MassVentures is a venture capital firm based in Waltham, Massachusetts, established in 1978 as a quasi-public corporation by the Massachusetts Legislature. The firm focuses on providing seed and early-stage funding to high-growth startups, facilitating their transition from concept to commercialization. MassVentures invests primarily in sectors such as information technology, healthcare, cybersecurity, e-commerce, mobile, manufacturing, and robotics. With a governance structure that includes an independent Board of Directors and management by experienced venture capitalists, MassVentures leverages the state's entrepreneurial spirit and innovation centers to support the Massachusetts innovation economy. The firm also offers accelerator programs to further assist emerging companies in their growth journey.

Founded in Boston in 2004, RA Capital is an investment firm specializing in life sciences and drug development. Its team, with backgrounds in biology, chemistry, medicine, and industry experience, invests in early-stage companies with promising technologies and products across healthcare and life science sectors.

Polaris Partners is a venture capital firm based in Boston, Massachusetts, with offices in San Francisco. Founded in 1996, it targets investments in technology and life science companies across the United States and Europe, supporting startups from early formation to profitable growth. The firm's healthcare and biotechnology focus encompasses digital health, consumer-centric care delivery, patient-provider solutions, data science and analytics, as well as therapeutics, genomics and other life science platforms. It backs companies across business-to-business and business-to-consumer models, software as a service, healthcare information technology and health tech sectors, partnering with repeat entrepreneurs to build durable, scale-ready businesses.

Atlas Venture is an early-stage venture capital firm based in Cambridge, Massachusetts, specializing in life sciences and biotechnology. It supports the translation of high-impact scientific discoveries into medicines for patients through a seed-led venture creation strategy that identifies and builds scalable companies with strong scientific foundations. The firm combines experienced scientists and career venture capitalists to select compelling opportunities and realize value, emphasizing early-stage investments in life sciences and technology. Atlas Venture also maintains a multi-disciplinary team able to advance startups from concept to clinical development and commercial viability.

Founded in 2000, General Catalyst is a venture capital firm specializing in early-stage and growth equity investments. It focuses on accelerating ideas, careers, and companies towards success by providing ongoing momentum and mentorship based on deep experience.

Alumni Ventures Group is a venture capital firm based in Manchester, New Hampshire, with offices across North America. It provides access to venture investing for individual accredited investors, particularly alumni networks, by offering diversified portfolios of venture opportunities and allowing members to invest alongside fellow alumni in ventures led by peers. The firm backs early-stage and later-stage opportunities across technology, consumer, healthcare, financial services, and other sectors, with a sector- and geography-agnostic approach. It typically invests between $10,000 and $3 million per deal and emphasizes the involvement of alumni connections and an institutional lead investor in opportunities. Alumni Ventures also offers focused funds to broaden participation, enabling accredited investors to access venture portfolios diversified by type, sector, stage, and geography. The model aims to democratize access to venture capital while maintaining rigorous selection standards through alumni networks.

Accomplice is a Boston-based venture capital firm, with an additional office in San Francisco, specializing in seed and early-stage investments in technology startups. It primarily invests in companies focused on cybersecurity, eSports, data analytics, SMB class software, emerging hardware platforms, and marketplaces. Accomplice uniquely leverages community platforms like AngelList, Boston Syndicates, and Maiden Lane to empower and fund exceptional founders. With a majority of its investments in Boston and additional investments throughout the U.S., Canada, and the E.U., Accomplice is one of the most active early-stage firms in New England.

Founder Collective is a seed and early-stage venture capital firm founded in 2009 with roots in Cambridge, Massachusetts and offices in New York. The firm is built by entrepreneurs who have founded and exited technology companies, and it aims to back founders by providing practical capital and guidance to navigate the risks of venture funding. It concentrates on early investments in technology companies, with an emphasis on software and information technology, and it makes bets across the United States and beyond, though its roots are on the East Coast. The team partners with portfolio companies to help them scale, often supporting startups that seek modest initial financings. Through its network and hands-on approach, Founder Collective seeks to partner with ambitious teams to grow durable, technology-driven businesses.

New Enterprise Associates is a venture capital firm founded in 1977 and based in Menlo Park, California, with offices in the United States, India and China. It makes investments across technology and healthcare startups at multiple stages, from seed to growth, including software, cloud, data, internet services, fintech, AI, e-commerce, and enterprise technology, as well as healthcare information technology, life sciences, medical devices, and biopharma. It also considers energy technology and infrastructure opportunities, such as solar, batteries and smart grids. The firm pursues a global approach, with activity in the United States, Asia and other regions, and supports companies through rounds of financing ranging from small to sizable investments as they scale. NEA focuses on building portfolios in software, IT services, consumer technology, and healthcare technology, backing ambitious entrepreneurs across sectors and geographies.

Founded in 1986, Morningside Group is a venture capital firm based in the greater Boston area. It invests in companies with innovative science and technology across life sciences, digital health, AI, materials, and technology sectors.

Founded in 1986, ARCH Venture Partners is a venture capital firm specializing in investments that bring innovations in life sciences to market. It focuses on companies co-founded by scientists and entrepreneurs, with a strong track record in commercializing technologies from academic research institutions and national laboratories.

Insight Partners is a global software investor that partners with growth-stage technology and software companies. The firm focuses on growth-stage software, internet, and data services, with emphasis on fintech, cybersecurity, artificial intelligence and machine learning, DevOps, and healthcare. Based in New York City with offices in London, Tel Aviv, and Palo Alto, Insight Partners has backed more than 750 companies worldwide and has more than 55 portfolio companies that have achieved an IPO. As of 2022, the firm reports over $75 billion in assets under management. It seeks to fund and work closely with visionary executives, providing practical, hands-on software expertise to support growth from initial investment through to IPO.

Founded in 1989, OrbiMed is a New York-based healthcare-dedicated investment firm managing approximately $5 billion in assets. It invests across the spectrum of healthcare companies, from private start-ups to large multinational corporations, focusing on biopharmaceuticals, life sciences, digital health, medical devices, and diagnostics sectors globally.

Alexandria Venture Investments is the strategic venture capital arm of Alexandria Real Estate Equities. Based in Pasadena, California, it provides long-term strategic capital to innovative life sciences and technology companies developing breakthrough therapies, diagnostics, and platforms across biopharma, digital health, agrifoodtech, agtech, and related healthcare fields. Established in 1996, the firm invests across seed, early, and growth stages and leverages its deep industry knowledge, extensive investor networks, and scientific advisory resources to support portfolio companies. The unit also pursues opportunities at the intersection of real estate, life sciences, and technology, reflecting its parent company's sector focus and integrated ecosystem approach. It aims to help entities advance human health by partnering with founders to scale transformative technologies.

Boston-based venture capital firm founded in 2005 that focuses on early-stage and select growth investments in information technology and related services. The firm backs enterprise IT companies, emphasizing information security, cloud infrastructure, data analytics, and software-as-a-service models, as well as technology-enabled business services and digital health, and it also targets healthcare IT, fintech, mobile software, and next-generation software. It prefers open source and SaaS delivery. Typically investing initial rounds of 2 to 5 million and totaling 6 to 10 million per company, it seeks board representation and often serves as lead or first institutional investor, with minority to majority stakes ranging from 20 to 80 percent. The firm reserves capital for opportunistic investments in more mature companies where its team has prior experience and focuses on opportunities in the Northeast United States.

Flagship Pioneering is a Cambridge, Massachusetts-based venture creation firm that conceives, creates, resources, and grows first-in-category companies across health technology, biotechnology, medicine, engineering, energy, and related fields. The organization aims to transform human health and sustainability by turning seemingly unreasonable ideas into transformational ventures through an evolutionary, science-driven approach. It combines inventive capacity, entrepreneurial leadership, and capital management within a single enterprise to systematically build new companies that pursue breakthrough advances in biology, engineering, and medicine. Since its founding in 2000, Flagship Pioneering has developed and nurtured a portfolio of ventures by integrating scientific discovery with disciplined entrepreneurship, seeking to accelerate innovations from concept to market.

Founded in 1969, F-Prime Capital is a venture capital firm based in Cambridge, Massachusetts. It invests globally in technology and healthcare sectors, supporting entrepreneurs with its extensive domain expertise and relationships.

Mission BioCapital is a life science venture capital firm investing in early-stage companies within the biotechnology sector. Founded in Cambridge, Massachusetts in 2009, the company is known for its experienced leadership team and deep support provided to portfolio companies.

Battery Ventures is a technology-focused investment firm founded in 1983 and based in Boston, Massachusetts. It engages in venture capital and private equity investments in technology companies, with emphasis on software (including application and infrastructure software), IT infrastructure technologies, consumer internet and mobile services, industrial technologies, and life science tools. The firm seeks to back category-defining businesses with potential for scalable growth, often supporting companies through multiple stages and across select global regions.

Casdin Capital is a New York‑based investment firm founded in 2012 by Eli Casdin. The firm specializes in fundamental research and long‑short equity strategies focused on the life sciences and healthcare sectors, including oncology, digital health, and agtech. In addition to its public‑market fund, Casdin Capital invests in early‑stage to late‑stage private companies within these industries. It operates as a Registered Investment Adviser and, as of October 2020, managed approximately $2.2 billion in assets.

Walnut Ventures is a venture capital firm headquartered in Boston, Massachusetts, that focuses on investing in seed and early-stage companies, primarily within the information technology sector. The firm is particularly interested in areas such as home entertainment software, data processing, online services, and internet marketing. It typically invests between $250,000 and $1 million in companies located in the New England region and aims to take an active role by seeking a board seat in its portfolio companies. Established in 1997, Walnut Ventures comprises a network of experienced entrepreneurs and investors who are dedicated to helping talented entrepreneurs build sustainable businesses in rapidly growing markets. The firm offers not only financial investment but also support in refining business plans, enhancing management teams, developing financing strategies, and facilitating strategic partnerships.

SV Health Investors is a venture capital and growth equity firm focused on healthcare and life sciences. Headquartered in the United States with offices in Boston, San Francisco and London, the firm supports entrepreneurs who develop breakthrough medicines, devices and related technologies. It manages multiple private healthcare funds and has a 20-year track record in the US and Europe, investing across North America and Western Europe to advance innovative treatments and diagnostics. SV Health Investors aims to transform healthcare by backing early-stage and growth opportunities in biotechnology, medical devices and related sectors.

Founded in 2005, Spark Capital is a venture capital firm that invests across various sectors and stages. Known for embracing risk, the firm supports founders of exceptional products to achieve success on their own terms. Notable investments include Twitter, Discord, Cruise, Niantic, Oculus, Warby Parker, and Tumblr.

Third Rock Ventures is a Boston-based venture capital firm that specializes in start-up and early-stage investments in life sciences companies, including biotechnology, pharmaceuticals, medical devices, diagnostics, therapeutics, and related information technology and data applications. Founded in 2007, the firm focuses on transformational ventures in the United States and commonly makes substantial initial investments, often leading rounds and pursuing strategic collaborations with larger pharmaceutical and biotechnology companies. It emphasizes active involvement in its portfolio, sometimes taking key management roles to accelerate development, and seeks to support companies through strategic partnerships, milestones, and scale-up efforts. While headquartered in Boston, it maintains a presence in San Francisco to engage with the broader life sciences ecosystem.

Matrix Partners is a venture capital firm founded in 1977 and based in San Francisco that backs early-stage and Series A technology companies across sectors such as artificial intelligence, B2B software, consumer technology, fintech, health tech, infrastructure, and semiconductors. The firm emphasizes practical, founder-centered collaboration, often supporting concepts from idea stage through Series A and taking board seats to help portfolio companies scale. It operates globally, including Matrix Partners China, which focuses on long-term relationships with entrepreneurs in China and has a track record of IPOs and strategic exits. The team combines former founders and experienced investors to bring local execution and global perspective. Notable investments span across the technology landscape, reflecting a history of involvement with companies like FedEx, Apple, Oculus, Canva, Zendesk, HubSpot, Postmates, Fivetran, Sila, and GOAT, illustrating the firm’s ability to support companies from early development to scale.

Founded in 1995, SOSV is a global venture capital firm headquartered in New Jersey. It focuses on seed-to-growth stage investments in deep tech innovations, primarily in bio-tech/life sciences and hardware/robotics sectors, with a commitment to human and planetary health.

Beacon Angels is a Boston-based angel group founded in 2006 that specializes in investing in early-stage and fast-growing companies in New England. The firm focuses on making investments ranging from $100,000 to $300,000, targeting businesses with high growth potential. Through its investment strategy, Beacon Angels aims to support and foster the development of small companies, contributing to the entrepreneurial landscape in the region.

Pillar VC is a Boston-based venture capital firm established in 2016 that provides early capital and supports founders from inception through growth. It backs university spinouts led by first-time founders as well as serial entrepreneurs, aiming to build meaningful, scalable companies. The firm focuses on high-potential ventures across machine intelligence, AI, hardware, enterprise software, blockchain, quantum, digital health, and synthetic biology, and offers connections, coaching, and a community to help founders develop personally and professionally. Pillar VC is open to ventures of various types and emphasizes hands-on support and collaboration to accelerate progress.

Accel is a venture capital firm founded in 1983 and based in Palo Alto, California, with additional offices in San Francisco, London, and Bangalore. It focuses on early and growth-stage technology startups, investing across software, cloud, data analytics, mobile technology, consumer services, fintech, security, healthcare, and information technologies. Accel seeks to partner with entrepreneurs to build world-class companies that define new categories and drive growth. Its portfolio includes notable technology companies such as Atlassian, Dropbox, Slack, Spotify, Etsy, Cloudera, DJI, Braintree, and Lookout Security, among others.

Khosla Ventures is a California-based venture capital firm founded in 2004 by Vinod Khosla. It provides capital and strategic guidance to startups across stages, focusing on technology-driven companies in areas such as artificial intelligence, climate and sustainability, enterprise software and services, fintech, digital health, medical technology and diagnostics, therapeutics, consumer products, and frontier technologies. The firm backs bold ventures with the potential to disrupt markets and improve lives, supporting companies from early to growth stages and working closely with entrepreneurs to apply science, technology and innovative business models. While primarily investing in North American technology companies, Khosla Ventures pursues opportunities globally and emphasizes experimentation and impact alongside financial returns. The firm also maintains related impact initiatives that support entrepreneurs addressing socio-economic challenges in emerging markets.

Founded in 2015, Underscore.VC is a Boston-based venture capital firm focusing on seed to series A investments. It primarily invests in technology companies with an emphasis on sensor-related technologies, software for factories and home automation, healthcare infrastructure, data storage databases, and cloud-based marketing/commerce software.

Founded in 1911, Bessemer Venture Partners is a venture capital firm based in Redwood City, California. With over $4 billion under management, the firm invests globally across various sectors including artificial intelligence & machine learning, biotech, cloud, consumer, cybersecurity, deep tech, developer, fintech, healthcare, marketplaces, and vertical software. Known for its long-standing support of entrepreneurs, Bessemer has backed companies such as Pinterest, Shopify, Twilio, Yelp, and Linkedin.

Boston Seed Capital is a seed- and early-stage venture capital firm based in Massachusetts, with offices in Boston and Wellesley Hills. Founded in 2010, it focuses on funding internet-enabled and technology-driven startups across the United States, including consumer products, B2B software as a service, cybersecurity, e-commerce, big data, artificial intelligence and machine learning, marketplaces, and related services. The firm backs early-stage companies, often in information technology and SaaS, providing capital and strategic support to help companies scale from initial traction to growth.

Morningside is a venture capital firm based in the greater Boston area, specializing in investments in companies that focus on innovative science and technology. Established in 1986 as a family office for the Chan family, Morningside emphasizes a long-term approach to company-building and maintains a strong commitment to ethical practices. The firm is staffed by a team of experienced investment professionals with expertise in various sectors, including life sciences, digital health, artificial intelligence, materials, and technology. In addition to its investment activities, Morningside is dedicated to philanthropic efforts, supporting education, research, and healthcare initiatives such as the Harvard T.H. Chan School of Public Health, UMass Chan Medical School, and the MIT Morningside Academy for Design.

Eli Lilly and Company is a global pharmaceutical leader engaged in the discovery, development, manufacture, and sale of medicines. It operates facilities in the United States, Puerto Rico, and many other countries, with products sold in about 135 countries. The company focuses on therapies in neuroscience, cardiometabolic, cancer, and immunology, and also conducts research in animal health and animal agriculture. Lilly supports patient outcomes and education through a philanthropic foundation that funds programs in underserved communities, including STEM education in Indianapolis.

Hyperplane I, established in 2016, is a venture capital fund based in Boston, Massachusetts. It invests in exceptional founders developing machine intelligence and data companies, focusing on those that leverage AI, sensor technology, and cloud computing to tackle complex global challenges. The fund, managed by Hyperplane Venture Capital, was founded by Vivjan Myrto, John Murphy, and Brendan Kohler in 2015.

Invus Financial Advisors, LLC is an employee-owned investment firm based in New York, founded in 2006. The firm specializes in private equity investments and manages pooled investment vehicles, including hedge funds and funds of funds. Invus focuses on making direct and indirect investments in special situations, venture capital, and growth equity stages, with an emphasis on smaller companies and opportunistic co-investments. The firm adopts a flexible approach, recognizing the uniqueness of each company and the complexities of business transformation. Invus maintains a long-term commitment to its investments, aligning its incentives with those of its partners. With a history of empowering owner-managers since 1985 and a strong backing from a group of European families, Invus Financial Advisors manages over $4 billion in an evergreen fund and operates additional offices in London, Paris, and Hong Kong.

Launchpad Venture Group, based in Boston, Massachusetts, is an angel investment group that funds early-stage, technology-driven startups. They focus on innovative companies addressing substantial market opportunities, primarily in sectors like software, IT, healthcare, and clean-tech. The group offers both financial and human capital, leveraging its network of potential customers, service providers, and future financing sources to support entrepreneurs in building successful businesses.

Atlas Venture L.P. is a private equity and venture capital firm specializing in investments startups, seed, early stage, turnaround, late venture, growth capital and incubation. It seeks to invest in the technology and life sciences sectors with a focus on personalized medicine, medical technologies, therapeutics, biopharmaceutical products, biotechnology, biology, drug discovery technologies, therapeutic platforms, novel biopharmaceutical products, novel therapeutics, novel drug discovery platforms, therapeutic products, innovative biomedical technologies, diagnostics, and medical devices. Within technology, the firm focuses on payments, SMB, consumer-facing innovation, advances in biology, next-generation infrastructure, security, consumer services, small business infrastructure, fintech, emerging web service companies, next-generation media, gaming, and social technologies, enterprise and internet infrastructure, big data and mobile infrastructure, internet related businesses and communications. Within life sciences, it focuses on biopharmaceuticals. It also invest in silicones, consumer discretionary, and internet and direct marketing retail, internet software and services, IT services, security software, memory chips, and broadband telecommunication services. The firm prefers to invest in companies based in the Europe and United States with a focus on New England, Boston, Maine, Connecticut, New Hampshire, Rhode Island, Vermont, California and San Francisco Bay Area. Its initial investment ranges from $0.25 million to $15 million per transaction. The firm prefers to be a lead investor and seeks a board representation in its portfolio companies. Atlas Venture L.P. was founded in 1980 and is headquartered at Cambridge, Massachusetts with an additional office in London, United Kingdom.

LaunchCapital, established in 2008, is a venture capital firm headquartered in New Haven, Connecticut, with additional offices in Boston, New York, and San Francisco. The company invests in early-stage startups, focusing on seed rounds with investments typically ranging from $50,000 to $150,000. LaunchCapital supports entrepreneurs across various sectors, including commerce, marketplace, consumer, media, entertainment, enterprise software, emerging tech, data, finance, healthcare, and medical technology. The firm employs two distinct investment strategies: LaunchCapital Ventures, which follows a traditional equity model for high-growth opportunities, and LaunchCapital Small Business, which offers a blend of equity and debt financing for businesses with linear growth expectations and local or regional reach.

Founded in 1996, MPM Capital is a global investment firm focused on the healthcare and life sciences sectors. It specializes in early-stage investments, typically ranging from $5 million to $50 million, with a primary focus on biotechnology, oncology, medical technology, and specialty pharma. The firm invests globally, with a concentration in North America, Europe, and Asia-Pacific.

Established in 2011 and headquartered in Boston, Gutbrain Ventures is an independent venture capital firm specializing in investments within the enterprise software sector.

Longwood Fund is a Boston-based venture capital firm that creates and invests in science-based companies developing novel solutions for important medical problems. The firm concentrates on healthcare and life sciences, including biotechnology, pharmaceuticals, oncology, and healthtech, supporting ventures from discovery through development with capital and strategic guidance. Established in 2010, Longwood seeks to translate laboratory advances into clinically meaningful products by backing companies built on strong scientific foundations and collaborations with leading research institutions. Through its investments, the firm aims to advance therapies and technologies that address unmet medical needs and improve patient outcomes.

Takeda Ventures is a strategic investment arm of Takeda Pharmaceutical Company Limited, focusing on direct and fund-of-fund investments in healthcare and life sciences sectors. It specializes in seed to mid-stage investments, with a primary focus on therapeutics, regenerative medicines, RNA/DNA modulation, and innovative protein/peptide biologics. The firm invests globally but has a strong presence in the United States, Canada, and Europe.

Samsara BioCapital is a venture capital firm based in Palo Alto, California, that focuses on biotechnology and life sciences companies in the United States. The firm seeks to invest in pharmaceutical and biotechnology ventures, including oncology and other healthcare technologies, with a goal of supporting entrepreneurs in turning ideas into developed therapies. It emphasizes collaboration with ambitious partners and aims to advance biotech innovation and important new therapies by providing capital and advisory support. The organization also operates as a registered investment adviser, offering investment advisory services to guide portfolio companies through growth and development.

Northpond Ventures is a science-driven venture capital firm based in Bethesda, Maryland, with additional offices in San Francisco, California, and Cambridge, Massachusetts. Founded in 2018, the firm concentrates its investments in life sciences, diagnostics, therapeutics, digital health, and related technologies, including AI and machine learning applications in biotech and medical fields, as well as environmental and other emerging technologies. It seeks to back early- and growth-stage companies that advance biomedical research, diagnostics, medical devices, and technology-enabled health solutions. The firm operates as a registered investment adviser and emphasizes building a better tomorrow through science-driven investing. It focuses on strategy, value creation, and supporting companies at the intersection of life sciences and technology, aiming to accelerate innovations that improve health outcomes.

Highland Capital Partners is a Massachusetts-headquartered global venture capital firm that invests in seed, early and growth-stage consumer and enterprise technology companies. It maintains offices in Boston, Silicon Valley and Shanghai and has raised substantial capital and backed more than 225 companies across consumer and enterprise technology, supporting entrepreneurs with a focus on building lasting businesses. The firm also runs mentorship initiatives such as Summer@Highland. Its European presence, Highland Europe, founded in 2012, targets rapidly growing internet, mobile and software companies in Europe and works closely with the firm to pursue primary investments as well as acquisition finance or lead secondary transactions.

LRVHealth is a Boston-based venture capital firm founded in 2000 with additional offices in Marlborough and Amherst, Massachusetts. It concentrates on technology and healthcare investments across seed, early, and growth stages, including Series A and Series B rounds. The firm backs software, software-as-a-service, digital health, healthcare information technology, technology-enabled services, medical devices, diagnostics, and biotechnology, typically investing between $0.5 million and $5 million and often pursuing co-investments. While it seeks opportunities in the United States, it has a regional emphasis on Massachusetts. LRVHealth combines capital with operating experience and industry insight to help portfolio companies grow. It positions itself as an Inside Healthcare network, linking providers, payers, and vendors to identify and adopt innovative solutions addressing the industry's needs. Exits are commonly achieved through trade sales. The firm seeks to support early healthcare and tech-enabled companies by providing strategic guidance, market access, and operational support alongside capital.

Deerfield Management is a New York-based investment firm established in 1994 that focuses on healthcare. It operates across investment, information, and philanthropy to support the healthcare ecosystem. The firm provides private and public investments and offers long-term, structured capital to both public and private healthcare companies. Its portfolio spans life sciences, medical devices, diagnostics, digital health, and health services. As an investment adviser, it seeks opportunities in healthcare products and services and aims to accelerate innovation by combining capital with industry insight.

Venrock is a Palo Alto-based venture capital firm founded in 1969 as the venture capital arm of the Rockefeller family. It concentrates on seed and early-stage investments in technology and healthcare, with interests spanning information technology, life sciences and related sectors in the United States. The firm has supported a broad portfolio of companies, including Apple, Intel, Illumina, DoubleClick, Athenahealth, Gilead Sciences, Nest, SlideShare and Tudou. Venrock emphasizes long-term partnerships with entrepreneurs, combining hands-on venture support with rigorous data analysis to help startups grow into enduring companies.