Evotec

Tubulis develops chemotherapeutic medications to combat cancer and chronic disorders. The company's chemotherapeutic medications are specifically matched protein-drug conjugates created by merging proprietary innovative technology with disease-specific biology, allowing clinicians to treat cancer patients without the risks associated with chemotherapy.

Centauri Therapeutics is a UK-based biotechnology company dedicated to discovering and developing innovative molecules aimed at combating life-threatening diseases. The company utilizes its proprietary Alphamer technology, which involves chemically synthesized molecules that redirect naturally occurring antibodies to specific pathogens, enhancing the immune response against infections. Each Alphamer consists of two components: one binds to a cell-surface target on the pathogen, while the other presents specific epitopes that engage circulating antibodies. This approach has demonstrated the ability to trigger an immediate antibacterial immune response, effectively clearing infections. Centauri Therapeutics' flexible Chemistry Platform allows for the synthesis of these bifunctional molecules, which are applicable in treating various infectious diseases. Additionally, the company has formed a joint venture, Avvinity Therapeutics, with Horizon Discovery to advance immuno-oncology initiatives, combining Centauri's expertise in Alphamer technology with Horizon's capabilities in gene editing and oncology. Through collaborations in aptamer selection, drug discovery, chemistry, and immunology, Centauri Therapeutics aims to enhance its impact in the field of immunotherapy.

IMIDomics is a unique company tackling Immune-Mediated Inflammatory Diseases (IMIDs). As an innovative leader in discovery and application of biomarkers and new targets to monitor and cure IMIDs, we create value through the combination of the world's largest IMID biobank, extensive relevant clinical expertise, high-throughput genomic and genetic analysis, and intellectual property. IMIDomics is located at Vall d'Hebron Hospital in Barcelona, Spain and on the HudsonAlpha Institute campus in Huntsville, Alabama.

Topas Therapeutics GmbH is a biotechnology company based in Hamburg, Germany, focused on developing nanoparticle-based therapeutics to address significant unmet medical needs, particularly in autoimmune diseases, allergies, and anti-drug antibodies. The company utilizes its proprietary Topas Particle Conjugates technology platform to induce antigen-specific immune tolerance by leveraging the liver's natural immunological processes. This approach targets liver sinusoidal endothelial cells to promote tolerance against blood-borne antigens. Topas is advancing several clinical-stage programs, with its lead candidate, TPM203, currently in clinical testing for pemphigus vulgaris, an orphan disease. Other therapeutic programs under development include treatments for celiac disease, Type 1 diabetes, and multiple sclerosis. The company has established research collaborations with Eli Lilly and Company and Boehringer Ingelheim to enhance its capabilities in antigen-specific tolerance induction and anti-drug antibodies, respectively. Topas Therapeutics was incorporated in 2013 and is dedicated to finding innovative solutions for chronic immunological conditions.

OXvax Ltd. is a spin-out company from the University of Oxford focused on the development of an advanced next-generation dendritic cell vaccine platform for the treatment of solid tumor cancers.

Exscientia combines human expertise with AI and machine learning to enhance drug discovery. The company focuses on precision engineering of medicine candidates, enabling faster and more efficient development of new treatments. By integrating innovative experimental techniques, Exscientia aims to improve patient outcomes and revolutionize the pharmaceutical industry.

Argobio is a start-up studio devoted to developing unique therapeutic solutions, with the purpose of nurturing and launching revolutionary biotech firms. It sources cutting-edge early-stage projects from leading European academic research institutes in order to cultivate and nurture these projects before launching companies. The main focus is on rare diseases, neurological issues, oncology, and immunology. Additionally, the studio is looking to create promising platform technologies for therapeutic products.

Blacksmith Medicines developing medicines targeting metal-dependent enzymes found in human physiology. Over 30% of known enzymes are metalloenzymes, covering all major enzyme classes: oxidoreductases, transferases, hydrolases, lyases, isomerases, and ligases. Metal ions, including magnesium, zinc, iron, manganese and copper, are the essential ingredient in these metalloenzymes.

Autobahn Labs is a biotechnology company that accelerates the development of novel therapeutics. It is a collaboration between a Samsara BioCapital-led investor syndicate and Evotec. By combining Samsara's long-term investment philosophy with Evotec’s world-class drug discovery and development capabilities, they believe they can improve patient health by identifying exciting early-stage academic research projects that can spark the development of new therapeutics. It was founded in 2018 and is based in Palo Alto, California.

Exscientia combines human expertise with AI and machine learning to enhance drug discovery. The company focuses on precision engineering of medicine candidates, enabling faster and more efficient development of new treatments. By integrating innovative experimental techniques, Exscientia aims to improve patient outcomes and revolutionize the pharmaceutical industry.

leon nanodrugs a specialised product development company dedicated to developing a pipeline of enhanced versions of existing drug products, and providing services to enable pre-clinical and clinical stage formulations for their clients NCEs or branded established drugs. leon-nanodrugs offers access to the next generation of nano-formulated drugs with meaningful differentiation and added patient benefits. They specialize in improving the bioavailability of poorly water soluble drugs by using leon’s proprietary MJR® Technology platform to create either polymeric or crystalline nanoparticles.

Immunitas is unlocking human immunology using novel single cell analyses to develop targeted therapeutics for patients with challenging, complex cancers. Translating findings from laboratory research to meaningful clinical advances in humans is a longstanding challenge in the oncology field. Immunitas was founded to directly address this problem and unlock a variety of novel drug targets based on discovery rooted in human biology. They are pursuing this goal with a team of pioneers in these areas across their scientific founders, management, and investors. At Immunitas, they employ a single cell sequencing platform to dissect the biology of immune cells in human tumors. Their focus on human samples allows us to start with and stay closer to the most relevant and translatable biology for patients and accelerates the pace of their research. They are identifying novel, exciting oncology targets and, importantly, developing key biomarkers to guide the selection of patients who may benefit from their new drugs. They are leveraging expertise in antibody discovery and engineering to create powerful therapies that modulate these targets, and are currently advancing a number of programs toward early human studies.

Aeovian Pharmaceuticals is a San Francisco-based biopharmaceutical company focused on the research and development of innovative therapeutics for rare and age-related diseases. Founded in 2012, the company aims to discover and commercialize compounds that modulate key molecular pathways, specifically targeting the mTORC1 and mTORC2 pathways. By addressing the underlying causes of disease initiation and progression—such as oxidative, cellular, and environmental stress—Aeovian Pharmaceuticals seeks to provide effective treatments that improve patient outcomes.

Breakpoint Therapeutics is a company that discover and develop new anti-cancer drugs. By targeting the DNA damage response (“DDR”) in cancer cells, Breakpoint Therapeutics aims to advance to clinical development first-in-class oncology drugs that interfere with DNA repair and replication stress tolerance pathways. Their mission is to develop drugs that succeed and complement PARP inhibitors and facilitate the cure of therapy resistant cancers.

Just Evotec Biologics was founded in 2014 and acquired by Evotec in 2019. The company has an intense focus on the design of innovative and integrated technologies to accelerate the development of biotherapeutics and reduce their manufacturing cost. Core strengths include antibody discovery, molecular design, process and product design and manufacturing plant design.

Celmatix is a next-generation women’s health company. They focus on reproductive health and fertility. Through their platform, they have amassed the largest structured dataset on ovarian health and outcomes in the world.

Exscientia combines human expertise with AI and machine learning to enhance drug discovery. The company focuses on precision engineering of medicine candidates, enabling faster and more efficient development of new treatments. By integrating innovative experimental techniques, Exscientia aims to improve patient outcomes and revolutionize the pharmaceutical industry.

Exscientia combines human expertise with AI and machine learning to enhance drug discovery. The company focuses on precision engineering of medicine candidates, enabling faster and more efficient development of new treatments. By integrating innovative experimental techniques, Exscientia aims to improve patient outcomes and revolutionize the pharmaceutical industry.

Aptuit, LLC provides the most complete set of integrated early discovery to mid-phase drug development services in the pharmaceutical industry including Drug Design & Discovery, API Development and Manufacture, Solid State Chemistry, CMC, Preclinical and IND enabling GLP/GMP programs. Fully integrated drug discovery & development services are available from their facilities in the UK, Italy, and now Switzerland. Aptuit, LLC is partnered with Welsh, Carson, and Anderson & Stowe, one of the world's leading private equity investors.

Forge Therapeutics, Inc is a biotechnology company discovering and developing novel therapeutics using an innovative chemistry platform targeting metalloproteins. Forge uses a proprietary approach combining bioinorganic (study of metals in biology) and medicinal chemistry to generate selective inhibitors of this large class of targets.

Eternygen is a Berlin based start up founded in June 2012 focusing on research and development of innovative drugs using a network of renowned scientists and contract research organizations. The main focus of Eternygen’s development and core competences of its founders are research and development of new drugs for dietary-related metabolic diseases with dramatically increasing prevalences in the last decades. Eternygen’s research addresses the sodium coupled citrate transporter NaCT which is a key regulator of lipid metabolism involved in the pathogenesis of fatty liver, diabetes and obesity. Company’s emphasis is the development of a safe and effective drug for treatment of these widespread diseases via targeted adjustment of underlying metabolic failure.

Cyprotex specialises in preclinical ADME Tox, both in vitro (laboratory experiments) and in silico (computer modelling). Cyprotex was founded in 1999, and in 2002 it was listed on the London Stock Exchange’s AIM Market (symbol CRX, information for investors). Our headquarters are in Macclesfield, UK, near Manchester.

Carrick Therapeutics is a developer of cancer therapeutics intended to transform the way cancer is treated. The company's therapeutics target molecular pathways that drive the most aggressive and resistant forms of cancer using innovative mechanisms, enabling cancer patients to get their predictive biomarkers detected and get their treatments started from early stage.

Aventis S.A. is a prominent global pharmaceutical company focused on the discovery, development, manufacture, and marketing of branded prescription drugs and human vaccines. The company is recognized for its significant contributions to preventative medicine, particularly through its vaccines division, which offers a comprehensive range of vaccines that protect against various infectious diseases. In 2008, this division provided over 1.6 billion doses, successfully immunizing more than 500 million people worldwide. Aventis aims to address health challenges by delivering innovative therapeutic solutions and is a leader in the pharmaceutical and vaccine industries.

Euprotec is a collaborative preclinical Contract Research Organisation.

Bionamics GmbH is an asset management company in Hamburg, Germany, bridging the gap between excellent research projects and the industry's need for pre-clinical and clinical development programmes.

Cell Culture Service GmbH (CCS), a Hamburg-based company which supports the cell culture needs of a world-wide customer base of biotech and Pharmaceutical companies. CCS is one of the leading suppliers of custom cells and cell-based reagents such as recombinant assay cell lines, assay-ready Frozen Instant Cells, qualified membranes, and proteins for high throughput screening with more than ten years experience in bulk cell production.

Compound Focus, Inc. offers molecule compound management services for liquid and solid compounds.

KINAXO Biotechnologies is a privately-held biotechnology company based in Munich/Martinsried, Germany. They are a service company specializing in chemical proteomics methods to support the successful development of small molecule drugs. As a spin-off of the Max Planck Institute of Biochemistry in Martinsried, they continuously expand and improve their technology platform in collaboration with the leading Max Planck laboratories of Axel Ullrich, Henrik Daub and Matthias Mann. KINAXO offers its clients extensive experience in cellular target profiling and other chemical proteomics applications.

Develogen is a biology-driven drug discovery company that is engaged in the development of therapies for diabetes and obesity. The company was founded in 1995 and is based in Georgia, United States.

Evotec (India) Private Limited provides drug discovery and development services for pharmaceutical, biotech, and fine chemical industries.

Renovis, Inc. is a biopharmaceutical company developing drugs to treat neurological diseases and disorders. The Company is currently developing products for acute ischemic stroke, for the treatment of neuropathic pain, and for the treatment of acute post-operative pain.

Evotec Neurosciences GmbH engages in the discovery and development of small molecule drugs.

Oxford Asymmetry International operates as an outsourcing arm for pharmaceutical companies.