Grifols is a global healthcare company based in Spain, primarily engaged in the research, development, production, and commercialization of plasma-derived products. It operates through three main segments: Bioscience, Hospital, and Diagnostic. The Bioscience segment is focused on plasma derivative production, significantly bolstered by the acquisition of Talecris in 2011 and Biotest in 2022, which together enhanced its product portfolio and contributed to a substantial portion of its sales. The Hospital segment provides critical products and services to healthcare facilities, while the Diagnostic segment specializes in the development and manufacturing of diagnostic tools for laboratory analysis, particularly aimed at blood banks and transfusion centers. In 2023, the biopharma business comprised 84% of Grifols' sales, with diagnostics accounting for approximately 10%.
Biotest is a specialized company focused on innovative haematology, clinical immunology, and intensive care medicine. It develops, manufactures, and markets plasma proteins and biotherapeutic drugs, with a value chain that encompasses pre-clinical and clinical development to global marketing and distribution. The company produces immunoglobulins, clotting factors, and albumins derived from human blood plasma, processed in advanced fractionation facilities in Europe. Additionally, Biotest develops monoclonal antibodies targeting conditions such as plasma cell cancer and systemic lupus erythematosus through recombinant technologies. The majority of its revenue is generated from its Therapy segment, with significant operations in Central Europe and other regions. Biotest employs over 2,500 people worldwide and focuses on creating effective medications for life-threatening diseases, including blood coagulation disorders, severe infections, and immune system disorders.
Prometic Plasma Resources
Acquisition in 2022
Prometic Plasma Resources is a healthcare center that specializes in blood donation services.
GigaGen
Acquisition in 2021
GigaGen, Inc. is a biopharmaceutical company focused on developing innovative antibody therapies for cancer and immune deficiencies. Founded in 2010 and based in South San Francisco, California, GigaGen employs advanced technologies such as microfluidics, bioinformatics, sequencing, and genetic engineering to analyze B and T cell repertoires. This enables the identification of full-length, natively paired antibodies and T cell receptors. The company is advancing a pipeline that includes novel oncology antibody drug combinations and the first recombinant polyclonal hyperimmune gammaglobulin. GigaGen's proprietary discovery technology allows for the rapid characterization of cells within complex immune systems, which facilitates the selection of drug targets and the identification of potential drug candidates, ultimately enhancing preclinical efficacy assessments.
Alkahest
Acquisition in 2020
Alkahest, Inc. is a clinical stage biopharmaceutical company based in San Carlos, California, founded in 2014. The company focuses on developing therapies derived from blood to address neurological diseases, particularly those associated with aging, such as Alzheimer’s disease and Parkinson’s disease. Alkahest's research has revealed that factors present in the blood plasma of younger mice can potentially reverse cognitive deficits in aging and Alzheimer’s disease models. Collaborating with Grifols, a global healthcare company known for its plasma therapies, Alkahest aims to enhance health and vitality through innovative treatments that target the effects of aging.
MedKeeper
Acquisition in 2018
MedKeeper develops mobile and web-based software applications that enhance efficiency and compliance in hospital pharmacy operations. Their suite of secure, hosted applications is utilized by numerous hospitals and medical centers to facilitate communication, ensure compliance, and boost productivity within pharmacy settings. The software provides features such as real-time reporting and analytics, workflow management, inspections, medication tracking, and quality assurance. By leveraging technology, MedKeeper enables healthcare institutions to improve their operational processes and maintain high standards of service in pharmacy management.
GigaGen
Funding Round in 2017
GigaGen, Inc. is a biopharmaceutical company focused on developing innovative antibody therapies for cancer and immune deficiencies. Founded in 2010 and based in South San Francisco, California, GigaGen employs advanced technologies such as microfluidics, bioinformatics, sequencing, and genetic engineering to analyze B and T cell repertoires. This enables the identification of full-length, natively paired antibodies and T cell receptors. The company is advancing a pipeline that includes novel oncology antibody drug combinations and the first recombinant polyclonal hyperimmune gammaglobulin. GigaGen's proprietary discovery technology allows for the rapid characterization of cells within complex immune systems, which facilitates the selection of drug targets and the identification of potential drug candidates, ultimately enhancing preclinical efficacy assessments.
Hologic - NAT donor screening unit
Acquisition in 2017
Hologic - NAT donor screening unit engages in research, development and manufacture of assays and instruments based on NAT (Nucleic Acid Testing) technology for transfusion and transplantation screening
Singulex
Funding Round in 2016
Singulex, Inc. is an immunodiagnostics and biotechnology company that specializes in single molecule counting (SMC) technology for clinical diagnostics and scientific research. The company has developed the Sgx Clarity System, an in vitro diagnostics platform capable of detecting low abundance biomarkers at levels down to femtograms/mL. This system assists clinicians in managing cardiovascular health, while also providing heart disease monitoring services and personalized wellness programs for patients. Singulex's offerings include ultra-sensitive immunoassay solutions and laboratory testing services that facilitate both reactive and proactive health management, as well as support the discovery of new therapeutics. The company serves a diverse clientele, including pharmaceutical research laboratories, clinical research organizations, and academic institutions globally. Additionally, Singulex is involved in pilot studies to validate its Erenna BioAssay System, which enhances molecular detection capabilities. Founded in 1997 and based in Alameda, California, Singulex has an additional office in Basel, Switzerland, and was previously known as BioProfile Corporation until its name change in 2003.
Alkahest
Corporate Round in 2015
Alkahest, Inc. is a clinical stage biopharmaceutical company based in San Carlos, California, founded in 2014. The company focuses on developing therapies derived from blood to address neurological diseases, particularly those associated with aging, such as Alzheimer’s disease and Parkinson’s disease. Alkahest's research has revealed that factors present in the blood plasma of younger mice can potentially reverse cognitive deficits in aging and Alzheimer’s disease models. Collaborating with Grifols, a global healthcare company known for its plasma therapies, Alkahest aims to enhance health and vitality through innovative treatments that target the effects of aging.
Kiro Robotics
Acquisition in 2014
Kiro Robotics is a technology company that specializes in the automation of machinery for the hospital sector. It concentrates on developing machines and equipment to automate and control key points of hospital processes, and hospital pharmacy processes in particular, improving the safety of patients and health professionals alike, and delivering increased efficiency.
Celyad
Venture Round in 2013
Celyad is a biopharmaceutical company, specialized in cell therapy. It develops technologies and treatments to treat severe diseases with poor prognosis. The company focuses on Immuno oncology, Cardiology, and Medical devices. Its main product candidates include CAR-T NKR-2, C-Cure. The firm has CYAD-01, CYAD-02, CYAD-03 programs in pipeline. The company owns trademarks and service marks including CELYAD, C-CATH, C_CURE, CATH and C-CATHez and CARDIO 3 BIOSCIENCES. The firm has Cardiology and Immuno-oncology operating segments.
Progenika Biopharma
Acquisition in 2013
Progenika Biopharma is a biotechnology company located in Derio, Spain, specializing in the development, production, and commercialization of molecular biology tests. The company focuses on blood group genotyping, diagnosing complex genetic diseases, and monitoring health conditions. Progenika Biopharma designs in vitro diagnostic tests that address a wide array of clinical needs, including tools for disease diagnosis and prognosis, as well as predicting patient responses to drug treatments. Through its innovative solutions, Progenika Biopharma aims to enhance healthcare outcomes by providing precise and reliable diagnostic information.
VCN Biosciences
Funding Round in 2012
VCN Biosciences is focused on researching and developing innovative treatments for tumors, particularly those that lack effective therapies. The company utilizes a specialized technological platform based on oncolytic adenoviruses, which are designed to selectively replicate and amplify within tumor cells. This approach aims to provide new therapeutic options for challenging cases, such as refractory tumors like pancreatic adenocarcinomas, thereby enhancing treatment possibilities for healthcare institutions.
Araclon Biotech
Acquisition in 2012
Araclon Biotech is a biotechnology company focused on the research and development of diagnostic methods and therapies for degenerative diseases, particularly Alzheimer's disease. The company specializes in creating tests for analyzing β-amyloid peptides in human plasma, which are crucial for the early diagnosis of the disease. In addition to diagnostic tools, Araclon Biotech is also engaged in developing immunotherapy vaccines aimed at targeting β-amyloid peptides, thereby helping to prevent or delay the onset of Alzheimer's symptoms. The company is involved in the scientific investigation, creation, and commercialization of pharmacological and biotechnological products, utilizing both its own and external patents in the field.
Talecris Biotherapeutics
Acquisition in 2010
Talecris Biotherapeutics is a biopharmaceutical company based in Barcelona, Spain, specializing in the production and marketing of plasma-derived protein therapies. Founded in 2004, the company develops and distributes a range of therapies aimed at treating individuals with chronic and acute immune deficiency disorders, alpha-1 antitrypsin deficiency, infectious diseases, hemophilia, and severe burns. Talecris offers hyperimmune therapies, which include antibody preparations for diseases such as hepatitis, rabies, and tetanus, as well as treatments for Rh-negative pregnant women carrying Rh-positive children. Additionally, the company provides albumin products under various brand names, including Plasbumin and Plasmanate, along with plasma-derived hemostasis products designed to assist patients lacking necessary clotting factors.
Celyad
Series B in 2009
Celyad is a biopharmaceutical company, specialized in cell therapy. It develops technologies and treatments to treat severe diseases with poor prognosis. The company focuses on Immuno oncology, Cardiology, and Medical devices. Its main product candidates include CAR-T NKR-2, C-Cure. The firm has CYAD-01, CYAD-02, CYAD-03 programs in pipeline. The company owns trademarks and service marks including CELYAD, C-CATH, C_CURE, CATH and C-CATHez and CARDIO 3 BIOSCIENCES. The firm has Cardiology and Immuno-oncology operating segments.
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