First Star Ventures

First Star Ventures, established in 2014 and based in Cambridge, Massachusetts, is a venture capital firm that focuses on early-stage investments in technology and biotechnology sectors across the United States. The firm seeks to partner with visionary founders who are addressing real-world challenges through applications of advanced technologies, including artificial intelligence, computational biotech, connected sensors, augmented reality, virtual reality, and blockchain. By leveraging its industry experience and a network of strategic partners, First Star Ventures aims to support startups in their growth and innovation, fostering the development of solutions that harness frontier technologies for a better future.

Teddy Blank

Principal

41 past transactions

FYTO

Series A in 2022
FYTO provides innovative solutions which improve the economic and environmental sustainability of agriculture for farmers around the world. FYTO is developing: NOVEL NUTRIENT-DENSE CROPS that have ultra-high yields and ultra-low resource requirements, STATE-OF-THE ART CULTIVATION AND HARVESTING SYSTEMS for exceptional quality and consistency, CLIMATE-FRIENDLY METHODOLOGIES for resiliency and long-term sustainability, and a range of GROUNDBREAKING AGRICULTURAL PRODUCTS such as animal feed and biofertilizer.

VistaPath

Seed Round in 2022
VistaPath Biosystems, Inc. specializes in developing an automated tissue grossing platform aimed at modernizing pathology laboratories. Founded in 2017 and based in Cambridge, Massachusetts, the company offers the VistaPath Sentinel, which automates the inspection, description, inking, and measurement of tissue samples intended for diagnosis. This platform enhances efficiency by automatically locating, measuring, and imaging tissue as it is placed into cassettes, thereby minimizing mix-ups and errors. Additionally, it generates comprehensive gross reports that include patient and clinician information, as well as images of the relevant containers and labels. By leveraging advanced technology, VistaPath enables pathologists to streamline sample preparation and improve diagnostic accuracy.

Salient

Seed Round in 2022
Developer of weather prediction software designed to use ocean data and machine learning to predict precipitation and temperature. The company's software provides accurate long-range weather forecasts and predicts heat and cold waves, floods as well and droughts, enabling businesses to forecast weather for diverse applications across agriculture, energy and utilities, insurance, finance, and commodities.

Enzymit

Seed Round in 2022
Enzymit is a developer of a discovery platform focused on creating new-to-nature enzymes through advanced computational design and deep learning. The company employs high-throughput testing methods to innovate novel enzymes applicable across various sectors, including fine chemical manufacturing, food technology, health, and biodefense. By leveraging these technologies, Enzymit aims to help global manufacturers enhance production efficiency, reduce operational costs, and support sustainability initiatives in their processes.

Robigo

Pre Seed Round in 2021
Robigo specializes in biopesticide development by engineering the plant microbiome to enhance crop health and mitigate diseases. The company focuses on creating precision microbial treatments that not only improve plant vitality but also help recover lost agricultural yields. Utilizing advanced microbial engineering and data science, Robigo's products are designed to be effective while ensuring safety for beneficial microbes, pollinators, humans, and the broader environment. This approach enables farmers to boost their productivity and profitability while promoting sustainable farming practices.

Kanary

Pre Seed Round in 2021
Developer of an online privacy platform designed to remove private information once it is discovered. The company's platform actively monitors websites for personal information and removes it from any website that is at risk, enabling individuals to protect their digital identity.

Oort

Seed Round in 2020
Oort is a developer of a network security platform that aims to enhance vendor access and risk management for enterprise businesses. The platform offers security teams comprehensive visibility and control over their identity attack surface, addressing complex challenges at the intersection of cloud, networking, security, and distributed computing. By leveraging a federation of globally distributed data centers, Oort delivers robust network solutions that effectively detect and respond to identity threats, thereby securing the digital supply chain. The company's team comprises experienced professionals from leading firms in the networking and security sectors, and it has garnered support from notable investors in the venture capital space.

Sia

Seed Round in 2020
Sia is the leading decentralized cloud storage platform. No signups, no servers, no trusted third parties. Sia leverages blockchain technology to create a data storage marketplace that is more robust and more affordable than traditional cloud storage providers.

Nebulous

Seed Round in 2020
Nebulous, Inc. is a company focused on developing blockchain hardware and software for the decentralized internet. Founded in 2014 and based in Boston, Massachusetts, it operates Sia, a decentralized cloud storage platform that creates a marketplace for data storage by connecting users in need of file storage with hosts offering underutilized hard drive capacity. Utilizing blockchain technology, Sia enhances security and cost-effectiveness, enabling transactions through smart contracts without the need for intermediaries. In addition to Sia, Nebulous offers Skynet, a decentralized content delivery network and file-sharing platform designed for developers, and SiaStream, which provides affordable storage solutions for media files, facilitating quick streaming. Through these initiatives, Nebulous aims to deliver a robust and economical alternative to traditional cloud storage providers.

Phaseshift Technologies

Pre Seed Round in 2020
At Phaseshift, we develop novel high performance alloys using Computational Chemistry and Machine Learning. Our Machine Learning models are trained to predict material properties associated with a large range of alloy compositions in a a few seconds. This, along with our computational chemistry models, enable us to model the behavior of any alloy composition in a time and cost efficient way without any compromises with the accuracy. We use our solution to develop materials for our clients that have a very specific set of needs that are unmet by existing material choices. Currently we are focused on a specialized class of materials - Amorphous Alloys and High Entropy Alloys. These materials are often considered as some of the toughest materials known to us but are less easily commercialized than traditional alloys. Some use cases of these alloys are found in the bio-medical industry, aerospace industry, nuclear industry, etc. We can also optimize our materials for the ever evolving manufacturing landscape and are currently working on projects that involve optimizing are materials for Additive Manufacturing.

FYTO

Pre Seed Round in 2020
FYTO provides innovative solutions which improve the economic and environmental sustainability of agriculture for farmers around the world. FYTO is developing: NOVEL NUTRIENT-DENSE CROPS that have ultra-high yields and ultra-low resource requirements, STATE-OF-THE ART CULTIVATION AND HARVESTING SYSTEMS for exceptional quality and consistency, CLIMATE-FRIENDLY METHODOLOGIES for resiliency and long-term sustainability, and a range of GROUNDBREAKING AGRICULTURAL PRODUCTS such as animal feed and biofertilizer.

EnPowered

Seed Round in 2020
EnPowered is a company focused on helping businesses manage their energy consumption and costs effectively. It offers free audits of energy bills that can lead to cost reductions of up to 70%. The company utilizes analytics to further optimize energy usage, providing energy retrofits that help lower consumption. EnPowered also enables small businesses to collaborate in group-buying initiatives, allowing them to secure lower electricity rates. Additionally, the company has developed a platform that tracks energy usage, facilitates on-bill payment, and predicts spikes in electricity prices, encouraging users to adjust their consumption accordingly. This empowers both energy providers and homeowners to monitor and control their energy usage, ultimately leading to reduced electricity bills and enhanced savings.

EnPowered

Debt Financing in 2020
EnPowered is a company focused on helping businesses manage their energy consumption and costs effectively. It offers free audits of energy bills that can lead to cost reductions of up to 70%. The company utilizes analytics to further optimize energy usage, providing energy retrofits that help lower consumption. EnPowered also enables small businesses to collaborate in group-buying initiatives, allowing them to secure lower electricity rates. Additionally, the company has developed a platform that tracks energy usage, facilitates on-bill payment, and predicts spikes in electricity prices, encouraging users to adjust their consumption accordingly. This empowers both energy providers and homeowners to monitor and control their energy usage, ultimately leading to reduced electricity bills and enhanced savings.

Salient

Pre Seed Round in 2020
Developer of weather prediction software designed to use ocean data and machine learning to predict precipitation and temperature. The company's software provides accurate long-range weather forecasts and predicts heat and cold waves, floods as well and droughts, enabling businesses to forecast weather for diverse applications across agriculture, energy and utilities, insurance, finance, and commodities.

Winterlight Labs

Series A in 2019
Winterlight Labs Inc. develops a speech-based platform for detecting cognitive and mental diseases such as, dementia and Alzheimer’s disease. Its AI (artificial intelligence) diagnostic platform assesses and monitors cognitive health by quantifying speech and language patterns. The company's platform has applications in clinical trials, long-term and primary care, and speech-language pathology. Winterlight Labs Inc. was founded in 2015 and is based in Toronto, Canada.

Gradient

Venture Round in 2019
Gradient is a developer of secure software that addresses fundamental issues of trust and authenticity in the digital landscape. The company's solutions focus on redefining identity and data authentication, providing a framework for establishing trust and facilitating the sharing of provable statements while ensuring privacy and security. This enables users to collaborate openly without sacrificing digital security or integrity. Gradient's infrastructure is designed to foster decentralized trust, contributing to safer and more reliable digital interactions.

Swiftly

Seed Round in 2019
Swiftly, Inc. is a technology company that develops a platform designed to enhance the shopping experience for supermarkets and retailers. Founded in 2014 and based in Shelton, Washington, Swiftly's applications enable retailers to offer personalized deals, loyalty programs, and streamlined checkout processes, which help bridge the gap between traditional brick-and-mortar shopping and e-commerce. By leveraging advanced technology and machine learning, Swiftly empowers grocery stores to improve customer engagement, enhance convenience, and remain competitive against online retailers. The platform not only enhances customer satisfaction but also creates new revenue opportunities for retailers.

Nomic

Pre Seed Round in 2019
Nplex Biosciences is a biotechnology company based in the United States that specializes in proteomic technology. The company has developed a platform that utilizes DNA nanotechnology to understand, detect, and treat diseases. Nplex offers a range of instruments and automation tools for measuring multiple proteins from blood samples, providing cost-effective solutions for protein data analysis. Its technology integrates seamlessly with industry-standard cytometers, enabling high-throughput analysis and the development of custom protein panels. Nplex aims to enhance existing instruments and workflows while facilitating automation in proteomic research and applications.

Scoot Science

Seed Round in 2019
Developer of ocean data analysis software designed to reduce marine risk through ocean observing and forecasting. The company's software uses autonomous underwater vehicles to access local ocean conditions and provide forecasts to fill the data gaps using a combination of traditional numerical ocean models and predictive artificial intelligence, enabling marine stakeholders with informed logistics and operation decisions to protect their marine assets.

Jellyfish

Seed Round in 2019
Jellyfish, Inc. specializes in developing an engineering management platform that enhances visibility and alignment between engineering teams and business objectives. The platform integrates with various tools to track tasks, analyze performance, and visualize resource allocation, thereby enabling leaders to make informed decisions based on data from product planning, issue tracking, and human resource systems. By providing insights into engineering operations, Jellyfish helps organizations improve productivity, strategic alignment, and overall efficiency in software delivery. Founded in 2007, the company is based in Boston, Massachusetts, with an additional office in Washington, D.C.

MotionHall

Seed Round in 2019
MotionHall Inc. is a technology solutions provider based in San Francisco, California, focusing on the biopharma sector. The company serves emerging biopharma firms, investment bankers, pharmaceutical companies, and venture capital markets. MotionHall has developed a market intelligence platform that utilizes machine learning and predictive matching algorithms to analyze the global landscape of partnerships and mergers and acquisitions in the pharmaceutical industry. This platform offers clients data-driven insights to enhance deal planning, improve financial outcomes, and increase confidence in product success. By providing predictive advisory on deal partners and transaction viability, MotionHall aims to streamline the deal-making process for its clients.

Plus One Robotics

Series A in 2018
Plus One Robotics Inc. specializes in developing advanced 3D vision and control systems for robotic automation in the logistics and e-commerce sectors. Founded in 2016 and headquartered in San Antonio, Texas, the company offers the PickOne Perception System, which accurately identifies the six degrees of freedom (DoF) pick pose of parcels. This information is transmitted to robots to facilitate the picking and placement of parcels onto induction conveyors. The system not only verifies the correct placement of parcels but also addresses errors by issuing commands to reposition misaligned packages. Plus One Robotics aims to alleviate labor shortages by automating repetitive tasks, allowing human workers to focus on more strategic activities. Their innovative approach to human-robot collaboration ensures that their systems are scalable, flexible, and resilient, ultimately enhancing customer service through improved sortation accuracy and streamlined operations.

Tranquil Data

Pre Seed Round in 2018
Tranquil Data is a Massachusetts-based computer software company founded in 2018 that focuses on digital transformation, cloud solutions, and business governance. The company offers a data accelerating platform that helps organizations capture and connect relevant data across various applications and databases. By automating the process of linking data to its context, Tranquil Data simplifies compliance for businesses and empowers them to analyze, innovate, and transform their operations. This platform enables compliance officers to manage rules effectively while allowing business roles to map data to its intended uses, ultimately helping organizations discover and validate new applications for their existing data.

Gradient

Seed Round in 2018
Gradient is a developer of secure software that addresses fundamental issues of trust and authenticity in the digital landscape. The company's solutions focus on redefining identity and data authentication, providing a framework for establishing trust and facilitating the sharing of provable statements while ensuring privacy and security. This enables users to collaborate openly without sacrificing digital security or integrity. Gradient's infrastructure is designed to foster decentralized trust, contributing to safer and more reliable digital interactions.

Plus One Robotics

Seed Round in 2018
Plus One Robotics Inc. specializes in developing advanced 3D vision and control systems for robotic automation in the logistics and e-commerce sectors. Founded in 2016 and headquartered in San Antonio, Texas, the company offers the PickOne Perception System, which accurately identifies the six degrees of freedom (DoF) pick pose of parcels. This information is transmitted to robots to facilitate the picking and placement of parcels onto induction conveyors. The system not only verifies the correct placement of parcels but also addresses errors by issuing commands to reposition misaligned packages. Plus One Robotics aims to alleviate labor shortages by automating repetitive tasks, allowing human workers to focus on more strategic activities. Their innovative approach to human-robot collaboration ensures that their systems are scalable, flexible, and resilient, ultimately enhancing customer service through improved sortation accuracy and streamlined operations.

Everbloom

Seed Round in 2018
Everbloom develops a platform for decentralized cryptocurrency exchange. The exchange offers services including non-custodial which utilize the blockchain for settlement and Ethereum & ERC20 Token which support for trading ether and ERC20 tokens. Everbloom was founded in 2017 and is headquartered in Boston, Massachusetts.

Feature Labs

Seed Round in 2018
Feature Labs, Inc. builds tools and application programming interfaces to deploy machine learning solutions by combining open source software and proprietary algorithms for automated feature engineering. The company's tools allow data science teams to utilize machine learning and artificial intelligence with structured data to deploy new products or services, identify critical insights, and understand what their data says about the future of their business. The company was founded in 2015 and is headquartered in Boston, Massachusetts. As of October 3, 2019, Feature Labs, Inc. operates as a subsidiary of Alteryx, Inc.

Plex Research

Seed Round in 2018
Plex Research, Inc. is a Cambridge, Massachusetts-based company that specializes in developing an AI-driven search engine for drug discovery. Founded in 2017, the platform is designed to analyze biomedical research data by employing advanced search algorithms. It focuses on mechanisms of action, toxicity, and optimization of compounds, while also generating screening sets tailored to specific targets, pathways, therapeutic indications, and phenotypes. By consolidating a vast array of biomedical information into a single search interface, Plex Research aims to streamline the process of finding critical literature and data for drug discovery, facilitating research and development in the pharmaceutical sector.

Reniac

Venture Round in 2017
rENIAC, Inc. designs and develops an intelligent data-aware architecture for applications, servers, and data stores. It develops a data engine platform that accelerates and optimizes open source database implementations for data-centric application. The company also provides Cassandra I/O accelerator; distributed and persistent cache; and storage engine for graphs and SQL databases. rENIAC, Inc. was incorporated in 2012 and is based in Santa Clara, California with additional locations in Hyderabad, India; and Richmond, Canada.

Genialis

Seed Round in 2017
Genialis, Inc. is a precision medicine data science company that specializes in biological data management and analysis. Founded in 2011 and based in Houston, Texas, Genialis has developed a web-based software platform that integrates computational biology and AI methods. This platform provides a comprehensive suite of visual analytics and bioinformatics tools that facilitate the storage, analysis, and interpretation of complex biological data. It enables both computational experts and non-experts to conduct advanced analyses while ensuring data transparency and reproducibility. Genialis collaborates with biopharma and big pharma companies to validate drug targets, predict biomarkers, and enhance drug discovery processes, ultimately aiming to improve patient outcomes through better treatment decisions and more effective therapeutics.

Resilinc

Venture Round in 2016
Resilinc Corporation specializes in cloud-based solutions for supply chain resiliency and risk management. The company offers a range of services that include supply chain mapping, crisis management, and a comprehensive resiliency management platform designed to facilitate collaborative mitigation efforts. Its EventWatch Professional service monitors global events that could disrupt supply chains, while the Resilinc CyberSCRM platform focuses on cybersecurity risk management for both direct and indirect suppliers. By utilizing a vast repository of supplier and part intelligence, Resilinc enables organizations to proactively plan for and respond to multi-tier disruptions. Founded in 2010 and headquartered in Palo Alto, California, Resilinc serves notable industry leaders, helping them enhance their competitive advantage and protect their supply chain integrity.

Nebulous

Seed Round in 2016
Nebulous, Inc. is a company focused on developing blockchain hardware and software for the decentralized internet. Founded in 2014 and based in Boston, Massachusetts, it operates Sia, a decentralized cloud storage platform that creates a marketplace for data storage by connecting users in need of file storage with hosts offering underutilized hard drive capacity. Utilizing blockchain technology, Sia enhances security and cost-effectiveness, enabling transactions through smart contracts without the need for intermediaries. In addition to Sia, Nebulous offers Skynet, a decentralized content delivery network and file-sharing platform designed for developers, and SiaStream, which provides affordable storage solutions for media files, facilitating quick streaming. Through these initiatives, Nebulous aims to deliver a robust and economical alternative to traditional cloud storage providers.

Upskill

Venture Round in 2015
Upskill provides wearable technology to connect hands-on workers from the factory to the warehouse to the jobsite. Its robust platform, Skylight, connects the industrial workforce with the people, processes, information, and equipment they need to do their jobs with greater efficiency and fewer errors, leaving them hands free to focus on their tasks at hand, and their tools. For organizations in the competitive global market looking to increase productivity, improve quality, reduce costs, train new workers, retain tribal knowledge, and provide a strong foundation for further investments, the future starts with Upskill.

Oculii

Seed Round in 2015
Oculii is an advanced radar sensor developer specializing in 4D radar design and fusion. 4D sensors have traditionally been the domain of high power, expensive military grade radar or laser systems. Backed by top-tier Silicon Valley angel investors and VCs - they've turned this paradigm on its head, leveraging advanced sensor fusion techniques to manufacture smarter, high precision sensors and systems. Their technology allows us to extract unprecedented accuracy, range, and 4D positioning information from commodity off the shelf low-cost radar elements, bringing high resolution radar imaging to the next frontier.

Seven Bridges

Seed Round in 2014
Seven Bridges is a leading infrastructure and data analytics company focused on advancing precision medicine through the analysis of biomedical data. The company provides a platform and services that support discovery and drug development for various entities, including academic institutions, biotechnology firms, government agencies, hospitals, and pharmaceutical companies. By collaborating with major genomics projects, Seven Bridges facilitates efficient, large-scale analysis of biomedical information. Recognized for its innovation, the company has received accolades from MIT Technology Review and has won multiple awards at the Bio-IT World conference. With offices located in Belgrade, Boston, Istanbul, and San Francisco, Seven Bridges continues to drive progress in the field of biomedical research.

Weft

Seed Round in 2014
Weft, Inc. is a global logistics data company based in Cambridge, Massachusetts, that specializes in providing real-time asset intelligence to enhance supply chain operations. Established in 2013 and operating as a subsidiary of Genscape, Inc., Weft integrates various tracking technologies, including Wi-Fi, BLE, GPS, satellite, and GPRS, to offer insights into logistics processes. The company's platform allows users to monitor and manage their assets, setting alerts for conditions such as location, temperature, and vibrations. By leveraging predictive analytics, Weft helps shippers anticipate potential bottlenecks by analyzing current locations and planned routes against historical data, enabling proactive adjustments to improve delivery timelines. The platform is accessible through web and mobile applications, and it collaborates with ERP providers, telecommunications companies, and logistics firms to extend its reach and capabilities within the industry.

Contastic

Seed Round in 2014
Contastic Inc. is a company based in Menlo Park, California, that specializes in a customer relationship management (CRM) system designed to enhance lead nurturing for sales professionals, realtors, freelancers, and consultants. The platform automatically generates personalized emails for users, utilizing data from Gmail and LinkedIn to identify when they last communicated with contacts and to tailor content based on the interests of prospects. This system operates over a secure encrypted channel, ensuring the privacy of user data while providing a daily digest of relevant news to keep users informed. Founded in 1996, Contastic Inc. has been functioning as a subsidiary of SugarCRM Inc. since March 2016.

Parallel Wireless

Seed Round in 2014
Parallel Wireless, Inc. is a company based in Nashua, New Hampshire, that specializes in developing innovative wireless cellular networks. Established in 2012, Parallel Wireless focuses on reimagining the architecture of the cellular radio access network (RAN) to effectively address the challenges posed by heterogeneous networks and facilitate the transition to 5G technology. The company offers a range of solutions, including a HetNet gateway that is 3GPP-compliant and utilizes software-defined networking (SDN) and network functions virtualization (NFV) to help operators scale and manage multi-vendor and multi-technology networks, including 3G, 4G, and Wi-Fi. Additionally, Parallel Wireless provides a converged wireless system that functions as a multi-radio access technology (multi-RAT) node, designed for versatile outdoor and in-vehicle deployment, ensuring comprehensive coverage.

Speedy Packets

Venture Round in 2014
Speedy Packets, Inc., founded in 2013 and based in Cambridge, Massachusetts, specializes in developing cloud-based software solutions that enhance TCP performance across various network types, including wireless, cellular, and satellite. The company offers a unique, patent-pending technology designed to improve Internet speed and quality for a wide range of connections, such as fiber, cable, DSL, and satellite. This technology enables users to stream videos, upload photos, and share content without interruptions or delays, ensuring a seamless online experience. By improving connectivity, Speedy Packets aims to keep users engaged and connected in an increasingly digital world.

Infinite Analytics

Seed Round in 2014
Infinite Analytics, Inc. specializes in providing a personalization platform tailored for ecommerce organizations globally. Founded in 2012 by two MIT graduates in Cambridge, Massachusetts, with an additional office in Mumbai, the company offers a suite of tools designed to enhance the online shopping experience. Its flagship products include Infinite Enrich, which transforms raw product data into actionable insights; Infinite Search, which delivers personalized search results to facilitate product discovery; and Infinite Recommend, which optimizes the purchasing journey through tailored recommendations drawn from a diverse array of over 20 widgets. The platform leverages advanced machine learning, natural language processing, and predictive analytics to develop a comprehensive understanding of customer behavior, thereby enabling businesses to increase conversions and reduce customer acquisition costs. Additionally, Infinite Analytics provides plugins and software development kits to support integration with various ecommerce platforms.
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