The Engine

BlueShift is a climate technology company that specializes in electrochemical processes. It develops systems to capture carbon dioxide directly from the ocean and convert industrial waste into valuable minerals, such as nickel and carbonates. This process not only provides sustainable sources for these materials but also significantly reduces atmospheric carbon, contributing to climate change mitigation.

VEIR is a company focused on innovative electricity transmission solutions using high-temperature superconductors. It has developed a unique passive evaporative cryogenic cooling technology that significantly enhances cooling efficiency, delivering twenty times the cooling power per kilogram of nitrogen flow compared to traditional mechanical methods. By utilizing commercial superconducting tape, VEIR's technology enables power delivery at transmission levels without resistive losses. This advancement allows clients to streamline permitting processes and supports the economical establishment of electric transmission lines across distribution-scale infrastructure.

Osmoses specializes in decarbonizing gas separations using innovative membrane technology. Its solution efficiently purifies gas molecules, reducing energy consumption and capital requirements while integrating seamlessly into existing industrial processes. This enables energy producers to achieve cleaner and more sustainable operations.

Vaxess Technologies is a biotechnology company focused on silk biomaterial platforms for vaccine and therapeutic delivery. It develops the MIMIX microneedle patch for transdermal, sustained-release delivery of vaccines and therapies, designed to improve stability and ease of use, including formulations that do not require cold chain storage. The MATRIX formulation and drying platform supports thermostable vaccine, therapeutic, and diagnostic products. The company aims to enable long-term immune responses and easier distribution, including in low-resource settings. Its technology supports oncology and infectious disease applications, including therapies that promote durable anti-tumor immunity and improved treatment outcomes. Founded in 2011 and based in Boston, the company positions its platforms to enable stable, targeted delivery and potentially reduce treatment burden for patients.

Amide specializes in custom peptide synthesis services for drug discovery. Utilizing advanced flow chemistry techniques, they offer rapid and reliable production of peptides with extensive amino acid sequences, enabling pharmaceutical companies to accelerate their research and access complex compounds efficiently.

Celestial AI develops a data center and artificial intelligence computing platform that uses photonics, mixed-signal ASICs, and advanced packaging to deliver sustainable improvements in AI acceleration hardware and software. Its Photonic Fabric technology enables optically scalable, disaggregated data center computing and memory, supporting deep learning and machine learning workloads. The company aims to provide an integrated platform that enhances AI performance while reducing energy use and total cost of ownership.

Hyfé is a feedstock processing company focused on transforming food waste into valuable chemicals and materials, thereby promoting sustainability in various industries. By utilizing fungal fermentation, Hyfé upcycles waste generated during food manufacturing, enabling the production of cost-competitive essential goods. This innovative approach not only maximizes profits for food manufacturers but also contributes to reducing the carbon footprint of the food industry. Through its commitment to creating sustainable chemicals, materials, fuels, and foods, Hyfé aims to unlock the full value of every crop while providing alternatives to petroleum-based products.

VEIR is a company focused on innovative electricity transmission solutions using high-temperature superconductors. It has developed a unique passive evaporative cryogenic cooling technology that significantly enhances cooling efficiency, delivering twenty times the cooling power per kilogram of nitrogen flow compared to traditional mechanical methods. By utilizing commercial superconducting tape, VEIR's technology enables power delivery at transmission levels without resistive losses. This advancement allows clients to streamline permitting processes and supports the economical establishment of electric transmission lines across distribution-scale infrastructure.

Droplet Biosciences enhances cancer diagnosis through its innovative lymphatic fluid analysis technology. This non-invasive liquid biopsy method enables healthcare professionals to make more informed post-operative treatment decisions.

Sublime Systems is a company focused on decarbonizing cement production through innovative technology that simultaneously generates green hydrogen and reduces carbon emissions. Their approach employs an electrochemical method powered by clean, renewable energy, effectively eliminating CO2 emissions while preserving the essential characteristics and chemistry of the cement. This technology allows builders and consumers to actively participate in the transition towards a sustainable and renewable future, aligning with global efforts to mitigate climate change.

Vaxess Technologies is a biotechnology company focused on silk biomaterial platforms for vaccine and therapeutic delivery. It develops the MIMIX microneedle patch for transdermal, sustained-release delivery of vaccines and therapies, designed to improve stability and ease of use, including formulations that do not require cold chain storage. The MATRIX formulation and drying platform supports thermostable vaccine, therapeutic, and diagnostic products. The company aims to enable long-term immune responses and easier distribution, including in low-resource settings. Its technology supports oncology and infectious disease applications, including therapies that promote durable anti-tumor immunity and improved treatment outcomes. Founded in 2011 and based in Boston, the company positions its platforms to enable stable, targeted delivery and potentially reduce treatment burden for patients.

Syzygy Plasmonics, Inc. is a Houston-based company that specializes in the design, development, and manufacturing of photocatalytic reactor systems for industrial chemical reactions. Founded in 2017, the company focuses on creating reactors that facilitate the generation of fuel cell quality hydrogen from ammonia, specifically for small-to-medium-scale applications. These advanced reactors operate at significantly lower temperatures than traditional chemical reactors, allowing for reduced maintenance costs and the ability to quickly start or stop production. By utilizing light as an energy source, Syzygy Plasmonics enables the integration of renewable electricity into chemical manufacturing, contributing to the decarbonization of various industries and supporting the on-site production of ultra-low-cost hydrogen gas for fuel cell vehicles.

Vaxess Technologies is a biotechnology company focused on silk biomaterial platforms for vaccine and therapeutic delivery. It develops the MIMIX microneedle patch for transdermal, sustained-release delivery of vaccines and therapies, designed to improve stability and ease of use, including formulations that do not require cold chain storage. The MATRIX formulation and drying platform supports thermostable vaccine, therapeutic, and diagnostic products. The company aims to enable long-term immune responses and easier distribution, including in low-resource settings. Its technology supports oncology and infectious disease applications, including therapies that promote durable anti-tumor immunity and improved treatment outcomes. Founded in 2011 and based in Boston, the company positions its platforms to enable stable, targeted delivery and potentially reduce treatment burden for patients.

Axoft develops implantable, bioinspired electronics that enable long-term communication with the nervous system to improve clinical outcomes and overall health. The company creates ultra-flexible plastic mesh implants housing multiple sensors that closely match brain tissue mechanics, aiming to reduce tissue response and enable precise monitoring and intervention for neurodegenerative conditions. By enhancing brain–machine communication, Axoft seeks to provide more effective treatments for patients with Parkinson's disease and related disorders, supporting tailored therapies and better patient outcomes.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

Mantel develops innovative carbon capture technology designed for use within boilers, kilns, and furnaces. Their method reduces energy losses and enables net-negative emissions, targeting gigaton-level carbon removal. This helps mitigate sustainability concerns across industries such as industrial heat, steel, and chemicals.

Sync Computing Corp., established in 2019 and headquartered in Cambridge, Massachusetts, specializes in manufacturing Optimization Processing Units (OPUs). These units are designed to tackle combinatorial optimization problems across various sectors such as telecom, pharma, finance, logistics, and machine learning-dependent industries. Sync Computing's OPU is essentially an algorithm in hardware form, enabling organizations to efficiently solve complex optimization challenges.

Founded in 2022, Atlantic Quantum specializes in developing scalable quantum computers to address complex computational challenges. The company focuses on creating fault-tolerant quantum hardware as a key step towards advancing quantum computing.

Foundation Alloy specializes in designing novel alloys optimized for additive manufacturing using advanced materials technology. The company aims to make metal part manufacturing more environmentally sustainable and cost-effective, enabling engineers to enhance performance and production efficiency.

Hyfé is a feedstock processing company focused on transforming food waste into valuable chemicals and materials, thereby promoting sustainability in various industries. By utilizing fungal fermentation, Hyfé upcycles waste generated during food manufacturing, enabling the production of cost-competitive essential goods. This innovative approach not only maximizes profits for food manufacturers but also contributes to reducing the carbon footprint of the food industry. Through its commitment to creating sustainable chemicals, materials, fuels, and foods, Hyfé aims to unlock the full value of every crop while providing alternatives to petroleum-based products.

Seaspire Skincare specializes in developing multifunctional colorants and actives inspired by ocean biodiversity. Its flagship product, Xanthochrome, offers broader UV protection and aims to replace harmful ingredients in skincare products, promoting sustainability and reduced adverse effects on human and marine health.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Founded in 2018, Quaise is an innovative energy company based in Cambridge, Massachusetts. It specializes in developing and commercializing advanced millimeter-wave drilling systems to access geothermal energy sources worldwide, overcoming geographical limitations.

Celestial AI is a prominent artificial intelligence company that provides an advanced platform for users to efficiently create images, text, and presentations. Utilizing cutting-edge computer vision algorithms and natural language processing, the platform produces high-quality visual and textual content. Its intuitive design, combined with innovative features, facilitates easy content creation. Moreover, Celestial AI emphasizes intelligent data integration and prioritizes security, ensuring that users achieve impressive and reliable results.

Founded in 2017, Resonant Link specializes in developing and manufacturing advanced wireless charging solutions. Utilizing coil technology, their products offer highly efficient power transfer for a wide range of applications, from electric vehicles to medical devices.

Sync Computing Corp., established in 2019 and headquartered in Cambridge, Massachusetts, specializes in manufacturing Optimization Processing Units (OPUs). These units are designed to tackle combinatorial optimization problems across various sectors such as telecom, pharma, finance, logistics, and machine learning-dependent industries. Sync Computing's OPU is essentially an algorithm in hardware form, enabling organizations to efficiently solve complex optimization challenges.

Cellino develops scalable, automated biomanufacturing systems for personalized cell therapies based on induced pluripotent stem cells (iPSCs). The company aims to enable potentially curative, patient-specific treatments by producing autologous iPSCs at scale and applying AI-guided, image-driven laser processing and robotics to remove unwanted cells. By integrating image-guided machine learning, single-cell laser processing, and robotics, Cellino seeks to enhance precision, efficiency, and scalability in optical bioprocessing, accelerating the development of regenerative therapies for chronic degenerative diseases such as vision loss and Parkinson's disease.

Founded in 2017, Commonwealth Fusion is a research company developing fusion energy through an inexhaustible power plant. It combines proven physics with revolutionary superconducting magnet technology to accelerate the path to commercial fusion energy.

Osmoses specializes in decarbonizing gas separations using innovative membrane technology. Its solution efficiently purifies gas molecules, reducing energy consumption and capital requirements while integrating seamlessly into existing industrial processes. This enables energy producers to achieve cleaner and more sustainable operations.

Hedron is a company focused on developing a modular and scalable network of data relay satellites designed to enhance data connectivity in space. Their satellite network utilizes a hybrid RF-optical communication system to facilitate real-time communication between Earth and low-earth-orbiting satellites. By offering advanced data connectivity solutions, Hedron aims to address critical global challenges such as food and water security, climate change monitoring, and disaster mitigation. The company's imaging satellites generate valuable data that provide insights to optimize the global economy and improve understanding of the planet. Through its innovative approach, Hedron is positioned to create new opportunities for advancements in space technology and data utilization.

Via Separations, Inc. is a company that specializes in developing membrane-based products for the separation of industrial liquids, aimed at enhancing efficiency in challenging industrial environments. Founded in 2016 and based in Somerville, Massachusetts, the company focuses on industrial decarbonization through innovative chemistries that significantly reduce energy consumption in manufacturing processes. Via's technology allows facilities to cut energy usage by 90% during chemical separation, replacing traditional heat-based methods with a highly selective and robust membrane filtration system. This advancement not only helps to minimize the environmental impact of industrial processes, but it also creates additional revenue opportunities for customers. Currently, Via is conducting pilot trials at pulp and paper facilities with the goal of eliminating 100 million metric tons of CO2 emissions by 2050. The company has successfully scaled its technology and demonstrated working prototypes at a commercial level, having emerged from MIT's Department of Material Science & Engineering.

Kytopen Corp., founded in 2017, develops proprietary Flowfect™ technology for non-viral delivery of molecules into hard-to-transfect immune cells. Its platform combines microfluidics and automation to facilitate efficient cell engineering.

Lilac Solutions, Inc. is a mining technology company based in Oakland, California, specializing in lithium extraction technology. Founded in 2015, the company develops innovative solutions that utilize ion-exchange theory to absorb lithium from brine deposits. This technology includes ion exchange beads and continuous brine processing systems, which enable lithium producers to enhance project development, increase lithium recovery, and optimize operations. Lilac Solutions aims to support industries such as electric vehicles and renewable energy storage by providing methods that reduce both costs and environmental impact associated with lithium production.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

Emvolon is a technology company focused on creating a platform for distributed chemical production that utilizes wasted resources. The company's innovative approach involves converting wasted natural gas from flare sites into usable chemicals, which can serve a variety of industrial applications or be transformed into carbon-negative fuels. Emvolon reimagines traditional diesel engines as miniature chemical reactors, allowing for efficient and effective production without the need for large refineries or chemical plants. This process facilitates the establishment of economically viable small-scale production facilities by leveraging the advantages of mass production alongside economies of scale, ultimately providing communities with the essential raw materials they require.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Syzygy Plasmonics, Inc. is a Houston-based company that specializes in the design, development, and manufacturing of photocatalytic reactor systems for industrial chemical reactions. Founded in 2017, the company focuses on creating reactors that facilitate the generation of fuel cell quality hydrogen from ammonia, specifically for small-to-medium-scale applications. These advanced reactors operate at significantly lower temperatures than traditional chemical reactors, allowing for reduced maintenance costs and the ability to quickly start or stop production. By utilizing light as an energy source, Syzygy Plasmonics enables the integration of renewable electricity into chemical manufacturing, contributing to the decarbonization of various industries and supporting the on-site production of ultra-low-cost hydrogen gas for fuel cell vehicles.

VEIR is a company focused on innovative electricity transmission solutions using high-temperature superconductors. It has developed a unique passive evaporative cryogenic cooling technology that significantly enhances cooling efficiency, delivering twenty times the cooling power per kilogram of nitrogen flow compared to traditional mechanical methods. By utilizing commercial superconducting tape, VEIR's technology enables power delivery at transmission levels without resistive losses. This advancement allows clients to streamline permitting processes and supports the economical establishment of electric transmission lines across distribution-scale infrastructure.

Cellino develops scalable, automated biomanufacturing systems for personalized cell therapies based on induced pluripotent stem cells (iPSCs). The company aims to enable potentially curative, patient-specific treatments by producing autologous iPSCs at scale and applying AI-guided, image-driven laser processing and robotics to remove unwanted cells. By integrating image-guided machine learning, single-cell laser processing, and robotics, Cellino seeks to enhance precision, efficiency, and scalability in optical bioprocessing, accelerating the development of regenerative therapies for chronic degenerative diseases such as vision loss and Parkinson's disease.

Celestial AI is a prominent artificial intelligence company that provides an advanced platform for users to efficiently create images, text, and presentations. Utilizing cutting-edge computer vision algorithms and natural language processing, the platform produces high-quality visual and textual content. Its intuitive design, combined with innovative features, facilitates easy content creation. Moreover, Celestial AI emphasizes intelligent data integration and prioritizes security, ensuring that users achieve impressive and reliable results.

Boston Metal is a metallurgy company specializing in reducing the carbon footprint of steel production. It offers industrial-scale solutions using its Molten Oxide Electrolysis (MOE) process, enabling greener and more efficient metal production.

Founded by MIT researchers and industry veterans in 2018, The Routing Company develops a real-time driver and rider application for shared rides. It offers fleet management solutions, including private fleets, demand-responsive transit, analytics dashboards, and transit/paratransit services. Leveraging proprietary AI, the company's platform optimizes vehicle routing from multiple points of demand to one vehicle, enhancing transport equity, accessibility, cost efficiency, and sustainability.

Zapata Computing, Inc. is a quantum software company that specializes in developing innovative computing solutions tailored for industrial and commercial applications. Founded in 2017 and headquartered in Boston, Massachusetts, with an additional office in Toronto, the company emerged from Harvard University and is driven by a team of scientists, including Alán Aspuru-Guzik. Zapata offers Orquestra, a software platform that enables the composition of quantum workflows using a YAML-compatible language, facilitating tasks across both quantum and classical hardware. Its solutions are hardware-agnostic and cater to various sectors, including finance, healthcare, pharmaceuticals, transportation, logistics, energy, and more. Equipped to address complex challenges, Zapata Computing focuses on simulation, optimization, and machine learning, helping enterprise organizations harness the power of quantum technology to enhance their operations.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

WoHo is a company based in Cambridge, Massachusetts, founded in 2020, that focuses on innovative construction systems and technology. It aims to revolutionize the building process by assembling teams, networks, and systems to create both low and high-rise structures with exceptional quality, precision, and efficiency. WoHo's platform integrates architecture, engineering, and construction, providing clients with sustainable and cost-effective solutions for various living and working spaces. By streamlining these processes, WoHo offers competitive alternatives in the construction industry, enhancing the overall efficiency of project delivery.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Founded in 2018, Quaise is an innovative energy company based in Cambridge, Massachusetts. It specializes in developing and commercializing advanced millimeter-wave drilling systems to access geothermal energy sources worldwide, overcoming geographical limitations.

Founded in 2017, Commonwealth Fusion is a research company developing fusion energy through an inexhaustible power plant. It combines proven physics with revolutionary superconducting magnet technology to accelerate the path to commercial fusion energy.

Biobot Analytics, Inc. is a wastewater epidemiology company based in Cambridge, Massachusetts, founded in 2017. It specializes in transforming wastewater infrastructure into public health observatories through innovative technology that analyzes sewage for health-related data. By deploying proprietary sampling devices and spatial analytics, Biobot measures various health threats, including infectious diseases, antibiotic resistance, and drug consumption patterns. The company's Opioid Consumption Monitoring Program specifically estimates opioid use in urban areas by analyzing wastewater. This approach generates anonymized public health data that is independent of traditional hospital reporting systems, allowing for rapid adaptability to emerging public health threats. Biobot Analytics offers its insights as a service, providing government officials with actionable data to prioritize interventions and address public health challenges effectively.

Rise Robotics, based in Somerville, Massachusetts, specializes in designing and manufacturing innovative robotic components inspired by biological systems. Founded in 2011, the company aims to revolutionize the robotics industry by creating powerful wearable ExoSUITS. Their flagship product, the Cyclone Muscle, is a lightweight electric linear actuator that effectively transforms rotary motor motion into linear muscle-like actuation, addressing the critical balance between force, speed, and control. Additionally, Rise Robotics has developed the Bacon Robotic Air Compressor, which enhances traditional handheld air compressors through its unique Cyclone Linear Drive technology. This breakthrough innovation positions Rise Robotics at the forefront of advancing mobile robotic applications.

Lilac Solutions, Inc. is a mining technology company based in Oakland, California, specializing in lithium extraction technology. Founded in 2015, the company develops innovative solutions that utilize ion-exchange theory to absorb lithium from brine deposits. This technology includes ion exchange beads and continuous brine processing systems, which enable lithium producers to enhance project development, increase lithium recovery, and optimize operations. Lilac Solutions aims to support industries such as electric vehicles and renewable energy storage by providing methods that reduce both costs and environmental impact associated with lithium production.

Seaspire Skincare specializes in developing multifunctional colorants and actives inspired by ocean biodiversity. Its flagship product, Xanthochrome, offers broader UV protection and aims to replace harmful ingredients in skincare products, promoting sustainability and reduced adverse effects on human and marine health.

Sync Computing Corp., established in 2019 and headquartered in Cambridge, Massachusetts, specializes in manufacturing Optimization Processing Units (OPUs). These units are designed to tackle combinatorial optimization problems across various sectors such as telecom, pharma, finance, logistics, and machine learning-dependent industries. Sync Computing's OPU is essentially an algorithm in hardware form, enabling organizations to efficiently solve complex optimization challenges.

ISEE develops AI-based solutions for autonomous driving in logistics. Founded in 2016, the company is headquartered in Cambridge, Massachusetts. ISEE's autonomous yard trucks help businesses like Maersk automate their logistics hubs, improving safety, reducing costs, and enhancing driving performance.

E25Bio Inc. is a biotechnology company based in Cambridge, Massachusetts, founded in 2018, that focuses on developing rapid diagnostic tests for epidemic fever viruses. The company designs paper-based diagnostic systems and kits that facilitate the detection of viruses such as dengue, chikungunya, and Zika. E25Bio's innovative platform enables multiplexed testing that quickly identifies viral antigens during infections, allowing for real-time data reporting through a mobile application. This capability supports epidemiologic predictions and disease mapping, empowering governments and health organizations to respond effectively to outbreaks and manage public health crises. Through its commitment to fast, mobile testing solutions, E25Bio aims to prevent severe health outcomes associated with viral epidemics.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

Syzygy Plasmonics, Inc. is a Houston-based company that specializes in the design, development, and manufacturing of photocatalytic reactor systems for industrial chemical reactions. Founded in 2017, the company focuses on creating reactors that facilitate the generation of fuel cell quality hydrogen from ammonia, specifically for small-to-medium-scale applications. These advanced reactors operate at significantly lower temperatures than traditional chemical reactors, allowing for reduced maintenance costs and the ability to quickly start or stop production. By utilizing light as an energy source, Syzygy Plasmonics enables the integration of renewable electricity into chemical manufacturing, contributing to the decarbonization of various industries and supporting the on-site production of ultra-low-cost hydrogen gas for fuel cell vehicles.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Lucy Therapeutics is a biotechnology company focused on developing innovative treatments for neurological diseases by targeting mitochondrial dysfunction. The company employs a unique approach to drug discovery, concentrating on drugging targets linked to the early stages of disease pathogenesis. This methodology not only addresses specific neurological conditions but also has the potential to extend treatment options for other related disorders, such as Parkinson's Disease and Alzheimer's Disease. Additionally, Lucy Therapeutics is dedicated to creating proprietary small molecule therapies and diagnostic biomarkers aimed at enhancing the understanding of the central nervous system. By leveraging advanced genetic technologies, the company aims to provide insights into personalized medicine, thereby improving patient outcomes and enabling more precise healthcare interventions.

Vaxess Technologies is a biotechnology company focused on silk biomaterial platforms for vaccine and therapeutic delivery. It develops the MIMIX microneedle patch for transdermal, sustained-release delivery of vaccines and therapies, designed to improve stability and ease of use, including formulations that do not require cold chain storage. The MATRIX formulation and drying platform supports thermostable vaccine, therapeutic, and diagnostic products. The company aims to enable long-term immune responses and easier distribution, including in low-resource settings. Its technology supports oncology and infectious disease applications, including therapies that promote durable anti-tumor immunity and improved treatment outcomes. Founded in 2011 and based in Boston, the company positions its platforms to enable stable, targeted delivery and potentially reduce treatment burden for patients.

Founded in 2017, Commonwealth Fusion is a research company developing fusion energy through an inexhaustible power plant. It combines proven physics with revolutionary superconducting magnet technology to accelerate the path to commercial fusion energy.

Kytopen Corp., founded in 2017, develops proprietary Flowfect™ technology for non-viral delivery of molecules into hard-to-transfect immune cells. Its platform combines microfluidics and automation to facilitate efficient cell engineering.

Zapata Computing, Inc. is a quantum software company that specializes in developing innovative computing solutions tailored for industrial and commercial applications. Founded in 2017 and headquartered in Boston, Massachusetts, with an additional office in Toronto, the company emerged from Harvard University and is driven by a team of scientists, including Alán Aspuru-Guzik. Zapata offers Orquestra, a software platform that enables the composition of quantum workflows using a YAML-compatible language, facilitating tasks across both quantum and classical hardware. Its solutions are hardware-agnostic and cater to various sectors, including finance, healthcare, pharmaceuticals, transportation, logistics, energy, and more. Equipped to address complex challenges, Zapata Computing focuses on simulation, optimization, and machine learning, helping enterprise organizations harness the power of quantum technology to enhance their operations.

Cellino develops scalable, automated biomanufacturing systems for personalized cell therapies based on induced pluripotent stem cells (iPSCs). The company aims to enable potentially curative, patient-specific treatments by producing autologous iPSCs at scale and applying AI-guided, image-driven laser processing and robotics to remove unwanted cells. By integrating image-guided machine learning, single-cell laser processing, and robotics, Cellino seeks to enhance precision, efficiency, and scalability in optical bioprocessing, accelerating the development of regenerative therapies for chronic degenerative diseases such as vision loss and Parkinson's disease.

Via Separations, Inc. is a company that specializes in developing membrane-based products for the separation of industrial liquids, aimed at enhancing efficiency in challenging industrial environments. Founded in 2016 and based in Somerville, Massachusetts, the company focuses on industrial decarbonization through innovative chemistries that significantly reduce energy consumption in manufacturing processes. Via's technology allows facilities to cut energy usage by 90% during chemical separation, replacing traditional heat-based methods with a highly selective and robust membrane filtration system. This advancement not only helps to minimize the environmental impact of industrial processes, but it also creates additional revenue opportunities for customers. Currently, Via is conducting pilot trials at pulp and paper facilities with the goal of eliminating 100 million metric tons of CO2 emissions by 2050. The company has successfully scaled its technology and demonstrated working prototypes at a commercial level, having emerged from MIT's Department of Material Science & Engineering.

Boston Metal is a metallurgy company specializing in reducing the carbon footprint of steel production. It offers industrial-scale solutions using its Molten Oxide Electrolysis (MOE) process, enabling greener and more efficient metal production.

Radix Labs is a software development company based in the United States, specializing in solutions for laboratories. The company's software enables biologists to automate their laboratory processes and experimentation, enhancing efficiency and productivity. Radix Labs positions itself as the operating system for laboratories, facilitating seamless integration with existing on-premise hardware and supporting equipment from various manufacturers. This flexibility allows laboratories to optimize their operations while leveraging current technology.

Hyperlight specializes in thin-film lithium niobate photonic integrated circuits. They offer innovative electro-optic and nonlinear optical solutions with scalable manufacturing processes, collaborating closely with customers from initial concept to volume production.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

Zapata Computing, Inc. is a quantum software company that specializes in developing innovative computing solutions tailored for industrial and commercial applications. Founded in 2017 and headquartered in Boston, Massachusetts, with an additional office in Toronto, the company emerged from Harvard University and is driven by a team of scientists, including Alán Aspuru-Guzik. Zapata offers Orquestra, a software platform that enables the composition of quantum workflows using a YAML-compatible language, facilitating tasks across both quantum and classical hardware. Its solutions are hardware-agnostic and cater to various sectors, including finance, healthcare, pharmaceuticals, transportation, logistics, energy, and more. Equipped to address complex challenges, Zapata Computing focuses on simulation, optimization, and machine learning, helping enterprise organizations harness the power of quantum technology to enhance their operations.

Finwave Semiconductor specializes in the development of advanced gallium nitride (GaN) transistors and integrated circuits (ICs) tailored for 5G communications and power conversion applications. The company utilizes a unique 3DGaN technology, specifically its differentiated fin field-effect transistor (FinFET) design, to enhance the performance of high-volume applications such as radio frequency front end (RFFE) systems for mobile devices. This innovative approach allows Finwave to create semiconductor materials with distinct properties, contributing to advancements in electronics and energy management.

Hedron is a company focused on developing a modular and scalable network of data relay satellites designed to enhance data connectivity in space. Their satellite network utilizes a hybrid RF-optical communication system to facilitate real-time communication between Earth and low-earth-orbiting satellites. By offering advanced data connectivity solutions, Hedron aims to address critical global challenges such as food and water security, climate change monitoring, and disaster mitigation. The company's imaging satellites generate valuable data that provide insights to optimize the global economy and improve understanding of the planet. Through its innovative approach, Hedron is positioned to create new opportunities for advancements in space technology and data utilization.

Suono Bio, Inc. is a biotechnology company based in Medford, Massachusetts, that focuses on designing and developing innovative therapeutic products with a unique delivery technology. Established in 2016, the company specializes in enabling ultra-rapid, localized delivery of small molecules, biologics, nucleic acids, and gene therapies directly to the gastrointestinal tract without the need for encapsulation. Suono Bio aims to transform the treatment landscape for difficult-to-treat diseases, particularly those mediated by inflammatory processes, by facilitating effective therapy delivery that enhances patient recovery from gastrointestinal conditions.

Kytopen Corp., founded in 2017, develops proprietary Flowfect™ technology for non-viral delivery of molecules into hard-to-transfect immune cells. Its platform combines microfluidics and automation to facilitate efficient cell engineering.

Via Separations, Inc. is a company that specializes in developing membrane-based products for the separation of industrial liquids, aimed at enhancing efficiency in challenging industrial environments. Founded in 2016 and based in Somerville, Massachusetts, the company focuses on industrial decarbonization through innovative chemistries that significantly reduce energy consumption in manufacturing processes. Via's technology allows facilities to cut energy usage by 90% during chemical separation, replacing traditional heat-based methods with a highly selective and robust membrane filtration system. This advancement not only helps to minimize the environmental impact of industrial processes, but it also creates additional revenue opportunities for customers. Currently, Via is conducting pilot trials at pulp and paper facilities with the goal of eliminating 100 million metric tons of CO2 emissions by 2050. The company has successfully scaled its technology and demonstrated working prototypes at a commercial level, having emerged from MIT's Department of Material Science & Engineering.

Baseload Renewables develops low-cost energy storage to replace fossil base-load generation with renewable energy.

C2Sense develops chemiresistive gas sensors for food and agriculture applications, monitoring fruit ripeness and meat/fish/poultry freshness. Its sensors detect ethylene and biogenic amines at low concentrations, helping reduce waste throughout the supply chain.

ISEE develops AI-based solutions for autonomous driving in logistics. Founded in 2016, the company is headquartered in Cambridge, Massachusetts. ISEE's autonomous yard trucks help businesses like Maersk automate their logistics hubs, improving safety, reducing costs, and enhancing driving performance.