Fifty Years

Fifty Years, established in 2016, is a San Francisco-based venture capital firm that invests in early-stage technology companies. It focuses on entrepreneurs using technology to address global challenges, with a particular interest in sectors such as healthcare, information technology, life science, and cleantech. Fifty Years aims to back companies that, if successful, will generate significant profits while contributing to the achievement of the United Nations' Sustainable Development Goals.

Seth Bannon

Founding Partner

Ela Madej

Co-Founder and Partner

Scott Phoenix

Partner

David Phoenix

Partner

Alex Teng

Partner

171 past transactions

Deepcell

Venture Round in 2025
Deepcell, Inc. is a biotechnology company based in Mountain View, California, that specializes in single-cell analysis technology. Founded in 2015, the company has developed an AI-powered imaging and microfluidics platform that offers a non-invasive method for genetic testing with diagnostic-level accuracy. This platform enables researchers to classify and isolate viable cells based on their morphological characteristics, thus facilitating improved diagnosis and treatment of diseases. By providing detailed genetic health information through ordinary blood samples, Deepcell aims to enhance translational research, diagnostic testing, and therapeutic applications, ultimately reducing the need for invasive procedures in medical diagnostics.

Gridware

Series A in 2025
Gridware is focused on enhancing and safeguarding the electrical grid, a critical infrastructure that, when compromised, can lead to severe consequences such as wildfires, property damage, and loss of life. The company has developed an advanced monitoring system that employs high-precision sensor arrays, including microphones and other sensing technologies, to continuously analyze the electrical and mechanical behavior of grid assets. This system incorporates an artificial intelligence processing unit that detects anomalies in the environment around power poles, enabling utilities to proactively address potential faults. By facilitating timely repairs and rapid responses to climatic anomalies, Gridware's technology improves safety, reliability, and reduces outage durations for utility companies. Headquartered in the Bay Area of Northern California, Gridware is privately held and supported by notable climate-tech and Silicon Valley investors, positioning itself to meet the growing demand for power while contributing to the future resilience of the electrical grid.

Aalo Atomics

Series A in 2024
Aalo Atomics is a clean energy company focused on developing and manufacturing small modular nuclear reactors (SMRs). These reactors are designed to be compact enough to fit in a garage yet powerful enough to supply electricity to various applications, from data centers to entire cities. The company aims to produce clean, affordable energy by commercializing high-technological readiness nuclear fission reactors, thereby reducing power consumption and promoting safety.

Waypoint Bio

Seed Round in 2024
Waypoint Bio is a biotechnology company focused on developing innovative cell therapy solutions aimed at treating solid tumors in cancer patients. The company leverages a proprietary platform that integrates spatial multi-omics, utilizing advanced artificial intelligence and machine learning techniques. This approach enhances the design of cell therapies and facilitates pooled screening methods, allowing for the creation of effective and safe treatment options. By optimizing cell therapy through the application of spatial biology, Waypoint Bio aims to improve outcomes for patients suffering from challenging cancer types.

BillionToOne

Series D in 2024
BillionToOne Inc. is a precision diagnostics company focused on developing advanced genetic testing platforms that detect and quantify diseases at the molecular level. Established in 2016 and headquartered in Menlo Park, California, the company offers a noninvasive prenatal screening solution called UNITY, which analyzes fetal cell-free DNA from a single blood sample provided by the mother. This test can identify single-gene disorders such as cystic fibrosis, spinal muscular atrophy, and thalassemia, thereby providing a safer alternative to invasive procedures like amniocentesis. Beyond prenatal diagnostics, BillionToOne is also developing oncology assays that enable the detection of actionable mutations and monitor tumor burden through blood samples, allowing for more precise therapy selection and monitoring. The company's innovative technologies aim to make genetic testing both accurate and accessible, ensuring that a broader spectrum of patients can benefit from advanced medical diagnostics.

The Bot Company

Seed Round in 2024
The Bot Company is a startup focused on developing AI-driven robotic platforms. Their mission is to create robots that help humans save time and increase efficiency. Currently, they are operating in stealth mode.

Nabla Bio

Series A in 2024
Nabla Bio is a biotechnology company that specializes in the development of an autoreverse platform for the discovery of innovative protein variants. These proteins, which exhibit unique qualities, are engineered to create new medicines and enhance nutritional products. By leveraging insights gained from billions of natural proteins, Nabla Bio enhances these variants through extensive experimentation, allowing for advanced applications in both medical and industrial fields. The company's focus on complex measurements of protein function positions it as a leader in the pursuit of previously unattainable protein capabilities.

Varda

Series B in 2024
Varda Space Industries, Inc. is a space manufacturing startup based in San Francisco, California, founded in 2020 by Delian Asparouhov and Trae Stephens. The company specializes in creating products in space that are intended for terrestrial applications, leveraging the unique advantages of low gravity. Varda aims to establish an infrastructure for harvesting materials from asteroids, enabling the production of new products in space. This approach not only facilitates the manufacturing of innovative goods but also promotes sustainability by reducing reliance on the destructive extraction of Earth's resources.

Cosmic Aerospace

Seed Round in 2024
Cosmic Aerospace is an innovative aerospace technology company focused on advancing sustainable aviation. The company specializes in the development of ultra-efficient all-electric passenger aircraft designed to achieve long flight ranges while minimizing environmental impact. By creating advanced propulsion systems and a unique airframe design, Cosmic Aerospace aims to reduce air pollution associated with regional flights, facilitating a transition to more energy-efficient air travel. Its commitment to sustainability positions it as a leader in the movement towards greener aviation solutions.

Planet A Foods

Series A in 2024
Planet A Foods is a producer of plant-based, cocoa-free chocolate that focuses on creating food products from natural ingredients. The company emphasizes local production to minimize the impact on land and resources while aiming to reduce global carbon emissions. By utilizing traditional fermentation techniques, Planet A Foods offers an alternative to conventional chocolate, allowing consumers to enjoy chocolate flavors without the associated environmental drawbacks of unsustainable cocoa production.

Faction

Seed Round in 2023
Faction specializes in the development of driverless electric vehicles that combine the speed and performance of cars with the affordability of motorcycles. The company focuses on micro-delivery and ride-on-demand services, utilizing a model that integrates remote human supervision alongside autonomous technology. This approach allows Faction to bypass the limitations of fully autonomous systems, enabling quicker deployment of its services. The vehicles are designed with networked data capabilities, over-the-air software updates, and safety-critical autonomy features, ensuring a cost-effective and reliable driverless solution for clients. After completing its first prototypes, Faction is set to commence trials to further refine its offerings in the transportation sector.

Elicit

Seed Round in 2023
Elicit is an artificial intelligence research assistant that uses language models to help users automate research workflows. This research assistant finds relevant papers without a perfect keyword match, summarizes takeaways from the papers, and extracts key information from the papers.

BIOS

Series A in 2023
BIOS Health is a pioneering company focused on developing neural digital therapies by harnessing data-driven insights from the human nervous system. Co-founded by researchers from Cambridge University, the firm aims to revolutionize precision medicine through the identification of neural biomarkers that link nerve activity to various medical conditions. BIOS's innovative approach holds promise for treating chronic diseases such as hypertension, diabetes, rheumatoid arthritis, and neurodegenerative disorders like Parkinson's and Alzheimer's. The company's expertise encompasses a diverse range of fields, including neuroscience, machine learning, software engineering, and biotechnology, allowing it to create advanced solutions for improving the quality of life for individuals suffering from these conditions. Additionally, BIOS is engaged in developing prosthetic connectors that standardize the interface between bionic devices and the body's nervous and soft-tissue systems, enabling enhanced control and feedback for patients with prosthetics.

Gridware

Seed Round in 2023
Gridware is focused on enhancing and safeguarding the electrical grid, a critical infrastructure that, when compromised, can lead to severe consequences such as wildfires, property damage, and loss of life. The company has developed an advanced monitoring system that employs high-precision sensor arrays, including microphones and other sensing technologies, to continuously analyze the electrical and mechanical behavior of grid assets. This system incorporates an artificial intelligence processing unit that detects anomalies in the environment around power poles, enabling utilities to proactively address potential faults. By facilitating timely repairs and rapid responses to climatic anomalies, Gridware's technology improves safety, reliability, and reduces outage durations for utility companies. Headquartered in the Bay Area of Northern California, Gridware is privately held and supported by notable climate-tech and Silicon Valley investors, positioning itself to meet the growing demand for power while contributing to the future resilience of the electrical grid.

Tangible

Seed Round in 2023
Tangible is a climate technology company focused on building sustainable materials that are not harmful to the environment. Tangible is a unified software platform that catalyzes the adoption of sustainable building materials by allowing real estate developers, architects, and contractors to seamlessly identify, manage, and report on products that meet their carbon, environmental, and social goals. Founded in 2021 by Nicole Granath and Anneli Tostar, Tangible is headquartered in San Francisco, California, United States.

MultiOmic Health

Seed Round in 2023
MultiOmic Health is a company focused on addressing metabolic syndrome-related diseases through AI-enabled drug discovery. It collaborates with healthcare providers to gather and analyze de-identified patient data and bio-samples. The company's MOHSAIC® platform integrates multi-omics analysis, computational systems biology modeling, and targeted laboratory experiments to develop novel precision therapeutic concepts. These concepts are then commercialized through partnerships with established biopharma companies.

Noya

Series A in 2023
Noya is a company focused on combating climate change through innovative carbon capture technology. By retrofitting existing industrial cooling towers, Noya integrates a non-toxic chemical blend that efficiently captures carbon dioxide without requiring physical alterations to the equipment. This approach allows industries to reduce their carbon footprints while simultaneously generating a valuable resource, as the captured CO2 is sold to companies that utilize it as a raw material. Noya's mission is to accelerate the global transition towards a carbon-negative future, positioning itself as a key player in the development of sustainable solutions for environmental challenges.

Aalo Atomics

Seed Round in 2023
Aalo Atomics is a clean energy company focused on developing and manufacturing small modular nuclear reactors (SMRs). These reactors are designed to be compact enough to fit in a garage yet powerful enough to supply electricity to various applications, from data centers to entire cities. The company aims to produce clean, affordable energy by commercializing high-technological readiness nuclear fission reactors, thereby reducing power consumption and promoting safety.

Mindset Health

Series A in 2023
Mindset Health is a digital therapeutics company based in Melbourne, Victoria, founded by Alex Naoumidis in 2018. The company develops an app-based hypnotherapy platform designed to help individuals manage chronic health issues, particularly irritable bowel syndrome, anxiety, and chronic pain. The platform offers a safe and nonaddictive alternative for treatment, allowing users to improve their conditions without the need for dietary changes. In addition to addressing irritable bowel syndrome, Mindset Health's solutions aim to enhance sleep quality and reduce stress, anxiety, and pain associated with various chronic conditions. Through its innovative approach, Mindset Health provides accessible and cost-effective healthcare options for those seeking relief from chronic health challenges.

Journey Clinical

Series A in 2023
Journey Clinical is a platform that provides services to member psychotherapy practices that are independently owned and operated, and in no way owns, directs, or controls the mental healthcare clinicians providing care.

Farcast

Venture Round in 2022
We build advanced satcom terminals

BillionToOne

Series C in 2022
BillionToOne Inc. is a precision diagnostics company focused on developing advanced genetic testing platforms that detect and quantify diseases at the molecular level. Established in 2016 and headquartered in Menlo Park, California, the company offers a noninvasive prenatal screening solution called UNITY, which analyzes fetal cell-free DNA from a single blood sample provided by the mother. This test can identify single-gene disorders such as cystic fibrosis, spinal muscular atrophy, and thalassemia, thereby providing a safer alternative to invasive procedures like amniocentesis. Beyond prenatal diagnostics, BillionToOne is also developing oncology assays that enable the detection of actionable mutations and monitor tumor burden through blood samples, allowing for more precise therapy selection and monitoring. The company's innovative technologies aim to make genetic testing both accurate and accessible, ensuring that a broader spectrum of patients can benefit from advanced medical diagnostics.

Solugen

Series D in 2022
Solugen, Inc. is a specialty chemicals company based in Houston, Texas, founded in 2016. It focuses on producing industrial chemicals through the application of biotechnology and green chemistry, specifically utilizing plant-derived substitutes to replace petroleum-based products. The company offers a range of products, including BioPeroxide, a carbon-negative hydrogen peroxide, and BioChelate, a biodegradable chelant. Other offerings include ScavSol, a multivalent metal sequestrant for energy applications, ScaleSol, an alternative to phosphonates for scale control, and CorrSol, which addresses corrosion and fouling. Solugen's innovative approach combines fermentation and petrochemical processing along with advancements in synthetic biology and enzymatic technology, enabling it to create environmentally friendly chemicals from bio-based feedstocks. Its solutions cater to diverse industries such as agriculture, cleaning, energy, and water, contributing to reduced costs and lower carbon emissions while promoting sustainability.

Molten Industries

Seed Round in 2022
Molten Industries is a clean technology company focused on decarbonizing the hydrogen market. It has developed innovative technology that produces hydrogen in a cost-effective and environmentally friendly manner. By providing an emissions-free method of hydrogen generation, Molten Industries enables chemical and heavy industries to significantly reduce their carbon footprint. The company's commitment to sustainable practices positions it as a key player in the transition towards cleaner energy solutions.

Harmonic Discovery

Seed Round in 2022
Harmonic Discovery is a pharmaceutical company focused on developing innovative solutions for cancer treatment through its advanced drug platform. This platform integrates biological screening, medicinal chemistry, and computational chemistry to create kinase inhibitors that address cancer resistance mechanisms. By employing structural modeling and machine learning, Harmonic Discovery predicts potential clinical resistance mutations and optimizes the design of small molecule therapeutics. This approach aims to maintain essential therapeutic targets while minimizing harmful off-target interactions, thereby enhancing the effectiveness of cancer treatments for medical practitioners.

Arpeggio Bio

Series A in 2022
Arpeggio Bio, established in 2017 and headquartered in Boulder, Colorado, specializes in developing innovative software that captures snapshots of cellular RNA activity. By combining biological assays with advanced machine learning algorithms, the company enables pharmaceutical and biotechnology firms to understand a drug's mechanism of action at low sequencing depths. Arpeggio Bio's technology reveals intricate biological networks, facilitating more informed therapeutic development.

Persephone Biosciences

Seed Round in 2022
Persephone Biome, Inc. is a San Diego-based company focused on researching and developing products and therapies that modify gut microbial metabolism, particularly in relation to cancer treatment. Established in 2017, the company is creating innovative solutions aimed at enhancing the efficacy of oncology drugs by retuning the gut microbiome. This includes the development of a pill containing beneficial gut bacteria. In addition to its therapeutics, Persephone Biome aims to offer nutritional products that support the human gut microbiome, producing functional foods and beverages that cater to the growing consumer demand for health-oriented products. The company has plans to enter clinical trials to further advance its initiatives in the field of microbiome-directed therapies.

resistanceBio

Seed Round in 2022
Solving cancer resistance.

Manifold Bio

Series A in 2022
Manifold Biotechnologies, Inc. is a biotechnology company that specializes in developing platforms for the pharmacological measurement of various therapeutic protein variants. By integrating DNA technologies with machine learning, the company aims to create protein drugs that address challenging diseases. Manifold Bio's innovative approach includes a protein barcoding platform designed to enable multiplexed quantitation of protein therapeutics, thereby generating extensive data that enhances the drug development process. Founded in 2019 and located in Allston, Massachusetts, the company is focused on advancing measurement-driven design in the field of protein therapeutics.

LatchBio

Series A in 2022
LatchBio is a biotechnology company founded in 2021 by Alfredo Andere, Kyle Giffin, and Kenny Workman. It focuses on developing a data infrastructure aimed at supporting the open-source biocomputing revolution. The company provides a bioinformatics platform specifically designed for cell and gene therapy startups, offering a modern cloud computing stack that enables biotech labs to manage and execute custom workflows, pipelines, and machine learning models. This platform allows scientists to create bioinformatic queries efficiently, without requiring command-line expertise or the burdens of complex system setups. By streamlining data integration and computational processes, LatchBio helps biotech companies accelerate therapeutic discovery and reduce engineering costs.

Boundary Layer Technologies

Seed Round in 2022
Boundary Layer Technologies is a startup established in 2018 that specializes in the development of high-speed container ships utilizing hydrofoil technology. This innovative approach allows the ships to generate lift, elevating the hull above the waterline and significantly reducing drag. As a result, Boundary Layer Technologies aims to provide a viable alternative to the traditional airfreight industry, enhancing the efficiency of ocean freight delivery. By leveraging its advanced hydrofoil design, the company seeks to facilitate faster shipment times for the logistics sector.

Octant Bio

Series B in 2022
Octant Bio is a company focused on developing synthetic technology to enhance health and treat diseases. The firm employs synthetic biology, genome engineering, next-generation sequencing, and computational tools to measure the activity of thousands of receptor pathways in human cells simultaneously. This approach allows scientists to use machine learning methods to engineer small molecules that can interact with multiple receptors, offering new potential for treating complex diseases.

Ansa Biotechnologies

Series A in 2022
Ansa Biotechnologies, Inc. is a biotechnology company based in Berkeley, California, focused on developing innovative DNA synthesis technology utilizing enzymes. Founded in 2018, the company aims to transform the traditional methods of DNA production, which have remained largely unchanged for decades. Ansa's enzymatic approach promises to be faster, more accurate, and environmentally friendly compared to conventional chemical methods. This advanced technology facilitates the synthesis of gene-length oligonucleotides, enabling medical researchers to create synthetic genes efficiently. Ansa Biotechnologies' offerings are designed to support a wide range of applications in biological research, diagnostics, therapeutics, and biomanufacturing, ultimately accelerating innovation in the field of biotechnology.

BillionToOne

Series C in 2022
BillionToOne Inc. is a precision diagnostics company focused on developing advanced genetic testing platforms that detect and quantify diseases at the molecular level. Established in 2016 and headquartered in Menlo Park, California, the company offers a noninvasive prenatal screening solution called UNITY, which analyzes fetal cell-free DNA from a single blood sample provided by the mother. This test can identify single-gene disorders such as cystic fibrosis, spinal muscular atrophy, and thalassemia, thereby providing a safer alternative to invasive procedures like amniocentesis. Beyond prenatal diagnostics, BillionToOne is also developing oncology assays that enable the detection of actionable mutations and monitor tumor burden through blood samples, allowing for more precise therapy selection and monitoring. The company's innovative technologies aim to make genetic testing both accurate and accessible, ensuring that a broader spectrum of patients can benefit from advanced medical diagnostics.

Antora Energy

Series A in 2022
Antora Energy specializes in providing zero-carbon industrial heat and power solutions for heavy industries, offering a more reliable alternative to fossil fuels. The company develops innovative thermal batteries that utilize excess solar and wind electricity to heat blocks of carbon, creating a sustainable energy source. These thermal energy storage systems effectively convert heat energy into electric energy, facilitating the electrification of heavy industry. By enabling the integration of renewable resources into the electricity grid, Antora Energy aims to deliver convenient, sustainable, and reliable electricity while significantly reducing carbon emissions on a global scale.

Zero Acre Farms

Series A in 2022
Zero Acre Farms is a food company dedicated to eliminating the food industry's reliance on harmful vegetable oils. It offers a sustainable alternative created through microorganisms and fermentation technology. This innovative approach results in oils and fats that contain significantly lower levels of unhealthy fats associated with inflammation and various diseases. By providing healthier options, Zero Acre Farms aims to support consumers in maintaining a nutritious diet while promoting sustainable food practices.

Athelas

Venture Round in 2022
Athelas, Inc., founded in 2002 and based in Mountain View, California, develops and manufactures portable blood analysis devices designed for at-home use. The company's technology focuses on monitoring chronically ill patients by providing diagnostic reports from a drop of blood, helping to identify conditions such as leukemia, infections, and inflammatory diseases early. Athelas has deployed an FDA-cleared blood diagnostic device along with other sensors to manage various health metrics including Blood Pressure, Weight, Glucose, and Medication Adherence. The company operates as a subsidiary of MerLion Pharmaceuticals Pte. Ltd.

MultiOmic Health

Seed Round in 2022
MultiOmic Health is a company focused on addressing metabolic syndrome-related diseases through AI-enabled drug discovery. It collaborates with healthcare providers to gather and analyze de-identified patient data and bio-samples. The company's MOHSAIC® platform integrates multi-omics analysis, computational systems biology modeling, and targeted laboratory experiments to develop novel precision therapeutic concepts. These concepts are then commercialized through partnerships with established biopharma companies.

64x Bio

Series A in 2022
64x Bio is a biotechnology company that specializes in accelerating the discovery of mammalian cell lines for biomanufacturing and therapeutic applications. The company has developed a high-throughput discovery and screening platform that integrates advanced computational design techniques. This platform enables the creation of highly optimized cell lines specifically tailored for the production of viral vectors, which are crucial for cell and gene therapies. By providing purpose-built genetically engineered cell lines, 64x Bio aims to enhance the efficiency of viral vector production, helping pharmaceutical and biotechnology companies improve their manufacturing capabilities while reducing associated costs.

HealthLeap

Pre Seed Round in 2022
HealthLeap is a company dedicated to enhancing global health through improved nutrition, specifically targeting disease-related malnutrition, a critical issue responsible for increased morbidity and mortality among hospital patients. The company has developed an AI-based clinical assistant that serves as a risk screening tool for healthcare professionals, allowing for optimized treatment plans and better clinical outcomes. By providing automated medical calculations and analysis-driven recommendations, HealthLeap equips clinicians to effectively prevent and address malnutrition, which remains underdiagnosed despite its prevalence in hospital settings. Through its innovative approach, HealthLeap aims to mitigate the impact of malnutrition on patient health and reduce associated healthcare costs.

Tangible

Pre Seed Round in 2022
Tangible is a climate technology company focused on building sustainable materials that are not harmful to the environment. Tangible is a unified software platform that catalyzes the adoption of sustainable building materials by allowing real estate developers, architects, and contractors to seamlessly identify, manage, and report on products that meet their carbon, environmental, and social goals. Founded in 2021 by Nicole Granath and Anneli Tostar, Tangible is headquartered in San Francisco, California, United States.

InVivo AI

Seed Round in 2021
InVivo AI is a Montreal-based company founded in 2017 that specializes in leveraging artificial intelligence to enhance pharmaceutical research and development, with a particular focus on preclinical toxicology. The company has developed advanced AI methods for molecular representation, structure and ligand-based de novo design, and multiparameter optimization, enabling the creation of novel chemistry to address complex biological challenges.

Nabla Bio

Seed Round in 2021
Nabla Bio is a biotechnology company that specializes in the development of an autoreverse platform for the discovery of innovative protein variants. These proteins, which exhibit unique qualities, are engineered to create new medicines and enhance nutritional products. By leveraging insights gained from billions of natural proteins, Nabla Bio enhances these variants through extensive experimentation, allowing for advanced applications in both medical and industrial fields. The company's focus on complex measurements of protein function positions it as a leader in the pursuit of previously unattainable protein capabilities.

Planet A Foods

Seed Round in 2021
Planet A Foods is a producer of plant-based, cocoa-free chocolate that focuses on creating food products from natural ingredients. The company emphasizes local production to minimize the impact on land and resources while aiming to reduce global carbon emissions. By utilizing traditional fermentation techniques, Planet A Foods offers an alternative to conventional chocolate, allowing consumers to enjoy chocolate flavors without the associated environmental drawbacks of unsustainable cocoa production.

Superdao

Pre Seed Round in 2021
Superdao is a platform designed for the management and operation of decentralized autonomous organizations (DAOs). It provides tools for creating and customizing intelligent contracts, managing contributors, and accessing a member directory and treasury dashboard. Additionally, Superdao offers a wallet analytics feature that delivers insights into dapp users, NFT and token holders, DAO voters, and quest participants, allowing organizations to analyze their audiences and gather competitive insights. The platform is tailored for Web3 growth teams, facilitating improved decision-making and governance structures for decentralized ventures. With preloaded data from numerous top Web3 projects, Superdao enhances the ability of businesses to build target lists and leverage third-party applications, ultimately supporting the collaborative management of innovative and economically viable decentralized applications.

WorldCoin

Venture Round in 2021
WorldCoin is a company that focuses on creating a privacy-centric digital currency platform designed to enhance global connectivity and trust among users. It offers a secure digital identity solution through its iris-scanning device, which generates a unique World ID, allowing individuals to manage their biometric information and digital assets securely. The platform operates on a permissionless blockchain, ensuring transparency and privacy in transactions. Additionally, the World App facilitates easy access to various Mini Apps while enabling users to store their World ID and digital assets effectively. By prioritizing user privacy, WorldCoin aims to discourage fraudulent activities and promote a trustworthy environment for digital interactions.

LatchBio

Seed Round in 2021
LatchBio is a biotechnology company founded in 2021 by Alfredo Andere, Kyle Giffin, and Kenny Workman. It focuses on developing a data infrastructure aimed at supporting the open-source biocomputing revolution. The company provides a bioinformatics platform specifically designed for cell and gene therapy startups, offering a modern cloud computing stack that enables biotech labs to manage and execute custom workflows, pipelines, and machine learning models. This platform allows scientists to create bioinformatic queries efficiently, without requiring command-line expertise or the burdens of complex system setups. By streamlining data integration and computational processes, LatchBio helps biotech companies accelerate therapeutic discovery and reduce engineering costs.

Journey Clinical

Seed Round in 2021
Journey Clinical is a platform that provides services to member psychotherapy practices that are independently owned and operated, and in no way owns, directs, or controls the mental healthcare clinicians providing care.

unspun

Series A in 2021
Unspun, Inc. is a digital apparel company based in San Francisco, California, founded in 2015. It specializes in creating custom jeans tailored to individual consumers using advanced body scanning technology, fit algorithms, and additive manufacturing. The company aims to address environmental challenges by minimizing pattern-cutting waste and unsold inventory, thus contributing to a reduction in global carbon emissions. Unspun's innovative approach enables on-demand production of jeans in under ten minutes, utilizing localized manufacturing processes designed to be zero-waste. Its technology has gained recognition, including being named one of TIME's Best Inventions of 2019, and supports a B2B platform that facilitates digital customization for major apparel brands.

Solugen

Series C in 2021
Solugen, Inc. is a specialty chemicals company based in Houston, Texas, founded in 2016. It focuses on producing industrial chemicals through the application of biotechnology and green chemistry, specifically utilizing plant-derived substitutes to replace petroleum-based products. The company offers a range of products, including BioPeroxide, a carbon-negative hydrogen peroxide, and BioChelate, a biodegradable chelant. Other offerings include ScavSol, a multivalent metal sequestrant for energy applications, ScaleSol, an alternative to phosphonates for scale control, and CorrSol, which addresses corrosion and fouling. Solugen's innovative approach combines fermentation and petrochemical processing along with advancements in synthetic biology and enzymatic technology, enabling it to create environmentally friendly chemicals from bio-based feedstocks. Its solutions cater to diverse industries such as agriculture, cleaning, energy, and water, contributing to reduced costs and lower carbon emissions while promoting sustainability.

Nabla Bio

Pre Seed Round in 2021
Nabla Bio is a biotechnology company that specializes in the development of an autoreverse platform for the discovery of innovative protein variants. These proteins, which exhibit unique qualities, are engineered to create new medicines and enhance nutritional products. By leveraging insights gained from billions of natural proteins, Nabla Bio enhances these variants through extensive experimentation, allowing for advanced applications in both medical and industrial fields. The company's focus on complex measurements of protein function positions it as a leader in the pursuit of previously unattainable protein capabilities.

Talus Bio

Pre Seed Round in 2021
Talus Bio is a biotechnology startup focused on drug discovery and development, particularly targeting challenging cancer transcription factors. The company employs an innovative approach that integrates functional proteomics, automated biology, and machine learning. Their MARMOT platform utilizes AI, advanced proteomics, synthetic chemistry, and computational biology to design and analyze drugs, proteins, and genomics. This platform is designed to advance drug development for gene regulation in oncology, aiming to create small-molecule therapies that can effectively control gene expression in cancer cells.

Earth AI

Seed Round in 2021
Earth AI, established in 2016 and based in Parramatta, Australia, specializes in AI-driven mineral exploration. It uses satellite, geophysical, and geochemical data to generate precise geological maps and suggest locations for mineral exposure, particularly for critical metals like copper, lead, zinc, nickel, cobalt, vanadium, and rare earth elements. This predictive approach helps mining explorers enhance their discovery prospects while reducing operational risks and costs.

Talus Bio

Seed Round in 2021
Talus Bio is a biotechnology startup focused on drug discovery and development, particularly targeting challenging cancer transcription factors. The company employs an innovative approach that integrates functional proteomics, automated biology, and machine learning. Their MARMOT platform utilizes AI, advanced proteomics, synthetic chemistry, and computational biology to design and analyze drugs, proteins, and genomics. This platform is designed to advance drug development for gene regulation in oncology, aiming to create small-molecule therapies that can effectively control gene expression in cancer cells.

Nobell Foods

Series B in 2021
Nobell Foods is a biotech company based in San Francisco, California, that specializes in developing and producing animal-based food substitutes using plant materials. Founded in 2016, the company aims to transform plants into bioreactors to generate protein, unlocking their potential to create innovative food alternatives. By focusing on plant-based solutions, Nobell Foods seeks to provide sustainable options that can replace traditional animal products, contributing to a more environmentally friendly food system.

Atom Computing

Series A in 2021
Atom Computing Inc. is a technology company based in Berkeley, California, focused on the development of scalable quantum computers utilizing individual atoms. Founded in 2018, the company leverages the quantum mechanical properties of these atoms to process information and tackle complex problems that are beyond the capabilities of traditional computing. Atom Computing's innovative approach enables precise control, scaling, and stabilization of atoms, allowing quantum engineers and researchers to conduct advanced calculations in various fields, including drug design, computational chemistry, and other areas of general computing.

Varda

Series A in 2021
Varda Space Industries, Inc. is a space manufacturing startup based in San Francisco, California, founded in 2020 by Delian Asparouhov and Trae Stephens. The company specializes in creating products in space that are intended for terrestrial applications, leveraging the unique advantages of low gravity. Varda aims to establish an infrastructure for harvesting materials from asteroids, enabling the production of new products in space. This approach not only facilitates the manufacturing of innovative goods but also promotes sustainability by reducing reliance on the destructive extraction of Earth's resources.

Meati

Series B in 2021
Meati Foods is a consumer goods company based in Boulder, Colorado, that specializes in the production and sale of fungi-based meat alternatives. Founded in 2016, the company aims to provide nutrient-dense, plant-based options that serve as sustainable substitutes for traditional meat. Meati's products are crafted using proprietary fermentation technologies and are minimally processed, ensuring they are free from common allergens. The company is committed to offering vegan food choices that are accessible and enjoyable for a diverse range of consumers.

Mindset Health

Seed Round in 2021
Mindset Health is a digital therapeutics company based in Melbourne, Victoria, founded by Alex Naoumidis in 2018. The company develops an app-based hypnotherapy platform designed to help individuals manage chronic health issues, particularly irritable bowel syndrome, anxiety, and chronic pain. The platform offers a safe and nonaddictive alternative for treatment, allowing users to improve their conditions without the need for dietary changes. In addition to addressing irritable bowel syndrome, Mindset Health's solutions aim to enhance sleep quality and reduce stress, anxiety, and pain associated with various chronic conditions. Through its innovative approach, Mindset Health provides accessible and cost-effective healthcare options for those seeking relief from chronic health challenges.

BillionToOne

Series B in 2021
BillionToOne Inc. is a precision diagnostics company focused on developing advanced genetic testing platforms that detect and quantify diseases at the molecular level. Established in 2016 and headquartered in Menlo Park, California, the company offers a noninvasive prenatal screening solution called UNITY, which analyzes fetal cell-free DNA from a single blood sample provided by the mother. This test can identify single-gene disorders such as cystic fibrosis, spinal muscular atrophy, and thalassemia, thereby providing a safer alternative to invasive procedures like amniocentesis. Beyond prenatal diagnostics, BillionToOne is also developing oncology assays that enable the detection of actionable mutations and monitor tumor burden through blood samples, allowing for more precise therapy selection and monitoring. The company's innovative technologies aim to make genetic testing both accurate and accessible, ensuring that a broader spectrum of patients can benefit from advanced medical diagnostics.

Yuri

Seed Round in 2021
Yuri is a company specializing in the design and manufacturing of hardware for the aviation and aerospace industry. It offers a comprehensive range of services aimed at supporting microgravity research and experiments. These services encompass mission definition, hardware selection and development, as well as launch and return logistics. In addition to its focus on space missions, Yuri is involved in various scientific research areas, including growing cell cultures in 3D, modeling human diseases, analyzing proteins and molecules, synthetic biology, studying plant biology, and nanofluidics. This diverse expertise positions Yuri as a key player in advancing research capabilities within the aerospace sector.

MultiOmic Health

Pre Seed Round in 2021
MultiOmic Health is a company focused on addressing metabolic syndrome-related diseases through AI-enabled drug discovery. It collaborates with healthcare providers to gather and analyze de-identified patient data and bio-samples. The company's MOHSAIC® platform integrates multi-omics analysis, computational systems biology modeling, and targeted laboratory experiments to develop novel precision therapeutic concepts. These concepts are then commercialized through partnerships with established biopharma companies.

Gridware

Seed Round in 2021
Gridware is focused on enhancing and safeguarding the electrical grid, a critical infrastructure that, when compromised, can lead to severe consequences such as wildfires, property damage, and loss of life. The company has developed an advanced monitoring system that employs high-precision sensor arrays, including microphones and other sensing technologies, to continuously analyze the electrical and mechanical behavior of grid assets. This system incorporates an artificial intelligence processing unit that detects anomalies in the environment around power poles, enabling utilities to proactively address potential faults. By facilitating timely repairs and rapid responses to climatic anomalies, Gridware's technology improves safety, reliability, and reduces outage durations for utility companies. Headquartered in the Bay Area of Northern California, Gridware is privately held and supported by notable climate-tech and Silicon Valley investors, positioning itself to meet the growing demand for power while contributing to the future resilience of the electrical grid.

Multiply Labs

Series A in 2021
Multiply Labs is a pioneer in the field of personalized pharmaceuticals, specializing in the manufacturing of tailor-made capsules that cater to the unique needs of individual patients. By integrating advanced robotics technology with pharmaceutical science, the company has developed a unique robotic manufacturing facility capable of producing these customized capsules efficiently and cost-effectively. Multiply Labs stands out as the first company to introduce 3D printed capsules to the market, positioning itself at the forefront of innovation in individualized drug delivery. This approach allows for the creation of capsules that align with the specific metabolic requirements of patients, ultimately enhancing the effectiveness of pharmaceutical treatments.

Substack

Series B in 2021
Substack Inc. is an online platform based in San Francisco, California, that enables independent writers to create and distribute both paid and free subscription newsletters. Founded in 2017, Substack provides a suite of user-friendly tools designed for newsletter publishing, facilitating the simultaneous publication of content to email lists and websites. The platform simplifies the process of managing subscriber payments, making it easier for writers to monetize their work directly from their audiences. Additionally, Substack offers features that help stories reach wider audiences beyond paywalls and provides customizable design templates to enhance the reading experience. Through its innovative approach, Substack empowers writers to generate income from their newsletters while connecting with their subscribers effectively.

Faction

Seed Round in 2021
Faction specializes in the development of driverless electric vehicles that combine the speed and performance of cars with the affordability of motorcycles. The company focuses on micro-delivery and ride-on-demand services, utilizing a model that integrates remote human supervision alongside autonomous technology. This approach allows Faction to bypass the limitations of fully autonomous systems, enabling quicker deployment of its services. The vehicles are designed with networked data capabilities, over-the-air software updates, and safety-critical autonomy features, ensuring a cost-effective and reliable driverless solution for clients. After completing its first prototypes, Faction is set to commence trials to further refine its offerings in the transportation sector.

Noya

Seed Round in 2021
Noya is a company focused on combating climate change through innovative carbon capture technology. By retrofitting existing industrial cooling towers, Noya integrates a non-toxic chemical blend that efficiently captures carbon dioxide without requiring physical alterations to the equipment. This approach allows industries to reduce their carbon footprints while simultaneously generating a valuable resource, as the captured CO2 is sold to companies that utilize it as a raw material. Noya's mission is to accelerate the global transition towards a carbon-negative future, positioning itself as a key player in the development of sustainable solutions for environmental challenges.

Brave Care

Series A in 2021
Brave Care, Inc. specializes in urgent pediatric health care services, providing treatment for a wide range of conditions such as allergies, asthma, cough, ear pain, eye problems, fever, minor fractures, and more. The company also offers pediatric-specific laboratory services and on-site x-ray facilities. Founded in 2019 and headquartered in Portland, Oregon, Brave Care operates primary and urgent care clinics designed exclusively for children in Oregon and Texas. In addition to in-person care, Brave Care provides pediatric advice to parents through its website and mobile app, supporting families nationwide in promoting their children's well-being.

WorkEQ

Pre Seed Round in 2020
WorkEQ is a business development and employment agency focused on fostering a flexible and productive work-life balance for organizations. The company has developed a contact tracing and health monitoring platform aimed at enhancing workplace safety by swiftly identifying potential exposure to infectious diseases among employees. This platform allows organizations to access critical data regarding symptom onset and infectious periods, enabling prompt responses to prevent viral outbreaks. By prioritizing health and safety, WorkEQ not only enhances employee engagement and productivity but also promotes a more inclusive work environment.

Oolu

Series B in 2020
Oolu Inc. is a solar energy company based in Dakar, Senegal, with an additional office in San Francisco, California. It specializes in the installation of solar home systems and provides technical support and maintenance services to households in West Africa. Oolu's offerings include solar systems equipped with adjustable lights and USB ports, powered by batteries that can hold a charge for up to six hours. The company aims to improve energy access for rural and peri-urban communities by implementing a monthly payment model that reduces financial barriers. This model not only allows customers to benefit from affordable and reliable energy but also includes maintenance, parts, and battery replacements within the service package. By fostering trust within local communities, Oolu seeks to expand its impact and become a leading provider of energy and financial services in the developing world.

Varda

Seed Round in 2020
Varda Space Industries, Inc. is a space manufacturing startup based in San Francisco, California, founded in 2020 by Delian Asparouhov and Trae Stephens. The company specializes in creating products in space that are intended for terrestrial applications, leveraging the unique advantages of low gravity. Varda aims to establish an infrastructure for harvesting materials from asteroids, enabling the production of new products in space. This approach not only facilitates the manufacturing of innovative goods but also promotes sustainability by reducing reliance on the destructive extraction of Earth's resources.

Kenota Health

Series A in 2020
Kenota Health is a company that specializes in the development of advanced diagnostic tools for allergy testing in humans. Their innovative point-of-care system streamlines the allergy testing process by utilizing a small blood sample, which is analyzed through their equipment to detect allergen sensitization within minutes. This non-invasive technology not only simplifies the testing procedure but also provides timely results directly to healthcare providers, enhancing the overall quality of diagnostic information available to physicians. By offering a safer and more cost-effective alternative to traditional allergy testing methods, Kenota Health aims to improve patient outcomes and facilitate better healthcare decision-making.

Deepcell

Series A in 2020
Deepcell, Inc. is a biotechnology company based in Mountain View, California, that specializes in single-cell analysis technology. Founded in 2015, the company has developed an AI-powered imaging and microfluidics platform that offers a non-invasive method for genetic testing with diagnostic-level accuracy. This platform enables researchers to classify and isolate viable cells based on their morphological characteristics, thus facilitating improved diagnosis and treatment of diseases. By providing detailed genetic health information through ordinary blood samples, Deepcell aims to enhance translational research, diagnostic testing, and therapeutic applications, ultimately reducing the need for invasive procedures in medical diagnostics.

64x Bio

Seed Round in 2020
64x Bio is a biotechnology company that specializes in accelerating the discovery of mammalian cell lines for biomanufacturing and therapeutic applications. The company has developed a high-throughput discovery and screening platform that integrates advanced computational design techniques. This platform enables the creation of highly optimized cell lines specifically tailored for the production of viral vectors, which are crucial for cell and gene therapies. By providing purpose-built genetically engineered cell lines, 64x Bio aims to enhance the efficiency of viral vector production, helping pharmaceutical and biotechnology companies improve their manufacturing capabilities while reducing associated costs.

Zero Acre Farms

Seed Round in 2020
Zero Acre Farms is a food company dedicated to eliminating the food industry's reliance on harmful vegetable oils. It offers a sustainable alternative created through microorganisms and fermentation technology. This innovative approach results in oils and fats that contain significantly lower levels of unhealthy fats associated with inflammation and various diseases. By providing healthier options, Zero Acre Farms aims to support consumers in maintaining a nutritious diet while promoting sustainable food practices.

Brightseed

Venture Round in 2020
Brightseed, Inc. is a pioneering biosciences company based in San Francisco, California, founded in 2017. It specializes in the discovery of bioactive compounds in plants that have beneficial effects on human health, particularly for chronic disease management. Utilizing its proprietary Forager platform, which incorporates artificial intelligence and machine learning, Brightseed accelerates the identification and validation of these naturally occurring compounds, transforming what was once a lengthy process into a matter of months. By mapping bioactives to specific health outcomes, Brightseed provides valuable insights and science-backed solutions to partners across the consumer health continuum. The company's innovative approach aims to illuminate the connections between nature and human health, ultimately improving quality of life and addressing health challenges through the exploration of previously uncharted plant compounds.

Manifold Bio

Seed Round in 2020
Manifold Biotechnologies, Inc. is a biotechnology company that specializes in developing platforms for the pharmacological measurement of various therapeutic protein variants. By integrating DNA technologies with machine learning, the company aims to create protein drugs that address challenging diseases. Manifold Bio's innovative approach includes a protein barcoding platform designed to enable multiplexed quantitation of protein therapeutics, thereby generating extensive data that enhances the drug development process. Founded in 2019 and located in Allston, Massachusetts, the company is focused on advancing measurement-driven design in the field of protein therapeutics.

Ukama

Seed Round in 2020
Ukama is a California-based company that specializes in creating LTE-based cellular network solutions for enterprises, internet service providers (ISPs), and individuals. The company provides a comprehensive range of hardware and software products that enable customers to build and manage their own cellular networks. By offering customizable network solutions, Ukama aims to help clients reduce costs, improve security, and enhance accessibility for on-campus users. Through its modern technology stack, Ukama facilitates the easy setup, deployment, and operation of LTE cellular networks, supporting various stakeholders in their connectivity needs.

Meati

Series A in 2020
Meati Foods is a consumer goods company based in Boulder, Colorado, that specializes in the production and sale of fungi-based meat alternatives. Founded in 2016, the company aims to provide nutrient-dense, plant-based options that serve as sustainable substitutes for traditional meat. Meati's products are crafted using proprietary fermentation technologies and are minimally processed, ensuring they are free from common allergens. The company is committed to offering vegan food choices that are accessible and enjoyable for a diverse range of consumers.

Rad AI

Seed Round in 2020
Rad AI, Inc. is a technology company based in Berkeley, California, specializing in artificial intelligence solutions for radiologists. Established in 2018, it has developed an automated report generation platform designed to streamline the radiology workflow. This platform enables radiologists to automate repetitive tasks, such as generating report impressions and dictating findings through voice recognition technology. Additionally, it assists in identifying errors and significant findings, automatically inserting customizable recommendation macros, and providing comprehensive answers to ordering clinicians. By integrating seamlessly into existing workflows, Rad AI enhances efficiency and accuracy, ultimately helping to alleviate burnout for radiologists and improve overall patient care.

Cover

Series A in 2020
Cover is a technology company that specializes in the design, manufacture, and installation of custom backyard studios and guesthouses. Its mission is to provide access to thoughtfully designed and well-built living spaces for a broader audience. By utilizing proprietary design software and a precision manufacturing system, Cover delivers high-quality, energy-efficient housing alternatives in significantly less time than traditional construction methods. The company focuses on enhancing living environments through an efficient process that includes design, permitting, manufacturing, and installation. Initially launched in Los Angeles, Cover is currently accepting pre-orders from customers around the world.

Geltor

Series B in 2020
Geltor, Inc. is a biodesign company focused on producing bioactive, animal-free collagens and proteins for a range of applications including beauty and nutrition. The company offers innovative products such as Collume, a bio-designed collagen technology that supports skincare cellular regeneration, and HumaColl21, which enhances the skin's appearance by boosting collagen, elastin, laminin, and fibronectin levels. Geltor also provides vegan collagen peptides and other novel proteins for use in functional foods and nutraceuticals. Established in 2015 and based in San Leandro, California, Geltor is committed to sustainable practices and aims to support a plant-based future through its clinically validated, biocompatible materials.

Ansa Biotechnologies

Seed Round in 2020
Ansa Biotechnologies, Inc. is a biotechnology company based in Berkeley, California, focused on developing innovative DNA synthesis technology utilizing enzymes. Founded in 2018, the company aims to transform the traditional methods of DNA production, which have remained largely unchanged for decades. Ansa's enzymatic approach promises to be faster, more accurate, and environmentally friendly compared to conventional chemical methods. This advanced technology facilitates the synthesis of gene-length oligonucleotides, enabling medical researchers to create synthetic genes efficiently. Ansa Biotechnologies' offerings are designed to support a wide range of applications in biological research, diagnostics, therapeutics, and biomanufacturing, ultimately accelerating innovation in the field of biotechnology.

Octant Bio

Series A in 2020
Octant Bio is a company focused on developing synthetic technology to enhance health and treat diseases. The firm employs synthetic biology, genome engineering, next-generation sequencing, and computational tools to measure the activity of thousands of receptor pathways in human cells simultaneously. This approach allows scientists to use machine learning methods to engineer small molecules that can interact with multiple receptors, offering new potential for treating complex diseases.

Manifold Bio

Pre Seed Round in 2020
Manifold Biotechnologies, Inc. is a biotechnology company that specializes in developing platforms for the pharmacological measurement of various therapeutic protein variants. By integrating DNA technologies with machine learning, the company aims to create protein drugs that address challenging diseases. Manifold Bio's innovative approach includes a protein barcoding platform designed to enable multiplexed quantitation of protein therapeutics, thereby generating extensive data that enhances the drug development process. Founded in 2019 and located in Allston, Massachusetts, the company is focused on advancing measurement-driven design in the field of protein therapeutics.

54gene

Series A in 2020
54gene is a biotechnology company founded in 2019 and headquartered in San Francisco, California, with additional offices in Lagos, Nigeria. The company focuses on unlocking the potential of the African genome to enhance genetic research and development, addressing a significant gap in the global genomics market where a majority of genetic data is derived from individuals of Caucasian descent. By developing a pan-African biobank, 54gene aims to identify new drug targets and create diagnostics and treatments for various diseases, including cancer, cardiovascular conditions, and neurodegenerative disorders. In addition to its research initiatives, the company offers genetic testing and molecular diagnostics services to patients and healthcare providers, ensuring compliance with international data privacy laws. Through its efforts, 54gene seeks to contribute to the discovery of medical advancements that can benefit diverse populations.

Rebellyous Foods

Series A in 2020
Rebellyous Foods is a Seattle-based company that specializes in producing plant-based meat products, including chicken nuggets, patties, and chicken strips. Founded in 2017, the company aims to achieve price parity with animal-based meat by implementing advanced food manufacturing equipment and processes. Rebellyous Foods serves various sectors such as schools, hospitals, corporate cafeterias, and restaurants. The company focuses on large-scale production using high-throughput automation and innovative low-energy tools to create affordable plant-based meat alternatives.

Solugen

Series B in 2020
Solugen, Inc. is a specialty chemicals company based in Houston, Texas, founded in 2016. It focuses on producing industrial chemicals through the application of biotechnology and green chemistry, specifically utilizing plant-derived substitutes to replace petroleum-based products. The company offers a range of products, including BioPeroxide, a carbon-negative hydrogen peroxide, and BioChelate, a biodegradable chelant. Other offerings include ScavSol, a multivalent metal sequestrant for energy applications, ScaleSol, an alternative to phosphonates for scale control, and CorrSol, which addresses corrosion and fouling. Solugen's innovative approach combines fermentation and petrochemical processing along with advancements in synthetic biology and enzymatic technology, enabling it to create environmentally friendly chemicals from bio-based feedstocks. Its solutions cater to diverse industries such as agriculture, cleaning, energy, and water, contributing to reduced costs and lower carbon emissions while promoting sustainability.

Catalog

Series A in 2020
Catalog Technologies Inc. specializes in a DNA-based platform that revolutionizes digital data storage and computation. Founded in 2016 and headquartered in Boston, Massachusetts, the company provides a method for encoding digital information into DNA, making it a viable and cost-effective solution for long-term data archiving. By leveraging advanced synthetic biology technologies, Catalog aims to transform how information is stored, allowing customers to utilize DNA molecules as a primary medium for digital records. This innovative approach positions Catalog at the forefront of next-generation data storage solutions.

Microverse

Seed Round in 2020
Microverse is an online school dedicated to training remote software developers through a collaborative learning platform. Its mission is to educate and connect one million individuals with remote job opportunities by 2030. The school offers full-stack web development programs that utilize income share agreements, allowing students to pay for their education based on future earnings. Students engage in small, distributed teams, participating in remote pair programming and working on open source and freelance projects. This approach fosters accountability and collective learning while equipping students with the necessary coding skills and career guidance. By enabling individuals to become professional remote developers, Microverse facilitates global employment opportunities for both students and companies seeking to hire talent without geographic limitations.

BillionToOne

Series A in 2020
BillionToOne Inc. is a precision diagnostics company focused on developing advanced genetic testing platforms that detect and quantify diseases at the molecular level. Established in 2016 and headquartered in Menlo Park, California, the company offers a noninvasive prenatal screening solution called UNITY, which analyzes fetal cell-free DNA from a single blood sample provided by the mother. This test can identify single-gene disorders such as cystic fibrosis, spinal muscular atrophy, and thalassemia, thereby providing a safer alternative to invasive procedures like amniocentesis. Beyond prenatal diagnostics, BillionToOne is also developing oncology assays that enable the detection of actionable mutations and monitor tumor burden through blood samples, allowing for more precise therapy selection and monitoring. The company's innovative technologies aim to make genetic testing both accurate and accessible, ensuring that a broader spectrum of patients can benefit from advanced medical diagnostics.

Astranis

Series B in 2020
Astranis is a company focused on developing innovative satellite technology designed to deliver data to specific locations on Earth with each satellite it launches. The primary mission of Astranis is to provide high-speed, reliable internet access to underserved regions at a significantly lower cost compared to traditional methods. By doing so, the company aims to bridge the digital divide and connect the approximately 4 billion people worldwide who currently lack internet access, thereby supporting governments and businesses in their efforts to expand global connectivity.

Advano

Series A in 2020
Advano, also known as NanoStar, Inc., is a New Orleans-based company that specializes in silicon nanotechnology, focusing on the development of advanced silicon anode materials for lithium-ion batteries. Founded in 2014 and a graduate of Y Combinator in 2017, Advano offers scalable solutions that enhance the energy density and longevity of lithium-ion batteries by integrating or replacing traditional graphite components. Its innovative products cater to various industries, including electric vehicles and consumer electronics, and are designed to improve energy storage and charging capabilities. By providing low-cost, high-performance materials, Advano aims to support the domestic battery supply chain and facilitate the transition to sustainable energy solutions.

UPSIDE Foods

Series B in 2020
UPSIDE Foods, formerly known as Memphis Meats, is a cultivated meat company founded in 2015 and headquartered in Berkeley, California. The company specializes in producing real meat, poultry, and seafood directly from animal cells, eliminating the need to raise and slaughter animals. This innovative approach significantly reduces the resource consumption associated with traditional meat production, requiring less water, land, and energy. UPSIDE Foods aims to offer consumers clean, humane, and sustainable meat products, such as beef meatballs, chicken, and duck, all grown in controlled environments. The company is led by Dr. Uma Valeti, who is committed to transforming the food industry with healthier and environmentally friendly alternatives to conventional meat.

Arpeggio Bio

Seed Round in 2020
Arpeggio Bio, established in 2017 and headquartered in Boulder, Colorado, specializes in developing innovative software that captures snapshots of cellular RNA activity. By combining biological assays with advanced machine learning algorithms, the company enables pharmaceutical and biotechnology firms to understand a drug's mechanism of action at low sequencing depths. Arpeggio Bio's technology reveals intricate biological networks, facilitating more informed therapeutic development.

Farcast

Pre Seed Round in 2019
We build advanced satcom terminals

Antora Energy

Seed Round in 2019
Antora Energy specializes in providing zero-carbon industrial heat and power solutions for heavy industries, offering a more reliable alternative to fossil fuels. The company develops innovative thermal batteries that utilize excess solar and wind electricity to heat blocks of carbon, creating a sustainable energy source. These thermal energy storage systems effectively convert heat energy into electric energy, facilitating the electrification of heavy industry. By enabling the integration of renewable resources into the electricity grid, Antora Energy aims to deliver convenient, sustainable, and reliable electricity while significantly reducing carbon emissions on a global scale.

Lively

Series B in 2019
Lively, Inc. is a health savings account (HSA) platform designed for both employers and individuals. Established in 2016 and headquartered in San Francisco, California, Lively offers a user-centric solution that enhances the experience of managing HSAs. Its platform enables consumers to optimize their healthcare spending and maximize savings, ultimately improving their overall financial well-being. By providing an intuitive interface, Lively aims to simplify healthcare management for users, making it easier for them to navigate HSA-compatible plans.

Brave Care

Seed Round in 2019
Brave Care, Inc. specializes in urgent pediatric health care services, providing treatment for a wide range of conditions such as allergies, asthma, cough, ear pain, eye problems, fever, minor fractures, and more. The company also offers pediatric-specific laboratory services and on-site x-ray facilities. Founded in 2019 and headquartered in Portland, Oregon, Brave Care operates primary and urgent care clinics designed exclusively for children in Oregon and Texas. In addition to in-person care, Brave Care provides pediatric advice to parents through its website and mobile app, supporting families nationwide in promoting their children's well-being.

Earth AI

Seed Round in 2019
Earth AI, established in 2016 and based in Parramatta, Australia, specializes in AI-driven mineral exploration. It uses satellite, geophysical, and geochemical data to generate precise geological maps and suggest locations for mineral exposure, particularly for critical metals like copper, lead, zinc, nickel, cobalt, vanadium, and rare earth elements. This predictive approach helps mining explorers enhance their discovery prospects while reducing operational risks and costs.
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