The Engine

Vaxess Technologies, Inc. is a biotechnology company based in Boston, Massachusetts, founded in 2011. The company specializes in the development and commercialization of silk biomaterial technologies, particularly the MIMIX microneedle platform, which facilitates transdermal delivery of vaccines and therapeutics. This innovative sustained release patch technology enhances vaccine administration by simulating a natural infection, promoting a robust and prolonged immune response, thereby improving vaccine effectiveness. Additionally, Vaxess’s MATRIX formulation and drying platform creates thermostable vaccines, therapeutics, and diagnostic products that do not require refrigeration, making them suitable for distribution in low-resource settings. Through these advanced solutions, Vaxess aims to improve patient outcomes in oncology care and infectious diseases while reducing treatment burdens for healthcare practitioners.

Vaxess Technologies, Inc. is a biotechnology company based in Boston, Massachusetts, founded in 2011. The company specializes in the development and commercialization of silk biomaterial technologies, particularly the MIMIX microneedle platform, which facilitates transdermal delivery of vaccines and therapeutics. This innovative sustained release patch technology enhances vaccine administration by simulating a natural infection, promoting a robust and prolonged immune response, thereby improving vaccine effectiveness. Additionally, Vaxess’s MATRIX formulation and drying platform creates thermostable vaccines, therapeutics, and diagnostic products that do not require refrigeration, making them suitable for distribution in low-resource settings. Through these advanced solutions, Vaxess aims to improve patient outcomes in oncology care and infectious diseases while reducing treatment burdens for healthcare practitioners.

Vaxess Technologies, Inc. is a biotechnology company based in Boston, Massachusetts, founded in 2011. The company specializes in the development and commercialization of silk biomaterial technologies, particularly the MIMIX microneedle platform, which facilitates transdermal delivery of vaccines and therapeutics. This innovative sustained release patch technology enhances vaccine administration by simulating a natural infection, promoting a robust and prolonged immune response, thereby improving vaccine effectiveness. Additionally, Vaxess’s MATRIX formulation and drying platform creates thermostable vaccines, therapeutics, and diagnostic products that do not require refrigeration, making them suitable for distribution in low-resource settings. Through these advanced solutions, Vaxess aims to improve patient outcomes in oncology care and infectious diseases while reducing treatment burdens for healthcare practitioners.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

Sync Computing Corp., established in 2019 and headquartered in Cambridge, Massachusetts, specializes in manufacturing Optimization Processing Units (OPUs). These units are designed to tackle combinatorial optimization problems across various sectors such as telecom, pharma, finance, logistics, and machine learning-dependent industries. Sync Computing's OPU is essentially an algorithm in hardware form, enabling organizations to efficiently solve complex optimization challenges.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Quaise is an energy company based in Cambridge, Massachusetts, focused on developing innovative millimeter-wave drilling systems to access deep geothermal energy resources worldwide. Founded in 2018, Quaise aims to overcome the geographic limitations that currently restrict geothermal energy utilization. The company's technology repurposes existing fossil-fuel industrial assets by drilling onsite at operational power plants, leveraging existing infrastructure and workforce to facilitate a smoother transition to clean energy. By enabling mining companies to harness this geothermal potential, Quaise aspires to generate terawatts of clean power that can compete with fossil fuels while producing zero carbon emissions.

Sync Computing Corp., established in 2019 and headquartered in Cambridge, Massachusetts, specializes in manufacturing Optimization Processing Units (OPUs). These units are designed to tackle combinatorial optimization problems across various sectors such as telecom, pharma, finance, logistics, and machine learning-dependent industries. Sync Computing's OPU is essentially an algorithm in hardware form, enabling organizations to efficiently solve complex optimization challenges.

Commonwealth Fusion Systems LLC is an energy research company based in Cambridge, Massachusetts, focused on developing fusion energy technology to address climate change. Established in 2017 as a spin-out from the Massachusetts Institute of Technology, the company utilizes rare-earth barium copper oxide superconductor technology to enhance fusion energy production. By integrating proven physics with advanced superconducting magnet technology, Commonwealth Fusion Systems aims to accelerate the commercialization of fusion energy. The company's efforts are directed toward designing and constructing fusion machines that promise limitless and clean energy, positioning them as a key player in the transition to renewable energy sources. Through collaboration with MIT's Plasma Science and Fusion Center, the company leverages decades of government-funded research to innovate within the private sector, ultimately contributing to the global pursuit of sustainable energy solutions.

Via Separations, Inc. is a company that specializes in developing membrane-based products for the separation of industrial liquids, aimed at enhancing efficiency in challenging industrial environments. Founded in 2016 and based in Somerville, Massachusetts, the company focuses on industrial decarbonization through innovative chemistries that significantly reduce energy consumption in manufacturing processes. Via's technology allows facilities to cut energy usage by 90% during chemical separation, replacing traditional heat-based methods with a highly selective and robust membrane filtration system. This advancement not only helps to minimize the environmental impact of industrial processes, but it also creates additional revenue opportunities for customers. Currently, Via is conducting pilot trials at pulp and paper facilities with the goal of eliminating 100 million metric tons of CO2 emissions by 2050. The company has successfully scaled its technology and demonstrated working prototypes at a commercial level, having emerged from MIT's Department of Material Science & Engineering.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Boston Metal, founded in 2012 as a spinout from MIT, is a metallurgy company headquartered in Woburn, MA. It specializes in developing technology to reduce the carbon footprint of steel production through its Molten Oxide Electrolysis (MOE) process. This industrial-scale solution enables efficient, lower-cost, and greener production of various metals and alloys from diverse feedstocks. Boston Metal has significantly scaled its technology and produced substantial quantities of metal since its inception.

The Routing Company, established in 2018 and headquartered in Cambridge, Massachusetts, specializes in developing advanced driver and rider applications for real-time shared ride routing. The company's core business involves providing private fleet management solutions, demand-responsive transit systems, analytics dashboards, and transit & paratransit services. Its flagship product, the Pingo™ app, facilitates on-demand or advance trip requests across various modes of operation, including on-demand, flex, fixed, and paratransit. The Routing Company partners with cities worldwide to enhance public transit efficiency, equity, accessibility, cost-effectiveness, and sustainability through its proprietary artificial intelligence-driven platform.

Zapata Computing, Inc. is a quantum software company that specializes in developing innovative computing solutions tailored for industrial and commercial applications. Founded in 2017 and headquartered in Boston, Massachusetts, with an additional office in Toronto, the company emerged from Harvard University and is driven by a team of scientists, including Alán Aspuru-Guzik. Zapata offers Orquestra, a software platform that enables the composition of quantum workflows using a YAML-compatible language, facilitating tasks across both quantum and classical hardware. Its solutions are hardware-agnostic and cater to various sectors, including finance, healthcare, pharmaceuticals, transportation, logistics, energy, and more. Equipped to address complex challenges, Zapata Computing focuses on simulation, optimization, and machine learning, helping enterprise organizations harness the power of quantum technology to enhance their operations.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

WoHo is a company based in Cambridge, Massachusetts, founded in 2020, that focuses on innovative construction systems and technology. It aims to revolutionize the building process by assembling teams, networks, and systems to create both low and high-rise structures with exceptional quality, precision, and efficiency. WoHo's platform integrates architecture, engineering, and construction, providing clients with sustainable and cost-effective solutions for various living and working spaces. By streamlining these processes, WoHo offers competitive alternatives in the construction industry, enhancing the overall efficiency of project delivery.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Quaise is an energy company based in Cambridge, Massachusetts, focused on developing innovative millimeter-wave drilling systems to access deep geothermal energy resources worldwide. Founded in 2018, Quaise aims to overcome the geographic limitations that currently restrict geothermal energy utilization. The company's technology repurposes existing fossil-fuel industrial assets by drilling onsite at operational power plants, leveraging existing infrastructure and workforce to facilitate a smoother transition to clean energy. By enabling mining companies to harness this geothermal potential, Quaise aspires to generate terawatts of clean power that can compete with fossil fuels while producing zero carbon emissions.

Commonwealth Fusion Systems LLC is an energy research company based in Cambridge, Massachusetts, focused on developing fusion energy technology to address climate change. Established in 2017 as a spin-out from the Massachusetts Institute of Technology, the company utilizes rare-earth barium copper oxide superconductor technology to enhance fusion energy production. By integrating proven physics with advanced superconducting magnet technology, Commonwealth Fusion Systems aims to accelerate the commercialization of fusion energy. The company's efforts are directed toward designing and constructing fusion machines that promise limitless and clean energy, positioning them as a key player in the transition to renewable energy sources. Through collaboration with MIT's Plasma Science and Fusion Center, the company leverages decades of government-funded research to innovate within the private sector, ultimately contributing to the global pursuit of sustainable energy solutions.

Biobot Analytics, Inc. is a wastewater epidemiology company based in Cambridge, Massachusetts, founded in 2017. It specializes in transforming wastewater infrastructure into public health observatories through innovative technology that analyzes sewage for health-related data. By deploying proprietary sampling devices and spatial analytics, Biobot measures various health threats, including infectious diseases, antibiotic resistance, and drug consumption patterns. The company's Opioid Consumption Monitoring Program specifically estimates opioid use in urban areas by analyzing wastewater. This approach generates anonymized public health data that is independent of traditional hospital reporting systems, allowing for rapid adaptability to emerging public health threats. Biobot Analytics offers its insights as a service, providing government officials with actionable data to prioritize interventions and address public health challenges effectively.

Sync Computing Corp., established in 2019 and headquartered in Cambridge, Massachusetts, specializes in manufacturing Optimization Processing Units (OPUs). These units are designed to tackle combinatorial optimization problems across various sectors such as telecom, pharma, finance, logistics, and machine learning-dependent industries. Sync Computing's OPU is essentially an algorithm in hardware form, enabling organizations to efficiently solve complex optimization challenges.

ISEE, Inc. is an autonomous driving technology company based in Cambridge, Massachusetts, established in 2016. The company specializes in developing artificial intelligence-based software and hardware solutions for self-driving vehicles, particularly focusing on automating logistics and supply chain operations. ISEE's innovative platform utilizes advanced AI to understand uncertainty, predict human behavior, and assess risk and efficiency, thereby enhancing the operational capabilities of autonomous machines. Its autonomous yard trucks are designed to improve safety, cost-effectiveness, and driving performance for major clients, including prominent companies in the retail and shipping industries. By leveraging its proprietary technology, ISEE aims to modernize supply chain logistics and contribute to seamless integration of autonomous systems in real-world applications.

E25Bio Inc. is a biotechnology company based in Cambridge, Massachusetts, founded in 2018, that focuses on developing rapid diagnostic tests for epidemic fever viruses. The company designs paper-based diagnostic systems and kits that facilitate the detection of viruses such as dengue, chikungunya, and Zika. E25Bio's innovative platform enables multiplexed testing that quickly identifies viral antigens during infections, allowing for real-time data reporting through a mobile application. This capability supports epidemiologic predictions and disease mapping, empowering governments and health organizations to respond effectively to outbreaks and manage public health crises. Through its commitment to fast, mobile testing solutions, E25Bio aims to prevent severe health outcomes associated with viral epidemics.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

Mori, formerly known as Overlook Research, is a company that develops a natural biopolymer coating designed to extend the shelf life of perishable foods. Founded in 2016 and headquartered in Boston, Massachusetts, Mori's innovative coating is made from proteins extracted from natural silk using salt and water. This protective layer helps slow the spoiling process of various food items, including fruits, vegetables, meat, and seafood, thereby reducing food waste. By focusing on sustainable and economical solutions, Mori aims to transform the food supply and enhance the efficiency of the food, agriculture, and packaging industries.

Commonwealth Fusion Systems LLC is an energy research company based in Cambridge, Massachusetts, focused on developing fusion energy technology to address climate change. Established in 2017 as a spin-out from the Massachusetts Institute of Technology, the company utilizes rare-earth barium copper oxide superconductor technology to enhance fusion energy production. By integrating proven physics with advanced superconducting magnet technology, Commonwealth Fusion Systems aims to accelerate the commercialization of fusion energy. The company's efforts are directed toward designing and constructing fusion machines that promise limitless and clean energy, positioning them as a key player in the transition to renewable energy sources. Through collaboration with MIT's Plasma Science and Fusion Center, the company leverages decades of government-funded research to innovate within the private sector, ultimately contributing to the global pursuit of sustainable energy solutions.

Vaxess Technologies, Inc. is a biotechnology company based in Boston, Massachusetts, founded in 2011. The company specializes in the development and commercialization of silk biomaterial technologies, particularly the MIMIX microneedle platform, which facilitates transdermal delivery of vaccines and therapeutics. This innovative sustained release patch technology enhances vaccine administration by simulating a natural infection, promoting a robust and prolonged immune response, thereby improving vaccine effectiveness. Additionally, Vaxess’s MATRIX formulation and drying platform creates thermostable vaccines, therapeutics, and diagnostic products that do not require refrigeration, making them suitable for distribution in low-resource settings. Through these advanced solutions, Vaxess aims to improve patient outcomes in oncology care and infectious diseases while reducing treatment burdens for healthcare practitioners.

Zapata Computing, Inc. is a quantum software company that specializes in developing innovative computing solutions tailored for industrial and commercial applications. Founded in 2017 and headquartered in Boston, Massachusetts, with an additional office in Toronto, the company emerged from Harvard University and is driven by a team of scientists, including Alán Aspuru-Guzik. Zapata offers Orquestra, a software platform that enables the composition of quantum workflows using a YAML-compatible language, facilitating tasks across both quantum and classical hardware. Its solutions are hardware-agnostic and cater to various sectors, including finance, healthcare, pharmaceuticals, transportation, logistics, energy, and more. Equipped to address complex challenges, Zapata Computing focuses on simulation, optimization, and machine learning, helping enterprise organizations harness the power of quantum technology to enhance their operations.

Via Separations, Inc. is a company that specializes in developing membrane-based products for the separation of industrial liquids, aimed at enhancing efficiency in challenging industrial environments. Founded in 2016 and based in Somerville, Massachusetts, the company focuses on industrial decarbonization through innovative chemistries that significantly reduce energy consumption in manufacturing processes. Via's technology allows facilities to cut energy usage by 90% during chemical separation, replacing traditional heat-based methods with a highly selective and robust membrane filtration system. This advancement not only helps to minimize the environmental impact of industrial processes, but it also creates additional revenue opportunities for customers. Currently, Via is conducting pilot trials at pulp and paper facilities with the goal of eliminating 100 million metric tons of CO2 emissions by 2050. The company has successfully scaled its technology and demonstrated working prototypes at a commercial level, having emerged from MIT's Department of Material Science & Engineering.

Boston Metal, founded in 2012 as a spinout from MIT, is a metallurgy company headquartered in Woburn, MA. It specializes in developing technology to reduce the carbon footprint of steel production through its Molten Oxide Electrolysis (MOE) process. This industrial-scale solution enables efficient, lower-cost, and greener production of various metals and alloys from diverse feedstocks. Boston Metal has significantly scaled its technology and produced substantial quantities of metal since its inception.

Form Energy, Inc. is a company focused on developing long-duration energy storage systems aimed at transforming the electric grid by enabling the reliable use of renewable energy sources such as wind and solar. Established in 2017 and based in Somerville, Massachusetts, Form Energy is known for its innovative iron-air battery technology, which allows for the storage of electricity over extended periods, making renewable energy more dispatchable throughout the year. This technology not only helps to replace conventional fossil fuel-based generation but also enhances transmission capacity without the need for new infrastructure. By facilitating deep decarbonization of the electric system, Form Energy plays a significant role in reducing carbon emissions and promoting a sustainable energy future.

Zapata Computing, Inc. is a quantum software company that specializes in developing innovative computing solutions tailored for industrial and commercial applications. Founded in 2017 and headquartered in Boston, Massachusetts, with an additional office in Toronto, the company emerged from Harvard University and is driven by a team of scientists, including Alán Aspuru-Guzik. Zapata offers Orquestra, a software platform that enables the composition of quantum workflows using a YAML-compatible language, facilitating tasks across both quantum and classical hardware. Its solutions are hardware-agnostic and cater to various sectors, including finance, healthcare, pharmaceuticals, transportation, logistics, energy, and more. Equipped to address complex challenges, Zapata Computing focuses on simulation, optimization, and machine learning, helping enterprise organizations harness the power of quantum technology to enhance their operations.

Suono Bio, Inc. is a biotechnology company based in Medford, Massachusetts, that focuses on designing and developing innovative therapeutic products with a unique delivery technology. Established in 2016, the company specializes in enabling ultra-rapid, localized delivery of small molecules, biologics, nucleic acids, and gene therapies directly to the gastrointestinal tract without the need for encapsulation. Suono Bio aims to transform the treatment landscape for difficult-to-treat diseases, particularly those mediated by inflammatory processes, by facilitating effective therapy delivery that enhances patient recovery from gastrointestinal conditions.

Via Separations, Inc. is a company that specializes in developing membrane-based products for the separation of industrial liquids, aimed at enhancing efficiency in challenging industrial environments. Founded in 2016 and based in Somerville, Massachusetts, the company focuses on industrial decarbonization through innovative chemistries that significantly reduce energy consumption in manufacturing processes. Via's technology allows facilities to cut energy usage by 90% during chemical separation, replacing traditional heat-based methods with a highly selective and robust membrane filtration system. This advancement not only helps to minimize the environmental impact of industrial processes, but it also creates additional revenue opportunities for customers. Currently, Via is conducting pilot trials at pulp and paper facilities with the goal of eliminating 100 million metric tons of CO2 emissions by 2050. The company has successfully scaled its technology and demonstrated working prototypes at a commercial level, having emerged from MIT's Department of Material Science & Engineering.

C2Sense, Inc., founded in 2013 and based in Cambridge, Massachusetts, specializes in developing chemiresistive gas sensors for applications in food and agriculture. Their sensors are designed to detect gases such as ethylene and biogenic amines at low concentrations, monitoring fruit ripeness and the freshness of meat, fish, and poultry throughout the supply chain. This technology helps improve food quality and reduce waste by enabling informed decisions at every stage from growers to consumers. Additionally, C2Sense is working on Halo Diagnostics, a digitally connected immunoassay reader that provides near-PCR sensitivity for patient-to-provider workflows. The company also offers sensing solutions for product quality information and counterfeit detection, using molecular additives that can be integrated into products or packaging to provide real-time status updates and detect issues during distribution.

ISEE, Inc. is an autonomous driving technology company based in Cambridge, Massachusetts, established in 2016. The company specializes in developing artificial intelligence-based software and hardware solutions for self-driving vehicles, particularly focusing on automating logistics and supply chain operations. ISEE's innovative platform utilizes advanced AI to understand uncertainty, predict human behavior, and assess risk and efficiency, thereby enhancing the operational capabilities of autonomous machines. Its autonomous yard trucks are designed to improve safety, cost-effectiveness, and driving performance for major clients, including prominent companies in the retail and shipping industries. By leveraging its proprietary technology, ISEE aims to modernize supply chain logistics and contribute to seamless integration of autonomous systems in real-world applications.