Bill & Melinda Gates Foundation

Vir Biotechnology, Inc. is a clinical-stage immunology company based in San Francisco, California, focused on developing therapeutic products to treat and prevent serious infectious diseases. The company employs a combination of innovative technologies and scientific expertise to enhance the immune response against pathogens. Its pipeline includes several product candidates, such as VIR-2218 and VIR-3434 for hepatitis B, VIR-2482 for influenza A, VIR-1111 for HIV, and VIR-2020 for tuberculosis. Vir's approach integrates various technology platforms, including antibodies, T cells, and small interfering RNA, to manipulate pathogen-host interactions. The company collaborates with multiple organizations, including the Bill & Melinda Gates Foundation, the National Institutes of Health, and several pharmaceutical companies, to advance its research and development efforts. Additionally, Vir has established agreements for the manufacturing of SARS-CoV-2 antibodies, positioning itself to address emerging infectious diseases. Founded in 2016, Vir Biotechnology aims to make significant advancements in the fight against viral diseases.

SpyBiotech Limited, founded in 2017 and based in Oxford, United Kingdom, specializes in the development of innovative vaccines through its proprietary biotechnology platform. The company utilizes a unique molecular superglue to bond antigens to viruses and other particles, facilitating the rapid creation of vaccines aimed at a variety of diseases. This advanced technology enables medical institutions and research centers to produce next-generation vaccines that demonstrate improved efficacy and reduced development time, thereby enhancing the overall vaccine development process.

Oxitec is a biotechnology company focused on developing environmentally friendly solutions for controlling insect pests that transmit diseases and damage crops. Founded in 2002 and based in Oxford, United Kingdom, the company utilizes proprietary technology derived from research at the University of Oxford. This technology enhances the traditional Sterile Insect Technique (SIT) by integrating genetics and molecular biology, making it more cost-effective and safe for a wider range of insect pests. Oxitec offers various genetically modified strains, including Aedes aegypti and Aedes albopictus, which target disease-carrying mosquitoes, as well as strains for agricultural pests like the Diamondback moth and Pink bollworm. These innovations aim to provide targeted, non-toxic, and scalable pest control solutions that protect public health, agricultural productivity, and ecosystems. The company also operates a mosquito production facility in Piracicaba, Brazil, contributing to its global efforts in pest management.

Yemaachi Biotechnology uses cutting-edge immunogenomics, bioinformatics, and artificial intelligence to accelerate the development of cancer detection and cure strategies for lowering the economic burden of cancer.

Particles for Humanity transforms early-stage medical technology into products for people living in low-resource settings. Its development plans include a portfolio of products for improving vaccination and reducing malnutrition. Its rigorous product development process is based on end-user input and is focused on financially sustainable product opportunities.

Reithera Srl is a company devoted to develop and produce biopharmaceutical products based on gene delivery technologies for advanced therapies, in order to prevent and treat several serious or life-threatening diseases.

Biotalys is a green biotech company that employs its proprietary Agrobody technology platform to develop crop protection products. The company develops a new generation of protein-based biocontrol solutions, shaping the future of sustainable and safe food supply. Biotalys' unique protein-based biocontrols combine the high-performance characteristics of chemicals with the clean safety profile of biologicals, making them ideal crop protection agents for both pre- and post-harvest applications. It was incorporated in 2012 and is based in Ghent, Belgium.

Provivi Inc. develops biopesticides for agriculture, commercial, household, and public health pest management. It develops research quantities of carbene/nitrene transferase enzymes that activate diazo and azide compounds to generate iron-carbenoids and iron-nitrenoids through a mode of activation. The company also develops a biocatalysis and fermentation technology, which is based on biocatalysts that enable efficient synthesis of biopesticides. Its technology has applications in industries, such as pharmaceuticals, nutrition, flavors, and fragrances. The company offers its products through distributors worldwide. Provivi Inc. was incorporated in 2012 and is based in Santa Monica, California.

CRISPR Therapeutics is focused on the development of transformative medicines using its proprietary CRISPR/Cas9 gene-editing platform. CRISPR/Cas9 is a revolutionary technology that allows for precise, directed changes to genomic DNA. They have licensed the foundational CRISPR/Cas9 patent estate for human therapeutic use from their scientific founder, Dr. Emmanuelle Charpentier, who co-invented the application of CRISPR/Cas9 for gene editing. CRISPR Therapeutics’ vision is to cure serious human diseases at the molecular level using CRISPR-Cas9. The company is headquartered in Basel, Switzerland and has operations in London, UK.

Particles for Humanity transforms early-stage medical technology into products for people living in low-resource settings. Its development plans include a portfolio of products for improving vaccination and reducing malnutrition. Its rigorous product development process is based on end-user input and is focused on financially sustainable product opportunities.

Daré Bioscience is a healthcare company committed to the development and commercialization of innovative products in women’s reproductive health.

Daré Bioscience is a healthcare company committed to the development and commercialization of innovative products in women’s reproductive health.

Particles for Humanity transforms early-stage medical technology into products for people living in low-resource settings. Its development plans include a portfolio of products for improving vaccination and reducing malnutrition. Its rigorous product development process is based on end-user input and is focused on financially sustainable product opportunities.

Biological Dynamics Inc. is an early-stage company based in San Diego, California, that focuses on developing a proprietary technology platform utilizing AC Electrokinetic technology for the direct and selective capture of large necrotic particles from physiological solutions, including whole blood, serum, and plasma. This innovative platform allows for the rapid extraction of large molecular weight particles that would not naturally settle. The company offers a range of diagnostic solutions, including the TR(ACE) Assay for monitoring treatment response and tumor burden across various cancers, as well as liquid biopsy testing for personalized medicine applications. Additionally, Biological Dynamics provides clinical laboratory services that encompass molecular and next-generation sequencing. Their technology supports various medical needs, including autoimmune disorders, transplant rejection, infectious diseases, and brain injuries, while also aiding in drug development for conditions like Alzheimer's disease. Founded in 2008, Biological Dynamics aims to enhance disease detection and intervention, ultimately improving patient outcomes and reducing healthcare costs.

RJH Biosciences focus on development of transfection reagents and delivery agents for nucleic acids. The company distributes its products via its website and undertakes projects on new medical treatments.

BCD Bioscience, Inc. designs and develops an oligosaccharide library and a roadmap that connects precise carbohydrate structures with their functions as prebiotics and immunomodulators to develop pharmaceutical and food ingredients. It offers a platform for creating and commercializing novel prebiotics, synbiotics, and immuno- modularity therapies for human and animal health. BCD Bioscience, Inc. was formerly known as Calyxo Biosystems, Inc. and changed its name to BCD Bioscience, Inc. in November 2019. The company was incorporated in 2019 and is based in Davis, California.

BioNTech is a biotechnology company based in Mainz, Germany, focused on developing and commercializing innovative immunotherapies for cancer and infectious diseases. Founded in 2008, BioNTech employs advanced computational discovery and therapeutic drug platforms to create novel biopharmaceuticals. The company has a diverse oncology pipeline, which includes various product candidates in clinical trials targeting different types of cancers, such as melanoma, prostate cancer, HPV-positive head and neck cancers, triple-negative breast cancer, and ovarian cancer. Additionally, BioNTech is exploring neo-antigen specific immunotherapies and mRNA-based treatments, along with novel immunomodulators and therapies for rare diseases. The company collaborates with several major pharmaceutical firms to enhance its research and development efforts. BioNTech also operates a subsidiary in the United States, developing targeted therapies for solid tumors.

Biological Dynamics Inc. is an early-stage company based in San Diego, California, that focuses on developing a proprietary technology platform utilizing AC Electrokinetic technology for the direct and selective capture of large necrotic particles from physiological solutions, including whole blood, serum, and plasma. This innovative platform allows for the rapid extraction of large molecular weight particles that would not naturally settle. The company offers a range of diagnostic solutions, including the TR(ACE) Assay for monitoring treatment response and tumor burden across various cancers, as well as liquid biopsy testing for personalized medicine applications. Additionally, Biological Dynamics provides clinical laboratory services that encompass molecular and next-generation sequencing. Their technology supports various medical needs, including autoimmune disorders, transplant rejection, infectious diseases, and brain injuries, while also aiding in drug development for conditions like Alzheimer's disease. Founded in 2008, Biological Dynamics aims to enhance disease detection and intervention, ultimately improving patient outcomes and reducing healthcare costs.

A biotechnology company focused on the discovery of novel vaccines and therapeutics for emerging infectious diseases. It antiviral pipeline includes unique pan-filovirus antibody candidates, vaccines and a variety of other product candidates for emerging viruses.

Univercells SA, founded in 2013 and based in Gosselies, Belgium, specializes in the design, development, and implementation of single-use bioprocess solutions for biomanufacturing. The company offers a comprehensive range of services, including the design and construction of manufacturing facilities, as well as the maintenance and supply of bulk active pharmaceutical ingredients (APIs). With a focus on vaccines and biologics, Univercells employs innovative engineering techniques that significantly reduce investment needs by over 75% and lower production costs by up to 90%. Their approach integrates three manufacturing steps—cell culture under perfusion, clarification, and capture—into a simulated continuous mode, enhancing efficiency in the production of antibodies, proteins, and vaccines. Additionally, Univercells has established a strategic partnership with Takeda Pharmaceutical Company to further advance its capabilities in the biomanufacturing sector.

Making nature accessible and affordable for a growing society.It is estimated that the world’s population will increase by more than 35% by 2050, reaching 9 billion people. Crop production will need to more than double in order to feed these people and meet the consumer needs of a developing world. With very little land remaining for agricultural expansion, they as a society need to find ways to maximize the use of their world’s resources. Plants produce a variety of rare natural products which are used in their daily lives as flavors, fragrances, food ingredients, cosmetics, vitamins, pharmaceuticals and agricultural chemicals. They strive to reduce their dependence on land- and resource-intensive practices by recreating natural processes through biotechnology.

Particles for Humanity transforms early-stage medical technology into products for people living in low-resource settings. Its development plans include a portfolio of products for improving vaccination and reducing malnutrition. Its rigorous product development process is based on end-user input and is focused on financially sustainable product opportunities.

Vedanta Biosciences is a developer of immunotherapies designed to treat immune-mediated and infectious diseases. The company's immunotherapies include a suite of proprietary assays to select pharmacologically potent strains, vast proprietary datasets from human interventional studies, and facilities for cGMP-compliant manufacturing of rationally-defined bacterial consortia in powder form, enabling physicians to access live bacteria drug to treat autoimmune and inflammatory diseases easily. It was founded in 2010 and is headquartered in Cambridge, Massachusetts.

DelSiTech, Ltd. engages in developing and licensing long-term controlled drug delivery implants, subcutaneous, and intramuscular formulations. It offers silica-based implants, subcutaneous, and intra-muscular injectable technology for controlled release of small molecular drugs and biopharmaceuticals. The company’s drug delivery products inject proteins, polysaccharides, and viruses. DelSiTech, Ltd. was founded in 2001 and is based in Turku, Finland.

Oxitec is a biotechnology company focused on developing environmentally friendly solutions for controlling insect pests that transmit diseases and damage crops. Founded in 2002 and based in Oxford, United Kingdom, the company utilizes proprietary technology derived from research at the University of Oxford. This technology enhances the traditional Sterile Insect Technique (SIT) by integrating genetics and molecular biology, making it more cost-effective and safe for a wider range of insect pests. Oxitec offers various genetically modified strains, including Aedes aegypti and Aedes albopictus, which target disease-carrying mosquitoes, as well as strains for agricultural pests like the Diamondback moth and Pink bollworm. These innovations aim to provide targeted, non-toxic, and scalable pest control solutions that protect public health, agricultural productivity, and ecosystems. The company also operates a mosquito production facility in Piracicaba, Brazil, contributing to its global efforts in pest management.

Evolve Biosystems is a biotechnology company that specializes in providing microbiome-based products designed to develop, restore, and maintain. The company's platform focuses on solving the gut dysbiosis throughout the human life cycle as well as in various animal species, enabling physicians to maintain the healthy gut microbiome in newborn infants with a consumer-directed home use product, and a hospital-based neonatal ICU product. It was founded in 2011 and headquartered in Davis, California.

Recursion Pharmaceuticals is a biotechnology company based in Salt Lake City. Recursion combines experimental biology, automation, and artificial intelligence in a massively parallel system to quickly and efficiently identify treatments for any disease which can be modeled at the cellular level. From its initial and continued focus on drug repurposing to treat rare diseases, Recursion has broadened its platform to probe rich data from high-throughput automated screens for a number of indications, including aging, inflammation, infectious disease, and immunology. Recursion is aggressively leveraging technology to build a robust and reliable map of human cellular biology, which will enable a radical shift in the pace and scale at which new treatments will benefit patients.

Making nature accessible and affordable for a growing society.It is estimated that the world’s population will increase by more than 35% by 2050, reaching 9 billion people. Crop production will need to more than double in order to feed these people and meet the consumer needs of a developing world. With very little land remaining for agricultural expansion, they as a society need to find ways to maximize the use of their world’s resources. Plants produce a variety of rare natural products which are used in their daily lives as flavors, fragrances, food ingredients, cosmetics, vitamins, pharmaceuticals and agricultural chemicals. They strive to reduce their dependence on land- and resource-intensive practices by recreating natural processes through biotechnology.

Ventria Bioscience, Inc. is a biotechnology company based in Fort Collins, Colorado, specializing in the development, manufacturing, and marketing of health and nutrition products. Founded in 1993, the company focuses on human nutrition and therapeutics, offering a range of products that includes lactoferrin and lysozyme glycoproteins, which are utilized for gastrointestinal health and the dietary management of acute diarrhea, as well as for treating topical infections and fungal conditions. Ventria also provides OptiVERO, a specialized cell culture media for vaccine manufacturing, and operates a BioShare program that grants researchers access to recombinant proteins and peptides for various research applications. The company leverages its patented ExpressTec technology, which enhances recombinant protein yield through a plant-based manufacturing process, enabling the development of new biotherapeutics, vaccines, and other biomanufacturing reagents.

Immunethep, SA is a biotechnology company based in Cantanhede, Portugal, focused on developing therapies for immune system-related pathologies. A spin-off from the University of Porto, Immunethep utilizes proprietary technology to address unmet medical needs in the field of infectious diseases. The company has identified a novel mechanism employed by various pathogenic bacteria that suppresses the host immune response. By targeting this mechanism, Immunethep is working on developing broad coverage anti-bacterial immunotherapies. One of the key projects includes the creation of neonatal vaccines designed to protect newborns from bacterial infections that can lead to severe health complications, such as sepsis. This innovative approach aims to enhance immunity in neonates and prevent multi-bacterial infections, contributing to advancements in healthcare.

Boragen Inc. is a biotechnology company based in Durham, North Carolina, that specializes in designing and developing multifunctional small molecule boron solutions for applications in crop protection, animal health, and human health. Founded in 2015, the company focuses on creating next-generation fungicides through its synthetic chemistry platforms, which aim to promote sustainable farming practices. Boragen's product pipeline includes BAG8, a boron-based multisite fungicide, and BN2266, which targets mRNA processing as a crop protection fungicide. Additionally, the company is developing a dual-function nematicide-fungicide designed for root protection and endo-parasiticides that address resistance challenges. Through its innovative approach, Boragen seeks to enhance agricultural efficiency while minimizing chemical usage.

Vaxess Technologies, Inc. is a biotechnology company based in Boston, Massachusetts, founded in 2011. It specializes in developing and commercializing silk biomaterial technologies aimed at improving vaccine delivery and storage. The company has created the MIMIX microneedle platform, which facilitates transdermal delivery of vaccines and therapies, and the MATRIX formulation and drying platform, which enhances the stability of vaccines, therapeutics, and diagnostic products. By utilizing a silk-derived protein, Vaxess enables vaccines to be stored and transported without refrigeration, thereby reducing distribution costs and increasing access to essential healthcare products globally.

Vir Biotechnology, Inc. is a clinical-stage immunology company based in San Francisco, California, focused on developing therapeutic products to treat and prevent serious infectious diseases. The company employs a combination of innovative technologies and scientific expertise to enhance the immune response against pathogens. Its pipeline includes several product candidates, such as VIR-2218 and VIR-3434 for hepatitis B, VIR-2482 for influenza A, VIR-1111 for HIV, and VIR-2020 for tuberculosis. Vir's approach integrates various technology platforms, including antibodies, T cells, and small interfering RNA, to manipulate pathogen-host interactions. The company collaborates with multiple organizations, including the Bill & Melinda Gates Foundation, the National Institutes of Health, and several pharmaceutical companies, to advance its research and development efforts. Additionally, Vir has established agreements for the manufacturing of SARS-CoV-2 antibodies, positioning itself to address emerging infectious diseases. Founded in 2016, Vir Biotechnology aims to make significant advancements in the fight against viral diseases.

Univercells SA, founded in 2013 and based in Gosselies, Belgium, specializes in the design, development, and implementation of single-use bioprocess solutions for biomanufacturing. The company offers a comprehensive range of services, including the design and construction of manufacturing facilities, as well as the maintenance and supply of bulk active pharmaceutical ingredients (APIs). With a focus on vaccines and biologics, Univercells employs innovative engineering techniques that significantly reduce investment needs by over 75% and lower production costs by up to 90%. Their approach integrates three manufacturing steps—cell culture under perfusion, clarification, and capture—into a simulated continuous mode, enhancing efficiency in the production of antibodies, proteins, and vaccines. Additionally, Univercells has established a strategic partnership with Takeda Pharmaceutical Company to further advance its capabilities in the biomanufacturing sector.

AgBiome, LLC is a biotechnology company based in Durham, North Carolina, that focuses on developing innovative biological products for the agriculture industry. Founded in 2012, AgBiome utilizes advanced genomics and screening technologies to identify plant-associated microbes that enhance plant health, pest resistance, and crop yields. The company manufactures fungicides to protect crops from soil-borne and foliar diseases while also employing a platform that captures and screens diverse microbes for their effectiveness against insects, diseases, and nematodes. AgBiome collaborates with leading agricultural firms to accelerate its discovery process and deliver solutions that address critical challenges in global food production. With a workforce of approximately 87 employees and a state-of-the-art laboratory and greenhouse facility in the Research Triangle Park, AgBiome aims to provide sustainable and effective solutions for farmers facing significant agricultural issues.

Batavia Biosciences focuses on accelerating the transition of biopharmaceutical product candidates from discovery to the clinic with improved success and lower cost. Our services cover candidate selection, production of research materials, upstream and downstream process development, assay development, product characterization and clinical manufacturing and release. Batavia Biosciences has successfully worked on viral and bacterial vaccines, recombinant proteins, antibodies and gene therapy products. Unique technologies such as STEP® protein expression technology and SCOUT® high throughput process technology accelerate timelines and reduce costs.

Just Evotec Biologics was founded in 2014 and acquired by Evotec in 2019. The company has an intense focus on the design of innovative and integrated technologies to accelerate the development of biotherapeutics and reduce their manufacturing cost. Core strengths include antibody discovery, molecular design, process and product design and manufacturing plant design.

Pivot Bio is a biotechnology company founded in 2010 and based in Emeryville, California. The company specializes in advancing crop nutrition through a deep understanding of the microbiome. By leveraging engineering principles and data science, Pivot Bio develops innovative solutions that utilize naturally occurring microbes to enhance crop yield and quality. Their proprietary ON Technology aims to provide essential nutrients to crops, specifically focusing on enabling microbes to fix and supply nitrogen for corn. This approach seeks to offer a sustainable alternative to traditional chemical fertilizers and pesticides, helping farmers improve their yields while addressing the nutritional needs of the growing global population. Through collaboration and communication, Pivot Bio is dedicated to transforming agricultural practices and contributing to a healthier planet.

Moderna, Inc. is a biotechnology company based in Cambridge, Massachusetts, founded in 2010. It specializes in the development of therapeutics and vaccines utilizing messenger RNA technology, which instructs cells to produce proteins essential for various biological functions. The company's extensive pipeline includes 40 mRNA development candidates targeting a range of therapeutic areas such as infectious diseases, oncology, cardiovascular diseases, and rare genetic disorders. Moderna gained significant recognition with its COVID-19 vaccine, which was authorized for use in the United States in December 2020. The company maintains strategic partnerships with organizations such as AstraZeneca, Merck & Co., and the Bill & Melinda Gates Foundation, enhancing its research capabilities and manufacturing processes. Additionally, it has research collaborations with esteemed institutions like Harvard University.

AgBiome, LLC is a biotechnology company based in Durham, North Carolina, that focuses on developing innovative biological products for the agriculture industry. Founded in 2012, AgBiome utilizes advanced genomics and screening technologies to identify plant-associated microbes that enhance plant health, pest resistance, and crop yields. The company manufactures fungicides to protect crops from soil-borne and foliar diseases while also employing a platform that captures and screens diverse microbes for their effectiveness against insects, diseases, and nematodes. AgBiome collaborates with leading agricultural firms to accelerate its discovery process and deliver solutions that address critical challenges in global food production. With a workforce of approximately 87 employees and a state-of-the-art laboratory and greenhouse facility in the Research Triangle Park, AgBiome aims to provide sustainable and effective solutions for farmers facing significant agricultural issues.

Synlogic, Inc. is a clinical-stage biopharmaceutical company based in Cambridge, Massachusetts, specializing in the discovery and development of synthetic biotic medicines aimed at treating metabolic, inflammatory, and cancer-related diseases. The company’s lead therapeutic program, SYNB1618, is an oral therapy currently in Phase I/IIa clinical trials for the treatment of phenylketonuria. Additionally, Synlogic is developing SYNB1891, an intratumoral synthetic biotic medicine that is undergoing Phase I clinical trials for the treatment of solid tumors and lymphoma. The company is also exploring synthetic biotics for more common conditions, including inflammatory bowel disease and secondary hyperoxaluria. Synlogic has established a collaboration with Ginkgo Bioworks to advance its development of these innovative therapies.

Tetragenetics, Inc. is an early-stage biotechnology company meeting the needs of customers who seek a cost-effective alternative platform technology for the production of genetically engineered proteins. Their technology is particularly well suited to the production of eucaryotic membrane and secretory proteins that are difficult to express in conventional systems. Such proteins include vaccine antigens, monoclonal antibodies, and a variety of therapeutic proteins for the treatment and prevention of human and animal disease.

BlueWillow Biologics is a privately-held biopharmaceutical company focused on developing and commercializing intranasal vaccines, based on its patented nanotechnology platform. The company was originally founded as NanoBio Corporation, a spin-off from the Center for Biologic Nanotechnology at the University of Michigan, and was initially focused on developing nano-scale dermatology applications. Based on promising research generated under several Gates Foundation and NIH contracts, the company underwent a strategic “pivot” in 2016–17 to refocus its nanotechnology platform on the development of intranasal vaccines for respiratory and sexually transmitted diseases.

Tetragenetics, Inc. is an early-stage biotechnology company meeting the needs of customers who seek a cost-effective alternative platform technology for the production of genetically engineered proteins. Their technology is particularly well suited to the production of eucaryotic membrane and secretory proteins that are difficult to express in conventional systems. Such proteins include vaccine antigens, monoclonal antibodies, and a variety of therapeutic proteins for the treatment and prevention of human and animal disease.