St. Louis Arch Angels

Maximum Fidelity Surgical Simulations designs and produces medical, surgical, ophthalmic, and veterinary instruments and apparatus. The company specializes in hyper‑realistic medical education by creating a human‑like mechanical cadaver system that incorporates real human tissue and a perfusion system using Simblood and a pulsatile pump to replicate circulatory and cardiac functions. This technology allows trainees to experience operating room and trauma care scenarios without using a human body, thereby enhancing skill acquisition while eliminating risk to patients. Additionally, the firm supplies equipment for testing biomedical devices and prepares medical personnel for military trauma situations.

Peptyde Bio is an Agtech startup focused on combating fungal diseases through innovative bio-fungicidal technology. The company specializes in developing natural antimicrobial peptides (AMPs) sourced from plants, which offer a cost-effective and efficient alternative for treating such diseases. By leveraging these natural compounds, Peptyde Bio aims to establish itself as a leading supplier of AMPs, providing effective solutions for agricultural challenges while promoting sustainable practices in crop protection.

SentiAR, Inc. is a digital health company based in St. Louis, Missouri, focused on developing a 3D augmented reality holographic platform aimed at enhancing interventional medical procedures. Incorporated in 2017 and originating from Washington University, SentiAR's technology allows for real-time holographic visualization of a patient's anatomy and catheter positioning during procedures, utilizing data from various imaging modalities such as CT and MRI. This innovative platform is designed to create an interactive and controllable interface for clinicians, thereby improving the accuracy and safety of cardiac arrhythmia treatments. SentiAR's mission is to significantly enhance the experience for both patients and healthcare providers in catheter lab environments. The company is currently working towards obtaining FDA approval for its platform.

Impetus AG is engaged in the development of innovative insect control solutions that prioritize safety, effectiveness, and sustainability. The company specializes in creating bi-specific plant-based proteins designed to protect crops from harmful insects. Utilizing Bacillus thuringiensis technology, Impetus AG's products enhance crop yield by integrating antibodies within plant structures. This approach addresses the challenge of insect resistance that has emerged with existing commercial insect control products, offering farmers durable alternatives that support sustainable agriculture.

Sequoia Sciences, Inc. is a pharmaceutical company based in Saint Louis, Missouri, founded in 1999. The company focuses on discovering and developing innovative treatments for bacterial infections and cancers, specifically targeting unmet medical needs such as lung infections in cystic fibrosis patients and recurrent urinary tract infections. Sequoia's development programs include small molecules and vaccines aimed at combating these conditions. The company aims to enhance the quality of life for individuals affected by chronic bacterial infections and cancers. In addition to its internal research and development efforts, Sequoia collaborates with laboratories, universities, clinical research sites, and private businesses to advance its projects. Their expertise in microscale structure determination is applied to elucidate the structures of natural products and their biosynthetic intermediates for both academic and industrial partners.

Amplified Sciences LLC is a molecular diagnostics company based in West Lafayette, Indiana, that specializes in the early detection of debilitating diseases, including pancreatic cancer and kidney disease. The company utilizes an ultra-sensitive molecular sensing technology, licensed exclusively from Purdue University, which allows for the detection of disease markers at the single-molecule level. This technology is versatile and disease state agnostic, enabling accurate diagnosis using bodily fluids such as urine and saliva. Amplified Sciences has developed a point-of-care system that combines sensing and assay methods with low-cost biospecimen collection devices, facilitating scalability and accessibility in healthcare settings. Their first application focuses on the early detection of pancreatic cancer, addressing a significant unmet medical need and offering a favorable reimbursement pathway. With a working prototype and published proof of concept data, Amplified Sciences aims to provide healthcare professionals with innovative diagnostics that can operate with a single sample on one instrument.

CoverCress Inc. is a biotechnology company based in Saint Louis, Missouri, founded in 2013. The company focuses on developing and commercializing field pennycress as an oilseed crop, which is utilized for producing oil for renewable fuels and meal for livestock feed. By genetically improving pennycress, CoverCress aims to create a sustainable cover crop that enhances soil health and offers benefits for farmers during corn and soybean planting seasons. The company’s efforts are centered on sustainable agricultural practices, allowing farmers to maximize yields while minimizing input and carbon emissions. Formerly known as Arvegenix Inc., CoverCress reflects a commitment to innovation in agriculture, biotechnology, and renewable energy solutions.

FinLocker, LLC is a financial technology company based in St. Louis, Missouri, founded in 2014. It specializes in developing a consumer-enabled financial data platform that enhances the loan process for mortgages and various financial products. FinLocker provides a personal financial assistant tool that captures essential borrower data with consumer consent, utilizing intelligent analytics to offer tailored loan product recommendations based on individual financial profiles. Its solutions aim to streamline lending processes by improving data collection, verification, and analytics, thereby reducing costs, time, and risks for lenders. Additionally, FinLocker enhances the borrower experience by enabling consumers to manage their finances more effectively, apply for loans with reduced documentation hassles, and control data sharing.

Ryvit develops an integration software that delivers seamless flow of data between premise and software used in the construction industry. The software integrates software application to enterprise resource product, customer relationship management, e-commerce, social apps, and specialty industry-specific system without exhausting development resources, empowering companies to experience the ease of intelligent integrations, driving profit through automation and optimization of the applications in use. Ryvit is headquartered in Saint Louis, Missouri.

IDEATE Medical develops sterilization technology for the safe and rapid terminal sterilization of all endoscopic devices. The mission of IDEATE Medical is to lower the infection risk from the 75 million endoscope procedures conducted in the U.S. each year. IDEATE Medical understands the importance of efficacy, compatibility, and throughput and has developed a unique, innovative, low-temperature sterilization technology for the safe and rapid terminal sterilization of all endoscopic devices for every procedure. Our technology utilizes the benefits of Vapor Hydrogen Peroxide (VHP) sterilization technology but incorporates key innovations to address the specific challenges associated with the terminal sterilization of long multi-channel endoscopic medical devices. With its innovations, the most challenging endoscopic devices can be terminally sterilized in 30 minutes with no impact on the endoscopic device.

Balance the Superfood Shot is a health supplement company based in Kansas City that specializes in nutritional products aimed at promoting daily intake of fruits and vegetables. Founded in 2011, the company offers premium health and nutrition solutions that emphasize preventative health through bio-available and whole food blends. Its flagship product line includes shelf-stable tonics that provide consumers with half a day's serving of organic fruits and vegetables, along with essential multivitamins and nutrients. By focusing on convenience and nutritional quality, Balance the Superfood Shot enables individuals to maintain a healthy and balanced lifestyle.

ProteoSense LLC, founded in 2013 and based in Columbus, Ohio, specializes in developing a platform to detect food-borne pathogens such as E-coli, salmonella, listeria, and campylobacter. The company's flagship product is RapidScan, a handheld testing system designed for time-critical and remote applications. This system allows users to test for key food-borne pathogens quickly and efficiently, making it valuable for growers, packers, processors, shippers, and wholesalers in the food industry across the United States.

Rozzy Learning Company mission is to bring hands-on STEAM (Science, Technology, Engineering, Art, Math) programs and resources to young learners and teachers to promote curiosity, critical thinking skills, and exploration. They focus on STEAM careers because they are the fastest growing, highest paying jobs in the world. By introducing kids to STEAM early on, you are setting them up for success in and outside of school. Unlike other STEAM companies, they have affordable programs that don‘t require expensive technology or materials. Bonus? Their programs fit into teachers’ busy schedules!

Viosera Therapeutics, Inc. is a biopharmaceutical company focused on developing innovative therapies to combat antibiotic resistance, particularly targeting methicillin-resistant Staphylococcus aureus (MRSA). Founded in July 2016, the company is headquartered in Sunnyvale, California, with additional operations in St. Louis, Missouri. Viosera's flagship product, VT1, is designed to treat MRSA bloodstream infections. The company employs artificial intelligence to identify and develop drug combinations that predict and block resistance evolution in both bacterial infections and cancer treatment. Through these advancements, Viosera aims to provide effective solutions that address the growing threat of antibiotic resistance, ultimately improving patient outcomes.

CheckTheQ, Inc. is a company based in Saint Louis, Missouri, founded in 2016, that offers a subscription service for tracking and communicating wait times in real-time. Primarily catering to airports, stadiums, and various venues, CheckTheQ provides a comprehensive airport management platform designed to enhance operational efficiency and reduce wait times. The platform utilizes advanced counting and customer response technologies to deliver integrated restroom monitoring solutions, enabling facilities to receive real-time feedback, send notifications, and track restroom usage. By offering data-driven insights, CheckTheQ helps both small, regional, and international airports optimize their operations, improve the traveler experience, and ultimately enhance customer satisfaction and staffing efficiency.

KaloCyte Inc., established in 2016 and based in Baltimore, Maryland, is a pre-clinical stage healthcare biotechnology company focused on developing innovative solutions for life-threatening blood loss scenarios. The company's flagship product, ErythroMer, is an artificial red blood cell substitute designed to be dried and bio-inspired, intended for use when stored red blood cells are unavailable or undesirable. This product aims to address critical gaps in trauma care services by providing a demonstrated proof of concept for treating hemorrhage situations effectively.

Lean Media, Inc. is a digital advertising company specializing in cookieless audience targeting services tailored for agribusiness and rural community advertisers. Founded in 2014 and based in Chesterfield, Missouri, the company employs advanced geo-targeting technology to connect with consumers at an individual level by analyzing IP addresses in conjunction with consumer databases. Lean Media's platform enables advertisers to customize campaigns based on specific workplaces, demographics, psychographics, and behavioral insights, allowing for more effective engagement and reduced advertising waste. The company focuses on delivering confidence to advertisers by enhancing their ability to reach target consumers through programmatic online display advertising.

Transactly is a real estate technology platform founded in 2018 and based in St. Charles, Missouri. It focuses on organizing and coordinating the closing process of real estate transactions across the United States. As the first tech-enabled transaction coordinator service, Transactly provides customers with a dedicated coordinator backed by a comprehensive support team. The platform aims to streamline real estate transactions for home buyers and sellers, enhancing transparency and efficiency. By managing the various tasks involved in the transaction process, Transactly enables real estate professionals, such as brokers and agents, to improve their service offerings and increase their revenue potential.

SwipeSum operates a payment processing management platform that helps businesses optimize merchant services and reduce costs by auditing merchant statements with proprietary software and advising on payment strategies. Its technology simplifies payment infrastructure, supports integrated payments and partnerships with software vendors and financial institutions, and aims to convert payments into a revenue-driving function. The company also offers an AI-powered statement analysis tool used to create quick cost comparisons and proposals for clients and partner organizations.

Aptimmune is a biotechnology company headquartered in St. Louis, Missouri, established in 2010. It specializes in the development of mucosal vaccines aimed at preventing viral diseases in swine, specifically targeting the Porcine Reproductive and Respiratory Syndrome virus (PRRSV) and influenza A virus. By employing innovative technologies, including a proprietary pig alveolar macrophage cell line known as ZMAC, Aptimmune creates effective nasal delivery vaccines that provide lasting immune responses and enhance disease protection for animal breeders.

CoverCress Inc. is a biotechnology company based in Saint Louis, Missouri, founded in 2013. The company focuses on developing and commercializing field pennycress as an oilseed crop, which is utilized for producing oil for renewable fuels and meal for livestock feed. By genetically improving pennycress, CoverCress aims to create a sustainable cover crop that enhances soil health and offers benefits for farmers during corn and soybean planting seasons. The company’s efforts are centered on sustainable agricultural practices, allowing farmers to maximize yields while minimizing input and carbon emissions. Formerly known as Arvegenix Inc., CoverCress reflects a commitment to innovation in agriculture, biotechnology, and renewable energy solutions.

Nexmatix is a developer and manufacturer focused on enhancing the efficiency of pneumatic systems through innovative products. Its primary offering is a line of smart directional control valves, which are designed to continuously monitor for leaks and improve operational performance. These valves are equipped with embedded sensors that provide real-time data on valve faults and pressure levels, allowing users to address issues proactively. By targeting one of the most inefficient components in pneumatic systems, Nexmatix aims to reduce energy consumption and lower operational costs, contributing to a reduced carbon footprint.

Cardiaform is a medical device company developing devices to diagnose and treat cardiovascular disease. Its devices will enable instantaneous high density, high definition electrical maps to support mapping unstable arrhythmias (ventricular tachycardia), reduce procedure time from 3-4 hours to less than 1 hour, and provide improved procedural success using only a single catheter.

Kogent Surgical, LLC specializes in the design, manufacture, and marketing of surgical and neurosurgical instruments. Founded in 2011 and based in Chesterfield, Missouri, the company offers a diverse range of products, including forceps, curettes, suture pushers, knives, and lighted suction tubes. Kogent Surgical is recognized as an industry leader in neurosurgical instruments, with a focus on providing high-quality products that enhance surgical precision and efficiency. The instruments are made from lightweight, non-magnetic titanium, suitable for both disposable and reusable applications in electrosurgery and microsurgery. Additionally, Kogent Surgical provides repair and restoration services for surgical instruments, ensuring their longevity and functionality. The company's products are available online and distributed globally, reflecting its commitment to superior service and cost-effective solutions for medical professionals.

Euclises Pharmaceuticals, Inc. is a biopharmaceutical company focused on researching, developing, and commercializing innovative medicines for inflammation and oncology. Founded in 2011 and headquartered in Saint Louis, Missouri, the company aims to create novel pain and cancer treatments that demonstrate superior safety profiles compared to existing medications. Euclises Pharmaceuticals leverages groundbreaking inventions from Dr. John Talley, a renowned medicinal chemist known for his development of several approved drugs, including Celebrex. The company's research is centered on compounds that promise enhanced efficacy and safety, positioning Euclises as a significant player in the pharmaceutical industry. It operates out of the BioGenerator Accelerator Labs, fostering a collaborative environment for its innovative pursuits.

Greetabl is an online gift platform that specializes in creating unique and personalized gifts for various occasions. The company allows users to transform their photos into greeting cards that double as gift boxes, enhancing the gifting experience. Customers can select from a variety of items, including gift cards, chocolates, and other thoughtful gifts, all at affordable prices starting at $20. Greetabl's focus on personalization and ease of use makes it simple for individuals to send meaningful presents to their loved ones.

FocalCast LLC, founded in 2013 and located in St. Louis, Missouri, is a technology company that specializes in developing an interactive web-based platform for market research. The platform allows users to simultaneously share and annotate documents and whiteboards in real time from any device, enhancing collaboration for global brands and marketing agencies. FocalCast's offerings include tools for stimuli and content presentation, live annotations, project management, and polling and data services. Users can easily connect with research participants without needing to download additional software, facilitating seamless presentations directly from smartphones or tablets to display devices like projectors or smart TVs.

Radialogica LLC, established in 2011 and headquartered in St. Louis, Missouri, is a healthcare information technology company specializing in radiation oncology software solutions. The company's flagship product, fullAccess, is an integrated platform enabling clinicians across various care settings to access, analyze, and share radiotherapy treatment plans, diagnostic images, and other patient data. This platform also facilitates content delivery, course instruction, and student assessment for academic programs associated with radiation oncology. Additionally, Radialogica offers OncoInformatix, a web-based tool for radiotherapy treatment data acquisition, aggregation, analysis, and reporting. The company serves healthcare providers and payers in the United States.

SmashToast, Inc. is a company founded in 2014 and based in Rochester, Illinois, with a customer service center in Austin, Texas. It specializes in developing innovative hardware and software solutions that enhance home automation. The company has created a Bluetooth-enabled device that allows users to control various household electronics, such as televisions, sound bars, air conditioners, and space heaters, directly from a mobile application. This technology eliminates the need for multiple remotes and reduces wiring complications, enabling seamless integration and control of home devices from a smartphone.

Galera Therapeutics, Inc. is a clinical-stage biopharmaceutical company headquartered in Malvern, Pennsylvania, dedicated to developing innovative therapeutics aimed at enhancing the effectiveness of radiotherapy for cancer patients. The company's lead product candidate, avasopasem manganese (GC4419), is a small molecule dismutase mimetic currently undergoing Phase III clinical trials for the treatment of radiation-induced severe oral mucositis in patients with head and neck cancer. Additionally, GC4419 is being evaluated in Phase IIa trials for the treatment of radiotherapy-induced esophagitis in lung cancer patients. Galera is also advancing another candidate, GC4711, which is in Phase I/II trials for pancreatic and lung cancers. The company's research is focused on targeting oxygen metabolic pathways to improve patient outcomes in radiation therapy, and GC4419 has received Fast Track and Breakthrough Therapy designations from the U.S. Food and Drug Administration.

Dexer is a heads-up, customized speech application and service that streamlines data collection and accessibility across industries.

Euclises Pharmaceuticals, Inc. is a biopharmaceutical company focused on researching, developing, and commercializing innovative medicines for inflammation and oncology. Founded in 2011 and headquartered in Saint Louis, Missouri, the company aims to create novel pain and cancer treatments that demonstrate superior safety profiles compared to existing medications. Euclises Pharmaceuticals leverages groundbreaking inventions from Dr. John Talley, a renowned medicinal chemist known for his development of several approved drugs, including Celebrex. The company's research is centered on compounds that promise enhanced efficacy and safety, positioning Euclises as a significant player in the pharmaceutical industry. It operates out of the BioGenerator Accelerator Labs, fostering a collaborative environment for its innovative pursuits.

Confluence Life Sciences, Inc. is a drug discovery company based in Saint Louis, Missouri, specializing in the design and development of mechanistically novel kinase inhibitors for human and animal health care. Founded in 2010, the company utilizes its KINect technology platform to identify and develop new drugs targeting key enzymes involved in cancer growth, survival, and metastasis, as well as in chronic inflammatory diseases. Confluence Life Sciences distinguishes itself by focusing on novel binding sites and previously undrugged kinases, addressing challenges that other programs have overlooked. The company is supported by a team of experts with extensive pharmaceutical experience in kinase inhibitor discovery and development, enabling it to pursue innovative strategies and targets. Confluence Life Sciences aims to establish scientific and business collaborations to enhance its program pipeline, which follows a cycle of discovery, development, and partnership to meet unmet medical needs.

CoverCress Inc. is a biotechnology company based in Saint Louis, Missouri, founded in 2013. The company focuses on developing and commercializing field pennycress as an oilseed crop, which is utilized for producing oil for renewable fuels and meal for livestock feed. By genetically improving pennycress, CoverCress aims to create a sustainable cover crop that enhances soil health and offers benefits for farmers during corn and soybean planting seasons. The company’s efforts are centered on sustainable agricultural practices, allowing farmers to maximize yields while minimizing input and carbon emissions. Formerly known as Arvegenix Inc., CoverCress reflects a commitment to innovation in agriculture, biotechnology, and renewable energy solutions.

Euclises Pharmaceuticals, Inc. is a biopharmaceutical company focused on researching, developing, and commercializing innovative medicines for inflammation and oncology. Founded in 2011 and headquartered in Saint Louis, Missouri, the company aims to create novel pain and cancer treatments that demonstrate superior safety profiles compared to existing medications. Euclises Pharmaceuticals leverages groundbreaking inventions from Dr. John Talley, a renowned medicinal chemist known for his development of several approved drugs, including Celebrex. The company's research is centered on compounds that promise enhanced efficacy and safety, positioning Euclises as a significant player in the pharmaceutical industry. It operates out of the BioGenerator Accelerator Labs, fostering a collaborative environment for its innovative pursuits.

GeneriCo, LLC is a pharmaceutical company that specializes in the development and marketing of generic medications. Founded in 2013 and headquartered in Saint Louis, Missouri, with additional offices in Bengaluru, India; Italy; and South Korea, GeneriCo focuses on foundational medicines across various therapeutic areas, including cardiovascular health, pain management, central nervous system disorders, oncology, and aging-related conditions. The company distinguishes itself by targeting niche generic pharmaceuticals that have been overlooked by larger competitors, particularly those that involve complex formulations and innovative drug delivery technologies. This strategic focus allows GeneriCo to address specific market needs that are often neglected by mid-sized and large generic companies. GeneriCo serves a global customer base, providing essential medications that contribute to improved health outcomes.

Benson Hill is an agricultural technology company that specializes in crop improvement and soy protein innovation. The company focuses on unlocking the natural genetic diversity of plants to develop healthier, more sustainable food and ingredients. Its proprietary CropOS platform leverages machine learning and big data alongside traditional breeding techniques to streamline and expedite the product development process. Benson Hill operates a Crop Accelerator designed for rapid prototyping and is actively developing a seed portfolio that includes protein ingredients, aquaculture, specialty animal feed, and vegetable oils. The company generates revenue from both proprietary and non-proprietary product categories, with proprietary revenue stemming from the sale of its unique bean varieties.

RnAgri is a biotechnology company based in St Louis, Missouri, founded in 2011. The company specializes in developing innovative technology for producing ribonucleic acid (RNA). RnAgri's technology tackles challenges associated with mass-producing exogenous RNAi-based products through large-scale fermentation processes. This enables farmers to enhance and safeguard their crops and cattle by providing cost-efficient RNA production solutions.

Cardialen, Inc. is a medical device company based in Minneapolis, Minnesota, that specializes in developing innovative therapies for heart arrhythmias, particularly atrial fibrillation. Founded in 2008, the company focuses on creating implantable devices that provide low-energy, pain-free cardioversion therapies to restore normal heart rhythm. These devices utilize a proprietary technology that delivers a sequential series of low-voltage pulses to effectively address atrial fibrillation and other related conditions, such as rapid ventricular tachycardia and ventricular fibrillation, while minimizing patient discomfort and protecting heart tissue from damage. By targeting significant unmet medical needs, Cardialen aims to improve the quality of life for individuals suffering from these heart conditions.

RnAgri is a biotechnology company based in St Louis, Missouri, founded in 2011. The company specializes in developing innovative technology for producing ribonucleic acid (RNA). RnAgri's technology tackles challenges associated with mass-producing exogenous RNAi-based products through large-scale fermentation processes. This enables farmers to enhance and safeguard their crops and cattle by providing cost-efficient RNA production solutions.

ImmunoPhotonics, Inc. is a biotechnology company focused on developing innovative immunotherapy-based treatments for cancer, specifically targeting metastatic solid tumors. Founded in 2008 and headquartered in Columbia, Missouri, the company has created a proprietary drug product that functions as a minimally invasive autologous cancer vaccine. This treatment involves the intratumoral injection of a carbohydrate polymer following tumor ablation, which harnesses the immune system's response to tumor-associated neoantigens released during the process. By doing so, ImmunoPhotonics aims to generate a systemic anti-tumor immune response, facilitating the treatment of late-stage metastatic cancers. The company has established a strategic partnership with Veterinary Cancer Therapeutics, LLC, enhancing its potential for clinical application.

S4 is a technology service company that provides risk management solutions to ensure food production. It also develops index-based coverage to transfer the agriculture industry's volatilities to the financial markets, through OTC-derivatives contracts. The company offers products and services are used by a broad range of customers including large growers, crop protection and seeds suppliers, crop insurance providers, banking, and commodity exchanges. S4 integrates the harvest information with a planting plan, seed density, and soil analysis. They had developed a decision-making geo-referenced platform for the agricultural producer. They seek to improve the decision-making process in complex environments to collaborate in the global challenge of generating quality food for humanity. S4 was founded on 2011 and is headquartered in Buenos Aires, Argentina.

Elira, Inc. is a neurostimulation company based in St. Louis, Missouri, that specializes in developing a wearable patch aimed at helping overweight adults manage their appetite. Founded in 2015, Elira focuses on providing a drug-free, non-invasive solution that modulates the central nervous system to effectively suppress hunger. By enabling users to gain better control over their eating habits, the company's innovative device supports individuals in achieving their weight management and health goals.

SixPlus is an online platform that enables individuals and corporate event professionals to discover and book private and semi-private venues for group events. The service provides a curated network of venue partners and offers concierge-assisted planning to simplify reservations for board dinners, client dinners, team lunches, and company holiday parties. It supports end-to-end workflow by enabling venue selection, proposal building, bookings, contracts, and communications in a single place. Targeted users include event planners, corporate groups, and marketing directors who organize private dining and other group events, with availability across major U.S. cities such as New York, Washington, DC, Boston, Los Angeles, San Francisco, and Chicago.

Epharmix, Inc. is a digital healthcare company that specializes in developing clinically validated, condition-specific communication tools designed for the healthcare industry. Founded in 2015 and based in St. Louis, Missouri, the company creates digital interventions tailored to various patient populations, aimed at enhancing patient-physician engagement. Epharmix's products facilitate the automatic collection of clinical data over time, which allows for algorithmic alerts to healthcare providers, thereby supporting chronic care management for patients. By focusing on underserved patient groups, Epharmix enables care teams to improve healthcare delivery while reducing workload through proven interventions that enhance both engagement and health outcomes.

Coolfire Solutions, Inc., established in 2010 and headquartered in St. Louis, Missouri, specializes in developing situational awareness technology. The company's flagship product, Ronin, is a mobile-first platform that connects people, assets, and information, enabling swift decision-making and action-taking. Coolfire's patented technology creates a digital workspace, keeping teams organized and informed, serving a diverse range of customers including corporate entities like Enterprise Rent-A-Car and government agencies such as the U.S. Department of Defense.

CellARide is a technology company specializing in automotive marketing solutions and safety recall communications. It has developed an innovative platform that enables clients, including automotive marketers, manufacturers, and advocacy organizations, to engage effectively with consumers. By leveraging widely used mobile messaging technologies, CellARide allows users to create mobile brochures for vehicles, facilitating direct communication with potential buyers. The platform provides intuitive consumer insights, compliant messaging, and robust data capture capabilities, resulting in real-time, actionable information for clients. This approach not only enhances consumer engagement but also streamlines the marketing process for automotive brands and dealerships.

IVDiagnostics, Inc. is a company that specializes in the development, testing, and marketing of diagnostic tools aimed at detecting rare circulating tumor cells (CTCs) and blood-borne diseases. Established in 2010 and headquartered in Crown Point, Indiana, the company offers a range of products, including CTC cancer assays and minimally invasive molecular diagnostics. These tools are designed to diagnose various types of cancer, such as breast, colon, kidney, lung, ovarian, pancreatic cancers, and leukemia. By focusing on CTCs, which are cancer cells that circulate in the blood and can lead to metastasis, IVDiagnostics aims to enhance early cancer detection and improve patient outcomes. Their innovative diagnostic technology allows healthcare professionals to monitor and detect CTCs in real time, providing critical insights without the need for extensive blood tests.

Time to Cater is a web-based platform designed to streamline the catering process for companies and individuals. By allowing clients to submit event details, food preferences, and budgets through its application, the company eliminates the need for time-consuming calls to caterers. The platform manages all aspects of catering coordination, including order placement, caterer selection, menu choices, and quality control, ensuring a seamless experience from start to finish. Clients benefit from this service at no additional cost, as Time to Cater generates revenue by taking a commission from its Preferred Caterer Network. With a focus on efficiency and customer satisfaction, Time to Cater aims to enhance the catering experience for all its users.

PolicyEngage is a provider of workflow automation software tailored for public affairs. The company offers a comprehensive platform that integrates legislative and regulatory surveillance, advocacy engagement, donor involvement, and media monitoring. This software allows clients to streamline their operations by designing a unified workflow for their teams, facilitating effective collaboration and communication. Additionally, PolicyEngage equips users with tools for real-time updates and activity tracking, ensuring that stakeholders receive timely and relevant information. By consolidating various aspects of public affairs into a single system, PolicyEngage enhances the efficiency and effectiveness of organizations in managing their advocacy efforts.

Aisle411 Inc., founded in 2008 and based in St. Louis, Missouri, offers a mobile in-store location services platform for retailers. The company's platform enables shoppers to easily navigate retail stores by mapping products, offers, and lists by aisle location, providing unique information based on the shopper’s in-store location. This enhances the shopping experience by allowing retailers to reach shoppers at the shelf with contextually relevant information. Aisle411 collects, organizes, and monetizes retailers’ product inventory, location data, and enterprise software space planning systems and store maps. The company has partnered with leading indoor positioning technology providers to offer shopper positioning services that drive merchandising insights and engaging shopping experiences, ultimately increasing customer satisfaction and retailer engagement.

Euclises Pharmaceuticals, Inc. is a biopharmaceutical company focused on researching, developing, and commercializing innovative medicines for inflammation and oncology. Founded in 2011 and headquartered in Saint Louis, Missouri, the company aims to create novel pain and cancer treatments that demonstrate superior safety profiles compared to existing medications. Euclises Pharmaceuticals leverages groundbreaking inventions from Dr. John Talley, a renowned medicinal chemist known for his development of several approved drugs, including Celebrex. The company's research is centered on compounds that promise enhanced efficacy and safety, positioning Euclises as a significant player in the pharmaceutical industry. It operates out of the BioGenerator Accelerator Labs, fostering a collaborative environment for its innovative pursuits.

BacterioScan, Inc. is a medical device company based in St. Louis, Missouri, focused on diagnosing and treating infectious diseases. The company has developed the 216Dx UTI System, which detects bacteria indicative of urinary tract infections (UTIs) in clinical urine samples and helps identify suitable antibiotic treatments. Additionally, BacterioScan offers the 216R Antibiotic Susceptibility Testing System, designed to detect bacterial infections, assess antibiotic resistance, and provide clinicians with tailored antimicrobial resistance profiles. Its precision bench-top systems facilitate rapid detection and real-time quantification of microbial growth, significantly enhancing laboratory efficiency compared to traditional plating methods. This innovative approach not only aids clinicians in personalizing patient care but also supports researchers in accelerating the development of new antibiotics. BacterioScan's technology aims to improve the quality of antibiotic therapy and mitigate the risks associated with antibiotic resistance.

Adarza BioSystems is an early-stage medical diagnostics company based in St. Louis, Missouri, that specializes in developing a rapid and label-free biological assay platform for clinical and point-of-care samples. Founded in 2008, the company utilizes its innovative arrayed imaging reflectometry technology to enable the simultaneous detection of hundreds of analytes from a single drop of fluid. This platform allows healthcare professionals to conduct sophisticated tests in a matter of minutes, ensuring high sensitivity and specificity in the detection of multiplexed proteins. Adarza BioSystems aims to enhance diagnostic capabilities, improving patient outcomes through quicker and more accurate testing.

Acera Surgical, Inc., founded in 2014, specializes in developing a range of fully synthetic surgical materials that serve as resorbable scaffolds for repairing and regenerating soft tissue. Their products aim to enhance surgical efficiency, minimize complications and costs, and promote superior clinical outcomes by mimicking the structure and function of human tissue.

Elemental Enzymes Inc. is a manufacturer based in Columbia, Missouri, specializing in the production of enzymes designed to function in harsh environments, both in outdoor settings and industrial applications. The company offers a diverse range of enzyme products, including those for agricultural use, environmental remediation, and fuel production. Their offerings include enzymes that degrade cellulose, starches, and sugars, stable alternatives to caustic chemicals for digesting fracking gels, and solutions for converting CO2 into carbonate for capture or sale. Additionally, Elemental Enzymes develops customized enzyme solutions to address common environmental contaminants and creates enzymes for various non-environmental applications. The company was originally established as Spogen Biotech, Inc. in 2011 before rebranding to its current name.

Akermin, Inc. is a biocatalyst development company based in St. Louis, Missouri, founded in 2003. The company specializes in innovative solutions for the removal of carbon dioxide (CO2) from industrial gas streams, utilizing biocatalysis and nanotechnology. Akermin has developed proprietary delivery systems that enable the integration of enzymes into traditional chemical absorption processes for effective CO2 removal. In addition to its primary focus on carbon capture, Akermin is also exploring applications of its stabilized enzyme technology in various sectors, including food processing, biofuels, chemicals, and pharmaceuticals. The company aims to commercialize its technology, which originated from research at Saint Louis University, and has demonstrated its capabilities in developing sustainable solutions for a range of industries.

Tunespeak, LLC is a loyalty platform that connects musicians with their fans by allowing users to earn points through various activities such as listening to music, watching videos, checking photos, and sharing content with friends and followers. Founded in 2011 and based in St. Louis, Missouri, Tunespeak facilitates engagement between artists and audiences by rewarding fans for their participation. The platform enhances the fan experience by providing opportunities to earn rewards like tickets, unique experiences, and merchandise, thereby fostering a deeper connection between musicians and their supporters.

BenchmarkONE is a St. Louis, Missouri-based company that specializes in developing sales and marketing automation software for small and mid-sized businesses. Founded in 2010 and previously known as Hatchbuck, Inc., BenchmarkONE provides an all-in-one customer relationship management (CRM) platform that includes features for sales automation, real-time activity monitoring, and email marketing. Its user-friendly interface allows businesses to create and manage campaigns, track leads, and analyze performance metrics effectively. The software is designed to streamline the sales process, enhance customer engagement, and facilitate the growth of relationships into sales. As of June 2020, BenchmarkONE operates as a subsidiary of Benchmark Internet Group, LLC.

NeuroLutions Inc., established in 2007 and headquartered in St. Louis, Missouri, specializes in developing non-invasive brain-computer interface (BCI) devices. These devices utilize electroencephalography (EEG) technology to interpret intended muscle movements from the brain, enabling stroke survivors to restore lost arm function and improve range of motion through muscle re-education. The company aims to revolutionize neurorehabilitation by providing a non-invasive alternative to traditional invasive BCI therapies.

Cardialen, Inc. is a medical device company based in Minneapolis, Minnesota, that specializes in developing innovative therapies for heart arrhythmias, particularly atrial fibrillation. Founded in 2008, the company focuses on creating implantable devices that provide low-energy, pain-free cardioversion therapies to restore normal heart rhythm. These devices utilize a proprietary technology that delivers a sequential series of low-voltage pulses to effectively address atrial fibrillation and other related conditions, such as rapid ventricular tachycardia and ventricular fibrillation, while minimizing patient discomfort and protecting heart tissue from damage. By targeting significant unmet medical needs, Cardialen aims to improve the quality of life for individuals suffering from these heart conditions.

Kypha Inc. is a life sciences company focused on the discovery, development, and commercialization of in-vitro diagnostic biomarker tests targeting inflammation and autoimmune disorders. Based in St. Louis, Missouri, the company offers the COMP ACT System, which enhances the monitoring and treatment of various health conditions, including lupus, stroke, traumatic brain injury, preeclampsia, infection, kidney disease, and transplant rejection. Through its innovative platform, Kypha provides rapid and accurate assessments of inflammation levels, enabling healthcare professionals to make timely and informed clinical decisions. The company's approach facilitates testing across diverse settings, from home health care to clinical laboratories, ultimately aiming to improve patient outcomes by optimizing treatment strategies based on real-time immune insights. Since its incorporation in 2009, Kypha has attracted significant funding and built a strong network of scientific and clinical expertise to support its mission.

Decide operates an interest-based social platform that caters to various topics, including gaming, music, and politics. The company provides native advertising solutions that allow brands to effectively engage with their target audiences. It offers tools for audience development, such as polls, contests, quizzes, and feedback mechanisms, enabling publishers to activate user engagement through customizable actions like newsletter subscriptions and social media follows. Additionally, Decide assists in campaign planning, content creation, and performance optimization, while allowing real-time measurement of results. The platform leverages an in-house artificial intelligence, known as Neo, which utilizes machine learning to analyze vast amounts of data and make informed advertising decisions. Founded in 2008 and headquartered in Saint Louis, Missouri, with an additional office in New York, Decide aims to enhance the advertising experience by connecting advertisers with relevant publishers and users.

Euclises Pharmaceuticals, Inc. is a biopharmaceutical company focused on researching, developing, and commercializing innovative medicines for inflammation and oncology. Founded in 2011 and headquartered in Saint Louis, Missouri, the company aims to create novel pain and cancer treatments that demonstrate superior safety profiles compared to existing medications. Euclises Pharmaceuticals leverages groundbreaking inventions from Dr. John Talley, a renowned medicinal chemist known for his development of several approved drugs, including Celebrex. The company's research is centered on compounds that promise enhanced efficacy and safety, positioning Euclises as a significant player in the pharmaceutical industry. It operates out of the BioGenerator Accelerator Labs, fostering a collaborative environment for its innovative pursuits.

Bonfyre Inc. is an employee engagement platform founded in 2013 and based in Saint Louis, Missouri. The company focuses on enhancing workplace culture by providing tools for employee recognition, communications, feedback, and event management. Its technology aims to reshape the employee experience through mobile-first, real-time communication features, such as announcements, targeted broadcasts, and pop surveys. By fostering camaraderie and aligning organizational culture, Bonfyre helps enterprises increase employee engagement and build collaborative, innovative environments.

Traxxsson is a biotechnology company that develops diagnostics for cancer using protein biomarkers. It uses a proprietary panel of biomarkers to identify at-risk patients who have questionable radiology images. It has three tests: PRO CancSure to identify prostate cancer patients in need of aggressive treatment, BRE CancSure to confirm the presence of breast cancer in women with positive mammograms, and LNG CancSure to confirm the presence of lung cancer in patients with positive low-density CAT scan results. The company was founded in 2009 and is based in St. Louis, Missouri.

Nawgan offers a brain-friendly functional beverage developed to provide both long and short-term benefits for the brain. Nawgan contains citicoline (a combination of choline and cytidine); Alpha-GPC (Alpha-glyceryl phosphorylcholine – claimed to increase acetylcholine in the brain); lycopene; caffeine (100mg); and natural vitamin E. Unlike many products in the cognitive function market, claims made by Nawgan were supported by research on the end product rather than extrapolations based on literature about individual ingredients.

Euphrates Vascular is a medical technology company based in St. Louis, Missouri, that focuses on innovative solutions for the treatment of stroke, heart disease, and other conditions. The company has developed a proprietary magnetically-enhanced diffusion (MED) system that utilizes magnet-based technology to dissolve blood clots more rapidly than existing treatment options. This system aims to improve the efficacy of FDA-approved clot-busting medications, potentially reducing mortality rates associated with stroke and cardiovascular diseases. In addition to the MED system, Euphrates Vascular offers MED MicroBeads, which are designed to deliver therapeutic agents directly to clots during thrombolysis therapy, and a touch screen-operated MED Workstation. Founded by physicists with extensive experience in medical technology, the company continues to advance its pioneering approaches in the healthcare sector, attracting interest from investors and media alike.

Katalyst Surgical, LLC is a manufacturer of ophthalmic surgical instruments, specializing in providing innovative tools designed to enhance surgical techniques, particularly for membrane peeling. Founded in 2010 and based in Chesterfield, Missouri, the company offers a comprehensive range of products, including cannulas, forceps, hooks and manipulators, LASIK instruments, needle holders, phaco choppers, scissors, speculums, and other related items. Katalyst Surgical is committed to enabling medical practitioners to perform surgical procedures more effectively through its high-quality, specialized instruments.

Somark Innovations specializes in advanced lab animal identification solutions, focusing on chip-less radio frequency identification tattoos. These innovative tattoos enhance the accuracy and consistency of animal identification, thereby safeguarding the integrity of the chain of custody in research settings. By promoting animal and data welfare, Somark Innovations contributes to improved scientific outcomes for researchers and supports businesses engaged in research advancements. In addition to its core offerings in animal identification, the company also provides inventory management solutions for various sectors, including automotive parts, documents, and casino chips.

Akermin, Inc. is a biocatalyst development company based in St. Louis, Missouri, founded in 2003. The company specializes in innovative solutions for the removal of carbon dioxide (CO2) from industrial gas streams, utilizing biocatalysis and nanotechnology. Akermin has developed proprietary delivery systems that enable the integration of enzymes into traditional chemical absorption processes for effective CO2 removal. In addition to its primary focus on carbon capture, Akermin is also exploring applications of its stabilized enzyme technology in various sectors, including food processing, biofuels, chemicals, and pharmaceuticals. The company aims to commercialize its technology, which originated from research at Saint Louis University, and has demonstrated its capabilities in developing sustainable solutions for a range of industries.

Appistry Inc. is a bioinformatics company based in St. Louis, Missouri, that specializes in developing tools and cloud services for healthcare institutions to enhance genomically informed medicine. Founded in 2001 and originally known as Tsunami Research, Appistry provides a suite of solutions that streamline the analysis of next-generation sequencing (NGS) data, making it accessible and actionable for clinical laboratories, research institutions, and hospitals. Its flagship offerings include Appistry CloudDx, which supports patient-centered translational research and facilitates the integration of genome-scale tests into routine clinical practice. Additionally, the company offers tools for analyzing whole genomes, exomes, and tumor-normal pair data, as well as platforms like GenomePilot and the Cancer Genome Analysis Suite, which organize and execute complex NGS analyses. By leveraging cloud architecture, Appistry addresses the challenges of large-scale data storage and processing, enabling rapid transformation of raw genomic data into actionable insights that inform clinical decisions and research initiatives.