Elm Street Ventures
Elm Street Ventures is a venture capital firm based in New Haven, Connecticut, that specializes in early-stage investments in life sciences and technology. The firm primarily invests in companies founded on intellectual property developed at Yale University and other regional research institutions, spanning from New York City to Southern New England. In the life sciences sector, Elm Street Ventures focuses on areas such as therapeutics, medical devices, diagnostics, and healthcare services. In technology, the firm targets investments in software, clean technology, and information technology. While it prefers to invest locally, this is not a strict requirement. Elm Street Ventures typically makes initial investments ranging from several hundred thousand dollars to over $1 million, often participating in syndicates with other institutional investors. The firm collaborates with experienced entrepreneurs and corporate managers, who may take on leadership roles in the companies it forms or invests in, while also welcoming proposals from entrepreneurs, scientists, and engineers seeking to establish new ventures.
Cybrexa, Inc. develops DNA repair inhibitors for radio- and chemo-sensitizers in cancer therapeutics. The product consists of peptide-based technology that directly targets tumor microenvironment. Cybrexa, Inc. was formerly known as Cybrexa, Inc. The company was founded in 2016 and is based in New Haven, Connecticut.
Artizan Biosciences develops small molecule drugs targeting human diseases, utilizing its IgA-SEQ technology platform to identify disease-driving bacteria within the intestinal microbiota. Founded in 2016 and headquartered in New Haven, Connecticut, the company focuses on creating new and potentially curative treatments. With a commitment to advancing pharmaceutical drug development, Artizan Biosciences aims to address unmet medical needs through innovative approaches in biotechnology.
P2 Science, Inc. is a bio-renewable chemistry company based in Woodbridge, Connecticut, that specializes in the development and production of specialty chemicals derived from renewable feedstocks, such as vegetable oils. Founded in 2009 by a team that includes Yale scientists and industry experts, P2 Science focuses on creating high-value ingredients for various sectors, including flavors and fragrances, cosmetics, household and industrial cleaning, personal care, and agriculture. The company has developed innovative processes that allow for the production of vegetable-derived versions of fragrance ingredients traditionally sourced from petrochemicals. This shift towards renewable alternatives addresses the growing demand among major manufacturers to replace petrochemical ingredients with sustainable options. P2 Science operates a laboratory in New Haven, Connecticut, to advance its technology and collaborates with key partners throughout the supply chain to facilitate the commercialization of its products.
EvolveImmune Therapeutics transforms the discovery and development of novel immunotherapies. By leveraging its proprietary in vivo target discovery platform, EvolveImmune is building a pipeline of novel therapeutic candidates against numerous targets that are expressed on multiple immune cell types. The company’s platform will generate first-in-class treatments for unmet needs in oncology and autoimmune diseases.
Artizan Biosciences develops small molecule drugs targeting human diseases, utilizing its IgA-SEQ technology platform to identify disease-driving bacteria within the intestinal microbiota. Founded in 2016 and headquartered in New Haven, Connecticut, the company focuses on creating new and potentially curative treatments. With a commitment to advancing pharmaceutical drug development, Artizan Biosciences aims to address unmet medical needs through innovative approaches in biotechnology.
Halda Therapeutics
Series A in 2019
Halda Therapeutics is a research-stage drug discovery company, seeking to create the next generation of precision medicine based on a novel therapeutic modality which may be a platform for a number of disease states.
Saphlux, Inc. develops, produces, and commercializes semi-polar gallium nitride (GaN) materials that solve droop and green gap problems in LEDs and lasers. The company offers semi-polar GaN templates in two diameters or customized size (quarters). Saphlux, Inc. was founded in 2014 and is based in New Haven, Connecticut.
P2 Science, Inc. is a bio-renewable chemistry company based in Woodbridge, Connecticut, that specializes in the development and production of specialty chemicals derived from renewable feedstocks, such as vegetable oils. Founded in 2009 by a team that includes Yale scientists and industry experts, P2 Science focuses on creating high-value ingredients for various sectors, including flavors and fragrances, cosmetics, household and industrial cleaning, personal care, and agriculture. The company has developed innovative processes that allow for the production of vegetable-derived versions of fragrance ingredients traditionally sourced from petrochemicals. This shift towards renewable alternatives addresses the growing demand among major manufacturers to replace petrochemical ingredients with sustainable options. P2 Science operates a laboratory in New Haven, Connecticut, to advance its technology and collaborates with key partners throughout the supply chain to facilitate the commercialization of its products.
SeeClickFix, Inc. is a communications platform designed to facilitate reporting of non-emergency issues by citizens and to enable governments to manage and respond effectively. Founded in 2007 and headquartered in New Haven, Connecticut, the company provides several tools aimed at enhancing civic engagement and government transparency. Its offerings include Request Management for gathering data and tracking work orders, Work Management for optimizing internal communication and assignments, and Citizen Engagement tools to inform and involve local communities. Additionally, SeeClickFix provides analytics tools that help assess public service performance and guide decision-making. The platform caters to various sizes and budgets, empowering residents, community organizations, and government officials to collaboratively enhance their neighborhoods. SeeClickFix operates as a subsidiary of CivicPlus, LLC.
P2 Science, Inc. is a bio-renewable chemistry company based in Woodbridge, Connecticut, that specializes in the development and production of specialty chemicals derived from renewable feedstocks, such as vegetable oils. Founded in 2009 by a team that includes Yale scientists and industry experts, P2 Science focuses on creating high-value ingredients for various sectors, including flavors and fragrances, cosmetics, household and industrial cleaning, personal care, and agriculture. The company has developed innovative processes that allow for the production of vegetable-derived versions of fragrance ingredients traditionally sourced from petrochemicals. This shift towards renewable alternatives addresses the growing demand among major manufacturers to replace petrochemical ingredients with sustainable options. P2 Science operates a laboratory in New Haven, Connecticut, to advance its technology and collaborates with key partners throughout the supply chain to facilitate the commercialization of its products.
Arvinas is a pharmaceutical company that focuses on developing novel therapeutics to treat a variety of diseases including cancer, pro-inflammatory, autoimmune and rare diseases. Its proprietary approach is the targeting of disease-causing proteins for degradation thus eliminating them from the body.
The company was founded in 2013 and is headquartered in Connecticut, United States.
P2 Science, Inc. is a bio-renewable chemistry company based in Woodbridge, Connecticut, that specializes in the development and production of specialty chemicals derived from renewable feedstocks, such as vegetable oils. Founded in 2009 by a team that includes Yale scientists and industry experts, P2 Science focuses on creating high-value ingredients for various sectors, including flavors and fragrances, cosmetics, household and industrial cleaning, personal care, and agriculture. The company has developed innovative processes that allow for the production of vegetable-derived versions of fragrance ingredients traditionally sourced from petrochemicals. This shift towards renewable alternatives addresses the growing demand among major manufacturers to replace petrochemical ingredients with sustainable options. P2 Science operates a laboratory in New Haven, Connecticut, to advance its technology and collaborates with key partners throughout the supply chain to facilitate the commercialization of its products.
Accelerated Orthopedic Technologies, Inc. provides instruments to treat articular cartilage defects with custom sizes, shapes, and matching topography. The company was formerly known as Advanced Orthopedic Technologies, Inc. and changed its name to Accelerated Orthopedic Technologies, Inc. in February 2010. Accelerated Orthopedic Technologies, Inc. was incorporated in 2009 and is based in Guilford, Connecticut.
Metagenomix
Seed Round in 2010
Metagenomix is an early-stage biotechnology company developing novel methods of screening microbes for pharmacologically active compounds. Among the indications under investigation are cancer, inflammation and infectious diseases including fungal infections and malaria. The technology also has applications in agriculture.
Kolltan Pharmaceuticals, Inc., is a private company founded in 2007 that is developing novel monoclonal antibody (mAb) drugs targeting receptor tyrosine kinases (RTKs). Kolltan's primary targets derive from seminal discoveries made in the laboratory of Dr. Joseph Schlessinger, Chairman of the Department of Pharmacology at the Yale School of Medicine, and in Kolltan’s laboratories.
Dr. Schlessinger's laboratory has characterized a novel molecular mechanism underlying activation of RTKs providing, for the first time, a clear molecular explanation — at atomic resolution — for the oncogenic activity of mutations that have been identified in a variety of human cancers.
Retail Optimization Inc. provides predictive macro optimization analytics to determine the most profitable levels of product selection, category space and inventory investment while enhancing the shopping experience for consumers.
Affomix is a biotechnology company specializing in the development of antibody-based products. Utilizing proprietary technology, it offers rapid and automated high-throughput selection of human monoclonal antibodies (mAbs). The company focuses on commercializing its mAbs, along with mAb microarrays and mAb libraries, for various applications in research, drug discovery, diagnostics, and therapeutics. Affomix aims to enhance the sensitivity and accuracy in measuring large numbers of proteins in biological samples, leveraging its capabilities to produce and screen antibodies against virtually all human proteins, including those that are post-translationally modified.
BioRelix, Inc., a biopharmaceutical company, engages in the discovery and development of anti-biotic drug candidates for the treatment of infectious diseases in the United States. It develops a portfolio of riboswitch-based therapeutic agents to overcome the lethal and devastating causes of bacterial infections. The company was founded in 2005 and is based in New Haven, Connecticut.