Intersouth Partners, established in 1985 and headquartered in Durham, North Carolina, is a prominent venture capital firm focusing on seed and early-stage investments in the technology and life sciences sectors. The firm prefers to invest in software, semiconductor, communications, digital media, clean technology, and security companies within the technology sector, and medical devices, biopharmaceuticals, agricultural biotechnology, and biomaterials within life sciences. Intersouth typically invests in companies located across the Southeast, with a primary focus on the corridor from Baltimore through Florida, including Washington, DC, the Research Triangle region, and Atlanta. The firm seeks to be the lead or co-lead investor, with an initial investment ranging from $0.5 million to $8 million, and plans for an average total investment of $12 million through all rounds of financing. Intersouth aims to take a board seat on its portfolio companies and prefers to exit its investments within two to six years.
Advanced Animal Diagnostics, Inc. focuses on the research, development, and commercialization of on-farm diagnostic tools aimed at the early detection of subclinical mastitis in dairy cows. Based in Durham, North Carolina, the company offers products such as the QScout Farm Lab, an analyzer system that identifies infections in dairy cows before symptoms manifest, and the QScout Milk Leukocyte Differential rapid test, which analyzes milk to detect and differentiate white blood cells indicative of mastitis. Additionally, Advanced Animal Diagnostics provides solutions like QuickSmear, a rapid differential slide that aids in animal research, and the SCC+ System for early mastitis detection. These diagnostic tools are designed to enhance animal health management, benefiting veterinarians and livestock producers by enabling timely detection of infections and supporting informed treatment decisions. Founded in 2001, the company aims to improve the overall health and productivity of production animals.
Vascular Pharmaceuticals
Series A in 2015
Vascular Pharmaceuticals, Inc. is a biopharmaceutical company focused on developing therapeutics for patients with type 1 and type 2 diabetes, specifically targeting complications such as diabetic nephropathy. Founded in 2005 and based in North Carolina, the company is advancing its lead candidate, VPI-2690B, a subcutaneously administered monoclonal antibody designed to respond to hyperglycemia. This innovative treatment aims to bind to a specific molecular target within the αVβ3 receptor, potentially offering patients a means to mitigate the serious complications associated with diabetes. Vascular Pharmaceuticals operates at the intersection of biotechnology, medicine, and healthcare, contributing to the ongoing efforts to improve outcomes for those affected by diabetes.
Zenph
Debt Financing in 2013
Learn to play the music you love in the Zenph Online Education Network (ZOEN). We deliver the perfect match between teachers and students through live online music lessons. Whether you’re looking to learn your favorite song, seeking advice on perfecting your technique or searching for the right music teacher for your kids, taking a live online music lesson from one of the ZOEN’s experienced, nationally renowned music teachers is just a matter of a few clicks! The ZOEN is brought to you by Zenph, Inc. – our award winning Re-Performance® technology was named one of the “Best Ideas of the Year” by The New York Times Magazine and has earned us accolades from music lovers and critics the world over, including multiple GRAMMY® nominations. Based in North Carolina’s Research Triangle Park, we are a venture-backed technology company led by a team of music and software professionals with expertise in music education, consumer software, social gaming and entertainment.
Argos Therapeutics
Series E in 2013
Argos Therapeutics, Inc. was a biotechnology company based in Durham, North Carolina, focused on developing personalized immunotherapies for cancer, infectious diseases, and autoimmune disorders. It utilized its proprietary Arcelis technology platform to create individualized treatments, including rocapuldencel-T, which was undergoing Phase III clinical trials for metastatic renal cell carcinoma, and AGS-004, in Phase II trials for human immunodeficiency virus. The company's product pipeline also included therapies aimed at transplant rejection and autoimmune conditions. Founded in 1997 and originally named Merix Bioscience, Argos Therapeutics aimed to address significant unmet medical needs in the field of immuno-oncology. However, on September 24, 2019, the company filed for Chapter 7 bankruptcy, leading to its cessation of operations.
Argos Therapeutics
Series E in 2013
Argos Therapeutics, Inc. was a biotechnology company based in Durham, North Carolina, focused on developing personalized immunotherapies for cancer, infectious diseases, and autoimmune disorders. It utilized its proprietary Arcelis technology platform to create individualized treatments, including rocapuldencel-T, which was undergoing Phase III clinical trials for metastatic renal cell carcinoma, and AGS-004, in Phase II trials for human immunodeficiency virus. The company's product pipeline also included therapies aimed at transplant rejection and autoimmune conditions. Founded in 1997 and originally named Merix Bioscience, Argos Therapeutics aimed to address significant unmet medical needs in the field of immuno-oncology. However, on September 24, 2019, the company filed for Chapter 7 bankruptcy, leading to its cessation of operations.
Advanced Animal Diagnostics
Series B in 2013
Advanced Animal Diagnostics, Inc. focuses on the research, development, and commercialization of on-farm diagnostic tools aimed at the early detection of subclinical mastitis in dairy cows. Based in Durham, North Carolina, the company offers products such as the QScout Farm Lab, an analyzer system that identifies infections in dairy cows before symptoms manifest, and the QScout Milk Leukocyte Differential rapid test, which analyzes milk to detect and differentiate white blood cells indicative of mastitis. Additionally, Advanced Animal Diagnostics provides solutions like QuickSmear, a rapid differential slide that aids in animal research, and the SCC+ System for early mastitis detection. These diagnostic tools are designed to enhance animal health management, benefiting veterinarians and livestock producers by enabling timely detection of infections and supporting informed treatment decisions. Founded in 2001, the company aims to improve the overall health and productivity of production animals.
Vascular Pharmaceuticals
Series A in 2012
Vascular Pharmaceuticals, Inc. is a biopharmaceutical company focused on developing therapeutics for patients with type 1 and type 2 diabetes, specifically targeting complications such as diabetic nephropathy. Founded in 2005 and based in North Carolina, the company is advancing its lead candidate, VPI-2690B, a subcutaneously administered monoclonal antibody designed to respond to hyperglycemia. This innovative treatment aims to bind to a specific molecular target within the αVβ3 receptor, potentially offering patients a means to mitigate the serious complications associated with diabetes. Vascular Pharmaceuticals operates at the intersection of biotechnology, medicine, and healthcare, contributing to the ongoing efforts to improve outcomes for those affected by diabetes.
Argos Therapeutics
Series D in 2012
Argos Therapeutics, Inc. was a biotechnology company based in Durham, North Carolina, focused on developing personalized immunotherapies for cancer, infectious diseases, and autoimmune disorders. It utilized its proprietary Arcelis technology platform to create individualized treatments, including rocapuldencel-T, which was undergoing Phase III clinical trials for metastatic renal cell carcinoma, and AGS-004, in Phase II trials for human immunodeficiency virus. The company's product pipeline also included therapies aimed at transplant rejection and autoimmune conditions. Founded in 1997 and originally named Merix Bioscience, Argos Therapeutics aimed to address significant unmet medical needs in the field of immuno-oncology. However, on September 24, 2019, the company filed for Chapter 7 bankruptcy, leading to its cessation of operations.
Advanced Animal Diagnostics
Series B in 2012
Advanced Animal Diagnostics, Inc. focuses on the research, development, and commercialization of on-farm diagnostic tools aimed at the early detection of subclinical mastitis in dairy cows. Based in Durham, North Carolina, the company offers products such as the QScout Farm Lab, an analyzer system that identifies infections in dairy cows before symptoms manifest, and the QScout Milk Leukocyte Differential rapid test, which analyzes milk to detect and differentiate white blood cells indicative of mastitis. Additionally, Advanced Animal Diagnostics provides solutions like QuickSmear, a rapid differential slide that aids in animal research, and the SCC+ System for early mastitis detection. These diagnostic tools are designed to enhance animal health management, benefiting veterinarians and livestock producers by enabling timely detection of infections and supporting informed treatment decisions. Founded in 2001, the company aims to improve the overall health and productivity of production animals.
Semprius
Venture Round in 2012
Semprius, Inc. is a company focused on the design, development, and manufacture of high concentration photovoltaic (HCPV) solar modules aimed at generating solar energy. Based in Durham, North Carolina, Semprius utilizes a unique micro-transfer printing technology that enables the production of high-performance and reliable CPV modules at a low cost, making solar power generation economically feasible in sunny and arid climates. The company’s products are targeted for utility, commercial, industrial, and government applications and are distributed through integrators and engineering, procurement, and construction (EPC) firms. In addition to its solar applications, Semprius is licensing its micro-transfer printing technology for non-solar uses, which can facilitate the development of innovative products such as flat-panel displays, flexible electronics, and large-area sensors. Founded in 2005, Semprius continues to advance its technology to enable scalable production and broad applications in the semiconductor industry.
Semprius
Series C in 2011
Semprius, Inc. is a company focused on the design, development, and manufacture of high concentration photovoltaic (HCPV) solar modules aimed at generating solar energy. Based in Durham, North Carolina, Semprius utilizes a unique micro-transfer printing technology that enables the production of high-performance and reliable CPV modules at a low cost, making solar power generation economically feasible in sunny and arid climates. The company’s products are targeted for utility, commercial, industrial, and government applications and are distributed through integrators and engineering, procurement, and construction (EPC) firms. In addition to its solar applications, Semprius is licensing its micro-transfer printing technology for non-solar uses, which can facilitate the development of innovative products such as flat-panel displays, flexible electronics, and large-area sensors. Founded in 2005, Semprius continues to advance its technology to enable scalable production and broad applications in the semiconductor industry.
Advanced Animal Diagnostics
Series B in 2011
Advanced Animal Diagnostics, Inc. focuses on the research, development, and commercialization of on-farm diagnostic tools aimed at the early detection of subclinical mastitis in dairy cows. Based in Durham, North Carolina, the company offers products such as the QScout Farm Lab, an analyzer system that identifies infections in dairy cows before symptoms manifest, and the QScout Milk Leukocyte Differential rapid test, which analyzes milk to detect and differentiate white blood cells indicative of mastitis. Additionally, Advanced Animal Diagnostics provides solutions like QuickSmear, a rapid differential slide that aids in animal research, and the SCC+ System for early mastitis detection. These diagnostic tools are designed to enhance animal health management, benefiting veterinarians and livestock producers by enabling timely detection of infections and supporting informed treatment decisions. Founded in 2001, the company aims to improve the overall health and productivity of production animals.
Semprius
Series B in 2009
Semprius, Inc. is a company focused on the design, development, and manufacture of high concentration photovoltaic (HCPV) solar modules aimed at generating solar energy. Based in Durham, North Carolina, Semprius utilizes a unique micro-transfer printing technology that enables the production of high-performance and reliable CPV modules at a low cost, making solar power generation economically feasible in sunny and arid climates. The company’s products are targeted for utility, commercial, industrial, and government applications and are distributed through integrators and engineering, procurement, and construction (EPC) firms. In addition to its solar applications, Semprius is licensing its micro-transfer printing technology for non-solar uses, which can facilitate the development of innovative products such as flat-panel displays, flexible electronics, and large-area sensors. Founded in 2005, Semprius continues to advance its technology to enable scalable production and broad applications in the semiconductor industry.
Argos Therapeutics
Series C in 2008
Argos Therapeutics, Inc. was a biotechnology company based in Durham, North Carolina, focused on developing personalized immunotherapies for cancer, infectious diseases, and autoimmune disorders. It utilized its proprietary Arcelis technology platform to create individualized treatments, including rocapuldencel-T, which was undergoing Phase III clinical trials for metastatic renal cell carcinoma, and AGS-004, in Phase II trials for human immunodeficiency virus. The company's product pipeline also included therapies aimed at transplant rejection and autoimmune conditions. Founded in 1997 and originally named Merix Bioscience, Argos Therapeutics aimed to address significant unmet medical needs in the field of immuno-oncology. However, on September 24, 2019, the company filed for Chapter 7 bankruptcy, leading to its cessation of operations.
Semprius
Series A in 2007
Semprius, Inc. is a company focused on the design, development, and manufacture of high concentration photovoltaic (HCPV) solar modules aimed at generating solar energy. Based in Durham, North Carolina, Semprius utilizes a unique micro-transfer printing technology that enables the production of high-performance and reliable CPV modules at a low cost, making solar power generation economically feasible in sunny and arid climates. The company’s products are targeted for utility, commercial, industrial, and government applications and are distributed through integrators and engineering, procurement, and construction (EPC) firms. In addition to its solar applications, Semprius is licensing its micro-transfer printing technology for non-solar uses, which can facilitate the development of innovative products such as flat-panel displays, flexible electronics, and large-area sensors. Founded in 2005, Semprius continues to advance its technology to enable scalable production and broad applications in the semiconductor industry.
6th Sense Analytics
Series A in 2007
6th Sense Analytics provides software solutions for automated collection and analysis of software engineering process and product data. The company was founded in 2004 and is based in Morrisville, North Carolina. As of January 12, 2009, 6th Sense Analytics operates as a subsidiary of Rally Software Development Corp.
Nitronex
Venture Round in 2006
Nitronex is a leading company in the development and manufacturing of gallium nitride-on-silicon (GaN-on-Si) RF power devices. Founded in 1999 by graduates from North Carolina State University's wide bandgap program, the company is headquartered in Durham, North Carolina. Nitronex specializes in GaN semiconductors, which are utilized in various applications, including wireless communications, solid-state lighting, and data storage. The company produces RF power transistors specifically designed for wireless infrastructure, broadband, and military markets. Nitronex holds 21 patents and has an additional 17 patents pending, underscoring its commitment to innovation in high-performance semiconductor technology.
HexaTech
Series A in 2005
HexaTech, Inc. specializes in the development and commercialization of advanced semiconductor materials, particularly single-crystalline aluminum nitride (AlN) substrates. The company's products enable the creation of innovative devices, including ultraviolet (UV-C) light emitting diodes and lasers, which are essential for applications in disinfection, sterilization, and biological threat detection. Additionally, HexaTech focuses on high voltage and high frequency semiconductor devices, catering to the needs of the biotechnology and pharmaceutical sectors. Established in 2001 and headquartered in Morrisville, North Carolina, HexaTech is committed to providing high-performance solutions that enhance efficiency in power conversion and contribute to the advancement of electronic and optoelectronic technologies.
6th Sense Analytics
Venture Round in 2005
6th Sense Analytics provides software solutions for automated collection and analysis of software engineering process and product data. The company was founded in 2004 and is based in Morrisville, North Carolina. As of January 12, 2009, 6th Sense Analytics operates as a subsidiary of Rally Software Development Corp.
Jaggaer
Venture Round in 2004
Jaggaer, LLC is a cloud-based software company that specializes in procurement automation and spend management solutions. Founded in 1995 and headquartered in Morrisville, North Carolina, Jaggaer offers a comprehensive suite of tools for organizations to streamline their purchasing processes, manage supplier relationships, and analyze spending data. Its key products include Sourcing Manager for bid management, Eprocurement solutions for procurement automation, and Spend Analytics for data-driven cost management. Additionally, Jaggaer provides inventory management and invoicing solutions, enhancing overall operational efficiency. The company's services are delivered through a software-as-a-service model, ensuring scalability and accessibility for its diverse client base, which includes sectors such as higher education, healthcare, and government. Jaggaer's platform aims to reduce costs, improve collaboration with suppliers, and optimize supply chain resilience.
StemCo Biomedical
Series B in 2003
StemCo Biomedical, Inc. was founded in 1999 and is located in the Research Triangle Park area of NC. The Company is engaged in the development, manufacture and distribution of a series of medical products designed to improve therapeutic transplantation of adult hematopoetic stem and progenitor cells derived from bone marrow, peripheral blood or umbilical cord blood. Addressing a market of more than $1 billion annually, the Company will have a series of products on the market starting in 2002 that identify, sort and custom-engineer stem cell grafts based upon cellular expression of ALDH resulting in what may be better, more effective stem cell transplants in the future.
Norak Biosciences
Series B in 2002
Norak Biosciences, Inc., headquartered in Research Triangle Park, NC, is a private biotechnology company. Norak is utilizing its proprietary Transfluor technology to become a world leader in the discovery and development of drugs that regulate G protein-coupled receptors.
StemCo Biomedical
Series A in 2000
StemCo Biomedical, Inc. was founded in 1999 and is located in the Research Triangle Park area of NC. The Company is engaged in the development, manufacture and distribution of a series of medical products designed to improve therapeutic transplantation of adult hematopoetic stem and progenitor cells derived from bone marrow, peripheral blood or umbilical cord blood. Addressing a market of more than $1 billion annually, the Company will have a series of products on the market starting in 2002 that identify, sort and custom-engineer stem cell grafts based upon cellular expression of ALDH resulting in what may be better, more effective stem cell transplants in the future.
Accordant Health Services
Venture Round in 2000
Accordant provides its program members with healthcare advice. The service focuses on delivering support for patients with rare, chronic diseases. Its care management solutions comprise of tools and resources of professionals in the healthcare sector. The service also delivers care management services for rare diseases which include health plans, employers, and third party administrators. Accordant is a subsidiary of CVS Caremark. It was founded by Steve Schelhammer and is headquartered in Greensboro, North Carolina.
Accipiter
Series A in 1997
Accipiter offers online advertising solutions and services worldwide. It offers AdManager, an ad management solution that allows to increase targeting capabilities to speed ad delivery and to monitor and control inventory projections in real-time; Ad Trafficking, which provides AdManager hosted clients with outsourced and customized solution to administer the campaign management process; AdMarket, a real-time bid-for-placement technology enabling publishers to operate branded online advertising marketplaces and transact with advertisers who are requesting a pay-per-click pricing model; and Visitor Interest Behavioral Engine, a behavioral targeting solution that delivers promotions and content to interested prospects. Accipiter is based in Raleigh, North Carolina with an additional office in London, United Kingdom.
Accipiter
Seed Round in 1996
Accipiter offers online advertising solutions and services worldwide. It offers AdManager, an ad management solution that allows to increase targeting capabilities to speed ad delivery and to monitor and control inventory projections in real-time; Ad Trafficking, which provides AdManager hosted clients with outsourced and customized solution to administer the campaign management process; AdMarket, a real-time bid-for-placement technology enabling publishers to operate branded online advertising marketplaces and transact with advertisers who are requesting a pay-per-click pricing model; and Visitor Interest Behavioral Engine, a behavioral targeting solution that delivers promotions and content to interested prospects. Accipiter is based in Raleigh, North Carolina with an additional office in London, United Kingdom.
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