Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company focuses on developing innovative solutions for stroke detection. Its flagship product, AlphaStroke, is a non-invasive, AI-powered device designed for medical personnel to identify strokes in various environments, even before advanced imaging techniques like CT or MRI are available. This portable and durable device can detect both ischemic and hemorrhagic strokes, enabling practitioners to triage patients effectively and improve treatment outcomes. By streamlining the decision-making process in stroke management, AlphaStroke aims to reduce delays in critical care and enhance the overall frequency of stroke treatments.
Neuro Kinetics, Inc. specializes in eye tracking technology and non-invasive neuro-otologic diagnostic testing tools, catering to audiologists, ENT specialists, neuro-otologists, neuro-ophthalmologists, and neurologists globally. Founded in 1984 and based in Pittsburgh, Pennsylvania, the company offers a range of products designed to assist medical professionals in diagnosing various diseases and conditions. Key offerings include the I-PORTAL Neuro-Otologic Test Center, which serves as a comprehensive testing solution, and the VEST software for neuro-otologic analysis. Additional products include the I-Portal Video Nystagmography and I-Portal Video Oculography systems, which facilitate vestibular diagnostics and eye tracking tests. Neuro Kinetics also provides maintenance, training, support services, and various accessories to enhance the functionality of its diagnostic tools. As of September 2019, Neuro Kinetics operates as a subsidiary of Neurolign Technologies Inc.
Clinical Platform creates short form, video based patient and caregiver information for people that have cancer and then connects them to clinical trials. The purpose of our business is to improve the outcomes of cancer patients by providing easily accessible and retain-able information on the diagnosis of, treatments for and living with and any type of cancer. It is a fact that better educated patients have improved outcomes.
Clinical Platform creates short form, video based patient and caregiver information for people that have cancer and then connects them to clinical trials. The purpose of our business is to improve the outcomes of cancer patients by providing easily accessible and retain-able information on the diagnosis of, treatments for and living with and any type of cancer. It is a fact that better educated patients have improved outcomes.
Clinical Platform creates short form, video based patient and caregiver information for people that have cancer and then connects them to clinical trials. The purpose of our business is to improve the outcomes of cancer patients by providing easily accessible and retain-able information on the diagnosis of, treatments for and living with and any type of cancer. It is a fact that better educated patients have improved outcomes.
Carmell Therapeutics Corporation, founded in 2007 and based in Pittsburgh, Pennsylvania, specializes in the production of plasma-based biologically-active plastic medical devices designed for the treatment of bone and connective tissue injuries. The company utilizes proprietary technology developed in collaboration with Carnegie Mellon University and Allegheny General Hospital to manufacture these sterile, off-the-shelf products. Their offerings include REPAIR bone putty, which is used to fill bone defects, and a surgical scaffold that facilitates the healing of injured tendons and ligaments. These products are engineered to promote tissue healing by leveraging the body’s own growth and regenerative factors, ensuring favorable mechanical properties that align with the repaired tissue. Carmell Therapeutics primarily targets the sports medicine market, aiming to enhance clinical outcomes for patients with connective tissue injuries.
Ariel Precision Medicine is an integrated genomics and digital health company based in Pittsburgh, Pennsylvania, that focuses on providing precision medicine solutions for the diagnosis, monitoring, and treatment of complex chronic diseases. Founded in 2013, the company develops innovative clinical decision support tools designed to simplify personalized treatment, particularly through its flagship product, ArielDx. This cloud-based platform specifically aids in the diagnosis and management of pancreatic disease, enhancing the capabilities of healthcare providers in both emergency and clinical settings. Ariel Precision Medicine aims to improve patient outcomes by leveraging advanced technology and genomic insights in healthcare.
Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company focuses on developing innovative solutions for stroke detection. Its flagship product, AlphaStroke, is a non-invasive, AI-powered device designed for medical personnel to identify strokes in various environments, even before advanced imaging techniques like CT or MRI are available. This portable and durable device can detect both ischemic and hemorrhagic strokes, enabling practitioners to triage patients effectively and improve treatment outcomes. By streamlining the decision-making process in stroke management, AlphaStroke aims to reduce delays in critical care and enhance the overall frequency of stroke treatments.
Better Body Image, Inc. is a company based in Pittsburgh, Pennsylvania, that specializes in developing a mobile application aimed at promoting health and fitness. The application, known as Better Body Image, uses proprietary data to create personalized exercise routines tailored to individual body types, activity levels, and overall goals. A key feature of the app is its patented AI technology, which allows users to visualize their appearance at their target weight, thereby enhancing motivation towards achieving fitness objectives. In collaboration with AI Ventures, the company aims to expand its reach globally, targeting one million downloads shortly after the app's launch. Better Body Image is dedicated to helping individuals manage their health and fitness journeys, leveraging a body change database that addresses chronic conditions based on waist size and body measurements.
Medrobotics Corporation is a medical robotics company based in Raynham, Massachusetts, specializing in the development and commercialization of the Flex Robotic System. This innovative platform features a steerable and shapeable robotic scope that allows surgeons to navigate complex anatomy through a single, small entry point, addressing hard-to-reach areas that traditional rigid surgical tools cannot access. The Flex Robotic System is complemented by a suite of specialized instruments, including laser holders and various monopolar tools, designed for applications such as transoral robotic surgery and transoral laser microsurgery. Established in 2005 and previously known as Cardiorobotics, Inc., Medrobotics has a strong presence in the European market, focusing on enhancing minimally invasive surgical techniques and improving patient access to advanced surgical procedures.
Carmell Therapeutics Corporation, founded in 2007 and based in Pittsburgh, Pennsylvania, specializes in the production of plasma-based biologically-active plastic medical devices designed for the treatment of bone and connective tissue injuries. The company utilizes proprietary technology developed in collaboration with Carnegie Mellon University and Allegheny General Hospital to manufacture these sterile, off-the-shelf products. Their offerings include REPAIR bone putty, which is used to fill bone defects, and a surgical scaffold that facilitates the healing of injured tendons and ligaments. These products are engineered to promote tissue healing by leveraging the body’s own growth and regenerative factors, ensuring favorable mechanical properties that align with the repaired tissue. Carmell Therapeutics primarily targets the sports medicine market, aiming to enhance clinical outcomes for patients with connective tissue injuries.
Cernostics, Inc. is a diagnostics company based in Pittsburgh, Pennsylvania, specializing in cancer diagnostics and prognostics through a tissue systems biology approach. Founded in 2008, Cernostics develops the TissueCypher Barrett’s esophagus assay, which utilizes whole slide digital imaging technology to assess the risk for patients with Barrett’s esophagus, thereby reducing uncertainty in treatment decisions for gastroenterologists. The company's patent-protected TissueCypher platform analyzes whole slide digital images using multiplexed fluorescence, enhancing the accuracy of traditional tissue diagnostics by evaluating tumors as complex systems comprised of multiple cell types. Additionally, Cernostics operates a high-complexity clinical reference laboratory that supports biomarker discovery, validation, and clinical trial efforts, ultimately aiming to improve patient outcomes and reduce healthcare costs. The company has established a strategic collaboration with Deciphex Limited to further its capabilities in spatial biology and AI-driven image analytics.
Cognition Therapeutics, Inc. is a clinical-stage neuroscience company based in Pittsburgh, Pennsylvania, focused on developing small molecule therapeutics aimed at addressing neurodegenerative and neuro-ophthalmic disorders. Founded in 2007, the company is notable for its drug candidate CT1812, an oral brain-penetrant molecule designed to restore cellular processes disrupted by diseases such as Alzheimer’s and dry age-related macular degeneration. Cognition Therapeutics targets the toxic proteins that contribute to cognitive decline, a key factor in various degenerative diseases of the brain. The company employs proprietary assays and medicinal chemistry to create novel, high-quality drug candidates, addressing an unmet need in the treatment of these complex conditions.
Complexa, Inc. is a biopharmaceutical company based in Berwyn, Pennsylvania, focused on developing innovative treatments for severe diseases involving fibrosis and inflammation. Founded in 2008, Complexa specializes in the research and development of endogenous human cell signaling technologies, particularly through the synthesis of endogenous nitro-fatty acids. Their lead compound, CXA-10, is an oral nitrated fatty acid being developed for the treatment of focal segmental glomerulosclerosis and pulmonary arterial hypertension. The company aims to enhance existing anti-inflammatory and metabolic signaling pathways to promote recovery from acute and chronic tissue injuries and diseases, targeting a range of inflammatory, fibrotic, and central nervous system disorders.
ALung Technologies, Inc. is a medical device company based in Pittsburgh, Pennsylvania, specializing in the development and manufacturing of devices for treating acute respiratory failure. The company's primary product, the Hemolung Respiratory Assist System, serves as a dialysis-like alternative to mechanical ventilation by removing carbon dioxide and delivering oxygen directly into the blood. This technology allows patients' lungs to rest and recover while avoiding the need for intubation and enabling protective ventilation. In addition to the Hemolung system, ALung Technologies also develops the Hattler Catheter, which facilitates extracorporeal gas exchange by circulating blood through a small catheter inserted into the central venous bloodstream. Founded in 1997, the company focuses on innovative solutions for both acute and chronic respiratory disorders.
ATRP SOLUTIONS develops and manufactures specialty polymers that meet their needs. It recognizes the polymeric materials for improving the performance of commercial products in the areas of personal care and cosmetics, detergents and surfactants, paints, pigments, coatings, and biocompatible materials. It was founded in 2006 and is headquartered in Pittsburgh, Pennsylvania.
Cognition Therapeutics, Inc. is a clinical-stage neuroscience company based in Pittsburgh, Pennsylvania, focused on developing small molecule therapeutics aimed at addressing neurodegenerative and neuro-ophthalmic disorders. Founded in 2007, the company is notable for its drug candidate CT1812, an oral brain-penetrant molecule designed to restore cellular processes disrupted by diseases such as Alzheimer’s and dry age-related macular degeneration. Cognition Therapeutics targets the toxic proteins that contribute to cognitive decline, a key factor in various degenerative diseases of the brain. The company employs proprietary assays and medicinal chemistry to create novel, high-quality drug candidates, addressing an unmet need in the treatment of these complex conditions.
ClearCount Medical Solutions specializes in patient safety solutions for the operating room, focusing on the prevention of medical errors. The company has developed an innovative sponge management system that integrates counting and detection capabilities, enhancing surgical efficiency and patient safety. Utilizing radio frequency identification (RFID) technology, ClearCount's platform enables quick reconciliation of sponge counts during procedures. In cases where a count does not reconcile, the SmartWand™ device assists in locating any missing sponges, further minimizing risks associated with retained surgical items. Through these advancements, ClearCount Medical Solutions aims to improve operational efficiency in surgical environments while ensuring better outcomes for patients.
Quantum OPS is an orthopedic technology company focused on developing innovative equipment to improve patient mobility and outcomes in surgical settings. The company offers a range of products, including a shoulder positioning system and a carbon operative arm positioner, along with various accessories designed for head and body support. These products enable clinicians, orthopedic surgeons, nurses, and anesthesiologists to effectively immobilize, stabilize, and position patients of all sizes during shoulder surgery. Quantum OPS emphasizes user involvement throughout the design process, ensuring that the needs of operating room professionals are met while maintaining agility and responsiveness to market demands.
Complexa, Inc. is a biopharmaceutical company based in Berwyn, Pennsylvania, focused on developing innovative treatments for severe diseases involving fibrosis and inflammation. Founded in 2008, Complexa specializes in the research and development of endogenous human cell signaling technologies, particularly through the synthesis of endogenous nitro-fatty acids. Their lead compound, CXA-10, is an oral nitrated fatty acid being developed for the treatment of focal segmental glomerulosclerosis and pulmonary arterial hypertension. The company aims to enhance existing anti-inflammatory and metabolic signaling pathways to promote recovery from acute and chronic tissue injuries and diseases, targeting a range of inflammatory, fibrotic, and central nervous system disorders.
Medrobotics Corporation is a medical robotics company based in Raynham, Massachusetts, specializing in the development and commercialization of the Flex Robotic System. This innovative platform features a steerable and shapeable robotic scope that allows surgeons to navigate complex anatomy through a single, small entry point, addressing hard-to-reach areas that traditional rigid surgical tools cannot access. The Flex Robotic System is complemented by a suite of specialized instruments, including laser holders and various monopolar tools, designed for applications such as transoral robotic surgery and transoral laser microsurgery. Established in 2005 and previously known as Cardiorobotics, Inc., Medrobotics has a strong presence in the European market, focusing on enhancing minimally invasive surgical techniques and improving patient access to advanced surgical procedures.
Quantum OPS is an orthopedic technology company focused on developing innovative equipment to improve patient mobility and outcomes in surgical settings. The company offers a range of products, including a shoulder positioning system and a carbon operative arm positioner, along with various accessories designed for head and body support. These products enable clinicians, orthopedic surgeons, nurses, and anesthesiologists to effectively immobilize, stabilize, and position patients of all sizes during shoulder surgery. Quantum OPS emphasizes user involvement throughout the design process, ensuring that the needs of operating room professionals are met while maintaining agility and responsiveness to market demands.
Carmell Therapeutics Corporation, founded in 2007 and based in Pittsburgh, Pennsylvania, specializes in the production of plasma-based biologically-active plastic medical devices designed for the treatment of bone and connective tissue injuries. The company utilizes proprietary technology developed in collaboration with Carnegie Mellon University and Allegheny General Hospital to manufacture these sterile, off-the-shelf products. Their offerings include REPAIR bone putty, which is used to fill bone defects, and a surgical scaffold that facilitates the healing of injured tendons and ligaments. These products are engineered to promote tissue healing by leveraging the body’s own growth and regenerative factors, ensuring favorable mechanical properties that align with the repaired tissue. Carmell Therapeutics primarily targets the sports medicine market, aiming to enhance clinical outcomes for patients with connective tissue injuries.
Cognition Therapeutics, Inc. is a clinical-stage neuroscience company based in Pittsburgh, Pennsylvania, focused on developing small molecule therapeutics aimed at addressing neurodegenerative and neuro-ophthalmic disorders. Founded in 2007, the company is notable for its drug candidate CT1812, an oral brain-penetrant molecule designed to restore cellular processes disrupted by diseases such as Alzheimer’s and dry age-related macular degeneration. Cognition Therapeutics targets the toxic proteins that contribute to cognitive decline, a key factor in various degenerative diseases of the brain. The company employs proprietary assays and medicinal chemistry to create novel, high-quality drug candidates, addressing an unmet need in the treatment of these complex conditions.
Rinovum Women's Health, Inc. develops medical devices for women. It offers Stork, a medical device that aids in natural fertility and conception in the privacy of home.
STARR Life Sciences Corp. specializes in the development and manufacture of research equipment for small animals, catering to life science laboratories globally. The company's product lineup includes the MouseOX Plus, a pulse oximeter that measures critical physiological parameters such as heart rate, arterial oxygen saturation, breath rate, and temperature in both anesthetized and conscious mice and rats. Additionally, STARR offers the E-Mitter Telemetry System, which enables continuous monitoring of small animals' temperature, motor activity, and heart rate, along with various related components like telemetry implants and data analysis software. Their product range also encompasses running wheels, activity cage systems, and infrared motion sensors specifically designed for rats and mice. STARR Life Sciences serves a diverse clientele, including researchers and veterinarians from universities, pharmaceutical companies, and contract research organizations. Founded in 2004, the company is headquartered in Oakmont, Pennsylvania.
Applied Computational Technologies is a software development company that specializes in applications for the life sciences, particularly in radiation treatment planning for cancer therapy. With a significant number of cancer diagnoses in the United States, a large portion of patients undergo radiation treatment, highlighting the importance of effective planning tools. The company's flagship product, ProACTive, serves as a dose calculation engine that facilitates adaptive radiotherapy, enhancing the precision and effectiveness of cancer treatment. Through its innovative software solutions, Applied Computational Technologies aims to improve patient outcomes in the challenging field of oncology.
NeuroInterventional Therapeutics, Inc. ("NIT", dba Neurointerventions, Inc.) is a Pittsburgh-based company which designs and manufactures advanced catheter systems used to find, trap, and extract thrombus ("blood clots") in a wide range of cerebral vessels, thereby increasing chances of survival and minimizing disability.
Cernostics, Inc. is a diagnostics company based in Pittsburgh, Pennsylvania, specializing in cancer diagnostics and prognostics through a tissue systems biology approach. Founded in 2008, Cernostics develops the TissueCypher Barrett’s esophagus assay, which utilizes whole slide digital imaging technology to assess the risk for patients with Barrett’s esophagus, thereby reducing uncertainty in treatment decisions for gastroenterologists. The company's patent-protected TissueCypher platform analyzes whole slide digital images using multiplexed fluorescence, enhancing the accuracy of traditional tissue diagnostics by evaluating tumors as complex systems comprised of multiple cell types. Additionally, Cernostics operates a high-complexity clinical reference laboratory that supports biomarker discovery, validation, and clinical trial efforts, ultimately aiming to improve patient outcomes and reduce healthcare costs. The company has established a strategic collaboration with Deciphex Limited to further its capabilities in spatial biology and AI-driven image analytics.
Carmell Therapeutics Corporation, founded in 2007 and based in Pittsburgh, Pennsylvania, specializes in the production of plasma-based biologically-active plastic medical devices designed for the treatment of bone and connective tissue injuries. The company utilizes proprietary technology developed in collaboration with Carnegie Mellon University and Allegheny General Hospital to manufacture these sterile, off-the-shelf products. Their offerings include REPAIR bone putty, which is used to fill bone defects, and a surgical scaffold that facilitates the healing of injured tendons and ligaments. These products are engineered to promote tissue healing by leveraging the body’s own growth and regenerative factors, ensuring favorable mechanical properties that align with the repaired tissue. Carmell Therapeutics primarily targets the sports medicine market, aiming to enhance clinical outcomes for patients with connective tissue injuries.
Celsense, Inc. is a biotechnology company based in Pittsburgh, Pennsylvania, specializing in the development of innovative magnetic resonance imaging (MRI) agents designed to non-invasively visualize and quantify biological processes at the cellular level. The company's primary offerings include Cell Sense, a MRI cell tracer for monitoring transplanted cells; Gene Sense, a DNA-encoded marker that allows cells to express their own contrast agent; and V-sense, a fluorine-based MRI tracer. Additionally, Celsense provides Voxel Tracker, which facilitates rapid visualization and quantification of MRI-labeled cells. These products are instrumental in regenerative medicine and immunotherapy, allowing for the monitoring of cellular therapeutics, inflammation, cancer metastases, and immune system responses. Founded in 2005, Celsense collaborates with various pharmaceutical and biotechnology organizations to develop applications suitable for human use.
Saladax Biomedical, Inc. focuses on developing and commercializing diagnostic blood tests aimed at enhancing personalized medicine in psychiatry and oncology. Established in 2004 and based in Bethlehem, Pennsylvania, the company offers a range of products under its MyCare line, including MyCare Psychiatry for determining appropriate antipsychotic dosages, MyCare Oncology for optimizing chemotherapy exposure, and MyCare Neurology for assessing neurological drug effects. Key products include My5-FU, MyPaclitaxel, MyDocetaxel, and MyImatinib, which assist healthcare professionals in personalizing treatment for various cancers and other conditions. Saladax markets its tests globally through distributors and direct sales in selected regions, striving to provide rapid and cost-effective solutions that allow clinicians to optimize drug dosing based on individual patient needs.
Cellumen specializes in cellular systems biology solutions that enhance drug discovery and safety assessment processes for biopharmaceutical researchers. By providing advanced tools for early safety evaluation and discovery toxicology, Cellumen helps organizations improve the accuracy of predicting drug efficacy and safety, ultimately reducing failure rates and development costs. The company's innovative approach addresses the complexities of disease and safety, making it a valuable partner for leading institutions such as the Mayo Clinic, Hamamatsu Photonics K.K., the EPA, FDA, NIH, and prominent pharmaceutical companies. Through its commitment to advancing drug development, Cellumen plays a crucial role in the biopharmaceutical industry.
PeriOptimum provides workflow management solutions and consulting services for the healthcare industry. It offers real-time technology and process management solutions that allow hospitals to improve workflow in the operating room environment and also enables doctors, nurses, and managers to access patient location and clinical information. The company’s solution portfolio includes RealView, a real time workflow management system that allows users to see patient status in real-time and in multiple views; PeriOperative Improvement Evaluation, a process evaluation solution for on-site analysis and off-site data extraction and analysis; Surgical Analytics Services, a service to isolate, analyze, benchmark, and improve indicators; and Surgical Capacity Improvement Program, a process improvement program for the perioperative process. It also provides PeriOp Education Services, a program that enables hospitals to train their new recruits on critical topics and orient them on the hospital's perioperative department; PathFinder, an RFID-based tracking, workflow management, and communications system; and data analytics and workflow reengineering services.
ThermalTherapeutic Systems was founded in June, 2006 by a team of highly respected experts in the field of hyperthermic perfusion technology, medical device manufacturing, molecular diagnostics and technology commercialization.
Medrobotics Corporation is a medical robotics company based in Raynham, Massachusetts, specializing in the development and commercialization of the Flex Robotic System. This innovative platform features a steerable and shapeable robotic scope that allows surgeons to navigate complex anatomy through a single, small entry point, addressing hard-to-reach areas that traditional rigid surgical tools cannot access. The Flex Robotic System is complemented by a suite of specialized instruments, including laser holders and various monopolar tools, designed for applications such as transoral robotic surgery and transoral laser microsurgery. Established in 2005 and previously known as Cardiorobotics, Inc., Medrobotics has a strong presence in the European market, focusing on enhancing minimally invasive surgical techniques and improving patient access to advanced surgical procedures.
Cognition Therapeutics, Inc. is a clinical-stage neuroscience company based in Pittsburgh, Pennsylvania, focused on developing small molecule therapeutics aimed at addressing neurodegenerative and neuro-ophthalmic disorders. Founded in 2007, the company is notable for its drug candidate CT1812, an oral brain-penetrant molecule designed to restore cellular processes disrupted by diseases such as Alzheimer’s and dry age-related macular degeneration. Cognition Therapeutics targets the toxic proteins that contribute to cognitive decline, a key factor in various degenerative diseases of the brain. The company employs proprietary assays and medicinal chemistry to create novel, high-quality drug candidates, addressing an unmet need in the treatment of these complex conditions.
Caliber Infosolutions, Inc. is a global company based in Pittsburgh, Pennsylvania, specializing in web-based software applications tailored for regulated industries, particularly in quality management for the pharmaceutical sector. The company offers several key products, including CaliberLIMS, which automates batch, lot, and sample management to ensure compliance with both internal and external specifications. Additionally, Caliber Stability facilitates the pre-registration of stability test protocols and provides detailed statistical analyses of results, along with graphical trend representations. The Caliber Pet-LIMS system delivers customized management information system reports and various testing status reports. Furthermore, Caliber CLAPS offers a controlled label printing solution designed for regulated environments. Caliber Infosolutions also provides validation, implementation, application training, and customer support services. The company serves clients across the biotech, pharmaceutical, oil, and petrochemical industries and has established strategic alliances with notable technology firms. Caliber Infosolutions was incorporated in 2008 and has since developed a reputation for its robust software solutions.
Saladax Biomedical, Inc. focuses on developing and commercializing diagnostic blood tests aimed at enhancing personalized medicine in psychiatry and oncology. Established in 2004 and based in Bethlehem, Pennsylvania, the company offers a range of products under its MyCare line, including MyCare Psychiatry for determining appropriate antipsychotic dosages, MyCare Oncology for optimizing chemotherapy exposure, and MyCare Neurology for assessing neurological drug effects. Key products include My5-FU, MyPaclitaxel, MyDocetaxel, and MyImatinib, which assist healthcare professionals in personalizing treatment for various cancers and other conditions. Saladax markets its tests globally through distributors and direct sales in selected regions, striving to provide rapid and cost-effective solutions that allow clinicians to optimize drug dosing based on individual patient needs.
Lipella Pharmaceuticals Inc. is a clinical-stage biotechnology company based in Pittsburgh, Pennsylvania, focused on developing innovative treatments for bladder-related conditions. The company specializes in intravesical therapy, delivering localized treatments directly to the urinary bladder, and its key product candidate, LP-10 (liposomal tacrolimus), is being developed for the treatment of hemorrhagic cystitis, a painful condition often affecting cancer survivors. Additionally, Lipella is exploring therapies for interstitial cystitis, overactive bladder, and superficial bladder cancer, addressing significant unmet medical needs. The company's approach includes reformulating existing generic drugs to optimize their effectiveness for new applications. Founded in 2005, Lipella Pharmaceuticals aims to improve the quality of life for patients suffering from chronic bladder disorders.
Carmell Therapeutics Corporation, founded in 2007 and based in Pittsburgh, Pennsylvania, specializes in the production of plasma-based biologically-active plastic medical devices designed for the treatment of bone and connective tissue injuries. The company utilizes proprietary technology developed in collaboration with Carnegie Mellon University and Allegheny General Hospital to manufacture these sterile, off-the-shelf products. Their offerings include REPAIR bone putty, which is used to fill bone defects, and a surgical scaffold that facilitates the healing of injured tendons and ligaments. These products are engineered to promote tissue healing by leveraging the body’s own growth and regenerative factors, ensuring favorable mechanical properties that align with the repaired tissue. Carmell Therapeutics primarily targets the sports medicine market, aiming to enhance clinical outcomes for patients with connective tissue injuries.
ParentPlus was formed to alleviate male-factor subfertility by bringing innovative biotechnology to millions of subfertile couples for whom intra-uterine insemination (IUI) might be an appropriate therapy. This therapy, with spousal or donor sperm, is underutilized ― perhaps in part because it is not typically discussed in the popular press.
Cognition Therapeutics, Inc. is a clinical-stage neuroscience company based in Pittsburgh, Pennsylvania, focused on developing small molecule therapeutics aimed at addressing neurodegenerative and neuro-ophthalmic disorders. Founded in 2007, the company is notable for its drug candidate CT1812, an oral brain-penetrant molecule designed to restore cellular processes disrupted by diseases such as Alzheimer’s and dry age-related macular degeneration. Cognition Therapeutics targets the toxic proteins that contribute to cognitive decline, a key factor in various degenerative diseases of the brain. The company employs proprietary assays and medicinal chemistry to create novel, high-quality drug candidates, addressing an unmet need in the treatment of these complex conditions.
Crystalplex Corporation, founded in 2001 and based in Pittsburgh, Pennsylvania, specializes in the development of nanocrystals for various applications, including photoluminescence, electroluminescence, and photovoltaics. The company is known for its advanced fluorescent nanoparticle technology, particularly its Sapphire quantum dots, which offer stable crystal designs and flexible polymer matrix morphologies. These products are designed to enhance the performance of high-end consumer electronics, such as LCD TVs and displays, by improving brightness and color quality. Additionally, Crystalplex serves the biomedical research, molecular diagnostic, and pathology markets, providing quicker test results from smaller samples while lowering labor costs and instrumentation expenses. Their proprietary technology meets stringent performance standards while being environmentally responsible, positioning Crystalplex as a leader in the cost-effective manufacturing of robust quantum dots for illumination and solar energy applications.
Applied Isotope Technologies, Inc. specializes in providing measurement solutions for various sectors, including industrial, medical, and academic fields. The company develops and manufactures advanced analytical tools such as direct isotope dilution mass spectrometry (D-IDMS) and direct speciated isotope dilution mass spectrometry (D-SIDMS), which are designed for accurate elemental and molecular analyses. Its product offerings encompass isotopic spikes, reagent kits, and analytical standards specifically tailored for environmental testing, food safety, and biomarker detection. Additionally, Applied Isotope Technologies offers quality assurance certification, training, and technical support services to help laboratories implement precision measurement techniques. Founded in 2003 and based in Pittsburgh, Pennsylvania, the company plays a critical role in environmental toxin detection and other complex analytical challenges.
InteloMed, Inc. manufactures a medical device, which measures patients' cardiovascular stability. It offers CVInsight Patient Monitoring & Informatics System, which captures a patient’s pulse waveform and processes this signal through proprietary algorithms and is used in hospitals, medical facilities, ambulatory, sub-acute, and sleep studies in the areas of hemodialysis, heart failure, and perio-operative. InteloMed, Inc. was founded in 2005 and is based in Warrendale, Pennsylvania.
ChemDAQ, Inc. manufactures gas detection systems for protection of personnel exposed to toxic sterilant gases. The company offers ChemDAQ sterilant gas monitoring system; and ChemDAQ data acquisition module, which provides the means of monitoring, displaying, and documenting the sterilant gas levels. It serves hospitals and various organizations.
ChemDAQ, Inc. was founded in 1996 and is based in Pittsburgh, Pennsylvania.
Celsense, Inc. is a biotechnology company based in Pittsburgh, Pennsylvania, specializing in the development of innovative magnetic resonance imaging (MRI) agents designed to non-invasively visualize and quantify biological processes at the cellular level. The company's primary offerings include Cell Sense, a MRI cell tracer for monitoring transplanted cells; Gene Sense, a DNA-encoded marker that allows cells to express their own contrast agent; and V-sense, a fluorine-based MRI tracer. Additionally, Celsense provides Voxel Tracker, which facilitates rapid visualization and quantification of MRI-labeled cells. These products are instrumental in regenerative medicine and immunotherapy, allowing for the monitoring of cellular therapeutics, inflammation, cancer metastases, and immune system responses. Founded in 2005, Celsense collaborates with various pharmaceutical and biotechnology organizations to develop applications suitable for human use.
StageMark develops and markets inflammatory diseases identification and monitoring solutions. The company's product, CB-CAPs, enables user to analyze complement products bound to various blood cell types such as erythrocytes, platelets, reticulocytes, and lymphocytes. StageMark, Inc. was founded in 2004 and is headquartered in Pittsburgh, Pennsylvania.
STARR Life Sciences Corp. specializes in the development and manufacture of research equipment for small animals, catering to life science laboratories globally. The company's product lineup includes the MouseOX Plus, a pulse oximeter that measures critical physiological parameters such as heart rate, arterial oxygen saturation, breath rate, and temperature in both anesthetized and conscious mice and rats. Additionally, STARR offers the E-Mitter Telemetry System, which enables continuous monitoring of small animals' temperature, motor activity, and heart rate, along with various related components like telemetry implants and data analysis software. Their product range also encompasses running wheels, activity cage systems, and infrared motion sensors specifically designed for rats and mice. STARR Life Sciences serves a diverse clientele, including researchers and veterinarians from universities, pharmaceutical companies, and contract research organizations. Founded in 2004, the company is headquartered in Oakmont, Pennsylvania.
Lipella Pharmaceuticals Inc. is a clinical-stage biotechnology company based in Pittsburgh, Pennsylvania, focused on developing innovative treatments for bladder-related conditions. The company specializes in intravesical therapy, delivering localized treatments directly to the urinary bladder, and its key product candidate, LP-10 (liposomal tacrolimus), is being developed for the treatment of hemorrhagic cystitis, a painful condition often affecting cancer survivors. Additionally, Lipella is exploring therapies for interstitial cystitis, overactive bladder, and superficial bladder cancer, addressing significant unmet medical needs. The company's approach includes reformulating existing generic drugs to optimize their effectiveness for new applications. Founded in 2005, Lipella Pharmaceuticals aims to improve the quality of life for patients suffering from chronic bladder disorders.
Applied Computational Technologies is a software development company that specializes in applications for the life sciences, particularly in radiation treatment planning for cancer therapy. With a significant number of cancer diagnoses in the United States, a large portion of patients undergo radiation treatment, highlighting the importance of effective planning tools. The company's flagship product, ProACTive, serves as a dose calculation engine that facilitates adaptive radiotherapy, enhancing the precision and effectiveness of cancer treatment. Through its innovative software solutions, Applied Computational Technologies aims to improve patient outcomes in the challenging field of oncology.
RedPath Integrated Pathology, LLC operates as a reference laboratory and provides support services for oncology cases. It offers PathFinderTG, a testing platform for resolving diagnoses from the original pathology specimen. The company serves pathologists, clinicians, and patients. RedPath Integrated Pathology, LLC was founded in 2004 and is headquartered in Pittsburgh, Pennsylvania.
Immunetrics, Inc. develops biological models and novel tools for mechanistic modeling needs. It offers Aegis, a software platform for the model development to model developers; disease specific models; and component model libraries. The company’s modeling software includes a set of tools that make the development of models, virtual populations, and experiments, as well as the analysis of human diseases and syndromes. It also provides mechanistic and statistical modeling, and data analysis consulting services. The company was incorporated in 2003 and is based in Pittsburgh, Pennsylvania.
StageMark develops and markets inflammatory diseases identification and monitoring solutions. The company's product, CB-CAPs, enables user to analyze complement products bound to various blood cell types such as erythrocytes, platelets, reticulocytes, and lymphocytes. StageMark, Inc. was founded in 2004 and is headquartered in Pittsburgh, Pennsylvania.
Applied Isotope Technologies, Inc. specializes in providing measurement solutions for various sectors, including industrial, medical, and academic fields. The company develops and manufactures advanced analytical tools such as direct isotope dilution mass spectrometry (D-IDMS) and direct speciated isotope dilution mass spectrometry (D-SIDMS), which are designed for accurate elemental and molecular analyses. Its product offerings encompass isotopic spikes, reagent kits, and analytical standards specifically tailored for environmental testing, food safety, and biomarker detection. Additionally, Applied Isotope Technologies offers quality assurance certification, training, and technical support services to help laboratories implement precision measurement techniques. Founded in 2003 and based in Pittsburgh, Pennsylvania, the company plays a critical role in environmental toxin detection and other complex analytical challenges.
Proteopure offers protein isolation solutions for proteomic results. The company provides a universal method for isolating proteins. Its sample preparation kit uses a protein capture technology, and can specifically separate out proteins from various contaminants, including salts, nucleic acids, and detergents. Proteopure is headquartered in Pittsburgh, Pennsylvania.
Diamyd Medical AB is a Swedish biotechnology company focused on developing therapies for autoimmune diabetes. The company is advancing its lead product, Diamyd, an antigen-specific immunomodulating vaccine designed for the treatment of type 1 diabetes and latent autoimmune diabetes, which is currently in Phase IIb clinical development. Additionally, Diamyd Medical is working on Remygen, an oral regenerative and immunomodulatory drug candidate aimed at treating autoimmune and type 2 diabetes, now in Phase I/II clinical trials. The company also leverages its GABA technology, which is integral to its proprietary drug product development. Founded in 1984 and located in Stockholm, Sweden, Diamyd Medical was previously known as Diamyd Therapeutics AB until its name change in April 2013.
Blue Belt Technologies is a medical device company that focuses on technology and capabilities of surgical instrumentation. They proprietary technology can improve minimally invasive techniques in orthopedics, providing physicians with consistency and accuracy through a myriad of intelligent hand-held tools. It also enables the development of more advanced solutions to patients’ problems.
Blue Belt Technologies was acquired by Smith & Nephew on January 5m 2016. The company was founded in 2003 and is headquartered in Pennsylvania, USA.
medSage Technologies provides software and services which enable providers in the rapidly growing home medical equipment industry.