Leaps by Bayer

Dewpoint Therapeutics, Inc., a biotech company, engages in research of biomolecular condensates and cellular function to develop treatments for diseases like cancer, neurodegenerative disorders, immunology, cardiovascular, women’s health, and virology. The company was incorporated in 2018 and is based in Boston, Massachusetts.

Senti Biosciences is a team of bioengineers, scientists, and entrepreneurs on a mission to treat the most complex and challenging diseases. Led by pioneers in synthetic biology and computation, Senti is using the latest techniques in the fields to build the future of gene and cell-based therapies. Senti’s proprietary synthetic biology platform provides fundamental advantages for therapeutics development. Senti Biosciences is a resident company of Johnson & Johnson Innovation, JLABS at South San Francisco (JLABS @ SSF).

Transcarent is a consumer digital health company, uses a combination of software, technology, and data science to empower consumers with information and access, leading to better outcomes and more cost-effective decisions. We believe that having the right information, tools, and incentives in the decision-making process can be positively transformative in the way we all experience healthcare.

Century Therapeutics, Inc. engages in the development of induced pluripotent stem cell- (iPSC) based drugs for the treatment of hematologic and solid malignancies. The use of iPSC enables multiple rounds of cellular engineering to produce master cell banks of modified cells that can be expanded and differentiated into immune effector cells to supply allogeneic, homogeneous therapeutic products. The company was founded in 2018 and is based in Philadelphia, Pennsylvania.

Apollo helps farmers in emerging markets maximize their profits. We use agronomic machine learning, remote sensing, and mobile phones to deliver a customized package of credit, high-quality farm inputs, and advice that can double farm yields, starting in Kenya. Apollo assesses farmer credit risk and customizes each package to a farmer's specific location using satellite data, soil data, farmer behavior data and crop yield models. Our team team brings together tech and operations experience from The Climate Corporation (acquired for ~$1B), Tesla, and One Acre Fund.

NewLeaf Symbiotics develops and commercializes the bacteria found in Pink Pigmented Facultative Methylotrophs. NewLeaf Symbiotics has also filed its own related patents and is actively developing new technologies related to PPFMs. The Company is engaged in laboratory, greenhouse, and field product trials and expects to commercialize and license products beginning in 2014.

Edifice Health is a spin-out company from a 10-year research study on immune profiling from Stanford University, the Stanford 1,000 Immunomes Project. The technology is the first biomarker composite scoring system to measure immune health and the Inflammatory Age® of an individual which predicts the onset of multiple chronic diseases and provides comprehensive health insights designed to help people change the course of their aging process.

ChrysaLabs develops a portable probe that can measure in real-time soil nutrients and soil health for producers and agronomists. It also develops a management platform which enables workers to access data and take action. The company was founded in 2017 and is based in Montreal, Canada.

Senti Biosciences is a team of bioengineers, scientists, and entrepreneurs on a mission to treat the most complex and challenging diseases. Led by pioneers in synthetic biology and computation, Senti is using the latest techniques in the fields to build the future of gene and cell-based therapies. Senti’s proprietary synthetic biology platform provides fundamental advantages for therapeutics development. Senti Biosciences is a resident company of Johnson & Johnson Innovation, JLABS at South San Francisco (JLABS @ SSF).

Cellino Biotech develops intracellular delivery lasers and nanotechnology for gene editing applications. The company makes stem cell differentiation a digital process, applying the latest tools from optics, biology, and computation to engineer functionally mature cells. Its technology enables the acceleration of the development time of engineered cells from years to weeks.

Metagenomi, Inc. develops gene editing systems for the treatment of genetic diseases. The company was incorporated in 2016 and is based in Emeryville, California.

GRO Biosciences is leveraging breakthrough technologies from computational protein design and synthetic biology to develop best-in-class protein therapeutics with enhanced properties. The company has established multiple genomically recoded strains of bacteria that can incorporate non-standard amino acids into proteins to confer increased potency, stability, and targeted delivery. GRO Biosciences is applying its technology platform to develop improved protein therapeutics for diabetes, growth disorders and autoimmunity. The company, co-founded by Dr. George Church, is located at the Harvard Life Lab, a shared laboratory space for high-potential life sciences and biotechnology startups founded by Harvard faculty, alumni, students, and postdoctoral scholars.

Bloom Science, Inc. develops neuroprotective medicine that uses microbiome to cure people with epilepsy and other neurological conditions. The company was incorporated in 2017 and is based in San Diego, California.

MedArrive, Inc. owns and operates a software-as-a-service technology health platform. It enables healthcare providers to extend care services through integrated care management platform. It also integrates clinical data into electronic medical records software and provides communication and billing capabilities. The company is based in New York, New York.

Huma is a global health tech company with a mission to help people with chronic, complex, and rare diseases to live longer, better lives. Huma works with world-leading healthcare providers, pharmaceutical, insurance and technology companies, including Apple and Tencent, to build a connected digital health ecosystem. Headquartered in London, Medopad has offices in the US and China.

Senti Biosciences is a team of bioengineers, scientists, and entrepreneurs on a mission to treat the most complex and challenging diseases. Led by pioneers in synthetic biology and computation, Senti is using the latest techniques in the fields to build the future of gene and cell-based therapies. Senti’s proprietary synthetic biology platform provides fundamental advantages for therapeutics development. Senti Biosciences is a resident company of Johnson & Johnson Innovation, JLABS at South San Francisco (JLABS @ SSF).

Guardian Agriculture has developed an integrated eVTOL (electric vertical takeoff and landing) system for precision application, extending growers’ reach, reducing environmental impact, and minimizing product resistance. Offered as a service, the company’s autonomous, eVTOL, agricultural systems collect and act intelligently on data generated throughout the crop protection process. When deployed at scale the systems are capable of eliminating hundreds of millions of pounds of unnecessary pesticide use annually while helping farmers grow healthier, better-protected crops.

9am.health redesigns all care elements into one digital service individualized around today’s reality of people’s life - always available and convenient, at prices anyone can afford even without insurance. 9am.health focuses on chronic conditions such as diabetes, hypertension, and hyperlipidemia for customers in the United States.

Woebot Health’s mission is to make mental health radically accessible. Our breakthrough technology is engineered to engage, bringing the art and science of effective therapy together in a suite of digital therapeutics and behavioral health products that are related, responsive and targeted, Headquartered in San Francisco, Woebot Health is funded in part by venture capital firms New Enterprise Associates (NEA), Jazz Venture Partners L.P., and Social Discovery Ventures, with participation from Andrew Ng’s AI Fund.

Clarify Medical, Inc. develops home therapy solutions for chronic skin treatments. It offers The Clarify mobile ultra violet B treatment system, an investigational device for use in treating plaque psoriasis, eczema, and vitiligo; and Home Light Therapy System, a home phototherapy system for the treatment of psoriasis, vitiligo, and eczema. Clarify Medical, Inc. was formerly known as Skylit Medical, Inc. and changed its name to Clarify Medical, Inc. in September 2016. The company was incorporated in 2014 and is based in San Diego, California.

Triumvira Immunologics, Inc. (“Triumvira”) is an immunotherapy company co-founded in 2015 by Dr. Jonathan Bramson at McMaster University and Bloom Burton & Co., with the vision of developing novel T cell therapies that are safer and more efficacious than current cancer treatments, including chimeric antigen receptor (CAR) and engineered T cell receptor (TCR) therapies. Their proprietary T cell Antigen Coupler (TAC) technology recruits the entire natural T cell receptor and is independent of the major histocompatibility complex (MHC), allowing for the development of better therapies for a broader range of patients with solid or liquid malignancies and also with diseases other than cancer.

ReCode Therapeutics is a development-stage biopharmaceutical company focused on the correction of the nonsense mutations that account for 1/3 of all inherited diseases, including approximately 10% of cystic fibrosis. They have combined selected tRNAs with their unique and diverse proprietary delivery platforms to create and develop first-in-class suppressor tRNA-nanoparticle therapeutics for correcting nonsense mutations. ReCode’s diverse pipeline includes lead programs for primary ciliary dyskinesia (PCD) and nonsense mutations in cystic fibrosis (CF). The company’s proprietary non-viral lipid nanoparticle platform enables the delivery of a variety of payloads, and precise organ targeting of nucleic acid and protein payloads via both systemic and local delivery. ReCode is leveraging its nanoparticle and nucleic acid technologies across multiple modalities, including mRNA-mediated protein replacement therapies, first-in-class tRNA NanoCorrectors for diseases caused by nonsense mutations, and gene editing. The company was founded in 2015 and is based in Dallas, Texas.

Andes develops technologies for a more sustainable and efficient agriculture. Our solutions are based on beneficial microbes that have naturally co-evolved through thousands of years with plants. Microbe-based formulations are customized through scientific research and an advanced predictive software using Artificial Intelligence. Our technology will allow farmers to have better yields, grow their crops faster, cultivate on traditionally unsuitable lands, use less fertilizers and pesticides, and successfully face the challenges of global climate change. Microbe-based solutions have the potential to foster a new green revolution in a healthy, responsible and environmentally friendly way, and Andes plays a key role in this transformation.

Early stage biotechnology start-up developing next generation cytokine therapeutics

Metagenomi, Inc. develops gene editing systems for the treatment of genetic diseases. The company was incorporated in 2016 and is based in Emeryville, California.

Sound Agriculture uses molecular discovery to create climate-resilient crops, enhancing harvest yields for growers. They also use an innovative life science approach to sustainably increase farming productivity. The company was founded in 2013 and headquartered in Emeryville, California.

Vivante Health, Inc., a digital health company, develops solutions to manage chronic conditions. It offers GIThrive, a technology platform that provides actionable insights to members manage their digestive conditions, as well as empowers people through technology, advanced science, and on-demand human support for cost savings for health plans and self-insured employers. The company’s GIThrive also acts as a digital gut health program that provides expert insights and guidance, monitoring and analysis, and 24/7 gut-side assistance. In addition, it offers GIMate, a portable breathalyzer that identifies trigger food; and GutCheck, an at-home microbiome analysis of gut bacteria that provides a personalized diet, recommendations, and care plans. Vivante Health, Inc. was incorporated in 2015 and is based in Houston, Texas with an additional office in Athens, Greece.

Ada is a global health company founded by doctors, scientists, and industry pioneers to create new possibilities for personal health. Ada’s core system connects medical knowledge with intelligent technology to help all people actively manage their health and medical professionals to deliver effective care. Ada is proud to collaborate with leading health systems and global non-profit organizations to carry out this vision. The #1 medical app for 130 countries, almost 20 million assessments have been completed since its global launch in 2016.

Founded by Stuart Schreiber, Benjamin Cravatt, Stephanie Dougan, and Vasanthi Viswanathan, Kojin is accelerating a drug discovery platform that connects complex cell states to known biochemical processes such as ferroptosis, or iron-dependent cell death, and enables the development of selective therapies for a broad range of hard-to-treat diseases. The company’s investors include Polaris Partners, Newpath Partners, Cathay Health, Leaps by Bayer, AbbVie Inc., Eventide Asset Management, Alexandria, and the Dana-Farber Cancer Institute venture firm, Binney Street Capital.

Egenesis Inc., a biotechnology company, operates as a gene editing and genome engineering that develops human transplantable organs, tissues, and cells. It offers a gene editing platform for developing human compatible organs. The company also provides development, such as gene engineering, single cell cloning, somatic cell nuclear/embryo transfer, organ procurement, and transplantation. The company was incorporated in 2015 and is based in Cambridge, Massachusetts with an additional office in New York, New York.

Recursion Pharmaceuticals is a biotechnology company based in Salt Lake City. Recursion combines experimental biology, automation, and artificial intelligence in a massively parallel system to quickly and efficiently identify treatments for any disease which can be modeled at the cellular level. From its initial and continued focus on drug repurposing to treat rare diseases, Recursion has broadened its platform to probe rich data from high-throughput automated screens for a number of indications, including aging, inflammation, infectious disease, and immunology. Recursion is aggressively leveraging technology to build a robust and reliable map of human cellular biology, which will enable a radical shift in the pace and scale at which new treatments will benefit patients.

Pyxis Oncology is a developer of antibody therapeutics intended to promote the body's immune response to cancer. The company has engaged in deep analyses of tumor antigen-specific tumor-infiltrating lymphocytes (TILs) within hot tumors and of tumor cell signaling pathways within cold tumors, providing laboratories with development of novel antibody-based immunotherapies. It was founded in 2019 and is based in Boston, Massachusetts.

Amfora is an emerging leader in the use of biotechnology to address the rapidly growing global demand for protein. Amfora is working to develop nutritionally enhanced forage crops for a market expected to have an annual value of as much as $12 billion a year. The company is based in San Francisco, California and is a portfolio company of Spruce Capital Partners LLC/MLS II Fund.

CoverCress is a biotechnology company that focuses on research and development of renewable fuel and livestock feed. It specializes in producing an oilseed crop for food, bioenergy, and cattle feed. It specializes in the fields of agriculture, biotechnology, plants, genetics, cover crop, and precision agriculture. CoverCress was founded in 2013 by Jerry Steiner and Dr. Tim Ulmasov and is headquartered in St. Louis Missouri.

Unfold focuses on innovating vegetable varieties that deliver optimized quality and sensory experience in the vertical farming industry. They combine leading seed genetics with the agronomic expertise to dramatically advance productivity, flavor, and other consumer preferences. It was founded in 2020 and is headquartered in Sacramento, California.

Azitra is a clinical-stage medical dermatology company that leverages extensive scientific knowledge about the skin microbiome to discover and develop novel products for the treatment of adverse skin conditions and diseases.The Company’s technology platform, developed in collaboration with scientists at Yale University and the Jackson Laboratory, is based on a proprietary strain of the natural commensal bacteria Staphylococcus epidermidis.

Apollo helps farmers in emerging markets maximize their profits. We use agronomic machine learning, remote sensing, and mobile phones to deliver a customized package of credit, high-quality farm inputs, and advice that can double farm yields, starting in Kenya. Apollo assesses farmer credit risk and customizes each package to a farmer's specific location using satellite data, soil data, farmer behavior data and crop yield models. Our team team brings together tech and operations experience from The Climate Corporation (acquired for ~$1B), Tesla, and One Acre Fund.

Triumvira Immunologics, Inc. (“Triumvira”) is an immunotherapy company co-founded in 2015 by Dr. Jonathan Bramson at McMaster University and Bloom Burton & Co., with the vision of developing novel T cell therapies that are safer and more efficacious than current cancer treatments, including chimeric antigen receptor (CAR) and engineered T cell receptor (TCR) therapies. Their proprietary T cell Antigen Coupler (TAC) technology recruits the entire natural T cell receptor and is independent of the major histocompatibility complex (MHC), allowing for the development of better therapies for a broader range of patients with solid or liquid malignancies and also with diseases other than cancer.

Pairwise is a purpose-driven food+tech company dedicated to building a healthier world through better fruits and vegetables. Founded in 2017 by Drs. David Liu, Feng Zhang, J. Keith Joung, Tom Adams, and Haven Baker, Pairwise holds licenses from Harvard and Massachusetts General Hospital to base editing and high-fidelity enzymes, and has an expanding internal portfolio of tools and traits. The Pairwise team is growing new types of fruits and vegetables, including leafy greens, berries, and stonefruit, with the first products expected within a few years. The Pairwise team is comprised of leaders in agriculture, CPG food, and research and development.

Dewpoint Therapeutics, Inc., a biotech company, engages in research of biomolecular condensates and cellular function to develop treatments for diseases like cancer, neurodegenerative disorders, immunology, cardiovascular, women’s health, and virology. The company was incorporated in 2018 and is based in Boston, Massachusetts.

Century Therapeutics, Inc. engages in the development of induced pluripotent stem cell- (iPSC) based drugs for the treatment of hematologic and solid malignancies. The use of iPSC enables multiple rounds of cellular engineering to produce master cell banks of modified cells that can be expanded and differentiated into immune effector cells to supply allogeneic, homogeneous therapeutic products. The company was founded in 2018 and is based in Philadelphia, Pennsylvania.

Pyxis Oncology is a developer of antibody therapeutics intended to promote the body's immune response to cancer. The company has engaged in deep analyses of tumor antigen-specific tumor-infiltrating lymphocytes (TILs) within hot tumors and of tumor cell signaling pathways within cold tumors, providing laboratories with development of novel antibody-based immunotherapies. It was founded in 2019 and is based in Boston, Massachusetts.

Dewpoint Therapeutics, Inc., a biotech company, engages in research of biomolecular condensates and cellular function to develop treatments for diseases like cancer, neurodegenerative disorders, immunology, cardiovascular, women’s health, and virology. The company was incorporated in 2018 and is based in Boston, Massachusetts.

Grão Direto LTDA develops a digital trading platform for buying and selling grains, which allows farmers and grain buyers to negotiate and close deals. The company's platform improves market intelligence analysis for growers and buyers by helping them to make better decisions and also supports other processes associated with grain trading, such as logistics, contract management, and financial products. It provides a web platform and application for smartphones. The company was founded in 2016 and is based in Uberaba, Brazil.

Rantizo delivers targeted liquid dry applications for agriculture precisely where and when they are needed in the field.The company's system utilizes an electrostatic spraying technology which reduces problems with uneven coverage and covers crops uniformly, enabling farmers to apply pesticides and chemicals in the farms evenly without a hassle and within a short duration of time.

Vesigen, Inc. develops therapeutic products directed to intracellular targets using extracellular vesicle delivery technology. The company designs, discovers, and develops medicines that target intracellular delivery, cell membranes, and degradative systems barriers. Its ARMMs technology enables translation of new modalities, such as RNAs and gene-editing complexes into novel treatments for multiple diseases. Vesigen, Inc. was incorporated in 2020 and is based in Cambridge, Massachusetts.