Cultivation Capital is a St. Louis, Missouri-based venture capital firm that backs seed- to Series B–stage companies in the United States. Its focus includes life sciences, healthcare, agriculture technology, and related software, information technology, and geospatial sectors, with investments spanning early rounds to support product development and market entry.

Missouri Technology is a venture capital firm based in Jefferson City, Missouri, investing in Missouri-based high-tech companies across life sciences, animal health, applied engineering, biomedical science, defense and homeland security, plant science, and technology, with a focus on promoting entrepreneurship and the growth of high-tech companies in the state.

BioGenerator is the non-profit venture development organization of BioSTL, based in St. Louis, Missouri, that supports the creation and growth of bioscience startups in the St. Louis region. It provides early-stage companies with pre-seed and seed funding, shared laboratory space with specialized equipment, and in-depth management support to help turn scientific ideas into sustainable businesses. As BioSTL’s venture arm, BioGenerator often leads or co-leads investments in early-stage ventures and coordinates with local angel groups and other capital to enable follow-on funding. Its focus spans bioscience sectors such as healthcare, plant sciences, medical devices and diagnostics, information technology for life sciences, and related research tools, with the aim of accelerating translation of research and contributing to regional economic growth.

St. Louis Arch Angels is a network of accredited investors based in St. Louis, Missouri, focused on seed, startup and early-stage capital in the Saint Louis region. The group funds and supports high-potential ventures drawn from the local startup ecosystem, including universities, research institutes, companies and technology incubators, to advance regional innovation. Investments are typically made through member contributions, with individual investments between $25,000 and $100,000 and group investments from $250,000 to $750,000, with an investment horizon of up to eight years. The Arch Angels complement the region's financing options along the seed to later-stage continuum and address funding gaps underserved by institutional venture firms.

Serra Ventures is a venture capital firm based in Champaign, Illinois. Founded in 2008, it invests in technology companies at early and growth stages across the United States, with select international activity, focusing on information technology, deep technology, instrumentation, devices, B2B software as a service, and agricultural technologies.

KCRise Fund is a Kansas City, Missouri-based venture capital firm focused on early-stage investments in Kansas and western Missouri. Founded in 2016 as part of the KCRising initiative to build regional capacity and scale local businesses, it backs software, information technology, and business-to-business sectors, including SaaS, supply chain/logistics, digital health, GovTech, and HRTech, as well as energy, financial services, and healthcare. The firm typically participates in seed and early-stage rounds and co-invests with other institutional investors, with multiple vintages launched to support the region's growth.

Lewis & Clark Ventures is a Saint Louis, Missouri-based private equity firm founded in 2014 that focuses on early-stage investments in healthcare and technology. It targets high-potential B2B software, fintech, and digital health companies and aims to be a trusted partner to entrepreneurs, providing support to help portfolio companies scale and achieve lasting impact.

The Yield Lab is a venture capital firm and accelerator focused on agtech and agrifood technology. Based in Saint Louis, Missouri, it operates a global network with regional activities in Latin America, Europe and Asia Pacific. The firm provides early-stage investments in agriculture technology startups and supports them through accelerator programs to advance product development, commercialization and scale across the food and farming value chain.

Prolog Ventures is a Missouri-headquartered venture capital firm that backs early-stage and growth-stage companies in life sciences, healthcare and consumer wellness. It targets sectors including pharmaceuticals and biotechnology, medical devices and diagnostics, nutrition and functional foods, personal care, home care and related consumer health technologies and business models. The firm typically invests in North America and looks for opportunities that advance health and well-being through proprietary ingredients, formulations and delivery technologies.

iSelect Fund is a venture capital firm based in St. Louis, Missouri, focused on early-stage and growth investments across agriculture, food tech, healthcare, software and life sciences. The firm backs seed through Series A and B rounds and targets opportunities in the United States, Canada, Europe and other markets, with a regional emphasis on the United States Midwest and Great Lakes. It prioritizes companies advancing plant sciences, seed genetics, sustainability, immunotherapy and personalized medicine, as well as business-to-business software, resource efficiency and related sectors. iSelect Fund seeks to build a portfolio through long-term, value-added partnerships, supporting companies from startup to scale-up as they develop innovative solutions in food, health and related industries. The firm operates across multiple markets.

SixThirty is a venture capital firm and accelerator headquartered in Saint Louis, Missouri, focusing on early-stage B2B fintech, insurtech, and cybersecurity startups. It operates a go-to-market program that provides funding, mentorship, and connections to help portfolio companies grow, typically supporting eight to twelve startups per year. The firm invests in a broad range of financial services technology areas, including wealth and asset management, payments, core processing, fraud and privacy, regulatory and compliance, and risk management, as well as insurance and cybersecurity across global markets. By combining capital with hands-on development support and partnerships with strategic corporate investors, SixThirty seeks to accelerate global growth for its portfolio companies.

Established in 2018, Lightchain Capital is a venture capital firm headquartered in Saint Louis, Missouri. It specializes in investing in early-stage companies within the life sciences sector, with a focus on improving outcomes for cancer patients.

Ascend Venture Group is a New York-based venture capital firm founded in 2000 that targets early-stage technology companies across North America. It partners with entrepreneurs to provide financial and strategic support to accelerate growth in software and related tech sectors.

Arsenal Capital Management is a venture capital investment firm founded in 2012 and based in Saint Louis, Missouri. It focuses on investing in growth companies.

Dundee Venture Capital is a venture capital firm founded in 2010 and based in Omaha, Nebraska, with additional offices in Chicago, Minneapolis and Boulder. It targets seed and post-seed technology investments across the United States, focusing on B2B software and SaaS, commerce and fintech, and supply chain technologies, including e-commerce infrastructure. Typical initial commitments range from about 0.25 to 0.75 million dollars, with potential follow-on investments to support growth. The firm often takes board seats or observers in lead rounds to help portfolio companies scale, emphasizing technology-enabled businesses in underserved U.S. markets. Dundee avoids sectors requiring government approval and seeks opportunities across a broad range of software, e-commerce, and related services that can reach nationwide audiences.

RiverVest Venture Partners is a venture capital firm headquartered in Saint Louis, Missouri, with offices in Cleveland and San Diego. It focuses on identifying and supporting early-stage life science companies in the United States, particularly in biopharma and medical devices. The firm provides strategic guidance to entrepreneurs and pursues select later-stage opportunities to diversify risk, aiming to build shareholder value. It targets healthcare devices and supplies, pharmaceuticals, biotechnology, life sciences, oncology, and related sectors.

Fulcrum Global Capital, founded in 2016, is a venture capital firm based in Kansas City, Missouri, that invests in companies operating in agriculture, agtech, food production and safety, food waste, and animal health.

Firebrand Ventures is an early-stage venture capital firm based in Kansas City, Missouri, founded in 2016 with offices in Austin, Texas, and Boulder, Colorado. It invests in software and technology startups across the United States and Canada, prioritizing ventures in underserved markets. The firm supports early-stage companies with capital and guidance, aiming to enable growth while reserving capital for select follow-on investments.

Synchrony Bio is a venture capital investment firm based in Saint Louis, Missouri, founded in 2018. It concentrates on early-stage biomedical, medical device, and life science ventures, engaging in early-stage investing and venture development. Through these activities, the firm seeks to mitigate risk and accelerate value and development timelines for portfolio companies.

Mid-America Angels is a regional network of accredited investors that identifies and funds early-stage companies. It participates in seed, Series A, and Series B rounds depending on the capital raise and provides a framework to pool the members’ knowledge, experience, and investment capital. Founded in 2006, the organization is based in Kansas and Oklahoma and focuses on the Kansas-Missouri region around Kansas City, typically investing between $250,000 and $1,500,000 per opportunity.

Kingdom Capital is an investment firm engaged in venture capital and private equity activities. Founded in 2016 and based in Chesterfield, Missouri, it targets early- and growth-stage opportunities in healthcare, medical, and technology sectors, including artificial intelligence, data science, therapeutics, medical devices, diagnostics, healthcare IT, and life science tools. The firm operates a platform that connects values-driven investors with its portfolio opportunities and philanthropic partners, supporting initiatives through its Kingdom Capital Foundation. Through this integrated approach, Kingdom Capital aims to advance innovation at the intersection of healthcare and technology while building sustainable value for its stakeholders.

Royal Street Ventures is a venture capital and private equity firm based in Park City, Utah, with an additional office in Kansas City, Missouri. The firm focuses on early-stage technology companies and seeks opportunities in undercapitalized markets across the Mountain West, Midwest, Pacific Northwest, and California. It also targets sectors such as health and wellness, transportation and logistics, fintech, education, consumer products, and specialized manufacturing. Royal Street Ventures typically invests in seed and early-stage rounds and may participate in growth capital, often engaging with portfolio companies through board roles to provide strategic guidance and governance.

American Outdoor Brands is a manufacturer of outdoor and firearms products serving hunting, fishing, camping, shooting, personal security and defense markets. The company designs and produces a broad range of gear, including shooting supplies, rests and vaults; premium knives and tools for fishing and hunting; land management tools for hunting preparedness; harvesting and post-hunt products; electro-optical devices such as hunting optics, firearm aiming devices, flashlights and laser grips; reloading, gunsmithing and firearm cleaning supplies; and survival, camping and emergency preparedness products. It sells through e-commerce and traditional distribution channels under the Marksman, Defender, Harvester and Adventure brands. The business is headquartered in Columbia, Missouri.

OCA Ventures is a Chicago-based venture capital firm founded in 1999 that makes early-stage equity investments in technology-driven companies in the United States and Canada. The firm concentrates on software and information technology-enabled businesses, including consumer software, enterprise software, fintech, and digital health, with a preference for companies demonstrating dramatic growth potential and scalable models. By backing startups at seed to early-growth stages, OCA Ventures aims to support firms developing innovative software solutions and technology-enabled services across industries, including healthcare technology systems and financial services. The team seeks partnerships with entrepreneurs building scalable platforms and differentiated products, leveraging its regional presence and sector focus to add operational and strategic value.

M25 is a Chicago-based venture capital firm focused on the Midwest. Founded in 2015, it backs pre-seed and seed-stage technology companies headquartered in the Midwest and Great Lakes region, and has invested in more than 90 startups across numerous cities and states. Led by Victor Gutwein and Mike Asem, M25 employs an analytical, collaborative approach to portfolio-building across software, information technology and other tech-enabled sectors. The firm aims to support the regional startup ecosystem by providing early-stage capital and guidance to founders as they scale their businesses.

Countdown Capital is a Columbia, Missouri-based venture capital firm founded in 2020 that concentrates on early-stage investments in industrial companies, with a focus on aerospace, manufacturing, defense, energy, and construction sectors.

Stadia Ventures is a venture capital firm and sports business accelerator based in Saint Louis, Missouri, with expanded operations to Frisco/Dallas. It focuses on sports and esports, and adjacent sectors such as lifestyle and recreation, performance and wellness, fan engagement and experience, content, media and entertainment, and sports betting. The organization runs a semi-annual accelerator that selects 4–6 startups, typically invests around $100K in each, and provides a 14-week bootcamp with mentorship and business development support to help founders access customers within its network. Since its founding in 2015, Stadia Ventures has built a portfolio of about 40 sports and esports companies, led multiple exits, and helped portfolio firms raise over $53 million.

FINTOP Capital is a venture capital firm based in Nashville, Tennessee, founded in 2016. It targets B2B software-as-a-service companies in the fintech space that have a proven product, real revenues, and leadership with industry experience. The firm maintains additional offices in Hoboken, New Jersey, and St. Louis, Missouri.

Established in 2018, Cure8 Ventures is an early-stage investment firm headquartered in Saint Louis, Missouri. It specializes in investing within the food, healthcare, and wellness sectors.

Armstrong Teasdale is a law firm established in 1901 and headquartered in Saint Louis, Missouri. It provides a broad range of legal services, including litigation and dispute resolution, intellectual property, environmental law, corporate services, mergers and acquisitions, bankruptcy, private equity and venture capital, and marijuana and hemp law. The firm serves clients across sectors such as aerospace and defense, technology, life sciences, healthcare, real estate, media, and financial services, delivering client-focused service and strong results in both the boardroom and the courtroom.

Iyengar Capital Partners is a venture capital investment firm based in Clayton, Missouri, founded in 2022. It focuses on healthcare and life sciences, including medical devices and healthcare services, and seeks to partner with entrepreneurs who are transforming healthcare through clinical innovation.

Nidus Partners is a venture capital firm based in Saint Louis, Missouri, focused on seed and early-stage investments in technology and energy. It targets the energy sector, including renewables, energy efficiency, energy conversion, storage, biomass conversion, bioconversion, and carbon capture technologies, and backs innovations such as biofuels, gasification, bioelectrochemical conversion, predictive modeling, and renewable biochemicals.

Lagomaj Capital is a venture capital firm founded in 2017 and based in Saint Louis, Missouri. It invests across information technology, digital health, life sciences, and big data, spanning seed, early-stage, and later-stage rounds. The firm supports portfolio entrepreneurs with fundraising guidance, networking opportunities, and strategic consulting to turn ideas into scalable ventures.

Service Provider Capital is a Colorado-based venture capital firm founded in 2014 that funds seed-stage technology companies across domains such as artificial intelligence, machine learning, blockchain, cybersecurity, fintech, e-commerce, education technology, hardware, robotics, information technology, health tech, and cannabis. The firm also co-invests in Series A rounds led by institutional venture funds, providing capital and guidance to startups in the United States, including the Midwest and Southeast regions.

Leaps by Bayer is the corporate venture capital unit of Bayer, focused on funding paradigm-shifting advances in the life sciences. Based in Leverkusen, Germany, and founded in 2015, it concentrates on biotechnology, agriculture, and healthcare, making significant and sustained investments in disruptive biotechnologies with the potential to have the greatest impact on humanity.

Jump Capital is a venture capital firm based in Chicago and New York that makes seed and Series A investments in data-driven technology companies. It focuses on FinTech, B2B SaaS, IT and data infrastructure, and media, and backs opportunities across sectors including B2B, B2C, financial services, healthcare, information technology, AI and big data, cybersecurity, cloud, e-commerce, IoT, and education technology in the United States. The firm provides hands-on support through an operating platform and institutional resources to help entrepreneurs, partnering with management teams that benefit from real-world operating experience. Typical initial investment checks are between $2 million and $10 million.

Right Side Capital Management is a San Francisco-based venture capital firm founded in 2010 that invests in early-stage technology startups. It specializes in pre-seed and seed rounds for capital-efficient companies, with a focus on the United States and Canada and occasional activity in Western Europe, Israel, Australia, and New Zealand. The firm typically makes 75 to 100 investments per year, with round sizes from 50,000 to 500,000 and pre-money valuations ranging from 1,000,000 to 3,500,000. Portfolio companies are typically located outside the San Francisco Bay Area and New York City, and the firm aims to provide a clear yes or no on opportunities within about two weeks.

Prospect Capital Corporation is a publicly traded business development company that provides flexible debt and equity capital to middle-market companies in the United States and Canada. It emphasizes sponsor-backed and direct-lending transactions, offering private debt and private equity solutions to both sponsor-owned and independent middle-market businesses across multiple industries. The company participates in growth financings, acquisitions, recapitalizations, and other structured financings, often through various debt instruments and equity investments, and seeks to support clients with tailored capital solutions. By deploying capital across diverse sectors, Prospect Capital aims to generate steady returns for investors while focusing on the middle market.

Samsung Electronics is a global technology company based in South Korea that designs, manufactures, and sells a wide range of electronics and device solutions. Its portfolio spans consumer electronics (mobile devices, televisions, home appliances, cameras), information technology products (PCs, peripherals, printers), semiconductors, memory and storage, and display technologies. The company also provides telecommunications infrastructure and related services, and conducts extensive research and development to advance core technologies. With a global footprint across Korea, China, the Americas, Europe, and the Asia Pacific, Samsung Electronics is a leading supplier of smartphones, memory chips, and displays, and it coordinates significant manufacturing and supply chain activities to support its varied product lines.

Morningside is a Boston-based investment firm founded in 1986 as a family office for the Chan family. It makes venture capital investments in companies with novel science and technology, with deep expertise in life sciences, digital health, artificial intelligence, materials, and technology. The firm takes a long-term approach to building companies and emphasizes ethical conduct. In addition to its investment activities, Morningside supports charitable initiatives in education, research and healthcare, including collaborations with Harvard T.H. Chan School of Public Health, UMass Chan Medical School, and the MIT Morningside Academy for Design.

Based in San Mateo, California, Sierra Ventures is a Bay Area early-stage venture firm with over three decades of experience and more than $2 billion in assets under management. The firm invests globally, focusing on Seed and Series A rounds in Next Generation Enterprise and Emerging Technologies, and it typically leads investments while reserving capital for follow-on rounds. Its sectors include artificial intelligence and machine learning, big data, cloud, fintech, health tech, IoT, infrastructure, marketplaces, SaaS, and security, as well as emerging technologies such as 5G, devices, blockchain, robotics, and virtual/augmented reality. Initial bets are commonly between $500,000 and $7 million, with total investments per company ranging up to $15 million. Sierra Ventures often takes a board seat when leading a round. Although it maintains a global outlook, the firm concentrates on North America and pursues opportunities abroad in Israel and China. The firm supports portfolio companies with its network of entrepreneurs, operators, and experts to help accelerate growth.

S2G Investments is a multi-stage investment firm that targets venture and growth-stage companies in food and agriculture, oceans, and energy sectors. It provides capital to businesses shaping the future of food systems and energy resources and supports entrepreneurs and leadership teams with market-driven solutions intended to deliver greater value, improved results, and superior performance relative to conventional options.

TIA Ventures is a seed-stage venture capital firm based in New York that invests in B2B software, SaaS, platforms, and related small business marketplaces. It partners with early-stage companies to help them scale and achieve product-market fit by applying expert customer and team diligence to identify viable growth paths during the Critical Period. Through close collaboration with founders, the firm supports early growth initiatives designed to accelerate scale and adoption, with a focus on building durable B2B software businesses.

HPS Investment Partners is a global investment firm focused on non-investment grade credit across the capital structure. Founded in 2007 and headquartered in New York, it operates a worldwide network of offices. The firm originated as a unit of Highbridge Capital Management, a subsidiary of J.P. Morgan Asset Management, and was acquired by its principals in 2016 after Highbridge’s hedge fund strategies remained with J.P. Morgan. HPS manages a variety of strategies, including syndicated leveraged loans, high-yield bonds, privately negotiated senior secured debt, mezzanine, asset-based lending, and private equity, and serves clients across industries such as insurance, healthcare, media, retail, logistics, and marine.

Hard Yaka is an investment firm based in Crystal Bay, Nevada. It engages in private equity and venture investments, focusing on technology and financial services sectors, including early-stage investments in exchange-related startups and opportunities in buyouts and distressed assets, often pursuing majority stakes.

Tech Council Ventures is a New Jersey-based venture capital firm founded in 2000 and headquartered in Summit, New Jersey. It focuses on early-stage investments, including seed and Series A rounds, across the United States, in technology, biotech and life sciences, enterprise software, media, telecom, cleantech, edtech, and healthcare sectors. The firm partners with entrepreneurs to build leading businesses and drive returns for investors while supporting growth through the early development stages.

Uncorrelated Ventures is a venture capital firm founded in 2019 by Salil Deshpande and headquartered in San Francisco, California. It backs early-stage companies focused on infrastructure software and seeks opportunities in related areas such as decentralized finance, cryptocurrency, blockchain, and fintech.

Stout Street Capital is a Denver, Colorado-based venture capital firm that backs early-stage technology companies. It concentrates on software and B2B SaaS, while also investing in fintech, advanced materials, robotics, and artificial intelligence. The firm targets opportunities in under-served markets in the central United States, with a particular emphasis on the Rocky Mountain region. Its approach combines data-driven analysis, market assessment, and thorough due diligence to select ventures that can improve efficiency and generate measurable value as they scale.

Capital Midwest Fund is a venture capital firm based in Mequon, Wisconsin, that backs early-stage companies in the Midwest across sectors such as advanced manufacturing, life sciences, healthcare, B2B and business services, software and SaaS, information technology and IoT, and energy. The firm concentrates on Midwest investments, with Wisconsin as a primary focus, and targets initial investments typically in the low to mid single-digit millions per company. It also pursues ESG and diversity-inclusion related investments as part of its strategy.

Stephens is a privately held investment banking and financial services firm founded in 1933 and based in Little Rock, Arkansas. It provides services across investment banking, insurance, capital management, institutional equities, research, private equity, fixed income, sales and trading, public finance, and wealth management, serving clients in sectors such as aerospace, consumer, energy, industrials, financial services, healthcare, life sciences, power, technology, telecommunications, and media.