DCVC

Founded in 2011, DCVC is a venture capital firm based in Palo Alto, California. The firm invests in early-stage companies utilizing deep tech to solve complex problems across sectors such as artificial intelligence, exascale computing, climate, engineering, materials science, robotics, space, water, biology, defense, and security.

Jack Buendorf

Associate

Andy May

Operating Partner

Patrick McCauley

Operating Partner

Matt O'Connell

Operating Partner

Matt Ocko

Co-Managing Partner and Co-Founder

Past deals in Chemical

AgZen

Series A in 2025
AgZen is a company that specializes in the development of pesticide sprays designed to adhere to plants, thereby minimizing pollution associated with agricultural chemicals. The firm provides patented, field-tested food-safe additives and sprayer retrofits that enhance the adhesion of agrochemical droplets to crops. This innovative approach allows farmers to achieve effective protection while significantly reducing the volume of pesticides used, without sacrificing plant health or yield. By focusing on sustainability and efficiency, AgZen aims to support agricultural practices that are both environmentally friendly and economically viable for farmers.

Twelve

Series C in 2024
Twelve, formerly known as Opus 12, is a Berkeley, California-based company that specializes in recycling carbon dioxide emissions into valuable chemicals and fuels. Founded in 2015, the company has developed innovative technology that can be integrated with any source of CO₂ emissions. By utilizing only water and electricity as inputs, Twelve transforms captured carbon dioxide into essential products such as methane, ethylene, and ethanol. The firm aims to provide a cost-competitive alternative to petroleum-derived chemicals and fuels, thereby addressing carbon emissions while simultaneously creating economically viable solutions.

Totus Medicines

Series B in 2023
Totus Medicines is a biotechnology company focused on developing innovative therapies for diseases that have been historically difficult to treat. Utilizing advanced chemical biology techniques, the company employs a proprietary platform that enables high-throughput screening of billions of drug candidates against numerous biological targets. This approach allows Totus Medicines to identify effective molecules for traditionally challenging conditions, including cancer, Alzheimer's disease, infectious diseases, and age-related disorders. By harnessing the potential of covalent bonding and cutting-edge drug discovery methods, Totus Medicines aims to translate genetic insights into viable therapeutic options, addressing unmet medical needs across the human genome.

Twelve

Series B in 2022
Twelve, formerly known as Opus 12, is a Berkeley, California-based company that specializes in recycling carbon dioxide emissions into valuable chemicals and fuels. Founded in 2015, the company has developed innovative technology that can be integrated with any source of CO₂ emissions. By utilizing only water and electricity as inputs, Twelve transforms captured carbon dioxide into essential products such as methane, ethylene, and ethanol. The firm aims to provide a cost-competitive alternative to petroleum-derived chemicals and fuels, thereby addressing carbon emissions while simultaneously creating economically viable solutions.

Totus Medicines

Series A in 2021
Totus Medicines is a biotechnology company focused on developing innovative therapies for diseases that have been historically difficult to treat. Utilizing advanced chemical biology techniques, the company employs a proprietary platform that enables high-throughput screening of billions of drug candidates against numerous biological targets. This approach allows Totus Medicines to identify effective molecules for traditionally challenging conditions, including cancer, Alzheimer's disease, infectious diseases, and age-related disorders. By harnessing the potential of covalent bonding and cutting-edge drug discovery methods, Totus Medicines aims to translate genetic insights into viable therapeutic options, addressing unmet medical needs across the human genome.

Trident Desal

Seed Round in 2021
Trident Desal is a pioneering developer of temperature swing solvent extraction (TSSE) desalination technology. This innovative process uses low-grade thermal heat to treat high-salinity water cost-effectively, addressing the challenge of toxic brine waste common in traditional desalination methods. Trident's system employs a proprietary solvent that selectively attracts and separates brine from freshwater when heated, allowing for its reuse in subsequent cycles.

Twelve

Series A in 2021
Twelve, formerly known as Opus 12, is a Berkeley, California-based company that specializes in recycling carbon dioxide emissions into valuable chemicals and fuels. Founded in 2015, the company has developed innovative technology that can be integrated with any source of CO₂ emissions. By utilizing only water and electricity as inputs, Twelve transforms captured carbon dioxide into essential products such as methane, ethylene, and ethanol. The firm aims to provide a cost-competitive alternative to petroleum-derived chemicals and fuels, thereby addressing carbon emissions while simultaneously creating economically viable solutions.
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