In an industry that critically needs innovation, we are constantly impressed by the potential of the Ultrasound Localization Microscopy (ULM) technology to solve medical challenges. Building a technology that can unlock so many possibilities is the adventure of a lifetime. We know the road ahead will be full of ups and downs. But that makes us even more determined to succeed and make life-changing / saving discoveries possible. The development of Ultrasound Localization Microscopy (ULM) could widen applications for microvascular imaging by improving contrast, resolution, and penetration depth. Microbubbles, a contrast agent already clinically used to improve conventional ultrasound imaging, are injected into the blood flow and localized thanks to the ultrasound technology to reconstruct the microvessels. Building on the first results of 3D ULM with small animals in 2018 in Olivier Couture’s Laboratory, Resolve is developing an ultrasound device based on ULM technology to image micro-vessels in 3 dimensions within minutes, allowing its use by many healthcare professionals. Our core technology has already demonstrated its viability in 2D in humans with very high definition images of micro-vessels through the human skull and in 3D in vitro. We focus our development toward the application of 3D ULM for non-invasive stroke diagnosis.The first studies show the relevance of such imaging for the early diagnosis of stroke in humans by volumetric ULM, without the constraints and availability of MRI and CT. By targeting stroke first, we hope to have an impact on millions of people, as stroke is considered the second leading cause of death worldwide. Such an imaging device leading to a significant reduction in death and disability thanks to pre-hospital/hospital management of stroke opens a large market.