Shape Memory Medical
Series C in 2024
Shape Memory Medical Inc is a medical device company located in Santa Clara, California, focused on creating innovative therapeutic solutions for the peripheral vascular, cardiovascular, and neurovascular markets. The company specializes in utilizing Shape Memory Polymer (SMP) technology, which was originally developed at Texas A&M University and Lawrence Livermore National Laboratory. Shape Memory Medical is notable for being the first to introduce an FDA-cleared medical device incorporating SMP technology specifically for the vascular market, thereby enhancing the capabilities of physicians in patient care. The team at Shape Memory Medical possesses significant expertise in SMP foam technology and the commercialization of medical devices, positioning the company as a leader in its field.
Fractyl Health
Series F in 2022
Fractyl Health Inc. is a medical technology company dedicated to developing innovative solutions for the treatment of metabolic diseases, particularly type 2 diabetes and obesity. The company specializes in a minimally invasive procedure known as Revita DMR, or duodenal mucosal resurfacing therapy, which rejuvenates the lining of the duodenum through hydrothermal ablation. This approach aims to remove excessive layers of the duodenal mucosa that accumulate due to unhealthy diets, thereby addressing the root causes of metabolic disorders. Founded in 2010 and based in Lexington, Massachusetts, Fractyl Health seeks to redefine the treatment landscape from chronic management to durable, disease-modifying therapies, ultimately enhancing patient health and reducing the burden on healthcare systems.
Standard Bariatrics
Series B in 2021
Standard Bariatrics is a medical device company based in Cincinnati, Ohio, specializing in the development of surgical instruments for weight-loss surgeries, particularly laparoscopic sleeve gastrectomy. Founded in 2014, the company has created a series of disposable surgical tools designed to work alongside general-use endoscopic staplers. These innovative tools help surgeons standardize their techniques, reduce variability, and minimize waste during procedures. By decreasing the number of cartridges needed for each surgery, Standard Bariatrics enables healthcare providers to lower costs while ensuring consistent surgical outcomes.
Arterys Inc. is a pioneering company in the field of medical imaging analytics, focused on transforming healthcare through advanced radiology solutions. Established in 2007 and headquartered in San Francisco, California, with additional offices in Calgary, Canada, and Paris, France, Arterys offers a web-based, AI-powered platform that is FDA-cleared and designed to enhance patient care. Its suite of products includes Cardio AI for cardiac magnetic resonance image analysis, Lung AI for lung imaging, Liver AI for liver imaging, and Chest/MSK AI, which automates the detection of various conditions such as fractures and pulmonary nodules. Additionally, the Arterys PHI Service allows physicians to access patient data remotely. The platform's innovative technology enables radiologists to visualize and quantify blood flow in the human body, facilitating improved diagnostic capabilities and clinical decision-making.
EBR Systems
Venture Round in 2019
EBR Systems, Inc., established in 2003 and based in Sunnyvale, California, specializes in developing implantable systems for wireless tissue stimulation. The company focuses on treating cardiac arrhythmias by creating devices that improve heart function through wireless cardiac stimulation. Its flagship product is the Wise CRT System, which employs proprietary wireless technology to deliver pacing stimulation directly inside the left ventricle of the heart, enhancing its pumping efficiency and synchronizing rhythms.
Standard Bariatrics
Series A in 2018
Standard Bariatrics is a medical device company based in Cincinnati, Ohio, specializing in the development of surgical instruments for weight-loss surgeries, particularly laparoscopic sleeve gastrectomy. Founded in 2014, the company has created a series of disposable surgical tools designed to work alongside general-use endoscopic staplers. These innovative tools help surgeons standardize their techniques, reduce variability, and minimize waste during procedures. By decreasing the number of cartridges needed for each surgery, Standard Bariatrics enables healthcare providers to lower costs while ensuring consistent surgical outcomes.
Fractyl Health
Series D in 2017
Fractyl Health Inc. is a medical technology company dedicated to developing innovative solutions for the treatment of metabolic diseases, particularly type 2 diabetes and obesity. The company specializes in a minimally invasive procedure known as Revita DMR, or duodenal mucosal resurfacing therapy, which rejuvenates the lining of the duodenum through hydrothermal ablation. This approach aims to remove excessive layers of the duodenal mucosa that accumulate due to unhealthy diets, thereby addressing the root causes of metabolic disorders. Founded in 2010 and based in Lexington, Massachusetts, Fractyl Health seeks to redefine the treatment landscape from chronic management to durable, disease-modifying therapies, ultimately enhancing patient health and reducing the burden on healthcare systems.
Arterys Inc. is a pioneering company in the field of medical imaging analytics, focused on transforming healthcare through advanced radiology solutions. Established in 2007 and headquartered in San Francisco, California, with additional offices in Calgary, Canada, and Paris, France, Arterys offers a web-based, AI-powered platform that is FDA-cleared and designed to enhance patient care. Its suite of products includes Cardio AI for cardiac magnetic resonance image analysis, Lung AI for lung imaging, Liver AI for liver imaging, and Chest/MSK AI, which automates the detection of various conditions such as fractures and pulmonary nodules. Additionally, the Arterys PHI Service allows physicians to access patient data remotely. The platform's innovative technology enables radiologists to visualize and quantify blood flow in the human body, facilitating improved diagnostic capabilities and clinical decision-making.
Shape Memory Medical
Series B in 2017
Shape Memory Medical Inc is a medical device company located in Santa Clara, California, focused on creating innovative therapeutic solutions for the peripheral vascular, cardiovascular, and neurovascular markets. The company specializes in utilizing Shape Memory Polymer (SMP) technology, which was originally developed at Texas A&M University and Lawrence Livermore National Laboratory. Shape Memory Medical is notable for being the first to introduce an FDA-cleared medical device incorporating SMP technology specifically for the vascular market, thereby enhancing the capabilities of physicians in patient care. The team at Shape Memory Medical possesses significant expertise in SMP foam technology and the commercialization of medical devices, positioning the company as a leader in its field.
ReThink Medical
Series A in 2017
ReThink Medical, Inc. is a medical device and digital health company based in San Francisco, California, founded in 2010. The company specializes in the development of wrist-worn monitoring devices designed to predict and prevent hospitalizations due to heart failure. Their flagship product, CorBand™, utilizes advanced algorithms and artificial intelligence to continuously monitor physiological indicators such as heart rate and fluid status. This technology enables early detection of worsening heart conditions, potentially weeks in advance of noticeable symptoms. By focusing on compliance and ease of use, ReThink Medical aims to provide proactive management of heart failure patients, improving their quality of life while reducing healthcare costs associated with emergency interventions. In 2020, ReThink Medical became a subsidiary of Terumo Corporation.
Relievant Medsystems
Series D in 2016
Relievant Medsystems, Inc. is a medical device company focused on developing innovative solutions for chronic axial low back pain. Founded in 2004 and headquartered in Minneapolis, Minnesota, with a development office in Sunnyvale, California, the company has created the Intracept System. This minimally invasive procedure specifically targets the basivertebral nerve, providing relief by blocking pain signal transmission. The Intracept System offers patients a low-risk therapy option aimed at alleviating chronic vertebrogenic low back pain.
Chrono Therapeutics
Series B in 2016
Chrono Therapeutics Inc. is a pharmaceutical company based in Hayward, California, focused on revolutionizing drug delivery and addiction management. Founded in 2003, the company specializes in the development of SmartStop, a digital nicotine replacement therapy that employs a wearable device to deliver programmable, transdermal drug therapy. This innovative system is designed to tailor the timing and dosage of nicotine while providing real-time behavioral support to help users manage addiction and smoking cessation effectively. Chrono Therapeutics aims to address the challenges associated with smoking addiction through its advanced technology, which seeks to achieve optimal clinical outcomes and improve the overall quality of life for users. The company's leadership team brings extensive experience in product development, research and development, and navigating regulatory pathways, positioning Chrono Therapeutics as a key player in the smoking cessation market.
Arterys Inc. is a pioneering company in the field of medical imaging analytics, focused on transforming healthcare through advanced radiology solutions. Established in 2007 and headquartered in San Francisco, California, with additional offices in Calgary, Canada, and Paris, France, Arterys offers a web-based, AI-powered platform that is FDA-cleared and designed to enhance patient care. Its suite of products includes Cardio AI for cardiac magnetic resonance image analysis, Lung AI for lung imaging, Liver AI for liver imaging, and Chest/MSK AI, which automates the detection of various conditions such as fractures and pulmonary nodules. Additionally, the Arterys PHI Service allows physicians to access patient data remotely. The platform's innovative technology enables radiologists to visualize and quantify blood flow in the human body, facilitating improved diagnostic capabilities and clinical decision-making.
Arterys Inc. is a pioneering company in the field of medical imaging analytics, focused on transforming healthcare through advanced radiology solutions. Established in 2007 and headquartered in San Francisco, California, with additional offices in Calgary, Canada, and Paris, France, Arterys offers a web-based, AI-powered platform that is FDA-cleared and designed to enhance patient care. Its suite of products includes Cardio AI for cardiac magnetic resonance image analysis, Lung AI for lung imaging, Liver AI for liver imaging, and Chest/MSK AI, which automates the detection of various conditions such as fractures and pulmonary nodules. Additionally, the Arterys PHI Service allows physicians to access patient data remotely. The platform's innovative technology enables radiologists to visualize and quantify blood flow in the human body, facilitating improved diagnostic capabilities and clinical decision-making.
Twelve manufactures medical devices. It was formerly known as Foundry Newco XII, Inc. The company was incorporated in 2009 and is based in Menlo Park, California.
EBR Systems
Venture Round in 2015
EBR Systems, Inc., established in 2003 and based in Sunnyvale, California, specializes in developing implantable systems for wireless tissue stimulation. The company focuses on treating cardiac arrhythmias by creating devices that improve heart function through wireless cardiac stimulation. Its flagship product is the Wise CRT System, which employs proprietary wireless technology to deliver pacing stimulation directly inside the left ventricle of the heart, enhancing its pumping efficiency and synchronizing rhythms.
Focal Therapeutics
Venture Round in 2014
Focal Therapeutics, Inc. is a medical device company based in Aliso Viejo, California, founded in 2007. The company specializes in the development, manufacturing, and marketing of the BioZorb tissue marker, an innovative, implantable bioabsorbable device designed to provide three-dimensional radiographic marking of soft tissue sites. Primarily aimed at breast cancer surgery, the BioZorb marker is placed by surgeons at the time of tissue removal, enhancing the identification of surgical sites for subsequent medical procedures and imaging. This device holds significant clinical utility for surgeons and radiation oncologists by aiding in treatment planning, patient positioning during radiation therapy, and long-term follow-up care. Focal Therapeutics operates with a leadership team experienced in the medical device sector, particularly in breast cancer care, and serves a targeted audience of healthcare professionals involved in the treatment of breast cancer patients. As of October 2018, Focal Therapeutics operates as a subsidiary of Hologic, Inc.
SinuSys Corporation, established in 2010 and headquartered in Palo Alto, California, specializes in designing and developing medical devices to enhance sinus health. Its flagship product, Vent-Os, is a sinus dilation system that facilitates access to the sinus space and dilates the maxillary sinus ostia for diagnostic and therapeutic procedures in adults. Additionally, SinuSys is developing Restora, a steroid-eluting spacer that provides mechanical support to healing tissues while releasing an anti-inflammatory steroid. The company focuses on creating simple, two-step interventional procedures to effectively resolve sinusitis symptoms, improving the overall health of patients.
Nanostim
Venture Round in 2013
NanoStim is an early-stage medical device company focused on developing a miniaturized, leadless cardiac pacemaker aimed at reducing complications associated with traditional pacemakers, which affect over 100,000 individuals annually. The company has assembled a highly skilled team of medical device engineers to advance this innovative technology, which is designed for direct implantation in a cardiac chamber without the need for leads. By offering a leadless pacing solution, NanoStim seeks to improve patient outcomes and enhance the safety and effectiveness of cardiac interventions.
Nanostim
Venture Round in 2012
NanoStim is an early-stage medical device company focused on developing a miniaturized, leadless cardiac pacemaker aimed at reducing complications associated with traditional pacemakers, which affect over 100,000 individuals annually. The company has assembled a highly skilled team of medical device engineers to advance this innovative technology, which is designed for direct implantation in a cardiac chamber without the need for leads. By offering a leadless pacing solution, NanoStim seeks to improve patient outcomes and enhance the safety and effectiveness of cardiac interventions.
Biomimedica
Series B in 2012
Biomimedica is a medical device company based in South San Francisco, California, dedicated to innovating joint repair solutions through its proprietary synthetic cartilage technology. Founded in 2007, the company specializes in developing synthetic cartilages designed to restore the surface of damaged joints, providing effective medical devices for joint repair. Its pioneering approaches aim to enhance patient outcomes and advance the field of orthopedic medicine.
Relievant Medsystems
Series D in 2012
Relievant Medsystems, Inc. is a medical device company focused on developing innovative solutions for chronic axial low back pain. Founded in 2004 and headquartered in Minneapolis, Minnesota, with a development office in Sunnyvale, California, the company has created the Intracept System. This minimally invasive procedure specifically targets the basivertebral nerve, providing relief by blocking pain signal transmission. The Intracept System offers patients a low-risk therapy option aimed at alleviating chronic vertebrogenic low back pain.
CytoPherx
Series C in 2012
CytoPherx (formerly Nephrion) clinical stage medical device company addressing inflammation-based diseases and conditions. The company’s products are custom configurations of a proprietary selective cytopheresis-based inflammation modulating system.
Crux Biomedical
Series C in 2011
Crux Biomedical, Inc. was founded in August 2004 by physicians Tom Fogarty and Frank Arko, who aimed to address the clinical limitations of existing vena cava filters. The company specializes in the development of the Crux VCF System, a preventive device designed to mitigate the risk of pulmonary embolisms. This innovative system effectively prevents blood clots from traveling to the lungs, making it particularly beneficial for patients who are at risk of pulmonary embolism but are unable to tolerate blood thinners. Through its focus on improving patient outcomes, Crux Biomedical addresses a critical need in the management of venous thromboembolism.
OncoHealth
Series A in 2011
OncoHealth is a company that specializes in the development of screening devices aimed at detecting and diagnosing cancer. Its innovative technology focuses on the creation of protein bio-markers specifically for the screening and diagnostics of cervical cancer and other cancers associated with the human papillomavirus (HPV). By providing advanced tools for medical professionals, OncoHealth enhances the ability to monitor, diagnose, and treat cancer, ultimately contributing to improved patient outcomes in oncology.
Cianna Medical
Series B in 2011
Cianna Medical, Inc. is a women's health company focused on developing innovative medical technologies for the treatment of early-stage breast cancer. Headquartered in Aliso Viejo, California, the company was incorporated in 2007 and is dedicated to enhancing breast conservation therapy (BCT) options for women diagnosed with breast cancer. Cianna Medical's notable products include SAVI SCOUT, a wire-free radar localization solution that assists in accurately locating breast tumors, and SAVI Brachy, which delivers targeted radiation to minimize damage to surrounding healthy tissue. Additionally, the company provides a surgical guidance system that utilizes real-time audible and visual indicators to improve precision during lumpectomy and excisional biopsy procedures. Through its advancements, Cianna Medical aims to increase access to effective treatment options for women facing breast cancer. As of November 2018, Cianna Medical operates as a subsidiary of Merit Medical Systems, Inc.
Sonoma Orthopedic Products
Series D in 2011
Sonoma Orthopedic Products is an orthopedic device company focused on designing, developing, and delivering proprietary orthopedic implants to address complex fractures. Utilizing the WaviBody technology platform, the company provides innovative surgical solutions that are minimally invasive, catering specifically to active patients. The firm specializes in fracture fixation devices that facilitate the repair of challenging bone geometries, enabling orthopedic surgeons to effectively restore function and return patients to their daily activities more rapidly. By prioritizing ease of use and efficacy in their products, Sonoma Orthopedic Products aims to enhance the recovery process for individuals with problematic fractures.
Incline Therapeutics
Series A in 2010
Incline Therapeutics is a privately-held specialty pharmaceutical company that concentrates on developing innovative pain management solutions for hospital settings. The company's primary focus is on IONSYS, a fentanyl iontophoretic transdermal system designed as a patient-controlled analgesia option for adult inpatients who require opioid pain relief following surgery. This system offers a compact and disposable approach, utilizing a needleless design for the short-term management of postoperative pain. Incline Therapeutics is backed by prominent life science venture capital firms and is guided by an experienced management team with considerable expertise in the pharmaceutical and medical device industries.
Reverse Medical
Series B in 2010
Reverse Medical is a commercial-stage medical device company dedicated to the development of innovative solutions for neurovascular disorders, particularly in the management of acute ischemic strokes. The company specializes in creating embolic protection systems designed to enhance the revascularization process for patients experiencing these critical conditions. By concentrating on endovascular treatment options, Reverse Medical aims to improve patient outcomes and streamline interventions for stroke care, positioning itself as a key player in the medical technology sector.
Intuity Medical
Series D in 2010
Intuity Medical, Inc. is a medical technology company specializing in blood glucose monitoring systems for diabetes management. Founded in 2002 and headquartered in Fremont, California, the company is known for its innovative POGO Automatic Blood Glucose Monitoring System. This system is the first FDA-cleared automatic, one-step blood glucose meter that integrates lancing, blood collection, and analysis into a single cartridge capable of performing ten tests. Intuity Medical aims to provide a convenient and discreet solution for patients who require regular blood glucose testing, enhancing their ability to manage their diabetes effectively. The company was previously known as Rosedale Medical, Inc. until it rebranded in June 2007.
Cyberheart
Debt Financing in 2009
CyberHeart, Inc. is a clinical development-stage company focused on creating a non-invasive robotic ablation treatment for cardiac arrhythmias, such as atrial fibrillation and ventricular tachycardia. Founded in 2003 and based in Mountain View, California, the company has developed the CyberHeart System, which utilizes advanced technology to dynamically detect, track, and compensate for the movement of the heart and patient during treatment. This ensures precision in the delivery of radiation. The CyberHeart System is intended for use by healthcare professionals, including radiation oncologists, medical physicists, electrophysiologists, and cardiac surgeons, to effectively treat these conditions without invasive procedures. CyberHeart operates as a subsidiary of Varian Medical Systems and has been conducting pre-clinical studies to validate the feasibility of its technology.
Relievant Medsystems
Series C in 2009
Relievant Medsystems, Inc. is a medical device company focused on developing innovative solutions for chronic axial low back pain. Founded in 2004 and headquartered in Minneapolis, Minnesota, with a development office in Sunnyvale, California, the company has created the Intracept System. This minimally invasive procedure specifically targets the basivertebral nerve, providing relief by blocking pain signal transmission. The Intracept System offers patients a low-risk therapy option aimed at alleviating chronic vertebrogenic low back pain.
Ardian, established in 1996, is a France-based asset manager offering global investment management services. It primarily focuses on fund of funds (55.21%), followed by direct funds (19.79%), infrastructure (16.67%), and private debt (7.29%), with a minor allocation to real estate (1.04%). Ardian invests across various sectors, including food value chain, healthcare, technology, and industrials, with a presence in Europe and North America.
Biomimedica
Series A in 2008
Biomimedica is a medical device company based in South San Francisco, California, dedicated to innovating joint repair solutions through its proprietary synthetic cartilage technology. Founded in 2007, the company specializes in developing synthetic cartilages designed to restore the surface of damaged joints, providing effective medical devices for joint repair. Its pioneering approaches aim to enhance patient outcomes and advance the field of orthopedic medicine.
Cyberheart
Series A in 2008
CyberHeart, Inc. is a clinical development-stage company focused on creating a non-invasive robotic ablation treatment for cardiac arrhythmias, such as atrial fibrillation and ventricular tachycardia. Founded in 2003 and based in Mountain View, California, the company has developed the CyberHeart System, which utilizes advanced technology to dynamically detect, track, and compensate for the movement of the heart and patient during treatment. This ensures precision in the delivery of radiation. The CyberHeart System is intended for use by healthcare professionals, including radiation oncologists, medical physicists, electrophysiologists, and cardiac surgeons, to effectively treat these conditions without invasive procedures. CyberHeart operates as a subsidiary of Varian Medical Systems and has been conducting pre-clinical studies to validate the feasibility of its technology.
HeartFlow
Seed Round in 2008
HeartFlow Inc., established in 2007 and headquartered in Redwood City, California, specializes in non-invasive coronary artery detection solutions. The company's flagship product, HeartFlow Analysis, employs artificial intelligence to generate a personalized 3D model of the heart using standard CT scan data. This enables clinicians worldwide to assess the impact of blockages on blood flow and determine optimal patient treatment, thereby reducing unnecessary invasive testing. HeartFlow operates additional offices in Portland (Oregon), Austin (Texas), London (UK), and Tokyo (Japan).