Hadean Ventures

Gesynta Pharma AB is a clinical-stage pharmaceutical company based in Stockholm, Sweden, founded in 2017. The company focuses on developing compounds that inhibit the pro-inflammatory enzyme microsomal prostaglandin E synthase-1 (mPGES-1) to address chronic inflammatory conditions, particularly in cardiovascular diseases and cancer. Its most advanced drug candidate, vipoglanstat (GS-248), is being developed as a non-hormonal treatment for endometriosis, a painful condition affecting around 10 percent of women of reproductive age. Clinical studies have indicated that vipoglanstat significantly reduces endometriotic lesions and provides pain relief, with preparations underway for a phase II clinical trial. Additionally, Gesynta Pharma is advancing another candidate, GS-073, which is set to enter phase I clinical trials for a different inflammatory condition. The company's research is rooted in work from the Karolinska Institutet, and it aims to deliver safe and effective treatments for serious diseases.

SciRhom GmbH is a biotechnology company focused on the preclinical and early clinical development of innovative biopharmaceuticals aimed at treating life-threatening autoimmune diseases. Established in 2016 through a collaboration between experienced academic and industry scientists, the company leverages extensive research and a robust network of experts in antibody development. SciRhom specializes in creating therapeutic antibodies targeting iRhom2, a significant modulator of several major pro-inflammatory signaling pathways, including TNF-alpha signaling. This focus allows the company to develop improved treatment options that enhance the protection of skin and intestinal barriers, ultimately benefiting patients suffering from serious autoimmune conditions.

Arthex Biotech S.L. is a biotechnology company founded in 2019 and based in Paterna, Spain. It specializes in the development of antisense RNA treatments specifically aimed at addressing genetic diseases and disorders where microRNAs play a significant role. As a spin-off from the University of Valencia, Arthex Biotech leverages a strong foundation in drug discovery and has a team comprising experts with extensive experience in neuromuscular diseases. The company focuses on creating innovative therapies for conditions with unmet medical needs, providing new treatment options for patients suffering from rare genetic diseases and other high-need medical issues. With guidance from esteemed scientific and clinical advisors, Arthex Biotech is committed to advancing its product development to improve patient outcomes.

Complement Therapeutics is a preclinical stage biotechnology company focused on addressing chronic diseases linked to the dysregulation of the complement system. The company has developed a precision medicine diagnostic platform that stratifies patients according to their complement-activation profiles. This innovative approach not only facilitates patient selection for future clinical trials but also serves as an efficacy biomarker, potentially enhancing medical treatment outcomes. By leveraging its platform methodology, Complement Therapeutics aims to improve the precision of treatments for patients suffering from conditions influenced by complement system dysregulation.

Alex Health AB, based in Stockholm, is an innovative startup focused on leveraging artificial intelligence and psychology to enhance mental health through behavioral change. Founded in 2017, the company is currently developing a second-generation behavioral change application aimed at helping one billion people overcome detrimental habits. Alex specializes in creating evidence-based digital therapeutics and software medical devices, which are CE-marked and classified as Class I. Their proprietary AI platform underpins a range of therapeutic interventions, addressing issues such as obesity, breast cancer, and nicotine addiction. By combining psychology, design, and technology, Alex provides personalized self-healthcare solutions that aim to transform the support clinicians offer to patients seeking to improve their health outcomes.

Alex Health AB, based in Stockholm, is an innovative startup focused on leveraging artificial intelligence and psychology to enhance mental health through behavioral change. Founded in 2017, the company is currently developing a second-generation behavioral change application aimed at helping one billion people overcome detrimental habits. Alex specializes in creating evidence-based digital therapeutics and software medical devices, which are CE-marked and classified as Class I. Their proprietary AI platform underpins a range of therapeutic interventions, addressing issues such as obesity, breast cancer, and nicotine addiction. By combining psychology, design, and technology, Alex provides personalized self-healthcare solutions that aim to transform the support clinicians offer to patients seeking to improve their health outcomes.

TargED Biopharmaceuticals is a biotechnology company focused on developing innovative biological drugs aimed at enhancing the treatment of thrombosis. The company utilizes small antibodies, known as VhH, to deliver enzymes directly to the sites of thrombus, facilitating targeted thrombolysis. This approach allows for effective treatment regardless of the blood clot's composition, thereby enabling healthcare professionals to accelerate patient care and improve outcomes for those affected by thrombosis.

Ribbon Biolabs GmbH is a Vienna, Austria-based company founded in 2018 that specializes in the synthesis of long DNA molecules. The company aims to advance molecular biology by developing innovative methods for DNA synthesis, enabling the creation and exploration of genetic solutions through high-throughput synthesis of unprecedentedly long DNA sequences. Ribbon Biolabs' technology supports a wide range of applications, including genome construction, high-throughput libraries, DNA-based data storage and computing, and the development of DNA nanotechnologies. This allows researchers and companies to work with extensive DNA libraries without economic or time constraints.

Emergence Therapeutics AG is a biopharmaceutical company based in Duisburg, Germany, focused on developing innovative antibody-drug conjugates (ADCs) to address high-need cancers. Established in 2019, the company leverages advanced technologies in antibody design, linker systems, and therapeutic payloads to create targeted treatments. Its lead program specifically targets Nectin-4, a clinically validated marker for various cancers, utilizing a highly specific antibody in combination with optimized linker technology and amanitin as the payload. This approach aims to provide effective therapeutic options for challenging cancer types. Emergence Therapeutics is also exploring opportunities to develop additional first- or best-in-class ADCs to meet unmet medical needs in oncology.

Cardior Pharmaceuticals GmbH is a biotechnology company based in Hanover, Germany, founded in 2016. The company specializes in developing non-coding RNA-based therapeutics aimed at treating and preventing heart disease, which is the leading cause of death in the western world. Its primary focus is on CDR-132X, an oligonucleotide-based inhibitor that targets a critical microRNA responsible for pathological changes in the heart resulting from stress or injury. Through its innovative approach, Cardior Pharmaceuticals seeks to address significant unmet medical needs in cardiovascular health.

Oncoinvent AS is a pharmaceutical company focused on developing innovative cancer treatments. By leveraging established physical and chemical principles of novel materials, Oncoinvent aims to enhance the medical benefits of its products while addressing safety concerns. The company is dedicated to creating effective treatment options for cancer patients, contributing to advancements in healthcare and improving patient outcomes. Through its research and development efforts, Oncoinvent seeks to provide convalescent therapies that meet the needs of the healthcare sector.

SAGA Diagnostics AB is a Swedish company specializing in personalized cancer diagnostics and disease monitoring through molecular genetic analyses, focusing on circulating tumor DNA (ctDNA). Founded in 2016 as a spin-out from a research group at Lund University, SAGA aims to enhance precision cancer medicine and improve patient survival rates with its minimally-invasive liquid biopsy testing services. The company provides a range of services, including gene mutation analysis and treatment monitoring, utilizing advanced technologies such as massively parallel sequencing. SAGA's proprietary tests enable oncologists and biopharmaceutical companies to detect actionable mutations, stratify patient groups, and monitor treatment responses with high sensitivity, thereby contributing significantly to advancements in cancer research and clinical diagnostics.

Step Pharma, incorporated in 2014 and based in Paris, France, focuses on developing innovative drugs for immunosuppressive therapies aimed at treating autoimmune diseases. As a spin-off of the Imagine Institute, the company emerged from research led by Pr. Alain Fischer on genetic immunodeficiencies. It operates as a joint venture with Sygnature Discovery, which provides integrated drug discovery resources, and Kurma Partners, a prominent investor in European healthcare and biotechnology. Step Pharma's proprietary small molecule therapeutics utilize a novel class of oral nucleotide synthesis inhibitors that target cytidine triphosphate synthase 1. This approach allows for the selective modulation of immune cell populations, such as T and B cells, enhancing treatment efficacy and therapeutic outcomes for patients with autoimmune conditions.

Pipeline Therapeutics Inc. is a biotechnology company based in San Diego, California, specializing in the development and commercialization of small molecules aimed at neuroregeneration. Founded in 2017, the company focuses on promoting functional recovery for various neurological disorders. Its lead product candidate, PIPE-505, is a small molecule gamma secretase inhibitor designed to treat mild-to-moderate sensorineural hearing loss associated with cochlear synaptopathy. Additionally, Pipeline Therapeutics has a portfolio of earlier-stage programs, including PIPE-307, which targets remyelination and axonal repair to address conditions like multiple sclerosis. By harnessing the natural repair processes of different nervous system cell types, the company seeks to provide innovative treatments that repair damage within the nervous system.

CardioMech is a medical device company specializing in the development of innovative therapeutic technologies for structural heart disease. Founded in 2015 and based in Trondheim, Norway, CardioMech focuses on providing a transcatheter alternative to traditional cardiac surgery for the placement of artificial chords in the mitral valve. This catheter-based approach is designed to treat patients suffering from severe symptomatic degenerative mitral regurgitation due to conditions such as prolapse or flail. By enabling surgeons to perform these procedures without the need for open-heart surgery, chest incisions, or heart-lung bypass, CardioMech aims to enhance treatment options for patients with moderate to severe mitral regurgitation.

Gesynta Pharma AB is a clinical-stage pharmaceutical company based in Stockholm, Sweden, founded in 2017. The company focuses on developing compounds that inhibit the pro-inflammatory enzyme microsomal prostaglandin E synthase-1 (mPGES-1) to address chronic inflammatory conditions, particularly in cardiovascular diseases and cancer. Its most advanced drug candidate, vipoglanstat (GS-248), is being developed as a non-hormonal treatment for endometriosis, a painful condition affecting around 10 percent of women of reproductive age. Clinical studies have indicated that vipoglanstat significantly reduces endometriotic lesions and provides pain relief, with preparations underway for a phase II clinical trial. Additionally, Gesynta Pharma is advancing another candidate, GS-073, which is set to enter phase I clinical trials for a different inflammatory condition. The company's research is rooted in work from the Karolinska Institutet, and it aims to deliver safe and effective treatments for serious diseases.

Oncoinvent AS is a pharmaceutical company focused on developing innovative cancer treatments. By leveraging established physical and chemical principles of novel materials, Oncoinvent aims to enhance the medical benefits of its products while addressing safety concerns. The company is dedicated to creating effective treatment options for cancer patients, contributing to advancements in healthcare and improving patient outcomes. Through its research and development efforts, Oncoinvent seeks to provide convalescent therapies that meet the needs of the healthcare sector.

Neuro Event Labs Oy, established in 2015 and headquartered in Tampere, Finland, specializes in developing artificial intelligence-based software for epilepsy patient monitoring. Their primary product collects accurate seizure data from patients at home and in hospitals, which is then analyzed and relayed to physicians for informed treatment decisions. This solution was developed in close collaboration with leading Finnish hospitals.

Abliva AB is a Swedish pharmaceutical company focused on the research and development of treatments for primary mitochondrial diseases, which are rare and severe conditions caused by dysfunctional mitochondria. The company's pipeline includes KL1333, currently in phase I clinical trials, and NV354, an energy replacement therapy that is preparing for clinical trials. KL1333 is noted for its role as a regulator of NAD+ and NADH, and has received orphan drug designation in both Europe and the United States. Additionally, Abliva is developing NeuroSTAT for the treatment of traumatic brain injury. Established in 2000 and headquartered in Lund, Sweden, Abliva has formed collaborations with various institutions, enhancing its research capabilities and clinical development efforts.

Pipeline Therapeutics Inc. is a biotechnology company based in San Diego, California, specializing in the development and commercialization of small molecules aimed at neuroregeneration. Founded in 2017, the company focuses on promoting functional recovery for various neurological disorders. Its lead product candidate, PIPE-505, is a small molecule gamma secretase inhibitor designed to treat mild-to-moderate sensorineural hearing loss associated with cochlear synaptopathy. Additionally, Pipeline Therapeutics has a portfolio of earlier-stage programs, including PIPE-307, which targets remyelination and axonal repair to address conditions like multiple sclerosis. By harnessing the natural repair processes of different nervous system cell types, the company seeks to provide innovative treatments that repair damage within the nervous system.

Themis Bioscience N.V. is a clinical-stage biopharmaceutical company headquartered in Vienna, Austria, specializing in immunomodulation to develop products aimed at protecting against infectious diseases. Founded in 2009, the company’s lead product candidate, MV-CHIK, has completed Phase II clinical trials for chikungunya treatment. Themis is also engaged in developing vaccines for various health threats, including cancer, Zika virus, Lassa fever, and MERS. Themis leverages its advanced understanding of immune system mechanisms through its innovative vaccine platform, focusing on both emerging and specialized indications. The company has established research collaborations and exclusive licensing agreements to enhance its development capabilities, positioning itself as a strategic partner for leading biotechnology and pharmaceutical firms.

SAGA Diagnostics AB is a Swedish company specializing in personalized cancer diagnostics and disease monitoring through molecular genetic analyses, focusing on circulating tumor DNA (ctDNA). Founded in 2016 as a spin-out from a research group at Lund University, SAGA aims to enhance precision cancer medicine and improve patient survival rates with its minimally-invasive liquid biopsy testing services. The company provides a range of services, including gene mutation analysis and treatment monitoring, utilizing advanced technologies such as massively parallel sequencing. SAGA's proprietary tests enable oncologists and biopharmaceutical companies to detect actionable mutations, stratify patient groups, and monitor treatment responses with high sensitivity, thereby contributing significantly to advancements in cancer research and clinical diagnostics.

Nisonic is a medical technology company focused on developing innovative products for the non-invasive diagnosis and monitoring of increased intracranial pressure (ICP). The company's advanced ultrasound technology utilizes an optimized transducer for transorbital imaging and employs machine-learning algorithms to provide automatic measurements and guidance for accurate probe positioning. This approach enables medical professionals in emergency departments, intensive care units, and critical care settings to detect ICP early and intervene effectively, thereby reducing the reliance on invasive methods that carry risks of complications and are limited to larger hospitals. By integrating their software with existing ultrasound devices, Nisonic aims to enhance the accessibility and cost-effectiveness of ICP monitoring, ultimately improving patient outcomes and lowering mortality and disability rates associated with elevated intracranial pressure.

Attgeno is a pharmaceutical company focused on developing innovative treatments for acute life-threatening conditions. The company's primary offering is a nitric oxide-donating drug that aims to address acute pulmonary hypertension by selectively lowering blood pressure in the lungs. This drug utilizes unique nitric oxide-containing compounds that effectively penetrate the bloodstream and facilitate the dilation of blood vessels in the lungs. By enabling the extension of these blood vessels, Attgeno's treatment aims to provide healthcare professionals with a critical tool to manage and alleviate the serious risks associated with elevated lung pressure in patients.