St. Louis Arch Angels

St. Louis Arch Angels is an angel investment group focused on providing seed, startup, and early-stage capital primarily within the St. Louis region. Established in January 2005 and based in St. Louis, Missouri, the group invests between $25,000 and $100,000 per individual transaction, with collective investments ranging from $250,000 to $750,000. The organization aims to support high-potential startups from the local ecosystem, thereby enhancing the region's capacity to finance innovation. St. Louis Arch Angels seeks to fill the funding gap often overlooked by institutional venture capital firms, retaining investments for up to eight years to foster the growth and success of their portfolio companies.

Brian Kinman

Chairman

70 past transactions

SentiAR

Venture Round in 2021
SentiAR is digital health, software device company adding a new dimension to clinical practice in interventional procedures. Spun out of Washington University, it develops a 3D visualization platform using real-time holography of the patient's anatomy and catheter location, over the patients, with the goal of providing the clinician and patient a faster, safer delivery of care. SentiAR’s mission is to transform the experience for both patient and clinician in interventional procedures with a 3D augmented reality platform featuring real-time holographic visualization of the patient’s actual anatomy, over the patient. The visualization is fully controllable by the clinician, providing an ergonomic breakthrough for the treatment and analysis of cardiac arrhythmias within an interventional catheter lab environment. SentiAR is developing the platform for eventual FDA submission.

Impetus Agriculture

Seed Round in 2021
Impetus Agriculture focuses on developing multiple topical or transgenic insect control products. Products that are safe, effective, and sustainable. Products that are not subject to the same insect resistance that has developed in current commercial products.

Sequoia Sciences

Seed Round in 2020
Sequoia Sciences is a pharmaceutical company discovering and developing new medicines for the treatment of bacterial infections and cancers. Their development programs consist of small molecules targeting bacterial infections and cancers, and also vaccines for the treatment and prevention of recurrent urinary tract infections. Their goal is to improve the quality of life for those individuals significantly affected by recurrent and chronic bacterial infections and cancers. Sequoia is engaged in research and development programs and collaborations with laboratories, universities, clinical research sites, and private businesses. They have applied their microscale structure determination expertise to elucidate structures of natural products, biosynthetic intermediates, and unexpected synthetic products for academic and industrial collaborators.

Amplified Sciences

Seed Round in 2020
Amplified Sciences is a molecular diagnostics company unlike other diagnostics companies due to their ultra-sensitive molecular sensing technology with composition of matter IP exclusively licensed from Purdue University. The technology is disease state agnostic, can detect to the single molecule level, scales easily to point of care, and provides a very favorable cost structure for their platform of reagents. The first application – early detection of pancreatic cancer - is an assay that will quickly prove the investment thesis due to large unmet medical need and a favorable reimbursement path. The team has delivered a working prototype and published proof of concept data.

Covercress

Venture Round in 2020
CoverCress is a biotechnology company that focuses on research and development of renewable fuel and livestock feed. It specializes in producing an oilseed crop for food, bioenergy, and cattle feed. It specializes in the fields of agriculture, biotechnology, plants, genetics, cover crop, and precision agriculture. CoverCress was founded in 2013 by Jerry Steiner and Dr. Tim Ulmasov and is headquartered in St. Louis Missouri.

FinLocker

Venture Round in 2019
FinLocker is a financial services technology innovator, founded by a team of veterans and executives across the financial services and technology industries. It provides a personal financial assistant tool that enables loans and financial transactions. With consumer consent, FinLocker captures key borrower data and applies intelligent analytics such as loan product recommendations based on a consumer’s financial profile, asset and income verification, and more. The company was founded in 2014 and is headquartered in St Louis, Missouri.

Ryvit

Seed Round in 2019
Ryvit develops an integration software that delivers seamless flow of data between premise and software used in the construction industry. The software integrates software application to enterprise resource product, customer relationship management, e-commerce, social apps, and specialty industry-specific system without exhausting development resources, empowering companies to experience the ease of intelligent integrations, driving profit through automation and optimization of the applications in use. Ryvit is headquartered in Saint Louis, Missouri.

IDEATE Medical

Series A in 2019
IDEATE Medical develops sterilization technology for the safe and rapid terminal sterilization of all endoscopic devices. The mission of IDEATE Medical is to lower the infection risk from the 75 million endoscope procedures conducted in the U.S. each year. IDEATE Medical understands the importance of efficacy, compatibility, and throughput and has developed a unique, innovative, low-temperature sterilization technology for the safe and rapid terminal sterilization of all endoscopic devices for every procedure. Our technology utilizes the benefits of Vapor Hydrogen Peroxide (VHP) sterilization technology but incorporates key innovations to address the specific challenges associated with the terminal sterilization of long multi-channel endoscopic medical devices. With its innovations, the most challenging endoscopic devices can be terminally sterilized in 30 minutes with no impact on the endoscopic device.

Balance the Superfood Shot

Seed Round in 2018
Life Equals is a health supplement startup which sells vitamins and supplement products. Its first product line is premium health and nutrition products which focus on preventative health using bio-available and whole food blends. The company was founded in 2011 and is based in Kansas City.

CheckTheQ

Seed Round in 2018
CheckTheQ provides real-time line information to airport management, allowing them to optimize operations and, ultimately, reduce wait times. They are the first affordable and effective solution designed to provide real-time data-driven insights to small, regional, and international airports in order to expedite security, improve the traveler experience, and ultimately increase the airport's bottom line.

ProteoSense

Seed Round in 2018
PROTEOSENSE LLC is a recognized leader on the local market, and we have every right to be proud of this fact. The driving force behind our reputation is our employees, who have invested a lot of energy in the development of our business. We place primary importance on the personal and professional development of each of them, and we try to give our employees every opportunity to better themselves. We place primary importance on the personal and professional development of each of them, and we try to give our employees every opportunity to better themselves.

Rozzy Learning Company

Seed Round in 2018
Rozzy Learning Company mission is to bring hands-on STEAM (Science, Technology, Engineering, Art, Math) programs and resources to young learners and teachers to promote curiosity, critical thinking skills, and exploration. They focus on STEAM careers because they are the fastest growing, highest paying jobs in the world. By introducing kids to STEAM early on, you are setting them up for success in and outside of school. Unlike other STEAM companies, they have affordable programs that don‘t require expensive technology or materials. Bonus? Their programs fit into teachers’ busy schedules!

Viosera Therapeutics

Seed Round in 2018
Viosera Therapeutics is a predict and block drug resistance in cancer and bacteria. The company discovers synergies between approved drugs and develop combinations of drugs that suppress resistance. Antibiotic resistance makes it necessary to develop better treatments for deadly infections. Viosera Therapeutics was founded in July 2016 and is headquartered in Sunnyvale, California.

Kalocyte

Seed Round in 2018
Kalocyte is a pre-clinical stage healthcare biotech startup company that provides artificial red blood cell substitutes used for trauma care related services. The company develops a demonstrated proof of concept for ErythroMer, a dried, bio-inspired artificial red blood cell envisioned for use when stored red blood cells are unavailable, undesirable, or in short supply. Kalocyte was founded in 2016 and is headquartered in Baltimore, Maryland.

Lean Media

Seed Round in 2018
Lean Media is an audience-first programmatic online advertising company that delivers confidence to advertisers in markets. It provides cookieless audience targeting for online display advertising that uses consumer psychographic, demographic, and behavioral insights combined with geo-targeting technology to improve engagement and reduce waste.

Transactly

Pre Seed Round in 2018
Transactly is a real estate technology platform that organizes and coordinates the process of closing a real estate transaction. It is the first tech-enabled transaction coordinator service, and it is nationwide. When hiring them, customers will have their own dedicated and highly reviewed coordinator, along with an entire company supporting them and their business. It was founded in 2018 and is headquartered in St. Charles, Missouri.

SwipeSum

Angel Round in 2018
SwipeSum is a technology aimed at reducing credit card and debit card processing fees for companies. The fees associated with accepting card payments are US business owners’ second-highest operating expense behind labor, a $70 billion burden annually. Payments are very complicated, making it difficult for businesses to find the best fit for their unique business, not to mention the headache that comes with negotiating terms. SwipeSum is an extension of any business's product and financial team, we’re payments consultants leveraging proprietary software to optimize payments. We are your Chief Payments Officer For Businesses: At no cost to the business, SwipeSum will eliminate most fees associated with payments or turn them into a lucrative revenue stream. We do this by leveraging our proprietary technology and expertise. In 2019 we advised over $8B in processing volume. We are very transparent that we receive earn our revenue as a recurring finders fee from any and all payments companies that we refer. For Payment Facilitators or Integrated Software Vendors If your software needs integrated payments, that is our specialty. With the advancement of payments technologies, product improvement is our focus. SwipeSum also leverages strength in numbers to get all software vendors the most lucrative partnership agreements. For Financial Institutions The secret sauce behind our consultation platform is our AI-powered statement reading technology, named Staitment. We license this software to banks, processing companies, point-of-sale dealers, and anyone that analyses processing statements to create cost-comparison sales proposals. Our software accelerates the typical creation of a cost-comparison to minutes, compared to weeks.

Aptimmune

Series B in 2018
Aptimmune is a biotechnology company that focuses on developing a muscoal vaccine against viral diseases swine. It focuses on swine vaccines and the prevention of two major diseases, Porcine Reproductive and Respiratory Syndrome virus (PRRSV) and influenza. It utilizes novel technologies to create effective nasal delivery vaccines against PRRSV such as the proprietary pig alveolar macrophage cell line ZMAC. The company was founded in 2010 and headquartered in St. Louis, Missouri.

Covercress

Venture Round in 2017
CoverCress is a biotechnology company that focuses on research and development of renewable fuel and livestock feed. It specializes in producing an oilseed crop for food, bioenergy, and cattle feed. It specializes in the fields of agriculture, biotechnology, plants, genetics, cover crop, and precision agriculture. CoverCress was founded in 2013 by Jerry Steiner and Dr. Tim Ulmasov and is headquartered in St. Louis Missouri.

NexMatix

Seed Round in 2017
Nexmatix creates Savings Out of Thin Air by reducing the cost of your pneumatic systems with energy efficient products that reduce your carbon footprint.Nexmatix first product line targets one of the most inefficient pneumatic components on the market, directional control valves.

Kogent Surgical

Seed Round in 2017
Kogent Surgical is the industry leader in neurosurgical instruments. Our experienced team has over 40 years of design, manufacturing, and quality control of neurosurgery products. It is our goal to provide superior service paired with high quality neurosurgical instruments at a cost saving to our customers.

Cardiaform

Seed Round in 2017
Cardiaform is a medical device company developing devices to diagnose and treat cardiovascular disease. Its devices will enable instantaneous high density, high definition electrical maps to support mapping unstable arrhythmias (ventricular tachycardia), reduce procedure time from 3-4 hours to less than 1 hour, and provide improved procedural success using only a single catheter.

Euclises Pharmaceuticals

Venture Round in 2016
Euclises Pharmaceuticals, Inc is developing novel pain and cancer medications that offer superior safety margins compared to existing drugs. The company is based on new inventions from Dr. John Talley, the most accomplished medicinal chemist in the world. Dr. Talley previously invented Celebrex and seven other approved drugs. New compounds from Euclises will offer both improved efficacy and safety relative to existing therapies. Euclises is located at the BioGenerator Accelerator Labs.

Greetabl

Seed Round in 2016
Greetabl makes it incredibly easy to send unique and personalized gifts that your people will love. In a few clicks, turn your photos into a greeting card that doubles as a gift box. Select from gift cards, chocolates and more to complete your perfect gift (starting at $20!).

FocalCast

Seed Round in 2016
FocalCast offers a range of interactive web-based market research platforms for global brands and marketing agencies. FocalCast was founded by Devin Turner and Charlie Beckwith in September 2013 and is based in St Louis, Missouri.

Radialogica

Venture Round in 2016
Radialogica is a healthcare information technology company that provides software solutions for radiation oncology and the healthcare market. It offers fullAccess, an integrated radiotherapy data display, communication, and analysis platform that enables clinicians across the continuum of care to access, analyze, and share radiotherapy treatment plans, diagnostic images, and other patient data. The company’s platform consists of various licensing modules, including fullView, a vendor-independent RT visualization environment that allows clinicians to view images and treatment plans across various radiotherapy treatment modalities, delivery devices, and planning systems; fullReport tools to analyze and benchmark treatment plans, and automatically extract user-defined dosimetric parameters for retrospective analysis; and fullExchange tools to annotate, package, and share diagnostic images and treatment plans with clinicians and other vested stakeholders inside and outside the clinic. It serves physicians, physicists, dosimetrists, payers, and patients in the United States. The company was incorporated in 2011 and is based in Clayton, Missouri.

SmashToast

Seed Round in 2016
We help you control your home from your phone. Simply Place PUCK on your electronics and control them with your phone. No more remotes, no more wires, and no more line-of-sight limitations.

Galera Therapeutics

Series B in 2016
Galera Therapeutics, Inc. is a privately held, clinical-stage biotechnology company focused on discovering and developing novel therapeutics targeting oxygen metabolic pathways with the potential to transform how radiation therapy is used in patients with cancer. Galera’s lead product candidate is GC4419, a highly selective and potent small molecule superoxide dismutase enzyme mimetic that rapidly converts superoxide to hydrogen peroxide and oxygen. GC4419 achieved positive results in a Phase 2b clinical trial, which demonstrated its ability to reduce the incidence and duration of radiation-induced severe oral mucositis in patients with head and neck cancer, it's lead indication. The U.S. Food and Drug Administration granted Fast Track and Breakthrough Therapy designations to GC4419. The company was established in 2009 and is headquartered in Malvern, Pennsylvania, United States.

Dexer

Seed Round in 2016
Dexer is a heads-up, customized speech application and service that streamlines data collection and accessibility across industries.

Euclises Pharmaceuticals

Venture Round in 2015
Euclises Pharmaceuticals, Inc is developing novel pain and cancer medications that offer superior safety margins compared to existing drugs. The company is based on new inventions from Dr. John Talley, the most accomplished medicinal chemist in the world. Dr. Talley previously invented Celebrex and seven other approved drugs. New compounds from Euclises will offer both improved efficacy and safety relative to existing therapies. Euclises is located at the BioGenerator Accelerator Labs.

Confluence Life Sciences

Series B in 2015
CLS is a drug discovery company focusing on rational drug design to discover and develop mechanistically novel kinase inhibitors for use in both human and animal health care. CLS’s kinase inhibitors target key signal transduction enzymes involved in the regulation of cancer growth and survival, or in the modulation of chronic inflammation. Unlike many other kinase inhibitor programs, however, CLS is targeting novel binding sites (on kinase targets that have proved challenging) as well as previously “un-drugged” kinases. Driving CLS success in this effort is a team of world-class experts with extensive Pharma experience in kinase inhibitor discovery and development. CLS provides this team with the opportunity to pursue strategies and targets outside Pharma’s traditional focus. In addition, scientific and business collaborations are being established to enable the success of the business. The strategy is to develop and maintain a program pipeline: discover, develop, partner, repeat.

Covercress

Series A in 2015
CoverCress is a biotechnology company that focuses on research and development of renewable fuel and livestock feed. It specializes in producing an oilseed crop for food, bioenergy, and cattle feed. It specializes in the fields of agriculture, biotechnology, plants, genetics, cover crop, and precision agriculture. CoverCress was founded in 2013 by Jerry Steiner and Dr. Tim Ulmasov and is headquartered in St. Louis Missouri.

Euclises Pharmaceuticals

Series A in 2015
Euclises Pharmaceuticals, Inc is developing novel pain and cancer medications that offer superior safety margins compared to existing drugs. The company is based on new inventions from Dr. John Talley, the most accomplished medicinal chemist in the world. Dr. Talley previously invented Celebrex and seven other approved drugs. New compounds from Euclises will offer both improved efficacy and safety relative to existing therapies. Euclises is located at the BioGenerator Accelerator Labs.

RNAgri

Seed Round in 2015
RNAgri designs an innovative technology that produces ribonucleic acid. The company's technology addresses some of the challenges to the mass production of exogenous RNAi-based products using a large scale fermentation process, enabling farmers to protect and improve their crops and cattle. The company was founded in 2011 and is headquartered in St Louis, Missouri.

GeneriCo

Seed Round in 2015
GeneriCo is focused on developing and marketing niche generic pharmaceuticals that have been neglected by mid and large generic companies and also have an embedded drug delivery technology. The combination of neglected, technically challenging formulation, and economic size makes the GeneriCo pipeline not appealing to middle and large competitors, and too complex for tightly focused small generic companies.

Benson Hill

Seed Round in 2015
Benson Hill is a crop improvement company that unlocks the natural diversity of plants and empowers innovators with a revolutionary crop design platform to develop healthier and more sustainable food and ingredients. Benson Hill empowers innovators to develop more healthy, flavorful, and sustainable food by unlocking the natural genetic diversity of plants. Benson Hill’s CropOS™ platform combines machine learning and big data with breeding techniques and plant biology to drastically accelerate and simplify the product development process.

CardiaLen

Series B in 2015
CardiaLen develops and commercializes pain-free cardioversion therapies for atrial fibrillation. The company is developing implantable low-energy (low voltage) pain-free atrial cardioverters to help address the major unmet needs of this condition. It was founded in 2008 and headquartered in Minneapolis, Minnesota.

RNAgri

Seed Round in 2015
RNAgri designs an innovative technology that produces ribonucleic acid. The company's technology addresses some of the challenges to the mass production of exogenous RNAi-based products using a large scale fermentation process, enabling farmers to protect and improve their crops and cattle. The company was founded in 2011 and is headquartered in St Louis, Missouri.

ImmunoPhotonics

Series A in 2015
ImmunoPhotonics develops immunotherapy-based treatments for cancer. A minimally invasive therapeutic cancer vaccine for the treatment of metastatic solid tumors. ImmunoPhotonics has a strategic partnership with Veterinary Cancer Therapeutics, LLC. The company was founded in 2008 and is based in Columbia, Missouri.

SixPlus

Seed Round in 2015
SixPlus is trusted by corporate event & administrative professionals to find and book private dining spaces online. From board dinners to team lunches and company holiday parties, our clients use SixPlus to select the best venues and manage their bookings, contracts and communication in one place. Browse venues, build your own proposals and book venues online in New York, Washington DC, Boston, Los Angeles, San Francisco & Chicago.

Epharmix

Seed Round in 2015
Epharmix is a digital healthcare company that creates clinically validated and condition-specific communication tools. It helps care teams automatically monitor underserved patients to improve care & reduce workload with interventions proven to impact engagement and outcomes. It was founded in 2015 and headquartered in St Louis, Missouri.

Elira

Seed Round in 2015
Elira is a developer of a drug-free wearable device designed to help people gain control over their weight. The company's device provides a non-invasive modulation of the central nervous system by safely and effectively suppressing appetite, enabling patients to achieve their health and lifestyle goals. Elira was founded in 2015 and is headquartered in St Louis, Missouri, USA.

Coolfire

Seed Round in 2014
Coolfire builds collaboration software for teams on the move. Coolfire’s patented technology connects people, processes, and information in a purpose-built digital workspace. Coolfire’s vision is to keep teams organized around the work at hand and provide them with the critical information they need to keep moving forward. Coolfire is a trusted technology resource for corporate and government customers from Enterprise Rent-A-Car to the US Department of Defense. For more information, visit https://www.coolfiresolutions.com.

CellARide

Seed Round in 2014
CellARide has built its award-winning technology from the ground up while establishing itself as a leader in client-driven solutions for automotive marketing technology and safety recall communications. CellARide works directly with automotive marketers, manufacturers, mass media groups, national advocacy organizations and coalitions to identify and capture dynamics of consumer behavior, providing effective methods of consumer engagement. CellARide provides clients with an intuitive consumer insights, compliant communications and data capture platform. CellARide’s solutions use broadly adopted mobile messaging technologies to reach consumers directly and provide real-time, actionable data for clients.

IV Diagnostics

Private Equity Round in 2014
Cancer cells spread through the circulatory system as “circulating tumor cells” (CTCs) and represent unique diagnostic targets. CTCs are released from primary tumors into blood circulation and then lodge at distant organs to initiate new cancer growth. Thus circulating tumor cells constitute the major cause for mortality among cancer patients. Recent advancements in detection and characterization of CTCs can have a significant impact on early cancer detection. For instance, the quantization of CTCs can be used for prognosis of the outcomes of metastatic diseases. In another example, identification of cancer stem cells, a subpopulation of CTCs believed to be tumorigenic, can be used for identifying metastasis and recurrence of disease.

Time To Cater

Angel Round in 2014
Time To Cater is a web-based platform that helps companies and individuals coordinate their ideal catered even at NO EXTRA COST to client. If you have had to coordinate catering for events or if you need food ordered quickly online, and especially if you have done it consistently, you understand that valuable time is wasted calling potential caterers for availability, prices, and delivery details, etc. We fix this problem by providing a web-based platform and mobile app that helps companies and individuals coordinate their ideal catered event. Our client only has to submit their event details and budget to our web application and then show up for the event and enjoy! We take care of EVERYTHING in between. And the BEST part is that there is NO EXTRA COST to our client for our service! We make money by making a commission from the caterers in our Preferred Caterer Network.

TrackBill

Seed Round in 2014
TrackBill provides government affairs professionals with efficient mobile access to state and federal legislative information. It serves a diverse clientele, including professional service firms, corporations, and interest groups, enabling them to monitor bills relevant to their interests and track legislative activities. Users benefit from real-time alerts on key actions such as introductions, amendments, hearings, and votes. Additionally, TrackBill simplifies legislative reporting by allowing users to generate professional documents in Word, PDF, and Excel formats, as well as customizable, auto-updating website feeds. This functionality ensures that stakeholders remain informed about important legislative developments.

Aisle411

Series A in 2013
Founded in April of 2008 and based in St. Louis, MO, aisle411 is a trusted indoor location services platform for major global leading retailers. For shoppers, aisle411 makes shopping in-stores easier, allowing them to map products, offers and lists by aisle location, as well as discover unique information based on a shopper’s in-store location. For retailers, aisle411 offers a mobile in-store location services platform that allows them to reach shoppers at the shelf, with context and location relevant information that enhances the shopper experience. aisle411’s proprietary, first-of-its-kind indoor retail mapping and location service and mobile platform allows shoppers to easily navigate through retail stores to find exactly what they want quickly by collecting, organizing and monetizing retailers’ product inventory, location data, and enterprise software space planning systems and store maps. aisle411 has also partnered with leading indoor positioning technology providers to provide shopper positioning services that drive merchandising insights and allow for engaging shopper experiences. The service ultimately drives higher customer satisfaction and a deeper level of engagement between the retailers and its customers by —simplifying the shopping experience.

Euclises Pharmaceuticals

Seed Round in 2013
Euclises Pharmaceuticals, Inc is developing novel pain and cancer medications that offer superior safety margins compared to existing drugs. The company is based on new inventions from Dr. John Talley, the most accomplished medicinal chemist in the world. Dr. Talley previously invented Celebrex and seven other approved drugs. New compounds from Euclises will offer both improved efficacy and safety relative to existing therapies. Euclises is located at the BioGenerator Accelerator Labs.

Bacterioscan

Series A in 2013
BacterioScan is a precision bench-top system that enables rapid detection and real-time quantification of microbial growth. It eliminates workflow bottlenecks and the inherent inaccuracies of legacy plating procedures. Its technology is helping clinicians personalize medicine for patients, and it’s helping researchers bring new antibiotics to market faster and more economically. The potential applications are far-ranging, offering considerable advantages for any microbiology laboratory that can benefit from rapid detection and real-time quantification of bacterial growth, as well as BacterioScan’s space-saving bench-top footprint and its rapid return on investment.

Adarza BioSystems

Seed Round in 2013
Adarza BioSystems is an early-stage medical diagnostics company developing a rapid and label-free biological assay platform for measuring clinical and point-of-care (POC) samples. In addition to performing sophisticated clinical tests within minutes, this technology potentially allowing hundreds of tests to be run simultaneously on a single chip. It was founded in 2008 and headquartered in St Louis, Missouri.

Elemental Enzymes

Seed Round in 2013
Elemental Enzymes is an enzyme manufacturer based in Columbia, MO. We specialize in the production of enzymes specifically designed for survival and activity in harsh conditions, whether outdoors or in industrial processes. In addition, we create customized enzyme solutions for common contaminants found in the environment, as well as the creation and production of enzymes for non-environmental applications.

Acera Surgical

Seed Round in 2013
Acera Surgical, Inc. has developed a portfolio of fully synthetic surgical materials that act as resorbable scaffolds for soft tissue repair and regeneration. Acera's products are designed to improve surgical efficiency, reduce surgical complications and cost, and facilitating superior clinical outcomes.

Akermin

Venture Round in 2013
Akermin is based in St. Louis, Missouri, and was formed in 2004 to commercialize breakthrough stabilized enzyme technology invented at Saint Louis University. In 2008, Akermin demonstrated its prototype of a fully functioning biofuel cell operating on methanol fuel and using stabilized laccase to replace the metal catalyst in conventional cathodes. Commercial applications in wireless sensors and military uses are their primary focus. Development for the use of stabilized enzymes in the food processing, biofuels, chemical, and pharmaceutical industries is under way.

Tunespeak

Seed Round in 2013
Tunespeak is an online platform that enables users to listen to music, watch videos and photos, and share with friends in order to earn points. It acts as a loyalty platform for musicians. The company was founded in 2011 and headquartered in St Louis, Missouri.

BenchmarkONE

Seed Round in 2012
BenchmarkONE is sales and marketing software for small businesses and marketing agencies. We help agencies and small business owners propel relationships into sales with all-in-one CRM and marketing automation. Cut through the clutter and complexity of bulky tools with a simple, affordable platform made for you.

NeuroLutions

Seed Round in 2012
Neurolutions seeks to develop a revolutionary platform of devices, based on Brain Computer Interface (BCI) technology, which promise to restore function to patients who are disabled as a result of neurological injury.

CardiaLen

Angel Round in 2012
CardiaLen develops and commercializes pain-free cardioversion therapies for atrial fibrillation. The company is developing implantable low-energy (low voltage) pain-free atrial cardioverters to help address the major unmet needs of this condition. It was founded in 2008 and headquartered in Minneapolis, Minnesota.

Kypha

Series A in 2012
Kypha Inc. is an early-stage life sciences company focused on the discovery, development, and commercialization of in-vitro diagnostic biomarker tests targeting inflammation and autoimmune disorders. Based in St. Louis, Missouri, Kypha's flagship product, the COMP ACT System, is designed to enhance the monitoring and treatment of various health conditions, including lupus, stroke, traumatic brain injury, preeclampsia, infection, kidney disease, and transplant rejection. The system offers a rapid and accurate assessment of inflammation levels in the body, facilitating timely clinical interventions by healthcare professionals. Established in 2009, Kypha has successfully raised over $3 million in private capital and leveraged federal grants to advance its diagnostic offerings towards FDA clearance and commercial launch. The company operates with a small core team, supported by a network of scientific advisors and clinical collaborators.

Decide

Seed Round in 2012
Decide is powering the future of performance-based advertising on the open web. Through custom ad formats, flexible integration types, and our homegrown machine-learning platform, the Decision Marketplace, Decide optimizes returns for advertisers and maximizes yield for publishers. Our proprietary attribution and targeting technologies enable industry-leading measurement and eliminate the need for third-party cookies or other intrusive data.

Euclises Pharmaceuticals

Seed Round in 2012
Euclises Pharmaceuticals, Inc is developing novel pain and cancer medications that offer superior safety margins compared to existing drugs. The company is based on new inventions from Dr. John Talley, the most accomplished medicinal chemist in the world. Dr. Talley previously invented Celebrex and seven other approved drugs. New compounds from Euclises will offer both improved efficacy and safety relative to existing therapies. Euclises is located at the BioGenerator Accelerator Labs.

Bonfyre

Angel Round in 2012
Bonfyre is an enterprise communications platform that is changing the way companies build culture and engage their employees. Our technology brings people together and helps organizations build camaraderie, align culture and drive real-time HR business intelligence.

Traxxsson

Seed Round in 2012
Traxxsson is a biotechnology company that develops diagnostics for cancer using protein biomarkers. It uses a proprietary panel of biomarkers to identify at-risk patients who have questionable radiology images. It has three tests: PRO CancSure to identify prostate cancer patients in need of aggressive treatment, BRE CancSure to confirm the presence of breast cancer in women with positive mammograms, and LNG CancSure to confirm the presence of lung cancer in patients with positive low-density CAT scan results. The company was founded in 2009 and is based in St. Louis, Missouri.

Euphrates Vascular

Seed Round in 2011
Pulse Therapeutics is a growing medical technology company headquartered in St. Louis, Mo. The medical developer is advancing the fight against stroke, heart disease, and other conditions with its high-level treatment solutions, which utilize the latest biomedical technology and processes. Pulse’s signature offering, the MED System, was designed to harness magnet-based technology to rapidly dissolve blood clots faster than current modalities. This faster rate of delivery of FDA-approved clot-busting medication could dramatically reduce the number of lives lost each year to stroke, heart disease, and other diseases. This pioneering medical development company was founded by leading physicists Francis “Duke” Creighton and Rogers Ritter. Dr. Creighton, who also serves as Pulse’s chief technical officer, has 20-plus years of expertise in the medical technology industry, specializing in the stroke and cardiovascular sectors. He responsible for 30 patents and is a technology reviewer for the National Cancer Institute, National Science Foundation, and National Institutes of Health. The ground-breaking medical solutions of Pulse Therapeutics continues to attract investors and garner media coverage.

Nawgan

Seed Round in 2011
Nawgan offers a brain-friendly functional beverage developed to provide both long and short-term benefits for the brain. Nawgan contains citicoline (a combination of choline and cytidine); Alpha-GPC (Alpha-glyceryl phosphorylcholine – claimed to increase acetylcholine in the brain); lycopene; caffeine (100mg); and natural vitamin E. Unlike many products in the cognitive function market, claims made by Nawgan were supported by research on the end product rather than extrapolations based on literature about individual ingredients.

Katalyst Surgical

Seed Round in 2011
Katalyst Surgical, LLC provides titanium ophthalmic surgical instruments. It offers cannulas, forceps, hooks/manipulators, lasik products, needle holders, phaco choppers, scissors, speculum, and related products online. Katalyst Surgical, LLC was incorporated in 2010 and is based in Chesterfield, Missouri.

SOMARK Innovations

Venture Round in 2009
Somark is a leader in lab animal identification, providing advanced solutions that protect the integrity of the chain of custody. Our solutions deliver new levels of accuracy and consistency, promoting animal and data welfare. The result is better science for researchers and better business for companies that are developing and supporting research advances.

Akermin

Series A in 2007
Akermin is based in St. Louis, Missouri, and was formed in 2004 to commercialize breakthrough stabilized enzyme technology invented at Saint Louis University. In 2008, Akermin demonstrated its prototype of a fully functioning biofuel cell operating on methanol fuel and using stabilized laccase to replace the metal catalyst in conventional cathodes. Commercial applications in wireless sensors and military uses are their primary focus. Development for the use of stabilized enzymes in the food processing, biofuels, chemical, and pharmaceutical industries is under way.

Appistry

Series A in 2005
Appistry helps clinical labs, research institutions, and hospitals capitalize on genomics data so that they can practice genomically enhanced medicine. Their world-class bioinformatics tools, cloud services, and software streamline the analysis of next-generation sequencing (NGS) data and make genome-scale data actionable in guiding research projects and informing clinical decisions. The Appistry CloudDx products provide cloud-based systems that help clinical research programs conduct patient-centered translational research (CloudDx Translational) and hospitals implement genome-scale tests into routine patient care (CloudDx Clinical). Appistry also empowers researchers by providing world-class bioinformatics tools, cloud services, and software that streamline the analysis of NGS data and provide easy scale for moving research-developed pipelines into production.
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