such as methane, ethylene, and ethanol. The firm aims to provide a cost-competitive alternative to petroleum-derived chemicals and fuels, thereby addressing carbon emissions while simultaneously creating economically viable solutions.

Relation Therapeutics is a biotechnology company focused on advancing drug discovery and development. It utilizes human genetics and clinical omics data, alongside patient-derived tissue samples, to identify and validate therapeutic programs. The company employs machine learning to explore the relationships between genes, proteins, and drugs, generating insights that have real translational validity. By combining single-cell multi-omics from patient tissues with functional assays, Relation Therapeutics aims to deepen the understanding of biological processes in human health and disease. This approach enables healthcare providers to discover and develop novel treatments, particularly in areas with unmet medical needs.

Zap Energy, Inc. is a Seattle-based company that specializes in the design and manufacture of sheared-flow stabilized Z-Pinch fusion reactors for power generation. Founded in 2017, the company focuses on developing compact and scalable fusion technology that offers low-carbon, cost-effective, and flexible energy solutions. Unlike conventional fusion methods, Zap Energy's approach utilizes electric current to create magnetic fields that confine and compress plasma, enhancing the stability and efficiency of the fusion process. This innovative technology aims to provide sustainable energy while requiring less capital investment compared to traditional fusion systems.

Sickbay is a healthcare services company that specializes in patient monitoring and analytics. Founded in 1999, Sickbay offers a software platform designed to assist healthcare professionals by providing comprehensive access to patient data, including medical histories and real-time monitoring from various devices. Its solutions focus on automating documentation and improving alarm management, which helps reduce unnecessary alarm noise and ensures that care providers receive pertinent alerts. Additionally, Sickbay engages in the wholesale marketing of FDA-authorized nutritional supplements, aimed at supporting hospital professionals and medical staff in delivering informed, data-driven patient care.

Zeno Power is a company that creates advanced power systems that use radioisotopes. The company intends to increase the production of small-scale nuclear batteries capable of powering spacecraft and undersea technologies for years. Zeno, founded in 2018 by three Vanderbilt University students, intends to be the first to enter the commercial market with a novel new combination of affordability and lightweight.

Capella Space is an information services company based in San Francisco that operates a constellation of small satellites equipped with synthetic aperture radar, delivering on-demand, high-resolution radar imagery of the Earth's surface. The SAR imagery can be acquired through clouds, smoke, fog, and darkness, enabling continuous global monitoring and rapid insight across industries. Capella's services support infrastructure monitoring, agriculture, disaster response, maritime domain awareness, city planning and mapping, and business intelligence, helping customers detect sub-meter surface changes, track economic activity, and monitor environmental and security-related conditions. Founded in 2016, Capella Space provides timely earth observation for commerce, conservation, and safety.

Agility Robotics specializes in developing robotic machines with human-like mobility. Its flagship product is Cassie, a bipedal robot designed for walking and running. The company's legged robots serve as mobile sensor platforms, enabling real-time sensing across diverse terrains. Agility Robotics caters to academic, corporate, and military research and development sectors.

Unlearn.AI, Inc. is a biotechnology company based in San Francisco, California, that specializes in developing innovative software tools for clinical research. Established in 2017, Unlearn.AI focuses on enhancing clinical trials through its unique digital twin technology, known as TwinRCT. This approach utilizes machine learning to create prognostic digital twins for individual patients, allowing for more accurate estimations of treatment effects while reducing the number of participants needed. The company also offers services for Clinical Trial Design, which helps determine inclusion criteria, endpoints, and study sizes, as well as Synthetic Control Arms that can minimize or eliminate the need for concurrent control groups. Additionally, Unlearn.AI provides Subgroup Analysis to identify and analyze specific patient subgroups within trial results. By integrating expertise from pharmaceuticals, medical technology, and machine learning, Unlearn.AI aims to transform clinical trials to improve outcomes for both patients and sponsors.

Aclarity, LLC is a United States-based manufacturer specializing in innovative water purification devices for residential use. Founded in 2017, the company develops advanced electrochemical water treatment systems that effectively eliminate contaminants such as pathogens, metals, volatile organic compounds (VOCs), per- and polyfluoroalkyl substances (PFAS), and ammonia from water. Aclarity's patented technology aims to provide cost-effective, low-maintenance solutions for comprehensive water treatment, catering to the growing need for clean water and addressing pollution challenges in both water and wastewater systems. As a venture capital-backed cleantech startup, Aclarity is focused on revolutionizing the water treatment industry with its cutting-edge approach.

zkLend is a Layer 2 money-market protocol developed on StarkNet that leverages zk-rollup technology to enhance transaction speed and reduce costs while maintaining the security of the Ethereum network. The platform is designed to facilitate decentralized financial transactions, allowing users to engage in money-market activities without compromising their privacy. By combining the scalability advantages of zk-rollups with Ethereum's robust security features, zkLend aims to provide an efficient and secure environment for users in the decentralized finance space.

Brimstone develops a carbon-negative process for producing ordinary portland cement and supplementary cementitious material. Its technology uses calcium silicate rock instead of limestone, delivering identical products at scale while significantly reducing CO2 emissions.

Plotlogic Pty Ltd is an Australian technology company specializing in ore characterization systems for the mining sector. Based in Brisbane and established in 2005, it employs advanced hyperspectral imaging and AI-driven platforms to enable mine operators to accurately identify the location and material properties of every rock in the mine. Its key products include OreSense LV, which assesses deviations from geological models; OreBlocks, an API for optimizing the planning process; and OreCheck, which delivers real-time alerts to fluctuations in ore quality. The company aims to enhance yield in critical mineral extraction while promoting sustainable mining practices by improving ore recovery, minimizing dilution, and reducing carbon emissions. Plotlogic also offers tailored on-site and off-site support services to ensure effective use of its technologies across various commodities, including coal, iron ore, and gold.

Creyon Bio is a pre-clinical stage company focused on advancing drug development through a data-driven methodology. It specializes in engineering RNA-based medicines and their components by creating proprietary datasets that inform advanced machine learning models. This innovative approach enables the rapid identification of design rules and engineering principles necessary for the development of safe and effective oligonucleotide-based medicines. By leveraging these insights, Creyon Bio aims to improve the efficiency of the drug development process, ultimately contributing to cost savings in the healthcare sector while catering to diverse patient populations.

Rill Data is a business intelligence platform that simplifies analytics by combining a SQL-based data modeler, an in-memory real-time database, and a metrics dashboard into a single product. It enables real-time operational dashboards and metrics-first modeling for data-driven decisions, allowing analytics teams, product managers, and finance professionals to explore time-series data, monitor costs, and optimize campaigns. The platform supports BI-as-code and deployment workflows to accelerate the path from data to dashboards, offering a faster, easier alternative to complex BI stacks.

Remedy Robotics is a developer of innovative remote-controlled endovascular robots aimed at improving access to medical interventions worldwide. The company specializes in automating the procedure of mechanical thrombectomy, a crucial treatment for stroke patients. By enhancing the efficiency and effectiveness of endovascular interventions, Remedy Robotics seeks to ensure timely care, ultimately reducing the risk of severe disabilities resulting from strokes. Through its advancements in robotic technology, the company is committed to transforming the landscape of emergency medical care.

Amogy specializes in developing carbon-free energy solutions for hard-to-abate sectors such as maritime, power generation, and heavy industry. Its patented ammonia cracking technology converts liquid ammonia into electrical power using hydrogen fuel cells.

Totus Medicines is a biotechnology company focused on developing innovative therapies for diseases that have been historically difficult to treat. Utilizing advanced chemical biology techniques, the company employs a proprietary platform that enables high-throughput screening of billions of drug candidates against numerous biological targets. This approach allows Totus Medicines to identify effective molecules for traditionally challenging conditions, including cancer, Alzheimer's disease, infectious diseases, and age-related disorders. By harnessing the potential of covalent bonding and cutting-edge drug discovery methods, Totus Medicines aims to translate genetic insights into viable therapeutic options, addressing unmet medical needs across the human genome.

Petra is a robotics company specializing in underground utility solutions. The firm has developed advanced tunneling robots designed to efficiently and safely bore utility conduits through various geological conditions, including high-grade hard rock. By enabling the undergrounding of critical utilities, Petra provides a practical and cost-effective means to construct small-diameter infrastructure, particularly in disaster-prone areas. Their technology addresses the challenges of traditional tunneling methods, making it feasible to install essential utilities in previously inaccessible locations.

Q-CTRL develops software tools and firmware for quantum computing to reduce and control quantum bit errors in quantum hardware. Its quantum control infrastructure software supports research and development professionals and end users, accelerating the pathway to the first useful quantum computers and underpinning software-defined quantum sensors for defence, intelligence, navigation, and earth observation. The company collaborates with universities, national labs, and industry partners to advance hardware error management and stability in quantum systems.

nTopology, Inc. is an engineering software company founded in 2013 and headquartered in New York, New York. The company specializes in developing design software and tools aimed at optimizing manufacturing processes. Its flagship platform, nTopology, empowers engineers to create lightweight and optimized parts that meet specific functional requirements. The software includes features such as Lightweighting, Architected Materials, Topology Optimization, Additive Manufacturing, and Design Analysis, facilitating the integration of geometry and simulation data into manufacturing-ready models. By streamlining workflows and enhancing team collaboration, nTopology serves a diverse range of industries, including aerospace and defense, medical, automotive, consumer products, and education.

Founded in 2020, Kettle is a technology-driven reinsurer based in Bermuda. It employs proprietary deep learning algorithms to analyze vast amounts of satellite, weather, and ground truth data, enabling more accurate risk predictions and reducing loss ratios for insurance companies.

Gradle Inc. is a company that specializes in enhancing developer productivity through its innovative software solutions, notably Develocity, which was formerly known as Gradle Enterprise. The firm is also the creator of the widely used open-source Gradle Build Tool, which sees over 30 million downloads each month. Gradle is at the forefront of Developer Productivity Engineering (DPE), a practice adopted by prominent organizations such as Airbnb, LinkedIn, Microsoft, Nasdaq, and Netflix. These elite teams utilize Develocity’s advanced technologies and analytics to accelerate build and test performance, thereby improving the reliability of their developer toolchains and streamlining the troubleshooting of failures. By automating and unifying the build processes, Gradle enables enterprises to effectively build, deliver, and maintain complex applications, thereby enhancing their capability to ship software efficiently and cost-effectively.

StarkWare Industries Ltd is a technology company based in Netanya, Israel, established in 2017. The company specializes in developing software and hardware solutions focused on the generation and verification of computational integrity proofs. Its primary offering, known as STARK, is a zero-knowledge proof protocol that enhances privacy in blockchain applications, increases transaction throughput, and enables off-chain computation. StarkWare Industries aims to create a comprehensive proof stack to facilitate secure and efficient computational processes across various applications.

Jupiter Intelligence, Inc. is a technology company that specializes in climate risk analytics, providing tools and platforms to assess the impacts of weather and climate change. Founded in 2017 and based in San Mateo, California, Jupiter offers the ClimateScore Intelligence Platform, which utilizes cloud computing to integrate various predictive models that process data from numerous ground-based and satellite sensors. The company's offerings include Jupiter FloodScore, which assists users in preparing for potential flooding, and Jupiter HeatScore, which predicts extreme temperatures to help organizations mitigate heat- and cold-related risks. By transforming complex climate science into actionable data, Jupiter enables businesses to proactively manage and disclose climate risks, helping them navigate the increasing frequency and severity of extreme weather events.

TrustPoint is developing a next-generation GPS signal processing technology to provide the performance and reliability required for safety-critical automation, vital infrastructure, and seamless augmented reality.

MosaicML is a company focused on creating an efficient infrastructure for training large language models and improving the overall efficiency of neural networks. It develops software and artificial intelligence training algorithms that enhance the training process by utilizing algorithmic techniques such as sparsity and network pruning. These innovations allow users to effectively and securely train large-scale AI models on their proprietary data, while also optimizing for speed, quality, and cost. MosaicML aims to streamline the machine learning model recomposition process, making it easier for organizations to harness the power of AI in their operations.

Kentik is a network observability company that provides a real-time, cloud-based platform for planning, operating, and optimizing complex networks. Its Network Observability Cloud unifies cloud, device, flow, and synthetic data to deliver actionable insights, fast search, and AI-driven analytics for IT and network engineers. The core product, Kentik Detect, is a SaaS solution that enables visibility, performance monitoring, anomaly detection including DDoS, capacity planning, and optimization for enterprises, service providers, and cloud environments. The company also offers self-service analytics via My Kentik and an AIOps platform for network operations, along with additional capabilities for visibility, alerting, planning, and open integrations. Kentik serves organizations across financial services, media, hosting and cloud infrastructure, research and education, digital enterprises, carriers, CDNs, and ISPs, helping them improve operational efficiency, protect services, and support scalable application delivery.

CH4 Global Inc. is a holding company focused on producing seaweed bio-products aimed at reducing methane emissions from livestock, particularly ruminants such as cows, goats, sheep, and deer. Founded in 2019 and based in San Francisco, California, the company specializes in Asparagopsis armata, a seaweed supplement proven to decrease enteric methane emissions by up to 90%. CH4 Global operates through subsidiaries in the United States, Australia, New Zealand, and the Pacific, leveraging established scientific and technological methods to develop innovative livestock feed additives. The company aims to mitigate greenhouse gas emissions on a large scale, supporting both environmental sustainability and economic benefits for farmers and food producers through potential carbon credits and premium pricing for their products.