Harbour BioMed
Harbour Biomed is a biotechnology company focused on developing therapeutics for cancer and inflammatory diseases, with a particular emphasis on immuno-oncology. Founded in 2016 and headquartered in Shanghai, China, the company utilizes proprietary transgenic mouse platforms to discover and develop fully human monoclonal antibodies and heavy chain only antibodies. These platforms facilitate the creation of bispecific antibodies and other innovative therapeutic compounds. Harbour Biomed also collaborates with various institutions, including The Wistar Institute and WuXi Biologics, and has strategic partnerships with entities like Sichuan Kelun-Biotech and Hualan Genetic Engineering. The company’s development pipeline includes multiple products aimed at treating conditions such as autoimmune diseases and COVID-19. With operational bases in Cambridge, Massachusetts, and Rotterdam, the Netherlands, Harbour Biomed aims to advance drug discovery and therapeutic development in key global markets.
Harbour Antibodies BV, established in 2006 and based in Rotterdam, Netherlands, specializes in the production of antibodies and VH domains for therapeutic applications. The company utilizes advanced transgenic mouse technology to engineer mice capable of generating high affinity human antibodies. It has developed two key types of human immunoglobulin gene transgenic mice: those that produce conventional tetrameric antibodies, known as H2L2 antibodies, which consist of two heavy and two light chains, and those that generate heavy chain-only antibodies (HCAbs), which lack light chains. The availability of HCAbs allows for the generation of soluble human VH domains, facilitating the creation of innovative multi-functional molecules. Harbour Antibodies' transgenic mouse lines are accessible to licensing partners, enhancing research and development in the field of antibody therapeutics. The company operates as a subsidiary of Harbour BioMed.
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