Lightchain Capital

Established in 2018, Lightchain Capital is a venture capital firm headquartered in Saint Louis, Missouri. It specializes in investing in early-stage companies within the life sciences sector, with a focus on improving outcomes for cancer patients.

Drew Dennison

Managing Director

5 past transactions

Geneoscopy

Series C in 2025
Geneoscopy develops non-invasive diagnostics using stool-derived eukaryotic RNA to prevent, detect, and guide treatment for gastrointestinal diseases. Its platform technology enables early-stage detection of colorectal cancer neoplasms and improves screening compliance.

SimpleRose

Venture Round in 2023
SimpleRose Inc. is a technology company based in Saint Louis, Missouri, that specializes in developing a prescriptive analytics platform aimed at enhancing decision-making in complex environments. Founded in 2018, the company offers solutions that optimize and accelerate processes such as scheduling, production planning, and portfolio optimization. By leveraging advanced algorithmic innovations, SimpleRose’s platform provides high levels of numerical accuracy, speed, and the capability for continuous analysis, enabling organizations to effectively address operational challenges and make informed decisions.

AI Proteins

Seed Round in 2022
AI Proteins is a biotechnology company established in 2021, headquartered in Boston, Massachusetts. It specializes in designing and engineering synthetic mini protein therapeutics using artificial intelligence-based platforms.

NextRNA Therapeutics

Series A in 2022
NextRNA Therapeutics is a biotechnology company based in Cambridge, Massachusetts, founded in 2020. The company focuses on developing targeted therapeutics by discovering novel non-coding ribonucleic acids (ncRNAs) linked to various diseases. Utilizing an innovative discovery platform, NextRNA identifies and modulates RNA-binding proteins associated with disease functions of ncRNAs. This approach aims to disrupt the interactions between disease-related ncRNAs and their protein partners, thereby enabling medical practitioners to address and potentially cure a range of diseases.

SimpleRose

Venture Round in 2018
SimpleRose Inc. is a technology company based in Saint Louis, Missouri, that specializes in developing a prescriptive analytics platform aimed at enhancing decision-making in complex environments. Founded in 2018, the company offers solutions that optimize and accelerate processes such as scheduling, production planning, and portfolio optimization. By leveraging advanced algorithmic innovations, SimpleRose’s platform provides high levels of numerical accuracy, speed, and the capability for continuous analysis, enabling organizations to effectively address operational challenges and make informed decisions.
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