The Engine

BlueShift is a climate technology company that specializes in electrochemical processes. It develops systems to capture carbon dioxide directly from the ocean and convert industrial waste into valuable minerals, such as nickel and carbonates. This process not only provides sustainable sources for these materials but also significantly reduces atmospheric carbon, contributing to climate change mitigation.

VEIR is a company focused on innovative electricity transmission solutions using high-temperature superconductors. It has developed a unique passive evaporative cryogenic cooling technology that significantly enhances cooling efficiency, delivering twenty times the cooling power per kilogram of nitrogen flow compared to traditional mechanical methods. By utilizing commercial superconducting tape, VEIR's technology enables power delivery at transmission levels without resistive losses. This advancement allows clients to streamline permitting processes and supports the economical establishment of electric transmission lines across distribution-scale infrastructure.

Osmoses is a company focused on decarbonizing gas separations to significantly reduce carbon emissions, aiming to eliminate one gigaton of carbon emissions annually. It operates a clean membrane technology system designed to lower energy consumption and carbon emissions in industrial processes. The company's molecular filters are specifically engineered for exceptional size selectivity, allowing them to purify hydrogen and natural gas effectively while also enabling large-scale carbon capture. By transforming chemical separations, Osmoses helps industrial clients reduce costs and product loss, ultimately generating value and contributing to climate change mitigation efforts.

Vaxess Technologies, Inc. is a biotechnology company based in Boston, Massachusetts, founded in 2011. The company specializes in the development and commercialization of silk biomaterial technologies, particularly the MIMIX microneedle platform, which facilitates transdermal delivery of vaccines and therapeutics. This innovative sustained release patch technology enhances vaccine administration by simulating a natural infection, promoting a robust and prolonged immune response, thereby improving vaccine effectiveness. Additionally, Vaxess’s MATRIX formulation and drying platform creates thermostable vaccines, therapeutics, and diagnostic products that do not require refrigeration, making them suitable for distribution in low-resource settings. Through these advanced solutions, Vaxess aims to improve patient outcomes in oncology care and infectious diseases while reducing treatment burdens for healthcare practitioners.

Amide specializes in the synthesis of complex peptides that are challenging to produce through conventional methods. By bridging the gap between traditional solid phase peptide synthesis and biological expression, the company utilizes unnatural amino acids and artificial protein backbones to expand the possibilities within peptide synthesis. Amide's Automated Fast Flow Peptide Synthesizer enhances the synthesis process by employing flow chemistry, which significantly improves efficiency and outcomes. This technology allows for the generation of highly reactive intermediates in situ and optimizes heat and mass transfer, resulting in superior synthetic results compared to traditional methods. Through these advancements, Amide aims to facilitate the development of next-generation protein therapeutics, ultimately enhancing patient health.

Celestial AI is a machine learning accelerator focused on developing an optical interconnect technology platform designed for data centers and AI applications. By leveraging photonics, mixed-signal ASICs, and advanced packaging, the company aims to enhance computing performance sustainably. Its Photonic Fabric technology serves as the foundation for optically scalable and disaggregated data center computing and memory, facilitating significant advancements in AI. Celestial AI’s solutions enable clients to deliver improved hardware and software alternatives for deep learning and machine learning, ultimately driving profitable and sustainable business models.

Hyfé is a feedstock processing company focused on transforming food waste into valuable chemicals and materials, thereby promoting sustainability in various industries. By utilizing fungal fermentation, Hyfé upcycles waste generated during food manufacturing, enabling the production of cost-competitive essential goods. This innovative approach not only maximizes profits for food manufacturers but also contributes to reducing the carbon footprint of the food industry. Through its commitment to creating sustainable chemicals, materials, fuels, and foods, Hyfé aims to unlock the full value of every crop while providing alternatives to petroleum-based products.

VEIR is a company focused on innovative electricity transmission solutions using high-temperature superconductors. It has developed a unique passive evaporative cryogenic cooling technology that significantly enhances cooling efficiency, delivering twenty times the cooling power per kilogram of nitrogen flow compared to traditional mechanical methods. By utilizing commercial superconducting tape, VEIR's technology enables power delivery at transmission levels without resistive losses. This advancement allows clients to streamline permitting processes and supports the economical establishment of electric transmission lines across distribution-scale infrastructure.

Droplet Biosciences is a molecular diagnostics company focused on enhancing cancer care through innovative liquid biopsy techniques that utilize lymphatic fluid. By offering earlier and more accurate cancer diagnoses, the company aims to improve patient outcomes and support healthcare professionals in making informed post-operative treatment decisions. With its non-invasive approach, Droplet Biosciences seeks to transform the landscape of cancer diagnostics, providing sensitive and reliable testing that can lead to better management of the disease.

Sublime Systems is a company focused on decarbonizing cement production through innovative technology that simultaneously generates green hydrogen and reduces carbon emissions. Their approach employs an electrochemical method powered by clean, renewable energy, effectively eliminating CO2 emissions while preserving the essential characteristics and chemistry of the cement. This technology allows builders and consumers to actively participate in the transition towards a sustainable and renewable future, aligning with global efforts to mitigate climate change.

Vaxess Technologies, Inc. is a biotechnology company based in Boston, Massachusetts, founded in 2011. The company specializes in the development and commercialization of silk biomaterial technologies, particularly the MIMIX microneedle platform, which facilitates transdermal delivery of vaccines and therapeutics. This innovative sustained release patch technology enhances vaccine administration by simulating a natural infection, promoting a robust and prolonged immune response, thereby improving vaccine effectiveness. Additionally, Vaxess’s MATRIX formulation and drying platform creates thermostable vaccines, therapeutics, and diagnostic products that do not require refrigeration, making them suitable for distribution in low-resource settings. Through these advanced solutions, Vaxess aims to improve patient outcomes in oncology care and infectious diseases while reducing treatment burdens for healthcare practitioners.

Syzygy Plasmonics, Inc. is a Houston-based company that specializes in the design, development, and manufacturing of photocatalytic reactor systems for industrial chemical reactions. Founded in 2017, the company focuses on creating reactors that facilitate the generation of fuel cell quality hydrogen from ammonia, specifically for small-to-medium-scale applications. These advanced reactors operate at significantly lower temperatures than traditional chemical reactors, allowing for reduced maintenance costs and the ability to quickly start or stop production. By utilizing light as an energy source, Syzygy Plasmonics enables the integration of renewable electricity into chemical manufacturing, contributing to the decarbonization of various industries and supporting the on-site production of ultra-low-cost hydrogen gas for fuel cell vehicles.

Vaxess Technologies, Inc. is a biotechnology company based in Boston, Massachusetts, founded in 2011. The company specializes in the development and commercialization of silk biomaterial technologies, particularly the MIMIX microneedle platform, which facilitates transdermal delivery of vaccines and therapeutics. This innovative sustained release patch technology enhances vaccine administration by simulating a natural infection, promoting a robust and prolonged immune response, thereby improving vaccine effectiveness. Additionally, Vaxess’s MATRIX formulation and drying platform creates thermostable vaccines, therapeutics, and diagnostic products that do not require refrigeration, making them suitable for distribution in low-resource settings. Through these advanced solutions, Vaxess aims to improve patient outcomes in oncology care and infectious diseases while reducing treatment burdens for healthcare practitioners.

Axoft is a developer of innovative implantable electronics that enhance communication between the brain and external devices. The company specializes in bioinspired, ultra-flexible brain implants made from a plastic mesh that mimics the mechanical properties of brain tissue, allowing for improved integration and comfort. This technology enables the incorporation of multiple sensors into a single implant, making it scalable and adaptable for various medical applications. Axoft's advancements aim to transform treatment options for neurodegenerative conditions, such as Parkinson's disease, ultimately improving clinical outcomes and the overall health experience for patients.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

Mantel is a company focused on advancing carbon capture technology aimed at reducing carbon dioxide emissions and achieving net-negative emissions. Its innovative system is designed to operate within boilers, kilns, and furnaces, utilizing biomass waste and residue to facilitate significant carbon removal. By leveraging liquid-phase chemistry, Mantel's technology targets key industrial sectors such as industrial heat, steel, and chemicals. This approach not only mitigates sustainability concerns but also enables clients to reduce the costs associated with carbon capture, emissions, and storage, ultimately contributing to broader environmental goals.

Sync Computing Corp., established in 2019 and headquartered in Cambridge, Massachusetts, specializes in manufacturing Optimization Processing Units (OPUs). These units are designed to tackle combinatorial optimization problems across various sectors such as telecom, pharma, finance, logistics, and machine learning-dependent industries. Sync Computing's OPU is essentially an algorithm in hardware form, enabling organizations to efficiently solve complex optimization challenges.

Atlantic Quantum is a company focused on the development of scalable quantum computers aimed at addressing complex computational challenges. Founded in 2022, the company emphasizes the importance of fault-tolerant quantum hardware as a critical factor in advancing the field of quantum computing. By creating innovative computer hardware solutions, Atlantic Quantum seeks to empower engineers and researchers to achieve significant breakthroughs in computation.

Foundation Alloy is a manufacturer specializing in the production of metal parts that focus on optimizing the manufacturing process for environmental sustainability and cost-effectiveness. The company utilizes advanced materials technology to design novel alloys specifically tailored for additive manufacturing. By integrating proprietary alloy design, advanced manufacturing techniques, and automation, Foundation Alloy enhances the performance and production efficiency of industrial applications compared to traditional materials and processes. This innovative approach enables front-line engineers to improve the overall manufacturing experience while reducing environmental impact.

Hyfé is a feedstock processing company focused on transforming food waste into valuable chemicals and materials, thereby promoting sustainability in various industries. By utilizing fungal fermentation, Hyfé upcycles waste generated during food manufacturing, enabling the production of cost-competitive essential goods. This innovative approach not only maximizes profits for food manufacturers but also contributes to reducing the carbon footprint of the food industry. Through its commitment to creating sustainable chemicals, materials, fuels, and foods, Hyfé aims to unlock the full value of every crop while providing alternatives to petroleum-based products.

Seaspire Skincare specializes in the development of multifunctional colorants and active ingredients, drawing inspiration from the ocean's biodiversity. The company focuses on addressing chronic and cosmetic skin and hair conditions while aiming to replace harmful components commonly found in sunscreens. A key innovation is the biomolecule Xanthochrome, which provides protection against a wider spectrum of ultraviolet radiation compared to existing UV filters. This product not only supports preventative skincare but also promotes sustainability within the skincare industry by minimizing harmful effects on both human health and marine ecosystems. Seaspire Skincare is committed to delivering safer, less toxic alternatives for consumers and the environment.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Quaise is an energy company based in Cambridge, Massachusetts, focused on developing innovative millimeter-wave drilling systems to access deep geothermal energy resources worldwide. Founded in 2018, Quaise aims to overcome the geographic limitations that currently restrict geothermal energy utilization. The company's technology repurposes existing fossil-fuel industrial assets by drilling onsite at operational power plants, leveraging existing infrastructure and workforce to facilitate a smoother transition to clean energy. By enabling mining companies to harness this geothermal potential, Quaise aspires to generate terawatts of clean power that can compete with fossil fuels while producing zero carbon emissions.

Celestial AI is a prominent artificial intelligence company that provides an advanced platform for users to efficiently create images, text, and presentations. Utilizing cutting-edge computer vision algorithms and natural language processing, the platform produces high-quality visual and textual content. Its intuitive design, combined with innovative features, facilitates easy content creation. Moreover, Celestial AI emphasizes intelligent data integration and prioritizes security, ensuring that users achieve impressive and reliable results.

Resonant Link LLC, founded in 2017 and based in Shelburne, Vermont, specializes in manufacturing and developing advanced wireless charging solutions. The company utilizes innovative coil technology, particularly its multi-layer self-resonant structure (MSRS), to deliver fast, efficient, and reliable wireless power. Resonant Link's products cater to a wide range of industries, including robotics, drones, electric vehicles, industrial trucks, and medical devices. By eliminating expensive components in conventional wireless chargers, the company enhances performance while reducing size, weight, and cost, thereby increasing the range and power of wireless charging solutions.

Sync Computing Corp., established in 2019 and headquartered in Cambridge, Massachusetts, specializes in manufacturing Optimization Processing Units (OPUs). These units are designed to tackle combinatorial optimization problems across various sectors such as telecom, pharma, finance, logistics, and machine learning-dependent industries. Sync Computing's OPU is essentially an algorithm in hardware form, enabling organizations to efficiently solve complex optimization challenges.

Cellino is focused on developing a scalable, automated biomanufacturing system aimed at producing personalized cell therapies. The company's innovative platform leverages AI-guided laser editing to generate autologous induced pluripotent stem cells (iPSCs) efficiently and at scale. By utilizing image-guided machine learning, single-cell laser processing, and robotics, Cellino seeks to make advanced, potentially curative treatments accessible for a range of chronic degenerative diseases, including vision loss and Parkinson's disease. The company's mission is to transform healthcare by enabling personalized therapies that can significantly improve patient outcomes and overall health.

Commonwealth Fusion Systems LLC is an energy research company based in Cambridge, Massachusetts, focused on developing fusion energy technology to address climate change. Established in 2017 as a spin-out from the Massachusetts Institute of Technology, the company utilizes rare-earth barium copper oxide superconductor technology to enhance fusion energy production. By integrating proven physics with advanced superconducting magnet technology, Commonwealth Fusion Systems aims to accelerate the commercialization of fusion energy. The company's efforts are directed toward designing and constructing fusion machines that promise limitless and clean energy, positioning them as a key player in the transition to renewable energy sources. Through collaboration with MIT's Plasma Science and Fusion Center, the company leverages decades of government-funded research to innovate within the private sector, ultimately contributing to the global pursuit of sustainable energy solutions.

Osmoses is a company focused on decarbonizing gas separations to significantly reduce carbon emissions, aiming to eliminate one gigaton of carbon emissions annually. It operates a clean membrane technology system designed to lower energy consumption and carbon emissions in industrial processes. The company's molecular filters are specifically engineered for exceptional size selectivity, allowing them to purify hydrogen and natural gas effectively while also enabling large-scale carbon capture. By transforming chemical separations, Osmoses helps industrial clients reduce costs and product loss, ultimately generating value and contributing to climate change mitigation efforts.

Hedron is a company focused on developing a modular and scalable network of data relay satellites designed to enhance data connectivity in space. Their satellite network utilizes a hybrid RF-optical communication system to facilitate real-time communication between Earth and low-earth-orbiting satellites. By offering advanced data connectivity solutions, Hedron aims to address critical global challenges such as food and water security, climate change monitoring, and disaster mitigation. The company's imaging satellites generate valuable data that provide insights to optimize the global economy and improve understanding of the planet. Through its innovative approach, Hedron is positioned to create new opportunities for advancements in space technology and data utilization.

Via Separations, Inc. is a company that specializes in developing membrane-based products for the separation of industrial liquids, aimed at enhancing efficiency in challenging industrial environments. Founded in 2016 and based in Somerville, Massachusetts, the company focuses on industrial decarbonization through innovative chemistries that significantly reduce energy consumption in manufacturing processes. Via's technology allows facilities to cut energy usage by 90% during chemical separation, replacing traditional heat-based methods with a highly selective and robust membrane filtration system. This advancement not only helps to minimize the environmental impact of industrial processes, but it also creates additional revenue opportunities for customers. Currently, Via is conducting pilot trials at pulp and paper facilities with the goal of eliminating 100 million metric tons of CO2 emissions by 2050. The company has successfully scaled its technology and demonstrated working prototypes at a commercial level, having emerged from MIT's Department of Material Science & Engineering.

Kytopen, established in 2017 and based in Cambridge, Massachusetts, specializes in the development of a cell therapy platform. This platform facilitates the non-viral delivery of molecules into challenging-to-transfect immune cells, making the process easier, faster, and more cost-effective. The company's proprietary Flowfect™ technology combines microfluidics and automation, enabling researchers to explore new biological discoveries and develop more affordable cell and gene therapies.

Lilac Solutions, Inc. is a mining technology company based in Oakland, California, specializing in lithium extraction technology. Founded in 2015, the company develops innovative solutions that utilize ion-exchange theory to absorb lithium from brine deposits. This technology includes ion exchange beads and continuous brine processing systems, which enable lithium producers to enhance project development, increase lithium recovery, and optimize operations. Lilac Solutions aims to support industries such as electric vehicles and renewable energy storage by providing methods that reduce both costs and environmental impact associated with lithium production.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

Emvolon is a technology company focused on creating a platform for distributed chemical production that utilizes wasted resources. The company's innovative approach involves converting wasted natural gas from flare sites into usable chemicals, which can serve a variety of industrial applications or be transformed into carbon-negative fuels. Emvolon reimagines traditional diesel engines as miniature chemical reactors, allowing for efficient and effective production without the need for large refineries or chemical plants. This process facilitates the establishment of economically viable small-scale production facilities by leveraging the advantages of mass production alongside economies of scale, ultimately providing communities with the essential raw materials they require.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Syzygy Plasmonics, Inc. is a Houston-based company that specializes in the design, development, and manufacturing of photocatalytic reactor systems for industrial chemical reactions. Founded in 2017, the company focuses on creating reactors that facilitate the generation of fuel cell quality hydrogen from ammonia, specifically for small-to-medium-scale applications. These advanced reactors operate at significantly lower temperatures than traditional chemical reactors, allowing for reduced maintenance costs and the ability to quickly start or stop production. By utilizing light as an energy source, Syzygy Plasmonics enables the integration of renewable electricity into chemical manufacturing, contributing to the decarbonization of various industries and supporting the on-site production of ultra-low-cost hydrogen gas for fuel cell vehicles.

VEIR is a company focused on innovative electricity transmission solutions using high-temperature superconductors. It has developed a unique passive evaporative cryogenic cooling technology that significantly enhances cooling efficiency, delivering twenty times the cooling power per kilogram of nitrogen flow compared to traditional mechanical methods. By utilizing commercial superconducting tape, VEIR's technology enables power delivery at transmission levels without resistive losses. This advancement allows clients to streamline permitting processes and supports the economical establishment of electric transmission lines across distribution-scale infrastructure.

Cellino is focused on developing a scalable, automated biomanufacturing system aimed at producing personalized cell therapies. The company's innovative platform leverages AI-guided laser editing to generate autologous induced pluripotent stem cells (iPSCs) efficiently and at scale. By utilizing image-guided machine learning, single-cell laser processing, and robotics, Cellino seeks to make advanced, potentially curative treatments accessible for a range of chronic degenerative diseases, including vision loss and Parkinson's disease. The company's mission is to transform healthcare by enabling personalized therapies that can significantly improve patient outcomes and overall health.

Celestial AI is a prominent artificial intelligence company that provides an advanced platform for users to efficiently create images, text, and presentations. Utilizing cutting-edge computer vision algorithms and natural language processing, the platform produces high-quality visual and textual content. Its intuitive design, combined with innovative features, facilitates easy content creation. Moreover, Celestial AI emphasizes intelligent data integration and prioritizes security, ensuring that users achieve impressive and reliable results.

Boston Metal, founded in 2012 as a spinout from MIT, is a metallurgy company headquartered in Woburn, MA. It specializes in developing technology to reduce the carbon footprint of steel production through its Molten Oxide Electrolysis (MOE) process. This industrial-scale solution enables efficient, lower-cost, and greener production of various metals and alloys from diverse feedstocks. Boston Metal has significantly scaled its technology and produced substantial quantities of metal since its inception.

The Routing Company, established in 2018 and headquartered in Cambridge, Massachusetts, specializes in developing advanced driver and rider applications for real-time shared ride routing. The company's core business involves providing private fleet management solutions, demand-responsive transit systems, analytics dashboards, and transit & paratransit services. Its flagship product, the Pingo™ app, facilitates on-demand or advance trip requests across various modes of operation, including on-demand, flex, fixed, and paratransit. The Routing Company partners with cities worldwide to enhance public transit efficiency, equity, accessibility, cost-effectiveness, and sustainability through its proprietary artificial intelligence-driven platform.

Zapata Computing, Inc. is a quantum software company that specializes in developing innovative computing solutions tailored for industrial and commercial applications. Founded in 2017 and headquartered in Boston, Massachusetts, with an additional office in Toronto, the company emerged from Harvard University and is driven by a team of scientists, including Alán Aspuru-Guzik. Zapata offers Orquestra, a software platform that enables the composition of quantum workflows using a YAML-compatible language, facilitating tasks across both quantum and classical hardware. Its solutions are hardware-agnostic and cater to various sectors, including finance, healthcare, pharmaceuticals, transportation, logistics, energy, and more. Equipped to address complex challenges, Zapata Computing focuses on simulation, optimization, and machine learning, helping enterprise organizations harness the power of quantum technology to enhance their operations.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

WoHo is a company based in Cambridge, Massachusetts, founded in 2020, that focuses on innovative construction systems and technology. It aims to revolutionize the building process by assembling teams, networks, and systems to create both low and high-rise structures with exceptional quality, precision, and efficiency. WoHo's platform integrates architecture, engineering, and construction, providing clients with sustainable and cost-effective solutions for various living and working spaces. By streamlining these processes, WoHo offers competitive alternatives in the construction industry, enhancing the overall efficiency of project delivery.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Quaise is an energy company based in Cambridge, Massachusetts, focused on developing innovative millimeter-wave drilling systems to access deep geothermal energy resources worldwide. Founded in 2018, Quaise aims to overcome the geographic limitations that currently restrict geothermal energy utilization. The company's technology repurposes existing fossil-fuel industrial assets by drilling onsite at operational power plants, leveraging existing infrastructure and workforce to facilitate a smoother transition to clean energy. By enabling mining companies to harness this geothermal potential, Quaise aspires to generate terawatts of clean power that can compete with fossil fuels while producing zero carbon emissions.

Commonwealth Fusion Systems LLC is an energy research company based in Cambridge, Massachusetts, focused on developing fusion energy technology to address climate change. Established in 2017 as a spin-out from the Massachusetts Institute of Technology, the company utilizes rare-earth barium copper oxide superconductor technology to enhance fusion energy production. By integrating proven physics with advanced superconducting magnet technology, Commonwealth Fusion Systems aims to accelerate the commercialization of fusion energy. The company's efforts are directed toward designing and constructing fusion machines that promise limitless and clean energy, positioning them as a key player in the transition to renewable energy sources. Through collaboration with MIT's Plasma Science and Fusion Center, the company leverages decades of government-funded research to innovate within the private sector, ultimately contributing to the global pursuit of sustainable energy solutions.

Biobot Analytics, Inc. is a wastewater epidemiology company based in Cambridge, Massachusetts, founded in 2017. It specializes in transforming wastewater infrastructure into public health observatories through innovative technology that analyzes sewage for health-related data. By deploying proprietary sampling devices and spatial analytics, Biobot measures various health threats, including infectious diseases, antibiotic resistance, and drug consumption patterns. The company's Opioid Consumption Monitoring Program specifically estimates opioid use in urban areas by analyzing wastewater. This approach generates anonymized public health data that is independent of traditional hospital reporting systems, allowing for rapid adaptability to emerging public health threats. Biobot Analytics offers its insights as a service, providing government officials with actionable data to prioritize interventions and address public health challenges effectively.

Rise Robotics, based in Somerville, Massachusetts, specializes in designing and manufacturing innovative robotic components inspired by biological systems. Founded in 2011, the company aims to revolutionize the robotics industry by creating powerful wearable ExoSUITS. Their flagship product, the Cyclone Muscle, is a lightweight electric linear actuator that effectively transforms rotary motor motion into linear muscle-like actuation, addressing the critical balance between force, speed, and control. Additionally, Rise Robotics has developed the Bacon Robotic Air Compressor, which enhances traditional handheld air compressors through its unique Cyclone Linear Drive technology. This breakthrough innovation positions Rise Robotics at the forefront of advancing mobile robotic applications.

Lilac Solutions, Inc. is a mining technology company based in Oakland, California, specializing in lithium extraction technology. Founded in 2015, the company develops innovative solutions that utilize ion-exchange theory to absorb lithium from brine deposits. This technology includes ion exchange beads and continuous brine processing systems, which enable lithium producers to enhance project development, increase lithium recovery, and optimize operations. Lilac Solutions aims to support industries such as electric vehicles and renewable energy storage by providing methods that reduce both costs and environmental impact associated with lithium production.

Seaspire Skincare specializes in the development of multifunctional colorants and active ingredients, drawing inspiration from the ocean's biodiversity. The company focuses on addressing chronic and cosmetic skin and hair conditions while aiming to replace harmful components commonly found in sunscreens. A key innovation is the biomolecule Xanthochrome, which provides protection against a wider spectrum of ultraviolet radiation compared to existing UV filters. This product not only supports preventative skincare but also promotes sustainability within the skincare industry by minimizing harmful effects on both human health and marine ecosystems. Seaspire Skincare is committed to delivering safer, less toxic alternatives for consumers and the environment.

Sync Computing Corp., established in 2019 and headquartered in Cambridge, Massachusetts, specializes in manufacturing Optimization Processing Units (OPUs). These units are designed to tackle combinatorial optimization problems across various sectors such as telecom, pharma, finance, logistics, and machine learning-dependent industries. Sync Computing's OPU is essentially an algorithm in hardware form, enabling organizations to efficiently solve complex optimization challenges.

ISEE, Inc. is an autonomous driving technology company based in Cambridge, Massachusetts, established in 2016. The company specializes in developing artificial intelligence-based software and hardware solutions for self-driving vehicles, particularly focusing on automating logistics and supply chain operations. ISEE's innovative platform utilizes advanced AI to understand uncertainty, predict human behavior, and assess risk and efficiency, thereby enhancing the operational capabilities of autonomous machines. Its autonomous yard trucks are designed to improve safety, cost-effectiveness, and driving performance for major clients, including prominent companies in the retail and shipping industries. By leveraging its proprietary technology, ISEE aims to modernize supply chain logistics and contribute to seamless integration of autonomous systems in real-world applications.

E25Bio Inc. is a biotechnology company based in Cambridge, Massachusetts, founded in 2018, that focuses on developing rapid diagnostic tests for epidemic fever viruses. The company designs paper-based diagnostic systems and kits that facilitate the detection of viruses such as dengue, chikungunya, and Zika. E25Bio's innovative platform enables multiplexed testing that quickly identifies viral antigens during infections, allowing for real-time data reporting through a mobile application. This capability supports epidemiologic predictions and disease mapping, empowering governments and health organizations to respond effectively to outbreaks and manage public health crises. Through its commitment to fast, mobile testing solutions, E25Bio aims to prevent severe health outcomes associated with viral epidemics.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

Syzygy Plasmonics, Inc. is a Houston-based company that specializes in the design, development, and manufacturing of photocatalytic reactor systems for industrial chemical reactions. Founded in 2017, the company focuses on creating reactors that facilitate the generation of fuel cell quality hydrogen from ammonia, specifically for small-to-medium-scale applications. These advanced reactors operate at significantly lower temperatures than traditional chemical reactors, allowing for reduced maintenance costs and the ability to quickly start or stop production. By utilizing light as an energy source, Syzygy Plasmonics enables the integration of renewable electricity into chemical manufacturing, contributing to the decarbonization of various industries and supporting the on-site production of ultra-low-cost hydrogen gas for fuel cell vehicles.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Lucy Therapeutics is a biotechnology company focused on developing innovative treatments for neurological diseases by targeting mitochondrial dysfunction. The company employs a unique approach to drug discovery, concentrating on drugging targets linked to the early stages of disease pathogenesis. This methodology not only addresses specific neurological conditions but also has the potential to extend treatment options for other related disorders, such as Parkinson's Disease and Alzheimer's Disease. Additionally, Lucy Therapeutics is dedicated to creating proprietary small molecule therapies and diagnostic biomarkers aimed at enhancing the understanding of the central nervous system. By leveraging advanced genetic technologies, the company aims to provide insights into personalized medicine, thereby improving patient outcomes and enabling more precise healthcare interventions.

Vaxess Technologies, Inc. is a biotechnology company based in Boston, Massachusetts, founded in 2011. The company specializes in the development and commercialization of silk biomaterial technologies, particularly the MIMIX microneedle platform, which facilitates transdermal delivery of vaccines and therapeutics. This innovative sustained release patch technology enhances vaccine administration by simulating a natural infection, promoting a robust and prolonged immune response, thereby improving vaccine effectiveness. Additionally, Vaxess’s MATRIX formulation and drying platform creates thermostable vaccines, therapeutics, and diagnostic products that do not require refrigeration, making them suitable for distribution in low-resource settings. Through these advanced solutions, Vaxess aims to improve patient outcomes in oncology care and infectious diseases while reducing treatment burdens for healthcare practitioners.

Commonwealth Fusion Systems LLC is an energy research company based in Cambridge, Massachusetts, focused on developing fusion energy technology to address climate change. Established in 2017 as a spin-out from the Massachusetts Institute of Technology, the company utilizes rare-earth barium copper oxide superconductor technology to enhance fusion energy production. By integrating proven physics with advanced superconducting magnet technology, Commonwealth Fusion Systems aims to accelerate the commercialization of fusion energy. The company's efforts are directed toward designing and constructing fusion machines that promise limitless and clean energy, positioning them as a key player in the transition to renewable energy sources. Through collaboration with MIT's Plasma Science and Fusion Center, the company leverages decades of government-funded research to innovate within the private sector, ultimately contributing to the global pursuit of sustainable energy solutions.

Kytopen, established in 2017 and based in Cambridge, Massachusetts, specializes in the development of a cell therapy platform. This platform facilitates the non-viral delivery of molecules into challenging-to-transfect immune cells, making the process easier, faster, and more cost-effective. The company's proprietary Flowfect™ technology combines microfluidics and automation, enabling researchers to explore new biological discoveries and develop more affordable cell and gene therapies.

Zapata Computing, Inc. is a quantum software company that specializes in developing innovative computing solutions tailored for industrial and commercial applications. Founded in 2017 and headquartered in Boston, Massachusetts, with an additional office in Toronto, the company emerged from Harvard University and is driven by a team of scientists, including Alán Aspuru-Guzik. Zapata offers Orquestra, a software platform that enables the composition of quantum workflows using a YAML-compatible language, facilitating tasks across both quantum and classical hardware. Its solutions are hardware-agnostic and cater to various sectors, including finance, healthcare, pharmaceuticals, transportation, logistics, energy, and more. Equipped to address complex challenges, Zapata Computing focuses on simulation, optimization, and machine learning, helping enterprise organizations harness the power of quantum technology to enhance their operations.

Cellino is focused on developing a scalable, automated biomanufacturing system aimed at producing personalized cell therapies. The company's innovative platform leverages AI-guided laser editing to generate autologous induced pluripotent stem cells (iPSCs) efficiently and at scale. By utilizing image-guided machine learning, single-cell laser processing, and robotics, Cellino seeks to make advanced, potentially curative treatments accessible for a range of chronic degenerative diseases, including vision loss and Parkinson's disease. The company's mission is to transform healthcare by enabling personalized therapies that can significantly improve patient outcomes and overall health.

Via Separations, Inc. is a company that specializes in developing membrane-based products for the separation of industrial liquids, aimed at enhancing efficiency in challenging industrial environments. Founded in 2016 and based in Somerville, Massachusetts, the company focuses on industrial decarbonization through innovative chemistries that significantly reduce energy consumption in manufacturing processes. Via's technology allows facilities to cut energy usage by 90% during chemical separation, replacing traditional heat-based methods with a highly selective and robust membrane filtration system. This advancement not only helps to minimize the environmental impact of industrial processes, but it also creates additional revenue opportunities for customers. Currently, Via is conducting pilot trials at pulp and paper facilities with the goal of eliminating 100 million metric tons of CO2 emissions by 2050. The company has successfully scaled its technology and demonstrated working prototypes at a commercial level, having emerged from MIT's Department of Material Science & Engineering.

Boston Metal, founded in 2012 as a spinout from MIT, is a metallurgy company headquartered in Woburn, MA. It specializes in developing technology to reduce the carbon footprint of steel production through its Molten Oxide Electrolysis (MOE) process. This industrial-scale solution enables efficient, lower-cost, and greener production of various metals and alloys from diverse feedstocks. Boston Metal has significantly scaled its technology and produced substantial quantities of metal since its inception.

Radix Labs is a software development company based in the United States, specializing in solutions for laboratories. The company's software enables biologists to automate their laboratory processes and experimentation, enhancing efficiency and productivity. Radix Labs positions itself as the operating system for laboratories, facilitating seamless integration with existing on-premise hardware and supporting equipment from various manufacturers. This flexibility allows laboratories to optimize their operations while leveraging current technology.

HyperLight specializes in the development of thin-film lithium niobate photonic integrated circuit solutions, focusing on reducing signal loss in various applications. The company designs and manufactures integrated optical circuits, including chip-scale LN modulators and photonic chips intended for data centers, datacom, and quantum computing. By converting signals between electricity and light waves, HyperLight's products set new performance benchmarks, enabling clients to achieve efficient operations with low power consumption. The company collaborates closely with its customers throughout the entire process, from conceptualization and design to prototyping and volume production, ensuring tailored solutions that meet specific needs.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

Zapata Computing, Inc. is a quantum software company that specializes in developing innovative computing solutions tailored for industrial and commercial applications. Founded in 2017 and headquartered in Boston, Massachusetts, with an additional office in Toronto, the company emerged from Harvard University and is driven by a team of scientists, including Alán Aspuru-Guzik. Zapata offers Orquestra, a software platform that enables the composition of quantum workflows using a YAML-compatible language, facilitating tasks across both quantum and classical hardware. Its solutions are hardware-agnostic and cater to various sectors, including finance, healthcare, pharmaceuticals, transportation, logistics, energy, and more. Equipped to address complex challenges, Zapata Computing focuses on simulation, optimization, and machine learning, helping enterprise organizations harness the power of quantum technology to enhance their operations.

Finwave Semiconductor specializes in the development of advanced gallium nitride (GaN) transistors and integrated circuits (ICs) tailored for 5G communications and power conversion applications. The company utilizes a unique 3DGaN technology, specifically its differentiated fin field-effect transistor (FinFET) design, to enhance the performance of high-volume applications such as radio frequency front end (RFFE) systems for mobile devices. This innovative approach allows Finwave to create semiconductor materials with distinct properties, contributing to advancements in electronics and energy management.

Hedron is a company focused on developing a modular and scalable network of data relay satellites designed to enhance data connectivity in space. Their satellite network utilizes a hybrid RF-optical communication system to facilitate real-time communication between Earth and low-earth-orbiting satellites. By offering advanced data connectivity solutions, Hedron aims to address critical global challenges such as food and water security, climate change monitoring, and disaster mitigation. The company's imaging satellites generate valuable data that provide insights to optimize the global economy and improve understanding of the planet. Through its innovative approach, Hedron is positioned to create new opportunities for advancements in space technology and data utilization.

Suono Bio, Inc. is a biotechnology company based in Medford, Massachusetts, that focuses on designing and developing innovative therapeutic products with a unique delivery technology. Established in 2016, the company specializes in enabling ultra-rapid, localized delivery of small molecules, biologics, nucleic acids, and gene therapies directly to the gastrointestinal tract without the need for encapsulation. Suono Bio aims to transform the treatment landscape for difficult-to-treat diseases, particularly those mediated by inflammatory processes, by facilitating effective therapy delivery that enhances patient recovery from gastrointestinal conditions.

Kytopen, established in 2017 and based in Cambridge, Massachusetts, specializes in the development of a cell therapy platform. This platform facilitates the non-viral delivery of molecules into challenging-to-transfect immune cells, making the process easier, faster, and more cost-effective. The company's proprietary Flowfect™ technology combines microfluidics and automation, enabling researchers to explore new biological discoveries and develop more affordable cell and gene therapies.

Via Separations, Inc. is a company that specializes in developing membrane-based products for the separation of industrial liquids, aimed at enhancing efficiency in challenging industrial environments. Founded in 2016 and based in Somerville, Massachusetts, the company focuses on industrial decarbonization through innovative chemistries that significantly reduce energy consumption in manufacturing processes. Via's technology allows facilities to cut energy usage by 90% during chemical separation, replacing traditional heat-based methods with a highly selective and robust membrane filtration system. This advancement not only helps to minimize the environmental impact of industrial processes, but it also creates additional revenue opportunities for customers. Currently, Via is conducting pilot trials at pulp and paper facilities with the goal of eliminating 100 million metric tons of CO2 emissions by 2050. The company has successfully scaled its technology and demonstrated working prototypes at a commercial level, having emerged from MIT's Department of Material Science & Engineering.

Baseload Renewables develops low-cost energy storage to replace fossil base-load generation with renewable energy.

C2Sense, Inc., founded in 2013 and based in Cambridge, Massachusetts, specializes in developing chemiresistive gas sensors for applications in food and agriculture. Their sensors are designed to detect gases such as ethylene and biogenic amines at low concentrations, monitoring fruit ripeness and the freshness of meat, fish, and poultry throughout the supply chain. This technology helps improve food quality and reduce waste by enabling informed decisions at every stage from growers to consumers. Additionally, C2Sense is working on Halo Diagnostics, a digitally connected immunoassay reader that provides near-PCR sensitivity for patient-to-provider workflows. The company also offers sensing solutions for product quality information and counterfeit detection, using molecular additives that can be integrated into products or packaging to provide real-time status updates and detect issues during distribution.

ISEE, Inc. is an autonomous driving technology company based in Cambridge, Massachusetts, established in 2016. The company specializes in developing artificial intelligence-based software and hardware solutions for self-driving vehicles, particularly focusing on automating logistics and supply chain operations. ISEE's innovative platform utilizes advanced AI to understand uncertainty, predict human behavior, and assess risk and efficiency, thereby enhancing the operational capabilities of autonomous machines. Its autonomous yard trucks are designed to improve safety, cost-effectiveness, and driving performance for major clients, including prominent companies in the retail and shipping industries. By leveraging its proprietary technology, ISEE aims to modernize supply chain logistics and contribute to seamless integration of autonomous systems in real-world applications.