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Safeguard Scientifics

Safeguard Scientifics, Inc. no longer investing. It is a private equity and venture capital firm specializing in expansion financings, growth capital, management buyouts, recapitalizations, industry consolidations, corporate spinouts, growth stage, and early stage financings. It initially invests in a Series A-C round and opportunistically in a seed round. The firm prefers to make investments in companies engaged in the technology, financial services, and healthcare sector. Within the technology sector, it invests in software as a service, adtech / digital media, Internet of Everything, enhanced security, predictive analytics, machine learning, artificial intelligence, enterprise software, technology enabled services, internet/new media, financial technology, cloud, mobile, social, big data, in memory, and selected business services with capital requirements of up to $25 million. Within healthcare sector, the firm invests in molecular and point-of-care diagnostics, medical devices, regenerative medicine, medical technology, digital health, healthcare technology, specialty pharmaceuticals, and selected healthcare services. It invests throughout the United States with a focus on Mid-Atlantic region, and Southeastern Canada. The firm primarily invests between $5 million and $25 million in growth equity financing and between $5 million and $10 million in early-stage financing. It typically invests in the capital structures including owner financed and bootstrapped companies, corporate division or business unit, and venture capital-backed seeking a growth partner. The firm prefers to be the largest shareholder in its portfolio companies, with ownership in the range of 20 percent to 50 percent. However, it may occasionally take a majority or smaller stake in its portfolio companies. It prefers to invest in companies having proprietary technology and intellectual property. The firm prefers to take a Board seat in its portfolio companies. The company was founded in 1953 as Lancaster Corporation and changed its name to Safeguard Scientifics, Inc. in 1981. Safeguard Scientifics, Inc. is based in Radnor, Pennsylvania with an additional office in Weston, Massachusetts.
CB

Caleb Bank

Senior Venture Capital Associate

Steven Grenfell

Senior Advisor

MH

Mark Herndon

SVP and CFO

Gary Kurtzman

Senior Advisor

Jeffrey Francis O'Donnell

Former Member of Life Sciences Advisory Board

RJ

Robert J. Rosenthal

Chairman of the Board

EC

Eric C. Salzman

CEO

HC

Heinz C. Schimmelbusch

Former Director

John E. Shave

SVP, Investor Relations and Corporate Communications

Brian Sisko

President and CEO

MW

Macy W. Summers

Former Member of Advisory Board

Seth Zuckerman

Senior Associate of Healthcare

130 past transactions

TestU

Series B in 2000
TestU an online, standardized test preparation company.

FOB.com

Venture Round in 2000
The Flying Other Brothers were an American rock band active from 1997–2006 in San Francisco. The band played original tunes and covers. The band started at an Electronic Frontier Foundation (EFF) benefit at The Fillmore Auditorium in 1997. At this time the band included Roger McNamee, a venture capitalist; Giles McNamee, investment banker, board member of EFF and Roger's brother; guitarist Bert Keely of Microsoft; Bill Bennett, a marketing and communications strategist; and Tony Bove (rechristened "TBone"), author of books about computers and the Internet. The band had its roots in acoustic performances Roger and Giles McNamee gave as the Other Brothers in lounges around New England during the early 1980s.

Trice Medical

Series C in 2017
Trice Medical is founded to fundamentally improve orthopedic diagnostics for the patient, physician, and payor by providing instant, eyes-on, answers. Trice has pioneered fully integrated camera-enabled technologies that provide a clinical solution that is optimized for the physicians office. Our mission is to provide more immediate and definitive patient care, eliminating the false reads associated with current indirect modalities and significantly reduce the overall cost to the healthcare system.

Ventaira Pharmaceuticals

Series C in 2005
Ventaira Pharmaceuticals is an emerging specialty pharmaceutical company focused on the development of new inhalation products by utilizing its novel proprietary electrohydrodynamic (EHD) aerosolization and formulation technologies.

iGrandparents.com

Series A in 2000
IGrandparents is a blog that focuses on enriching the grandparent/grandchild relationship.

GoCo-op

Venture Round in 2000
GoCo-op are is a provider of Web-based procurement systems for the hospitality industry.

Gazelle Systems

Series B in 2000
Gazelle Systems is defining the value of technology in the hospitality industry by bringing valuable information about customers to the front of the house and at the point of sale. The Gazelle team brings decades of hands-on experience to its mission and is skilled in all facets of the restaurant business - from operations and IT, to marketing and management.

Moxe Health

Venture Round in 2021
Moxe Health streamlines the bi-directional exchange of clinical data between health plans and provider systems. The company provide solutions for risk adjustment, HEDIS and Star ratings, claims denial management, HCC reconciliation, patient summary, ADT notifications, and care gap management. Plans seamlessly send back data and insights while never straying from clinicians’ EHR workflows. Moxe’s clinical data clearinghouse allows health plans to easily receive information from health systems. Health plans can then seamlessly send back data and insights. With automated solutions for risk adjustment, quality, and care management programs, Moxe facilitates access to the information essential to your success in the market shift to value-based care. Moxe’s neutrality in providing data connectivity lets you realize the full potential of your existing investments in population health, quality, and analytics solutions.

Noble.MD

Seed Round in 2016
Noble.MD develops Theo, a digital healthcare advisory platform that helps patients to identify health and behavioral risks, and activate patients to manage those risks through programs and interventions. The company’s platform captures patient data required for value-based reimbursement at the time-of-care; and aligns provider and payer interests to accelerate risk identification, coding, and management. Noble.MD was founded in 2012 and is based in Bryn Mawr, Pennsylvania.

Tengion

Series C in 2008
Tengion, a clinical-stage biotechnology company, is a leader in developing neo-organs and neo-tissues, currently derived from a patient's own (autologous) cells. The Company has completed two Phase 2 human clinical trial in the United States with its Tengion Neo-Bladder Augment for children with neurogenic bladder due to spina bifida and in adults with neurogenic bladder due to spinal cord injury. A successful academic human clinical experience with a urinary Neo-Bladder Augment was reported in The Lancet in April 2006 by investigators from the Children's Hospital Boston. Tengion has an effective investigational new drug application (IND) for its Neo-Urinary Conduit and expects to begin a Phase 1 clinical trial in the first half of 2010 in bladder cancer patients requiring bladder removal.

Pneuron

Series B in 2013
Pneuron overcomes the time, cost, and complexity challenges associated with traditional enterprise development, deployment and integration approaches. Using Pneuron’s Distributed Platform, organizations can leverage existing systems and infrastructure to connect data, applications, processes, and analytics without the need of intermediary databases, associated data integration costs or system replacement. In a single non-invasive “fabric” Pneuron allows the enterprise to manage the entire business solution lifecycle from a single screen – including development, deployment, integration, resiliency, availability and performance - freeing the enterprise to focus on realizing business value. The result is unprecedented productivity, engagement of business expertise, and reduced cost of success, inspiring new waves of innovation.

Good Start Genetics

Series B in 2012
Good Start Genetics, Inc., a molecular diagnostics company, provides genetic screening of inherited diseases. It offers EmbryVu, a preimplantation genetic screening test to improve in vitro fertilization by identifying embryos for the implantation and pregnancy. The company was founded in 2007 and is based in Cambridge, Massachusetts. As of August 4, 2017, Good Start Genetics, Inc. operates as a subsidiary of Invitae Corporation.

Garnet Biotherapeutics

Series A in 2009
Garnet BioTherapeutics is a clinical stage, venture-backed cell therapy company focused on dermal-based regenerative therapy.

Buystream

Private Equity Round in 2000
Buystream is focused on domain development and related technology solutions. It is partnered with Contrib, GlobalVentures, iFund, and iChallenge. Butstream was acquired by Watchfire in January 2004. Buystream is based in Ottawa, Ontario.

Garage Technology Ventures

Venture Round in 2000
GARAGE TECHNOLOGY VENTURES is a seed-stage and early-stage venture capital fund. They invest in entrepreneurial teams seeking to transform big ideas into game-changing companies. They invest in unproven teams attacking unproven markets with unproven solutions. They not interested in teams creating the nth solution to the same old problem nor companies trying to improve things by only 10 or 20 percent.

RedSiren

Series B in 2003
RedSiren's integrated security process includes the most critical and often-neglected component of an effective security program: security awareness and training for all employees who have access to information technology resources. End users often are a corporate information security program's weakest link. Through their unique Information Security UniversityTM (InfoSecUTM), RedSiren offers a comprehensive, affordable, Web-based security awareness curriculum to organizations and individuals who want to expand their understanding of information security principles and best practice. The courses are self-paced and highly interactive. InfoSecU provides on-demand training to individual users from a variety of platforms and locations. Evaluation, tracking and reporting tools enable individuals and managers to track progress and assess mastery. Enterprise licensing of the InfoSecU courseware is available to allow you to host the InfoSecU library on internal Learning Management Systems servers. Individual courses and tracks can be licensed to meet your specific needs.

Advanced BioHealing

Series C in 2007
Advanced BioHealing is an industry leader in the science of regenerative medicine. The Company is focused on the commercialization of cell-based and tissue-engineered products. It currently markets the FDA-approved product Dermagraft®, for diabetic foot ulcers. Additionally, the Company's development pipeline includes a next-generation bioengineered tissue product which is in clinical trials. ABH is a privately held company with research & development offices in New York, NY and manufacturing operations in La Jolla, CA.

Full Measure Education

Series B in 2016
Full Measure Education is a Student Lifecycle and Retention Management company developing a student-facing mobile/social/web technology and human-powered retention services that keep students from dropping out of college. Full Measure Education’s cutting edge approach and technology design is the result of lessons learned by its senior management through 10,000,000 plus student help desk interactions at 850 plus colleges and universities. As a result, Full Measure Education has more post-secondary experience with which to deliver extraordinary outcomes in every major benchmark, including retention, enrollment growth, operational efficiencies, and financial aid utilization.

GoCo-op

Venture Round in 1999
GoCo-op are is a provider of Web-based procurement systems for the hospitality industry.

Transactis

Series D in 2014
Transactis transforms traditional paper billing and payment processing by enabling businesses of all sizes to replace paper bills, statements, invoices, payments and documents with more efficient digital alternatives. Transactis goes to market exclusively with resellers—financial institutions, technology companies, printers and business process outsourcers—to provide their customers with secure, configurable, white-label, industry-leading SaaS solutions. More than a technology provider to resellers, Transactis is a full-service business partner, delivering a broad and deep suite of sales, marketing, technical and operational support, empowering resellers to more successfully serve their clients. Transactis meets the strictest regulatory and compliance requirements including HIPAA, SSAE 16, PCI Level 1, and SOC 2. Transactis’ investors include ff Venture Capital, MacAndrews & Forbes, Metamorphic Ventures, Safeguard Scientifics, StarVest Partners, Capital One, Fifth Third Bank, PNC, TD Bank and Wells Fargo.

Bridgevine

Series B in 2007
Updater’s Home Services Division provides innovative technology that simplifies the purchase of home subscription products across telecommunications, cable, satellite, home security, home improvement, and home energy.

Clutch Holdings, LLC

Series B in 2015
Clutch serves as a customer marketing platform for business-to-consumer brands. It provides traditional marketing CRM, loyalty, gift card, mobile, email, and direct mail solutions. The company was created to help businesses succeed in an evolving marketing landscape. Since 2012, they have continued to grow their platform into an innovative, data-centric marketing solution with one focus that empowering brands with the best technology so that they can identify, understand and motivate their customers.

Wine Access

Venture Round in 2000
Drink only the most extraordinary wines, hand selected by a Master of wine and Master sommelier. Each wine passes rigorous screening to ensure it meets world class standards, and the quality and provenance of the wine is controlled and guaranteed from the winery to your door.

Hoopla Software, Inc.

Series A in 2011
Hoopla Software, Inc. develops and offers visual communication platform that connects, engages, and motivates employees in an organization. Its platform provides sales performance optimization platform as a service which leverages data, game mechanics, and communication tools to cultivate a high performance culture and drive results for sales employees. The company's products include Hoopla TV and Hoopla Mobile. Hoopla Software, Inc. was incorporated in 2008 and is based in San Jose, California.

Bridgevine

Venture Round in 2009
Updater’s Home Services Division provides innovative technology that simplifies the purchase of home subscription products across telecommunications, cable, satellite, home security, home improvement, and home energy.

DriveFactor

Series A in 2011
DriveFactor is a consolidated contractors company that offers a range of insurance telematics technology solutions. The DriveFactor platform is built on a dynamic, scalable architecture, accepting data from any input method and enabling easy sharing with business partners. The team has built its technology and apps for insurance, and applies its expertise to help clients customize telematics solutions to meet their short- and long-term needs. It was founded in 2010 and is based in Glen Allen, Virginia, USA.

meQuilibrium

Series B in 2015
meQuilibrium offers individuals and employees with online stress management solutions and measurements. It is the only clinically validated resilience platform leveraging behavioral psychology, neuroscience, and analytics to deliver transformative insights that change lives and businesses. meQuilibrium was founded in 2010 and is headquartered in Boston, Massachusetts.

Internet Publishing Group

Venture Round in 2000
A provider of specialized market news and analysis for B2B Web sites.

Clutch Holdings, LLC

Venture Round in 2013
Clutch serves as a customer marketing platform for business-to-consumer brands. It provides traditional marketing CRM, loyalty, gift card, mobile, email, and direct mail solutions. The company was created to help businesses succeed in an evolving marketing landscape. Since 2012, they have continued to grow their platform into an innovative, data-centric marketing solution with one focus that empowering brands with the best technology so that they can identify, understand and motivate their customers.

InfoBionic, Inc.

Series B in 2016
InfoBionic transforms the efficiency and the economics of ambulatory remote patient monitoring processes and cardiac diagnostic services by optimizing clinical and real-world utility for the users that need it most – physicians and their patients. It has developed the MoMe System, a remote patient monitoring platform initially focused on cardiac arrhythmia detection, to improve clinical efficiency and patient care with any time, anywhere access to patient data. The company was founded in 2011 and is headquartered in Waltham, Massachusetts.

Portico Systems

Series A in 2006
Portico's technology enables healthcare organizations to design, build, service and provide value-based reimbursement to their complex provider networks. It also provides the ability to align and automate key network management activities including, provider enrollment, credentialing, contracting and pricing.

Magic Bean Stalk

Series A in 2000
MagicBeanStalk helps the startup community find information, conduct transactions, and communicate more easily, bringing greater efficiency, reduced costs and faster growth to startups everywhere. In just a few short months, you'll be able to sift through profiles of the fastest growing Internet and high-tech startups across the globe, connect with service providers, participate in online discussions with industry leaders and share valuable information about your startup experience.

QuanticMind Inc.

Series A in 2015
QuanticMind Inc. provides a software-as-a-service predictive advertising management software for paid search, social, display, and mobile. The company offers QuanticMind Shopping, a solution that unifies cross-channel and third-party data, as well as extracts relevant data and insights to inform and perform advertising decisions. It also offers services that include data quality; resolving issues on-site, and phone and Web support; and training and certification. QuanticMind Inc. was formerly known as InsideVault Inc. The company was founded in 2011 and is based in San Carlos, California.

Syapse

Series D in 2017
Syapse works with leading health systems, life sciences companies, and regulators to accelerate real-world evidence to improve the outcomes of cancer patients. By bringing these organizations together into the Syapse Learning Health Network, Syapse has built one of the world’s largest networks dedicated to improving outcomes in cancer care through improved precision medicine. Syapse and its partners are working towards a future in which all cancer patients have access to the quality of care they need. The company was founded in 2008 and is headquartered in San Francisco, California.

Prognos

Series B in 2013
Prognos is a healthcare AI company focused on eradicating disease by driving decisions earlier in healthcare in collaboration with payers, Life Sciences and diagnostics companies. The Prognos Registry is the largest source of clinical diagnostics information in over 30 disease areas, with over 5B medical records for 100M patients. Prognos has 500 extensive proprietary and learning clinical algorithms to enable earlier patient identification for enhanced treatment decision-making, risk management and quality improvement.
Cognitive Operational Systems, LLC develops inventory management solutions for the retail sector by robotics using computer vision and artificial intelligence. The company’ technology enables robots to navigate retail store floors, managing inventory, ensuring planogram, and promotional compliance, as well as provides indoor localization and turn-by-turn navigation in environments, such as indoors. Its technology also maps stores, including layout and architecture. The company was founded in 2012 and is based in Philadelphia, Pennsylvania.

meQuilibrium

Series C in 2018
meQuilibrium offers individuals and employees with online stress management solutions and measurements. It is the only clinically validated resilience platform leveraging behavioral psychology, neuroscience, and analytics to deliver transformative insights that change lives and businesses. meQuilibrium was founded in 2010 and is headquartered in Boston, Massachusetts.

Mi8 Corporation

Venture Round in 2000
Mi8 is a leading application services provider, enabling organizations to enhance productivity, reduce costs. The New York-based application service provider takes pricey enterprise software and turns it into services that companies can rent and use in a subscription model.

Sotera Wireless

Venture Round in 2014
Sotera Wireless, Inc. is a medical device company dedicated to the development, marketing and sale of a new generation of comprehensive vital signs monitoring. Sotera’s mission is to improve patient safety by empowering clinicians to detect early signs of deterioration in virtually any care setting and enable early intervention and rapid response, all without limiting the patient’s freedom of movement.
Advantedge Healthcare Solutions, Inc. designs and develops software for the healthcare industry. The company offers medical billing software. Additionally, it provides radiology, cardiology, anesthesia and pain management, neonatology, internal medicine, and multi specialty medical billing services. The company also offers revenue cycle management services to physicians and medical billing companies. It caters to hospitals and office based specialty physician practices. Advantedge Healthcare Solutions, Inc. was founded in 1999 and is based in Warren, New Jersey.

Trice Medical

Series B in 2015
Trice Medical is founded to fundamentally improve orthopedic diagnostics for the patient, physician, and payor by providing instant, eyes-on, answers. Trice has pioneered fully integrated camera-enabled technologies that provide a clinical solution that is optimized for the physicians office. Our mission is to provide more immediate and definitive patient care, eliminating the false reads associated with current indirect modalities and significantly reduce the overall cost to the healthcare system.

MedCrypt

Seed Round in 2016
MedCrypt is a medical device company that provides data security as a service to medical device OEMs. From medical imaging device to implantable devices like pacemakers, MedCrypt ensures that devices act only on instructions from trusted sources. It brings security features to medical devices, from pacemakers to surgical robots, in a few lines of code. The company enables engineers to implement these security features properly as quickly as possible, allowing them to get back to designing life-changing clinical features. MedCrypt was founded in 2016 and is headquartered in Encinitas, California, United States.

NovaSom, Inc.

Series D in 2011
NovaSom, Inc. is a privately held diagnostic-service provider for home testing and evaluation of sleep-disordered breathing, which includes the diagnosis of obstructive sleep apnea (OSA). Based in Glen Burnie, Maryland, the company was incorporated in 1992. NovaSom is a Medicare-approved Independent Diagnostic Testing Facility (IDTF) and is fully accredited as both an Ambulatory Care Sleep Diagnostic Center and as a Telehealth provider by The Joint Commission. The home testing system manufactured and distributed by NovaSom has FDA clearance for the diagnostic evaluation of OSA in adults. NovaSom has integrated their home sleep testing system into a cloud based, collaborative patient management platform for physicians and payers.

Swaptree Inc.

Series D in 2010
Swaptree is a website that allows users to trade books, CDs, DVDs and video games with other users for freeSwaptree.com provides a platform for trading among its customers. The Company offers a site where the user can freely swap new and used DVDs, CDs, video games, and books with other members. Swaptree.com conducts services in the United States.

Moxe Health

Series B in 2022
Moxe Health streamlines the bi-directional exchange of clinical data between health plans and provider systems. The company provide solutions for risk adjustment, HEDIS and Star ratings, claims denial management, HCC reconciliation, patient summary, ADT notifications, and care gap management. Plans seamlessly send back data and insights while never straying from clinicians’ EHR workflows. Moxe’s clinical data clearinghouse allows health plans to easily receive information from health systems. Health plans can then seamlessly send back data and insights. With automated solutions for risk adjustment, quality, and care management programs, Moxe facilitates access to the information essential to your success in the market shift to value-based care. Moxe’s neutrality in providing data connectivity lets you realize the full potential of your existing investments in population health, quality, and analytics solutions.

NexTone Communications

Series C in 2004
NexTone Communications, headquartered in Rockville, Md., is focused on delivering Internet-based solutions for voice and data convergence to service providers. NexTone is in touch with the needs of the communications industry and is building products and solutions that facilitate the delivery of next generation applications. NexTone Communication's solutions represent what's next in convergence.

Prognos

Series A in 2011
Prognos is a healthcare AI company focused on eradicating disease by driving decisions earlier in healthcare in collaboration with payers, Life Sciences and diagnostics companies. The Prognos Registry is the largest source of clinical diagnostics information in over 30 disease areas, with over 5B medical records for 100M patients. Prognos has 500 extensive proprietary and learning clinical algorithms to enable earlier patient identification for enhanced treatment decision-making, risk management and quality improvement.

CloudMine

Series A in 2015
Rethink how you develop mobile applications. Significantly reduce your time to deployment, total cost, and overall ease of mind when it comes to developing mobile applications, integrating disparate datasets and maintaining IT infrastructures. CloudMine is a Managed Mobility solution that: 1) Eliminates the need for ongoing maintenance and management of mobile applications. 2) Accelerates app development by 70% through mobile-optimized infrastructure and a suite of prefabricated web services. 3) Standardizes your mobility platform to provide IT-approved common tooling across all business units.

eonDigital

Venture Round in 2000
eonDigital provides a web-based application which presents an intuitive environment for workgroup collaboration, project control, content management, digital rights protection and customized, on-demand publishing.

Good Start Genetics

Series A in 2010
Good Start Genetics, Inc., a molecular diagnostics company, provides genetic screening of inherited diseases. It offers EmbryVu, a preimplantation genetic screening test to improve in vitro fertilization by identifying embryos for the implantation and pregnancy. The company was founded in 2007 and is based in Cambridge, Massachusetts. As of August 4, 2017, Good Start Genetics, Inc. operates as a subsidiary of Invitae Corporation.

Avid Radiopharmaceuticals

Series D in 2009
Avid develops molecular imaging agents to aid medical management of chronic human diseases. They are located in Philadelphia, PA. Their mission is to develop new molecular imaging agents capable of changing the medical management of significant, chronic human diseases by identifying the first stages of pathological change, potentially assisting in earlier diagnosis, and better management and development of new therapies.

WebTelecom

Series A in 2000
WebTelecom, an application service provider offering Web-based contact center services.

Velano Vascular

Series A in 2016
Velano Vascular's technologies transform care by reducing the stress and anxiety related to blood draws during hospitalization. The company's needle-free device reduces pain and discomfort for patients, and enhances safety and efficiency for providers. Founded by a patient and a physician, Velano Vascular is backed by First Round Capital, Kapor Capital and White Owl Capital. The company’s collaborators include leading U.S. hospital systems and organizations innovating in patient-centered care.

Authentium

Series A in 2006
Authentium, Inc. provides security software and services. It offers SafeCentral, a secure Internet that is designed to enable protected e-commerce; and Command Antivirus, an antivirus product. The company's technologies are used by software providers. Authentium, Inc. was founded in 1999 and is based in Palm Beach Gardens, Florida.

Techonline

Series B in 2000
TechOnLine has created a worldwide online community of more than 335,000 electronics engineering professionals by providing in-depth information, product services and training materials to the electronics technology industry. TechOnLine's business comprises three separate units: Marketing & Promotional Services (encompassing online webcasting, sponsorship programs and email marketing), E-Training and VirtuaLab, an online electronics evaluation tool.

Crescendo Bioscience

Series D in 2013
Crescendo Bioscience, Inc. develops quantitative and objective diagnostic tools to provide rheumatologists with clinical insights to manage patients with autoimmune and inflammatory diseases. It provides diagnostic, prognostic, staging, therapy selection, and monitoring facilities to physicians. Crescendo Bioscience, Inc. was formerly known as Riley Genomics, Inc. The company was founded in 2002 and is based in South San Francisco, California.

Quantia

Series B in 2013
QuantiaMD is the largest online community and collaboration platform for physicians. 160,000 physicians share real-life experiences from clinical practice, nationwide, in minutes rapidly, and in large numbers, allowing them to adapt to changes faster and apply the latest medical thinking to their practices. Through QuantiaMD’s platform, healthcare organizations can quickly engage and align physicians to achieve important objectives and goals that lead to a better quality of care. Built from the ground up for how physicians work today, QuantiaMD is easy-to-use, secure, and fully mobile.

QuanticMind Inc.

Series B in 2017
QuanticMind Inc. provides a software-as-a-service predictive advertising management software for paid search, social, display, and mobile. The company offers QuanticMind Shopping, a solution that unifies cross-channel and third-party data, as well as extracts relevant data and insights to inform and perform advertising decisions. It also offers services that include data quality; resolving issues on-site, and phone and Web support; and training and certification. QuanticMind Inc. was formerly known as InsideVault Inc. The company was founded in 2011 and is based in San Carlos, California.

ThingWorx

Series B in 2011
ThingWorx radically transforms application development for the the connected world, allowing companies to achieve a step change in operational innovation and resource efficiency.

Hoopla Software, Inc.

Series B in 2014
Hoopla Software, Inc. develops and offers visual communication platform that connects, engages, and motivates employees in an organization. Its platform provides sales performance optimization platform as a service which leverages data, game mechanics, and communication tools to cultivate a high performance culture and drive results for sales employees. The company's products include Hoopla TV and Hoopla Mobile. Hoopla Software, Inc. was incorporated in 2008 and is based in San Jose, California.

Transactis

Series E in 2016
Transactis transforms traditional paper billing and payment processing by enabling businesses of all sizes to replace paper bills, statements, invoices, payments and documents with more efficient digital alternatives. Transactis goes to market exclusively with resellers—financial institutions, technology companies, printers and business process outsourcers—to provide their customers with secure, configurable, white-label, industry-leading SaaS solutions. More than a technology provider to resellers, Transactis is a full-service business partner, delivering a broad and deep suite of sales, marketing, technical and operational support, empowering resellers to more successfully serve their clients. Transactis meets the strictest regulatory and compliance requirements including HIPAA, SSAE 16, PCI Level 1, and SOC 2. Transactis’ investors include ff Venture Capital, MacAndrews & Forbes, Metamorphic Ventures, Safeguard Scientifics, StarVest Partners, Capital One, Fifth Third Bank, PNC, TD Bank and Wells Fargo.

Wireless Online Inc.

Venture Round in 2000
Wireless OnLine is a privately held company with headquarters in Los Altos, CA, R&D facilities in Tel Aviv, Israel and Sales and Service in Dallas, Texas. The company develops and commercializes breakthrough wireless telecommunications technologies to increase coverage, expand capacity and improve quality in wireless data networks. Its first product, the WOL-2000R provides the personal communications industry with smart antenna solutions based on Spatial Division Multiple Access and Motorola's ReFLEX technology.

Propeller Health

Series D in 2018
Propeller Health is a mobile platform that offers sensors, mobile apps, analytics, and services to support respiratory health management. The HIPAA compliant platform stores users’ data in a cloud computing infrastructure. The Propeller sensor and mobile application help users learn more about and better manage their asthma, COPD, and respiratory disease. The Propeller sensor attaches to users’ inhalers and wirelessly syncs with their smartphones. It tracks their triggers and symptoms and sends personalized feedback and education to their phones based on the symptoms. Users can see how often they use the medication, and set up medication reminders and alerts. Propeller community enables users to share their Propeller data with their physician and family members. Propeller Health is backed by Safeguard Scientifics, The Social+Capital Partnership, California HealthCare Foundation, and other investors.  The platform works with organizations such as Dignity Health, Wyckoff Heights Medical Center, Amerigroup Florida, and the City of Louisville. The system has been featured in The Economist, Washington Post, Fast Company, Wired, and Scientific American. Propeller Health has received TEDMED Innovation Showcase, White House Champion of Change, and Bluetooth Breakthrough Product awards. Propeller Health was launched by David Van Sickle, Greg Tracy, and Mark Gehring and its operations are based in Wisconsin, United States.

Portico Systems

Venture Round in 2008
Portico's technology enables healthcare organizations to design, build, service and provide value-based reimbursement to their complex provider networks. It also provides the ability to align and automate key network management activities including, provider enrollment, credentialing, contracting and pricing.

T-Rex Group, Inc.

Grant in 2016
Enterprise Fintech Platform: T-REX’s mission is to make complex capital markets more liquid through enhanced transparency and efficiency. In order to facilitate growth in complex asset classes, T-REX aims to continuously build effective market-relevant financial infrastructure that allows complex markets to be more robust through unprecedented transparency. T-REX is the financial and risk analytics platform for complex asset classes: increasing standardization, efficiency, and transparency. Through its enterprise SaaS platform, T-REX unlocks hundreds of billions of dollars currently seeking investment through modules that combine analysis across assets, loans, bonds, and other capital structures. Before T-REX, the value of the assets was opaque, non-standard, and manually evaluated one asset at a time. With T-REX, industry participants can now efficiently invest in, securitize, and manage portfolios of assets with complete transparency.

CloudMine

Series A in 2017
Rethink how you develop mobile applications. Significantly reduce your time to deployment, total cost, and overall ease of mind when it comes to developing mobile applications, integrating disparate datasets and maintaining IT infrastructures. CloudMine is a Managed Mobility solution that: 1) Eliminates the need for ongoing maintenance and management of mobile applications. 2) Accelerates app development by 70% through mobile-optimized infrastructure and a suite of prefabricated web services. 3) Standardizes your mobility platform to provide IT-approved common tooling across all business units.

Full Measure Education

Series B in 2015
Full Measure Education is a Student Lifecycle and Retention Management company developing a student-facing mobile/social/web technology and human-powered retention services that keep students from dropping out of college. Full Measure Education’s cutting edge approach and technology design is the result of lessons learned by its senior management through 10,000,000 plus student help desk interactions at 850 plus colleges and universities. As a result, Full Measure Education has more post-secondary experience with which to deliver extraordinary outcomes in every major benchmark, including retention, enrollment growth, operational efficiencies, and financial aid utilization.

NexTone Communications

Series B in 2000
NexTone Communications, headquartered in Rockville, Md., is focused on delivering Internet-based solutions for voice and data convergence to service providers. NexTone is in touch with the needs of the communications industry and is building products and solutions that facilitate the delivery of next generation applications. NexTone Communication's solutions represent what's next in convergence.

VitalTrax

Seed Round in 2017
VitalTrax connects patients with clinical trials with its cloud-based clinical trial network. VitalTrax offers Wing, a solution that simplifies clinical trials enrollment. Wing is a clinical trial network that provides innovative ways for people to easily seek optional treatments for themselves or people that they love and play an important role in helping develop new ways to fight diseases.

Beyond.com

Series A in 2007
Beyond.com, Inc. operates an online career network to connect job seekers and employers through career channels, and industry and regional communities. Beyond.com, it’s all about focus – and results. You identify the candidates you want to reach, and we’ll help you target them through relevant industry, local and specialty channels. Using our precise targeting abilities, we are able to deliver quality results through recruitment advertising, email marketing, mobile and social channels, and other highly effective tactics. A focused search means more qualified candidates. Get started today, with Beyond.com.

HoopsTV.com

Series B in 1999
HoopsTV.com turns your computer into a 24-hour basketball network, delivering a world of basketball.

Brickwork

Series A in 2016
Brickwork powers the new Pre-Visit Experience for customers of the world’s leading brands and retailers. Brickwork’s SaaS platform delivers a better pre-visit experience: providing their customers more accurate store information, more access to events and promotions, more personal assistance when they arrive in-store, and more confidence that products are available near them. Brickwork opens a new world of actionable data for marketers and store teams, starting with its unique measure of Digital-to-Store Conversion, to drive traffic, engagement, conversion, and basket size. It was founded in 2013 and is headquartered in New York, New York.

InfoBionic, Inc.

Venture Round in 2018
InfoBionic transforms the efficiency and the economics of ambulatory remote patient monitoring processes and cardiac diagnostic services by optimizing clinical and real-world utility for the users that need it most – physicians and their patients. It has developed the MoMe System, a remote patient monitoring platform initially focused on cardiac arrhythmia detection, to improve clinical efficiency and patient care with any time, anywhere access to patient data. The company was founded in 2011 and is headquartered in Waltham, Massachusetts.

E-Duction

Series A in 2000
E-Duction is at the forefront of the evolving payment industry – paying for goods and services via payroll deduction. The current advent of consumerism is creating demand for more complex payroll deduction products, including variable and dynamic products in which the deduction/payment amount may change each month. E-Duction's transaction processing capabilities make possible a wide range of profitable, consumer-friendly payroll deduction-based services which meet the key demands of today's large and small employers alike.

Sonobi

Series A in 2015
Sonobi is an advertising technology developer that offers better ways for publishers, media agencies and advertiser brands to drive results and achieve business goals—through user-centric technology and intelligent data—creating more effective advertising and better connections between people and brands. Since 2011, Sonobi has been helping clients and strategic partners from across digital advertising forecast new market opportunity, enhance value delivery to clients, and create more profitable businesses.

Acsis

Acquisition in 2005
Acsis, Inc. provides track and trace solutions for supply chain safety and security. The company offers process-automation platforms, pre-built processes and workflows, appliances, automated SAP integration, and serialization solutions, which automates data collection, streamlines manufacturing and distribution processes, and provides real-time access to supply chain information. Acsis is the leader in real-time track and traceability software that enables effective recall management, anti-diversion, and anti-counterfeiting measures for the CPG, Life Sciences and Chemical industries. By using Acsis ProducTrak software, organizations can track and trace products through its entire lifecycle - from the raw materials to finished goods. But true product visibility doesn't stop there. Tracking products in real-time at the item level through packaging, rework, repacking, adding to case and pallets, moving through the distribution channel, and finally to end user - such as a hospital or retail store - is what Acsis is known for. This type of visibility provides the data needed to pinpoint products for recall returns or highlights suspect areas in the distribution network where diversion or shrink is suspected. The company was founded in 1996 and is based in Marlton, New Jersey.

NuPathe, Inc.

Series B in 2008
NuPathe Inc., a specialty pharmaceutical company, focuses on the development and commercialization of branded therapeutics for neurological and psychiatric disorders. The company’s lead product is Zecuity, which is a sumatriptan iontophoretic transdermal system used for the acute treatment of migraine with or without aura in adults. Its pipeline product candidates include NP201 for the continuous symptomatic treatment of Parkinson's disease; and NP202 for the long-term treatment of schizophrenia and bipolar disorder. The company develops its products using SmartRelief, a proprietary transdermal medication delivery technology based on iontophoresis, a non-invasive method of actively transporting molecules, such as sumatriptan; and Long-Acting Delivery, a biodegradable polymer matrix, which uses medical polymers and an active drug combined to form a small implant for injection just below the skin. NuPathe Inc. was founded in 2005 and is based in Malvern, Pennsylvania. As of February 20, 2014, NuPathe, Inc. operates as a subsidiary of Teva Pharmaceutical Industries Limited.

Dabo Health

Series A in 2013
Dabo Health provides the healthcare community a free platform to view and track improvement in key performance metrics, to collaborate across hospitals and healthcare systems, and to identify and share evidence based best practices in order to save lives. In the era of Big Data, we enlighten individuals, organizations and industries and empower fundamental change at all levels. By combining human-powered insights with raw, objective data, we inform confident decisions and drive efficiencies. Ours is a system that rewards collaboration with innovative ideas that are integral to the progression of humanity. We call it “The Power of Collective Intelligence.” We channel this shared knowledge of passionate professionals to empower progress.

Apprenda

Series D in 2015
Apprenda is a developer of a cloud-based enterprise platform used to power the next generation of enterprise software development. The company creates and supports modern, enterprise-ready application platforms for both cloud-native and traditional application workloads. With more than a decade of deep, enterprise customer insights, it provides compatible solution offerings for both individuals and IT departments, removing friction from the software delivery process and transforming IT into an engine of growth. Apprenda was established in 2007 and is headquartered in Troy, New York.

Lumesis, Inc.

Series A in 2012
Lumesis, Inc. operates as a Software-as-a-Service and cloud-based financial technology company that provides regulatory and data solutions for the municipal marketplace. It offers DIVER Analytics, a solution that provides clients with access to various datasets, as well as a suite of analytical and visualization tools that address the realities of the municipal marketplace, such as stale financials, fiscal uncertainty, and infrequent ratings. The company also offers DIVER Advisor, a solution that is used to support clients’ evolving regulatory needs that address time-of-trade disclosure, supervision, and suitability; DIVER Data Services, a solution that provides clients with access to data and custom datasets formatted and delivered to the platform; and DIVER Geo Score that represents the score of the economic health of a particular geographic area to assist users in understanding the overall economic health of a selected geographic area. It serves the U.S. banks, broker/dealers, asset managers, insurance companies, hedge funds, municipal index providers, credit analysts, portfolio managers, risk managers, legal and compliance professionals, financial advisors, and private wealth managers. Lumesis, Inc. was founded in 2010 and is based in Stamford, Connecticut.

incuVest

Private Equity Round in 2000
incuVest LLC is an operating company actively engaged in creating an interrelated network of technology incuVators ("Partner incuVators"). Partner incuVators are companies dedicated to creating and developing in-house companies ("incubees") which mature into independent companies ("spin-outs"). Each spin-out is a candidate for an IPO and has the potential to be a substantial public company. incuVest's Partner incuVators are dedicated to business incubation and technology innovation. They have the Critical Mass (people, systems and resources) needed to employ a unique Innovation Methodology for creating leading edge technology companies. This proven and predictable process for company building creates a "Vision to IPO" timeframe of two to three years.

Cask Data, Inc.

Series B in 2015
Acquired by Google. Founded by developers for developers, Cask, the open source software company makes building and running big data solutions easy, provides the first unified integration platform for big data that cuts down the time to production for data applications and data lakes by 80%. Based in Palo Alto, Calif., the company is backed by leading investors including Battery Ventures, Andreessen Horowitz, and Ignition Partners.

Propeller Health

Series C in 2016
Propeller Health is a mobile platform that offers sensors, mobile apps, analytics, and services to support respiratory health management. The HIPAA compliant platform stores users’ data in a cloud computing infrastructure. The Propeller sensor and mobile application help users learn more about and better manage their asthma, COPD, and respiratory disease. The Propeller sensor attaches to users’ inhalers and wirelessly syncs with their smartphones. It tracks their triggers and symptoms and sends personalized feedback and education to their phones based on the symptoms. Users can see how often they use the medication, and set up medication reminders and alerts. Propeller community enables users to share their Propeller data with their physician and family members. Propeller Health is backed by Safeguard Scientifics, The Social+Capital Partnership, California HealthCare Foundation, and other investors.  The platform works with organizations such as Dignity Health, Wyckoff Heights Medical Center, Amerigroup Florida, and the City of Louisville. The system has been featured in The Economist, Washington Post, Fast Company, Wired, and Scientific American. Propeller Health has received TEDMED Innovation Showcase, White House Champion of Change, and Bluetooth Breakthrough Product awards. Propeller Health was launched by David Van Sickle, Greg Tracy, and Mark Gehring and its operations are based in Wisconsin, United States.

GoCo-op

Venture Round in 2000
GoCo-op are is a provider of Web-based procurement systems for the hospitality industry.

Aventura Software

Series C in 2015
Aventura intelligently orchestrates assets, people, and systems to deliver the right information at the right time based on location and credentials. It locates and re-assigns the closest online printer and uniquely manages print routing to make it easier to detect and fix printing failures. Aventura was formed in 2007 and headquartered in Denver, Colorado.
Molecular Biometrics, Inc., is applying novel metabolomic technologies to develop accurate, non-invasive methodologies for evaluating normal biologic function in health and disease, and for drug discovery and development. The company's proprietary technology is being applied in reproductive health, neurodegenerative disease (Alzheimer's disease and Parkinson's disease), maternal fetal medicine, pulmonary metabolism and edema, and lactate metabolism.

InfoBionic, Inc.

Series B in 2014
InfoBionic transforms the efficiency and the economics of ambulatory remote patient monitoring processes and cardiac diagnostic services by optimizing clinical and real-world utility for the users that need it most – physicians and their patients. It has developed the MoMe System, a remote patient monitoring platform initially focused on cardiac arrhythmia detection, to improve clinical efficiency and patient care with any time, anywhere access to patient data. The company was founded in 2011 and is headquartered in Waltham, Massachusetts.

Authentium

Series B in 2007
Authentium, Inc. provides security software and services. It offers SafeCentral, a secure Internet that is designed to enable protected e-commerce; and Command Antivirus, an antivirus product. The company's technologies are used by software providers. Authentium, Inc. was founded in 1999 and is based in Palm Beach Gardens, Florida.

iMedium

Series B in 2000
IMedium, Inc. develops an Application Service Provider (ASP) that enables the delivery of highly visual, intuitive Web interactions to business customers, future clients and trading partners.

Hoopla Software, Inc.

Series A in 2012
Hoopla Software, Inc. develops and offers visual communication platform that connects, engages, and motivates employees in an organization. Its platform provides sales performance optimization platform as a service which leverages data, game mechanics, and communication tools to cultivate a high performance culture and drive results for sales employees. The company's products include Hoopla TV and Hoopla Mobile. Hoopla Software, Inc. was incorporated in 2008 and is based in San Jose, California.

Putney, Inc.

Series C in 2011
Putney is a pharmaceutical company specializing in the development of high quality drugs for pets. They focus on developing generics for frequently used drugs where cost is a barrier to prescribing, compliance or use. They offer our prescription drugs for sale to companion animal veterinarians —veterinarians who treat pets.

Rubicor Medical

Series C in 2006
Rubicor Medical is develops and distributes technologically advanced, disposable, non-invasive, breast biopsy devices.

MediaMath

Venture Round in 2009
MediaMath, Inc. develops and delivers digital advertising media and data management technology solutions to advertisers worldwide. The company’s TerminalOne platform activates data, automates execution, and optimizes advertising interactions across addressable media. Its Omnichannel programmatic marketing platform activates predictive audience to enhance one-to-one customer conversations; accesses Omnichannel media at scale to deliver relevance of context and message; closes the loop between measurement and optimization with machine learning; and leverages people in the business. The company also provides professional services in the areas of programmatic strategy and optimization, analytics, technology support, and advertising operations; and training and certification programs focusing on digital marketing. MediaMath, Inc. was founded in 2007 and is headquartered in New York, New York with additional offices in San Francisco and Santa Monica, California; Boston, Massachusetts; Chicago, Illinois; Miami, Florida; Durham, North Carolina; London, United Kingdom; Madrid, Spain; Berlin; Singapore; Tokyo, Japan; Sao Paulo, Brazil; Sydney and Melbourne, Australia; and Bengaluru, India.

EqualFooting.com

Series B in 2000
EqualFooting.com, a B2B online marketplace that places small businesses on equal footing with large companies in the areas of purchasing.

E-Duction

Series B in 2000
E-Duction is at the forefront of the evolving payment industry – paying for goods and services via payroll deduction. The current advent of consumerism is creating demand for more complex payroll deduction products, including variable and dynamic products in which the deduction/payment amount may change each month. E-Duction's transaction processing capabilities make possible a wide range of profitable, consumer-friendly payroll deduction-based services which meet the key demands of today's large and small employers alike.

Sotera Wireless

Series D in 2013
Sotera Wireless, Inc. is a medical device company dedicated to the development, marketing and sale of a new generation of comprehensive vital signs monitoring. Sotera’s mission is to improve patient safety by empowering clinicians to detect early signs of deterioration in virtually any care setting and enable early intervention and rapid response, all without limiting the patient’s freedom of movement.

WebLinc

Series A in 2014
WebLinc is the commerce platform and services provider for the fastest growing online retailers. WebLinc’s modern, agile technologies and strategic expertise empower companies running global, omnichannel commerce operations, and enable retailers to consistently out-pace the competition. WebLinc supports a number of highly successful retail and B2B clients including URBN's Free People brand, US Polo Association, The Mint Julep Boutique, Jordache, and Sanrio.

Syapse

Series F in 2020
Syapse works with leading health systems, life sciences companies, and regulators to accelerate real-world evidence to improve the outcomes of cancer patients. By bringing these organizations together into the Syapse Learning Health Network, Syapse has built one of the world’s largest networks dedicated to improving outcomes in cancer care through improved precision medicine. Syapse and its partners are working towards a future in which all cancer patients have access to the quality of care they need. The company was founded in 2008 and is headquartered in San Francisco, California.

Atlas Commerce

Venture Round in 2000
Atlas Commerce delivers Internet business applications for private eHubs. They're enabling global organizations to turn their existing business partnerships into competitive advantage by automating sourcing processes, improving management of supply and demand, and integrating commerce transactions across their entire value chain. They're demonstrating their expertise by supporting strategic sourcing of direct materials; multi-tier, multi-language, multi-currency commerce transactions; collaborative forecasting, planning, and replenishment; and XML integration with legacy applications and trading exchanges. They're proving their value by helping customers achieve increased revenue, lower cost of goods sold, improved margins, and faster customer response times. Atlas Commerce is a Safeguard Scientifics (NYSE:SFE) partner company. Safeguard is a leader in identifying, developing and operating premier technology companies in the Internet infrastructure market with a focus on three sectors: software, communications, and eServices. The Safeguard network consists of 49 direct holdings and an extended network of over 300 Internet-centric companies. Founded in January 1998, Atlas Commerce is headquartered in Malvern, PA, with offices worldwide. For additional information, please contact us at info@atlascommerce.com.

T-Rex Group, Inc.

Series B in 2017
Enterprise Fintech Platform: T-REX’s mission is to make complex capital markets more liquid through enhanced transparency and efficiency. In order to facilitate growth in complex asset classes, T-REX aims to continuously build effective market-relevant financial infrastructure that allows complex markets to be more robust through unprecedented transparency. T-REX is the financial and risk analytics platform for complex asset classes: increasing standardization, efficiency, and transparency. Through its enterprise SaaS platform, T-REX unlocks hundreds of billions of dollars currently seeking investment through modules that combine analysis across assets, loans, bonds, and other capital structures. Before T-REX, the value of the assets was opaque, non-standard, and manually evaluated one asset at a time. With T-REX, industry participants can now efficiently invest in, securitize, and manage portfolios of assets with complete transparency.

Trice Medical

Series C in 2019
Trice Medical is founded to fundamentally improve orthopedic diagnostics for the patient, physician, and payor by providing instant, eyes-on, answers. Trice has pioneered fully integrated camera-enabled technologies that provide a clinical solution that is optimized for the physicians office. Our mission is to provide more immediate and definitive patient care, eliminating the false reads associated with current indirect modalities and significantly reduce the overall cost to the healthcare system.

Avid Radiopharmaceuticals

Series C in 2007
Avid develops molecular imaging agents to aid medical management of chronic human diseases. They are located in Philadelphia, PA. Their mission is to develop new molecular imaging agents capable of changing the medical management of significant, chronic human diseases by identifying the first stages of pathological change, potentially assisting in earlier diagnosis, and better management and development of new therapies.

Pneuron

Series B in 2015
Pneuron overcomes the time, cost, and complexity challenges associated with traditional enterprise development, deployment and integration approaches. Using Pneuron’s Distributed Platform, organizations can leverage existing systems and infrastructure to connect data, applications, processes, and analytics without the need of intermediary databases, associated data integration costs or system replacement. In a single non-invasive “fabric” Pneuron allows the enterprise to manage the entire business solution lifecycle from a single screen – including development, deployment, integration, resiliency, availability and performance - freeing the enterprise to focus on realizing business value. The result is unprecedented productivity, engagement of business expertise, and reduced cost of success, inspiring new waves of innovation.

Syapse

Series B in 2014
Syapse works with leading health systems, life sciences companies, and regulators to accelerate real-world evidence to improve the outcomes of cancer patients. By bringing these organizations together into the Syapse Learning Health Network, Syapse has built one of the world’s largest networks dedicated to improving outcomes in cancer care through improved precision medicine. Syapse and its partners are working towards a future in which all cancer patients have access to the quality of care they need. The company was founded in 2008 and is headquartered in San Francisco, California.

Propeller Health

Series B in 2014
Propeller Health is a mobile platform that offers sensors, mobile apps, analytics, and services to support respiratory health management. The HIPAA compliant platform stores users’ data in a cloud computing infrastructure. The Propeller sensor and mobile application help users learn more about and better manage their asthma, COPD, and respiratory disease. The Propeller sensor attaches to users’ inhalers and wirelessly syncs with their smartphones. It tracks their triggers and symptoms and sends personalized feedback and education to their phones based on the symptoms. Users can see how often they use the medication, and set up medication reminders and alerts. Propeller community enables users to share their Propeller data with their physician and family members. Propeller Health is backed by Safeguard Scientifics, The Social+Capital Partnership, California HealthCare Foundation, and other investors.  The platform works with organizations such as Dignity Health, Wyckoff Heights Medical Center, Amerigroup Florida, and the City of Louisville. The system has been featured in The Economist, Washington Post, Fast Company, Wired, and Scientific American. Propeller Health has received TEDMED Innovation Showcase, White House Champion of Change, and Bluetooth Breakthrough Product awards. Propeller Health was launched by David Van Sickle, Greg Tracy, and Mark Gehring and its operations are based in Wisconsin, United States.

TechSpace

Venture Round in 2000
Techspace provides office space to entrepreneurs, startups, venture capitals, and small- to mid-sized businesses. These offices offer tech connectivity, with a private, firewalled data network, dedicated and burstable internet connectivity, advanced voice telecommunications, e-mail, web, and application hosting services. TechSpace was founded by Scott Blum in 1997 and is headquartered in Aliso Viejo, California.

Cellumen

Series B in 2007
Cellumen is the innovator in cellular systems biology (CSB™) solutions providing the most accurate predictions of drug efficacy and safety, thus reducing failure rates and cutting development costs. Cellumen’s CSB solutions are driving Discovery Toxicology by addressing the full complexity of disease and safety. Leading global organizations, such as the Mayo Clinic, Hamamatsu Photonics K.K., the EPA, FDA, NIH and top pharmaceutical companies, partner with Cellumen. Cellumen is a partner company of Safeguard Scientifics.

Syapse

Series C in 2016
Syapse works with leading health systems, life sciences companies, and regulators to accelerate real-world evidence to improve the outcomes of cancer patients. By bringing these organizations together into the Syapse Learning Health Network, Syapse has built one of the world’s largest networks dedicated to improving outcomes in cancer care through improved precision medicine. Syapse and its partners are working towards a future in which all cancer patients have access to the quality of care they need. The company was founded in 2008 and is headquartered in San Francisco, California.

Velano Vascular

Series A in 2015
Velano Vascular's technologies transform care by reducing the stress and anxiety related to blood draws during hospitalization. The company's needle-free device reduces pain and discomfort for patients, and enhances safety and efficiency for providers. Founded by a patient and a physician, Velano Vascular is backed by First Round Capital, Kapor Capital and White Owl Capital. The company’s collaborators include leading U.S. hospital systems and organizations innovating in patient-centered care.

MediaMath

Series C in 2014
MediaMath, Inc. develops and delivers digital advertising media and data management technology solutions to advertisers worldwide. The company’s TerminalOne platform activates data, automates execution, and optimizes advertising interactions across addressable media. Its Omnichannel programmatic marketing platform activates predictive audience to enhance one-to-one customer conversations; accesses Omnichannel media at scale to deliver relevance of context and message; closes the loop between measurement and optimization with machine learning; and leverages people in the business. The company also provides professional services in the areas of programmatic strategy and optimization, analytics, technology support, and advertising operations; and training and certification programs focusing on digital marketing. MediaMath, Inc. was founded in 2007 and is headquartered in New York, New York with additional offices in San Francisco and Santa Monica, California; Boston, Massachusetts; Chicago, Illinois; Miami, Florida; Durham, North Carolina; London, United Kingdom; Madrid, Spain; Berlin; Singapore; Tokyo, Japan; Sao Paulo, Brazil; Sydney and Melbourne, Australia; and Bengaluru, India.

Zipnosis, Inc.

Series A in 2016
Zipnosis, Inc. operates a virtual health care platform that connects patients and clinicians through phone and video interviews. The company also offers a ZipTicket, a healthcare boarding pass that provides patients with access to clinics for in-person assessments or lab tests. Zipnosis, Inc. has a strategic partnership with Upfront. The company was founded in 2008 and is based in Minneapolis, Minnesota.

NexTone Communications

Series D in 2005
NexTone Communications, headquartered in Rockville, Md., is focused on delivering Internet-based solutions for voice and data convergence to service providers. NexTone is in touch with the needs of the communications industry and is building products and solutions that facilitate the delivery of next generation applications. NexTone Communication's solutions represent what's next in convergence.

Trice Medical

Series B in 2014
Trice Medical is founded to fundamentally improve orthopedic diagnostics for the patient, physician, and payor by providing instant, eyes-on, answers. Trice has pioneered fully integrated camera-enabled technologies that provide a clinical solution that is optimized for the physicians office. Our mission is to provide more immediate and definitive patient care, eliminating the false reads associated with current indirect modalities and significantly reduce the overall cost to the healthcare system.

NuPathe, Inc.

Series A in 2006
NuPathe Inc., a specialty pharmaceutical company, focuses on the development and commercialization of branded therapeutics for neurological and psychiatric disorders. The company’s lead product is Zecuity, which is a sumatriptan iontophoretic transdermal system used for the acute treatment of migraine with or without aura in adults. Its pipeline product candidates include NP201 for the continuous symptomatic treatment of Parkinson's disease; and NP202 for the long-term treatment of schizophrenia and bipolar disorder. The company develops its products using SmartRelief, a proprietary transdermal medication delivery technology based on iontophoresis, a non-invasive method of actively transporting molecules, such as sumatriptan; and Long-Acting Delivery, a biodegradable polymer matrix, which uses medical polymers and an active drug combined to form a small implant for injection just below the skin. NuPathe Inc. was founded in 2005 and is based in Malvern, Pennsylvania. As of February 20, 2014, NuPathe, Inc. operates as a subsidiary of Teva Pharmaceutical Industries Limited.

Aktana

Series B in 2016
Aktana helps life science companies get the most out of artificial intelligence for commercializing their products. Its platform harnesses machine learning algorithms to enable marketing and sales teams to optimize their engagement with prescribing physicians. Aktana supports more than 100 brands and more than half the top 20 pharmaceutical companies worldwide to increase revenue, capitalize on data investments, and drive channel productivity and results. The company’s focus on the life sciences market allows Aktana to understand and incorporate unique market dynamics more deeply than the major AI players. Headquartered in San Francisco, Aktana also has offices in New York, Philadelphia, London, Barcelona, Tokyo, Osaka, and Shanghai.

Velano Vascular

Series B in 2017
Velano Vascular's technologies transform care by reducing the stress and anxiety related to blood draws during hospitalization. The company's needle-free device reduces pain and discomfort for patients, and enhances safety and efficiency for providers. Founded by a patient and a physician, Velano Vascular is backed by First Round Capital, Kapor Capital and White Owl Capital. The company’s collaborators include leading U.S. hospital systems and organizations innovating in patient-centered care.

Swaptree Inc.

Series C in 2008
Swaptree is a website that allows users to trade books, CDs, DVDs and video games with other users for freeSwaptree.com provides a platform for trading among its customers. The Company offers a site where the user can freely swap new and used DVDs, CDs, video games, and books with other members. Swaptree.com conducts services in the United States.

Prognos

Series C in 2017
Prognos is a healthcare AI company focused on eradicating disease by driving decisions earlier in healthcare in collaboration with payers, Life Sciences and diagnostics companies. The Prognos Registry is the largest source of clinical diagnostics information in over 30 disease areas, with over 5B medical records for 100M patients. Prognos has 500 extensive proprietary and learning clinical algorithms to enable earlier patient identification for enhanced treatment decision-making, risk management and quality improvement.

Alverix

Series A in 2008
Alverix focuses on producing low cost, handheld reader devices with the accuracy and precision of laboratory instrumentation. The company partners with diagnostic and OEM manufacturers seeking to increase current test accuracy, improve the portability of existing tests, or develop new assays for use in physician offices, laboratory outreach locations, retail clinics, and patient homes. With strength in product design, product development, and high volume manufacturing, Alverix is leading the transition of diagnostic testing from the laboratory to all locations where immediate results are critical to patient care.

Spongecell

Venture Round in 2016
Spongecell, Inc. designs, develops, and offers advertising technology tools and services. It transforms banner advertising into flash advertising with interactive features, such as video, interactive mapping, carousels, social media, and more. The company also provides interactive display space for consumer interaction and delivering brand engagement. It serves creatives, media, and brand advertisers. Spongecell, Inc. was founded in 2006 and is based in New York, New York. As of January 29, 2018, Spongecell, Inc. operates as a subsidiary of Simplicity Marketing Ltd.

Moxe Health

Series A in 2016
Moxe Health streamlines the bi-directional exchange of clinical data between health plans and provider systems. The company provide solutions for risk adjustment, HEDIS and Star ratings, claims denial management, HCC reconciliation, patient summary, ADT notifications, and care gap management. Plans seamlessly send back data and insights while never straying from clinicians’ EHR workflows. Moxe’s clinical data clearinghouse allows health plans to easily receive information from health systems. Health plans can then seamlessly send back data and insights. With automated solutions for risk adjustment, quality, and care management programs, Moxe facilitates access to the information essential to your success in the market shift to value-based care. Moxe’s neutrality in providing data connectivity lets you realize the full potential of your existing investments in population health, quality, and analytics solutions.

Quinnova Pharmaceuticals

Series B in 2009
Quinnova Pharmaceuticals, Inc., a specialty pharmaceutical company, engages in the development and commercial sale of prescription drug products based on dermal drug delivery platforms. It offers HYDRO 40 foam, a dry skin treatment product; tersi foam, a leave-on foam indicated for the treatment of seborrheic dermatitis and tinea versicolor; rinnovi nail system, a prescription nail system that is designed to clean, treat, and protect diseased, damaged, brittle, and ingrown nails; and cleanse and treat, a pad delivery technology system for the treatment of acne. Quinnova Pharmaceuticals, Inc. was founded in 2003 and is based in Newtown, Pennsylvania.
Molecular Biometrics, Inc., is applying novel metabolomic technologies to develop accurate, non-invasive methodologies for evaluating normal biologic function in health and disease, and for drug discovery and development. The company's proprietary technology is being applied in reproductive health, neurodegenerative disease (Alzheimer's disease and Parkinson's disease), maternal fetal medicine, pulmonary metabolism and edema, and lactate metabolism.

eMake

Series B in 2000
eMake offers a tightly integrated and secure environment for shop scheduling, managing production operations and publishing shop-floor data to the Internet.

AppFirst

Series B in 2012
AppFirst’s is a patented technology that provides a solution for collecting every event across web-scale applications, regardless of the infrastructure type or programming language. With microsecond visibility into all the applications and supporting resources across their shared infrastructure, IT Operations can now deterministically get to the root cause, effectively footprint applications to determine exactly what resources that application requires, and proactively identify when their applications become wobbly. Those responsible for the infrastructure finally have a way to continuously understand the performance of every application running on the shared-resources they own.

Lumesis, Inc.

Series B in 2014
Lumesis, Inc. operates as a Software-as-a-Service and cloud-based financial technology company that provides regulatory and data solutions for the municipal marketplace. It offers DIVER Analytics, a solution that provides clients with access to various datasets, as well as a suite of analytical and visualization tools that address the realities of the municipal marketplace, such as stale financials, fiscal uncertainty, and infrequent ratings. The company also offers DIVER Advisor, a solution that is used to support clients’ evolving regulatory needs that address time-of-trade disclosure, supervision, and suitability; DIVER Data Services, a solution that provides clients with access to data and custom datasets formatted and delivered to the platform; and DIVER Geo Score that represents the score of the economic health of a particular geographic area to assist users in understanding the overall economic health of a selected geographic area. It serves the U.S. banks, broker/dealers, asset managers, insurance companies, hedge funds, municipal index providers, credit analysts, portfolio managers, risk managers, legal and compliance professionals, financial advisors, and private wealth managers. Lumesis, Inc. was founded in 2010 and is based in Stamford, Connecticut.

Zipnosis, Inc.

Series B in 2018
Zipnosis, Inc. operates a virtual health care platform that connects patients and clinicians through phone and video interviews. The company also offers a ZipTicket, a healthcare boarding pass that provides patients with access to clinics for in-person assessments or lab tests. Zipnosis, Inc. has a strategic partnership with Upfront. The company was founded in 2008 and is based in Minneapolis, Minnesota.

PixelOptics

Series D in 2011
PixelOptics was founded in 2005 as the world's first composite lens company. Their unique and proprietary approach to lens design combines sound lens design principles and well-known, proven lens materials to create entirely new categories of eyeglass lenses.

Spongecell

Series B in 2012
Spongecell, Inc. designs, develops, and offers advertising technology tools and services. It transforms banner advertising into flash advertising with interactive features, such as video, interactive mapping, carousels, social media, and more. The company also provides interactive display space for consumer interaction and delivering brand engagement. It serves creatives, media, and brand advertisers. Spongecell, Inc. was founded in 2006 and is based in New York, New York. As of January 29, 2018, Spongecell, Inc. operates as a subsidiary of Simplicity Marketing Ltd.

Apprenda

Series C in 2013
Apprenda is a developer of a cloud-based enterprise platform used to power the next generation of enterprise software development. The company creates and supports modern, enterprise-ready application platforms for both cloud-native and traditional application workloads. With more than a decade of deep, enterprise customer insights, it provides compatible solution offerings for both individuals and IT departments, removing friction from the software delivery process and transforming IT into an engine of growth. Apprenda was established in 2007 and is headquartered in Troy, New York.