Top investors in New England

Showing 1-50 of 2365 investors

RA Capital Management

RA Capital Management is a Boston-based investment firm specializing in healthcare, life sciences, and planetary health. It pursues evidence-based, science-led investing through its internal TechAtlas research engine and supports portfolio companies via its Raven healthcare incubator. The firm engages across stages from seed funding to IPOs and follow-on financings, focusing on drugs, medical devices, diagnostics, and other biomedical innovations, with a regional emphasis on the United States and Europe.
Made 113 investments in New England

MassVentures

MassVentures is a Massachusetts-based venture capital firm focused on seed and early-stage investments that advance high-growth startups from concept to commercialization within the state’s innovation economy. Established in 1978 as a quasi-public entity by the Massachusetts Legislature and governed by an independent board, the firm funds ventures in deep tech and related sectors, including quantum computing, clean energy, biotech, artificial intelligence, advanced materials, manufacturing, and robotics. It has backed hundreds of companies and oversees more than $4 billion in follow-on capital, reflecting a durable track record of helping startups attract additional funding and scale. Beyond capital, MassVentures provides non-dilutive grants, commercialization support, mentorship, and strategic guidance through programs such as MV Capital and MV Accelerate, all aimed at building inclusive, connected ventures that leverage Massachusetts’ innovation ecosystem.
Made 184 investments in New England

Alumni Ventures

Alumni Ventures is a venture capital firm that provides accredited investors access to venture-stage and late-stage private market investments. It offers funds, syndicates, investing clubs, and co-investment opportunities with established venture capital firms, and it provides venture investing education through AV Academy along with resources for startup founders.
Made 132 investments in New England

Atlas Venture

Atlas Venture is a Cambridge, Massachusetts-based venture capital firm that specializes in early-stage biotechnology and life sciences companies. Founded in 1980, it focuses on translating breakthrough science into medicines and medical technologies, often employing a seed-led venture creation approach and taking lead investor roles with board representation. The firm operates with dedicated Life Sciences and Technology teams and invests across the United States and Europe, supporting startups through initial funding and early growth. Its portfolio emphasizes biopharmaceuticals, diagnostics, medical devices, and related platforms, reflecting a commitment to advancing innovative healthcare solutions.
Made 207 investments in New England

Morningside Group

Morningside Group is a venture capital firm based in Newton, Massachusetts, founded in 1986 as a family office for the Chan family. It pursues long-term investments in companies with novel science and technology, with active interest in life sciences, digital health, artificial intelligence, materials, and technology sectors. The firm emphasizes ethical business practices and seeks to support the growth of enduring companies. Beyond its investing activities, Morningside supports education, research, and healthcare through charitable commitments to institutions such as the Harvard T.H. Chan School of Public Health, UMass Chan Medical School, and the MIT Morningside Academy for Design.
Made 47 investments in New England

OrbiMed

OrbiMed is a global healthcare investment firm based in New York, founded in 1989. It manages capital across public and private markets, including private equity, venture and growth investments, and private credit, with structured debt and royalty arrangements to support owners of intellectual property and diagnostics. The firm focuses on biopharmaceuticals, life sciences, medical devices, diagnostics, health IT, and healthcare services, investing from startups to multinational companies. With a worldwide team and offices in multiple regions, OrbiMed provides financing and strategic resources to advance therapies and healthcare innovations, aiming to improve patient outcomes across global markets.
Made 98 investments in New England

General Catalyst

General Catalyst is a venture capital firm founded in 2000 and based in Cambridge, Massachusetts, with six global offices. It invests in seed to growth-stage companies across sectors including consumer, enterprise software, fintech, crypto, healthcare, and artificial intelligence, providing capital and strategic guidance to help founders scale. The firm emphasizes mentorship and hands-on support to portfolio companies and aims to accelerate ideas, careers, and ventures. General Catalyst manages a large pool of capital and operates multiple funds, funding minority and majority stakes to help companies achieve scale.
Made 152 investments in New England

Flagship Pioneering

Flagship Pioneering is a Cambridge, Massachusetts-based venture creation company that conceives, builds, and resources first-in-category ventures aimed at transforming human health, biotechnology, and sustainability. Through an integrated approach that combines scientific discovery with entrepreneurial capital, it develops ideas from inception through company creation, supporting portfolio companies such as Moderna, Tessera Therapeutics, Generate Biomedicines, and Quotient Therapeutics. It pursues ambitious programs in biology, medicine, energy, and related fields, frequently collaborating with industry partners and institutions to accelerate discovery and development. The firm emphasizes fearless exploration and an evolutionary methodology to translate scientific breakthroughs into durable companies and impactful solutions for people and the planet.
Made 138 investments in New England

The Invus Group

The Invus Group is a long-standing private equity firm founded in 1985 and based in New York. It partners with entrepreneurs to drive transformative growth across sectors including consumer products and services, technology, life sciences, software, and industrials. The firm emphasizes long-term collaboration, aligns incentives with management, and provides both capital and strategic advisory to help portfolio companies scale internationally. It maintains a global presence with offices in the United States, Europe, and Asia, and pursues flexible investment approaches through evergreen capital structures and co-investment opportunities. The group supports management-led buyouts, growth equity, and select opportunistic investments, aiming to create lasting value rather than short-term gains.
Made 56 investments in New England

Founder Collective

Founder Collective is a seed-stage venture capital firm focused on technology startups. Founded in 2009 by entrepreneurs who have built and exited technology companies, it emphasizes founder-aligned partnerships and capital efficiency, aiming to minimize dilution while supporting portfolio companies from idea to IPO. The firm takes a technology-centric, stage-agnostic approach within seed and early stages and makes investments across the United States and worldwide. Headquartered in Cambridge, Massachusetts, with an office in New York City, Founder Collective leverages the experience of its founders to provide hands-on guidance to portfolio companies. It is built by a collection of successful entrepreneurs and concentrates on backing ambitious teams with potential to reshape industries, prioritizing authenticity, long-term value creation, and close collaboration with founders.
Made 40 investments in New England

ARCH Venture Partners

ARCH Venture Partners is a venture capital firm founded in 1986 and based in Chicago, Illinois, with additional operations in Seattle. The firm focuses on science-based companies, prioritizing life sciences and related technologies, and aims to translate academic and national lab innovations into commercially viable products. ARCH emphasizes a true partnership approach, providing capital alongside strategic guidance, expertise, and a broad professional network to founders. It has supported numerous companies across early to growth stages and is known for backing translational efforts that bring breakthrough discoveries to market, leveraging collaborations with researchers and entrepreneurs to accelerate development of disruptive technologies on a national and international scale.
Made 86 investments in New England

Mission BioCapital

Mission BioCapital is a life science venture capital firm that backs early-stage biotechnology and life sciences companies. With leadership that has a long history of founding and supporting dozens of startups, the firm operates from Cambridge, Massachusetts and San Francisco, California, leveraging a network of researchers and venture capital partners. It provides mentorship, collaboration, and hands-on support from concept through clinical trials, including access to shared laboratory space through its Platinum Program, which offers up to $500,000 in funding, a lab bench, and related services for promising startups. The firm focuses on accelerating scientific solutions and actively participates in portfolio company growth across therapeutic areas, backing companies through multiple funds.
Made 19 investments in New England

Hyperplane Venture Capital

Hyperplane Venture Capital is a Boston-based early-stage venture capital firm that backs technology companies, with a focus on machine intelligence, data, and related technologies. The firm invests in early-stage startups across sectors including artificial intelligence and machine learning, distributed systems, automation, cloud computing, ambient intelligence, robotics, virtual reality, and augmented reality, partnering with exceptional founders who leverage machine intelligence, sensor technology, and cloud computing to solve complex problems and create solutions at the intersection of perception, communication, intelligence, and insight. It was founded in 2015 by Vivjan Myrto, John Murphy, and Brendan Kohler.
Made 62 investments in New England

Spark Capital

Spark Capital is a venture capital firm founded in 2005 and based in San Francisco, with additional offices in Boston and New York. It invests across sectors including consumer, software, fintech, media, internet, education technology, and mobile, backing both early-stage and growth-stage startups. The firm is known for a founder-focused approach that emphasizes flexibility over rigid playbooks, supporting teams as they build and scale innovative products. Its portfolio includes high-profile companies such as Twitter, Discord, Oculus, Warby Parker, Niantic, and Tumblr, reflecting a history of backing companies at pivotal moments in technology and consumer markets.
Made 67 investments in New England

New Enterprise Associates

New Enterprise Associates is a global venture capital firm founded in 1977 and based in Menlo Park, California. It provides capital and operational support to companies across development stages, from seed to IPO, with a focus on technology and healthcare sectors. The firm collaborates with founders to address technical challenges, offering domain expertise to assist product development and market expansion. NEA invests across the United States, Asia and Brazil, and its portfolio includes software, consumer technology, medical devices, life sciences, healthcare information technology, and energy technology companies. With a long track record of helping entrepreneurs achieve growth, NEA emphasizes enduring partnerships and strategic guidance alongside funding to build transformational businesses through multiple stages of a company lifecycle.
Made 134 investments in New England

Accomplice

Accomplice is a seed- and early-stage venture capital firm based in Boston/Cambridge, Massachusetts, backing technology startups in cybersecurity, esports, data analytics, SMB software, emerging hardware, and marketplaces. It operates a community-driven investment model using platforms such as AngelList, Boston Syndicates, Maiden Lane, Spearhead, BOSS, Rev, and TUGG to connect and support founders. Most investments are in Boston, with activity across the United States, Canada, and Europe. The firm originated as the technology group of Atlas Venture and, in 2014, split to form Accomplice, maintaining its focus on early-stage technology companies in New England.
Made 80 investments in New England

Beacon Angels

Beacon Angels is a Boston-based angel investment group founded in 2006 that funds early-stage, high-growth companies in New England. The group typically invests in the range of tens of thousands to a few hundred thousand dollars per company and conducts regular screening of opportunities, with monthly meetings for accredited members and scheduled reviews of new ventures, aiming to grow portfolio value through shared capital and strategic relationships.
Made 21 investments in New England

Third Rock Ventures

Third Rock Ventures is a Boston-based venture capital firm founded in 2007 that invests in life sciences and healthcare companies, including biotechnology, medical devices, diagnostics, therapeutics, and related information technology. The firm targets early-stage and growth opportunities, frequently leads rounds, and takes an active role in portfolio companies, often pursuing strategic collaborations with larger pharmaceutical and biotechnology partners to advance medicines and technologies. Its focus spans oncology, autoimmune diseases, genetic disorders, and other therapeutic areas with the aim of improving patient outcomes through innovative drug development and diagnostics.
Made 66 investments in New England

SOSV

SOSV is a global venture capital firm focused on early-stage deep-tech and cross-border software companies, investing primarily from pre-seed through growth stages. It accelerates product development, regulatory progress, fundraising, and commercial strategy by providing founders access to purpose-built labs, engineering spaces, and a broad physical and virtual infrastructure across multiple locations. The firm's program-driven approach combines selective funding with hands-on support, mentorship, and a wide network of co-investors and partners to help portfolio companies scale. SOSV operates a suite of specialized facilities for deep-tech founders, including incubation programs that connect startups with customers, researchers, and investors, and it emphasizes long-term relationships through ongoing operational and strategic assistance. While active globally, it maintains strong ties to Asia-focused cross-border markets and supports a diverse portfolio spanning bio-tech, hardware, robotics, software, and related fields.
Made 71 investments in New England

Launchpad Venture Group

Launchpad Venture Group is a Boston-based angel investment group that provides funding and strategic guidance to early-stage science and technology startups, primarily in New England. Established in 2001, it operates as a network of individual angel investors and has invested more than $125 million in over 150 startups. The group offers both financial capital and mentorship to help entrepreneurs build long-term value, positioning itself as a leading seed investor in the region across sectors including software, hardware, life sciences, and clean tech. It emphasizes active involvement, advisory support, and building lasting relationships with founders, and it is a member of the Angel Capital Association.
Made 66 investments in New England

Casdin Capital

Casdin Capital is a New York-based venture capital and investment firm focused on the life sciences and healthcare sectors. Founded in 2012 by Eli Casdin, the firm backs companies across genomic research, molecular medicine, precision medicine, diagnostics, synthetic biology, oncology, digital health, and related technologies. It pursues a data-driven, long-term investment approach and seeks to form strong partnerships with portfolio companies to advance scientific innovation and improve patient outcomes. The firm engages with ventures at various stages, from early- to late-stage private companies, emphasizing opportunities at the intersection of biology and technology. Through its activity in life sciences and healthcare, Casdin Capital positions itself as a partner to founders pursuing breakthroughs in genomics, molecular medicine, and AI-enabled healthcare platforms.
Made 55 investments in New England

Connecticut Innovations

Connecticut Innovations is the state's venture capital arm and a governance-backed investment authority headquartered in New Haven. It provides capital and hands-on strategic support to innovative companies across sectors including software, manufacturing, life sciences, clean tech, cybersecurity, data analytics, and e-commerce, with a primary focus on Connecticut-based opportunities. The firm invests across seed, early and growth stages, combining flexible financing with operational guidance, introductions to partners, and network leverage to help portfolio companies scale. It manages a family of funds, including specialized vehicles for artificial intelligence and quantum technology, climate tech, bioscience, and general early-stage and growth investments. Through these funds, Connecticut Innovations aims to accelerate innovation, support job creation, and strengthen the state's technology ecosystem. The organization emphasizes practical support and ongoing partnership, seeking to turn innovative ideas into scalable businesses within Connecticut.
Made 152 investments in New England

Safar Partners

Safar Partners is a venture capital firm based in Cambridge, Massachusetts, investing in seed- to growth-stage technology companies. The firm sources opportunities through close ties with leading universities such as MIT, Harvard, and the University of Rochester and supports portfolio companies across their lifecycle. It focuses on platform technologies in cleantech and advanced materials, artificial intelligence and information technology, robotics, and life sciences including medical devices, primarily backing United States–based startups at early and growth stages.
Made 20 investments in New England

Pillar VC

Pillar VC is a Boston-based venture capital firm focused on seed and early-stage technology companies, including healthcare, biotechnology, artificial intelligence, and scientific discovery. The firm partners with technically driven founders from inception, applying a lab-to-launch playbook to turn research into market-leading companies. Its portfolio includes Abridge, Videa Health, PathAI, Neural Magic, Latent Labs, and Edison, among others, reflecting a commitment to healthcare outcomes, computing and enterprise intelligence, and innovative discovery approaches. Pillar VC backs more than 90 companies, with many originating from university research.
Made 41 investments in New England

Deerfield Management

Deerfield Management is a healthcare-focused investment firm that advances human health by investing in both public and private healthcare companies and by supporting research and development initiatives. The firm targets a broad range of healthcare sectors, including biotechnology, pharmaceuticals, diagnostics, medical devices, digital health, and healthcare services. It seeks to create value through long-term capital deployment, collaboration with strategic partners, and its internal efforts to foster scientific research and drug discovery. In addition to investment activity, Deerfield operates philanthropic initiatives through the Deerfield Foundation that fund education, expanded healthcare access, and health-outcomes improvement.
Made 55 investments in New England

TCG Crossover

TCG Crossover is a science-driven healthcare investment firm focused on advancing disruptive medicines and health technologies. It backs private and public companies led by entrepreneurs developing better treatment options for patients, with activity across the United States and Europe. The firm operates from Palo Alto and New York City and concentrates on healthcare, digital health, and health technology sectors.
Made 16 investments in New England

MPM BioImpact

MPM BioImpact is a venture capital firm focused on building and funding biotechnology companies to transform patient outcomes by developing innovative medicines. Based in Boston, the firm brings more than three decades of experience in translating scientific research into clinical impact and pursues opportunities across the biotechnology, healthcare, and life sciences sectors in the United States. It supports the full drug development process, from discovery through clinical proof of concept and regulatory milestones, with emphasis on areas such as oncology, immunology, neuroscience, and mental health. MPM BioImpact combines deep scientific expertise with strategic leadership to help portfolio companies navigate development challenges and accelerate patient-ready therapies. The firm has backed notable companies across its focus areas, leveraging hands-on guidance and collaboration to translate science into meaningful medical advances.
Made 71 investments in New England

.406 Ventures

.406 Ventures is a Boston-based early-stage venture capital firm that invests in enterprise information technology, cybersecurity, data and cloud, and technology-enabled software and services companies. Founded in 2005, the firm seeks to back B2B and healthcare-related technology sectors, including SaaS, AI, fintech, and digital health, often taking the lead as the first institutional investor in seed and de novo rounds. Investments typically range from $2 million to $5 million initially, with total commitments around $6 million to $10 million per company, and the firm aims to hold board seats as a lead investor. The team emphasizes hands-on involvement, leveraging practical industry experience and networks to help portfolio companies scale. It pursues opportunities across the United States, with emphasis on information technology security and infrastructure and other next-generation software and services.
Made 63 investments in New England

Longwood Fund

Longwood Fund is a venture capital firm based in Boston, Massachusetts, founded in 2010, focused on life sciences and healthcare. It invests in science-based companies that develop novel solutions for medical problems, primarily in biotechnology, pharmaceuticals, and related areas. The firm supports its portfolio from early-stage evaluation through clinical development and commercialization, leveraging a network of industry experts. Longwood highlights a track record of bringing therapies to patients, with more than 20 marketed products and roughly 25 therapies in late-stage development.
Made 24 investments in New England

Northpond Ventures

Northpond Ventures is a science-driven venture capital firm based in Bethesda, Maryland, with offices in San Francisco and Cambridge. It focuses on life sciences, digital health, health tech, and adjacent technology sectors, including diagnostics, therapeutics, artificial intelligence, and machine learning. The firm backs science-based companies across development stages, providing capital and strategic support to enable growth and commercial success.
Made 31 investments in New England

E14 Fund

E14 Fund is a venture capital firm based in Cambridge, Massachusetts, specializing in early-stage investments inspired by technologies developed at MIT. The firm supports seed to Series A rounds across deep technology sectors, helping entrepreneurs translate laboratory research into commercial products. Through a broad network of advisors, including investors, industry experts, and entrepreneurs, E14 Fund assists portfolio companies in scaling, attracting follow-on funding, and navigating market validation. The firm emphasizes diversity and inclusion as drivers of innovation and seeks to connect founders with researchers, mentors, and partners to accelerate development across fields such as biotechnology, smart cities, consumer electronics, and manufacturing.
Made 27 investments in New England

Andreessen Horowitz

Andreessen Horowitz is a venture capital firm based in Menlo Park, California, founded in 2009 by Marc Andreessen and Ben Horowitz. The firm invests in software-enabled businesses across stages, from seed through growth, with a focus on artificial intelligence, healthcare, consumer technologies, fintech, crypto, enterprise software, and infrastructure. Beyond providing capital, the firm offers portfolio companies practical support through a structured ecosystem of technical advisors, executive talent, and industry operators to accelerate growth and scale. It is known for its broad technology focus and aims to build lasting companies from Silicon Valley to global markets.
Made 34 investments in New England

Walnut Venture Associates

Walnut Venture Associates is a Boston-based venture capital firm that backs seed and early-stage information technology companies in the New England region. It typically invests between $250,000 and $1 million and seeks a board seat in portfolio companies to contribute strategic guidance. The firm is led by experienced entrepreneurs and investors who actively support portfolio companies by refining business plans, strengthening management teams, developing financing strategies, and making key strategic connections. Its focus is on technology-driven opportunities in rapidly growing markets, with the goal of helping talented entrepreneurs build lasting value.
Made 49 investments in New England

CRV

CRV is a Palo Alto-based venture capital firm established in 1970 that invests in early-stage technology-driven startups, typically from seed to Series B. The firm adopts a hands-on, value-added approach, working closely with founders to guide product strategy, team building and go-to-market execution as companies scale. CRV funds a broad set of sectors including technology, consumer goods and services, healthcare and life sciences, with North American focus. It operates from offices in Cambridge, Massachusetts and Menlo Park, California, and is recognized as one of the longest-running and most established early-stage firms in the industry. Over its history CRV has backed numerous high-growth, category-defining companies and emphasizes a long-term partnership philosophy that pairs capital with strategic support to help portfolio founders reach significant milestones.
Made 86 investments in New England

PJC

PJC is a Boston-based venture capital firm founded in 2001 that concentrates on early-stage investments across diverse sectors in North America. The firm supports its portfolio companies with industry and financial expertise, a broad network of resources, and a partnership-focused approach that prioritizes strong relationships with entrepreneurs. Its portfolio spans technology and healthcare, including AI, cybersecurity, consumer technology, and enterprise software, with notable exits to major buyers such as Google, Salesforce, Microsoft, Adobe, and Deloitte. PJC emphasizes strategic coaching on smart growth and future financing, leveraging its network to connect founders with experienced resources and potential partners.
Made 39 investments in New England

Boston Seed Capital

Boston Seed Capital is a Boston-headquartered venture capital firm that focuses on seed and early-stage investments in internet-enabled and technology-driven companies across the United States. The firm backs startups in consumer, B2B software as a service, and related services sectors, including information technology, cybersecurity, e-commerce, big data, marketplaces, esports, artificial intelligence and machine learning. It maintains a presence in Wellesley Hills, Massachusetts, and supports founders from pre-seed to scale, leveraging the Boston innovation ecosystem to help accelerate growth.
Made 52 investments in New England

G20 Ventures

G20 Ventures is a Boston-area venture capital firm established in 2013 that backs early-stage enterprise software and technology startups on the East Coast. The firm focuses on Series A rounds, typically $2-5 million, and reserves capital for earlier-stage deals to stay with companies through growth. It emphasizes technology risk over market risk and seeks teams with a technologist and a business leader who understand the buyer, with a product in market and early customer validation. G20 Ventures advocates a collaborative, community-driven approach, leveraging its network to help portfolio companies scale efficiently while minimizing dilution.
Made 17 investments in New England

Newpath Partners

Newpath Partners is a Boston-based venture capital firm that makes multi-stage investments in life sciences and healthcare companies. Founded in 2018, the firm emphasizes rigorous scientific evaluation and strategic partnerships built on trust. It backs companies with strong science and clear milestones, supporting founders through development to commercial launch. Based in Boston, Massachusetts, the firm seeks to help portfolio companies advance therapies, diagnostics, and healthcare technologies.
Made 8 investments in New England

Samsara BioCapital

Samsara BioCapital is a venture capital firm based in Palo Alto, California, founded in 2016. The firm focuses on the healthcare sector, investing in biotechnology companies across the United States and serving as an investment adviser to support the development of transformative therapeutics. By combining scientists, clinicians, drug developers, and business leaders with extensive experience, Samsara BioCapital aims to accelerate the next generation of therapies through collaborative partnerships and strategic capital. The firm operates as a principal investor and provides guidance to entrepreneurs seeking to turn their ideas into successful biotech ventures.
Made 28 investments in New England

Khosla Ventures

Khosla Ventures is a California-based venture capital firm founded in 2004 that backs technology-driven startups across multiple sectors, including artificial intelligence, healthcare, sustainability, digital health, and consumer technology. The firm provides capital and strategic guidance to companies at early and growth stages, with an emphasis on disruptive technologies and world-changing businesses. It operates a range of funds, including seed and later-stage vehicles, and maintains a broad investment thesis that covers AI, climate tech, energy efficiency, and other high-potential areas, primarily focused in the United States. The firm is known for working closely with entrepreneurs to build long-lasting companies.
Made 41 investments in New England

Tiger Global Management

Tiger Global Management is a global investment firm founded in 2001 by Charles (Chase) Coleman. It invests in both private and public markets worldwide, with a focus on technology, internet, consumer, and financial services companies. The firm employs strategies across public equities, including growth and long/short approaches, and private investments across early to late stages, seeking high-quality growth opportunities throughout the lifecycle of portfolio companies. Its activities span globally, aiming to back innovative companies across diverse regions and industries. As a registered investment adviser in the United States, Tiger Global conducts its business through its own platform, dedicating capital to long-term partnerships with high-potential companies.
Made 32 investments in New England

EcoR1 Capital

EcoR1 Capital is a venture capital firm based in San Francisco that invests in early-stage biotechnology companies developing innovative therapeutics. It applies a scientific approach, leveraging advances in molecular biology to identify promising ventures and support their pursuit of new medicines. The firm emphasizes partnering with entrepreneurs dedicated to therapeutic innovation and provides strategic and scientific guidance to help translate breakthrough discoveries into treatments for patients.
Made 35 investments in New England

One Way Ventures

One Way Ventures is a venture capital firm founded in 2017 and headquartered in Boston, with additional offices in Montreal and Mountain View. It specializes in seed-stage investments in technology startups, with a focus on immigrant founders and global companies. The firm targets software, fintech, and digital sector startups in the United States and Canada, seeking to back entrepreneurs building scalable businesses and expanding internationally, including a U.S. presence. It is active in the New England venture community and aims to promote equal opportunity for founders regardless of origin.
Made 21 investments in New England

Catalyst Health Ventures

Catalyst Health Ventures is a Boston-based venture capital firm founded in 2008 that concentrates on health care and life sciences, with emphasis on medical technologies, including therapeutic devices, diagnostics, drug delivery, digital health, and other healthcare innovations. It targets early-stage opportunities and provides capital in subsequent rounds, combining financial backing with strategic guidance, industry expertise, and collaborative support to management and syndicate partners. The investment thesis prioritizes technology-driven solutions with clear regulatory pathways and scalable business models that address major global unmet clinical needs in areas such as oncology, cardiovascular disease, obesity, and women's health. By backing solutions built on engineering and development foundations like medical devices, diagnostic tools, and consumer health technologies, Catalyst Health Ventures aims to reduce treatment costs and improve patient outcomes through capital-efficient innovation and practical commercialization strategies.
Made 22 investments in New England

Dementia Discovery Fund

Dementia Discovery Fund is a venture capital organization focused on dementia therapeutics and enabling technologies. Managed by SV Health Investors, it operates as a family of specialized funds that invests exclusively in companies developing novel dementia treatments or the tools that advance them. With offices in London and Boston, it leverages a global network of venture partners, scientists, and strategic collaborators to identify opportunities, form new biotech ventures, and support early-stage development. The organization pursues a dual mandate of delivering measurable patient impact and generating financial returns, supported by a diverse set of investors including pharmaceutical companies, healthcare organizations, and philanthropic partners, all aimed at accelerating progress toward effective therapies for Alzheimer’s disease and related conditions.
Made 13 investments in New England

Bantam Group

Bantam Group is an advisory and investment firm based in Westwood, Massachusetts, founded in 1993 by Joe Caruso. It works with entrepreneurs across industries, providing strategic guidance, mentorship, and advocacy, and acts as a catalyst for growth. The firm oversees a portfolio of affiliated companies and concentrates on the technology sector, offering support in funding, strategy, and leadership through its network and objective advice. Notable involvements include startups such as ZipCar, HubSpot, and Coffee Connection, which illustrate its hands-on approach to helping entrepreneurs realize their business goals.
Made 59 investments in New England

Prelude Ventures

Prelude Ventures is a San Francisco-based venture capital firm that backs early-stage startups focused on mitigating climate change. Founded in 2013, the firm targets investments across built environment, carbon management, compute, energy, food and agriculture, manufacturing and industrials, and mobility, seeking to support category-defining companies and scalable climate solutions.
Made 24 investments in New England

Boxer Capital

Boxer Capital is a biotech investment firm and the corporate venture capital arm of Tavistock Group, based in San Diego, California. The firm invests in biotechnology and precision medicine companies across private and public markets, spanning the drug development lifecycle from early discovery to late-stage development and commercialization, with a focus on oncology and novel targets. It emphasizes scientific expertise and a disciplined, research-driven due diligence process that includes clinical, regulatory, and commercial assessment. Boxer Capital maintains independent investment decisions and has partnered with portfolio companies such as Mirati Therapeutics to support growth. The firm seeks opportunities in specialized medicine, precision oncology, and related life sciences sectors.
Made 22 investments in New England

Borealis Ventures

Borealis Ventures is a venture capital firm founded in 2002 and based in Hanover, New Hampshire, with an additional office in Portsmouth. It backs early-stage and growth companies across life sciences, healthcare and technology, including digital health, information technology, application software, internet and mobile services, and design and engineering software. The firm often acts as lead investor but also co-invests with others and seeks a board seat in portfolio companies. It maintains a national investment footprint with a focus on New England and the Dartmouth College network. Borealis emphasizes funding from seed through Series A and beyond, supporting scalable companies in its target sectors.
Made 21 investments in New England

Sequoia Capital

Sequoia Capital is a venture capital firm founded in 1972 and based in Menlo Park, California. It provides capital and strategic guidance to early-stage and growth-stage technology companies worldwide, investing across information technology, software, internet, hardware, healthcare, financial services, and related sectors. The firm emphasizes long-term partnerships, typically engaging with portfolio companies from idea or formation through scale, and assisting with product development, market expansion, and organizational building. Sequoia seeks to back ambitious teams and collaborates closely with leadership to navigate growth, governance, and go-to-market strategy, with a global footprint that spans the United States and key international markets.
Made 30 investments in New England