The Engine

BlueShift operates as an electrochemical climate tech innovator. BlueShift unlocks underutilized resources with advanced electrochemical technology.

VEIR is focused on advancing electricity transmission through the development of high-temperature superconductors and innovative cooling solutions. The company has created a passive evaporative cryogenic cooling technology that significantly enhances cooling efficiency, delivering 20 times more cooling power per kilogram of nitrogen flow compared to traditional mechanical subcooling methods. By utilizing commercial superconducting tape, VEIR's technology facilitates power delivery at transmission levels over distribution-scale infrastructure without resistive losses. This approach allows clients to streamline permitting processes and create economically viable electric transmission lines, thereby addressing the challenges associated with cooling high-temperature superconductors.

Osmoses specializes in clean membrane technology aimed at decarbonizing gas separations, with a goal of eliminating one gigaton of carbon emissions annually. The company has developed advanced molecular filters that offer exceptional size selectivity, enabling the purification of hydrogen and natural gas. Additionally, these filters facilitate large-scale carbon capture, significantly transforming traditional chemical separation processes. By reducing energy consumption and carbon emissions in industrial operations, Osmoses provides a solution that helps businesses lower costs, minimize product loss, and create value for their clients, contributing to broader efforts in combating climate change.

Vaxess Technologies, Inc. is a biotechnology company based in Boston, Massachusetts, founded in 2011. The company focuses on developing and commercializing innovative silk biomaterial technologies. Its key product, the MIMIX microneedle platform, facilitates the transdermal delivery of vaccines and therapeutics. This sustained release patch technology allows for a controlled release of vaccines, mimicking the natural infection process to enhance immune response and effectiveness. Vaxess's patch is engineered for stability, eliminating the need for refrigeration, which enables shipping and application in low-resource settings. In addition to its vaccine delivery systems, Vaxess is also engaged in creating novel therapies aimed at oncology care and infectious diseases, ultimately striving to improve patient outcomes with reduced treatment burdens.

Amide specializes in synthesizing complex peptides that are challenging to produce through conventional methods, effectively bridging traditional solid phase peptide synthesis and biological expression. The company utilizes unnatural amino acids and artificial protein backbones to enhance biological possibilities. Its Automated Fast Flow Peptide Synthesizer (AFPS) employs flow chemistry to significantly improve synthesis efficiency by generating highly reactive intermediates in situ, while also ensuring optimal heat and mass transfer. This innovative approach results in superior synthetic outcomes compared to traditional methods. By harnessing on-demand chemistry, Amide aims to facilitate the development of safe and effective protein therapeutics, ultimately enabling healthcare professionals to deliver next-generation treatments that enhance patient health.

Celestial AI is a machine learning accelerator company focused on developing an advanced optical interconnect technology platform for data centers and AI applications. By leveraging photonics, mixed-signal ASICs, and innovative packaging techniques, the company aims to enhance computing performance sustainably. Its proprietary Photonic FabricTM serves as the core technology for creating optically scalable and disaggregated data center computing and memory systems. This technology is designed to enable significant advancements in artificial intelligence, allowing clients to provide superior AI acceleration hardware and software solutions.

Hyfé is a feedstock processing company focused on transforming food waste into valuable chemicals, materials, fuels, and foods through fungal fermentation. By upcycling waste generated in food manufacturing, Hyfé aims to create sustainable, cost-competitive products that benefit various industries. This innovative approach not only maximizes profits for food manufacturers but also helps reduce the carbon footprint of the food industry, promoting a more sustainable future. The company is dedicated to unlocking the full value of crops, allowing for the production of essential goods without reliance on petroleum.

VEIR is focused on advancing electricity transmission through the development of high-temperature superconductors and innovative cooling solutions. The company has created a passive evaporative cryogenic cooling technology that significantly enhances cooling efficiency, delivering 20 times more cooling power per kilogram of nitrogen flow compared to traditional mechanical subcooling methods. By utilizing commercial superconducting tape, VEIR's technology facilitates power delivery at transmission levels over distribution-scale infrastructure without resistive losses. This approach allows clients to streamline permitting processes and create economically viable electric transmission lines, thereby addressing the challenges associated with cooling high-temperature superconductors.

Droplet Biosciences is a molecular diagnostics company focused on enhancing cancer care through innovative lymphatic fluid analysis. By utilizing non-invasive liquid biopsy techniques, the company aims to deliver earlier and more accurate cancer diagnoses. This approach not only improves the sensitivity of cancer detection but also assists healthcare professionals in making informed post-operative treatment decisions, ultimately contributing to better patient outcomes in cancer management.

Sublime Systems specializes in decarbonizing cement through innovative technology that co-produces green hydrogen while significantly reducing emissions. The company employs an electrochemical process powered by clean, renewable energy, effectively eliminating carbon dioxide emissions without altering the cement's properties or chemistry. This approach allows builders and consumers to actively participate in the transition towards a sustainable and renewable future.

Vaxess Technologies, Inc. is a biotechnology company based in Boston, Massachusetts, founded in 2011. The company focuses on developing and commercializing innovative silk biomaterial technologies. Its key product, the MIMIX microneedle platform, facilitates the transdermal delivery of vaccines and therapeutics. This sustained release patch technology allows for a controlled release of vaccines, mimicking the natural infection process to enhance immune response and effectiveness. Vaxess's patch is engineered for stability, eliminating the need for refrigeration, which enables shipping and application in low-resource settings. In addition to its vaccine delivery systems, Vaxess is also engaged in creating novel therapies aimed at oncology care and infectious diseases, ultimately striving to improve patient outcomes with reduced treatment burdens.

Syzygy Plasmonics, Inc. is a Houston-based company that designs, develops, and manufactures photocatalytic reactor systems for industrial chemical reactions. Founded in 2017, the company focuses on creating reactors capable of generating fuel cell quality hydrogen from ammonia, making them suitable for small-to-medium-scale applications and hydrogen refueling stations for fuel cell vehicles. Unlike conventional chemical reactors, Syzygy's technology operates using light as an energy source and at temperatures over 1,000°F lower, which significantly reduces maintenance costs and allows for rapid production start-stop capabilities. This innovative approach not only enhances efficiency but also supports the decarbonization of hard-to-abate industries by enabling the use of renewable electricity and minimizing reliance on fossil fuels.

Vaxess Technologies, Inc. is a biotechnology company based in Boston, Massachusetts, founded in 2011. The company focuses on developing and commercializing innovative silk biomaterial technologies. Its key product, the MIMIX microneedle platform, facilitates the transdermal delivery of vaccines and therapeutics. This sustained release patch technology allows for a controlled release of vaccines, mimicking the natural infection process to enhance immune response and effectiveness. Vaxess's patch is engineered for stability, eliminating the need for refrigeration, which enables shipping and application in low-resource settings. In addition to its vaccine delivery systems, Vaxess is also engaged in creating novel therapies aimed at oncology care and infectious diseases, ultimately striving to improve patient outcomes with reduced treatment burdens.

Axoft is a company focused on developing advanced implantable electronics that enhance communication between the brain and machines. Its flagship technology consists of bioinspired implants made from ultra-flexible plastic mesh, which provides a softer alternative to traditional plastic and silicone implants. This innovative design allows for scalability and the integration of multiple sensors within a single implant, closely matching the brain's mechanical properties. Axoft's implants aim to improve clinical outcomes for patients suffering from neurodegenerative conditions, such as Parkinson's disease, thereby transforming individual health and overall human experience.

Form Energy, Inc. specializes in the development of long-duration energy storage systems aimed at enhancing the reliability of renewable energy sources such as wind and solar. Founded in 2017 and based in Somerville, Massachusetts, the company focuses on creating low-cost battery systems, including its innovative iron-air battery technology, which allows for energy storage over extended periods. This capability enables the dispatch of renewable energy throughout the year, effectively replacing traditional fossil fuel-based generation and contributing to the decarbonization of the electric grid. Additionally, Form Energy offers Formware, a capacity expansion software tool designed to optimize energy management. The company's technological advancements are rooted in research from MIT and are supported by various investors committed to sustainable energy solutions.

Mantel is focused on developing innovative carbon capture technology aimed at reducing carbon dioxide emissions and achieving net-negative emissions. The company's method captures CO2 before it can enter the atmosphere, utilizing low energy processes to enhance efficiency. Designed for integration within boilers, kilns, and furnaces, Mantel's technology leverages biomass waste and residue to facilitate significant carbon removal. This approach addresses sustainability challenges while utilizing liquid-phase chemistry applicable across various sectors, including industrial heat, steel, and chemicals. By enabling clients to lower their costs associated with carbon capture and storage, Mantel plays a crucial role in the transition towards a more sustainable future.

Sync Computing Corp. is a developer and manufacturer of an optimization processing unit (OPU) that addresses complex combinatorial optimization problems across various industries, including telecommunications, pharmaceuticals, finance, and logistics. Founded in 2019 and based in Cambridge, Massachusetts, the company focuses on providing innovative optimization solutions that enhance efficiency and effectiveness in sectors that heavily rely on machine learning and data-driven decision-making. The OPU represents a unique approach by integrating optimization algorithms into hardware, allowing organizations to tackle significant societal challenges through advanced computational techniques.

Atlantic Quantum is a company focused on developing scalable quantum computers to address complex computational challenges. Founded in 2022, the company emphasizes the importance of fault-tolerant quantum hardware as essential for advancing the field of quantum computing. By creating reliable and efficient quantum systems, Atlantic Quantum aims to enable engineers and researchers to make significant strides in solving difficult problems that traditional computing methods struggle to address.

Foundation Alloy specializes in the development of advanced materials, focusing on the design of innovative alloys tailored for additive manufacturing. The company aims to create metal parts that promote environmentally sustainable manufacturing practices while reducing overall acquisition costs. By integrating proprietary alloy design technology with advanced manufacturing techniques and automation, Foundation Alloy enhances the performance and production efficiency of industrial applications. This approach allows front-line engineers to optimize the manufacturing process compared to traditional materials and methods.

Hyfé is a feedstock processing company focused on transforming food waste into valuable chemicals, materials, fuels, and foods through fungal fermentation. By upcycling waste generated in food manufacturing, Hyfé aims to create sustainable, cost-competitive products that benefit various industries. This innovative approach not only maximizes profits for food manufacturers but also helps reduce the carbon footprint of the food industry, promoting a more sustainable future. The company is dedicated to unlocking the full value of crops, allowing for the production of essential goods without reliance on petroleum.

Seaspire Skincare specializes in the development and manufacturing of multifunctional colorants and active ingredients derived from oceanic biodiversity. The company focuses on creating innovative solutions to address chronic and cosmetic hair and skin conditions while aiming to replace harmful components in traditional sunscreens. One of its key products features the biomolecule Xanthochrome, which provides enhanced protection against a wider spectrum of ultraviolet radiation compared to existing physical and chemical filters. This technology is designed for preventative skincare, promoting a healthier approach that minimizes adverse effects on both human and marine health. Through its sustainable and less toxic formulations, Seaspire Skincare contributes to advancing the skincare industry towards safer and environmentally friendly practices.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Quaise is an energy company based in Cambridge, Massachusetts, focused on developing innovative millimeter-wave drilling systems to access deep geothermal heat. Founded in 2018, the company aims to overcome geographic limitations that currently restrict the utilization of geothermal energy. By repurposing existing fossil-fuel industrial assets, Quaise's technology enables the drilling of geothermal wells directly at operational power plants, facilitating a smoother transition to cleaner energy sources. This approach allows mining companies to collectively generate terawatts of clean power, rivaling the output of fossil fuels while achieving zero carbon emissions.

Celestial AI is a prominent artificial intelligence company that provides an advanced platform for users to efficiently create images, text, and presentations. Utilizing computer vision algorithms and natural language processing, the platform produces high-quality visual and textual content. Its intuitive design and innovative features simplify the creation process, while intelligent data integration and a commitment to security ensure reliable results.

Resonant Link LLC, founded in 2017 and based in Shelburne, Vermont, specializes in the development of advanced wireless charging solutions utilizing innovative coil technology. The company's signature product, the multi-layer self-resonant structure (MSRS), enhances the efficiency and performance of wireless power systems. Serving diverse industries including robotics, drones, and electric vehicles, Resonant Link aims to deliver wireless power solutions that are fast, safe, and reliable. By eliminating costly components found in traditional wireless chargers, Resonant Link's technology not only improves efficiency but also reduces the size, weight, and overall cost of charging systems. This enables a wide range of applications, from large industrial vehicles to compact medical devices.

Sync Computing Corp. is a developer and manufacturer of an optimization processing unit (OPU) that addresses complex combinatorial optimization problems across various industries, including telecommunications, pharmaceuticals, finance, and logistics. Founded in 2019 and based in Cambridge, Massachusetts, the company focuses on providing innovative optimization solutions that enhance efficiency and effectiveness in sectors that heavily rely on machine learning and data-driven decision-making. The OPU represents a unique approach by integrating optimization algorithms into hardware, allowing organizations to tackle significant societal challenges through advanced computational techniques.

Cellino is focused on creating an automated biomanufacturing system for personalized cell therapies, with the aim of making these treatments widely accessible. The company leverages an AI-guided laser editing platform that employs image-guided machine learning and robotics to generate autologous induced pluripotent stem cells (iPSCs) at scale. This innovative approach is designed to facilitate the development of potentially curative therapies for chronic degenerative diseases, such as vision loss and Parkinson's disease. By streamlining the process of cell therapy production, Cellino aims to enhance the availability of life-saving medicines for patients around the world.

Commonwealth Fusion Systems LLC is a research and development company focused on advancing fusion energy technology to provide an inexhaustible power source. Established in 2017 and based in Cambridge, Massachusetts, the company utilizes rare-earth barium copper oxide superconductor technology to create fusion energy systems. Commonwealth Fusion Systems was spun out of the Massachusetts Institute of Technology (MIT) and collaborates with MIT’s Plasma Science and Fusion Center to leverage decades of government-funded fusion research. By integrating established physics with innovative magnet technology, the company aims to accelerate the commercialization of fusion energy, positioning itself as a key player in the transition to clean and renewable energy sources while addressing climate change challenges.

Osmoses specializes in clean membrane technology aimed at decarbonizing gas separations, with a goal of eliminating one gigaton of carbon emissions annually. The company has developed advanced molecular filters that offer exceptional size selectivity, enabling the purification of hydrogen and natural gas. Additionally, these filters facilitate large-scale carbon capture, significantly transforming traditional chemical separation processes. By reducing energy consumption and carbon emissions in industrial operations, Osmoses provides a solution that helps businesses lower costs, minimize product loss, and create value for their clients, contributing to broader efforts in combating climate change.

Hedron is focused on developing a network of data relay satellites that facilitate real-time communication between Earth and space. Their modular and scalable system employs a hybrid RF-optical communication approach, providing connectivity for low-Earth orbit satellites. Hedron's imaging satellites generate valuable data that address critical global challenges, including food and water security, climate change monitoring, and disaster mitigation. By offering a series of data relay nodes, the company enables clients to optimize the global economy and enhance understanding of the planet, paving the way for innovation and improved insights in various sectors.

Via Separations, Inc. is focused on developing innovative membrane-based products for industrial liquid separation in challenging environments. Founded in 2016 and based in Somerville, Massachusetts, the company aims to address the significant energy waste in the chemical separation process, which accounts for 12% of U.S. energy consumption. By employing its advanced membrane technology, Via Separations can reduce energy use by up to 90% and enhance product output. Their highly selective and robust membrane filters replace traditional heat-based separation methods, contributing to industrial decarbonization efforts. The company is currently conducting pilot trials in pulp and paper facilities, with the goal of eliminating 100 million metric tons of CO2 emissions by 2050. Originating from MIT's Department of Material Science & Engineering, Via Separations has successfully scaled its technology and demonstrated working prototypes at a commercial level.

Kytopen is a developer of a cell therapy platform that focuses on the non-viral delivery of molecules into challenging immune cells. The company's innovative technology integrates microfluidics and automation to streamline the delivery process, making it faster, easier, and more cost-effective. Kytopen's automated cell engineering platform enables researchers to produce healthy and functional engineered cells rapidly, maintaining their health and functionality. By combining continuous fluid flow with electric fields, Kytopen enhances the efficiency of payload delivery to primary cells, supporting advancements in biology and paving the way for innovative cell and gene therapies.

Lilac Solutions, Inc. is a mining technology company focused on lithium extraction, providing innovative technology and services to lithium producers. The company specializes in ion exchange beads and continuous brine processing systems, which enable the efficient production of high-purity lithium solutions from various brine resources. This technology, grounded in ion-exchange theory, allows lithium producers to enhance project development, improve lithium recovery rates, and optimize operational efficiency while also minimizing costs and environmental impact. Lilac Solutions serves industries such as electric vehicles and renewable energy storage. Incorporated in 2015, the company is headquartered in Oakland, California.

Form Energy, Inc. specializes in the development of long-duration energy storage systems aimed at enhancing the reliability of renewable energy sources such as wind and solar. Founded in 2017 and based in Somerville, Massachusetts, the company focuses on creating low-cost battery systems, including its innovative iron-air battery technology, which allows for energy storage over extended periods. This capability enables the dispatch of renewable energy throughout the year, effectively replacing traditional fossil fuel-based generation and contributing to the decarbonization of the electric grid. Additionally, Form Energy offers Formware, a capacity expansion software tool designed to optimize energy management. The company's technological advancements are rooted in research from MIT and are supported by various investors committed to sustainable energy solutions.

Emvolon is a technology company focused on developing a platform that facilitates the distributed production of chemicals from wasted resources, particularly natural gas at flare sites. By converting this wasted gas into usable chemicals, Emvolon addresses a variety of industrial applications and offers carbon-negative fuel alternatives. The company's innovative approach reimagines conventional diesel engines as miniature chemical reactors, allowing for efficient and localized chemical production. This method eliminates the need for large refineries and chemical plants, making it economically viable for smaller production facilities. Emvolon's technology aims to provide communities with the necessary raw materials while promoting sustainability and reducing waste.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Syzygy Plasmonics, Inc. is a Houston-based company that designs, develops, and manufactures photocatalytic reactor systems for industrial chemical reactions. Founded in 2017, the company focuses on creating reactors capable of generating fuel cell quality hydrogen from ammonia, making them suitable for small-to-medium-scale applications and hydrogen refueling stations for fuel cell vehicles. Unlike conventional chemical reactors, Syzygy's technology operates using light as an energy source and at temperatures over 1,000°F lower, which significantly reduces maintenance costs and allows for rapid production start-stop capabilities. This innovative approach not only enhances efficiency but also supports the decarbonization of hard-to-abate industries by enabling the use of renewable electricity and minimizing reliance on fossil fuels.

VEIR is focused on advancing electricity transmission through the development of high-temperature superconductors and innovative cooling solutions. The company has created a passive evaporative cryogenic cooling technology that significantly enhances cooling efficiency, delivering 20 times more cooling power per kilogram of nitrogen flow compared to traditional mechanical subcooling methods. By utilizing commercial superconducting tape, VEIR's technology facilitates power delivery at transmission levels over distribution-scale infrastructure without resistive losses. This approach allows clients to streamline permitting processes and create economically viable electric transmission lines, thereby addressing the challenges associated with cooling high-temperature superconductors.

Cellino is focused on creating an automated biomanufacturing system for personalized cell therapies, with the aim of making these treatments widely accessible. The company leverages an AI-guided laser editing platform that employs image-guided machine learning and robotics to generate autologous induced pluripotent stem cells (iPSCs) at scale. This innovative approach is designed to facilitate the development of potentially curative therapies for chronic degenerative diseases, such as vision loss and Parkinson's disease. By streamlining the process of cell therapy production, Cellino aims to enhance the availability of life-saving medicines for patients around the world.

Celestial AI is a machine learning accelerator company focused on developing an advanced optical interconnect technology platform for data centers and AI applications. By leveraging photonics, mixed-signal ASICs, and innovative packaging techniques, the company aims to enhance computing performance sustainably. Its proprietary Photonic FabricTM serves as the core technology for creating optically scalable and disaggregated data center computing and memory systems. This technology is designed to enable significant advancements in artificial intelligence, allowing clients to provide superior AI acceleration hardware and software solutions.

Boston Metal is a metallurgy company focused on reducing the carbon footprint of steel production through its innovative Molten Oxide Electrolysis (MOE) technology. Established in 2012 as a spin-off from MIT, the company has developed an industrial-scale solution that enables the efficient and cost-effective production of a diverse range of metals and alloys. Utilizing an electrolytic cell, Boston Metal processes raw iron ore to create ferroalloys, which are essential for producing various grades of steel. The company's advancements in MOE technology have resulted in a significant scaling of production capabilities, achieving a 1,000-fold increase and generating thousands of kilograms of metal. Headquartered in Woburn, Massachusetts, Boston Metal aims to provide a greener alternative for the metal industry by leveraging its unique process and a variety of feedstocks.

The Routing Company is a technology firm based in Cambridge, Massachusetts, specializing in dynamic vehicle routing and management solutions for public transit. Founded in 2018 by MIT researchers and rideshare industry veterans, the company offers a platform that utilizes proprietary artificial intelligence to optimize shared ride services. Its primary product, the Pingo™ app, allows users to request rides on-demand or in advance, accommodating various operational modes including flex, fixed, and paratransit. By partnering with cities and transit agencies, The Routing Company aims to enhance transport equity, accessibility, cost efficiency, and sustainability in urban mobility. The firm also provides fleet management tools and analytics to support private fleets and demand-responsive transit initiatives.

Zapata Computing, Inc. is a quantum software company that specializes in developing computing solutions for various industries, including finance, healthcare, logistics, and pharmaceuticals. Founded in 2017 and headquartered in Boston, Massachusetts, with an additional office in Toronto, the company offers Orquestra, a software platform that enables users to compose quantum workflows and execute them on both quantum and classical hardware. This platform facilitates simulations, optimizations, and machine learning applications, allowing for efficient management of complex tasks across different environments. As a spin-out from Harvard University, Zapata Computing leverages advanced computational techniques grounded in quantum physics to provide hardware-agnostic solutions tailored to enterprise organizations.

Form Energy, Inc. specializes in the development of long-duration energy storage systems aimed at enhancing the reliability of renewable energy sources such as wind and solar. Founded in 2017 and based in Somerville, Massachusetts, the company focuses on creating low-cost battery systems, including its innovative iron-air battery technology, which allows for energy storage over extended periods. This capability enables the dispatch of renewable energy throughout the year, effectively replacing traditional fossil fuel-based generation and contributing to the decarbonization of the electric grid. Additionally, Form Energy offers Formware, a capacity expansion software tool designed to optimize energy management. The company's technological advancements are rooted in research from MIT and are supported by various investors committed to sustainable energy solutions.

WoHo is a construction technology company founded in 2020 and based in Cambridge, Massachusetts. It offers an innovative approach to building by assembling teams, networks, and systems that enhance the construction of low to high-rise structures with exceptional quality, precision, and efficiency. WoHo's platform integrates architecture, engineering, and construction, providing clients with sustainable and economical solutions for creating both working and living spaces. By streamlining these processes, WoHo delivers competitive alternatives in the construction industry, focusing on a holistic and integrated methodology.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Quaise is an energy company based in Cambridge, Massachusetts, focused on developing innovative millimeter-wave drilling systems to access deep geothermal heat. Founded in 2018, the company aims to overcome geographic limitations that currently restrict the utilization of geothermal energy. By repurposing existing fossil-fuel industrial assets, Quaise's technology enables the drilling of geothermal wells directly at operational power plants, facilitating a smoother transition to cleaner energy sources. This approach allows mining companies to collectively generate terawatts of clean power, rivaling the output of fossil fuels while achieving zero carbon emissions.

Commonwealth Fusion Systems LLC is a research and development company focused on advancing fusion energy technology to provide an inexhaustible power source. Established in 2017 and based in Cambridge, Massachusetts, the company utilizes rare-earth barium copper oxide superconductor technology to create fusion energy systems. Commonwealth Fusion Systems was spun out of the Massachusetts Institute of Technology (MIT) and collaborates with MIT’s Plasma Science and Fusion Center to leverage decades of government-funded fusion research. By integrating established physics with innovative magnet technology, the company aims to accelerate the commercialization of fusion energy, positioning itself as a key player in the transition to clean and renewable energy sources while addressing climate change challenges.

Biobot Analytics, Inc. is a wastewater epidemiology company founded in 2017 and based in Cambridge, Massachusetts. The company has developed technology that transforms wastewater infrastructure into public health observatories by analyzing urine and stool samples. This technology provides health data that is independent of hospital reporting systems and is adaptable to emerging public health threats. Biobot Analytics offers a proprietary tool that measures health risks such as infectious disease outbreaks, antibiotic resistance, and drug consumption patterns, including its Opioid Consumption Monitoring Program, which estimates drug use in urban areas through sewage analysis. By generating anonymized public health data, Biobot delivers actionable insights to government officials, enabling them to prioritize interventions and address public health challenges effectively.

Rise Robotics, based in Somerville, Massachusetts, designs and manufactures innovative robotic components inspired by biological systems. Founded in 2011, the company aims to advance the robotics industry with a focus on creating powerful wearable ExoSUITS. Among its notable products is the Cyclone Muscle, a lightweight electric linear actuator that transforms rotary motion into linear force, enhancing performance in various applications by bridging the gap between force, speed, and control. Additionally, Rise Robotics developed the Bacon Robotic Air Compressor, which disrupts traditional handheld air compressors through the use of their Cyclone Linear Drive technology. This innovation supports a range of robotic functionalities, reflecting the company's commitment to empowering human capabilities through advanced robotics.

Lilac Solutions, Inc. is a mining technology company focused on lithium extraction, providing innovative technology and services to lithium producers. The company specializes in ion exchange beads and continuous brine processing systems, which enable the efficient production of high-purity lithium solutions from various brine resources. This technology, grounded in ion-exchange theory, allows lithium producers to enhance project development, improve lithium recovery rates, and optimize operational efficiency while also minimizing costs and environmental impact. Lilac Solutions serves industries such as electric vehicles and renewable energy storage. Incorporated in 2015, the company is headquartered in Oakland, California.

Seaspire Skincare specializes in the development and manufacturing of multifunctional colorants and active ingredients derived from oceanic biodiversity. The company focuses on creating innovative solutions to address chronic and cosmetic hair and skin conditions while aiming to replace harmful components in traditional sunscreens. One of its key products features the biomolecule Xanthochrome, which provides enhanced protection against a wider spectrum of ultraviolet radiation compared to existing physical and chemical filters. This technology is designed for preventative skincare, promoting a healthier approach that minimizes adverse effects on both human and marine health. Through its sustainable and less toxic formulations, Seaspire Skincare contributes to advancing the skincare industry towards safer and environmentally friendly practices.

Sync Computing Corp. is a developer and manufacturer of an optimization processing unit (OPU) that addresses complex combinatorial optimization problems across various industries, including telecommunications, pharmaceuticals, finance, and logistics. Founded in 2019 and based in Cambridge, Massachusetts, the company focuses on providing innovative optimization solutions that enhance efficiency and effectiveness in sectors that heavily rely on machine learning and data-driven decision-making. The OPU represents a unique approach by integrating optimization algorithms into hardware, allowing organizations to tackle significant societal challenges through advanced computational techniques.

ISEE, Inc. is an autonomous driving technology company based in Cambridge, Massachusetts, established in 2016. The company specializes in developing artificial intelligence-driven software and hardware solutions for self-driving vehicles, with a focus on modernizing the global supply chain. ISEE's autonomous yard trucks are utilized by major clients, including Maersk and various Fortune 100 retailers, to enhance the automation of logistics hubs. The company's proprietary technology excels at predicting human behavior and managing risk, allowing for improved safety, cost efficiency, and consistent performance in yard operations. By enabling seamless and safe operation of autonomous machines, ISEE aims to transform the logistics and supply chain industries.

E25Bio Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing rapid diagnostic tests for epidemic fever viruses, including dengue, chikungunya, and Zika. Founded in 2018, the company specializes in paper-based diagnostic systems that enable swift detection of viral antigens produced during infections. Its innovative platform allows for real-time data reporting through a mobile application, which captures results along with information on test timing and location. This approach aims to facilitate epidemiologic predictions and disease mapping, ultimately assisting governments and health organizations in managing outbreaks effectively and preventing public health crises. E25Bio's solutions are designed to provide affordable and timely diagnostics at the point of care.

Form Energy, Inc. specializes in the development of long-duration energy storage systems aimed at enhancing the reliability of renewable energy sources such as wind and solar. Founded in 2017 and based in Somerville, Massachusetts, the company focuses on creating low-cost battery systems, including its innovative iron-air battery technology, which allows for energy storage over extended periods. This capability enables the dispatch of renewable energy throughout the year, effectively replacing traditional fossil fuel-based generation and contributing to the decarbonization of the electric grid. Additionally, Form Energy offers Formware, a capacity expansion software tool designed to optimize energy management. The company's technological advancements are rooted in research from MIT and are supported by various investors committed to sustainable energy solutions.

Syzygy Plasmonics, Inc. is a Houston-based company that designs, develops, and manufactures photocatalytic reactor systems for industrial chemical reactions. Founded in 2017, the company focuses on creating reactors capable of generating fuel cell quality hydrogen from ammonia, making them suitable for small-to-medium-scale applications and hydrogen refueling stations for fuel cell vehicles. Unlike conventional chemical reactors, Syzygy's technology operates using light as an energy source and at temperatures over 1,000°F lower, which significantly reduces maintenance costs and allows for rapid production start-stop capabilities. This innovative approach not only enhances efficiency but also supports the decarbonization of hard-to-abate industries by enabling the use of renewable electricity and minimizing reliance on fossil fuels.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Lucy Therapeutics is a biotech company focused on developing innovative treatments for neurological diseases that originate from mitochondrial dysfunction. The company utilizes a unique approach to drug discovery by targeting early disease mechanisms, which holds potential for addressing a range of neurological disorders, including Parkinson's Disease and Alzheimer's Disease. In addition to its therapeutic efforts, Lucy Therapeutics is engaged in the development of proprietary small molecule therapies and diagnostic biomarkers aimed at enhancing the understanding and treatment of central nervous system conditions. By leveraging genetic technologies, the company aims to provide deeper insights into personalized medicine, thereby improving patient outcomes and enabling more precise healthcare interventions in the neurological field.

Vaxess Technologies, Inc. is a biotechnology company based in Boston, Massachusetts, founded in 2011. The company focuses on developing and commercializing innovative silk biomaterial technologies. Its key product, the MIMIX microneedle platform, facilitates the transdermal delivery of vaccines and therapeutics. This sustained release patch technology allows for a controlled release of vaccines, mimicking the natural infection process to enhance immune response and effectiveness. Vaxess's patch is engineered for stability, eliminating the need for refrigeration, which enables shipping and application in low-resource settings. In addition to its vaccine delivery systems, Vaxess is also engaged in creating novel therapies aimed at oncology care and infectious diseases, ultimately striving to improve patient outcomes with reduced treatment burdens.

Commonwealth Fusion Systems LLC is a research and development company focused on advancing fusion energy technology to provide an inexhaustible power source. Established in 2017 and based in Cambridge, Massachusetts, the company utilizes rare-earth barium copper oxide superconductor technology to create fusion energy systems. Commonwealth Fusion Systems was spun out of the Massachusetts Institute of Technology (MIT) and collaborates with MIT’s Plasma Science and Fusion Center to leverage decades of government-funded fusion research. By integrating established physics with innovative magnet technology, the company aims to accelerate the commercialization of fusion energy, positioning itself as a key player in the transition to clean and renewable energy sources while addressing climate change challenges.

Kytopen is a developer of a cell therapy platform that focuses on the non-viral delivery of molecules into challenging immune cells. The company's innovative technology integrates microfluidics and automation to streamline the delivery process, making it faster, easier, and more cost-effective. Kytopen's automated cell engineering platform enables researchers to produce healthy and functional engineered cells rapidly, maintaining their health and functionality. By combining continuous fluid flow with electric fields, Kytopen enhances the efficiency of payload delivery to primary cells, supporting advancements in biology and paving the way for innovative cell and gene therapies.

Zapata Computing, Inc. is a quantum software company that specializes in developing computing solutions for various industries, including finance, healthcare, logistics, and pharmaceuticals. Founded in 2017 and headquartered in Boston, Massachusetts, with an additional office in Toronto, the company offers Orquestra, a software platform that enables users to compose quantum workflows and execute them on both quantum and classical hardware. This platform facilitates simulations, optimizations, and machine learning applications, allowing for efficient management of complex tasks across different environments. As a spin-out from Harvard University, Zapata Computing leverages advanced computational techniques grounded in quantum physics to provide hardware-agnostic solutions tailored to enterprise organizations.

Cellino is focused on creating an automated biomanufacturing system for personalized cell therapies, with the aim of making these treatments widely accessible. The company leverages an AI-guided laser editing platform that employs image-guided machine learning and robotics to generate autologous induced pluripotent stem cells (iPSCs) at scale. This innovative approach is designed to facilitate the development of potentially curative therapies for chronic degenerative diseases, such as vision loss and Parkinson's disease. By streamlining the process of cell therapy production, Cellino aims to enhance the availability of life-saving medicines for patients around the world.

Via Separations, Inc. is focused on developing innovative membrane-based products for industrial liquid separation in challenging environments. Founded in 2016 and based in Somerville, Massachusetts, the company aims to address the significant energy waste in the chemical separation process, which accounts for 12% of U.S. energy consumption. By employing its advanced membrane technology, Via Separations can reduce energy use by up to 90% and enhance product output. Their highly selective and robust membrane filters replace traditional heat-based separation methods, contributing to industrial decarbonization efforts. The company is currently conducting pilot trials in pulp and paper facilities, with the goal of eliminating 100 million metric tons of CO2 emissions by 2050. Originating from MIT's Department of Material Science & Engineering, Via Separations has successfully scaled its technology and demonstrated working prototypes at a commercial level.

Boston Metal is a metallurgy company focused on reducing the carbon footprint of steel production through its innovative Molten Oxide Electrolysis (MOE) technology. Established in 2012 as a spin-off from MIT, the company has developed an industrial-scale solution that enables the efficient and cost-effective production of a diverse range of metals and alloys. Utilizing an electrolytic cell, Boston Metal processes raw iron ore to create ferroalloys, which are essential for producing various grades of steel. The company's advancements in MOE technology have resulted in a significant scaling of production capabilities, achieving a 1,000-fold increase and generating thousands of kilograms of metal. Headquartered in Woburn, Massachusetts, Boston Metal aims to provide a greener alternative for the metal industry by leveraging its unique process and a variety of feedstocks.

Radix Labs develops software designed for laboratories, enabling biologists to automate their lab processes and experimentation. The company seeks to be the operating system for laboratories, facilitating integration with existing on-premise hardware and ensuring compatibility with equipment from various manufacturers. Based in the United States, Radix Labs aims to streamline laboratory operations and enhance efficiency through innovative software solutions.

HyperLight specializes in thin-film lithium niobate photonic integrated circuit solutions, focusing on the development of integrated optical circuits that minimize signal loss. Their product offerings include chip-scale modulators and photonic chips tailored for data centers, datacom, and quantum computing applications. These advanced circuits facilitate the conversion of signals between electricity and light waves, achieving high performance standards that allow clients to operate efficiently at reduced power levels. HyperLight collaborates closely with customers throughout the entire process, from conceptualization and design to prototyping and volume production, ensuring tailored solutions that meet specific needs in the rapidly evolving field of photonics.

Form Energy, Inc. specializes in the development of long-duration energy storage systems aimed at enhancing the reliability of renewable energy sources such as wind and solar. Founded in 2017 and based in Somerville, Massachusetts, the company focuses on creating low-cost battery systems, including its innovative iron-air battery technology, which allows for energy storage over extended periods. This capability enables the dispatch of renewable energy throughout the year, effectively replacing traditional fossil fuel-based generation and contributing to the decarbonization of the electric grid. Additionally, Form Energy offers Formware, a capacity expansion software tool designed to optimize energy management. The company's technological advancements are rooted in research from MIT and are supported by various investors committed to sustainable energy solutions.

Zapata Computing, Inc. is a quantum software company that specializes in developing computing solutions for various industries, including finance, healthcare, logistics, and pharmaceuticals. Founded in 2017 and headquartered in Boston, Massachusetts, with an additional office in Toronto, the company offers Orquestra, a software platform that enables users to compose quantum workflows and execute them on both quantum and classical hardware. This platform facilitates simulations, optimizations, and machine learning applications, allowing for efficient management of complex tasks across different environments. As a spin-out from Harvard University, Zapata Computing leverages advanced computational techniques grounded in quantum physics to provide hardware-agnostic solutions tailored to enterprise organizations.

Finwave Semiconductor specializes in the development of advanced gallium nitride (GaN) transistors and integrated circuits (ICs) tailored for 5G communications and power conversion applications. The company utilizes a unique 3DGaN technology, specifically its differentiated fin field-effect transistor (FinFET) design, to enhance the performance of high-volume applications such as radio frequency front end (RFFE) systems for mobile devices. This innovative approach allows Finwave to create semiconductor materials with distinct properties, contributing to advancements in electronics and energy management.

Hedron is focused on developing a network of data relay satellites that facilitate real-time communication between Earth and space. Their modular and scalable system employs a hybrid RF-optical communication approach, providing connectivity for low-Earth orbit satellites. Hedron's imaging satellites generate valuable data that address critical global challenges, including food and water security, climate change monitoring, and disaster mitigation. By offering a series of data relay nodes, the company enables clients to optimize the global economy and enhance understanding of the planet, paving the way for innovation and improved insights in various sectors.

Suono Bio, Inc. is a biotechnology company based in Medford, Massachusetts, focused on developing innovative therapeutic products utilizing its proprietary delivery technology. Founded in 2016, the company specializes in the ultra-rapid, localized delivery of small molecules, biologics, nucleic acids, and gene therapies directly to the gastrointestinal tract, eliminating the need for encapsulation. Suono Bio aims to transform the treatment of challenging diseases, particularly those involving inflammatory-mediated conditions, by enabling efficient and effective delivery of therapeutics across various tissues. This technology has the potential to enhance patient recovery from gastrointestinal diseases by ensuring that treatments reach their intended targets quickly and effectively.

Kytopen is a developer of a cell therapy platform that focuses on the non-viral delivery of molecules into challenging immune cells. The company's innovative technology integrates microfluidics and automation to streamline the delivery process, making it faster, easier, and more cost-effective. Kytopen's automated cell engineering platform enables researchers to produce healthy and functional engineered cells rapidly, maintaining their health and functionality. By combining continuous fluid flow with electric fields, Kytopen enhances the efficiency of payload delivery to primary cells, supporting advancements in biology and paving the way for innovative cell and gene therapies.

Via Separations, Inc. is focused on developing innovative membrane-based products for industrial liquid separation in challenging environments. Founded in 2016 and based in Somerville, Massachusetts, the company aims to address the significant energy waste in the chemical separation process, which accounts for 12% of U.S. energy consumption. By employing its advanced membrane technology, Via Separations can reduce energy use by up to 90% and enhance product output. Their highly selective and robust membrane filters replace traditional heat-based separation methods, contributing to industrial decarbonization efforts. The company is currently conducting pilot trials in pulp and paper facilities, with the goal of eliminating 100 million metric tons of CO2 emissions by 2050. Originating from MIT's Department of Material Science & Engineering, Via Separations has successfully scaled its technology and demonstrated working prototypes at a commercial level.

Baseload Renewables develops low-cost energy storage to replace fossil base-load generation with renewable energy.

C2Sense, Inc. specializes in developing chemiresistive gas sensors and miniaturized sensing technologies aimed at enhancing food quality and safety, particularly in the food and agriculture sectors. Founded in 2013 and based in Cambridge, Massachusetts, the company’s sensors detect gases like ethylene and biogenic amines at low concentrations, allowing stakeholders throughout the supply chain—from growers to consumers—to monitor the freshness of fruits, meats, and other perishable goods, ultimately reducing waste. C2Sense is also advancing its Halo Diagnostics product, a digitally connected immunoassay reader that offers near-PCR sensitivity and facilitates real-time test results through a cloud-based, HIPAA-compliant platform. This technology supports remote healthcare by enabling physicians to access patient test results instantly. Additionally, C2Sense has developed versatile sensing solutions that provide product quality information and counterfeit detection, using safe molecular additives that report on the status of goods throughout the distribution process, thereby enhancing security in various sectors, including pharmaceuticals and luxury goods.

ISEE, Inc. is an autonomous driving technology company based in Cambridge, Massachusetts, established in 2016. The company specializes in developing artificial intelligence-driven software and hardware solutions for self-driving vehicles, with a focus on modernizing the global supply chain. ISEE's autonomous yard trucks are utilized by major clients, including Maersk and various Fortune 100 retailers, to enhance the automation of logistics hubs. The company's proprietary technology excels at predicting human behavior and managing risk, allowing for improved safety, cost efficiency, and consistent performance in yard operations. By enabling seamless and safe operation of autonomous machines, ISEE aims to transform the logistics and supply chain industries.