Alaska Permanent Fund

Kenai Therapeutics specializes in developing innovative therapies for neurodegenerative movement disorders. The company focuses on providing off-the-shelf neuron replacement medicines as effective disease-modifying treatments, enabling doctors to employ new techniques for treating neurological conditions such as Parkinson's.

NorthLink Aviation is a developer and operator of air cargo terminals focused on enhancing airport infrastructure to meet the increasing demand for trans-Pacific cargo transportation. Holding a long-term lease for the 120-acre South Park Campus, the company is dedicated to constructing essential facilities that support cargo airlines in their operations between Asia and North America. By providing infrastructure services that facilitate safe and efficient refueling, deicing, and cargo exchange, NorthLink Aviation aims to streamline the logistics for air carriers and accommodate the growing volumes of cargo at Anchorage International Airport.

Generate Biomedicines, Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing innovative therapeutics through its pioneering platform in Generative Biology. Established in 2018, the company utilizes machine learning to analyze existing proteins, enabling it to understand the principles governing the relationship between genetic sequences and protein structure. This approach facilitates the invention of novel antibodies, peptides, enzymes, receptors, and other protein-based therapeutics optimized for specific biological functions. By harnessing its advanced technology, Generate Biomedicines aims to accelerate drug discovery by generating new biological molecules with significant therapeutic potential. Originally known as Generate Biologics, the company adopted its current name in March 2020 to reflect its expanded focus on biomedicine.

Repertoire Immune Medicines, Inc. is a clinical stage biotechnology company based in Cambridge, Massachusetts, founded in 2016. The company focuses on harnessing the power of T cells to develop innovative treatments for cancer, autoimmune diseases, and infectious diseases. By utilizing autologous T cells that are primed against specific cancer antigens and tethered to IL-15, Repertoire Immune Medicines aims to unlock and direct the human immune system to effectively prevent and treat various conditions. The company also specializes in characterizing T cell receptor (TCR)-antigen pairs and rationally designing targeted immune medicines, thereby enhancing the potential for effective therapies in serious health challenges.

Tessera Therapeutics is an early-stage life sciences company focused on pioneering Gene Writing technology, which allows for the precise insertion of therapeutic messages into the human genome. This innovative approach aims to address diseases at their source by enabling both small and large genetic alterations. By building on recent advancements in gene therapy and gene editing, Tessera Therapeutics seeks to overcome existing limitations in these fields, enhancing their efficacy and reach. Founded by Flagship Pioneering, the company aspires to establish a new category in genetic medicine that can significantly improve patient outcomes and transform healthcare.

Indigo is an agricultural technology company dedicated to enhancing the sustainability and productivity of agriculture through its expertise in plant microbiomes. By leveraging a database of genomic microbe information, Indigo identifies and applies beneficial microbes to crops, primarily through seed coatings. This approach not only helps optimize plant health and yields but also aims to improve farmer profitability. Additionally, Indigo is committed to addressing broader agricultural challenges by promoting practices that reduce reliance on water, nitrogen fertilizers, and pesticides. Through these innovations, Indigo seeks to better serve the needs of farmers and consumers alike, contributing to the capacity to feed a growing global population while fostering sustainable farming practices.

Founded in 2018, Sana Biotechnology focuses on creating and delivering engineered cells as medicine for patients. The company aims to reprogram cells in the body or replace damaged ones to treat a broad range of diseases, with a pipeline including SC291, SC262, SC255, UP421, and other candidates across therapeutic areas like oncology, diabetes, autoimmune disorders, and CNS.

Indigo is an agricultural technology company dedicated to enhancing the sustainability and productivity of agriculture through its expertise in plant microbiomes. By leveraging a database of genomic microbe information, Indigo identifies and applies beneficial microbes to crops, primarily through seed coatings. This approach not only helps optimize plant health and yields but also aims to improve farmer profitability. Additionally, Indigo is committed to addressing broader agricultural challenges by promoting practices that reduce reliance on water, nitrogen fertilizers, and pesticides. Through these innovations, Indigo seeks to better serve the needs of farmers and consumers alike, contributing to the capacity to feed a growing global population while fostering sustainable farming practices.

Codiak BioSciences is a clinical-stage biopharmaceutical company dedicated to developing exosome-based therapeutics, a novel class of medicines with the potential to address various diseases with significant unmet medical needs. The company employs its proprietary engEx Platform, which allows for the engineering and manufacturing of exosomes, leveraging their natural role as intercellular messengers. Codiak's pipeline includes product candidates such as exoSTING and exoIL-12, targeting diverse therapeutic areas including oncology, neuro-oncology, neurology, neuromuscular diseases, and infectious diseases. Additionally, the company collaborates with the Ragon Institute to explore the potential of its exoVACC platform for vaccines against SARS-CoV-2 and HIV. Founded in 2015 and headquartered in Cambridge, Massachusetts, Codiak aims to transform therapeutic approaches by harnessing the unique properties of exosomes.

Indigo is an agricultural technology company dedicated to enhancing the sustainability and productivity of agriculture through its expertise in plant microbiomes. By leveraging a database of genomic microbe information, Indigo identifies and applies beneficial microbes to crops, primarily through seed coatings. This approach not only helps optimize plant health and yields but also aims to improve farmer profitability. Additionally, Indigo is committed to addressing broader agricultural challenges by promoting practices that reduce reliance on water, nitrogen fertilizers, and pesticides. Through these innovations, Indigo seeks to better serve the needs of farmers and consumers alike, contributing to the capacity to feed a growing global population while fostering sustainable farming practices.

Denali Therapeutics is a biopharmaceutical company dedicated to discovering and developing therapies for neurodegenerative diseases such as Alzheimer's, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). The company is advancing several therapeutic candidates, including LRRK2 inhibitors like DNL201 and DNL151 for Parkinson's disease, and DNL747, a RIPK1 inhibitor targeting Alzheimer's and ALS. Denali's innovative approaches also include enzyme replacement therapy for MPS II and antibody transport vehicle programs aimed at addressing alpha-synuclein and Tau pathology. Established in 2013 and headquartered in South San Francisco, California, Denali collaborates with notable organizations including Takeda, Genentech, and the Michael J. Fox Foundation to leverage research and development in the field of neurodegeneration. The company aims to translate scientific insights into effective treatments, contributing to the ongoing effort to combat these debilitating conditions.

Indigo is an agricultural technology company dedicated to enhancing the sustainability and productivity of agriculture through its expertise in plant microbiomes. By leveraging a database of genomic microbe information, Indigo identifies and applies beneficial microbes to crops, primarily through seed coatings. This approach not only helps optimize plant health and yields but also aims to improve farmer profitability. Additionally, Indigo is committed to addressing broader agricultural challenges by promoting practices that reduce reliance on water, nitrogen fertilizers, and pesticides. Through these innovations, Indigo seeks to better serve the needs of farmers and consumers alike, contributing to the capacity to feed a growing global population while fostering sustainable farming practices.

Codiak BioSciences is a clinical-stage biopharmaceutical company dedicated to developing exosome-based therapeutics, a novel class of medicines with the potential to address various diseases with significant unmet medical needs. The company employs its proprietary engEx Platform, which allows for the engineering and manufacturing of exosomes, leveraging their natural role as intercellular messengers. Codiak's pipeline includes product candidates such as exoSTING and exoIL-12, targeting diverse therapeutic areas including oncology, neuro-oncology, neurology, neuromuscular diseases, and infectious diseases. Additionally, the company collaborates with the Ragon Institute to explore the potential of its exoVACC platform for vaccines against SARS-CoV-2 and HIV. Founded in 2015 and headquartered in Cambridge, Massachusetts, Codiak aims to transform therapeutic approaches by harnessing the unique properties of exosomes.

Denali Therapeutics is a biopharmaceutical company dedicated to discovering and developing therapies for neurodegenerative diseases such as Alzheimer's, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). The company is advancing several therapeutic candidates, including LRRK2 inhibitors like DNL201 and DNL151 for Parkinson's disease, and DNL747, a RIPK1 inhibitor targeting Alzheimer's and ALS. Denali's innovative approaches also include enzyme replacement therapy for MPS II and antibody transport vehicle programs aimed at addressing alpha-synuclein and Tau pathology. Established in 2013 and headquartered in South San Francisco, California, Denali collaborates with notable organizations including Takeda, Genentech, and the Michael J. Fox Foundation to leverage research and development in the field of neurodegeneration. The company aims to translate scientific insights into effective treatments, contributing to the ongoing effort to combat these debilitating conditions.

Juno Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing innovative cell-based immunotherapies for cancer treatment. Utilizing chimeric antigen receptor (CAR) and T cell receptor (TCR) technologies, Juno engineers T cells to target and eliminate cancer cells. The company's product pipeline includes several promising candidates, such as JCAR017, in Phase I/II trials for relapsed or refractory non-Hodgkin lymphoma and acute lymphoblastic leukemia, as well as JCAR018 for pediatric patients with CD22-positive cancers. Other candidates target various malignancies, including neuroblastoma, lung cancer, ovarian cancer, and glioblastoma. Juno collaborates with leading cancer research institutions to advance its therapies and was founded in 2013, headquartered in Seattle, Washington. In 2018, Juno became a subsidiary of Bristol-Myers Squibb Company.

Juno Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing innovative cell-based immunotherapies for cancer treatment. Utilizing chimeric antigen receptor (CAR) and T cell receptor (TCR) technologies, Juno engineers T cells to target and eliminate cancer cells. The company's product pipeline includes several promising candidates, such as JCAR017, in Phase I/II trials for relapsed or refractory non-Hodgkin lymphoma and acute lymphoblastic leukemia, as well as JCAR018 for pediatric patients with CD22-positive cancers. Other candidates target various malignancies, including neuroblastoma, lung cancer, ovarian cancer, and glioblastoma. Juno collaborates with leading cancer research institutions to advance its therapies and was founded in 2013, headquartered in Seattle, Washington. In 2018, Juno became a subsidiary of Bristol-Myers Squibb Company.